HMGB1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.33709658
2DNA deamination (GO:0045006)5.46888347
3response to pheromone (GO:0019236)4.43985527
4detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.33517934
5L-fucose catabolic process (GO:0042355)3.94512535
6fucose catabolic process (GO:0019317)3.94512535
7L-fucose metabolic process (GO:0042354)3.94512535
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88916616
9synaptic transmission, cholinergic (GO:0007271)3.75105103
10protein complex biogenesis (GO:0070271)3.53831345
11water-soluble vitamin biosynthetic process (GO:0042364)3.53535135
12platelet dense granule organization (GO:0060155)3.50140634
13preassembly of GPI anchor in ER membrane (GO:0016254)3.49174286
14piRNA metabolic process (GO:0034587)3.38543829
15cytidine deamination (GO:0009972)3.38020188
16cytidine metabolic process (GO:0046087)3.38020188
17cytidine catabolic process (GO:0006216)3.38020188
18protein-cofactor linkage (GO:0018065)3.35650476
19mitochondrial respiratory chain complex assembly (GO:0033108)3.34695318
20negative regulation of mast cell activation (GO:0033004)3.33986971
21indole-containing compound catabolic process (GO:0042436)3.32576283
22indolalkylamine catabolic process (GO:0046218)3.32576283
23tryptophan catabolic process (GO:0006569)3.32576283
24cellular ketone body metabolic process (GO:0046950)3.32434858
25indolalkylamine metabolic process (GO:0006586)3.29324735
26ubiquinone biosynthetic process (GO:0006744)3.28761390
27negative regulation of telomere maintenance (GO:0032205)3.28750154
28kynurenine metabolic process (GO:0070189)3.26738693
29adaptation of signaling pathway (GO:0023058)3.24743713
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24454978
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.23297652
32NADH dehydrogenase complex assembly (GO:0010257)3.23297652
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23297652
34ATP synthesis coupled proton transport (GO:0015986)3.15529598
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15529598
36detection of light stimulus involved in sensory perception (GO:0050962)3.12721582
37detection of light stimulus involved in visual perception (GO:0050908)3.12721582
38epithelial cilium movement (GO:0003351)3.12123089
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11484594
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11484594
41axoneme assembly (GO:0035082)3.08378405
42ubiquinone metabolic process (GO:0006743)3.07542677
43respiratory chain complex IV assembly (GO:0008535)3.05335841
44protein neddylation (GO:0045116)3.03253294
45neural tube formation (GO:0001841)3.01196680
46positive regulation of fatty acid transport (GO:2000193)3.00050485
47ketone body metabolic process (GO:1902224)2.98963882
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92607548
49behavioral response to ethanol (GO:0048149)2.91394320
50cornea development in camera-type eye (GO:0061303)2.90868657
51cytochrome complex assembly (GO:0017004)2.89457428
52protein polyglutamylation (GO:0018095)2.89454801
53pyrimidine ribonucleoside catabolic process (GO:0046133)2.88893926
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85925219
55tryptophan metabolic process (GO:0006568)2.85217121
56positive regulation of prostaglandin secretion (GO:0032308)2.84708603
57regulation of action potential (GO:0098900)2.84639207
58establishment of protein localization to mitochondrial membrane (GO:0090151)2.81314078
59gamma-aminobutyric acid transport (GO:0015812)2.78876333
60cellular biogenic amine catabolic process (GO:0042402)2.78402477
61amine catabolic process (GO:0009310)2.78402477
62regulation of cilium movement (GO:0003352)2.77992669
63GPI anchor metabolic process (GO:0006505)2.73727161
64mannosylation (GO:0097502)2.73150453
65nonmotile primary cilium assembly (GO:0035058)2.71746689
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67969895
67regulation of glucokinase activity (GO:0033131)2.65398891
68regulation of hexokinase activity (GO:1903299)2.65398891
69neuronal action potential (GO:0019228)2.63105486
70quinone biosynthetic process (GO:1901663)2.62963533
71negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60583984
72pyrimidine nucleobase catabolic process (GO:0006208)2.59949935
73phosphatidylinositol acyl-chain remodeling (GO:0036149)2.59909654
74kidney morphogenesis (GO:0060993)2.59806785
75sulfation (GO:0051923)2.58523665
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57963885
77negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57649662
78positive regulation of icosanoid secretion (GO:0032305)2.57454606
79neuron fate determination (GO:0048664)2.56864476
80rRNA catabolic process (GO:0016075)2.55944257
81S-adenosylmethionine metabolic process (GO:0046500)2.55944164
82detection of mechanical stimulus involved in sensory perception (GO:0050974)2.55753043
83indole-containing compound metabolic process (GO:0042430)2.53959265
84male meiosis I (GO:0007141)2.53732690
85protein localization to cilium (GO:0061512)2.52923154
86multicellular organism reproduction (GO:0032504)2.51699192
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51035988
88cilium movement (GO:0003341)2.50958823
89DNA demethylation (GO:0080111)2.50729013
90transmission of nerve impulse (GO:0019226)2.50576907
91regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50364910
92photoreceptor cell maintenance (GO:0045494)2.49639180
93reflex (GO:0060004)2.47868976
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47315302
95rhodopsin mediated signaling pathway (GO:0016056)2.46923948
96endoderm formation (GO:0001706)2.45078522
97metallo-sulfur cluster assembly (GO:0031163)2.44616079
98iron-sulfur cluster assembly (GO:0016226)2.44616079
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.44464461
100nucleobase catabolic process (GO:0046113)2.41943810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.03862650
2VDR_22108803_ChIP-Seq_LS180_Human3.74318672
3EZH2_22144423_ChIP-Seq_EOC_Human3.50514141
4IGF1R_20145208_ChIP-Seq_DFB_Human2.56760197
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48674740
6GBX2_23144817_ChIP-Seq_PC3_Human2.35514991
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34819231
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33929096
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.12002255
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.09640183
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03400940
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03168051
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95295583
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91779979
15EWS_26573619_Chip-Seq_HEK293_Human1.84904680
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83969007
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80316444
18IRF1_19129219_ChIP-ChIP_H3396_Human1.80253537
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79029211
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78486751
21ER_23166858_ChIP-Seq_MCF-7_Human1.77526161
22P300_19829295_ChIP-Seq_ESCs_Human1.77056966
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76186792
24FUS_26573619_Chip-Seq_HEK293_Human1.76119496
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69999450
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.67764392
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.66572156
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61829425
29TP53_22573176_ChIP-Seq_HFKS_Human1.61451244
30TAF15_26573619_Chip-Seq_HEK293_Human1.59234048
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55459919
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53331455
33BCAT_22108803_ChIP-Seq_LS180_Human1.52316885
34REST_21632747_ChIP-Seq_MESCs_Mouse1.51847557
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51294513
36CBP_20019798_ChIP-Seq_JUKART_Human1.51294513
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44083696
38MYC_18940864_ChIP-ChIP_HL60_Human1.42888111
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.41989006
40NANOG_19829295_ChIP-Seq_ESCs_Human1.41853108
41SOX2_19829295_ChIP-Seq_ESCs_Human1.41853108
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40530562
43AR_25329375_ChIP-Seq_VCAP_Human1.39240030
