HMGB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.53612509
2kinetochore organization (GO:0051383)5.20361617
3DNA strand elongation involved in DNA replication (GO:0006271)5.09776026
4protein localization to chromosome, centromeric region (GO:0071459)4.96964658
5DNA unwinding involved in DNA replication (GO:0006268)4.92229313
6telomere maintenance via semi-conservative replication (GO:0032201)4.90031819
7DNA strand elongation (GO:0022616)4.85366991
8mitotic metaphase plate congression (GO:0007080)4.78601967
9CENP-A containing nucleosome assembly (GO:0034080)4.76891619
10* DNA topological change (GO:0006265)4.72188434
11* DNA ligation (GO:0006266)4.71567578
12chromatin remodeling at centromere (GO:0031055)4.69193372
13mitotic chromosome condensation (GO:0007076)4.66919468
14ribosomal small subunit assembly (GO:0000028)4.62053210
15mitotic sister chromatid segregation (GO:0000070)4.61949279
16DNA replication initiation (GO:0006270)4.60715155
17kinetochore assembly (GO:0051382)4.55915617
18attachment of spindle microtubules to kinetochore (GO:0008608)4.52940232
19telomere maintenance via recombination (GO:0000722)4.45828569
20DNA replication checkpoint (GO:0000076)4.44682352
21mitotic recombination (GO:0006312)4.42388466
22microtubule depolymerization (GO:0007019)4.37846462
23DNA replication-independent nucleosome organization (GO:0034724)4.36234513
24DNA replication-independent nucleosome assembly (GO:0006336)4.36234513
25sister chromatid segregation (GO:0000819)4.36207302
26metaphase plate congression (GO:0051310)4.32264731
27viral transcription (GO:0019083)4.17200970
28establishment of chromosome localization (GO:0051303)4.10949279
29translational termination (GO:0006415)4.08428924
30histone exchange (GO:0043486)3.95825554
31telomere maintenance via telomere lengthening (GO:0010833)3.92750840
32meiotic chromosome segregation (GO:0045132)3.92645071
33maturation of SSU-rRNA (GO:0030490)3.92542035
34regulation of spindle organization (GO:0090224)3.91822642
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89890390
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86959291
37DNA replication-dependent nucleosome organization (GO:0034723)3.86911201
38DNA replication-dependent nucleosome assembly (GO:0006335)3.86911201
39ribosomal small subunit biogenesis (GO:0042274)3.84921003
40mitotic nuclear envelope disassembly (GO:0007077)3.81461678
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.76185952
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.67485863
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.67485863
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.67485863
45DNA packaging (GO:0006323)3.66630869
46translational elongation (GO:0006414)3.64386517
47protein localization to chromosome (GO:0034502)3.58384948
48spindle checkpoint (GO:0031577)3.55628819
49nuclear envelope disassembly (GO:0051081)3.50578811
50membrane disassembly (GO:0030397)3.50578811
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50234423
52DNA deamination (GO:0045006)3.50070276
53translational initiation (GO:0006413)3.46525594
54regulation of centriole replication (GO:0046599)3.46280497
55ribosomal large subunit biogenesis (GO:0042273)3.46155368
56chromosome segregation (GO:0007059)3.44756503
57regulation of chromosome segregation (GO:0051983)3.43707300
58establishment of viral latency (GO:0019043)3.42958892
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42797563
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42546746
61mitotic G2/M transition checkpoint (GO:0044818)3.41643995
62chromatin assembly or disassembly (GO:0006333)3.39860691
63negative regulation of chromosome segregation (GO:0051985)3.37397597
64formation of translation preinitiation complex (GO:0001731)3.37050338
65spindle assembly checkpoint (GO:0071173)3.37049985
66cotranslational protein targeting to membrane (GO:0006613)3.36188540
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35844893
68negative regulation of sister chromatid segregation (GO:0033046)3.35844893
69negative regulation of mitotic sister chromatid separation (GO:2000816)3.35844893
70negative regulation of mitotic sister chromatid segregation (GO:0033048)3.35844893
71positive regulation of chromosome segregation (GO:0051984)3.35675103
72negative regulation of mitosis (GO:0045839)3.35002800
73ATP-dependent chromatin remodeling (GO:0043044)3.33115325
74protein targeting to ER (GO:0045047)3.32364359
75centriole replication (GO:0007099)3.32073411
76nucleobase biosynthetic process (GO:0046112)3.27316824
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27215094
78negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26866407
79cellular protein complex disassembly (GO:0043624)3.26383515
80nuclear pore organization (GO:0006999)3.26040512
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25831461
82mitotic spindle assembly checkpoint (GO:0007094)3.25208764
83regulation of centrosome cycle (GO:0046605)3.25007916
84regulation of mitotic spindle organization (GO:0060236)3.22887476
85regulation of DNA endoreduplication (GO:0032875)3.21727210
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.21475096
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.20473305
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20290368
89chromosome condensation (GO:0030261)3.19316960
90establishment of integrated proviral latency (GO:0075713)3.19027528
91viral life cycle (GO:0019058)3.18525309
92DNA duplex unwinding (GO:0032508)3.18128465
93mitotic spindle checkpoint (GO:0071174)3.18089148
94DNA geometric change (GO:0032392)3.17608672
95negative regulation of mRNA processing (GO:0050686)3.17287106
96deoxyribonucleotide biosynthetic process (GO:0009263)3.17207251
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16665545
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16613477
99negative regulation of RNA splicing (GO:0033119)3.15592963
100mitotic sister chromatid cohesion (GO:0007064)3.14636635
101establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14605100
102ribonucleoprotein complex biogenesis (GO:0022613)3.13984083
103regulation of mitotic sister chromatid separation (GO:0010965)3.11918103
104regulation of mitotic sister chromatid segregation (GO:0033047)3.11918103
105regulation of sister chromatid segregation (GO:0033045)3.11918103
106replication fork processing (GO:0031297)3.10465706
107resolution of meiotic recombination intermediates (GO:0000712)3.10062414
108telomere maintenance (GO:0000723)3.09972653
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09740453
110protein localization to endoplasmic reticulum (GO:0070972)3.09562747
111telomere organization (GO:0032200)3.09127580
112nuclear pore complex assembly (GO:0051292)3.07393814
113* DNA conformation change (GO:0071103)3.06886115
114spliceosomal snRNP assembly (GO:0000387)3.06854917
115non-recombinational repair (GO:0000726)3.04198171
116double-strand break repair via nonhomologous end joining (GO:0006303)3.04198171
117protein complex disassembly (GO:0043241)3.03699133
118negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.02247899
119protein K6-linked ubiquitination (GO:0085020)3.01804092
120chromosome organization (GO:0051276)3.01434304
121regulation of sister chromatid cohesion (GO:0007063)2.99779003
122mitotic cell cycle (GO:0000278)2.99728329
123purine nucleobase biosynthetic process (GO:0009113)2.98327022
124termination of RNA polymerase II transcription (GO:0006369)2.96755305
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96391860
126mRNA splicing, via spliceosome (GO:0000398)2.96391860
127translesion synthesis (GO:0019985)2.96093109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.82114245
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.93825005
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37569218
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.96810941
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.93647879
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53959415
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93979323
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76835262
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.73643140
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61332903
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54672669
12AR_21909140_ChIP-Seq_LNCAP_Human2.45279041
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.45071461
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.41373579
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38736246
16XRN2_22483619_ChIP-Seq_HELA_Human2.32243593
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29465174
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27958454
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26596931
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20681367
21* E2F1_21310950_ChIP-Seq_MCF-7_Human2.18400568
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10503925
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09700724
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08964090
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.08739566
26* VDR_23849224_ChIP-Seq_CD4+_Human2.05553654
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03277838
