ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ubiquinone biosynthetic process (GO:0006744)	4.86464667
2	ubiquinone metabolic process (GO:0006743)	4.52187438
3	otic vesicle formation (GO:0030916)	4.29804410
4	ATP synthesis coupled proton transport (GO:0015986)	4.18848059
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.18848059
6	behavioral response to nicotine (GO:0035095)	4.14099969
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.01895984
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.98718072
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.94524281
10	quinone biosynthetic process (GO:1901663)	3.92748816
11	protein complex biogenesis (GO:0070271)	3.85324603
12	protein neddylation (GO:0045116)	3.78460654
13	axonemal dynein complex assembly (GO:0070286)	3.77981894
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.76188383
15	NADH dehydrogenase complex assembly (GO:0010257)	3.76188383
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.76188383
17	ribosomal small subunit assembly (GO:0000028)	3.72499319
18	cytochrome complex assembly (GO:0017004)	3.70295393
19	respiratory chain complex IV assembly (GO:0008535)	3.67816004
20	chaperone-mediated protein transport (GO:0072321)	3.65982594
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.58476776
22	nonmotile primary cilium assembly (GO:0035058)	3.56625542
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.55631129
24	pattern specification involved in kidney development (GO:0061004)	3.51579007
25	organelle disassembly (GO:1903008)	3.51272526
26	nephron epithelium morphogenesis (GO:0072088)	3.49664399
27	nephron tubule morphogenesis (GO:0072078)	3.49664399
28	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.40890287
29	somite development (GO:0061053)	3.39895062
30	regulation of mitotic spindle checkpoint (GO:1903504)	3.32348064
31	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.32348064
32	regulation of cilium movement (GO:0003352)	3.26396889
33	ribonucleoprotein complex disassembly (GO:0032988)	3.25014433
34	DNA deamination (GO:0045006)	3.21892143
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19764561
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.16616249
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.16023322
38	attachment of spindle microtubules to kinetochore (GO:0008608)	3.14769318
39	electron transport chain (GO:0022900)	3.09262732
40	intraciliary transport (GO:0042073)	3.08860273
41	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.07451510
42	respiratory electron transport chain (GO:0022904)	3.03868455
43	cell proliferation in forebrain (GO:0021846)	3.01336860
44	kinetochore assembly (GO:0051382)	2.98124931
45	protein prenylation (GO:0018342)	2.97012850
46	prenylation (GO:0097354)	2.97012850
47	photoreceptor cell development (GO:0042461)	2.92347181
48	RNA destabilization (GO:0050779)	2.85642651
49	mast cell degranulation (GO:0043303)	2.83941049
50	mast cell activation involved in immune response (GO:0002279)	2.83941049
51	S-adenosylmethionine metabolic process (GO:0046500)	2.83900416
52	chromatin remodeling at centromere (GO:0031055)	2.83047058
53	piRNA metabolic process (GO:0034587)	2.82203930
54	hypothalamus development (GO:0021854)	2.79063635
55	recombinational repair (GO:0000725)	2.78365230
56	indolalkylamine metabolic process (GO:0006586)	2.75776607
57	GTP biosynthetic process (GO:0006183)	2.75097231
58	viral transcription (GO:0019083)	2.74411499
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74032833
60	cilium movement (GO:0003341)	2.71782241
61	segment specification (GO:0007379)	2.69921498
62	termination of RNA polymerase III transcription (GO:0006386)	2.69890856
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69890856
64	UTP biosynthetic process (GO:0006228)	2.69313691
65	translational termination (GO:0006415)	2.68526945
66	double-strand break repair via homologous recombination (GO:0000724)	2.68399900
67	limb bud formation (GO:0060174)	2.68183642
68	rRNA catabolic process (GO:0016075)	2.65358904
69	cilium morphogenesis (GO:0060271)	2.65349840
70	UTP metabolic process (GO:0046051)	2.60958984
71	protein K11-linked deubiquitination (GO:0035871)	2.60778311
72	eye photoreceptor cell development (GO:0042462)	2.58011265
73	amino acid salvage (GO:0043102)	2.55470611
74	L-methionine salvage (GO:0071267)	2.55470611