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37396446
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.37396446
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.35053820
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35050612
48NCOR_22424771_ChIP-Seq_293T_Human1.32202231
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31496789
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30092499
51RNF2_27304074_Chip-Seq_NSC_Mouse1.27391222
52AR_20517297_ChIP-Seq_VCAP_Human1.26446851
53VDR_23849224_ChIP-Seq_CD4+_Human1.24653615
54TCF4_22108803_ChIP-Seq_LS180_Human1.24362410
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23849294
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23054893
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23054893
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22342889
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22288053
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22259355
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21970379
62ELK1_19687146_ChIP-ChIP_HELA_Human1.21785311
63TCF4_23295773_ChIP-Seq_U87_Human1.20528836
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20052948
65SMAD4_21799915_ChIP-Seq_A2780_Human1.18797436
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18784383
67STAT3_23295773_ChIP-Seq_U87_Human1.18567371
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18420715
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.17884815
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.17690290
71HTT_18923047_ChIP-ChIP_STHdh_Human1.17414155
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16901442
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16514631
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.16215858
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15181022
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14771687
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.12958780
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.12316434
79RUNX2_22187159_ChIP-Seq_PCA_Human1.12300561
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.11253743
81NANOG_20526341_ChIP-Seq_ESCs_Human1.10828947
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10445489
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09435540
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08692193
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.08437263
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08181873
87HOXB7_26014856_ChIP-Seq_BT474_Human1.08164750
88MYC_19829295_ChIP-Seq_ESCs_Human1.06463969
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.05416223
90TAF2_19829295_ChIP-Seq_ESCs_Human1.04576315
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.03762689
92FOXH1_21741376_ChIP-Seq_EPCs_Human1.03417807
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03379704
94ERA_21632823_ChIP-Seq_H3396_Human1.00622492
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99639891
96EZH2_27304074_Chip-Seq_ESCs_Mouse0.99314719
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98767665
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98411460
99ETS1_20019798_ChIP-Seq_JURKAT_Human0.97842466
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97659043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.23562648
2MP0006292_abnormal_olfactory_placode2.76669574
3MP0008877_abnormal_DNA_methylation2.75972467
4MP0001968_abnormal_touch/_nociception2.66810116
5MP0002876_abnormal_thyroid_physiology2.49135106
6MP0003195_calcinosis2.47288943
7MP0005551_abnormal_eye_electrophysiolog2.42394515
8MP0003880_abnormal_central_pattern2.28217657
9MP0006072_abnormal_retinal_apoptosis2.24603050
10MP0005645_abnormal_hypothalamus_physiol2.22281770
11MP0003011_delayed_dark_adaptation2.17748893
12MP0002837_dystrophic_cardiac_calcinosis2.14538851
13MP0004885_abnormal_endolymph2.11767344
14MP0005646_abnormal_pituitary_gland2.11372394
15MP0008872_abnormal_physiological_respon2.08457610
16MP0001986_abnormal_taste_sensitivity2.08152320
17MP0003646_muscle_fatigue2.03172605
18MP0008875_abnormal_xenobiotic_pharmacok1.99487536
19MP0002736_abnormal_nociception_after1.94059983
