HMGB1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fibroblast migration (GO:0010761)6.59925800
2chemosensory behavior (GO:0007635)6.23547515
3negative regulation of transcription regulatory region DNA binding (GO:2000678)5.62025662
4ventricular trabecula myocardium morphogenesis (GO:0003222)5.52060886
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.48039252
6positive regulation of cell size (GO:0045793)5.45323829
7negative regulation of smooth muscle cell differentiation (GO:0051151)5.37675663
8Notch signaling involved in heart development (GO:0061314)5.36431617
9Rap protein signal transduction (GO:0032486)5.36311265
10negative regulation of dendrite morphogenesis (GO:0050774)5.25855394
11replication fork processing (GO:0031297)5.25498976
12protein K11-linked deubiquitination (GO:0035871)5.10182940
13cardiac right ventricle morphogenesis (GO:0003215)4.80738588
14keratinocyte development (GO:0003334)4.74843926
15resolution of meiotic recombination intermediates (GO:0000712)4.61627687
16negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.60995789
17coronary vasculature morphogenesis (GO:0060977)4.37961459
18regulation of vasculogenesis (GO:2001212)4.28306376
19tryptophan catabolic process (GO:0006569)4.16789387
20indole-containing compound catabolic process (GO:0042436)4.16789387
21indolalkylamine catabolic process (GO:0046218)4.16789387
22heart trabecula morphogenesis (GO:0061384)4.13278046
23heart valve formation (GO:0003188)4.08099549
24sensory perception of smell (GO:0007608)4.06107563
25cardiac epithelial to mesenchymal transition (GO:0060317)4.05959973
26regulation of mRNA 3-end processing (GO:0031440)4.03125366
27regulation of clathrin-mediated endocytosis (GO:2000369)3.98805211
28negative regulation of inclusion body assembly (GO:0090084)3.94092000
29regulation of inclusion body assembly (GO:0090083)3.93330675
30regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.87712723
31positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.87712723
32C4-dicarboxylate transport (GO:0015740)3.87273303
33maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.84817550
34estrogen metabolic process (GO:0008210)3.82898093
35cell wall macromolecule catabolic process (GO:0016998)3.80831803
36positive regulation of protein autophosphorylation (GO:0031954)3.79231336
37negative regulation of dendrite development (GO:2000171)3.78279234
38cochlea development (GO:0090102)3.75609131
39synapsis (GO:0007129)3.71391632
40somite development (GO:0061053)3.70394644
41regulation of smooth muscle cell differentiation (GO:0051150)3.64138369
42protein K6-linked ubiquitination (GO:0085020)3.60632259
43amine catabolic process (GO:0009310)3.55937361
44cellular biogenic amine catabolic process (GO:0042402)3.55937361
45nodal signaling pathway (GO:0038092)3.51977126
46response to inactivity (GO:0014854)3.51536981
47positive regulation of mRNA processing (GO:0050685)3.50610976
48regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.48012720
49positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.48012720
50positive regulation of mRNA 3-end processing (GO:0031442)3.45623612
51S-adenosylmethionine metabolic process (GO:0046500)3.42008585
52protein polyglutamylation (GO:0018095)3.41907311
53cell wall macromolecule metabolic process (GO:0044036)3.41557264
54detection of light stimulus involved in sensory perception (GO:0050962)3.36390164
55detection of light stimulus involved in visual perception (GO:0050908)3.36390164
56negative regulation of striated muscle cell apoptotic process (GO:0010664)3.35499561
57negative regulation of smooth muscle cell migration (GO:0014912)3.33355284
58notochord development (GO:0030903)3.32616558
59N-terminal protein amino acid acetylation (GO:0006474)3.28563434
60tryptophan metabolic process (GO:0006568)3.26927298
61lactate metabolic process (GO:0006089)3.24934433
62single strand break repair (GO:0000012)3.24538668
63cytoplasmic mRNA processing body assembly (GO:0033962)3.22102687
64DNA double-strand break processing (GO:0000729)3.21600650
65fucose catabolic process (GO:0019317)3.21540960
66L-fucose metabolic process (GO:0042354)3.21540960
67L-fucose catabolic process (GO:0042355)3.21540960
