HMGB1P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)5.90723074
2ATP synthesis coupled proton transport (GO:0015986)5.90723074
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.51624699
4protein neddylation (GO:0045116)4.50843442
5chaperone-mediated protein transport (GO:0072321)4.49357477
6DNA deamination (GO:0045006)4.41899048
7behavioral response to nicotine (GO:0035095)4.33280288
8regulation of hypersensitivity (GO:0002883)4.15701025
9exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.14754797
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13953810
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.11076209
12NADH dehydrogenase complex assembly (GO:0010257)3.92805288
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92805288
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.92805288
15mitochondrial respiratory chain complex assembly (GO:0033108)3.86758529
16positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.82223219
17protein complex biogenesis (GO:0070271)3.79866779
18respiratory electron transport chain (GO:0022904)3.74211131
19electron transport chain (GO:0022900)3.71726182
20chromatin remodeling at centromere (GO:0031055)3.71430849
21piRNA metabolic process (GO:0034587)3.59723854
22CENP-A containing nucleosome assembly (GO:0034080)3.58527053
23positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.51635975
24water-soluble vitamin biosynthetic process (GO:0042364)3.46399003
25retinal cone cell development (GO:0046549)3.45859848
26histone exchange (GO:0043486)3.44856586
27base-excision repair, AP site formation (GO:0006285)3.44845645
28DNA double-strand break processing (GO:0000729)3.43924712
29termination of RNA polymerase III transcription (GO:0006386)3.41424680
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.41424680
31maturation of 5.8S rRNA (GO:0000460)3.40841391
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.37105290
33preassembly of GPI anchor in ER membrane (GO:0016254)3.31443643
34rRNA modification (GO:0000154)3.31255945
35maturation of SSU-rRNA (GO:0030490)3.29680527
36ATP biosynthetic process (GO:0006754)3.29207503
37organelle disassembly (GO:1903008)3.25436571
38regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.24210702
39nucleotide transmembrane transport (GO:1901679)3.22415869
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.22318137
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.19338150
42DNA damage response, detection of DNA damage (GO:0042769)3.16831637
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16766497
44protein polyglutamylation (GO:0018095)3.15721923
45fucose catabolic process (GO:0019317)3.13228889
46L-fucose metabolic process (GO:0042354)3.13228889
47L-fucose catabolic process (GO:0042355)3.13228889
48DNA replication checkpoint (GO:0000076)3.03819849
49ribosomal large subunit biogenesis (GO:0042273)3.02975394
50GPI anchor biosynthetic process (GO:0006506)2.94886437
51purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93787330
52resolution of meiotic recombination intermediates (GO:0000712)2.93541451
53rRNA methylation (GO:0031167)2.92465477
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92321213
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92321213
56axoneme assembly (GO:0035082)2.92088068
57kynurenine metabolic process (GO:0070189)2.92012357
58DNA methylation involved in gamete generation (GO:0043046)2.89586621
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89134084
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88036982
61regulation of mitotic spindle checkpoint (GO:1903504)2.88036982
62platelet dense granule organization (GO:0060155)2.86073049
63regulation of rhodopsin mediated signaling pathway (GO:0022400)2.85101979
64GPI anchor metabolic process (GO:0006505)2.83450543
65rRNA catabolic process (GO:0016075)2.82205510
66ribonucleoprotein complex disassembly (GO:0032988)2.82030344
67cellular component biogenesis (GO:0044085)2.80264097
68establishment of protein localization to mitochondrial membrane (GO:0090151)2.79698944
69respiratory chain complex IV assembly (GO:0008535)2.77008791
70kinetochore assembly (GO:0051382)2.74087736