20MP0009745_abnormal_behavioral_response1.92857293
21MP0003787_abnormal_imprinting1.90243185
22MP0009046_muscle_twitch1.81999650
23MP0004142_abnormal_muscle_tone1.78496548
24MP0002272_abnormal_nervous_system1.74297595
25MP0004147_increased_porphyrin_level1.72474217
26MP0005253_abnormal_eye_physiology1.67587733
27MP0004133_heterotaxia1.57519125
28MP0002638_abnormal_pupillary_reflex1.53545375
29MP0008789_abnormal_olfactory_epithelium1.48552147
30MP0001501_abnormal_sleep_pattern1.48168036
31MP0002234_abnormal_pharynx_morphology1.47308713
32MP0005671_abnormal_response_to1.46476365
33MP0004043_abnormal_pH_regulation1.44608037
34MP0000631_abnormal_neuroendocrine_gland1.41587018
35MP0006276_abnormal_autonomic_nervous1.40908860
36MP0000372_irregular_coat_pigmentation1.38829954
37MP0010386_abnormal_urinary_bladder1.38592190
38MP0001919_abnormal_reproductive_system1.36687956
39MP0002938_white_spotting1.36256653
40MP0005389_reproductive_system_phenotype1.31300305
41MP0002163_abnormal_gland_morphology1.25571407
42MP0001984_abnormal_olfaction1.24394700
43MP0004145_abnormal_muscle_electrophysio1.23255748
44MP0001486_abnormal_startle_reflex1.20643707
45MP0002557_abnormal_social/conspecific_i1.19758794
46MP0001905_abnormal_dopamine_level1.19504387
47MP0008995_early_reproductive_senescence1.18524096
48MP0000427_abnormal_hair_cycle1.18448373
49MP0005174_abnormal_tail_pigmentation1.17237466
50MP0001529_abnormal_vocalization1.14347713
51MP0003136_yellow_coat_color1.13432588
52MP0002909_abnormal_adrenal_gland1.12256218
53MP0002095_abnormal_skin_pigmentation1.12062165
54MP0002064_seizures1.10717852
55MP0005379_endocrine/exocrine_gland_phen1.10377830
56MP0000569_abnormal_digit_pigmentation1.10335742
57MP0002572_abnormal_emotion/affect_behav1.09419471
58MP0002735_abnormal_chemical_nociception1.09058478
59MP0004742_abnormal_vestibular_system1.08334262
60MP0001485_abnormal_pinna_reflex1.08014590
61MP0002653_abnormal_ependyma_morphology1.06652012
62MP0001970_abnormal_pain_threshold1.06142502
63MP0009379_abnormal_foot_pigmentation1.05131034
64MP0005084_abnormal_gallbladder_morpholo1.04945874
65MP0005394_taste/olfaction_phenotype1.03872775
66MP0005499_abnormal_olfactory_system1.03872775
67MP0002733_abnormal_thermal_nociception1.03609011
68MP0002277_abnormal_respiratory_mucosa1.02792335
69MP0002184_abnormal_innervation1.01883583
70MP0008058_abnormal_DNA_repair1.01707458
71MP0002138_abnormal_hepatobiliary_system1.00564427
72MP0003635_abnormal_synaptic_transmissio1.00325949
73MP0005195_abnormal_posterior_eye0.98478205
74MP0008775_abnormal_heart_ventricle0.97044954
75MP0005167_abnormal_blood-brain_barrier0.96812295
76MP0005410_abnormal_fertilization0.95389649
77MP0005075_abnormal_melanosome_morpholog0.95327728
78MP0000026_abnormal_inner_ear0.95229960
79MP0000230_abnormal_systemic_arterial0.94929324
80MP0002063_abnormal_learning/memory/cond0.93566976
81MP0005423_abnormal_somatic_nervous0.93048630
82MP0004924_abnormal_behavior0.91639258
83MP0005386_behavior/neurological_phenoty0.91639258
84MP0002752_abnormal_somatic_nervous0.90886236
85MP0002160_abnormal_reproductive_system0.90260238
86MP0009764_decreased_sensitivity_to0.90252197
87MP0002751_abnormal_autonomic_nervous0.86995640
88MP0002067_abnormal_sensory_capabilities0.85984218
89MP0000049_abnormal_middle_ear0.85822209
90MP0001963_abnormal_hearing_physiology0.84950280
91MP0003137_abnormal_impulse_conducting0.83312722
92MP0000778_abnormal_nervous_system0.82684697
93MP0003879_abnormal_hair_cell0.81760164
94MP0001324_abnormal_eye_pigmentation0.80286927
95MP0005332_abnormal_amino_acid0.80160663
96MP0002229_neurodegeneration0.78534887
97MP0003252_abnormal_bile_duct0.76497650
98MP0005377_hearing/vestibular/ear_phenot0.76304673
99MP0003878_abnormal_ear_physiology0.76304673
100MP0002693_abnormal_pancreas_physiology0.76176483

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.44277506
2Pancreatic fibrosis (HP:0100732)4.02291988
3True hermaphroditism (HP:0010459)4.00429736
4Abnormality of midbrain morphology (HP:0002418)3.83093344
5Molar tooth sign on MRI (HP:0002419)3.83093344
6Nephronophthisis (HP:0000090)3.38729259
7Congenital stationary night blindness (HP:0007642)3.34104242
8Pendular nystagmus (HP:0012043)3.17954906
9Abolished electroretinogram (ERG) (HP:0000550)3.10343283
10Abnormality of the renal cortex (HP:0011035)3.08216888
11Medial flaring of the eyebrow (HP:0010747)2.99044135
12Abnormality of the renal medulla (HP:0100957)2.95146962
13Type II lissencephaly (HP:0007260)2.91679295
14Cystic liver disease (HP:0006706)2.89688412
15Polydipsia (HP:0001959)2.83633257
16Abnormal drinking behavior (HP:0030082)2.83633257
17Acute necrotizing encephalopathy (HP:0006965)2.83483737
18Chronic hepatic failure (HP:0100626)2.78690205
19Abnormal rod and cone electroretinograms (HP:0008323)2.75461946
20Attenuation of retinal blood vessels (HP:0007843)2.73491288
21Tubular atrophy (HP:0000092)2.72642680
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60512523
23Mitochondrial inheritance (HP:0001427)2.58073400
24Acute encephalopathy (HP:0006846)2.55352038
25Increased corneal curvature (HP:0100692)2.43402327
26Keratoconus (HP:0000563)2.43402327
27Progressive macrocephaly (HP:0004481)2.42181024
28Abnormal mitochondria in muscle tissue (HP:0008316)2.41561527
29Sclerocornea (HP:0000647)2.41288494
30Thyroid-stimulating hormone excess (HP:0002925)2.37018764
31Increased CSF lactate (HP:0002490)2.36049127
32Renal cortical cysts (HP:0000803)2.35888576
33Gait imbalance (HP:0002141)2.33367259
34Hyperventilation (HP:0002883)2.33127868
35Decreased central vision (HP:0007663)2.32457092
36Nephrogenic diabetes insipidus (HP:0009806)2.31663097
37Polyuria (HP:0000103)2.29865087
38Lissencephaly (HP:0001339)2.28341560
39Congenital, generalized hypertrichosis (HP:0004540)2.26053868
40Large for gestational age (HP:0001520)2.24242779
41Congenital primary aphakia (HP:0007707)2.23099804
42Hepatocellular necrosis (HP:0001404)2.19277085
43Anencephaly (HP:0002323)2.17548043
44Methylmalonic acidemia (HP:0002912)2.17476070
45Inability to walk (HP:0002540)2.17385239
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.16172722
47Bile duct proliferation (HP:0001408)2.14661575
48Abnormal biliary tract physiology (HP:0012439)2.14661575
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14363432
50Hyperalaninemia (HP:0003348)2.13605112
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13605112
52Abnormality of alanine metabolism (HP:0010916)2.13605112
53Optic disc pallor (HP:0000543)2.12301368
543-Methylglutaconic aciduria (HP:0003535)2.10636805
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.08013462
56Colon cancer (HP:0003003)2.07393495
57Severe muscular hypotonia (HP:0006829)2.05634602
58Progressive inability to walk (HP:0002505)2.03262071
59Male pseudohermaphroditism (HP:0000037)2.02855512
60Hepatic necrosis (HP:0002605)2.02574044
61Gaze-evoked nystagmus (HP:0000640)2.02049668
62IgG deficiency (HP:0004315)2.01878684
63Congenital hepatic fibrosis (HP:0002612)2.01348987
64Lipid accumulation in hepatocytes (HP:0006561)2.01342977
65Methylmalonic aciduria (HP:0012120)1.99558956
66Bony spicule pigmentary retinopathy (HP:0007737)1.99187120
67Concave nail (HP:0001598)1.99004642
68Constricted visual fields (HP:0001133)1.98901167
69Asplenia (HP:0001746)1.92914666
70Chorioretinal atrophy (HP:0000533)1.90239066
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89992868
72Abnormal respiratory epithelium morphology (HP:0012253)1.89810789
73Abnormal respiratory motile cilium morphology (HP:0005938)1.89810789
74Hemiparesis (HP:0001269)1.89265349
75Optic nerve hypoplasia (HP:0000609)1.88989871
76Progressive cerebellar ataxia (HP:0002073)1.88664293
77Furrowed tongue (HP:0000221)1.88535886
78Hypoalbuminemia (HP:0003073)1.88392011
79Abnormal albumin level (HP:0012116)1.88392011
80Broad-based gait (HP:0002136)1.88009103
81Aplasia/hypoplasia of the uterus (HP:0008684)1.87009629
82Genital tract atresia (HP:0001827)1.86605161
83Vaginal atresia (HP:0000148)1.86407992
84Cerebellar dysplasia (HP:0007033)1.86390609
85Increased serum lactate (HP:0002151)1.86215038
86Occipital encephalocele (HP:0002085)1.85559519
87Decreased circulating renin level (HP:0003351)1.84531571
88Abnormal urine output (HP:0012590)1.84006121