75	L-methionine biosynthetic process (GO:0071265)	2.55470611
76	inner mitochondrial membrane organization (GO:0007007)	2.54558766
77	kinetochore organization (GO:0051383)	2.54428654
78	hindbrain development (GO:0030902)	2.54304974
79	retinal rod cell development (GO:0046548)	2.50871551
80	maturation of SSU-rRNA (GO:0030490)	2.50281957
81	hydrogen ion transmembrane transport (GO:1902600)	2.49886863
82	CENP-A containing nucleosome assembly (GO:0034080)	2.49872825
83	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.48454219
84	translational elongation (GO:0006414)	2.48181043
85	rRNA modification (GO:0000154)	2.48014688
86	artery development (GO:0060840)	2.47386366
87	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46285764
88	DNA damage response, detection of DNA damage (GO:0042769)	2.45745286
89	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.45268021
90	cotranslational protein targeting to membrane (GO:0006613)	2.44110165
91	cornea development in camera-type eye (GO:0061303)	2.43872277
92	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.43824973
93	lens fiber cell development (GO:0070307)	2.43230480
94	aldehyde catabolic process (GO:0046185)	2.42415424
95	proton transport (GO:0015992)	2.42126610
96	ATP biosynthetic process (GO:0006754)	2.40040636
97	hydrogen transport (GO:0006818)	2.39425308
98	proteasome assembly (GO:0043248)	2.39256390
99	microtubule anchoring (GO:0034453)	2.39057061
100	protein targeting to ER (GO:0045047)	2.38803511

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.11035206
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.46195171
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.33778407
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.27357233
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.07918906
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.85339702
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.84505727
8	VDR_22108803_ChIP-Seq_LS180_Human	2.66921975
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43699551
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.10455048
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08879879
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.08678611
13	EWS_26573619_Chip-Seq_HEK293_Human	2.07761448
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03294054
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.97064507
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.90341807
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84846776
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.82186530
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.80628986
20	P300_19829295_ChIP-Seq_ESCs_Human	1.74972560
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.73029946
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.70932102
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66361399
24	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66030366
25	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.64555334
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63799932
27	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.63474286
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58924758
29	FUS_26573619_Chip-Seq_HEK293_Human	1.53367656
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52131426
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52127246
32	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.50510811
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49502435
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.48666964
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48642968
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.48613233
37	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.47529373
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.47085727
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.46507673
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45183677
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36538163
42	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.34328035
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.34251208
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33531924
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.33510721
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.33384097