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.90208560
29DCP1A_22483619_ChIP-Seq_HELA_Human1.83496247
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81987570
31TTF2_22483619_ChIP-Seq_HELA_Human1.79901017
32MYC_22102868_ChIP-Seq_BL_Human1.78908324
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77534274
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74548121
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73981323
36CIITA_25753668_ChIP-Seq_RAJI_Human1.71152858
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69958409
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63319076
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63148550
40GABP_19822575_ChIP-Seq_HepG2_Human1.62423889
41* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61268496
42ELK1_19687146_ChIP-ChIP_HELA_Human1.60410439
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54577070
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53566681
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52882196
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52570011
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49071597
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46549571
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41519440
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38057002
51KDM5A_27292631_Chip-Seq_BREAST_Human1.37977098
52VDR_21846776_ChIP-Seq_THP-1_Human1.35398770
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.34465052
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31086690
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.27930119
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26779858
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26441806
58* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25557867
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25422561
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25008639
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23360616
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21918608
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21674946
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21274921
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10491484
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.10408296
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09694652
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08854819
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08787337
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.08482414
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.07380275
72SPI1_23547873_ChIP-Seq_NB4_Human1.06842624
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06049644
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02868531
75MYC_18940864_ChIP-ChIP_HL60_Human1.01906276
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00325928
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96448242
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94476134
79TFEB_21752829_ChIP-Seq_HELA_Human0.94389644
80* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92925033
81* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91886837
82GATA1_22025678_ChIP-Seq_K562_Human0.90465774
83* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89913822
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.87153603
85* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86575856
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86569195
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86220906
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85391933
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84835595
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83750332
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82735974
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81552754
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81486058
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81119892
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80973933
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.80415018
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79984753
98UTX_26944678_Chip-Seq_JUKART_Human0.79163752
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.79105637
100EWS_26573619_Chip-Seq_HEK293_Human0.78948514
101MYB_26560356_Chip-Seq_TH2_Human0.77712452
102* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77055605
103IRF1_19129219_ChIP-ChIP_H3396_Human0.74649887
104MYB_26560356_Chip-Seq_TH1_Human0.74394070
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.73487380
106MAF_26560356_Chip-Seq_TH1_Human0.73373312
