ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.54364078
2	DNA deamination (GO:0045006)	6.15322453
3	cytidine metabolic process (GO:0046087)	5.24432601
4	cytidine catabolic process (GO:0006216)	5.24432601
5	cytidine deamination (GO:0009972)	5.24432601
6	behavioral response to nicotine (GO:0035095)	4.77986262
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.58649109
8	DNA strand renaturation (GO:0000733)	4.54399704
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.23731363
10	maturation of SSU-rRNA (GO:0030490)	4.20435121
11	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.17594248
12	regulation of response to tumor cell (GO:0002834)	4.12165764
13	positive regulation of response to tumor cell (GO:0002836)	4.12165764
14	positive regulation of immune response to tumor cell (GO:0002839)	4.12165764
15	regulation of immune response to tumor cell (GO:0002837)	4.12165764
16	epithelial cilium movement (GO:0003351)	4.08227347
17	L-fucose catabolic process (GO:0042355)	3.99800887
18	fucose catabolic process (GO:0019317)	3.99800887
19	L-fucose metabolic process (GO:0042354)	3.99800887
20	chaperone-mediated protein transport (GO:0072321)	3.82132978
21	valine metabolic process (GO:0006573)	3.74642848
22	maturation of 5.8S rRNA (GO:0000460)	3.73523448
23	regulation of oxidative stress-induced neuron death (GO:1903203)	3.72414335
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.65432989
25	NADH dehydrogenase complex assembly (GO:0010257)	3.65432989
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.65432989
27	activated T cell proliferation (GO:0050798)	3.64507436
28	replication fork processing (GO:0031297)	3.61644510
29	ATP synthesis coupled proton transport (GO:0015986)	3.60892741
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.60892741
31	pyrimidine nucleotide catabolic process (GO:0006244)	3.56372408
32	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.55675522
33	axonemal dynein complex assembly (GO:0070286)	3.50129060
34	base-excision repair, AP site formation (GO:0006285)	3.49431432
35	regulation of mitochondrial translation (GO:0070129)	3.47912105
36	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.46996364
37	ribosomal small subunit assembly (GO:0000028)	3.44406077
38	protein complex biogenesis (GO:0070271)	3.41241500
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.39918078
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.36853811
41	protein neddylation (GO:0045116)	3.25047202
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.19506118
43	viral transcription (GO:0019083)	3.15713832
44	response to xenobiotic stimulus (GO:0009410)	3.12564196
45	translational termination (GO:0006415)	3.11406454
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.08540347
47	termination of RNA polymerase III transcription (GO:0006386)	3.08540347
48	rRNA catabolic process (GO:0016075)	3.07313367
49	regulation of DNA endoreduplication (GO:0032875)	3.02062539
50	ribosomal small subunit biogenesis (GO:0042274)	3.01152230
51	positive regulation of defense response to virus by host (GO:0002230)	2.99460554
52	negative regulation of telomere maintenance (GO:0032205)	2.95738054
53	positive regulation of receptor biosynthetic process (GO:0010870)	2.95376916
54	protein import into peroxisome matrix (GO:0016558)	2.91809516
55	pseudouridine synthesis (GO:0001522)	2.89241625
56	cilium movement (GO:0003341)	2.88713559
57	intracellular protein transmembrane import (GO:0044743)	2.88520961
58	aspartate family amino acid catabolic process (GO:0009068)	2.88389312
59	proteasome assembly (GO:0043248)	2.85158195
60	centriole replication (GO:0007099)	2.84320207
61	dopamine transport (GO:0015872)	2.82376435
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.81734117
63	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.81206201
64	resolution of meiotic recombination intermediates (GO:0000712)	2.79553490
65	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.78914364
66	positive regulation of guanylate cyclase activity (GO:0031284)	2.77743669
67	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.77018640
68	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.76772944
69	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.76772944
70	regulation of translation, ncRNA-mediated (GO:0045974)	2.76772944
71	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.75667833