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.81097538
90Absent/shortened dynein arms (HP:0200106)1.81097538
91Intestinal atresia (HP:0011100)1.80747942
92Hypothermia (HP:0002045)1.79858485
93Agitation (HP:0000713)1.79037208
94Hypomagnesemia (HP:0002917)1.78803055
95Abnormality of the pons (HP:0007361)1.78480498
96Hyperglycinemia (HP:0002154)1.78022841
97Hypoproteinemia (HP:0003075)1.78018186
98Focal motor seizures (HP:0011153)1.76473610
99Postaxial foot polydactyly (HP:0001830)1.76096363
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.74141300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.25978290
2ADRBK23.98845835
3WNK43.07994143
4TLK12.65639980
5ZAK2.59414947
6MAP4K22.58120031
7TXK2.53260538
8GRK12.51222562
9WNK32.42142450
10BMPR1B2.38441890
11PINK12.26578018
12NUAK12.04609849
13TAOK32.03785305
14MAPK131.97568565
15STK391.95491591
16OXSR11.87305475
17ACVR1B1.70976175
18MAP3K41.68713389
19INSRR1.64985775
20BCKDK1.34486800
21DYRK21.34336524
22VRK21.31245211
23MAP2K71.30617828
24ADRBK11.19620983
25MUSK1.18142271
26TRIM281.15607262
27CASK1.14048860
28MST41.13630783
29TIE11.12597082
30VRK11.08222923
31CSNK1G31.05955127
32CSNK1G21.03503595
33CAMKK21.03405636
34PAK31.03228618
35PRKCG1.02903606
36PLK20.98585160
37DAPK20.98535246
38MARK10.96126225
39BCR0.95055452
40NTRK20.95030559
41CSNK1G10.94478724
42PRKCE0.93551435
43MKNK20.91510271
44CDK190.91478748
45TEC0.87949408
46PHKG20.84705252
47PHKG10.84705252
48PIK3CA0.81802755
49CSNK1A1L0.80989729
50ITK0.79648373
51KDR0.77503383
52EIF2AK30.75540758
53RPS6KA50.75081674
54PRKCQ0.72422266
55PRKCI0.72264318
56NTRK30.70685803
57TGFBR10.68364536
58MAPKAPK30.66908287
59TNIK0.65736355
60IKBKB0.65551148
61PLK30.64524960
62PLK40.62419230
63STK160.60041523
64CAMK2A0.55805937
65MAP2K60.54923596
66LIMK10.54611947
67KIT0.54409575
68MAPKAPK50.52327146
69CSNK1A10.52049103
70STK110.51115873
71MAPK150.51009431
72MAP3K120.50522898
73PRKACA0.50297649
74WNK10.49924271
75GRK70.49561468
76EPHA40.47876491
77SYK0.47251818
78PTK2B0.46964240
79TNK20.46663902
80MARK30.45456508
81CAMK10.43829142
82PNCK0.40846687
83PRKCA0.39997484
84FLT30.39325279
85CSNK1D0.39018226
86CDK30.38648876
87STK38L0.37509689
88PKN10.37444858
89MAP2K20.36552406
90DYRK1A0.36143515
91RPS6KA40.34634953
92IGF1R0.34135458
93OBSCN0.33340406
94CHUK0.33082042
95MINK10.32734803
96FGFR20.31698764
97MKNK10.31656486
98ERBB30.31514184
99FES0.30548926
100PRKCZ0.29972216

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.94471545
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68985406
3Phototransduction_Homo sapiens_hsa047442.64428114
4Linoleic acid metabolism_Homo sapiens_hsa005912.49274283
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40310227
6Protein export_Homo sapiens_hsa030602.37029223
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32831904
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23640706
9Parkinsons disease_Homo sapiens_hsa050122.20799579
10Nitrogen metabolism_Homo sapiens_hsa009102.16769721
11Butanoate metabolism_Homo sapiens_hsa006502.07722574
12Homologous recombination_Homo sapiens_hsa034402.02081146
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90446603
14Selenocompound metabolism_Homo sapiens_hsa004501.89751620
15Nicotine addiction_Homo sapiens_hsa050331.85408012
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.85308487
17RNA polymerase_Homo sapiens_hsa030201.79049839
18Ether lipid metabolism_Homo sapiens_hsa005651.71462322
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68486346
20Fanconi anemia pathway_Homo sapiens_hsa034601.56453215
21Primary immunodeficiency_Homo sapiens_hsa053401.55922810
22Proteasome_Homo sapiens_hsa030501.54779601
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.54742609
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48333069
25Alzheimers disease_Homo sapiens_hsa050101.44975205
26Tryptophan metabolism_Homo sapiens_hsa003801.44282736
27Olfactory transduction_Homo sapiens_hsa047401.41870388
28Caffeine metabolism_Homo sapiens_hsa002321.41609331
29Basal transcription factors_Homo sapiens_hsa030221.40541582
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40206923
