ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of glucokinase activity (GO:0033131)	6.95646906
2	regulation of hexokinase activity (GO:1903299)	6.95646906
3	ether lipid metabolic process (GO:0046485)	6.18812217
4	cellular ketone body metabolic process (GO:0046950)	5.21259859
5	signal peptide processing (GO:0006465)	5.10762325
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.77058542
7	glucosamine-containing compound catabolic process (GO:1901072)	4.77014699
8	oxidative demethylation (GO:0070989)	4.75047722
9	ketone body metabolic process (GO:1902224)	4.60701317
10	phosphate ion transmembrane transport (GO:0035435)	4.46843828
11	behavioral response to nicotine (GO:0035095)	4.37061704
12	lactate metabolic process (GO:0006089)	4.29181026
13	glycerol ether metabolic process (GO:0006662)	4.21774050
14	negative regulation of bone resorption (GO:0045779)	4.06707832
15	urinary tract smooth muscle contraction (GO:0014848)	4.06087455
16	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.95896306
17	ether metabolic process (GO:0018904)	3.93780009
18	protein prenylation (GO:0018342)	3.89607476
19	prenylation (GO:0097354)	3.89607476
20	phosphate ion transport (GO:0006817)	3.81151863
21	DNA deamination (GO:0045006)	3.76465453
22	ubiquinone biosynthetic process (GO:0006744)	3.70227199
23	endocrine pancreas development (GO:0031018)	3.69180102
24	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.69162700
25	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.68887892
26	L-ascorbic acid metabolic process (GO:0019852)	3.68840793
27	positive regulation of respiratory burst (GO:0060267)	3.62996872
28	protein complex biogenesis (GO:0070271)	3.54534695
29	positive regulation of glycolytic process (GO:0045821)	3.46423284
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42924584
31	negative regulation of protein oligomerization (GO:0032460)	3.38278208
32	righting reflex (GO:0060013)	3.38217963
33	respiratory chain complex IV assembly (GO:0008535)	3.27618981
34	somite rostral/caudal axis specification (GO:0032525)	3.25620070
35	xenobiotic catabolic process (GO:0042178)	3.24890362
36	ubiquinone metabolic process (GO:0006743)	3.22356545
37	DNA double-strand break processing (GO:0000729)	3.21294891
38	platelet dense granule organization (GO:0060155)	3.19344402
39	regulation of cilium movement (GO:0003352)	3.18039961
40	negative regulation of bone remodeling (GO:0046851)	3.17221487
41	detection of calcium ion (GO:0005513)	3.13522725
42	atrial cardiac muscle cell action potential (GO:0086014)	3.13254754
43	kidney morphogenesis (GO:0060993)	3.10628982
44	glucosamine-containing compound metabolic process (GO:1901071)	3.08500420
45	response to pheromone (GO:0019236)	3.05182768
46	negative regulation of acute inflammatory response (GO:0002674)	3.05120645
47	GTP biosynthetic process (GO:0006183)	2.99542112
48	startle response (GO:0001964)	2.98642128
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96659982
50	NADH dehydrogenase complex assembly (GO:0010257)	2.96659982
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96659982
52	glycerophospholipid catabolic process (GO:0046475)	2.96239500
53	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.94437342
54	cytochrome complex assembly (GO:0017004)	2.94296678
55	quinone biosynthetic process (GO:1901663)	2.91987303
56	inositol phosphate catabolic process (GO:0071545)	2.91117479
57	fucose catabolic process (GO:0019317)	2.88798870
58	L-fucose metabolic process (GO:0042354)	2.88798870
59	L-fucose catabolic process (GO:0042355)	2.88798870
60	nucleoside diphosphate catabolic process (GO:0009134)	2.88116637
61	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.85883165
62	regulation of cardioblast proliferation (GO:0003264)	2.85883165
63	axonemal dynein complex assembly (GO:0070286)	2.78153183
64	peptide hormone processing (GO:0016486)	2.78121277
65	positive regulation of peptide hormone secretion (GO:0090277)	2.74997490
66	epithelial cilium movement (GO:0003351)	2.74583269
67	regulation of glycolytic process (GO:0006110)	2.74215828
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.73949808
69	chemosensory behavior (GO:0007635)	2.72602318
70	protein K11-linked deubiquitination (GO:0035871)	2.71312724
71	cornea development in camera-type eye (GO:0061303)	2.70666056
72	DNA demethylation (GO:0080111)	2.66615899
