HMGB1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14242507
2ATP synthesis coupled proton transport (GO:0015986)4.88955061
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.88955061
4chaperone-mediated protein transport (GO:0072321)4.83948556
5chromatin remodeling at centromere (GO:0031055)4.82039316
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.71127809
7maturation of SSU-rRNA (GO:0030490)4.63316950
8ribosomal small subunit biogenesis (GO:0042274)4.60665136
9CENP-A containing nucleosome assembly (GO:0034080)4.60443728
10protein neddylation (GO:0045116)4.58275198
11ribosomal small subunit assembly (GO:0000028)4.32731962
12viral transcription (GO:0019083)4.27958129
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.26155548
14translational termination (GO:0006415)4.24092388
15DNA replication checkpoint (GO:0000076)4.17930617
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15567695
17protein complex biogenesis (GO:0070271)4.12685158
18mitochondrial respiratory chain complex assembly (GO:0033108)4.02445316
19kinetochore organization (GO:0051383)3.99041143
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96980084
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.96980084
22NADH dehydrogenase complex assembly (GO:0010257)3.96980084
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.88897720
24histone exchange (GO:0043486)3.88046674
25cotranslational protein targeting to membrane (GO:0006613)3.87531888
26protein targeting to ER (GO:0045047)3.82694059
27respiratory electron transport chain (GO:0022904)3.81041875
28DNA deamination (GO:0045006)3.79523507
29electron transport chain (GO:0022900)3.77193730
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74440455
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.73016940
32kinetochore assembly (GO:0051382)3.70204581
33ribosomal large subunit biogenesis (GO:0042273)3.69801026
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66438214
35translational elongation (GO:0006414)3.65886604
36protein localization to endoplasmic reticulum (GO:0070972)3.59978582
37DNA replication-independent nucleosome assembly (GO:0006336)3.59784696
38DNA replication-independent nucleosome organization (GO:0034724)3.59784696
39pyrimidine nucleotide catabolic process (GO:0006244)3.52619823
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.48673792
41termination of RNA polymerase III transcription (GO:0006386)3.48673792
42regulation of mitochondrial translation (GO:0070129)3.46297853
43pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.42845756
44telomere maintenance via semi-conservative replication (GO:0032201)3.37325286
45cellular component biogenesis (GO:0044085)3.36926469
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.36204691
47translation (GO:0006412)3.35520934
48ribonucleoprotein complex biogenesis (GO:0022613)3.32112078
49replication fork processing (GO:0031297)3.30692595
50viral life cycle (GO:0019058)3.28963015
51cellular protein complex disassembly (GO:0043624)3.27551307
52translational initiation (GO:0006413)3.26826729
53rRNA processing (GO:0006364)3.25480563
54DNA strand elongation involved in DNA replication (GO:0006271)3.25437853
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22487702
56water-soluble vitamin biosynthetic process (GO:0042364)3.20223429
57rRNA metabolic process (GO:0016072)3.19784144
58DNA double-strand break processing (GO:0000729)3.13681305
59protein-cofactor linkage (GO:0018065)3.11594085
60DNA strand elongation (GO:0022616)3.07543017
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07040229
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07040229
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.05207934
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04859645
65DNA catabolic process, exonucleolytic (GO:0000738)3.03867572
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03599716
67regulation of mitotic spindle checkpoint (GO:1903504)3.03599716
68DNA replication-dependent nucleosome assembly (GO:0006335)3.03076926
69DNA replication-dependent nucleosome organization (GO:0034723)3.03076926
70cullin deneddylation (GO:0010388)3.02389894
