ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein deneddylation (GO:0000338)	9.29892859
2	phosphorylated carbohydrate dephosphorylation (GO:0046838)	8.92291961
3	inositol phosphate dephosphorylation (GO:0046855)	8.92291961
4	platelet dense granule organization (GO:0060155)	8.22079447
5	inositol phosphate catabolic process (GO:0071545)	8.12859814
6	response to misfolded protein (GO:0051788)	7.07688593
7	vitamin transmembrane transport (GO:0035461)	6.73367686
8	regulation of vesicle fusion (GO:0031338)	6.56881623
9	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	6.45032816
10	inositol metabolic process (GO:0006020)	6.35809915
11	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	6.27454630
12	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	6.27454630
13	early endosome to late endosome transport (GO:0045022)	6.02975661
14	proline transport (GO:0015824)	5.84910856
15	polyol catabolic process (GO:0046174)	5.58825014
16	L-ascorbic acid metabolic process (GO:0019852)	5.48131226
17	rhodopsin mediated signaling pathway (GO:0016056)	5.47049516
18	artery development (GO:0060840)	5.41158756
19	protein targeting to Golgi (GO:0000042)	5.35292925
20	ADP metabolic process (GO:0046031)	5.20340354
21	regulation of sequestering of triglyceride (GO:0010889)	5.20297460
22	establishment of protein localization to Golgi (GO:0072600)	5.13714039
23	negative regulation of exocytosis (GO:0045920)	5.05937947
24	endosome organization (GO:0007032)	5.04711131
25	transepithelial transport (GO:0070633)	4.94816970
26	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.77879294
27	histone H2A ubiquitination (GO:0033522)	4.69894101
28	microtubule nucleation (GO:0007020)	4.60298444
29	phosphatidylinositol phosphorylation (GO:0046854)	4.58200283
30	photoreceptor cell maintenance (GO:0045494)	4.56827160
31	retinol metabolic process (GO:0042572)	4.54734860
32	DNA replication-dependent nucleosome assembly (GO:0006335)	4.54628924
33	DNA replication-dependent nucleosome organization (GO:0034723)	4.54628924
34	positive regulation of mitochondrial membrane permeability (GO:0035794)	4.47017561
35	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	4.42876261
36	protein localization to Golgi apparatus (GO:0034067)	4.35951454
37	regulation of Rac protein signal transduction (GO:0035020)	4.31611164
38	righting reflex (GO:0060013)	4.25780285
39	auditory behavior (GO:0031223)	4.25177260
40	receptor recycling (GO:0001881)	4.21357010
41	regulation of prostaglandin secretion (GO:0032306)	3.98310902
42	alanine transport (GO:0032328)	3.94661196
43	anterograde synaptic vesicle transport (GO:0048490)	3.94645519
44	retinal cone cell development (GO:0046549)	3.89753423
45	lipid phosphorylation (GO:0046834)	3.78808073
46	reflex (GO:0060004)	3.68920777
47	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.55488897
48	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.49555412
49	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.49555412
50	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.47147088
51	thyroid gland development (GO:0030878)	3.40863369
52	protein polyglutamylation (GO:0018095)	3.35393967
53	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	3.32963600
54	behavioral response to nicotine (GO:0035095)	3.32704678
55	protein K11-linked ubiquitination (GO:0070979)	3.27161939
56	polyol biosynthetic process (GO:0046173)	3.24663188
57	behavioral response to ethanol (GO:0048149)	3.21887787
58	piRNA metabolic process (GO:0034587)	3.21799073
59	negative regulation of cAMP-mediated signaling (GO:0043951)	3.21741035
60	positive regulation of cell cycle G1/S phase transition (GO:1902808)	3.19921529
61	folic acid-containing compound biosynthetic process (GO:0009396)	3.19834100
62	postreplication repair (GO:0006301)	3.17597617
63	axoneme assembly (GO:0035082)	3.16995075
64	phototransduction (GO:0007602)	3.12979614
65	positive regulation of cAMP-mediated signaling (GO:0043950)	3.11209987
66	secretory granule organization (GO:0033363)	3.10779085
67	purine ribonucleoside diphosphate metabolic process (GO:0009179)	3.04079020
68	purine nucleoside diphosphate metabolic process (GO:0009135)	3.04079020
69	detection of light stimulus (GO:0009583)	3.01032458
70	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.00636487
71	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.00636487