71recombinational repair (GO:0000725)2.71634275
72double-strand break repair via homologous recombination (GO:0000724)2.71497658
73proton transport (GO:0015992)2.70540639
74indole-containing compound catabolic process (GO:0042436)2.69889940
75indolalkylamine catabolic process (GO:0046218)2.69889940
76tryptophan catabolic process (GO:0006569)2.69889940
77rRNA metabolic process (GO:0016072)2.68960690
78rhodopsin mediated signaling pathway (GO:0016056)2.68243820
79rRNA processing (GO:0006364)2.67630706
80hydrogen transport (GO:0006818)2.65037008
81intra-S DNA damage checkpoint (GO:0031573)2.64673814
82DNA replication-independent nucleosome assembly (GO:0006336)2.63956046
83DNA replication-independent nucleosome organization (GO:0034724)2.63956046
84regulation of mesoderm development (GO:2000380)2.61169741
85aldehyde catabolic process (GO:0046185)2.60274679
86mitochondrion morphogenesis (GO:0070584)2.59765782
87hydrogen ion transmembrane transport (GO:1902600)2.59376427
88synapsis (GO:0007129)2.57790165
89ribosomal small subunit assembly (GO:0000028)2.56766860
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56633584
91ubiquinone biosynthetic process (GO:0006744)2.55009779
92pseudouridine synthesis (GO:0001522)2.54903961
93kinetochore organization (GO:0051383)2.54717873
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53093697
95viral transcription (GO:0019083)2.53033570
96regulation of cellular amino acid metabolic process (GO:0006521)2.52768552
97protein-cofactor linkage (GO:0018065)2.52519999
98ubiquinone metabolic process (GO:0006743)2.50285957
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49241964
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49233173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36843611
2EST1_17652178_ChIP-ChIP_JURKAT_Human4.24119378
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.06724482
4ZNF274_21170338_ChIP-Seq_K562_Hela3.28437153
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07694793
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97837725
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97257705
8VDR_22108803_ChIP-Seq_LS180_Human2.84109771
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.79431783
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72203516
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54087850
12VDR_23849224_ChIP-Seq_CD4+_Human2.46526273
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27245899
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.24091562
15ELK1_19687146_ChIP-ChIP_HELA_Human2.22718470
16EZH2_22144423_ChIP-Seq_EOC_Human2.19697588
17FOXP3_21729870_ChIP-Seq_TREG_Human2.19199861
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11874206
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09578043
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.91817310
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.80662680
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72351147
23MYC_18940864_ChIP-ChIP_HL60_Human1.69771974
24EWS_26573619_Chip-Seq_HEK293_Human1.69126947
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68716852
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65126983
27IGF1R_20145208_ChIP-Seq_DFB_Human1.64938923
28IRF1_19129219_ChIP-ChIP_H3396_Human1.60057727
29TP53_22573176_ChIP-Seq_HFKS_Human1.54150539
30TTF2_22483619_ChIP-Seq_HELA_Human1.52514914
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52423639
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51452608
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.51448965
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49463869
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46361454
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42994100
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.42644961
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.41094166
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40274722
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.37526626
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37526626
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35076099