72	GMP metabolic process (GO:0046037)	2.73833043
73	platelet dense granule organization (GO:0060155)	2.73238113
74	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.72969493
75	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.72949843
76	DNA damage response, detection of DNA damage (GO:0042769)	2.72872425
77	parturition (GO:0007567)	2.71216480
78	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.71092930
79	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.68527368
80	negative regulation of thymocyte apoptotic process (GO:0070244)	2.68461232
81	DNA double-strand break processing (GO:0000729)	2.66832480
82	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.65087766
83	pyrimidine-containing compound catabolic process (GO:0072529)	2.64040631
84	protein targeting to ER (GO:0045047)	2.63347134
85	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62719275
86	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.61994821
87	rhodopsin mediated signaling pathway (GO:0016056)	2.61779709
88	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.60336738
89	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.60336738
90	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.59955863
91	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.59955863
92	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.59955863
93	cotranslational protein targeting to membrane (GO:0006613)	2.59936371
94	regulation of centriole replication (GO:0046599)	2.58238962
95	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.57484112
96	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.57179558
97	negative regulation of ligase activity (GO:0051352)	2.57179558
98	translational elongation (GO:0006414)	2.57076161
99	spliceosomal complex assembly (GO:0000245)	2.56419375
100	autophagic vacuole fusion (GO:0000046)	2.56412063

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.73330418
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.13027059
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.91183039
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.73443802
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.51045307
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89427243
7	VDR_22108803_ChIP-Seq_LS180_Human	2.73730822
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.62957030
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50789636
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.49735622
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34013873
12	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.33538542
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.29021727
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.26013302
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.15650220
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.06656814
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.04854192
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.00846797
19	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.99655407
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.98156453
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97998255
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.94829282
23	EWS_26573619_Chip-Seq_HEK293_Human	1.90787565
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83576305
25	CIITA_25753668_ChIP-Seq_RAJI_Human	1.70351279
26	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.64607183
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.62245832
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59188567
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58742436
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56079389
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.55997458
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.55306929
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47145980
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42125242
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.41085587
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40741259
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.37383059
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31803719
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30208726
40	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.29887984
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.29100910