71behavioral response to nicotine (GO:0035095)3.01158964
72base-excision repair, AP site formation (GO:0006285)3.00508749
73proteasome assembly (GO:0043248)3.00077286
74pseudouridine synthesis (GO:0001522)2.99109998
75maturation of 5.8S rRNA (GO:0000460)2.99038637
76respiratory chain complex IV assembly (GO:0008535)2.98743795
77cytochrome complex assembly (GO:0017004)2.97736480
78spliceosomal snRNP assembly (GO:0000387)2.96712383
79nucleotide-excision repair, DNA gap filling (GO:0006297)2.94249002
80DNA damage response, detection of DNA damage (GO:0042769)2.92300716
81regulation of DNA endoreduplication (GO:0032875)2.92208242
82telomere maintenance via recombination (GO:0000722)2.91877979
83DNA ligation (GO:0006266)2.89409277
84protein targeting to mitochondrion (GO:0006626)2.89186014
85mitotic recombination (GO:0006312)2.88681497
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88379619
87protein complex disassembly (GO:0043241)2.88165206
88macromolecular complex disassembly (GO:0032984)2.83088604
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82881866
90protein deneddylation (GO:0000338)2.82597648
91establishment of integrated proviral latency (GO:0075713)2.80029375
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78496395
93centriole replication (GO:0007099)2.77655292
94establishment of protein localization to mitochondrion (GO:0072655)2.76714905
95GTP biosynthetic process (GO:0006183)2.76360587
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76050771
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75245183
98negative regulation of ligase activity (GO:0051352)2.75245183
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74976736
100tRNA processing (GO:0008033)2.72628778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.05600065
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82395983
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.22094697
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.97756472
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.89026783
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.35027121
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.28563242
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17772052
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10724864
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.95606281
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76842153
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71977763
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67130417
14ELK1_19687146_ChIP-ChIP_HELA_Human2.66402330
15VDR_23849224_ChIP-Seq_CD4+_Human2.55217819
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44727442
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42948410
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.42324761
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42163499
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39606889
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38980865
22FOXP3_21729870_ChIP-Seq_TREG_Human2.27021882
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24856102
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19175647
25MYC_18940864_ChIP-ChIP_HL60_Human2.15113946
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14919277
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93411930
28TTF2_22483619_ChIP-Seq_HELA_Human1.93258033
29ZNF274_21170338_ChIP-Seq_K562_Hela1.91931505
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87258660
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81844766
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.81620473
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.79869627
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78591724
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78140747
36EWS_26573619_Chip-Seq_HEK293_Human1.73637593
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72262728
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71730787
39GABP_19822575_ChIP-Seq_HepG2_Human1.71570638
40XRN2_22483619_ChIP-Seq_HELA_Human1.69997894
41EZH2_22144423_ChIP-Seq_EOC_Human1.66573602
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64890021
43VDR_22108803_ChIP-Seq_LS180_Human1.64262832
44IRF1_19129219_ChIP-ChIP_H3396_Human1.62794329
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61818951
46DCP1A_22483619_ChIP-Seq_HELA_Human1.57715871
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55526543
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54614796
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45549472
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44994910
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44327841
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43958346
53FUS_26573619_Chip-Seq_HEK293_Human1.42205267
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.41189553
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39590426
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.37046337
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.36152712
58IGF1R_20145208_ChIP-Seq_DFB_Human1.21408182
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20578371
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12960810
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.12895282
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12666486
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11436164
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10075860
65TP53_22573176_ChIP-Seq_HFKS_Human1.09251735
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.09034367
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08587990
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.06298391
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05679989
70KDM5A_27292631_Chip-Seq_BREAST_Human1.02693675
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02183174
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02024565
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00884228
74SALL1_21062744_ChIP-ChIP_HESCs_Human0.98693261
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95483969
76CIITA_25753668_ChIP-Seq_RAJI_Human0.94814066
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94744431
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94510471
79CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93715083
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91487692
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89028864
82AR_21909140_ChIP-Seq_LNCAP_Human0.89000432
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88856338
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.88752060
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85636418
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83541269
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83498752
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.83498752
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82623327
90P300_19829295_ChIP-Seq_ESCs_Human0.82321657
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82285097
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82182627
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82061491
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79958166
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76219275
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76024421
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75793799
98NCOR_22424771_ChIP-Seq_293T_Human0.75712071
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75638476
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.74409544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.45480550
2MP0010094_abnormal_chromosome_stability3.45184181
3MP0008877_abnormal_DNA_methylation3.41974890
4MP0009379_abnormal_foot_pigmentation3.29582915
5MP0003693_abnormal_embryo_hatching3.14874847
6MP0008058_abnormal_DNA_repair3.12731548
7MP0003787_abnormal_imprinting2.82471596
8MP0003111_abnormal_nucleus_morphology2.32398790
9MP0004957_abnormal_blastocyst_morpholog2.27399345
10MP0003806_abnormal_nucleotide_metabolis2.04227416
11MP0003077_abnormal_cell_cycle2.02603985
12MP0008789_abnormal_olfactory_epithelium1.99445089
13MP0002938_white_spotting1.99166117
14MP0001293_anophthalmia1.97655527
15MP0006072_abnormal_retinal_apoptosis1.95409028
16MP0002736_abnormal_nociception_after1.84030304
17MP0003121_genomic_imprinting1.80795282
18MP0003718_maternal_effect1.75813730
19MP0008932_abnormal_embryonic_tissue1.75657169
20MP0001529_abnormal_vocalization1.75208379
21MP0002163_abnormal_gland_morphology1.74555850
22MP0002102_abnormal_ear_morphology1.72042854
23MP0005084_abnormal_gallbladder_morpholo1.67796427
24MP0005499_abnormal_olfactory_system1.56803509
25MP0005394_taste/olfaction_phenotype1.56803509
26MP0005645_abnormal_hypothalamus_physiol1.55905089
27MP0008872_abnormal_physiological_respon1.51941684
28MP0005646_abnormal_pituitary_gland1.49383727
29MP0000631_abnormal_neuroendocrine_gland1.47545015
30MP0003011_delayed_dark_adaptation1.46977906
31MP0001968_abnormal_touch/_nociception1.46793879
32MP0006036_abnormal_mitochondrial_physio1.45102879
33MP0008007_abnormal_cellular_replicative1.42933437
34MP0002638_abnormal_pupillary_reflex1.42739863
35MP0003786_premature_aging1.41775645
36MP0009046_muscle_twitch1.41236150
37MP0002160_abnormal_reproductive_system1.41207368
38MP0001485_abnormal_pinna_reflex1.37042184
39MP0000372_irregular_coat_pigmentation1.35518028
40MP0003186_abnormal_redox_activity1.34875116
41MP0008057_abnormal_DNA_replication1.34349718
42MP0005389_reproductive_system_phenotype1.32974288
43MP0005551_abnormal_eye_electrophysiolog1.32964847
44MP0002837_dystrophic_cardiac_calcinosis1.32838576
45MP0001919_abnormal_reproductive_system1.30809238
46MP0003123_paternal_imprinting1.30749717
47MP0000049_abnormal_middle_ear1.26582345
48MP0004142_abnormal_muscle_tone1.24957949
49MP0002653_abnormal_ependyma_morphology1.16946335
50MP0002210_abnormal_sex_determination1.16607993
51MP0001905_abnormal_dopamine_level1.16138140
52MP0004133_heterotaxia1.16108581
53MP0004147_increased_porphyrin_level1.10699128
54MP0005253_abnormal_eye_physiology1.10190485
55MP0003937_abnormal_limbs/digits/tail_de1.09951588
56MP0008995_early_reproductive_senescence1.09868664
57MP0003315_abnormal_perineum_morphology1.06843558
58MP0005671_abnormal_response_to1.06212538
59MP0006035_abnormal_mitochondrial_morpho1.04620730
60MP0002095_abnormal_skin_pigmentation1.03561459
61MP0001929_abnormal_gametogenesis1.02191787
62MP0003136_yellow_coat_color1.02144639
63MP0003567_abnormal_fetal_cardiomyocyte1.01866573
64MP0002234_abnormal_pharynx_morphology1.01670673
65MP0001286_abnormal_eye_development1.00522179
66MP0001188_hyperpigmentation0.98315491
67MP0006276_abnormal_autonomic_nervous0.96762111
68MP0003880_abnormal_central_pattern0.96470463
69MP0005379_endocrine/exocrine_gland_phen0.96249300
70MP0005195_abnormal_posterior_eye0.90922610
71MP0003938_abnormal_ear_development0.90875198
72MP0003122_maternal_imprinting0.90548931
73MP0009697_abnormal_copulation0.89444520
74MP0000653_abnormal_sex_gland0.89314167
75MP0001145_abnormal_male_reproductive0.89313630
76MP0005075_abnormal_melanosome_morpholog0.88077542
77MP0003890_abnormal_embryonic-extraembry0.87641137
78MP0004145_abnormal_muscle_electrophysio0.87463627
79MP0002233_abnormal_nose_morphology0.87023773
80MP0002272_abnormal_nervous_system0.86632164
81MP0001984_abnormal_olfaction0.86119972
82MP0002752_abnormal_somatic_nervous0.82491592
83MP0002277_abnormal_respiratory_mucosa0.82061331
84MP0009745_abnormal_behavioral_response0.81632140
85MP0008875_abnormal_xenobiotic_pharmacok0.81113142
86MP0000778_abnormal_nervous_system0.77810557
87MP0002876_abnormal_thyroid_physiology0.77362248
88MP0003698_abnormal_male_reproductive0.76571710
89MP0001119_abnormal_female_reproductive0.74740936
90MP0005391_vision/eye_phenotype0.74097302
91MP0003646_muscle_fatigue0.72619333
92MP0005410_abnormal_fertilization0.72201484
93MP0002184_abnormal_innervation0.71756608
94MP0002751_abnormal_autonomic_nervous0.70567585
95MP0010030_abnormal_orbit_morphology0.70188521
96MP0002557_abnormal_social/conspecific_i0.70159558
97MP0001764_abnormal_homeostasis0.69817205
98MP0001727_abnormal_embryo_implantation0.68907815
99MP0002735_abnormal_chemical_nociception0.67351417
100MP0002733_abnormal_thermal_nociception0.62559567

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.85246292
2Abnormal mitochondria in muscle tissue (HP:0008316)4.40322262
3Acute encephalopathy (HP:0006846)4.21919932