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72739102
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.71808788
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70899258
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.69035785
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68532181
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61453726
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.59633606
114CHD1_26751641_Chip-Seq_LNCaP_Human0.57465542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.79711125
2MP0010094_abnormal_chromosome_stability5.04073148
3MP0003111_abnormal_nucleus_morphology4.86346294
4MP0004957_abnormal_blastocyst_morpholog4.44475008
5MP0003077_abnormal_cell_cycle4.31144962
6MP0008057_abnormal_DNA_replication4.13188680
7MP0008058_abnormal_DNA_repair3.13361744
8MP0008007_abnormal_cellular_replicative2.94204699
9MP0008932_abnormal_embryonic_tissue2.57193818
10MP0002396_abnormal_hematopoietic_system2.55874524
11MP0000350_abnormal_cell_proliferation2.21803047
12MP0004147_increased_porphyrin_level2.19676974
13MP0001730_embryonic_growth_arrest2.16459234
14MP0009697_abnormal_copulation2.06592624
15MP0003123_paternal_imprinting2.00326335
16MP0000490_abnormal_crypts_of1.96094404
17MP0008877_abnormal_DNA_methylation1.88738921
18MP0004808_abnormal_hematopoietic_stem1.75380192
19MP0010307_abnormal_tumor_latency1.74282090
20MP0003786_premature_aging1.72527099
21MP0010352_gastrointestinal_tract_polyps1.70398731
22MP0001697_abnormal_embryo_size1.61319592
23MP0002019_abnormal_tumor_incidence1.58950284
24MP0003763_abnormal_thymus_physiology1.57330593
25MP0005380_embryogenesis_phenotype1.56508064
26MP0001672_abnormal_embryogenesis/_devel1.56508064
27MP0000313_abnormal_cell_death1.51890576
28MP0005397_hematopoietic_system_phenotyp1.49297833
29MP0001545_abnormal_hematopoietic_system1.49297833
30MP0002080_prenatal_lethality1.48885995
31MP0002398_abnormal_bone_marrow1.47179455
32MP0000703_abnormal_thymus_morphology1.45865726
33MP0002085_abnormal_embryonic_tissue1.40473278
34MP0006054_spinal_hemorrhage1.39980043
35MP0009333_abnormal_splenocyte_physiolog1.39713512
36MP0002938_white_spotting1.38198172
37MP0003984_embryonic_growth_retardation1.36273163
38MP0002088_abnormal_embryonic_growth/wei1.32308213
39MP0005076_abnormal_cell_differentiation1.32119729
40MP0002722_abnormal_immune_system1.31938230
41MP0002009_preneoplasia1.29715531
42MP0008995_early_reproductive_senescence1.28226464
43MP0003567_abnormal_fetal_cardiomyocyte1.27620222
44MP0002086_abnormal_extraembryonic_tissu1.27086023
45MP0000566_synostosis1.22611972
46MP0000689_abnormal_spleen_morphology1.22072241
47MP0004197_abnormal_fetal_growth/weight/1.20673758
48MP0002084_abnormal_developmental_patter1.19589388
49MP0001529_abnormal_vocalization1.19105091
50MP0003121_genomic_imprinting1.18239498
51MP0003718_maternal_effect1.17371023
52MP0006036_abnormal_mitochondrial_physio1.16295012
53MP0006292_abnormal_olfactory_placode1.14500880
54MP0008789_abnormal_olfactory_epithelium1.14000344
55MP0009278_abnormal_bone_marrow1.12691420
56MP0006035_abnormal_mitochondrial_morpho1.12509883
57MP0002429_abnormal_blood_cell1.11607335
58MP0002210_abnormal_sex_determination1.08511618
59MP0003806_abnormal_nucleotide_metabolis1.06512553
60MP0000858_altered_metastatic_potential1.05047430
61MP0010030_abnormal_orbit_morphology1.04215260
62MP0000716_abnormal_immune_system1.03748333
63MP0006072_abnormal_retinal_apoptosis1.02007232
64MP0001800_abnormal_humoral_immune1.00811325
65MP0002132_abnormal_respiratory_system0.97862502
66MP0003315_abnormal_perineum_morphology0.97049651
67MP0001293_anophthalmia0.96771733
68MP0001346_abnormal_lacrimal_gland0.96356052
69MP0003890_abnormal_embryonic-extraembry0.96301792
70MP0003136_yellow_coat_color0.95469585
71* MP0001145_abnormal_male_reproductive0.92483102
72MP0000372_irregular_coat_pigmentation0.91662220
73MP0002420_abnormal_adaptive_immunity0.90741528
74MP0001835_abnormal_antigen_presentation0.89135539
75MP0002697_abnormal_eye_size0.89082827
76MP0001819_abnormal_immune_cell0.89052909
77MP0005499_abnormal_olfactory_system0.88929492
78MP0005394_taste/olfaction_phenotype0.88929492
79MP0005671_abnormal_response_to0.87527170
80MP0000685_abnormal_immune_system0.87022828
81MP0001727_abnormal_embryo_implantation0.85251751
82MP0002452_abnormal_antigen_presenting0.84989207
83MP0001853_heart_inflammation0.83828103
84* MP0001929_abnormal_gametogenesis0.81568257
85MP0002102_abnormal_ear_morphology0.79858874
86MP0002405_respiratory_system_inflammati0.77824175
87* MP0000653_abnormal_sex_gland0.77386406
88MP0009379_abnormal_foot_pigmentation0.76762789