68macroautophagy (GO:0016236)3.19986817
69ventricular cardiac muscle cell development (GO:0055015)3.16099061
70negative regulation of mRNA processing (GO:0050686)3.14767484
71negative regulation of translation, ncRNA-mediated (GO:0040033)3.11795023
72regulation of translation, ncRNA-mediated (GO:0045974)3.11795023
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11795023
74T cell apoptotic process (GO:0070231)3.10997257
75regulation of DNA endoreduplication (GO:0032875)3.09638961
76phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.08834412
77heart valve morphogenesis (GO:0003179)3.05023423
78retinal cone cell development (GO:0046549)3.03783890
79negative regulation of epithelial to mesenchymal transition (GO:0010719)3.03348777
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.02623250
81negative regulation of Notch signaling pathway (GO:0045746)3.02612835
82regulation of cardiac muscle cell apoptotic process (GO:0010665)2.96741213
83somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94861202
84somatic hypermutation of immunoglobulin genes (GO:0016446)2.94861202
85kynurenine metabolic process (GO:0070189)2.92509994
86detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.91767512
87trabecula morphogenesis (GO:0061383)2.82728875
88lymphocyte apoptotic process (GO:0070227)2.82558016
89regulation of meiosis I (GO:0060631)2.82300228
90aromatic amino acid family catabolic process (GO:0009074)2.82239858
91negative regulation of mast cell activation (GO:0033004)2.81626705
92positive regulation of heart rate (GO:0010460)2.81337357
93peptidyl-cysteine modification (GO:0018198)2.81296668
94myotube differentiation (GO:0014902)2.79454446
95preassembly of GPI anchor in ER membrane (GO:0016254)2.78738223
96G-protein coupled receptor internalization (GO:0002031)2.78316825
97artery development (GO:0060840)2.78191124
98response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.76565677
99regulation of dendritic spine morphogenesis (GO:0061001)2.74908404
100C-terminal protein lipidation (GO:0006501)2.74148186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.17608354
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.13704991
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.13044013
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82613568
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66306367
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66209241
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47647331
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.45684344
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.43273275
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33790463
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.30808873
12GBX2_23144817_ChIP-Seq_PC3_Human2.27371786
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24318373
14EWS_26573619_Chip-Seq_HEK293_Human2.23363212
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.22207980
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11229057
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10506648
18ELK1_19687146_ChIP-ChIP_HELA_Human2.08901784
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.08858030
20FUS_26573619_Chip-Seq_HEK293_Human2.05468214
21TAF15_26573619_Chip-Seq_HEK293_Human1.96902052
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.95760551
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91321670
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90870180
25ER_23166858_ChIP-Seq_MCF-7_Human1.82586726
26ZNF274_21170338_ChIP-Seq_K562_Hela1.82149865
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78488685
28P300_19829295_ChIP-Seq_ESCs_Human1.76465887
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70753814
30VDR_22108803_ChIP-Seq_LS180_Human1.67973729
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63314979
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62947559
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57393643
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.56016319
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.53929307
36SMAD4_21799915_ChIP-Seq_A2780_Human1.52648217