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.27456928
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26799556
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26799556
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26093298
46	AR_20517297_ChIP-Seq_VCAP_Human	1.25847802
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.24529308
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22831472
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21821473
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.21711474
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21671709
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19029747
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.18452705
54	DCP1A_22483619_ChIP-Seq_HELA_Human	1.15337832
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.14319095
56	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.13824775
57	P53_21459846_ChIP-Seq_SAOS-2_Human	1.13332598
58	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.12264242
59	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11868163
60	NCOR_22424771_ChIP-Seq_293T_Human	1.11103455
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09006953
62	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.08825543
63	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.07754153
64	ERA_21632823_ChIP-Seq_H3396_Human	1.07219998
65	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.06345499
66	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.06011623
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05437278
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05183802
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04540518
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.03442593
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.03224439
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02564433
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02469558
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02397185
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02397185
76	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01752305
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01309323
78	P300_19829295_ChIP-Seq_ESCs_Human	0.99173583
79	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.98474841
80	AR_21572438_ChIP-Seq_LNCaP_Human	0.97970760
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97823937
82	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.97551503
83	STAT1_20625510_ChIP-Seq_HELA_Human	0.96480421
84	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96243794
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95548906
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.94162284
87	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.94024546
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93893847
89	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92953841
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92845567
91	FUS_26573619_Chip-Seq_HEK293_Human	0.91666609
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.91433667
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.90607596
94	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90566525
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.90239823
96	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.89300149
97	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.88049239
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87713758
99	OCT4_19829295_ChIP-Seq_ESCs_Human	0.87493016
100	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.87060395

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	6.37536283
2	MP0002163_abnormal_gland_morphology	3.51105854
3	MP0005646_abnormal_pituitary_gland	3.43729859
4	MP0003183_abnormal_peptide_metabolism	2.94078789
5	MP0005670_abnormal_white_adipose	2.77471640
6	MP0003011_delayed_dark_adaptation	2.52538826
7	MP0005551_abnormal_eye_electrophysiolog	2.36324807
8	MP0002638_abnormal_pupillary_reflex	2.34510512
9	MP0002102_abnormal_ear_morphology	2.31170911
10	MP0006292_abnormal_olfactory_placode	2.14046511
11	MP0005084_abnormal_gallbladder_morpholo	2.09529880
12	MP0002138_abnormal_hepatobiliary_system	1.96680848
13	MP0000569_abnormal_digit_pigmentation	1.92655944
14	MP0005083_abnormal_biliary_tract	1.91042982
15	MP0003718_maternal_effect	1.90732213