89MP0009053_abnormal_anal_canal0.76600716
90MP0001119_abnormal_female_reproductive0.76069568
91MP0002095_abnormal_skin_pigmentation0.75839257
92MP0005075_abnormal_melanosome_morpholog0.75142697
93MP0009672_abnormal_birth_weight0.74369671
94MP0005174_abnormal_tail_pigmentation0.73624066
95* MP0003698_abnormal_male_reproductive0.72808965
96MP0000465_gastrointestinal_hemorrhage0.72597255
97MP0009703_decreased_birth_body0.72181746
98MP0002723_abnormal_immune_serum0.70570052
99MP0002006_tumorigenesis0.70556813
100MP0000477_abnormal_intestine_morphology0.69962679
101MP0003699_abnormal_female_reproductive0.68583439
102MP0002092_abnormal_eye_morphology0.67887000
103MP0009785_altered_susceptibility_to0.67804423
104MP0010155_abnormal_intestine_physiology0.67715946
105MP0003436_decreased_susceptibility_to0.67565915
106MP0003861_abnormal_nervous_system0.67184475
107MP0002111_abnormal_tail_morphology0.65287389
108MP0005384_cellular_phenotype0.64649293
109MP0000537_abnormal_urethra_morphology0.64234717
110MP0003448_altered_tumor_morphology0.64018939
111MP0003186_abnormal_redox_activity0.63681391
112MP0005025_abnormal_response_to0.63662955
113MP0002234_abnormal_pharynx_morphology0.63651275
114MP0002166_altered_tumor_susceptibility0.63294510
115MP0005621_abnormal_cell_physiology0.63268991
116MP0002233_abnormal_nose_morphology0.62931423
117* MP0002161_abnormal_fertility/fecundity0.62186531
118MP0005391_vision/eye_phenotype0.61854427
119MP0000049_abnormal_middle_ear0.61681810
120MP0001915_intracranial_hemorrhage0.61664159
121MP0000428_abnormal_craniofacial_morphol0.61185760
122MP0003943_abnormal_hepatobiliary_system0.60050649
123MP0002160_abnormal_reproductive_system0.59475512
124MP0003656_abnormal_erythrocyte_physiolo0.59225466
125MP0001286_abnormal_eye_development0.59147277
126MP0005023_abnormal_wound_healing0.58404668
127MP0000631_abnormal_neuroendocrine_gland0.57818896
128MP0003221_abnormal_cardiomyocyte_apopto0.57751664
129MP0005389_reproductive_system_phenotype0.57239219
130MP0003937_abnormal_limbs/digits/tail_de0.56998072
131MP0005000_abnormal_immune_tolerance0.56513150
132MP0003119_abnormal_digestive_system0.54800873
133MP0000358_abnormal_cell_content/0.54414632
134MP0001873_stomach_inflammation0.54399626

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.10338259
2Birth length less than 3rd percentile (HP:0003561)4.60135746
3Abnormality of cells of the erythroid lineage (HP:0012130)4.59867236
4Abnormal number of erythroid precursors (HP:0012131)4.38078895
5Chromsome breakage (HP:0040012)4.31145738
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07099212
7Breast hypoplasia (HP:0003187)3.56470305
8Patellar aplasia (HP:0006443)3.55521805
9Abnormality of chromosome stability (HP:0003220)3.36769745
10Colon cancer (HP:0003003)3.32418308
11Aplasia/Hypoplasia of the patella (HP:0006498)3.31875017
12Oral leukoplakia (HP:0002745)3.31852355
13Meckel diverticulum (HP:0002245)3.25754320
14Abnormality of the preputium (HP:0100587)3.22941200
15Pallor (HP:0000980)3.11892132
16Abnormality of the ileum (HP:0001549)3.11755949
17Macrocytic anemia (HP:0001972)3.03311034
18Carpal bone hypoplasia (HP:0001498)3.02149978
19Aplastic anemia (HP:0001915)2.99407305
20Myelodysplasia (HP:0002863)2.98675842
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.94548282
22Medulloblastoma (HP:0002885)2.94015851
23Cortical dysplasia (HP:0002539)2.92618657
24Selective tooth agenesis (HP:0001592)2.91806215
25Small intestinal stenosis (HP:0012848)2.91021388
26Duodenal stenosis (HP:0100867)2.91021388
27Increased nuchal translucency (HP:0010880)2.78985289
2811 pairs of ribs (HP:0000878)2.76602658
29Absent thumb (HP:0009777)2.75461773
30Volvulus (HP:0002580)2.74250090
31Abnormal lung lobation (HP:0002101)2.63356019
32Abnormal number of incisors (HP:0011064)2.62837233
33Impulsivity (HP:0100710)2.60189267
34Absent radius (HP:0003974)2.54272898
35Bone marrow hypocellularity (HP:0005528)2.49100878
36Ectopic kidney (HP:0000086)2.42054542
37Duplicated collecting system (HP:0000081)2.42005131
38Microvesicular hepatic steatosis (HP:0001414)2.40152054
39Agnosia (HP:0010524)2.37860383
40Abnormality of the duodenum (HP:0002246)2.37629315
41Aplasia involving forearm bones (HP:0009822)2.36861371
42Absent forearm bone (HP:0003953)2.36861371
43Sloping forehead (HP:0000340)2.35777058
44Ependymoma (HP:0002888)2.35070737
45IgM deficiency (HP:0002850)2.34151657
46Degeneration of anterior horn cells (HP:0002398)2.33967920
47Abnormality of the anterior horn cell (HP:0006802)2.33967920
48Tracheoesophageal fistula (HP:0002575)2.33608398
49Horseshoe kidney (HP:0000085)2.33298736
50Rough bone trabeculation (HP:0100670)2.32452276