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31194474
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30413870
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30221541
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.29262808
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28965365
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26681458
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26573534
50AR_20517297_ChIP-Seq_VCAP_Human1.26213670
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24641272
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24225974
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24126593
54FOXH1_21741376_ChIP-Seq_EPCs_Human1.20847251
55GABP_19822575_ChIP-Seq_HepG2_Human1.19840421
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19686164
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17545070
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.16777114
59NCOR_22424771_ChIP-Seq_293T_Human1.15714886
60ER_23166858_ChIP-Seq_MCF-7_Human1.15092530
61HOXB7_26014856_ChIP-Seq_BT474_Human1.14779427
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14514876
63FUS_26573619_Chip-Seq_HEK293_Human1.14124016
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12263535
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11694863
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11588969
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10758653
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10419778
69GATA3_26560356_Chip-Seq_TH2_Human1.10356957
70P300_19829295_ChIP-Seq_ESCs_Human1.10055091
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09398754
72TAF2_19829295_ChIP-Seq_ESCs_Human1.09306606
73NANOG_19829295_ChIP-Seq_ESCs_Human1.09002158
74SOX2_19829295_ChIP-Seq_ESCs_Human1.09002158
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08597023
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06480017
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04980011
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04433091
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02873957
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02416865
81ERA_21632823_ChIP-Seq_H3396_Human1.02374203
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99980941
83NANOG_20526341_ChIP-Seq_ESCs_Human0.98379264
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98269116
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.98027286
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96327736
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92806133
88CIITA_25753668_ChIP-Seq_RAJI_Human0.92729237
89RBPJ_21746931_ChIP-Seq_IB4_Human0.91698353
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90950085
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89488260
92ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88120350
93E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87531696
94MYC_19829295_ChIP-Seq_ESCs_Human0.87444086
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87325837
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87157297
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.86406022
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85392031
99CBP_20019798_ChIP-Seq_JUKART_Human0.85392031
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84663594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.15417178
2MP0002163_abnormal_gland_morphology3.14926290
3MP0003787_abnormal_imprinting3.06389536
4MP0008877_abnormal_DNA_methylation2.88017474
5MP0005646_abnormal_pituitary_gland2.58120852
6MP0008872_abnormal_physiological_respon2.51949456
7MP0005645_abnormal_hypothalamus_physiol2.50987848
8MP0004147_increased_porphyrin_level2.25168470
9MP0002102_abnormal_ear_morphology2.10532878
10MP0003195_calcinosis2.00994538
11MP0005075_abnormal_melanosome_morpholog1.98493983
12MP0003786_premature_aging1.95163428
13MP0003646_muscle_fatigue1.93426494
14MP0008875_abnormal_xenobiotic_pharmacok1.91705140
15MP0001986_abnormal_taste_sensitivity1.79740035
16MP0003806_abnormal_nucleotide_metabolis1.79519183
17MP0005551_abnormal_eye_electrophysiolog1.79349954
18MP0005379_endocrine/exocrine_gland_phen1.79280277
19MP0002837_dystrophic_cardiac_calcinosis1.71023953
20MP0005377_hearing/vestibular/ear_phenot1.68584086
21MP0003878_abnormal_ear_physiology1.68584086
22MP0001502_abnormal_circadian_rhythm1.62357961
23MP0002876_abnormal_thyroid_physiology1.60853022
24MP0003718_maternal_effect1.60580596
25MP0008058_abnormal_DNA_repair1.59206201
26MP0004142_abnormal_muscle_tone1.56924760
27MP0006035_abnormal_mitochondrial_morpho1.56364395
28MP0005671_abnormal_response_to1.55046491
29MP0003183_abnormal_peptide_metabolism1.54933857
30MP0001968_abnormal_touch/_nociception1.53681514
31MP0001293_anophthalmia1.51739214
32MP0005389_reproductive_system_phenotype1.50368215
33MP0002148_abnormal_hypersensitivity_rea1.45466140
34MP0002736_abnormal_nociception_after1.44972984
35MP0001485_abnormal_pinna_reflex1.44892956
36MP0006036_abnormal_mitochondrial_physio1.42541513
37MP0010094_abnormal_chromosome_stability1.42322199
38MP0003136_yellow_coat_color1.41243222
39MP0002638_abnormal_pupillary_reflex1.35545858
40MP0004885_abnormal_endolymph1.35533581
41MP0001919_abnormal_reproductive_system1.31159906
42MP0000372_irregular_coat_pigmentation1.24999902
43MP0001440_abnormal_grooming_behavior1.24843998
44MP0009764_decreased_sensitivity_to1.24146624
45MP0002277_abnormal_respiratory_mucosa1.20944448
46MP0003693_abnormal_embryo_hatching1.20121743
47MP0009046_muscle_twitch1.20001280
48MP0001501_abnormal_sleep_pattern1.18511839
49MP0002272_abnormal_nervous_system1.18325914
50MP0003121_genomic_imprinting1.16790411
51MP0008789_abnormal_olfactory_epithelium1.16317599
52MP0002160_abnormal_reproductive_system1.16020689
53MP0003011_delayed_dark_adaptation1.15200386
54MP0001790_abnormal_immune_system1.14283109
55MP0005387_immune_system_phenotype1.14283109
56MP0000685_abnormal_immune_system1.13461209
57MP0003122_maternal_imprinting1.12961429
58MP0001835_abnormal_antigen_presentation1.12831787
59MP0001984_abnormal_olfaction1.12558546
60MP0001800_abnormal_humoral_immune1.12305254
61MP0000427_abnormal_hair_cycle1.08867676
62MP0009745_abnormal_behavioral_response1.08845810
63MP0001486_abnormal_startle_reflex1.05854276
64MP0006072_abnormal_retinal_apoptosis1.05563280
65MP0003567_abnormal_fetal_cardiomyocyte1.01488571
66MP0005670_abnormal_white_adipose1.01205049
67MP0005499_abnormal_olfactory_system1.00005572
68MP0005394_taste/olfaction_phenotype1.00005572
69MP0005332_abnormal_amino_acid0.98572060
70MP0001542_abnormal_bone_strength0.97744841
71MP0005360_urolithiasis0.95335972
72MP0008775_abnormal_heart_ventricle0.95079513
73MP0002733_abnormal_thermal_nociception0.92394454
74MP0002938_white_spotting0.90836856
75MP0006276_abnormal_autonomic_nervous0.90516951
76MP0004145_abnormal_muscle_electrophysio0.90495153
77MP0005167_abnormal_blood-brain_barrier0.90073770
78MP0002095_abnormal_skin_pigmentation0.87836236
79MP0001929_abnormal_gametogenesis0.87542770
80MP0004381_abnormal_hair_follicle0.86130992
81MP0005195_abnormal_posterior_eye0.85901136
82MP0001970_abnormal_pain_threshold0.83260365
83MP0004957_abnormal_blastocyst_morpholog0.83244041
84MP0001663_abnormal_digestive_system0.82764741
85MP0004742_abnormal_vestibular_system0.82707317
86MP0000631_abnormal_neuroendocrine_gland0.82609602
87MP0005253_abnormal_eye_physiology0.82207651
88MP0002006_tumorigenesis0.78840315
89MP0002572_abnormal_emotion/affect_behav0.78529577
90MP0004215_abnormal_myocardial_fiber0.77926455
91MP0001905_abnormal_dopamine_level0.76403792
92MP0003724_increased_susceptibility_to0.75905702
93MP0002210_abnormal_sex_determination0.75627796
94MP0002723_abnormal_immune_serum0.74479670
95MP0002234_abnormal_pharynx_morphology0.73450794
96MP0005410_abnormal_fertilization0.72434112
97MP0009785_altered_susceptibility_to0.71549369
98MP0002735_abnormal_chemical_nociception0.70952069
99MP0003698_abnormal_male_reproductive0.70596896
100MP0000653_abnormal_sex_gland0.70331741

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.66152603
2Acute encephalopathy (HP:0006846)4.23599397
3Abnormal mitochondria in muscle tissue (HP:0008316)4.16709927
4Congenital stationary night blindness (HP:0007642)4.14447982
5Mitochondrial inheritance (HP:0001427)3.92686696