72	histone H3-K9 methylation (GO:0051567)	2.99605879
73	microtubule depolymerization (GO:0007019)	2.98665780
74	transcytosis (GO:0045056)	2.96941509
75	positive regulation of lipid storage (GO:0010884)	2.96846000
76	rRNA catabolic process (GO:0016075)	2.96750695
77	negative regulation of protein autophosphorylation (GO:0031953)	2.96233740
78	purine nucleotide salvage (GO:0032261)	2.94695871
79	energy homeostasis (GO:0097009)	2.91869721
80	cAMP catabolic process (GO:0006198)	2.91248500
81	anterograde axon cargo transport (GO:0008089)	2.91050120
82	regulation of mitotic spindle checkpoint (GO:1903504)	2.89221579
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.89221579
84	melanosome organization (GO:0032438)	2.83148767
85	mechanosensory behavior (GO:0007638)	2.79855838
86	tetrahydrofolate metabolic process (GO:0046653)	2.78445390
87	UTP metabolic process (GO:0046051)	2.77002425
88	primary alcohol metabolic process (GO:0034308)	2.75548806
89	protein-cofactor linkage (GO:0018065)	2.71311887
90	negative regulation of mast cell activation (GO:0033004)	2.70314796
91	positive regulation of tolerance induction (GO:0002645)	2.69458752
92	epithelial cilium movement (GO:0003351)	2.67749796
93	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.65716118
94	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.65716118
95	regulation of MHC class I biosynthetic process (GO:0045343)	2.65075520
96	cholesterol catabolic process (GO:0006707)	2.63270557
97	sterol catabolic process (GO:0016127)	2.63270557
98	pigment granule organization (GO:0048753)	2.62341568
99	protein-chromophore linkage (GO:0018298)	10.7250623
100	cullin deneddylation (GO:0010388)	10.1869486

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.73318496
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.14532420
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.24788655
4	IGF1R_20145208_ChIP-Seq_DFB_Human	4.24652446
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.30078321
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57347987
7	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.44393378
8	FUS_26573619_Chip-Seq_HEK293_Human	2.37700732
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.21332074
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.08596258
11	NANOG_19829295_ChIP-Seq_ESCs_Human	2.04327733
12	SOX2_19829295_ChIP-Seq_ESCs_Human	2.04327733
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.94934024
14	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93032952
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92760675
16	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.91045636
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90805817
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90695329
19	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.79151397
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.77458244
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72603338
22	P300_19829295_ChIP-Seq_ESCs_Human	1.71797771
23	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.68157162
24	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.68157162
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.63027586
26	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.62762713
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61407717
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60912586
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.59914264
30	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.57484237
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54666708
32	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54142159
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53010069
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48161135
35	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.47714725
36	STAT3_23295773_ChIP-Seq_U87_Human	1.46800924
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.45576572
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43601500
39	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40720571
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.39104174
41	AR_20517297_ChIP-Seq_VCAP_Human	1.38764182
42	TCF4_23295773_ChIP-Seq_U87_Human	1.38475931
43	AR_25329375_ChIP-Seq_VCAP_Human	1.37364945
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36988628