73	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.66059032
74	maturation of 5.8S rRNA (GO:0000460)	2.64406264
75	nonmotile primary cilium assembly (GO:0035058)	2.63302863
76	positive regulation of peptide secretion (GO:0002793)	2.62942438
77	positive regulation of neurotransmitter transport (GO:0051590)	2.61043295
78	zinc ion transport (GO:0006829)	2.59653503
79	fatty acid homeostasis (GO:0055089)	2.59285569
80	neuromuscular process controlling posture (GO:0050884)	2.56872791
81	protein polyglutamylation (GO:0018095)	2.56560330
82	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.55760626
83	keratan sulfate catabolic process (GO:0042340)	2.55438856
84	positive regulation of insulin secretion (GO:0032024)	2.54742692
85	COPII vesicle coating (GO:0048208)	2.54677240
86	cilium movement (GO:0003341)	2.53535702
87	positive regulation of glycogen biosynthetic process (GO:0045725)	2.53423458
88	positive regulation of meiosis (GO:0045836)	2.52949964
89	urate metabolic process (GO:0046415)	2.52169134
90	UTP metabolic process (GO:0046051)	2.50898904
91	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.50790214
92	UTP biosynthetic process (GO:0006228)	2.47634086
93	negative regulation of tissue remodeling (GO:0034104)	2.46740349
94	insulin secretion (GO:0030073)	2.45406082
95	presynaptic membrane assembly (GO:0097105)	2.45179223
96	nitric oxide mediated signal transduction (GO:0007263)	2.44415542
97	negative regulation of potassium ion transport (GO:0043267)	2.44146713
98	positive regulation of TOR signaling (GO:0032008)	2.43768451
99	heart field specification (GO:0003128)	2.43441916
100	secondary heart field specification (GO:0003139)	2.43441916

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44092827
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.37167895
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.31948028
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.11963696
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.82178537
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.54504802
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53018352
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41774000
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32141016
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.31254725
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.28667695
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28463582
13	FUS_26573619_Chip-Seq_HEK293_Human	2.26154379
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.15138116
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10290466
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09896624
17	VDR_22108803_ChIP-Seq_LS180_Human	2.02245203
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98420508
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98281168
20	P300_19829295_ChIP-Seq_ESCs_Human	1.91905723
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.88491052
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.88004743
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.87588134
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.82079567
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.79409437
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71794953
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.68846451
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59766689
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58584180
30	AR_25329375_ChIP-Seq_VCAP_Human	1.56715667
31	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.53711175
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53415583
33	STAT3_23295773_ChIP-Seq_U87_Human	1.52950604
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51479378
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50551845
36	GATA1_22025678_ChIP-Seq_K562_Human	1.50396977
37	EWS_26573619_Chip-Seq_HEK293_Human	1.47188795
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45107763
39	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.44767649
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43972621
41	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.40016923
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38269383
43	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36838082
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.36457721
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35232027
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.29535884
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28022096
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27336359
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26859210
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26859210
51	TCF4_23295773_ChIP-Seq_U87_Human	1.26474678
52	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.25384841
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25058165
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24265005
55	AR_20517297_ChIP-Seq_VCAP_Human	1.23996269
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.22904417
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21954777
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21937558
59	IGF1R_20145208_ChIP-Seq_DFB_Human	1.21351937
60	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19926215
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19827386
62	NCOR_22424771_ChIP-Seq_293T_Human	1.19220635
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18730228
64	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.17303947
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15639552
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.15212576
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14700308
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14558195
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14558195
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.14522932
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14319961
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.13987223
73	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11542093
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09917881
75	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09785999
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09470443
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09323060
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09323060
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08507425
80	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.07714250
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06033830
82	CBP_20019798_ChIP-Seq_JUKART_Human	1.06033830
83	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04888242
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04811386
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04018230
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03964954
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03953283
88	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03671777
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03492093
90	TAF15_26573619_Chip-Seq_HEK293_Human	1.03414936
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02796565
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02571939
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.01232123
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00553250
95	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00490179
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99959001
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99529220
98	ELK1_19687146_ChIP-ChIP_HELA_Human	0.99512476
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.98561529
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98490896

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.59053416
2	MP0006072_abnormal_retinal_apoptosis	3.74430200
3	MP0003787_abnormal_imprinting	3.32450173
4	MP0008877_abnormal_DNA_methylation	3.21167139
5	MP0001984_abnormal_olfaction	3.17390382
6	MP0002638_abnormal_pupillary_reflex	2.56070917
7	MP0005551_abnormal_eye_electrophysiolog	2.52446780
8	MP0000427_abnormal_hair_cycle	2.40928818
9	MP0004133_heterotaxia	2.26505015
10	MP0003122_maternal_imprinting	2.17601563
11	MP0005220_abnormal_exocrine_pancreas	2.12815483
12	MP0001944_abnormal_pancreas_morphology	2.03090931
13	MP0010386_abnormal_urinary_bladder	2.00751210
14	MP0002909_abnormal_adrenal_gland	1.97688296
15	MP0002928_abnormal_bile_duct	1.92130635
16	MP0003868_abnormal_feces_composition	1.91320726
17	MP0003123_paternal_imprinting	1.88827082
18	MP0002938_white_spotting	1.80632112
19	MP0002693_abnormal_pancreas_physiology	1.75604143
20	MP0004142_abnormal_muscle_tone	1.75124020
21	MP0009046_muscle_twitch	1.72371949
22	MP0001968_abnormal_touch/_nociception	1.66651111
23	MP0000613_abnormal_salivary_gland	1.65895795
24	MP0005448_abnormal_energy_balance	1.58560657
25	MP0005645_abnormal_hypothalamus_physiol	1.57848935
26	MP0002102_abnormal_ear_morphology	1.54135595
27	MP0003880_abnormal_central_pattern	1.52110001
28	MP0008872_abnormal_physiological_respon	1.50378900
29	MP0009745_abnormal_behavioral_response	1.49361967
30	MP0004885_abnormal_endolymph	1.48731281
31	MP0005253_abnormal_eye_physiology	1.47920074
32	MP0003121_genomic_imprinting	1.46979121
33	MP0002095_abnormal_skin_pigmentation	1.45408527
34	MP0000015_abnormal_ear_pigmentation	1.43607153
35	MP0000566_synostosis	1.43156866
36	MP0005379_endocrine/exocrine_gland_phen	1.43018576
37	MP0005360_urolithiasis	1.41916141
38	MP0002272_abnormal_nervous_system	1.41136584
39	MP0001919_abnormal_reproductive_system	1.40904388
40	MP0005389_reproductive_system_phenotype	1.40804974
41	MP0002734_abnormal_mechanical_nocicepti	1.40189186
42	MP0003283_abnormal_digestive_organ	1.37941102
43	MP0002078_abnormal_glucose_homeostasis	1.36556271
44	MP0001501_abnormal_sleep_pattern	1.35970274
45	MP0002876_abnormal_thyroid_physiology	1.34986238
46	MP0000569_abnormal_digit_pigmentation	1.31012839
47	MP0002090_abnormal_vision	1.30393919
48	MP0005646_abnormal_pituitary_gland	1.28036595
49	MP0002229_neurodegeneration	1.26352608
50	MP0003633_abnormal_nervous_system	1.25509099
51	MP0002735_abnormal_chemical_nociception	1.24966320
52	MP0008995_early_reproductive_senescence	1.24426947
53	MP0000631_abnormal_neuroendocrine_gland	1.23795014
54	MP0008057_abnormal_DNA_replication	1.23722009
55	MP0004270_analgesia	1.23495757
56	MP0002837_dystrophic_cardiac_calcinosis	1.23027307
57	MP0010329_abnormal_lipoprotein_level	1.22907877
58	MP0005084_abnormal_gallbladder_morpholo	1.20457672
59	MP0003045_fibrosis	1.19485436
60	MP0004215_abnormal_myocardial_fiber	1.18850893
61	MP0005410_abnormal_fertilization	1.18783348
62	MP0003866_abnormal_defecation	1.18573501
63	MP0001727_abnormal_embryo_implantation	1.18256596
64	MP0002160_abnormal_reproductive_system	1.18199972
65	MP0006036_abnormal_mitochondrial_physio	1.14873852
66	MP0010234_abnormal_vibrissa_follicle	1.12870010
67	MP0001986_abnormal_taste_sensitivity	1.11617003
68	MP0002064_seizures	1.08110293
69	MP0003953_abnormal_hormone_level	1.07356031
70	MP0005174_abnormal_tail_pigmentation	1.06820893
71	MP0002572_abnormal_emotion/affect_behav	1.04470824
72	MP0004043_abnormal_pH_regulation	1.04230791
73	MP0001970_abnormal_pain_threshold	1.03600160
74	MP0003137_abnormal_impulse_conducting	1.02708153
75	MP0008875_abnormal_xenobiotic_pharmacok	1.00440665
76	MP0005195_abnormal_posterior_eye	1.00025496
77	MP0002557_abnormal_social/conspecific_i	0.99642846
78	MP0003786_premature_aging	0.98717355
79	MP0003635_abnormal_synaptic_transmissio	0.98689376
80	MP0005535_abnormal_body_temperature	0.95336568
81	MP0000647_abnormal_sebaceous_gland	0.95334910
82	MP0005266_abnormal_metabolism	0.95084412
83	MP0001756_abnormal_urination	0.94764556
84	MP0006054_spinal_hemorrhage	0.94630376
85	MP0001929_abnormal_gametogenesis	0.94218629
86	MP0005386_behavior/neurological_phenoty	0.92484223
87	MP0004924_abnormal_behavior	0.92484223
88	MP0005452_abnormal_adipose_tissue	0.91924519
89	MP0002254_reproductive_system_inflammat	0.90146994
90	MP0008961_abnormal_basal_metabolism	0.87869408
91	MP0003252_abnormal_bile_duct	0.87604823
92	MP0002277_abnormal_respiratory_mucosa	0.86721146
93	MP0003959_abnormal_lean_body	0.85259727
94	MP0001764_abnormal_homeostasis	0.82519284
95	MP0001324_abnormal_eye_pigmentation	0.81561523
96	MP0008775_abnormal_heart_ventricle	0.80065937
97	MP0002184_abnormal_innervation	0.78223316
98	MP0002069_abnormal_eating/drinking_beha	0.77324017
99	MP0005332_abnormal_amino_acid	0.77319006
100	MP0000516_abnormal_urinary_system	0.76413797

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic seizures (HP:0002173)	4.26910097
2	Ketoacidosis (HP:0001993)	4.11951105
3	Abnormality of small intestinal villus morphology (HP:0011472)	4.08704453
4	Villous atrophy (HP:0011473)	4.08704453
5	Hyperinsulinemic hypoglycemia (HP:0000825)	3.75502148
6	Hypothermia (HP:0002045)	3.73516804
7	Pancreatic fibrosis (HP:0100732)	3.69427663
8	Hypoglycemic coma (HP:0001325)	3.63626850
9	Large for gestational age (HP:0001520)	3.52649945
10	True hermaphroditism (HP:0010459)	3.51480198
11	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.44853014
12	Progressive macrocephaly (HP:0004481)	3.44112068
13	Acute necrotizing encephalopathy (HP:0006965)	3.41523066
14	Long nose (HP:0003189)	3.34955220
15	Symptomatic seizures (HP:0011145)	3.28918239
16	Hypomagnesemia (HP:0002917)	3.28412058
17	Rhinitis (HP:0012384)	3.21515424
18	Abnormal drinking behavior (HP:0030082)	3.20152227
19	Polydipsia (HP:0001959)	3.20152227
20	Decreased muscle mass (HP:0003199)	3.18179731
21	Pancreatic cysts (HP:0001737)	3.17191667
22	Abnormality of midbrain morphology (HP:0002418)	3.11929919
23	Molar tooth sign on MRI (HP:0002419)	3.11929919
24	Chronic hepatic failure (HP:0100626)	2.98282428
25	Increased circulating renin level (HP:0000848)	2.96178205
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.95199987
27	Abnormality of methionine metabolism (HP:0010901)	2.95192305
28	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.90072878
29	Hypobetalipoproteinemia (HP:0003563)	2.81510813
30	Choroideremia (HP:0001139)	2.80516209
31	Drooling (HP:0002307)	2.78798255
32	Acute encephalopathy (HP:0006846)	2.78384133
33	Calf muscle hypertrophy (HP:0008981)	2.77246827
34	Abnormality of the pancreatic islet cells (HP:0006476)	2.71810238
35	Abnormality of endocrine pancreas physiology (HP:0012093)	2.71810238
36	Medial flaring of the eyebrow (HP:0010747)	2.69842680
37	Stomatitis (HP:0010280)	2.61225511
38	Occipital encephalocele (HP:0002085)	2.60489989
39	Abnormality of magnesium homeostasis (HP:0004921)	2.58607215
40	Excessive salivation (HP:0003781)	2.57818398
41	Hepatic necrosis (HP:0002605)	2.57150627
42	Mitochondrial inheritance (HP:0001427)	2.56708442
43	Nephronophthisis (HP:0000090)	2.56428515
44	Prominent metopic ridge (HP:0005487)	2.55805988
45	Furrowed tongue (HP:0000221)	2.54260722
46	Cerebral edema (HP:0002181)	2.52190960
47	Neoplasm of the adrenal cortex (HP:0100641)	2.48821917
48	Hyperglycemia (HP:0003074)	2.46511350
49	Sensory axonal neuropathy (HP:0003390)	2.42887706
50	Muscle hypertrophy of the lower extremities (HP:0008968)	2.39403539
51	Renal cortical cysts (HP:0000803)	2.38421221
52	Tetany (HP:0001281)	2.37832048
53	Constricted visual fields (HP:0001133)	2.37498645
54	Pancreatic islet-cell hyperplasia (HP:0004510)	2.35069733
55	Increased density of long bones (HP:0006392)	2.33975381
56	Cystic liver disease (HP:0006706)	2.29769734
57	Increased CSF lactate (HP:0002490)	2.29641715
58	Congenital primary aphakia (HP:0007707)	2.27121471
59	Gait imbalance (HP:0002141)	2.26461529
60	Hepatocellular necrosis (HP:0001404)	2.22803483
61	Ketosis (HP:0001946)	2.22459224
62	Congenital stationary night blindness (HP:0007642)	2.17111539
63	Male pseudohermaphroditism (HP:0000037)	2.17049585
64	Tongue fasciculations (HP:0001308)	2.15983086
65	Abnormality of the renal cortex (HP:0011035)	2.14308017
66	Poor coordination (HP:0002370)	2.13372644
67	Diminished movement (HP:0002374)	2.12962546
68	Narrow forehead (HP:0000341)	2.11135362
69	Hypokinesia (HP:0002375)	2.10188421
70	Abnormality of the metopic suture (HP:0005556)	2.07657056
71	Malnutrition (HP:0004395)	2.06801535
72	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.05765350
73	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.05765350
74	Poor head control (HP:0002421)	2.03396416
75	Polyuria (HP:0000103)	2.00586696
76	Abnormal biliary tract physiology (HP:0012439)	1.98687648
77	Bile duct proliferation (HP:0001408)	1.98687648
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98167397
79	Enlarged penis (HP:0000040)	1.98091205
80	Prolonged QT interval (HP:0001657)	1.96897864
81	Hyperventilation (HP:0002883)	1.96178411
82	Glomerulonephritis (HP:0000099)	1.96155897
83	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.93362575
84	Congenital malformation of the right heart (HP:0011723)	1.93232764
85	Double outlet right ventricle (HP:0001719)	1.93232764
86	Abnormal hair laboratory examination (HP:0003328)	1.91386725
87	Sclerocornea (HP:0000647)	1.91169919
88	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.90541758
89	Abnormal albumin level (HP:0012116)	1.90398972
90	Hypoalbuminemia (HP:0003073)	1.90398972
91	Colon cancer (HP:0003003)	1.87650405