6Progressive macrocephaly (HP:0004481)3.84059818
7Increased CSF lactate (HP:0002490)3.80269756
8Abnormality of midbrain morphology (HP:0002418)3.33801314
9Molar tooth sign on MRI (HP:0002419)3.33801314
10Hepatocellular necrosis (HP:0001404)3.16025752
11Lipid accumulation in hepatocytes (HP:0006561)3.15193933
12Pancreatic cysts (HP:0001737)3.09015347
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.04998802
14Oligodactyly (hands) (HP:0001180)3.01618108
15Increased hepatocellular lipid droplets (HP:0006565)2.99617156
16Pancreatic fibrosis (HP:0100732)2.95577825
17Cerebral edema (HP:0002181)2.94135041
18Septo-optic dysplasia (HP:0100842)2.92820834
19Aplasia/Hypoplasia of the spleen (HP:0010451)2.90933306
20True hermaphroditism (HP:0010459)2.84448498
21Absent thumb (HP:0009777)2.80693859
22Sclerocornea (HP:0000647)2.74382315
23Anencephaly (HP:0002323)2.73301992
24Abnormal rod and cone electroretinograms (HP:0008323)2.71357968
25Optic disc pallor (HP:0000543)2.70767542
26Asplenia (HP:0001746)2.68606522
27Hepatic necrosis (HP:0002605)2.67388639
28Reticulocytopenia (HP:0001896)2.63756549
29Abnormality of alanine metabolism (HP:0010916)2.60252773
30Hyperalaninemia (HP:0003348)2.60252773
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60252773
32Nephronophthisis (HP:0000090)2.59566913
33Increased serum lactate (HP:0002151)2.58369783
34Congenital, generalized hypertrichosis (HP:0004540)2.56518937
35IgG deficiency (HP:0004315)2.51974481
36Attenuation of retinal blood vessels (HP:0007843)2.45523782
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43987254
38Renal Fanconi syndrome (HP:0001994)2.41418070
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40202503
40Type II lissencephaly (HP:0007260)2.35348736
41Supernumerary spleens (HP:0009799)2.29468010
42Lethargy (HP:0001254)2.27898684
43Papilledema (HP:0001085)2.27250377
44Lactic acidosis (HP:0003128)2.26701633
45Abnormality of the renal cortex (HP:0011035)2.26517587
46Horseshoe kidney (HP:0000085)2.20347885
47Exertional dyspnea (HP:0002875)2.19849408
48Ectopic kidney (HP:0000086)2.19078922
49Leukodystrophy (HP:0002415)2.16819887
50Pendular nystagmus (HP:0012043)2.15794252
51Abnormality of the renal medulla (HP:0100957)2.12270370
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.11603749
53Anophthalmia (HP:0000528)2.08818944
54Methylmalonic acidemia (HP:0002912)2.08515361
55Increased intramyocellular lipid droplets (HP:0012240)2.05577443
56Respiratory failure (HP:0002878)2.04618433
57Abnormal biliary tract physiology (HP:0012439)2.03963490
58Bile duct proliferation (HP:0001408)2.03963490
59Abolished electroretinogram (ERG) (HP:0000550)2.02398155
60Oligodactyly (HP:0012165)2.02383241
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02321608
62Tetany (HP:0001281)2.01927398
63Abnormality of cells of the erythroid lineage (HP:0012130)2.00979902
64Abnormality of the labia minora (HP:0012880)2.00521136
65Hypomagnesemia (HP:0002917)1.97933053
66Hypothermia (HP:0002045)1.97833732
67Methylmalonic aciduria (HP:0012120)1.96162974
68Meckel diverticulum (HP:0002245)1.95185942
69Hypoproteinemia (HP:0003075)1.94813823
70Cystic liver disease (HP:0006706)1.90723355
71Brittle hair (HP:0002299)1.90522020
72Abnormality of the renal collecting system (HP:0004742)1.89751929
73Abnormality of DNA repair (HP:0003254)1.88158014
74Medial flaring of the eyebrow (HP:0010747)1.88121571
75Polydipsia (HP:0001959)1.86904816
76Abnormal drinking behavior (HP:0030082)1.86904816
77Stenosis of the external auditory canal (HP:0000402)1.86775326
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86529292
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86498022
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86155047
81Abnormality of the ileum (HP:0001549)1.85999304
82Constricted visual fields (HP:0001133)1.84626033
83Lissencephaly (HP:0001339)1.84517375
84Optic nerve hypoplasia (HP:0000609)1.84220461
85Hypoplasia of the pons (HP:0012110)1.84184267
86Duplicated collecting system (HP:0000081)1.83997521
87Absent septum pellucidum (HP:0001331)1.83263638
88Increased muscle lipid content (HP:0009058)1.82662342