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34855976
46	HTT_18923047_ChIP-ChIP_STHdh_Human	1.31221216
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30054706
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.29156625
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27670878
50	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.27450547
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27105392
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.23429221
53	OCT4_20526341_ChIP-Seq_ESCs_Human	1.21263427
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20948842
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20948842
56	ERG_20517297_ChIP-Seq_VCAP_Human	1.20923802
57	JUN_21703547_ChIP-Seq_K562_Human	1.20893787
58	EWS_26573619_Chip-Seq_HEK293_Human	1.20775985
59	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.20584132
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.20370852
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.19886168
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18181556
63	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.17405171
64	ERA_21632823_ChIP-Seq_H3396_Human	1.17290266
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14905919
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14735059
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13508005
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12425967
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11042263
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.10835719
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09322424
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08556613
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08356432
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07989301
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07439017
76	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.07364669
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07351942
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05988550
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04484311
80	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.04285620
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03208091
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02064348
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01469399
84	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.00295869
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00243772
86	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96865333
87	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96678376
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95513231
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95215170
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.95167980
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94066205
92	AR_19668381_ChIP-Seq_PC3_Human	0.93463591
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93456902
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93337171
95	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92888261
96	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.91774907
97	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.91245386
98	SPI1_20517297_ChIP-Seq_HL60_Human	0.91221265
99	GF1_26923725_Chip-Seq_HPCs_Mouse	0.91137693
100	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.90225191

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	9.44289819
2	MP0005083_abnormal_biliary_tract	8.71615163
3	MP0002638_abnormal_pupillary_reflex	7.00179261
4	MP0005085_abnormal_gallbladder_physiolo	5.04899216
5	MP0005084_abnormal_gallbladder_morpholo	4.98800092
6	MP0005365_abnormal_bile_salt	4.07243325
7	MP0002928_abnormal_bile_duct	3.27810974
8	MP0006072_abnormal_retinal_apoptosis	3.10212878
9	MP0005253_abnormal_eye_physiology	2.86643653
10	MP0001764_abnormal_homeostasis	2.80978748
11	MP0005379_endocrine/exocrine_gland_phen	2.33869182
12	MP0001502_abnormal_circadian_rhythm	2.27033485
13	MP0003195_calcinosis	2.04396248
14	MP0005551_abnormal_eye_electrophysiolog	1.96597959
15	MP0002138_abnormal_hepatobiliary_system	1.71524733
16	MP0003183_abnormal_peptide_metabolism	1.68623792
17	MP0001905_abnormal_dopamine_level	1.61037638
18	MP0002160_abnormal_reproductive_system	1.52994237
19	MP0006082_CNS_inflammation	1.46198039
20	MP0003122_maternal_imprinting	1.44487564
21	MP0003943_abnormal_hepatobiliary_system	1.43989061
22	MP0004043_abnormal_pH_regulation	1.41732730
23	MP0010386_abnormal_urinary_bladder	1.37464950
24	MP0003718_maternal_effect	1.19181030
25	MP0002909_abnormal_adrenal_gland	1.17135631
26	MP0000427_abnormal_hair_cycle	1.13591409
27	MP0003693_abnormal_embryo_hatching	1.09833949
28	MP0008877_abnormal_DNA_methylation	1.03408150
29	MP0005391_vision/eye_phenotype	1.00861704
30	MP0004859_abnormal_synaptic_plasticity	0.97384792
31	MP0001529_abnormal_vocalization	0.93239968
32	MP0003252_abnormal_bile_duct	0.92507706
33	MP0008775_abnormal_heart_ventricle	0.90597321
34	MP0003136_yellow_coat_color	0.87109791
35	MP0004019_abnormal_vitamin_homeostasis	0.86153873
36	MP0003121_genomic_imprinting	0.85792967
37	MP0009046_muscle_twitch	0.85361857
38	MP0002234_abnormal_pharynx_morphology	0.84188792
39	MP0005595_abnormal_vascular_smooth	0.82859254
40	MP0005220_abnormal_exocrine_pancreas	0.82661339
41	MP0003646_muscle_fatigue	0.81781475
42	MP0001440_abnormal_grooming_behavior	0.80827440
43	MP0008058_abnormal_DNA_repair	0.78398453
44	MP0000230_abnormal_systemic_arterial	0.78301118
45	MP0005389_reproductive_system_phenotype	0.76636349
46	MP0002572_abnormal_emotion/affect_behav	0.75342681
47	MP0010094_abnormal_chromosome_stability	0.73746517
48	MP0008961_abnormal_basal_metabolism	0.71997007
49	MP0003868_abnormal_feces_composition	0.69067995
50	MP0005195_abnormal_posterior_eye	0.68385072
51	MP0008875_abnormal_xenobiotic_pharmacok	0.67974953
52	MP0002752_abnormal_somatic_nervous	0.67099081
53	MP0002102_abnormal_ear_morphology	0.66260021
54	MP0005376_homeostasis/metabolism_phenot	0.60841383
55	MP0002064_seizures	0.59347267
56	MP0001986_abnormal_taste_sensitivity	0.59143947
57	MP0005670_abnormal_white_adipose	0.59091655
58	MP0002163_abnormal_gland_morphology	0.59081879
59	MP0009745_abnormal_behavioral_response	0.58673412
60	MP0003656_abnormal_erythrocyte_physiolo	0.58091901
61	MP0004215_abnormal_myocardial_fiber	0.57544387
62	MP0005167_abnormal_blood-brain_barrier	0.55220716
63	MP0003806_abnormal_nucleotide_metabolis	0.55098103
64	MP0008872_abnormal_physiological_respon	0.54927419
65	MP0002184_abnormal_innervation	0.54271386
66	MP0000538_abnormal_urinary_bladder	0.53668598
67	MP0005410_abnormal_fertilization	0.53483413
68	MP0002735_abnormal_chemical_nociception	0.53354069
69	MP0001545_abnormal_hematopoietic_system	0.52641277
70	MP0005397_hematopoietic_system_phenotyp	0.52641277
71	MP0009384_cardiac_valve_regurgitation	0.51386732
72	MP0000639_abnormal_adrenal_gland	0.50451170
73	MP0002272_abnormal_nervous_system	0.49802467
74	MP0004142_abnormal_muscle_tone	0.49775970
75	MP0001853_heart_inflammation	0.49422964
76	MP0001968_abnormal_touch/_nociception	0.48599337
77	MP0001501_abnormal_sleep_pattern	0.48510686
78	MP0005310_abnormal_salivary_gland	0.47459223
79	MP0002837_dystrophic_cardiac_calcinosis	0.47116281
80	MP0000579_abnormal_nail_morphology	0.45454339
81	MP0003950_abnormal_plasma_membrane	0.42995017
82	MP0005360_urolithiasis	0.42836471
83	MP0002090_abnormal_vision	0.41177349
84	MP0009780_abnormal_chondrocyte_physiolo	0.41170749
85	MP0002733_abnormal_thermal_nociception	0.40123731
86	MP0004957_abnormal_blastocyst_morpholog	0.40118711
87	MP0008874_decreased_physiological_sensi	0.39413382
88	MP0004145_abnormal_muscle_electrophysio	0.39003902
89	MP0005647_abnormal_sex_gland	0.38284773
90	MP0001486_abnormal_startle_reflex	0.37691647
91	MP0000372_irregular_coat_pigmentation	0.37643730
92	MP0005395_other_phenotype	0.35576459
93	MP0005646_abnormal_pituitary_gland	0.35469950
94	MP0009672_abnormal_birth_weight	0.35130209
95	MP0001919_abnormal_reproductive_system	0.34667568
96	MP0008932_abnormal_embryonic_tissue	0.32780683
97	MP0002229_neurodegeneration	0.31290522
98	MP0002118_abnormal_lipid_homeostasis	0.28234922
99	MP0003953_abnormal_hormone_level	0.27948082
100	MP0005452_abnormal_adipose_tissue	0.27470820

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Azoospermia (HP:0000027)	6.78551469
2	Abnormal spermatogenesis (HP:0008669)	5.74611303
3	Broad face (HP:0000283)	5.61731392
4	Abnormal hair whorl (HP:0010721)	5.37112168
5	Amyotrophic lateral sclerosis (HP:0007354)	5.01673240
6	Tetraplegia (HP:0002445)	4.96807168
7	Atrophy/Degeneration involving motor neurons (HP:0007373)	4.71857695
8	Upper motor neuron abnormality (HP:0002127)	4.65405358
9	Hand muscle atrophy (HP:0009130)	4.38610572
10	Spastic tetraparesis (HP:0001285)	4.14311570
11	Abnormality of the lower motor neuron (HP:0002366)	4.08474641
12	Progressive inability to walk (HP:0002505)	3.67907979
13	Degeneration of anterior horn cells (HP:0002398)	3.57230774
14	Abnormality of the anterior horn cell (HP:0006802)	3.57230774
15	Abnormality of the corticospinal tract (HP:0002492)	3.48674232
16	Volvulus (HP:0002580)	3.41508081
17	Abnormality of the renal cortex (HP:0011035)	3.35563668
18	Congenital stationary night blindness (HP:0007642)	3.33715698
19	Upper limb amyotrophy (HP:0009129)	3.13659142
20	Distal upper limb amyotrophy (HP:0007149)	3.13659142
21	Pancreatic cysts (HP:0001737)	3.13270065
22	Diminished movement (HP:0002374)	3.11882535
23	Generalized aminoaciduria (HP:0002909)	3.04888197
24	Renal cortical cysts (HP:0000803)	2.93574460
25	Abnormality of midbrain morphology (HP:0002418)	2.88172863
26	Molar tooth sign on MRI (HP:0002419)	2.88172863
27	Tubular atrophy (HP:0000092)	2.83236596
28	Hypokinesia (HP:0002375)	2.81723969
29	Chronic hepatic failure (HP:0100626)	2.78199915
30	Inability to walk (HP:0002540)	2.69422051
31	Achilles tendon contracture (HP:0001771)	2.61866412
32	Opisthotonus (HP:0002179)	2.60630606
33	Hepatic necrosis (HP:0002605)	2.60240812
34	Pseudobulbar signs (HP:0002200)	2.58886836
35	Nephronophthisis (HP:0000090)	2.51700141
36	Type II diabetes mellitus (HP:0005978)	2.50311574
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.47376311
38	Abnormality of the motor neurons (HP:0002450)	2.41468084
39	Abnormal neuron morphology (HP:0012757)	2.41468084
40	Myokymia (HP:0002411)	2.40919980
41	Photophobia (HP:0000613)	2.35329279
42	Increased density of long bones (HP:0006392)	2.35158828
43	Prominent supraorbital ridges (HP:0000336)	2.33921313
44	Spastic tetraplegia (HP:0002510)	2.33894274
45	Akinesia (HP:0002304)	2.33653552
46	Abnormality of the Achilles tendon (HP:0005109)	2.32415905
47	Ependymoma (HP:0002888)	2.29156839
48	Congenital, generalized hypertrichosis (HP:0004540)	2.27042366
49	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.24773177
50	Short 4th metacarpal (HP:0010044)	2.24773177
51	Broad hallux (HP:0010055)	2.23997446
52	Delayed gross motor development (HP:0002194)	2.23812918
53	Abnormality of the basal ganglia (HP:0002134)	2.23229545
54	Abnormal auditory evoked potentials (HP:0006958)	2.21771284
55	Stomach cancer (HP:0012126)	2.21134985
56	Short tibia (HP:0005736)	2.16047323
57	Anhidrosis (HP:0000970)	2.13683656
58	Pancreatic fibrosis (HP:0100732)	2.11635165
59	Stomatitis (HP:0010280)	2.11461578
60	True hermaphroditism (HP:0010459)	2.08830905
61	Attenuation of retinal blood vessels (HP:0007843)	2.08201817
62	Tongue fasciculations (HP:0001308)	2.07291833
63	Urethral obstruction (HP:0000796)	2.06379461
64	Hepatocellular necrosis (HP:0001404)	2.02011028
65	Adactyly (HP:0009776)	2.01497688
66	Morphological abnormality of the pyramidal tract (HP:0002062)	1.99582481
67	Abolished electroretinogram (ERG) (HP:0000550)	1.99102640
68	Type II lissencephaly (HP:0007260)	1.98433142
69	Abnormality of the renal medulla (HP:0100957)	1.97933137
70	Agnosia (HP:0010524)	1.96029126
71	Downturned corners of mouth (HP:0002714)	1.94192213
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93029005
73	Cholecystitis (HP:0001082)	1.91978996
74	Abnormal gallbladder physiology (HP:0012438)	1.91978996
75	CNS demyelination (HP:0007305)	1.91768413
76	Poor speech (HP:0002465)	1.91027835
77	Recurrent gram-negative bacterial infections (HP:0005420)	1.89907750
78	Methylmalonic acidemia (HP:0002912)	1.88686676
79	Progressive sensorineural hearing impairment (HP:0000408)	1.85556253
80	Wide intermamillary distance (HP:0006610)	1.83582338
81	Abnormality of the 4th metacarpal (HP:0010012)	1.82611760
82	Childhood onset (HP:0011463)	1.80570858
83	Methylmalonic aciduria (HP:0012120)	1.80363256
84	Hypoplastic pelvis (HP:0008839)	1.79107754
85	Dry hair (HP:0011359)	1.78337160
86	Hypoplastic ischia (HP:0003175)	1.77831144
87	Increased circulating renin level (HP:0000848)	1.74227041
88	Muscle fibrillation (HP:0010546)	1.71948317
89	Concave nail (HP:0001598)	1.71479688
90	Hyperglycinemia (HP:0002154)	1.71294149
91	Supernumerary spleens (HP:0009799)	1.70215607