51Neoplasm of the pancreas (HP:0002894)2.27274573
52Atresia of the external auditory canal (HP:0000413)2.27013773
53Proximal placement of thumb (HP:0009623)2.26884897
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25864059
55Triphalangeal thumb (HP:0001199)2.25364438
56Increased hepatocellular lipid droplets (HP:0006565)2.25300293
57Acute necrotizing encephalopathy (HP:0006965)2.24932391
58Basal cell carcinoma (HP:0002671)2.23848109
59Cellular immunodeficiency (HP:0005374)2.21042253
60Lymphoma (HP:0002665)2.17933629
61Nephroblastoma (Wilms tumor) (HP:0002667)2.16817658
62Premature graying of hair (HP:0002216)2.16544564
63Thrombocytosis (HP:0001894)2.16386985
64Abnormality of the carotid arteries (HP:0005344)2.14893568
65Abnormality of B cell number (HP:0010975)2.14893497
66B lymphocytopenia (HP:0010976)2.14893497
67Microretrognathia (HP:0000308)2.13881249
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12219919
69Abnormality of the renal collecting system (HP:0004742)2.11880002
70Embryonal neoplasm (HP:0002898)2.11404910
71Broad distal phalanx of finger (HP:0009836)2.11156375
72Rhabdomyosarcoma (HP:0002859)2.10983741
73Deviation of the thumb (HP:0009603)2.10169904
74Abnormal mitochondria in muscle tissue (HP:0008316)2.10128139
75Acute encephalopathy (HP:0006846)2.09592112
76Abnormality of reticulocytes (HP:0004312)2.08959661
77Cleft eyelid (HP:0000625)2.08907690
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08792306
79Abnormality of cochlea (HP:0000375)2.08235947
80Irregular epiphyses (HP:0010582)2.06191460
81Short thumb (HP:0009778)2.05910652
82Clubbing of toes (HP:0100760)2.03376172
83Hypoplastic pelvis (HP:0008839)2.00504781
84Mitochondrial inheritance (HP:0001427)2.00292249
85Lipid accumulation in hepatocytes (HP:0006561)1.98870595
86Panhypogammaglobulinemia (HP:0003139)1.98105008
87Embryonal renal neoplasm (HP:0011794)1.97744025
88High pitched voice (HP:0001620)1.97697643
89Prominent nose (HP:0000448)1.97455407
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.96601943
91Squamous cell carcinoma (HP:0002860)1.95715990
92Abnormality of DNA repair (HP:0003254)1.95218937
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.95181974
94Cafe-au-lait spot (HP:0000957)1.95116481
95Arteriovenous malformation (HP:0100026)1.92262599
96Short 4th metacarpal (HP:0010044)1.91977493
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91977493
98Abnormality of chromosome segregation (HP:0002916)1.89827512
99Increased CSF lactate (HP:0002490)1.89590205
100Supernumerary spleens (HP:0009799)1.87926502
101Combined immunodeficiency (HP:0005387)1.87093167
102Neoplasm of the colon (HP:0100273)1.86727927
103Acute lymphatic leukemia (HP:0006721)1.86553103
104Multiple enchondromatosis (HP:0005701)1.86439808
105Facial hemangioma (HP:0000329)1.85842948
106Aplasia/Hypoplasia of the thymus (HP:0010515)1.85111332
107Poikilocytosis (HP:0004447)1.85091082
108Hypoplasia of the pons (HP:0012110)1.84978861
109Morphological abnormality of the inner ear (HP:0011390)1.82999733
110Hepatocellular necrosis (HP:0001404)1.81486665
111Overlapping toe (HP:0001845)1.81208079
112High anterior hairline (HP:0009890)1.80713084
113Trismus (HP:0000211)1.79327017
114Pancytopenia (HP:0001876)1.77169478
115Choanal atresia (HP:0000453)1.77114116
116Long clavicles (HP:0000890)1.77036048
117Abnormality of the labia minora (HP:0012880)1.76862397
118Abnormality of the pons (HP:0007361)1.76538403
119Septo-optic dysplasia (HP:0100842)1.75651215
120Duplication of thumb phalanx (HP:0009942)1.75479959
121Missing ribs (HP:0000921)1.73398157
122Abnormality of the septum pellucidum (HP:0007375)1.72016804
123Respiratory difficulties (HP:0002880)1.70883338
124IgG deficiency (HP:0004315)1.70759063
125Optic nerve coloboma (HP:0000588)1.70052617
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69846006
127Absent epiphyses (HP:0010577)1.69846006
128Amaurosis fugax (HP:0100576)1.69147969
129Short middle phalanx of the 5th finger (HP:0004220)1.68463198
130Reticulocytosis (HP:0001923)1.67877167
131Recurrent viral infections (HP:0004429)1.66309877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.22443161
2CDC74.48626831
3WEE14.38750643
4VRK23.58190580
5NEK23.39039022
6EIF2AK12.75609891
7TTK2.45230704
8BRSK22.40528902
9SRPK12.38969916
10NEK12.29870336
11PLK12.08290027
12TESK22.03710452
13ACVR1B2.01807967
14AURKB1.95907694
15PLK41.95781871
16CCNB11.89597713
17VRK11.89302605
18TAF11.88160740
19MKNK11.80429216
20STK161.79548407
21BRSK11.75110359
22ATR1.72050327
23NME21.71463019
24STK101.68382099
25DYRK31.65990086
26CDK71.65821825
27RPS6KA41.64504616
28TLK11.58919165