4Progressive macrocephaly (HP:0004481)3.96729350
5Mitochondrial inheritance (HP:0001427)3.93960094
6Increased CSF lactate (HP:0002490)3.69763053
7Abnormality of cells of the erythroid lineage (HP:0012130)3.38295029
8Increased hepatocellular lipid droplets (HP:0006565)3.37008896
9Reticulocytopenia (HP:0001896)3.34389090
10Cerebral edema (HP:0002181)3.23197609
11Abnormality of midbrain morphology (HP:0002418)3.22920933
12Molar tooth sign on MRI (HP:0002419)3.22920933
13Lipid accumulation in hepatocytes (HP:0006561)3.16725584
14Macrocytic anemia (HP:0001972)3.14275088
15Hepatocellular necrosis (HP:0001404)3.12138969
16Abnormal number of erythroid precursors (HP:0012131)3.07695744
173-Methylglutaconic aciduria (HP:0003535)3.05511976
18Pancreatic cysts (HP:0001737)3.05012471
19Pancreatic fibrosis (HP:0100732)2.96895655
20Hepatic necrosis (HP:0002605)2.93574291
21Colon cancer (HP:0003003)2.86202143
22Renal Fanconi syndrome (HP:0001994)2.78741658
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73360121
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73360121
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66625132
26Abnormality of the labia minora (HP:0012880)2.65520724
27Increased serum lactate (HP:0002151)2.62743081
28True hermaphroditism (HP:0010459)2.62542304
29Chromsome breakage (HP:0040012)2.62358680
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.59068912
31Nephronophthisis (HP:0000090)2.52007387
32Birth length less than 3rd percentile (HP:0003561)2.51827262
33Increased intramyocellular lipid droplets (HP:0012240)2.51009748
34Lactic acidosis (HP:0003128)2.47461763
35Meckel diverticulum (HP:0002245)2.46610572
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44503345
37Optic disc pallor (HP:0000543)2.43052629
38Absent thumb (HP:0009777)2.42079413
39Leukodystrophy (HP:0002415)2.41752155
40Abnormality of the ileum (HP:0001549)2.41699843
41Medial flaring of the eyebrow (HP:0010747)2.39162375
42Abnormality of chromosome stability (HP:0003220)2.28988614
43Methylmalonic acidemia (HP:0002912)2.26821045
44Hyperglycinemia (HP:0002154)2.25715432
45Volvulus (HP:0002580)2.24435120
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18969409
47Abnormality of alanine metabolism (HP:0010916)2.18969409
48Hyperalaninemia (HP:0003348)2.18969409
49Pallor (HP:0000980)2.18361168
50Congenital, generalized hypertrichosis (HP:0004540)2.18311183
51Pendular nystagmus (HP:0012043)2.16582710
52Congenital stationary night blindness (HP:0007642)2.15632981
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14336816
54Sclerocornea (HP:0000647)2.14168053
55Abnormality of the preputium (HP:0100587)2.12575095
56Septo-optic dysplasia (HP:0100842)2.11625527
57Exertional dyspnea (HP:0002875)2.10619232
58Abnormality of renal resorption (HP:0011038)2.09289641
59Triphalangeal thumb (HP:0001199)2.08783893
60Lethargy (HP:0001254)2.08206770
61Exercise intolerance (HP:0003546)2.06999395
62Respiratory failure (HP:0002878)2.05751291
63Methylmalonic aciduria (HP:0012120)2.01762712
64Increased muscle lipid content (HP:0009058)2.00859756
65Anencephaly (HP:0002323)1.97837550
66Abnormality of the renal medulla (HP:0100957)1.95272141
67Rib fusion (HP:0000902)1.93476807
68Ectopic kidney (HP:0000086)1.92635753
69Gait imbalance (HP:0002141)1.92624764
70Renal cortical cysts (HP:0000803)1.92166642
71Patellar aplasia (HP:0006443)1.90454355
72Aplasia/Hypoplasia of the patella (HP:0006498)1.87681937
73Abnormality of the renal cortex (HP:0011035)1.84070533
74Abnormality of serum amino acid levels (HP:0003112)1.82685582
75Horseshoe kidney (HP:0000085)1.82559965
76Cleft eyelid (HP:0000625)1.82311392
77Pancytopenia (HP:0001876)1.79477757
78Congenital primary aphakia (HP:0007707)1.79385204
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78520623
80Sloping forehead (HP:0000340)1.78122794
81Aplastic anemia (HP:0001915)1.75519808
82Hypoplasia of the pons (HP:0012110)1.74803489
83Cystic liver disease (HP:0006706)1.74418274
84Microretrognathia (HP:0000308)1.74373985
85Abnormality of urine glucose concentration (HP:0011016)1.73154658
86Glycosuria (HP:0003076)1.73154658
87Supernumerary spleens (HP:0009799)1.70177671