16	MP0003950_abnormal_plasma_membrane	1.85726310
17	MP0002736_abnormal_nociception_after	1.82858138
18	MP0010094_abnormal_chromosome_stability	1.82786612
19	MP0008872_abnormal_physiological_respon	1.79172454
20	MP0005377_hearing/vestibular/ear_phenot	1.73784674
21	MP0003878_abnormal_ear_physiology	1.73784674
22	MP0001764_abnormal_homeostasis	1.73453542
23	MP0003283_abnormal_digestive_organ	1.67789629
24	MP0008875_abnormal_xenobiotic_pharmacok	1.66509051
25	MP0005379_endocrine/exocrine_gland_phen	1.63074635
26	MP0003252_abnormal_bile_duct	1.62159983
27	MP0001968_abnormal_touch/_nociception	1.61642177
28	MP0008058_abnormal_DNA_repair	1.54942771
29	MP0004885_abnormal_endolymph	1.52913611
30	MP0001984_abnormal_olfaction	1.49252568
31	MP0003693_abnormal_embryo_hatching	1.48735188
32	MP0002234_abnormal_pharynx_morphology	1.47196430
33	MP0004142_abnormal_muscle_tone	1.45899272
34	MP0003959_abnormal_lean_body	1.45458147
35	MP0002837_dystrophic_cardiac_calcinosis	1.44271814
36	MP0000685_abnormal_immune_system	1.42884297
37	MP0004215_abnormal_myocardial_fiber	1.31702684
38	MP0000566_synostosis	1.28525102
39	MP0001485_abnormal_pinna_reflex	1.26774959
40	MP0002735_abnormal_chemical_nociception	1.25484562
41	MP0004742_abnormal_vestibular_system	1.25273865
42	MP0001293_anophthalmia	1.23695060
43	MP0002160_abnormal_reproductive_system	1.22970893
44	MP0005410_abnormal_fertilization	1.22255020
45	MP0004147_increased_porphyrin_level	1.21031431
46	MP0005253_abnormal_eye_physiology	1.19786205
47	MP0002272_abnormal_nervous_system	1.19715776
48	MP0009745_abnormal_behavioral_response	1.17699213
49	MP0006072_abnormal_retinal_apoptosis	1.16289907
50	MP0002733_abnormal_thermal_nociception	1.15746872
51	MP0001905_abnormal_dopamine_level	1.14880570
52	MP0005389_reproductive_system_phenotype	1.12412469
53	MP0001986_abnormal_taste_sensitivity	1.09383796
54	MP0001440_abnormal_grooming_behavior	1.03409984
55	MP0001486_abnormal_startle_reflex	0.99817290
56	MP0002928_abnormal_bile_duct	0.97674634
57	MP0008775_abnormal_heart_ventricle	0.96954547
58	MP0006035_abnormal_mitochondrial_morpho	0.96696278
59	MP0004133_heterotaxia	0.96503383
60	MP0000427_abnormal_hair_cycle	0.95136767
61	MP0001970_abnormal_pain_threshold	0.93543713
62	MP0008789_abnormal_olfactory_epithelium	0.93506597
63	MP0005195_abnormal_posterior_eye	0.92220197
64	MP0002751_abnormal_autonomic_nervous	0.91865364
65	MP0000383_abnormal_hair_follicle	0.90228981
66	MP0003186_abnormal_redox_activity	0.89628064
67	MP0002876_abnormal_thyroid_physiology	0.86987909
68	MP0001502_abnormal_circadian_rhythm	0.84485578
69	MP0009764_decreased_sensitivity_to	0.84041248
70	MP0001501_abnormal_sleep_pattern	0.82621135
71	MP0001346_abnormal_lacrimal_gland	0.81027460
72	MP0001835_abnormal_antigen_presentation	0.80289364
73	MP0002067_abnormal_sensory_capabilities	0.80284364
74	MP0000778_abnormal_nervous_system	0.78582065
75	MP0005332_abnormal_amino_acid	0.78461302
76	MP0003646_muscle_fatigue	0.77869872
77	MP0003121_genomic_imprinting	0.77383130
78	MP0009046_muscle_twitch	0.77240759
79	MP0009250_abnormal_appendicular_skeleto	0.76688891
80	MP0006036_abnormal_mitochondrial_physio	0.76469615
81	MP0005448_abnormal_energy_balance	0.76195148
82	MP0002064_seizures	0.75822944
83	MP0006276_abnormal_autonomic_nervous	0.75160081
84	MP0002557_abnormal_social/conspecific_i	0.72465164
85	MP0002166_altered_tumor_susceptibility	0.71942320
86	MP0003787_abnormal_imprinting	0.68918351
87	MP0001529_abnormal_vocalization	0.68918047
88	MP0000631_abnormal_neuroendocrine_gland	0.67834221
89	MP0009379_abnormal_foot_pigmentation	0.67284991
90	MP0005671_abnormal_response_to	0.66840132
91	MP0003567_abnormal_fetal_cardiomyocyte	0.66080605
92	MP0008995_early_reproductive_senescence	0.65454963
93	MP0001929_abnormal_gametogenesis	0.65389409
94	MP0003698_abnormal_male_reproductive	0.64746224
95	MP0002572_abnormal_emotion/affect_behav	0.63782925
96	MP0001324_abnormal_eye_pigmentation	0.63022810
97	MP0005499_abnormal_olfactory_system	0.59690298
98	MP0005394_taste/olfaction_phenotype	0.59690298
99	MP0001919_abnormal_reproductive_system	0.58861094
100	MP0001765_abnormal_ion_homeostasis	0.58397846

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.55279372
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.38457835
3	Absent/shortened dynein arms (HP:0200106)	4.38457835
4	Acute encephalopathy (HP:0006846)	4.07987958