89Abnormality of the pons (HP:0007361)1.80878899
90Adactyly (HP:0009776)1.80264605
91Small hand (HP:0200055)1.80171159
92Abnormality of renal resorption (HP:0011038)1.80134791
93Abnormal number of erythroid precursors (HP:0012131)1.79825309
94Tubular atrophy (HP:0000092)1.79175219
95Polyuria (HP:0000103)1.79129238
96Type I transferrin isoform profile (HP:0003642)1.78879481
97X-linked dominant inheritance (HP:0001423)1.78451020
98Renal cortical cysts (HP:0000803)1.77634578
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76082897
100Genetic anticipation (HP:0003743)1.75090023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK14.12642090
2TLK13.25629788
3ZAK3.12929461
4STK162.88602451
5TIE12.79968024
6GRK12.70945579
7TXK2.39685417
8FRK2.32604886
9TAOK32.20853835
10ACVR1B2.11023003
11VRK22.00364368
12ADRBK21.99512333
13BUB11.95675801
14EIF2AK31.92482603
15MAP4K21.82868040
16MKNK11.73255372
17TEC1.66811768
18MAPK131.66310303
19NEK11.64683183
20WNK41.63730043
21MAPKAPK31.61702059
22PLK31.60067188
23MAP4K11.58564284
24MKNK21.56955049
25STK391.54744141
26TRIM281.47739466
27PHKG11.46733546
28PHKG21.46733546
29NME11.41934927
30OXSR11.38100527
31EIF2AK21.34262751
32MAPKAPK51.30205536
33BMPR1B1.28357172
34EIF2AK11.21807005
35TSSK61.21797018
36CSNK1G21.19125383
37MAP2K61.18151410
38VRK11.13356215
39PLK41.12208703
40DYRK21.08301254
41PLK21.06628351
42PLK11.02086220
43WNK31.00834021
44PRKCI0.93800587
45PRKCG0.91764753
46IKBKB0.90345666
47PRKCQ0.88382050
48MUSK0.84319944
49SRPK10.83728659
50MAP2K70.82700375
51NEK20.82644803
52PIK3CG0.79686004
53AURKA0.78977596
54MST40.76841551
55RPS6KA50.72801841
56TNK20.70960051
57ADRBK10.70486647
58AURKB0.69330964
59NTRK20.67817938
60SYK0.67481189
61PINK10.67035240
62INSRR0.63585914
63DAPK20.62406689
64MINK10.61573999
65ITK0.60719839
66PIK3CA0.60292802
67TGFBR10.58867780
68TNIK0.58571051
69BCKDK0.57728876
70KIT0.57556539
71CSNK1G30.56439339
72CDC70.56415090
73TAF10.54233229
74DAPK10.54193420
75FES0.51164628
76CSNK1G10.49209535
77MYLK0.48541655
78CSNK2A20.47520015
79MARK30.46703170
80MAP3K40.45764120
81BMPR20.45113787
82STK30.44037608
83CSNK2A10.42278726
84PRKACA0.41697889
85MARK10.41385566
86PRKCA0.41208054
87PRKCE0.39224137
88ERBB30.38933377
89LYN0.37506483
90ABL20.36605670
91PDK20.36159373
92CHEK20.35292474
93PRKCD0.34523990
94PRKG10.34113705
95CSNK1A10.33326498
96DAPK30.33140296
97DMPK0.32979344
98WEE10.32843014
99CSNK1A1L0.31240649
100ALK0.30585323

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.67932545
2Proteasome_Homo sapiens_hsa030503.54944169
3Parkinsons disease_Homo sapiens_hsa050123.15333165
4Ribosome_Homo sapiens_hsa030102.99637487
5RNA polymerase_Homo sapiens_hsa030202.55026514
6Homologous recombination_Homo sapiens_hsa034402.42455122
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36810970
8Asthma_Homo sapiens_hsa053102.19914970
9Huntingtons disease_Homo sapiens_hsa050162.14887356
10Phototransduction_Homo sapiens_hsa047442.12607672
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.02548759
12Alzheimers disease_Homo sapiens_hsa050101.98498996
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92997536
14RNA degradation_Homo sapiens_hsa030181.92477141
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83291692
16Protein export_Homo sapiens_hsa030601.82337042
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82130637
18Fanconi anemia pathway_Homo sapiens_hsa034601.80411334
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78152589
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72528745
21Linoleic acid metabolism_Homo sapiens_hsa005911.70813229
22Graft-versus-host disease_Homo sapiens_hsa053321.67615521
23Cardiac muscle contraction_Homo sapiens_hsa042601.67116531
24Nitrogen metabolism_Homo sapiens_hsa009101.61973591
25Basal transcription factors_Homo sapiens_hsa030221.61103784
26One carbon pool by folate_Homo sapiens_hsa006701.59593216
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55320944
28Mismatch repair_Homo sapiens_hsa034301.47008095
29Propanoate metabolism_Homo sapiens_hsa006401.45278630
30Sulfur relay system_Homo sapiens_hsa041221.44278029