88Nephrogenic diabetes insipidus (HP:0009806)1.69879082
89Oligodactyly (hands) (HP:0001180)1.69828674
90Respiratory difficulties (HP:0002880)1.69133163
91Duodenal stenosis (HP:0100867)1.68990999
92Small intestinal stenosis (HP:0012848)1.68990999
93Adrenal hypoplasia (HP:0000835)1.68440323
94Abnormal number of incisors (HP:0011064)1.67553572
95Type I transferrin isoform profile (HP:0003642)1.67161499
96Abnormality of the pons (HP:0007361)1.65743747
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65393789
98X-linked dominant inheritance (HP:0001423)1.65338013
99Postaxial foot polydactyly (HP:0001830)1.65125005
100IgG deficiency (HP:0004315)1.64492620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.04776771
2TLK13.69395110
3ZAK3.43187848
4VRK23.11313630
5BUB12.82176187
6STK162.72350392
7VRK12.62059871
8NUAK12.55962833
9PLK42.16512076
10NEK12.04808259
11MAP4K22.01815941
12SRPK11.93391415
13BMPR1B1.90712790
14MKNK21.88778869
15PLK31.86075972
16BCKDK1.83846677
17MST41.83098219
18WEE11.65294781
19DYRK21.58585149
20MKNK11.57424044
21WNK31.56750093
22TTK1.51626703
23PLK11.48538005
24EIF2AK11.40879963
25WNK41.40097142
26MAP2K71.37152085
27TNIK1.32263130
28ADRBK21.31945863
29BRSK21.27797396
30CHEK21.24602956
31TAF11.22674595
32TRIM281.22021284
33CDK191.20784694
34GRK11.19535395
35AURKB1.19301406
36AURKA1.16723550
37NME11.08507202
38PNCK1.07530342
39MAP3K41.07316138
40ATR1.06564572
41EIF2AK31.06548494
42NEK21.05966242
43MAPK130.97136863
44FRK0.96220742
45OXSR10.95407159
46PLK20.95285647
47CCNB10.87436503
48STK390.83695425
49RPS6KA50.81691449
50PASK0.81304882
51CSNK1G30.80274277
52EIF2AK20.79183743
53TAOK30.74706064
54CSNK2A20.73449104
55TSSK60.73220109
56CSNK1G20.72757987
57CSNK1G10.72697324
58PBK0.69496782
59INSRR0.67867232
60PRKCG0.67339127
61CSNK2A10.67112805
62ATM0.66687040
63BRSK10.66271610
64PINK10.64997085
65CHEK10.64321379
66CDK80.63989762
67MAP3K120.60050136
68TEC0.59417645
69NME20.57875460
70MINK10.56787887
71CSNK1E0.56561242
72TXK0.56025604
73PRKCI0.55696964
74RPS6KA40.54777788
75PHKG20.54171497
76PHKG10.54171497
77RPS6KB20.51277589
78CDK30.51212608
79DAPK30.50009891
80KDR0.49722607
81CASK0.49131563
82DYRK30.48851470
83CSNK1A1L0.46532247
84TIE10.45727211
85CDK70.43666586
86LIMK10.43286567
87PIK3CA0.42823484
88PDK20.42412705
89BCR0.41379320
90PRKCQ0.41023116
91MAPKAPK50.40647984
92EPHB20.40587177
93CDK140.40062475
94ALK0.39622319
95ABL20.38771678
96ADRBK10.37770615
97TESK20.36734526
98CDK10.36447518
99PRKDC0.35394806
100STK40.35121287

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.30805116
2Oxidative phosphorylation_Homo sapiens_hsa001903.59876080
3Proteasome_Homo sapiens_hsa030503.42589654
4DNA replication_Homo sapiens_hsa030303.25597133
5Mismatch repair_Homo sapiens_hsa034303.24652036
6Parkinsons disease_Homo sapiens_hsa050123.14358052
7Homologous recombination_Homo sapiens_hsa034403.00007860
8Protein export_Homo sapiens_hsa030602.90468637
9RNA polymerase_Homo sapiens_hsa030202.81011598
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39889386
11Fanconi anemia pathway_Homo sapiens_hsa034602.24096965
12Spliceosome_Homo sapiens_hsa030402.22449477
13Huntingtons disease_Homo sapiens_hsa050162.21484261
14Base excision repair_Homo sapiens_hsa034102.14491618
15Nucleotide excision repair_Homo sapiens_hsa034202.07088799
16Alzheimers disease_Homo sapiens_hsa050101.97629446
17One carbon pool by folate_Homo sapiens_hsa006701.94951977
18RNA degradation_Homo sapiens_hsa030181.90808811
19Pyrimidine metabolism_Homo sapiens_hsa002401.83613802
20Basal transcription factors_Homo sapiens_hsa030221.77342424
21Non-homologous end-joining_Homo sapiens_hsa034501.76735781
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73822312
23RNA transport_Homo sapiens_hsa030131.70197307
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64799476
25Cardiac muscle contraction_Homo sapiens_hsa042601.52908192
26Systemic lupus erythematosus_Homo sapiens_hsa053221.51814879
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46957535
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34719502
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33184132
30Purine metabolism_Homo sapiens_hsa002301.24709954
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14880867
32Cell cycle_Homo sapiens_hsa041101.14143688
33Propanoate metabolism_Homo sapiens_hsa006401.13043922
34Sulfur relay system_Homo sapiens_hsa041221.12515013
35Phototransduction_Homo sapiens_hsa047441.10925795
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09723448
37Folate biosynthesis_Homo sapiens_hsa007901.08930985
38Asthma_Homo sapiens_hsa053101.00573767
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98529579
40Primary immunodeficiency_Homo sapiens_hsa053400.95459441
41Linoleic acid metabolism_Homo sapiens_hsa005910.95367625
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95177830
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.92124353
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.88751425
45Alcoholism_Homo sapiens_hsa050340.88249726
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87960850
47Butanoate metabolism_Homo sapiens_hsa006500.85417236
48Pyruvate metabolism_Homo sapiens_hsa006200.77911303
49Selenocompound metabolism_Homo sapiens_hsa004500.73505948
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70264993
51Steroid biosynthesis_Homo sapiens_hsa001000.69516833
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68795901
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66638331
54Nitrogen metabolism_Homo sapiens_hsa009100.66249024
55Allograft rejection_Homo sapiens_hsa053300.64815970
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64172695
57mRNA surveillance pathway_Homo sapiens_hsa030150.63940062
58Autoimmune thyroid disease_Homo sapiens_hsa053200.63432076
59Metabolic pathways_Homo sapiens_hsa011000.63363534
60Peroxisome_Homo sapiens_hsa041460.62271163
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61199645
62Type I diabetes mellitus_Homo sapiens_hsa049400.60468584
63Tryptophan metabolism_Homo sapiens_hsa003800.58429392
64Fatty acid elongation_Homo sapiens_hsa000620.55583964
65Graft-versus-host disease_Homo sapiens_hsa053320.53939495
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52851471
67Caffeine metabolism_Homo sapiens_hsa002320.52348442
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.51666798
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51499850
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.49981366
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47915483
72Glutathione metabolism_Homo sapiens_hsa004800.47393799
73p53 signaling pathway_Homo sapiens_hsa041150.46168475
74Arachidonic acid metabolism_Homo sapiens_hsa005900.45483529
75Ether lipid metabolism_Homo sapiens_hsa005650.44611085
76Nicotine addiction_Homo sapiens_hsa050330.43665771
77Antigen processing and presentation_Homo sapiens_hsa046120.42141756
78Collecting duct acid secretion_Homo sapiens_hsa049660.40737382
79Chemical carcinogenesis_Homo sapiens_hsa052040.40012503
80Oocyte meiosis_Homo sapiens_hsa041140.39997347
81Epstein-Barr virus infection_Homo sapiens_hsa051690.39730625
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.37838553
83Retinol metabolism_Homo sapiens_hsa008300.37461233
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36522073
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32846711
86Olfactory transduction_Homo sapiens_hsa047400.32148829
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29713530
88beta-Alanine metabolism_Homo sapiens_hsa004100.25861975
89Fatty acid degradation_Homo sapiens_hsa000710.22866665
90Regulation of autophagy_Homo sapiens_hsa041400.22714080
91Fat digestion and absorption_Homo sapiens_hsa049750.22321253
92Basal cell carcinoma_Homo sapiens_hsa052170.20839556
93Vitamin B6 metabolism_Homo sapiens_hsa007500.19506581
94Hedgehog signaling pathway_Homo sapiens_hsa043400.18079405
95Sulfur metabolism_Homo sapiens_hsa009200.17994632
96Vitamin digestion and absorption_Homo sapiens_hsa049770.17047172
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.16368720
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15976250
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13678320
100Carbon metabolism_Homo sapiens_hsa012000.12707591

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