5	Abnormality of midbrain morphology (HP:0002418)	4.06581737
6	Molar tooth sign on MRI (HP:0002419)	4.06581737
7	Acute necrotizing encephalopathy (HP:0006965)	4.01427966
8	Congenital stationary night blindness (HP:0007642)	3.99117208
9	Abnormality of the renal cortex (HP:0011035)	3.86544374
10	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.83425057
11	Abnormality of alanine metabolism (HP:0010916)	3.83425057
12	Hyperalaninemia (HP:0003348)	3.83425057
13	Nephronophthisis (HP:0000090)	3.82212364
14	Abnormality of the renal medulla (HP:0100957)	3.68987954
15	Tubular atrophy (HP:0000092)	3.50101520
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.45781812
17	Progressive macrocephaly (HP:0004481)	3.41314907
18	Nasal polyposis (HP:0100582)	3.38167353
19	Abnormal respiratory epithelium morphology (HP:0012253)	3.35691683
20	Abnormal respiratory motile cilium morphology (HP:0005938)	3.35691683
21	Abnormal mitochondria in muscle tissue (HP:0008316)	3.28619559
22	Abnormality of cells of the erythroid lineage (HP:0012130)	3.24143624
23	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.08178406
24	Abnormal number of erythroid precursors (HP:0012131)	3.05204263
25	Dry hair (HP:0011359)	2.99621213
26	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.94372387
27	Asplenia (HP:0001746)	2.85471267
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.81934188
29	Abnormality of the nasal mucosa (HP:0000433)	2.79373656
30	Chorioretinal atrophy (HP:0000533)	2.79182921
31	Abnormal number of incisors (HP:0011064)	2.78214635
32	Renal cortical cysts (HP:0000803)	2.75027670
33	Pancreatic cysts (HP:0001737)	2.70742134
34	Abnormal drinking behavior (HP:0030082)	2.69413015
35	Polydipsia (HP:0001959)	2.69413015
36	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.63376304
37	Panhypogammaglobulinemia (HP:0003139)	2.60221256
38	Optic disc pallor (HP:0000543)	2.58288499
39	Agammaglobulinemia (HP:0004432)	2.57122251
40	Abnormal ciliary motility (HP:0012262)	2.56901853
41	Tinnitus (HP:0000360)	2.55633526
42	High pitched voice (HP:0001620)	2.54819856
43	Prolonged neonatal jaundice (HP:0006579)	2.53424940
44	Mitochondrial inheritance (HP:0001427)	2.51190054
45	Leukodystrophy (HP:0002415)	2.51101446
46	Supernumerary spleens (HP:0009799)	2.49779171
47	Neuroendocrine neoplasm (HP:0100634)	2.48359255
48	Tubulointerstitial nephritis (HP:0001970)	2.45496379
49	Tubulointerstitial abnormality (HP:0001969)	2.37025520
50	Hyperglycinemia (HP:0002154)	2.34532679
51	Stenosis of the external auditory canal (HP:0000402)	2.34062300
52	Increased CSF lactate (HP:0002490)	2.33889105
53	Oligodactyly (hands) (HP:0001180)	2.32371255
54	Cerebral edema (HP:0002181)	2.30069953
55	Papilledema (HP:0001085)	2.30066089
56	IgG deficiency (HP:0004315)	2.26855121
57	Pustule (HP:0200039)	2.23745324
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.19475207
59	Hypoproteinemia (HP:0003075)	2.07668361
60	Birth length less than 3rd percentile (HP:0003561)	2.05353462
61	Absent thumb (HP:0009777)	2.04441290
62	Pancreatic fibrosis (HP:0100732)	2.02317165
63	Abnormal pupillary function (HP:0007686)	2.02007578
64	Polyuria (HP:0000103)	2.01827557
65	Abnormal respiratory motile cilium physiology (HP:0012261)	2.01710076
66	Tubulointerstitial fibrosis (HP:0005576)	2.01419033
67	Partial agenesis of the corpus callosum (HP:0001338)	1.95461500
68	Hyperglycinuria (HP:0003108)	1.92955815
69	Abnormal rod and cone electroretinograms (HP:0008323)	1.92859308
70	Chronic bronchitis (HP:0004469)	1.91113858
71	Hypoplasia of the pons (HP:0012110)	1.90134007
72	Medial flaring of the eyebrow (HP:0010747)	1.89570668
73	Recurrent cutaneous fungal infections (HP:0011370)	1.89132594
74	Chronic mucocutaneous candidiasis (HP:0002728)	1.89132594
75	Type I transferrin isoform profile (HP:0003642)	1.87387252
76	Rhinitis (HP:0012384)	1.86654376
77	Abnormality of the pons (HP:0007361)	1.86043595
78	Pigmentary retinal degeneration (HP:0001146)	1.85672140
79	Meckel diverticulum (HP:0002245)	1.85201030
80	Stomatitis (HP:0010280)	1.84199889
81	Proximal tubulopathy (HP:0000114)	1.83669402
82	Abnormality of the ileum (HP:0001549)	1.83085023
83	Esophageal atresia (HP:0002032)	1.82085322
84	Generalized aminoaciduria (HP:0002909)	1.79673276
85	Increased serum pyruvate (HP:0003542)	1.77033902
86	Abnormality of serum amino acid levels (HP:0003112)	1.76015037
87	Microretrognathia (HP:0000308)	1.75204374