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51712092
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49458559
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48187974
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46851126
41LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46178362
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.46169720
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45990451
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45990451
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45942549
46TP53_16413492_ChIP-PET_HCT116_Human1.44752710
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.44211290
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43757415
49AHR_22903824_ChIP-Seq_MCF-7_Human1.43498428
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43165918
51TCF4_22108803_ChIP-Seq_LS180_Human1.42467996
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39758952
53RNF2_27304074_Chip-Seq_NSC_Mouse1.37603818
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.35232663
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33767424
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32554085
57STAT3_23295773_ChIP-Seq_U87_Human1.30011770
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.28651245
59CJUN_26792858_Chip-Seq_BT549_Human1.28276211
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27864759
61RXR_22108803_ChIP-Seq_LS180_Human1.27237383
62FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.25855814
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25275350
64AR_25329375_ChIP-Seq_VCAP_Human1.24962329
65TP53_18474530_ChIP-ChIP_U2OS_Human1.24525276
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.23824396
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.23672234
68P53_22387025_ChIP-Seq_ESCs_Mouse1.21569855
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.20924577
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19840473
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19840473
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.19445158
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18732776
74SOX2_19829295_ChIP-Seq_ESCs_Human1.17124722
75NANOG_19829295_ChIP-Seq_ESCs_Human1.17124722
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15462425
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15145521
78BCAT_22108803_ChIP-Seq_LS180_Human1.14965459
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14091912
80FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13949492
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.12726320
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10642602
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10395990
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10238098
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09190440
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.07367259
87AR_21909140_ChIP-Seq_LNCAP_Human1.07038512
88P300_18555785_Chip-Seq_ESCs_Mouse1.06290872
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04535923
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03686667
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02888834
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02001368
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01599559
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01528009
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00382282
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99828929
97SOX9_26525672_Chip-Seq_HEART_Mouse0.98883036
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.98573121
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.98474956
100TBL1_22424771_ChIP-Seq_293T_Human0.98034329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.54251539
2MP0008058_abnormal_DNA_repair3.43221293
3MP0005423_abnormal_somatic_nervous3.34082584
4MP0002102_abnormal_ear_morphology2.94639901
5MP0008057_abnormal_DNA_replication2.73162799
6MP0005367_renal/urinary_system_phenotyp2.68201168
7MP0000516_abnormal_urinary_system2.68201168
8MP0002163_abnormal_gland_morphology2.34366239
9MP0008961_abnormal_basal_metabolism2.32631280
10MP0002822_catalepsy2.31196319
11MP0009384_cardiac_valve_regurgitation2.23458604
12MP0000569_abnormal_digit_pigmentation2.22450002
13MP0002127_abnormal_cardiovascular_syste2.21119079
14MP0005670_abnormal_white_adipose2.14768605
15MP0003315_abnormal_perineum_morphology2.13343382
16MP0002736_abnormal_nociception_after2.12977535
17MP0002653_abnormal_ependyma_morphology2.05654535
18MP0003880_abnormal_central_pattern2.00504073
19MP0008789_abnormal_olfactory_epithelium1.97315697
20MP0000613_abnormal_salivary_gland1.88136416
21MP0003755_abnormal_palate_morphology1.84891712
22MP0010094_abnormal_chromosome_stability1.80072132
23MP0005379_endocrine/exocrine_gland_phen1.77260730
24MP0000566_synostosis1.76311162
25MP0003950_abnormal_plasma_membrane1.71372048
26MP0008995_early_reproductive_senescence1.67244893
27MP0002938_white_spotting1.63162002
28MP0008875_abnormal_xenobiotic_pharmacok1.61998864
29MP0005394_taste/olfaction_phenotype1.61961852
30MP0005499_abnormal_olfactory_system1.61961852
31MP0001501_abnormal_sleep_pattern1.57811596
32MP0005083_abnormal_biliary_tract1.57188739
33MP0003786_premature_aging1.56765208
34MP0000427_abnormal_hair_cycle1.52974676
35MP0002233_abnormal_nose_morphology1.47536319
36MP0002751_abnormal_autonomic_nervous1.41087794
37MP0002234_abnormal_pharynx_morphology1.35558154
38MP0006138_congestive_heart_failure1.31935133
39MP0004133_heterotaxia1.31856963
40MP0003186_abnormal_redox_activity1.29675065
41MP0006292_abnormal_olfactory_placode1.27833694
42MP0003943_abnormal_hepatobiliary_system1.27374008
43MP0006276_abnormal_autonomic_nervous1.25898128
44MP0004043_abnormal_pH_regulation1.24941768
45MP0005551_abnormal_eye_electrophysiolog1.21263088
46MP0001293_anophthalmia1.16102311
47MP0004085_abnormal_heartbeat1.15776293
48MP0001529_abnormal_vocalization1.15068411
49MP0004264_abnormal_extraembryonic_tissu1.12446061
50MP0004019_abnormal_vitamin_homeostasis1.12381678
51MP0005646_abnormal_pituitary_gland1.11968866
52MP0002282_abnormal_trachea_morphology1.11718732
53MP0001486_abnormal_startle_reflex1.08751283
54MP0000538_abnormal_urinary_bladder1.08208501
55MP0003890_abnormal_embryonic-extraembry1.08182661
56MP0005266_abnormal_metabolism1.06338150
57MP0001968_abnormal_touch/_nociception1.05492179
58MP0002557_abnormal_social/conspecific_i1.05360006
59MP0000647_abnormal_sebaceous_gland1.05331270
60MP0008007_abnormal_cellular_replicative0.99585641
61MP0004215_abnormal_myocardial_fiber0.96180700
62MP0000653_abnormal_sex_gland0.94292621
63MP0009703_decreased_birth_body0.94128702
64MP0006072_abnormal_retinal_apoptosis0.93315864
65MP0004270_analgesia0.92688085
66MP0001119_abnormal_female_reproductive0.90290078
67MP0001984_abnormal_olfaction0.90170432
68MP0001873_stomach_inflammation0.89333996
69MP0002277_abnormal_respiratory_mucosa0.89151823
70MP0002108_abnormal_muscle_morphology0.87760519
71MP0005187_abnormal_penis_morphology0.87184650
72MP0001666_abnormal_nutrient_absorption0.86890859
73MP0002972_abnormal_cardiac_muscle0.86238056
74MP0005253_abnormal_eye_physiology0.86177956
75MP0003941_abnormal_skin_development0.85023184
76MP0001145_abnormal_male_reproductive0.84563652
77MP0003567_abnormal_fetal_cardiomyocyte0.82946259
78MP0001764_abnormal_homeostasis0.81057572
79MP0003221_abnormal_cardiomyocyte_apopto0.79413510
80MP0003011_delayed_dark_adaptation0.78935414
81MP0001853_heart_inflammation0.77695343
82MP0000750_abnormal_muscle_regeneration0.76660142
83MP0001929_abnormal_gametogenesis0.75837275
84MP0002697_abnormal_eye_size0.75558721
85MP0001485_abnormal_pinna_reflex0.75358776
86MP0002210_abnormal_sex_determination0.74833511
87MP0001286_abnormal_eye_development0.73249065
88MP0003718_maternal_effect0.72948362
89MP0000631_abnormal_neuroendocrine_gland0.70865179
90MP0000778_abnormal_nervous_system0.70170739
91MP0003077_abnormal_cell_cycle0.69252868
92MP0001188_hyperpigmentation0.69176580
93MP0000049_abnormal_middle_ear0.68533748
94MP0009745_abnormal_behavioral_response0.67075218
95MP0005376_homeostasis/metabolism_phenot0.66936471
96MP0005332_abnormal_amino_acid0.66740540
97MP0008873_increased_physiological_sensi0.66656132
98MP0009046_muscle_twitch0.64175091
99MP0001756_abnormal_urination0.61258400
100MP0003937_abnormal_limbs/digits/tail_de0.58894994

Predicted human phenotypes

RankGene SetZ-score
1Gaze-evoked nystagmus (HP:0000640)3.96085761
2Scanning speech (HP:0002168)3.70257010
3Abnormality of the preputium (HP:0100587)3.55176346
4Atonic seizures (HP:0010819)3.43919580
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.32195804
6Genetic anticipation (HP:0003743)3.26739116
7Anophthalmia (HP:0000528)3.25821441
8Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.18786253
9Severe visual impairment (HP:0001141)3.18419288
10Progressive cerebellar ataxia (HP:0002073)3.16996849
11Febrile seizures (HP:0002373)3.07538869
12Bifid tongue (HP:0010297)2.91380374
13Curly hair (HP:0002212)2.85367664
14Meckel diverticulum (HP:0002245)2.85280979
15Abnormality of macular pigmentation (HP:0008002)2.83157824
16Duplicated collecting system (HP:0000081)2.78840588
17Hyperglycinemia (HP:0002154)2.77526471
18Abnormality of the ileum (HP:0001549)2.69526831
19Abnormality of the pons (HP:0007361)2.65906289
20Stenosis of the external auditory canal (HP:0000402)2.65795181
21Hypothermia (HP:0002045)2.65142115
22Abnormality of the nasal septum (HP:0000419)2.64492127
23Occipital encephalocele (HP:0002085)2.60751966
24Median cleft lip (HP:0000161)2.60024542
25Wide intermamillary distance (HP:0006610)2.57242660
26Congenital, generalized hypertrichosis (HP:0004540)2.55756423
27Abnormality of the renal collecting system (HP:0004742)2.54502313
28Areflexia of lower limbs (HP:0002522)2.52681697
29Urinary bladder sphincter dysfunction (HP:0002839)2.51934326
30Abnormality of chromosome stability (HP:0003220)2.49551093
31Bony spicule pigmentary retinopathy (HP:0007737)2.48443781
32Triphalangeal thumb (HP:0001199)2.48141498
33Absent eyebrow (HP:0002223)2.46036010
34Ureteral duplication (HP:0000073)2.44919186
35Breast carcinoma (HP:0003002)2.41839360
36Hyperventilation (HP:0002883)2.40526953
37Small intestinal stenosis (HP:0012848)2.39895722
38Duodenal stenosis (HP:0100867)2.39895722
39Lissencephaly (HP:0001339)2.39668812
40Morphological abnormality of the middle ear (HP:0008609)2.39437816
41Severe Myopia (HP:0011003)2.39045223
42Bilateral microphthalmos (HP:0007633)2.38654347
43Dysmetric saccades (HP:0000641)2.36155159
44Dysdiadochokinesis (HP:0002075)2.35575244
45Depressed nasal tip (HP:0000437)2.30205889
46Sparse eyelashes (HP:0000653)2.29504398
47Clubbing of toes (HP:0100760)2.27969952
48Central scotoma (HP:0000603)2.25862320
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24146908
50True hermaphroditism (HP:0010459)2.19753331
51Agnosia (HP:0010524)2.18188152
52Stomach cancer (HP:0012126)2.17251108
53Chorioretinal atrophy (HP:0000533)2.16921972
54Prostate neoplasm (HP:0100787)2.16902613
55Truncal ataxia (HP:0002078)2.13514775
56Acute encephalopathy (HP:0006846)2.13429652
57Abnormality of the duodenum (HP:0002246)2.06729994
58Optic nerve hypoplasia (HP:0000609)2.05894344
59Aplasia/Hypoplasia of the sternum (HP:0006714)1.98519714
60Type II lissencephaly (HP:0007260)1.98382413
61Follicular hyperkeratosis (HP:0007502)1.97388828
62Abnormal rod and cone electroretinograms (HP:0008323)1.97379115
63Chromsome breakage (HP:0040012)1.95614209
64Astrocytoma (HP:0009592)1.95372032
65Abnormality of the astrocytes (HP:0100707)1.95372032
66Respiratory distress (HP:0002098)1.95011388
67Epileptic encephalopathy (HP:0200134)1.95004469
68Ependymoma (HP:0002888)1.94357945
69Colon cancer (HP:0003003)1.89975214
70Genital tract atresia (HP:0001827)1.89069057
71Acute myeloid leukemia (HP:0004808)1.85374228
72Impaired smooth pursuit (HP:0007772)1.85361298
73Vaginal atresia (HP:0000148)1.84255686
74Abnormality of serine family amino acid metabolism (HP:0010894)1.84215116
75Abnormality of glycine metabolism (HP:0010895)1.84215116
76Impaired vibratory sensation (HP:0002495)1.83501659
77Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83349120
78Absent eyelashes (HP:0000561)1.82385620
79Bicornuate uterus (HP:0000813)1.81347604
80Abnormality of DNA repair (HP:0003254)1.80626901
81Hypoplasia of the pons (HP:0012110)1.80402400
82Hyperglycinuria (HP:0003108)1.78606604
83Cupped ear (HP:0000378)1.77523323
84Acute necrotizing encephalopathy (HP:0006965)1.76347667
85Abnormality of the carotid arteries (HP:0005344)1.76197162
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75579727
87Medial flaring of the eyebrow (HP:0010747)1.75230357
88Meningocele (HP:0002435)1.75216124
89Absent radius (HP:0003974)1.74941101
90Pachygyria (HP:0001302)1.74525277
91Absence seizures (HP:0002121)1.74148619
92Abnormality of the axillary hair (HP:0100134)1.73264453
93Abnormality of secondary sexual hair (HP:0009888)1.73264453
94Septo-optic dysplasia (HP:0100842)1.70640283
95Renal hypoplasia (HP:0000089)1.70370302
96Abnormal lung lobation (HP:0002101)1.69326405
97Aplasia involving forearm bones (HP:0009822)1.68144844
98Absent forearm bone (HP:0003953)1.68144844
99Midline defect of the nose (HP:0004122)1.67084125
100Tetraparesis (HP:0002273)1.66612095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.31502474
2BRSK24.80880397
3WEE14.19496619
4STK38L3.52925849
5MKNK23.31985957
6GRK12.96944754
7FRK2.86450961
8AKT32.76770107
9BCR2.66631145
10MST42.62886068
11MAP3K122.35082807
12TNIK2.22948598
13LATS12.16170659
14MAP3K42.12825541
15BRSK12.08117833
16MKNK11.96377437
17CASK1.82299877
18PDK21.78005583
19TSSK61.71318295
20TRIM281.68227759
21PNCK1.63145150
22NUAK11.38274602
23TAOK11.34713444
24WNK31.32100441
25STK381.24865374
26STK161.16822881
27PAK31.03852811
28BUB11.01435812
29CSNK1G10.97949275
30TAOK30.95462413
31TAOK20.94583033
32CSNK1G30.92812494
33CDC70.88959865
34CAMK1G0.88240066
35PBK0.88191101
36CSNK1G20.84393587
37DYRK30.82144294
38CAMK1D0.78649126
39MAPK130.77774937
40MYLK0.73591857
41ADRBK20.72911443
42CSNK1A1L0.70143465
43STK390.68289287
44SIK30.67830402
45IKBKB0.67785957
46KSR10.67175300
47MELK0.66427058
48MAP2K70.65565875
49ERBB40.65496655
50PRKCE0.65256192
51VRK10.62983407
52VRK20.62877090
53ZAK0.62432601
54RIPK10.61463435
55MAP2K10.60965052
56MAP3K30.60197421
57OXSR10.58649750
58PRKCG0.53980165
59FGR0.53277850
60IRAK20.50290766
61DYRK20.49762188
62LATS20.49581424
63ERBB30.46160340
64PHKG10.45815578
65PHKG20.45815578
66MAP3K50.43454834
67ABL20.43403620
68EPHA40.41206949
69BMPR1B0.40428783
70FGFR10.40353587
71MARK10.39921491
72CSNK1D0.38836829
73YES10.37427468
74MET0.37415694
75PRKCI0.37319599
76MINK10.35158330
77ACVR1B0.34426497
78FER0.32332627
79EGFR0.31454922
80PTK2B0.30878130
81PKN20.28877822
82CSNK1E0.28202909
83CHEK10.27277273
84PLK10.27151915
85ATM0.26914635
86NEK90.26463069
87TNK20.25533072
88WNK40.25427963
89EIF2AK30.24778488
90MAPK70.24164664
91PIK3CG0.22866355
92PLK30.22248735
93NTRK20.21924809
94PRKACB0.21460773
95CHEK20.21233426
96CSNK2A10.20208602
97ITK0.19936156
98EIF2AK20.18488774
99PLK40.18340076
100PLK20.17216064

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.94919396
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.57468965
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.31252485
4Selenocompound metabolism_Homo sapiens_hsa004503.23221909
5Fanconi anemia pathway_Homo sapiens_hsa034602.92175450
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.77822577
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.72728069
8Non-homologous end-joining_Homo sapiens_hsa034502.48840983
9Caffeine metabolism_Homo sapiens_hsa002322.18937561
10Sulfur metabolism_Homo sapiens_hsa009202.03376322
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96654119
12RNA polymerase_Homo sapiens_hsa030201.92123136
13Butanoate metabolism_Homo sapiens_hsa006501.85900337
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81609930
15Nicotine addiction_Homo sapiens_hsa050331.79858122
16Phototransduction_Homo sapiens_hsa047441.71531757
17Mismatch repair_Homo sapiens_hsa034301.67300209
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64678948
19Protein export_Homo sapiens_hsa030601.57739192
20Olfactory transduction_Homo sapiens_hsa047401.52551915
21Tryptophan metabolism_Homo sapiens_hsa003801.52387729
22Homologous recombination_Homo sapiens_hsa034401.51739409
23Taste transduction_Homo sapiens_hsa047421.50971143
24Basal transcription factors_Homo sapiens_hsa030221.43491736
25One carbon pool by folate_Homo sapiens_hsa006701.41384826
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41301601
27RNA degradation_Homo sapiens_hsa030181.33981608
28Vitamin B6 metabolism_Homo sapiens_hsa007501.28355451