92	Hypoglycemic coma (HP:0001325)	1.70181830
93	Abnormality of the musculature of the hand (HP:0001421)	1.69700506
94	Palpebral edema (HP:0100540)	1.69307868
95	Abnormality of ocular smooth pursuit (HP:0000617)	1.68550932
96	Polydipsia (HP:0001959)	1.67580888
97	Abnormal drinking behavior (HP:0030082)	1.67580888
98	Cutaneous finger syndactyly (HP:0010554)	1.66233718
99	Medial flaring of the eyebrow (HP:0010747)	1.65531446
100	Broad toe (HP:0001837)	1.64481891

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	4.70848371
2	FRK	2.96676445
3	PIK3CG	2.92164464
4	MAP3K9	2.84945189
5	EIF2AK1	2.60591425
6	NEK6	2.24228489
7	ARAF	2.05404485
8	EIF2AK3	2.00132212
9	NME1	11.0500237
10	NTRK2	1.93735690
11	ERBB3	1.81725138
12	NUAK1	1.76639979
13	LIMK1	1.76017062
14	PINK1	1.75626899
15	TIE1	1.54927433
16	PIM2	1.54878091
17	TAOK3	1.49984081
18	GRK1	1.43394488
19	TESK1	1.36040038
20	TLK1	1.26753664
21	MAPK13	1.25765337
22	OXSR1	1.18425411
23	CAMKK2	1.16564123
24	NEK9	1.12324027
25	BMPR1B	1.07185572
26	AURKA	1.06684174
27	ADRBK2	1.05877806
28	PTK2B	0.93572379
29	BRD4	0.93099653
30	STK39	0.92622575
31	NEK1	0.90642624
32	PRKCQ	0.88896100
33	WNK4	0.88513453
34	WNK3	0.86325694
35	MAPKAPK5	0.80535936
36	MET	0.80335329
37	ZAK	0.74451246
38	MAP2K6	0.72388527
39	PIK3CA	0.70246268
40	TEC	0.68930408
41	CAMKK1	0.67840133
42	NTRK3	0.67452333
43	PHKG1	0.65318040
44	PHKG2	0.65318040
45	PRKCG	0.64550969
46	PRKCI	0.62475656
47	MARK1	0.59285285
48	PRKAA2	0.57352197
49	EIF2AK2	0.52567961
50	MAP4K2	0.51593926
51	CSNK1G2	0.48487274
52	TSSK6	0.45980886
53	TGFBR1	0.45733655
54	PRKCH	0.45232420
55	BCKDK	0.44957228
56	PRKACA	0.44948740
57	DAPK2	0.43552538
58	MAPK7	0.43496584
59	BRAF	0.42612479
60	RAF1	0.39317072
61	FGR	0.39130558
62	CDK1	0.38904580
63	PRKCE	0.37923751
64	CAMK1D	0.37735845
65	INSRR	0.37601448
66	CSNK1G3	0.37470440
67	ACVR1B	0.36116178
68	DYRK2	0.35969114
69	MAPKAPK3	0.35491365
70	LATS1	0.35299001
71	MAPK12	0.35064725
72	IKBKB	0.34444950
73	PLK4	0.33381355
74	CSNK1G1	0.32935812
75	CAMK1	0.31983808
76	OBSCN	0.31166094
77	PRKCB	0.30108722
78	PDPK1	0.29793522
79	CAMK2A	0.29584296
80	AKT2	0.27608413
81	ROCK1	0.26732760
82	CSNK1A1L	0.25869668
83	PRKACB	0.25071024
84	MAP3K4	0.23897236
85	PDK1	0.23452220
86	STK38L	0.23145749
87	TNK2	0.22639401
88	RPS6KA5	0.21862332
89	ADRBK1	0.20767734
90	VRK1	0.20601176
91	PAK6	0.19979773
92	PIM1	0.18834185
93	SRPK1	0.18769155
94	CAMK4	0.18088892
95	CDK5	0.18086330
96	PLK1	0.17983695
97	FLT3	0.17917308
98	PRKG1	0.16713541
99	RPS6KB1	0.16402240
100	PRKCA	0.16131375

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.95363129
2	One carbon pool by folate_Homo sapiens_hsa00670	3.79556079
3	Phototransduction_Homo sapiens_hsa04744	2.94606931
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.84622504
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.79362263
6	Retinol metabolism_Homo sapiens_hsa00830	2.74017845
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.64337275
8	Inositol phosphate metabolism_Homo sapiens_hsa00562	2.61655998
9	Regulation of autophagy_Homo sapiens_hsa04140	2.55244412
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.22733347
11	Basal transcription factors_Homo sapiens_hsa03022	2.16237109
12	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.84226550
13	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.77957488
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.77649174
15	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.64814434
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63725208
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.63156445
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.58612367
19	Olfactory transduction_Homo sapiens_hsa04740	1.57441880
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54960590
21	ABC transporters_Homo sapiens_hsa02010	1.54485977
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.52053268
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.49234949
24	RNA degradation_Homo sapiens_hsa03018	1.46521867
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.41493769
26	Parkinsons disease_Homo sapiens_hsa05012	1.38578705
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.37429560
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.36642986
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.36553979