92	Hyperglycinuria (HP:0003108)	1.87464823
93	Abnormality of vitamin B metabolism (HP:0004340)	1.86253929
94	Congenital, generalized hypertrichosis (HP:0004540)	1.85814364
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84094738
96	Hypoplastic ischia (HP:0003175)	1.83340935
97	Nephrogenic diabetes insipidus (HP:0009806)	1.82926899
98	Abnormality of the renal medulla (HP:0100957)	1.81956141
99	Late onset (HP:0003584)	1.81717904
100	Severe muscular hypotonia (HP:0006829)	1.79294392

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	6.38256376
2	FRK	5.65310298
3	CASK	4.05219374
4	NUAK1	3.34958145
5	CAMK1G	3.22904000
6	INSRR	3.04392395
7	EIF2AK1	3.01172608
8	VRK2	2.44573147
9	CAMKK2	2.13096094
10	FGFR2	2.01731088
11	TNIK	1.93182328
12	STK39	1.80931114
13	TAF1	1.76023973
14	WNK3	1.72908758
15	WNK4	1.57841898
16	DAPK2	1.56323896
17	FGFR3	1.48619129
18	MKNK2	1.44957941
19	EPHA3	1.40766745
20	GRK1	1.39585434
21	VRK1	1.39532648
22	NTRK3	1.38395673
23	MST4	1.37838812
24	OXSR1	1.36533270
25	STK16	1.31765413
26	PINK1	1.30244137
27	IRAK4	1.29369262
28	CAMK1	1.18974159
29	TSSK6	1.18020048
30	TLK1	1.16805360
31	STK38L	1.08408314
32	IRAK1	1.03765181
33	ADRBK2	1.01088323
34	DAPK1	0.97334705
35	PRKCG	0.95217174
36	CAMK1D	0.93760865
37	NLK	0.89631598
38	FER	0.89485370
39	MAP3K12	0.88874833
40	PRKAA2	0.86449103
41	TRIM28	0.81324688
42	DYRK2	0.81064594
43	DMPK	0.81055846
44	LIMK1	0.80298034
45	EIF2AK3	0.80200353
46	IKBKB	0.79446853
47	STK3	0.77777429
48	KDR	0.77775709
49	SCYL2	0.73924451
50	MAP4K2	0.72770752
51	CDK3	0.72025676
52	PRKAA1	0.69689431
53	MAP3K4	0.68945931
54	CHUK	0.68123528
55	PTK2B	0.66345560
56	PLK3	0.65273071
57	RPS6KB2	0.64545050
58	STK11	0.64033872
59	PAK3	0.62582322
60	MAPK15	0.61945403
61	PHKG2	0.60665956
62	PHKG1	0.60665956
63	CAMK2D	0.58618144
64	HIPK2	0.49174112
65	PRKCI	0.48539669
66	CSNK1G1	0.47992956
67	GRK5	0.47634017
68	BMPR1B	0.46931843
69	ERBB3	0.46759647
70	ACVR1B	0.46048259
71	TAOK3	0.45735258
72	RPS6KA4	0.45092477
73	PRKCE	0.44875567
74	CSNK1G3	0.42402999
75	MKNK1	0.41701349
76	ITK	0.41343619
77	CSNK1G2	0.41243831
78	MAP2K7	0.41206840
79	MAPKAPK5	0.41017003
80	RPS6KA5	0.40738020
81	ILK	0.40660643
82	MYLK	0.40104437
83	FGR	0.39686809
84	RAF1	0.38419247
85	DAPK3	0.38316188
86	PRKACA	0.38249401
87	TEC	0.33845087
88	CAMKK1	0.32855242
89	MAP3K2	0.31818969
90	PRKCQ	0.31743836
91	PRKACB	0.30954118
92	CAMK2A	0.30411172
93	PRKD3	0.27300447
94	ROCK2	0.26109739
95	NME1	0.25937420
96	ROCK1	0.25118464
97	PRKACG	0.23140783
98	OBSCN	0.22539345
99	ZAK	0.22368083
100	MARK1	0.21341624

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	6.09506841
2	Protein export_Homo sapiens_hsa03060	5.28126101
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.65833493
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.01404603
5	Butanoate metabolism_Homo sapiens_hsa00650	2.96324987
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.47761233
7	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.18891058
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15817745
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.13973024
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.10983084
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.10257846
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.06589797
13	Insulin secretion_Homo sapiens_hsa04911	1.85337512
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.79304290
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70552442
16	One carbon pool by folate_Homo sapiens_hsa00670	1.61809486
17	Regulation of autophagy_Homo sapiens_hsa04140	1.59968512
18	Type II diabetes mellitus_Homo sapiens_hsa04930	1.58091127
19	Parkinsons disease_Homo sapiens_hsa05012	1.51527506
20	Phototransduction_Homo sapiens_hsa04744	1.46106443
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.33806785
22	Propanoate metabolism_Homo sapiens_hsa00640	1.30895428
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29382272
24	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.29045113
25	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.28384386
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.20998698
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.19199743
28	Peroxisome_Homo sapiens_hsa04146	1.15165354
29	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.10127644