29Sphingolipid metabolism_Homo sapiens_hsa006001.13087542
30DNA replication_Homo sapiens_hsa030301.10773102
31Base excision repair_Homo sapiens_hsa034101.10320472
32Propanoate metabolism_Homo sapiens_hsa006401.07923753
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07661336
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05536477
35Circadian rhythm_Homo sapiens_hsa047101.04694512
36Sulfur relay system_Homo sapiens_hsa041221.02933676
37Dorso-ventral axis formation_Homo sapiens_hsa043201.00202347
38Oxidative phosphorylation_Homo sapiens_hsa001900.99442371
39Proteasome_Homo sapiens_hsa030500.99303518
40Parkinsons disease_Homo sapiens_hsa050120.93475709
41beta-Alanine metabolism_Homo sapiens_hsa004100.90819484
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90592403
43Tight junction_Homo sapiens_hsa045300.90514734
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89046681
45Nucleotide excision repair_Homo sapiens_hsa034200.87459607
46Cocaine addiction_Homo sapiens_hsa050300.85916766
47p53 signaling pathway_Homo sapiens_hsa041150.83980477
48Nitrogen metabolism_Homo sapiens_hsa009100.83760509
49Huntingtons disease_Homo sapiens_hsa050160.83642428
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80873181
51Dopaminergic synapse_Homo sapiens_hsa047280.80502566
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.79577693
53Arginine and proline metabolism_Homo sapiens_hsa003300.72098464
54GABAergic synapse_Homo sapiens_hsa047270.67702967
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67452643
56Ether lipid metabolism_Homo sapiens_hsa005650.65470409
57Pyrimidine metabolism_Homo sapiens_hsa002400.65039346
58Linoleic acid metabolism_Homo sapiens_hsa005910.64454487
59Amphetamine addiction_Homo sapiens_hsa050310.61815528
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57537535
61TGF-beta signaling pathway_Homo sapiens_hsa043500.55965750
62Mineral absorption_Homo sapiens_hsa049780.55205039
63Lysine degradation_Homo sapiens_hsa003100.54955763
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52208120
65Purine metabolism_Homo sapiens_hsa002300.51035462
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50800308
67Fatty acid degradation_Homo sapiens_hsa000710.50567744
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49632807
69Circadian entrainment_Homo sapiens_hsa047130.48127071
70Calcium signaling pathway_Homo sapiens_hsa040200.46629505
71Chemical carcinogenesis_Homo sapiens_hsa052040.46525729
72Fat digestion and absorption_Homo sapiens_hsa049750.46151161
73RNA transport_Homo sapiens_hsa030130.45578666
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44107160
75Pyruvate metabolism_Homo sapiens_hsa006200.43964046
76Metabolic pathways_Homo sapiens_hsa011000.43089797
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43005738
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.42891806
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42704760
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40188804
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40069796
82Inositol phosphate metabolism_Homo sapiens_hsa005620.38884229
83Axon guidance_Homo sapiens_hsa043600.38217199
84mRNA surveillance pathway_Homo sapiens_hsa030150.36032339
85Cell cycle_Homo sapiens_hsa041100.35664093
86Glutamatergic synapse_Homo sapiens_hsa047240.35166981
87ErbB signaling pathway_Homo sapiens_hsa040120.35089645
88Retinol metabolism_Homo sapiens_hsa008300.34516086
89Glutathione metabolism_Homo sapiens_hsa004800.32635728
90Melanoma_Homo sapiens_hsa052180.32295586
91Regulation of autophagy_Homo sapiens_hsa041400.31225864
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29946322
93Glycerolipid metabolism_Homo sapiens_hsa005610.29928268
94Prostate cancer_Homo sapiens_hsa052150.29904652
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29256600
96Estrogen signaling pathway_Homo sapiens_hsa049150.29095490
97Histidine metabolism_Homo sapiens_hsa003400.28288881
98Fatty acid metabolism_Homo sapiens_hsa012120.28236182
99Hepatitis C_Homo sapiens_hsa051600.26852637
100Hippo signaling pathway_Homo sapiens_hsa043900.26686730

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