31Base excision repair_Homo sapiens_hsa034101.42295512
32Nucleotide excision repair_Homo sapiens_hsa034201.41374174
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39926711
34Spliceosome_Homo sapiens_hsa030401.29913495
35Allograft rejection_Homo sapiens_hsa053301.23490312
36Primary immunodeficiency_Homo sapiens_hsa053401.21777944
37DNA replication_Homo sapiens_hsa030301.21133616
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16211940
39Type I diabetes mellitus_Homo sapiens_hsa049401.12472792
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11560491
41Autoimmune thyroid disease_Homo sapiens_hsa053201.10674400
42Sulfur metabolism_Homo sapiens_hsa009201.09860666
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09073033
44Pyrimidine metabolism_Homo sapiens_hsa002401.08822146
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.07988018
46Peroxisome_Homo sapiens_hsa041461.03893225
47Butanoate metabolism_Homo sapiens_hsa006501.01836351
48Tryptophan metabolism_Homo sapiens_hsa003800.99465452
49Purine metabolism_Homo sapiens_hsa002300.98705635
50RNA transport_Homo sapiens_hsa030130.98287541
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97332115
52Nicotine addiction_Homo sapiens_hsa050330.96813282
53Chemical carcinogenesis_Homo sapiens_hsa052040.96694323
54Non-homologous end-joining_Homo sapiens_hsa034500.93887695
55Antigen processing and presentation_Homo sapiens_hsa046120.90426484
56Caffeine metabolism_Homo sapiens_hsa002320.87416239
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80672633
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80223652
59Arachidonic acid metabolism_Homo sapiens_hsa005900.80096381
60Folate biosynthesis_Homo sapiens_hsa007900.79789309
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79462106
62Ether lipid metabolism_Homo sapiens_hsa005650.78617006
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73657026
64Retinol metabolism_Homo sapiens_hsa008300.72689219
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.67005322
66Metabolic pathways_Homo sapiens_hsa011000.63732932
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61040098
68Fat digestion and absorption_Homo sapiens_hsa049750.60050283
69Vitamin digestion and absorption_Homo sapiens_hsa049770.56649584
70Selenocompound metabolism_Homo sapiens_hsa004500.55346516
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54566260
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53781100
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51923489
74Fatty acid degradation_Homo sapiens_hsa000710.51834300
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51471359
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49285685
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48293342
78Steroid biosynthesis_Homo sapiens_hsa001000.47909159
79Olfactory transduction_Homo sapiens_hsa047400.46430703
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46319898
81Morphine addiction_Homo sapiens_hsa050320.43866204
82Fatty acid metabolism_Homo sapiens_hsa012120.43836096
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40251314
84Glycerolipid metabolism_Homo sapiens_hsa005610.40092279
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39941388
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39014128
87Taste transduction_Homo sapiens_hsa047420.35462598
88Rheumatoid arthritis_Homo sapiens_hsa053230.35420094
89Ovarian steroidogenesis_Homo sapiens_hsa049130.33402486
90Fatty acid elongation_Homo sapiens_hsa000620.33152008
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.32275422
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31895807
93Pyruvate metabolism_Homo sapiens_hsa006200.30670211
94Systemic lupus erythematosus_Homo sapiens_hsa053220.28656730
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.28354023
96Serotonergic synapse_Homo sapiens_hsa047260.27466777
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24881835
98Collecting duct acid secretion_Homo sapiens_hsa049660.23666765
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23605678
100African trypanosomiasis_Homo sapiens_hsa051430.23070556

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