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.31539291
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.31201992
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31158035
33	Morphine addiction_Homo sapiens_hsa05032	1.30803198
34	Mismatch repair_Homo sapiens_hsa03430	1.24939243
35	Caffeine metabolism_Homo sapiens_hsa00232	1.23838444
36	Homologous recombination_Homo sapiens_hsa03440	1.20938949
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.17500922
38	Histidine metabolism_Homo sapiens_hsa00340	1.15012519
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10544814
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10447507
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10365013
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06458357
43	Bile secretion_Homo sapiens_hsa04976	1.06236949
44	Huntingtons disease_Homo sapiens_hsa05016	1.05175673
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.02253006
46	Nicotine addiction_Homo sapiens_hsa05033	1.00593281
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.97884989
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.92855455
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89735964
50	Glutathione metabolism_Homo sapiens_hsa00480	0.86679731
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.85677479
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85114241
53	Salivary secretion_Homo sapiens_hsa04970	0.85083726
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.84269503
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.81119337
56	Butanoate metabolism_Homo sapiens_hsa00650	0.80644995
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78677651
58	Metabolic pathways_Homo sapiens_hsa01100	0.78523252
59	Taste transduction_Homo sapiens_hsa04742	0.78062296
60	Purine metabolism_Homo sapiens_hsa00230	0.77982913
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75402344
62	Alzheimers disease_Homo sapiens_hsa05010	0.73725972
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73061490
64	Circadian rhythm_Homo sapiens_hsa04710	0.71483187
65	Insulin secretion_Homo sapiens_hsa04911	0.70951765
66	Lysine degradation_Homo sapiens_hsa00310	0.68346654
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66969766
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.64331601
69	Fatty acid elongation_Homo sapiens_hsa00062	0.63801947
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.59894219
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59147807
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56978023
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55977978
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.55286491
75	Gastric acid secretion_Homo sapiens_hsa04971	0.53893996
76	Renin-angiotensin system_Homo sapiens_hsa04614	0.53229041
77	Propanoate metabolism_Homo sapiens_hsa00640	0.50208934
78	Peroxisome_Homo sapiens_hsa04146	0.50005944
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49570451
80	Oocyte meiosis_Homo sapiens_hsa04114	0.49206975
81	Base excision repair_Homo sapiens_hsa03410	0.48174232
82	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46618763
83	GABAergic synapse_Homo sapiens_hsa04727	0.44983694
84	Graft-versus-host disease_Homo sapiens_hsa05332	0.44424985
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44135786
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.43748211
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43020157
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42624246
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.39969409
90	Proteasome_Homo sapiens_hsa03050	0.39874932
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38459012
92	Fatty acid degradation_Homo sapiens_hsa00071	0.36523499
93	Complement and coagulation cascades_Homo sapiens_hsa04610	0.34240233
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33396466
95	DNA replication_Homo sapiens_hsa03030	0.32987916
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32978953
97	RNA transport_Homo sapiens_hsa03013	0.32713533
98	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.30922448
99	Pancreatic secretion_Homo sapiens_hsa04972	0.29103338
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28842406

HMGB1P46

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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