31Huntingtons disease_Homo sapiens_hsa050161.39622219
32Cardiac muscle contraction_Homo sapiens_hsa042601.38225901
33Peroxisome_Homo sapiens_hsa041461.31938729
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.28417451
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27516513
36One carbon pool by folate_Homo sapiens_hsa006701.24717027
37Ribosome_Homo sapiens_hsa030101.22526334
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21467762
39RNA degradation_Homo sapiens_hsa030181.21370566
40Asthma_Homo sapiens_hsa053101.19281693
41Morphine addiction_Homo sapiens_hsa050321.14792255
42Propanoate metabolism_Homo sapiens_hsa006401.12662692
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.11918952
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11306517
45Collecting duct acid secretion_Homo sapiens_hsa049661.10140213
46Chemical carcinogenesis_Homo sapiens_hsa052041.10058420
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10001750
48Arachidonic acid metabolism_Homo sapiens_hsa005901.09155469
49Retinol metabolism_Homo sapiens_hsa008301.08240299
50Taste transduction_Homo sapiens_hsa047421.01471195
51Type I diabetes mellitus_Homo sapiens_hsa049401.01295585
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96031518
53Regulation of autophagy_Homo sapiens_hsa041400.95803176
54Autoimmune thyroid disease_Homo sapiens_hsa053200.95277316
55Allograft rejection_Homo sapiens_hsa053300.91499920
56Circadian entrainment_Homo sapiens_hsa047130.87125592
57Fat digestion and absorption_Homo sapiens_hsa049750.86705044
58GABAergic synapse_Homo sapiens_hsa047270.82311798
59Graft-versus-host disease_Homo sapiens_hsa053320.81992119
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81881204
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81841134
62Insulin secretion_Homo sapiens_hsa049110.80112463
63Sulfur relay system_Homo sapiens_hsa041220.79068999
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79064310
65Glutamatergic synapse_Homo sapiens_hsa047240.78071896
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73807670
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73758929
68ABC transporters_Homo sapiens_hsa020100.71598151
69Serotonergic synapse_Homo sapiens_hsa047260.68181527
70Purine metabolism_Homo sapiens_hsa002300.66829022
71Metabolic pathways_Homo sapiens_hsa011000.65302844
72Rheumatoid arthritis_Homo sapiens_hsa053230.64617008
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63916436
74Steroid biosynthesis_Homo sapiens_hsa001000.62782238
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59831864
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59461498
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58456383
78Pyrimidine metabolism_Homo sapiens_hsa002400.57841232
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56929866
80Salivary secretion_Homo sapiens_hsa049700.56860096
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56842100
82Ovarian steroidogenesis_Homo sapiens_hsa049130.56760079
83beta-Alanine metabolism_Homo sapiens_hsa004100.55197778
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49308604
85Nucleotide excision repair_Homo sapiens_hsa034200.48234207
86Sulfur metabolism_Homo sapiens_hsa009200.48188721
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45415032
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45294051
89Dopaminergic synapse_Homo sapiens_hsa047280.44091784
90Glycerolipid metabolism_Homo sapiens_hsa005610.41669815
91Hematopoietic cell lineage_Homo sapiens_hsa046400.41592528
92Calcium signaling pathway_Homo sapiens_hsa040200.40467506
93Amphetamine addiction_Homo sapiens_hsa050310.40115969
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39176475
95Fatty acid degradation_Homo sapiens_hsa000710.39162725
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.38360055
97Antigen processing and presentation_Homo sapiens_hsa046120.32494894
98Non-homologous end-joining_Homo sapiens_hsa034500.31319160
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27398786
100Fatty acid metabolism_Homo sapiens_hsa012120.26984354

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