88	Fair hair (HP:0002286)	1.73020453
89	Lactic acidosis (HP:0003128)	1.72676346
90	Cystic liver disease (HP:0006706)	1.72577114
91	Pendular nystagmus (HP:0012043)	1.71972003
92	Flat capital femoral epiphysis (HP:0003370)	1.71522966
93	Brushfield spots (HP:0001088)	1.71340348
94	Redundant skin (HP:0001582)	1.70106853
95	Lethargy (HP:0001254)	1.68851456
96	Abnormality of the preputium (HP:0100587)	1.67538196
97	Testicular atrophy (HP:0000029)	1.67534029
98	Flattened epiphyses (HP:0003071)	1.66126544
99	Bronchiectasis (HP:0002110)	1.66096129
100	Abnormal glycosylation (HP:0012345)	1.63103281

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMKK2	3.47497087
2	TLK1	2.38907836
3	TYRO3	2.35198812
4	NUAK1	2.33010303
5	FRK	2.31926723
6	SRPK1	2.24153966
7	EIF2AK3	2.23961108
8	PLK4	2.22097372
9	ADRBK2	2.22092618
10	CAMK1D	2.04107040
11	PLK2	1.97975086
12	BMPR1B	1.94687544
13	WNK4	1.93661484
14	DYRK2	1.81398182
15	VRK2	1.80386766
16	WNK3	1.74888027
17	TAF1	1.71739440
18	PTK2B	1.71684916
19	PRKCI	1.57663967
20	VRK1	1.56281125
21	RIPK1	1.55913523
22	MAPKAPK3	1.52172091
23	BCR	1.47851039
24	MAP3K13	1.47286083
25	CSNK1G3	1.46926946
26	MAP4K2	1.45417203
27	CAMK1G	1.44947505
28	ZAK	1.37943459
29	MAP2K6	1.36529450
30	PINK1	1.30718782
31	NME1	1.30099772
32	CSNK1G2	1.28863939
33	CSNK1A1L	1.28190311
34	TRIM28	1.27764139
35	GRK1	1.24478727
36	TXK	1.23901876
37	TIE1	1.21155103
38	BUB1	1.20760076
39	EIF2AK2	1.18925033
40	NEK1	1.18731854
41	BRSK1	1.16439369
42	BRSK2	1.13588487
43	PNCK	1.07922933
44	CSNK1G1	1.07535133
45	TNIK	1.07248001
46	PHKG2	1.05834695
47	PHKG1	1.05834695
48	EPHA3	1.03675347
49	TEC	1.02883938
50	MAPK13	1.01841121
51	LATS1	1.01773107
52	PLK3	0.99726239
53	PRKCG	0.99406644
54	STK38L	0.99178806
55	BCKDK	0.99025846
56	ACVR1B	0.97444743
57	KIT	0.96005952
58	MKNK2	0.92777227
59	ADRBK1	0.90705011
60	WNK1	0.83974559
61	MAP2K7	0.83616204
62	CAMKK1	0.80082519
63	NEK2	0.77272350
64	STK39	0.75659006
65	GRK5	0.75527690
66	PRKCQ	0.75463913
67	PAK6	0.72420482
68	DAPK2	0.72201334
69	MAP3K3	0.71521170
70	TGFBR1	0.71111930
71	MST4	0.70557093
72	PKN1	0.69248590
73	SYK	0.67024141
74	PRKCE	0.63876357
75	RPS6KA5	0.63175991
76	STK3	0.60453684
77	STK16	0.60274777
78	PBK	0.59967725
79	PLK1	0.56377681
80	RPS6KA4	0.56247244
81	WEE1	0.55540478
82	PRKCH	0.55289305
83	MAP3K7	0.55198388
84	CAMK1	0.53115395
85	FLT3	0.51631960
86	IKBKB	0.50519225
87	SIK2	0.48992245
88	TSSK6	0.46150978
89	ALK	0.45043338
90	OXSR1	0.44180217
91	ATR	0.40771971
92	STK10	0.40480250
93	CAMK2A	0.38925680
94	CHEK2	0.38611107
95	IRAK1	0.38610948
96	CCNB1	0.37096466
97	PIM2	0.34958996
98	INSRR	0.33857993
99	PRKAA2	0.33223489
100	KDR	0.32114376

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.74605316
2	Ribosome_Homo sapiens_hsa03010	3.22582190
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.03525247
4	Phototransduction_Homo sapiens_hsa04744	2.89245367
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.56844987
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.55861202
7	RNA polymerase_Homo sapiens_hsa03020	2.52950779
8	Homologous recombination_Homo sapiens_hsa03440	2.44362409
9	Parkinsons disease_Homo sapiens_hsa05012	2.41156373
10	One carbon pool by folate_Homo sapiens_hsa00670	2.31234431
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.25243197
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.10106480
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.06046451
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.97024053
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.91767271
16	DNA replication_Homo sapiens_hsa03030	1.91075297
17	Propanoate metabolism_Homo sapiens_hsa00640	1.75613864
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72723727
19	Mismatch repair_Homo sapiens_hsa03430	1.69722199
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.66860163
21	Basal transcription factors_Homo sapiens_hsa03022	1.62971675
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.61534992
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55696799
24	Huntingtons disease_Homo sapiens_hsa05016	1.51907565
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51389480
26	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.46730618
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.39932576
28	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.38478249
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.37600684