30	Type I diabetes mellitus_Homo sapiens_hsa04940	1.09316768
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08612772
32	Fatty acid elongation_Homo sapiens_hsa00062	1.07911696
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.04531229
34	Folate biosynthesis_Homo sapiens_hsa00790	1.00540851
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.99992410
36	RNA polymerase_Homo sapiens_hsa03020	0.99965300
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95902604
38	Selenocompound metabolism_Homo sapiens_hsa00450	0.94356897
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.91249416
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90150256
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86789685
42	Huntingtons disease_Homo sapiens_hsa05016	0.86766116
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85660775
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83187484
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80743543
46	Alzheimers disease_Homo sapiens_hsa05010	0.79567916
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.79283615
48	mTOR signaling pathway_Homo sapiens_hsa04150	0.77909717
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76248625
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75642275
51	ABC transporters_Homo sapiens_hsa02010	0.74986326
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74710283
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.74263995
54	Nicotine addiction_Homo sapiens_hsa05033	0.71537827
55	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.71403923
56	Caffeine metabolism_Homo sapiens_hsa00232	0.71346168
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.71061322
58	RNA degradation_Homo sapiens_hsa03018	0.70981487
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.70385597
60	Metabolic pathways_Homo sapiens_hsa01100	0.69428199
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69074010
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68621341
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68470184
64	Melanoma_Homo sapiens_hsa05218	0.64159399
65	Circadian rhythm_Homo sapiens_hsa04710	0.63376464
66	Purine metabolism_Homo sapiens_hsa00230	0.62907332
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61510330
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61354957
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58021948
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.58017477
71	Amphetamine addiction_Homo sapiens_hsa05031	0.57406192
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54676954
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.52921721
74	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.52249112
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46747579
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46475452
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45479914
78	Insulin resistance_Homo sapiens_hsa04931	0.42840921
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41864349
80	Mineral absorption_Homo sapiens_hsa04978	0.41661364
81	Circadian entrainment_Homo sapiens_hsa04713	0.41560809
82	Glutathione metabolism_Homo sapiens_hsa00480	0.40743261
83	Renin secretion_Homo sapiens_hsa04924	0.40174910
84	Lysosome_Homo sapiens_hsa04142	0.39967277
85	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38666349
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37852291
87	Legionellosis_Homo sapiens_hsa05134	0.32809396
88	Homologous recombination_Homo sapiens_hsa03440	0.32120645
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31985630
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31947987
91	Taste transduction_Homo sapiens_hsa04742	0.31472425
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29406708
93	Basal transcription factors_Homo sapiens_hsa03022	0.27344308
94	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.26209731
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25268576
96	Olfactory transduction_Homo sapiens_hsa04740	0.24147449
97	Cocaine addiction_Homo sapiens_hsa05030	0.23197259
98	Fatty acid degradation_Homo sapiens_hsa00071	0.22959561
99	Proteasome_Homo sapiens_hsa03050	0.21583237
100	Serotonergic synapse_Homo sapiens_hsa04726	0.20229807

HMGB1P47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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