29MAP3K101.57728544
30RPS6KB21.55884663
31CDK41.52709873
32STK41.49125812
33EIF2AK31.47640572
34TSSK61.39447858
35MAP3K81.39015237
36PLK31.38058672
37CHEK21.37252191
38MKNK21.36144638
39CDK121.32019804
40EEF2K1.31886360
41PASK1.30030275
42MAP4K11.28667623
43AURKA1.25634390
44NUAK11.23368542
45CHEK11.16961622
46SMG11.12810086
47CLK11.10214012
48PAK41.04087692
49LRRK20.93538883
50CDK80.90731742
51PBK0.90425879
52MELK0.87983300
53SCYL20.85161562
54PIM10.85061592
55CDK60.84763560
56ATM0.83718339
57TGFBR10.81875846
58KDR0.81870347
59EIF2AK20.81241186
60CDK20.79015661
61BTK0.77453550
62NME10.74979100
63MST40.73054735
64BRD40.71554246
65TEC0.71278120
66GRK60.69553734
67PNCK0.69329032
68CDK10.64305809
69CSNK2A10.62838886
70TESK10.61923164
71CSNK2A20.58939542
72BLK0.57832287
73FLT30.55138323
74PAK10.53893085
75ZAK0.50196556
76CDK11A0.49155774
77PKN20.46316857
78RPS6KA50.46041538
79CDK150.45920687
80ILK0.45439794
81CDK30.44525735
82CDK180.44518670
83IRAK40.43598281
84CDK90.43010514
85MAP2K30.41166293
86ALK0.41015276
87STK30.40670131
88MARK30.40406915
89PIM20.39322238
90PRKCI0.38785932
91DYRK20.37896605
92CDK140.37817376
93TXK0.35911121
94MAPKAPK30.35831348
95CSF1R0.35660601
96ZAP700.35183832
97MAPK110.35102794
98LYN0.34962048
99EPHA20.33850958
100TRIM280.31061706
101PRKDC0.29789237
102TNIK0.28491715
103BRAF0.28294013
104CDK190.28289644
105YES10.27964293
106SYK0.26058348
107TYK20.25507854
108AKT20.24673397
109MAPKAPK20.24413205
110KIT0.23810389
111UHMK10.22384136
112BMPR1B0.21941276
113MAP3K110.21721271
114BCKDK0.21677025
115ITK0.20874645
116RAF10.20643254
117RPS6KC10.20277281
118RPS6KL10.20277281
119MAPK140.20102485
120WNK30.18027201
121MAPKAPK50.17692275
122CSNK1E0.17605546
123PLK20.17389210
124GSK3B0.12940823
125AKT10.09805125
126MINK10.08159531
127MAPK90.06548618
128BCR0.06258184

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.50597733
2Mismatch repair_Homo sapiens_hsa034304.56507950
3Ribosome_Homo sapiens_hsa030103.75387053
4Spliceosome_Homo sapiens_hsa030403.52469883
5Homologous recombination_Homo sapiens_hsa034403.42319065
6Base excision repair_Homo sapiens_hsa034103.32062207
7Cell cycle_Homo sapiens_hsa041103.13154133
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00216302
9Nucleotide excision repair_Homo sapiens_hsa034202.91142875
10RNA transport_Homo sapiens_hsa030132.82765889
11Proteasome_Homo sapiens_hsa030502.68502173
12RNA polymerase_Homo sapiens_hsa030202.65779203
13Fanconi anemia pathway_Homo sapiens_hsa034602.49452162
14Pyrimidine metabolism_Homo sapiens_hsa002402.34261841
15Non-homologous end-joining_Homo sapiens_hsa034502.26432839
16One carbon pool by folate_Homo sapiens_hsa006702.22586151
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87126389
18RNA degradation_Homo sapiens_hsa030181.86893926
19p53 signaling pathway_Homo sapiens_hsa041151.74096828
20Basal transcription factors_Homo sapiens_hsa030221.73090269
21mRNA surveillance pathway_Homo sapiens_hsa030151.70035689
22Oxidative phosphorylation_Homo sapiens_hsa001901.51309244
23Systemic lupus erythematosus_Homo sapiens_hsa053221.39466140
24Primary immunodeficiency_Homo sapiens_hsa053401.24125225
25Epstein-Barr virus infection_Homo sapiens_hsa051691.20107804
26Purine metabolism_Homo sapiens_hsa002301.14384284
27Herpes simplex infection_Homo sapiens_hsa051681.13286784
28Oocyte meiosis_Homo sapiens_hsa041141.10564703
29Antigen processing and presentation_Homo sapiens_hsa046121.09398418
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09157930
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08900525
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06270987
33Viral carcinogenesis_Homo sapiens_hsa052030.98732255
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94929902
35HTLV-I infection_Homo sapiens_hsa051660.89067315
36Pyruvate metabolism_Homo sapiens_hsa006200.86768266
37Pentose phosphate pathway_Homo sapiens_hsa000300.82054292
38Alzheimers disease_Homo sapiens_hsa050100.81066908
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80731564
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79225293
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74891314
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73209615
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72993487
44Small cell lung cancer_Homo sapiens_hsa052220.71258339
45MicroRNAs in cancer_Homo sapiens_hsa052060.68028871
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65280073
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64272492
48Propanoate metabolism_Homo sapiens_hsa006400.60570558
49Measles_Homo sapiens_hsa051620.59938209
50Protein export_Homo sapiens_hsa030600.59281462