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36065549
31	Asthma_Homo sapiens_hsa05310	1.34078889
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33609934
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.33307018
34	Peroxisome_Homo sapiens_hsa04146	1.30803470
35	Allograft rejection_Homo sapiens_hsa05330	1.26686424
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26082686
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24144159
38	Alzheimers disease_Homo sapiens_hsa05010	1.23303445
39	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.20857345
40	Butanoate metabolism_Homo sapiens_hsa00650	1.20293556
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.17738749
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17147269
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16897405
44	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.16231597
45	Protein export_Homo sapiens_hsa03060	1.15497827
46	Type I diabetes mellitus_Homo sapiens_hsa04940	1.10401990
47	Purine metabolism_Homo sapiens_hsa00230	1.09363048
48	RNA degradation_Homo sapiens_hsa03018	1.00961608
49	Base excision repair_Homo sapiens_hsa03410	0.99530030
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96664081
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94836012
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.92772414
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90715095
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85869009
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80262740
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78888545
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74082363
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.72784322
59	Olfactory transduction_Homo sapiens_hsa04740	0.72765374
60	Spliceosome_Homo sapiens_hsa03040	0.71442901
61	Melanoma_Homo sapiens_hsa05218	0.69255886
62	Serotonergic synapse_Homo sapiens_hsa04726	0.66998483
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.66697319
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.65372217
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.62723759
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61729593
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61171067
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58940634
69	Morphine addiction_Homo sapiens_hsa05032	0.57915225
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57751289
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52446308
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51785178
73	Metabolic pathways_Homo sapiens_hsa01100	0.51192346
74	Nicotine addiction_Homo sapiens_hsa05033	0.51044631
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45812766
76	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45697896
77	Glutathione metabolism_Homo sapiens_hsa00480	0.43526657
78	Circadian rhythm_Homo sapiens_hsa04710	0.43052653
79	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.41877967
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.40050497
81	RNA transport_Homo sapiens_hsa03013	0.40043752
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39804059
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38994561
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.38620380
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35064334
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33754087
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31521874
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28726305
89	Taste transduction_Homo sapiens_hsa04742	0.27966413
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.26015749
91	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.25875487
92	Insulin secretion_Homo sapiens_hsa04911	0.24864195
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.22797100
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22562659
95	Retinol metabolism_Homo sapiens_hsa00830	0.21925540
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.18981152
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18558284
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.18504457
99	Mineral absorption_Homo sapiens_hsa04978	0.17892736
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.17860503

HMGB1P48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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