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32297720
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.31764190
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30705245
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.30705245
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29168323
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28941501
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.28604782
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28336641
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28336641
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27699353
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.27256888
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26477213
59	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.25214228
60	AR_20517297_ChIP-Seq_VCAP_Human	1.25001067
61	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23602068
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17244835
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15514771
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.15167310
65	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15011915
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14522069
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14344451
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13871899
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13667377
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13667377
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12221236
72	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12221236
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11683690
74	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11575313
75	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11523753
76	TTF2_22483619_ChIP-Seq_HELA_Human	1.08773642
77	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07912864
78	NCOR_22424771_ChIP-Seq_293T_Human	1.05533532
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04229775
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.03604202
81	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.02186338
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02040664
83	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00061054
84	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99973734
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99321860
86	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97081273
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96629792
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96369859
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95993469
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95000563
91	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.93029080
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92941117
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90598570
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90544328
95	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.90480799
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90393354
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.90202605
98	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.89578414
99	TCF4_23295773_ChIP-Seq_U87_Human	0.89114009
100	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.89045245

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.29085946
2	MP0008877_abnormal_DNA_methylation	3.25057169
3	MP0000566_synostosis	3.05014670
4	MP0003646_muscle_fatigue	2.87754077
5	MP0002102_abnormal_ear_morphology	2.50702528
6	MP0003136_yellow_coat_color	2.49032534
7	MP0003878_abnormal_ear_physiology	2.47478395
8	MP0005377_hearing/vestibular/ear_phenot	2.47478395
9	MP0002938_white_spotting	2.45184407
10	MP0000569_abnormal_digit_pigmentation	2.38836830
11	MP0001293_anophthalmia	2.31716023
12	MP0005174_abnormal_tail_pigmentation	2.26613042
13	MP0004147_increased_porphyrin_level	2.24000999
14	MP0005075_abnormal_melanosome_morpholog	2.20810880
15	MP0003195_calcinosis	2.13549018
16	MP0002277_abnormal_respiratory_mucosa	2.07493255
17	MP0003011_delayed_dark_adaptation	2.03756154
18	MP0002095_abnormal_skin_pigmentation	1.94620853
19	MP0005551_abnormal_eye_electrophysiolog	1.82604066
20	MP0000372_irregular_coat_pigmentation	1.82287657
21	MP0004885_abnormal_endolymph	1.81423336
22	MP0009780_abnormal_chondrocyte_physiolo	1.80819206
23	MP0005645_abnormal_hypothalamus_physiol	1.77206800
24	MP0008789_abnormal_olfactory_epithelium	1.75175855
25	MP0003787_abnormal_imprinting	1.70265641
26	MP0005646_abnormal_pituitary_gland	1.69871764
27	MP0010030_abnormal_orbit_morphology	1.68183565
28	MP0002282_abnormal_trachea_morphology	1.68077344
29	MP0006072_abnormal_retinal_apoptosis	1.66830545
30	MP0003122_maternal_imprinting	1.62995674
31	MP0005379_endocrine/exocrine_gland_phen	1.59530173
32	MP0005253_abnormal_eye_physiology	1.56677140
33	MP0000631_abnormal_neuroendocrine_gland	1.53625243
34	MP0001348_abnormal_lacrimal_gland	1.46023022
35	MP0002876_abnormal_thyroid_physiology	1.35781083
36	MP0002234_abnormal_pharynx_morphology	1.34423824
37	MP0002138_abnormal_hepatobiliary_system	1.34088549
38	MP0000015_abnormal_ear_pigmentation	1.33463714
39	MP0001188_hyperpigmentation	1.31508227
40	MP0002163_abnormal_gland_morphology	1.30480152
41	MP0005499_abnormal_olfactory_system	1.25493204
42	MP0005394_taste/olfaction_phenotype	1.25493204
43	MP0003724_increased_susceptibility_to	1.24769060
44	MP0004133_heterotaxia	1.22942115
45	MP0003283_abnormal_digestive_organ	1.22911649
46	MP0001529_abnormal_vocalization	1.21819170
47	MP0008872_abnormal_physiological_respon	1.17813530
48	MP0002272_abnormal_nervous_system	1.17469680
49	MP0002653_abnormal_ependyma_morphology	1.17260758
50	MP0000049_abnormal_middle_ear	1.15535339
51	MP0003121_genomic_imprinting	1.12702665
52	MP0009046_muscle_twitch	1.11858744
53	MP0009745_abnormal_behavioral_response	1.10810378
54	MP0004043_abnormal_pH_regulation	1.10360840
55	MP0008875_abnormal_xenobiotic_pharmacok	1.09999773
56	MP0001968_abnormal_touch/_nociception	1.08365452
57	MP0002572_abnormal_emotion/affect_behav	1.06913704
58	MP0001346_abnormal_lacrimal_gland	1.06815588
59	MP0000778_abnormal_nervous_system	1.05701539
60	MP0004142_abnormal_muscle_tone	1.04927270
61	MP0002638_abnormal_pupillary_reflex	1.04899761
62	MP0002233_abnormal_nose_morphology	1.02964834
63	MP0001984_abnormal_olfaction	1.01544639
64	MP0001485_abnormal_pinna_reflex	1.01486562
65	MP0005391_vision/eye_phenotype	1.00011638
66	MP0003937_abnormal_limbs/digits/tail_de	0.98254428
67	MP0002557_abnormal_social/conspecific_i	0.97714469
68	MP0005195_abnormal_posterior_eye	0.97114371
69	MP0009379_abnormal_foot_pigmentation	0.95997415
70	MP0005084_abnormal_gallbladder_morpholo	0.95123153
71	MP0003119_abnormal_digestive_system	0.94800080
72	MP0001324_abnormal_eye_pigmentation	0.91715620
73	MP0001970_abnormal_pain_threshold	0.91497763
74	MP0000026_abnormal_inner_ear	0.90784060
75	MP0003880_abnormal_central_pattern	0.90747567
76	MP0001501_abnormal_sleep_pattern	0.90586384
77	MP0004145_abnormal_muscle_electrophysio	0.89357816
78	MP0002064_seizures	0.88034514
79	MP0003938_abnormal_ear_development	0.87632028
80	MP0002837_dystrophic_cardiac_calcinosis	0.87340556
81	MP0005389_reproductive_system_phenotype	0.86437506
82	MP0001919_abnormal_reproductive_system	0.85507729
83	MP0003718_maternal_effect	0.83742205
84	MP0002752_abnormal_somatic_nervous	0.82073476
85	MP0003755_abnormal_palate_morphology	0.81102316
86	MP0006276_abnormal_autonomic_nervous	0.80904003
87	MP0001440_abnormal_grooming_behavior	0.79923190
88	MP0001929_abnormal_gametogenesis	0.79326082
89	MP0003693_abnormal_embryo_hatching	0.76742307
90	MP0002733_abnormal_thermal_nociception	0.76679423
91	MP0001986_abnormal_taste_sensitivity	0.76238996
92	MP0004742_abnormal_vestibular_system	0.76216468
93	MP0005167_abnormal_blood-brain_barrier	0.75584578
94	MP0003698_abnormal_male_reproductive	0.75031484
95	MP0000647_abnormal_sebaceous_gland	0.74804297
96	MP0002928_abnormal_bile_duct	0.74469835
97	MP0002736_abnormal_nociception_after	0.74286130
98	MP0002210_abnormal_sex_determination	0.73644553
99	MP0001145_abnormal_male_reproductive	0.71547517
100	MP0005365_abnormal_bile_salt	0.70164832

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.11331965
2	Abnormality of midbrain morphology (HP:0002418)	4.11331965
3	True hermaphroditism (HP:0010459)	3.73894115
4	Acute necrotizing encephalopathy (HP:0006965)	3.66686068
5	Pancreatic fibrosis (HP:0100732)	3.55809605
6	Type II lissencephaly (HP:0007260)	3.42817857
7	Progressive macrocephaly (HP:0004481)	3.25155177
8	Mitochondrial inheritance (HP:0001427)	3.22416724
9	Nephronophthisis (HP:0000090)	3.21258627
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14645799
11	Abnormal ciliary motility (HP:0012262)	3.14368887
12	Pancreatic cysts (HP:0001737)	3.10870429
13	Increased CSF lactate (HP:0002490)	3.01037788
14	Acute encephalopathy (HP:0006846)	2.97268049
15	Septo-optic dysplasia (HP:0100842)	2.91126515
16	Medial flaring of the eyebrow (HP:0010747)	2.91114870
17	Increased hepatocellular lipid droplets (HP:0006565)	2.89196449
18	Methylmalonic acidemia (HP:0002912)	2.89145433
19	Abnormality of the labia minora (HP:0012880)	2.88567056
20	Congenital stationary night blindness (HP:0007642)	2.79233231
21	Abnormal respiratory motile cilium physiology (HP:0012261)	2.79026956
22	Hepatocellular necrosis (HP:0001404)	2.78128795
23	Lipid accumulation in hepatocytes (HP:0006561)	2.74772911
24	Sclerocornea (HP:0000647)	2.66918498
25	Agitation (HP:0000713)	2.65974301
26	Abnormality of the renal medulla (HP:0100957)	2.55739345
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53275879
28	Hepatic necrosis (HP:0002605)	2.51839238
29	Anophthalmia (HP:0000528)	2.48893430
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.47032031
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.47032031
32	Gait imbalance (HP:0002141)	2.36576308
33	Decreased central vision (HP:0007663)	2.36309224
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.34275482
35	Cerebral edema (HP:0002181)	2.30416519
36	Anencephaly (HP:0002323)	2.28531888
37	Pendular nystagmus (HP:0012043)	2.27016049
38	Lissencephaly (HP:0001339)	2.26675242
39	Oligodactyly (hands) (HP:0001180)	2.25900106
40	Congenital, generalized hypertrichosis (HP:0004540)	2.25640257
41	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.19812691
42	Limb dystonia (HP:0002451)	2.19676536
43	Optic disc pallor (HP:0000543)	2.18216590
44	Congenital primary aphakia (HP:0007707)	2.16838655
45	Panhypogammaglobulinemia (HP:0003139)	2.15923923
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.15369711
47	Intestinal atresia (HP:0011100)	2.14770488
48	Methylmalonic aciduria (HP:0012120)	2.10336351
49	Rib fusion (HP:0000902)	2.06143475
50	Genital tract atresia (HP:0001827)	2.05237843
51	Abnormal number of erythroid precursors (HP:0012131)	2.04782254
52	Median cleft lip (HP:0000161)	2.04633132
53	Abnormality of cells of the erythroid lineage (HP:0012130)	2.04501902
54	Vaginal atresia (HP:0000148)	2.04420330
55	Maternal diabetes (HP:0009800)	2.03782807
56	Pachygyria (HP:0001302)	2.02932626
57	Increased serum lactate (HP:0002151)	2.00882468
58	Cystic liver disease (HP:0006706)	2.00338748
59	Renal Fanconi syndrome (HP:0001994)	1.99516543
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.99375618
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95063811
62	Nephrogenic diabetes insipidus (HP:0009806)	1.93869761
63	Absent septum pellucidum (HP:0001331)	1.93563450
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93382556
65	Gastrointestinal atresia (HP:0002589)	1.91841709
66	Optic nerve hypoplasia (HP:0000609)	1.91154366
67	Volvulus (HP:0002580)	1.87284540
68	Postaxial foot polydactyly (HP:0001830)	1.85978738
69	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.85022158
70	Holoprosencephaly (HP:0001360)	1.83917646
71	Retinal dysplasia (HP:0007973)	1.83752749
72	Lethargy (HP:0001254)	1.83164679
73	Postaxial hand polydactyly (HP:0001162)	1.82907533
74	Preaxial hand polydactyly (HP:0001177)	1.81859138
75	11 pairs of ribs (HP:0000878)	1.81136609
76	Chronic sinusitis (HP:0011109)	1.80158638
77	3-Methylglutaconic aciduria (HP:0003535)	1.79480688
78	Attenuation of retinal blood vessels (HP:0007843)	1.79472151
79	Reticulocytopenia (HP:0001896)	1.79073874
80	Esophageal atresia (HP:0002032)	1.77941754
81	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77798613
82	Homocystinuria (HP:0002156)	1.77313124
83	Abnormality of homocysteine metabolism (HP:0010919)	1.77313124
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76773394
85	Increased intramyocellular lipid droplets (HP:0012240)	1.76508943
86	Macrocytic anemia (HP:0001972)	1.76307591
87	Abolished electroretinogram (ERG) (HP:0000550)	1.75987941
88	Dandy-Walker malformation (HP:0001305)	1.75552221
89	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74748040
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.74589891
91	Absent/shortened dynein arms (HP:0200106)	1.74589891
92	Respiratory failure (HP:0002878)	1.74388372
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74313507
94	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.73766709
95	Hyperglycinemia (HP:0002154)	1.73501924
96	Abnormality of renal resorption (HP:0011038)	1.73106307
97	Abnormality of the renal cortex (HP:0011035)	1.73025058
98	Abnormality of the middle phalanges of the toes (HP:0010183)	1.72069199
99	Furrowed tongue (HP:0000221)	1.71888042
100	Thyroid-stimulating hormone excess (HP:0002925)	1.71036742

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.43122652
2	BMPR1B	3.15799378
3	CDK8	2.76345238
4	STK16	2.73367615
5	FRK	2.61723079
6	WNK3	2.38630136
7	CASK	2.37917741
8	TRIM28	2.35230955
9	BUB1	2.27747447
10	ADRBK2	2.16742709
11	GRK1	2.12285987
12	TLK1	2.06794456
13	FGFR2	1.95427029
14	NUAK1	1.90941618
15	MAP4K2	1.88254983
16	WNK4	1.84977348
17	PINK1	1.84577910
18	PLK3	1.79308939
19	BRSK2	1.76321265
20	VRK1	1.70918721
21	VRK2	1.59670643
22	PNCK	1.58971176
23	ZAK	1.57746753
24	TAF1	1.53704141
25	MAP2K7	1.47786694
26	TGFBR1	1.45936517
27	WEE1	1.45726414
28	DYRK2	1.45576200
29	KIT	1.44634043
30	BCKDK	1.43808702
31	CCNB1	1.36258204
32	INSRR	1.29212927
33	PLK4	1.28997256
34	PLK2	1.28263168
35	NME1	1.23867895
36	MAPK13	1.19053960
37	MAP3K4	1.14450207
38	MARK3	1.14188015
39	CAMK1D	1.09770471
40	TNIK	1.09358001
41	NEK1	1.02027658
42	TXK	1.01112625
43	CSNK1G2	0.96258827
44	CAMK1G	0.95240207
45	EPHA4	0.94816444
46	PRKCH	0.87254474
47	EIF2AK2	0.85662297
48	CSNK1G3	0.84852895
49	CDK19	0.84374784
50	NTRK2	0.83016567
51	TIE1	0.77720798
52	TSSK6	0.77645145
53	PLK1	0.77454947
54	MKNK2	0.77369638
55	CSNK1G1	0.76850122
56	STK3	0.71839730
57	BCR	0.70118015
58	PRKCG	0.68658325
59	PRKCI	0.68477980
60	AURKA	0.67652523
61	CHEK2	0.67528837
62	WNK1	0.67147542
63	PHKG2	0.66435791
64	PHKG1	0.66435791
65	MAPK15	0.65962410
66	FGFR1	0.64342396
67	MAP2K6	0.62892890
68	BRSK1	0.62626383
69	MATK	0.61013125
70	SRPK1	0.60488164
71	CSNK1A1L	0.59307291
72	MINK1	0.57389867
73	MARK1	0.57106882
74	AURKB	0.57009634
75	PKN1	0.56179115
76	CDC7	0.54134348
77	MAP2K4	0.53846925
78	CSNK2A2	0.49208284
79	SYK	0.45726652
80	IRAK4	0.45335472
81	LATS1	0.43745794
82	OXSR1	0.43185828
83	MAP4K1	0.43009637
84	MAP3K12	0.42718074
85	CAMKK2	0.41858815
86	ADRBK1	0.41388171
87	PDK2	0.40374432
88	TEC	0.39368023
89	CSNK2A1	0.38293827
90	PIK3CG	0.38113172
91	PRKACA	0.37640808
92	PRKACB	0.37253533
93	PRKCZ	0.37208116
94	PRKCE	0.36562970
95	CAMK1	0.34926597
96	FLT3	0.34706876
97	CSNK1E	0.34622867
98	ACVR1B	0.30768840
99	CSNK1A1	0.29375758
100	MST4	0.29025211

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.01662522
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.13525605
3	Ribosome_Homo sapiens_hsa03010	3.02086294
4	Protein export_Homo sapiens_hsa03060	2.68361620
5	Parkinsons disease_Homo sapiens_hsa05012	2.66274637
6	Asthma_Homo sapiens_hsa05310	2.22262577
7	Homologous recombination_Homo sapiens_hsa03440	2.18117005
8	RNA polymerase_Homo sapiens_hsa03020	2.17957141
9	Proteasome_Homo sapiens_hsa03050	2.12288947
10	Phototransduction_Homo sapiens_hsa04744	1.97268705
11	Huntingtons disease_Homo sapiens_hsa05016	1.89286330
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82751752
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.82483763
14	Basal transcription factors_Homo sapiens_hsa03022	1.80448337
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.73163019
16	Butanoate metabolism_Homo sapiens_hsa00650	1.73039448
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.72851699
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.71863276
19	RNA degradation_Homo sapiens_hsa03018	1.68998419
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.61206051
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58815605
22	Alzheimers disease_Homo sapiens_hsa05010	1.55668265
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.41943753
24	Propanoate metabolism_Homo sapiens_hsa00640	1.41513770
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39996551
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35729690
27	Spliceosome_Homo sapiens_hsa03040	1.33793277
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32734240
29	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.31268096
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31072245
31	Mismatch repair_Homo sapiens_hsa03430	1.30661989
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30652198
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25770857
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23786329
35	Sulfur relay system_Homo sapiens_hsa04122	1.21022047
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.20300388
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19789500
38	Nicotine addiction_Homo sapiens_hsa05033	1.19778648
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17372427
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07154409
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.04518112
42	Sulfur metabolism_Homo sapiens_hsa00920	1.04344190
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.02048082
44	DNA replication_Homo sapiens_hsa03030	1.01154943
45	Fatty acid degradation_Homo sapiens_hsa00071	1.00445058
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.00067396
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.99574045
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96159117
49	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.93958581
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91403872
51	One carbon pool by folate_Homo sapiens_hsa00670	0.90367618
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.89783732
53	Taste transduction_Homo sapiens_hsa04742	0.88134705
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86888272
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.85701406
56	Peroxisome_Homo sapiens_hsa04146	0.84039505
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83355432
58	RNA transport_Homo sapiens_hsa03013	0.83318261
59	Allograft rejection_Homo sapiens_hsa05330	0.83134387
60	Olfactory transduction_Homo sapiens_hsa04740	0.81863374
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.80840109
62	Purine metabolism_Homo sapiens_hsa00230	0.80706269
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80196266
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79654987
65	Insulin secretion_Homo sapiens_hsa04911	0.77913359
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75416935
67	Morphine addiction_Homo sapiens_hsa05032	0.74445362
68	Caffeine metabolism_Homo sapiens_hsa00232	0.73073078
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72844014
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72606166
71	Retinol metabolism_Homo sapiens_hsa00830	0.71198684
72	Metabolic pathways_Homo sapiens_hsa01100	0.68701434
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66685317
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66161079
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.65397794
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.65387356
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65274076
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.64152313
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.63486951
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.61235437
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.58942680
82	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56183751
83	Folate biosynthesis_Homo sapiens_hsa00790	0.53882545
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50497688
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49001345
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.46943382
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.46730127
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46137949
89	GABAergic synapse_Homo sapiens_hsa04727	0.45633916
90	Serotonergic synapse_Homo sapiens_hsa04726	0.45452472
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44061280
92	Base excision repair_Homo sapiens_hsa03410	0.43835064
93	Histidine metabolism_Homo sapiens_hsa00340	0.43452808
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.41071035
95	Fatty acid elongation_Homo sapiens_hsa00062	0.40383005
96	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39835849
97	Mineral absorption_Homo sapiens_hsa04978	0.39264986
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35864145
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33272084
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32304920

HMGB1P45

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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