51Fatty acid elongation_Homo sapiens_hsa000620.57582693
52Legionellosis_Homo sapiens_hsa051340.56983343
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56351113
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.55767338
55Thyroid cancer_Homo sapiens_hsa052160.54812080
56Apoptosis_Homo sapiens_hsa042100.53813651
57Folate biosynthesis_Homo sapiens_hsa007900.53678774
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.53088621
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.52781767
60Hepatitis B_Homo sapiens_hsa051610.52669088
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52635891
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51471954
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.51319741
64Hematopoietic cell lineage_Homo sapiens_hsa046400.50197929
65Alcoholism_Homo sapiens_hsa050340.49230581
66Colorectal cancer_Homo sapiens_hsa052100.47822643
67Steroid biosynthesis_Homo sapiens_hsa001000.47045235
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46436139
69Selenocompound metabolism_Homo sapiens_hsa004500.46099418
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45266257
71Shigellosis_Homo sapiens_hsa051310.44330087
72Chronic myeloid leukemia_Homo sapiens_hsa052200.43922270
73Biosynthesis of amino acids_Homo sapiens_hsa012300.43529646
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.43140426
75Huntingtons disease_Homo sapiens_hsa050160.42840988
76Sulfur relay system_Homo sapiens_hsa041220.41938168
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40524362
78Notch signaling pathway_Homo sapiens_hsa043300.39986307
79Glutathione metabolism_Homo sapiens_hsa004800.38366897
80Leishmaniasis_Homo sapiens_hsa051400.37507359
81Viral myocarditis_Homo sapiens_hsa054160.35039720
82Asthma_Homo sapiens_hsa053100.34604607
83Basal cell carcinoma_Homo sapiens_hsa052170.34092627
84B cell receptor signaling pathway_Homo sapiens_hsa046620.34039376
85Metabolic pathways_Homo sapiens_hsa011000.33233155
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32776573
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32120374
88Influenza A_Homo sapiens_hsa051640.31740308
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31507204
90N-Glycan biosynthesis_Homo sapiens_hsa005100.30641121
91TGF-beta signaling pathway_Homo sapiens_hsa043500.29774110
92Pathways in cancer_Homo sapiens_hsa052000.28203138
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27251192
94Parkinsons disease_Homo sapiens_hsa050120.26919886
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26100255
96Bladder cancer_Homo sapiens_hsa052190.26034879
97Hippo signaling pathway_Homo sapiens_hsa043900.24931215
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24870740
99Acute myeloid leukemia_Homo sapiens_hsa052210.24529637
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.24380128
101Allograft rejection_Homo sapiens_hsa053300.24345054
102Graft-versus-host disease_Homo sapiens_hsa053320.23937635
103Wnt signaling pathway_Homo sapiens_hsa043100.23494252
104Non-small cell lung cancer_Homo sapiens_hsa052230.23328320
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23320425
106T cell receptor signaling pathway_Homo sapiens_hsa046600.22546959
107Pancreatic cancer_Homo sapiens_hsa052120.22248295
108Hedgehog signaling pathway_Homo sapiens_hsa043400.19296842
109Carbon metabolism_Homo sapiens_hsa012000.17783762
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16794216
111Prostate cancer_Homo sapiens_hsa052150.16611161
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15730954
113HIF-1 signaling pathway_Homo sapiens_hsa040660.15674459
114Renin-angiotensin system_Homo sapiens_hsa046140.15158988
115Cardiac muscle contraction_Homo sapiens_hsa042600.15106903
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.15023962
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15012452
118Fatty acid metabolism_Homo sapiens_hsa012120.14446693
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14377985
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14202001
121FoxO signaling pathway_Homo sapiens_hsa040680.13335792
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.13275165
123Vitamin B6 metabolism_Homo sapiens_hsa007500.13041399
124Lysine degradation_Homo sapiens_hsa003100.09759635
125Butanoate metabolism_Homo sapiens_hsa006500.07148775
126Fructose and mannose metabolism_Homo sapiens_hsa000510.05983466
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03801742
128Nitrogen metabolism_Homo sapiens_hsa009100.02862856
129Olfactory transduction_Homo sapiens_hsa047400.02708843

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »