HMGB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)4.49021287
2DNA unwinding involved in DNA replication (GO:0006268)4.44935825
3DNA topological change (GO:0006265)4.34600171
4protein localization to kinetochore (GO:0034501)4.27956684
5kinetochore assembly (GO:0051382)4.27869702
6mitotic metaphase plate congression (GO:0007080)4.23843934
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.22547829
8DNA strand elongation involved in DNA replication (GO:0006271)4.17494544
9negative regulation of RNA splicing (GO:0033119)4.06732304
10DNA replication-independent nucleosome organization (GO:0034724)4.01648187
11DNA replication-independent nucleosome assembly (GO:0006336)4.01648187
12CENP-A containing nucleosome assembly (GO:0034080)4.01295037
13DNA strand elongation (GO:0022616)4.00096363
14chromatin remodeling at centromere (GO:0031055)3.89844540
15protein localization to chromosome, centromeric region (GO:0071459)3.88785885
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.83429394
17DNA replication initiation (GO:0006270)3.82887998
18telomere maintenance via semi-conservative replication (GO:0032201)3.81946436
19mitotic sister chromatid segregation (GO:0000070)3.78543393
20mitotic chromosome condensation (GO:0007076)3.76736651
21sister chromatid segregation (GO:0000819)3.73820295
22establishment of viral latency (GO:0019043)3.72285016
23metaphase plate congression (GO:0051310)3.71052428
24spindle checkpoint (GO:0031577)3.70788727
25spindle assembly checkpoint (GO:0071173)3.69782523
26DNA replication checkpoint (GO:0000076)3.69278233
27viral mRNA export from host cell nucleus (GO:0046784)3.69107665
28attachment of spindle microtubules to kinetochore (GO:0008608)3.66674791
29mitotic spindle assembly checkpoint (GO:0007094)3.66557249
30microtubule depolymerization (GO:0007019)3.65914399
31negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.64286202
32negative regulation of sister chromatid segregation (GO:0033046)3.64286202
33negative regulation of mitotic sister chromatid separation (GO:2000816)3.64286202
34negative regulation of mitotic sister chromatid segregation (GO:0033048)3.64286202
35negative regulation of mRNA processing (GO:0050686)3.61593926
36negative regulation of chromosome segregation (GO:0051985)3.61478543
37DNA replication-dependent nucleosome assembly (GO:0006335)3.57363766
38DNA replication-dependent nucleosome organization (GO:0034723)3.57363766
39mitotic spindle checkpoint (GO:0071174)3.54538169
40mitotic recombination (GO:0006312)3.53900914
41negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.53555132
42maturation of SSU-rRNA (GO:0030490)3.53038598
43spliceosomal snRNP assembly (GO:0000387)3.52587072
44histone exchange (GO:0043486)3.51589546
45ribosomal small subunit assembly (GO:0000028)3.46115711
46telomere maintenance via recombination (GO:0000722)3.45802795
47regulation of chromosome segregation (GO:0051983)3.42593014
48histone H2A acetylation (GO:0043968)3.39792632
49mitotic nuclear envelope disassembly (GO:0007077)3.37283695
50spliceosomal complex assembly (GO:0000245)3.36687694
51ATP-dependent chromatin remodeling (GO:0043044)3.36599220
52regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35475779
53DNA damage response, detection of DNA damage (GO:0042769)3.35352945
54RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.35187426
55mRNA splicing, via spliceosome (GO:0000398)3.35187426
56viral transcription (GO:0019083)3.33822222
57RNA splicing, via transesterification reactions (GO:0000375)3.33362728
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32645356
59establishment of chromosome localization (GO:0051303)3.29052926
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27838371
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.27803080
62mitotic sister chromatid cohesion (GO:0007064)3.27410271
63translational termination (GO:0006415)3.26645097
64termination of RNA polymerase II transcription (GO:0006369)3.26524655
65regulation of spindle organization (GO:0090224)3.26023664
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24321699
67heterochromatin organization (GO:0070828)3.24258903
68regulation of sister chromatid segregation (GO:0033045)3.23686358
69regulation of mitotic sister chromatid separation (GO:0010965)3.23686358
70regulation of mitotic sister chromatid segregation (GO:0033047)3.23686358
71regulation of centriole replication (GO:0046599)3.22119266
72DNA double-strand break processing (GO:0000729)3.13010136
73telomere maintenance via telomere lengthening (GO:0010833)3.12271096
74regulation of mitotic spindle checkpoint (GO:1903504)3.11631894
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11631894
76ribosomal small subunit biogenesis (GO:0042274)3.10966726
77membrane disassembly (GO:0030397)3.10865935
78nuclear envelope disassembly (GO:0051081)3.10865935
79chromosome segregation (GO:0007059)3.10126088
80regulation of helicase activity (GO:0051095)3.09970972
81protein complex localization (GO:0031503)3.09875534
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08185698
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.07600133
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06531119
85chromatin assembly or disassembly (GO:0006333)3.04745359
86pre-miRNA processing (GO:0031054)3.04121718
87nucleobase biosynthetic process (GO:0046112)3.03468274
88regulation of posttranscriptional gene silencing (GO:0060147)3.03025289
89regulation of gene silencing by miRNA (GO:0060964)3.03025289
90regulation of gene silencing by RNA (GO:0060966)3.03025289
91purine nucleobase biosynthetic process (GO:0009113)3.02773082
92protein localization to chromosome (GO:0034502)3.02500740
93mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01969123
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01498605
95nuclear pore complex assembly (GO:0051292)3.00697994
96L-serine metabolic process (GO:0006563)2.99627167
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98970102
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98328189
99translational initiation (GO:0006413)2.97137306
100proteasome assembly (GO:0043248)2.97055514
101establishment of integrated proviral latency (GO:0075713)2.95676671
102meiotic chromosome segregation (GO:0045132)2.92786182
103regulation of double-strand break repair via homologous recombination (GO:0010569)2.92375606
104formation of translation preinitiation complex (GO:0001731)2.91791428
105translational elongation (GO:0006414)2.91130495
106regulation of DNA damage checkpoint (GO:2000001)2.90974936
107IMP biosynthetic process (GO:0006188)2.88288913
108negative regulation of mitosis (GO:0045839)2.88174527
109ribosome assembly (GO:0042255)2.87931198
110DNA ligation (GO:0006266)2.87334695
111paraxial mesoderm development (GO:0048339)2.87155802
112histone mRNA metabolic process (GO:0008334)2.86570630
113negative regulation of mRNA metabolic process (GO:1903312)2.85968733
114nuclear pore organization (GO:0006999)2.85434085
115ribonucleoprotein complex biogenesis (GO:0022613)2.85272000
116peptidyl-arginine omega-N-methylation (GO:0035247)2.84624998
117deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83853896
118alternative mRNA splicing, via spliceosome (GO:0000380)2.83644113
119positive regulation of chromosome segregation (GO:0051984)2.82667176
120RNA export from nucleus (GO:0006405)2.82603580
121regulation of sister chromatid cohesion (GO:0007063)2.81261154
122double-strand break repair via nonhomologous end joining (GO:0006303)2.77683914
123non-recombinational repair (GO:0000726)2.77683914
124chaperone-mediated protein transport (GO:0072321)2.74567878
125regulation of centrosome cycle (GO:0046605)2.68898050
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.68773093
127somatic hypermutation of immunoglobulin genes (GO:0016446)2.64615203
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64615203
129negative regulation of ligase activity (GO:0051352)2.62185522
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62185522
131regulation of DNA endoreduplication (GO:0032875)2.60458964
132IMP metabolic process (GO:0046040)2.59772774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.08853635
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.48203700
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39976885
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.26709251
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.89817357
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61183266
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29785861
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98661386
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.94908264
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88845337
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83988132
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78051279
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.75880782
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69900908
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.69466230
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67446528
17XRN2_22483619_ChIP-Seq_HELA_Human2.62076434
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56064295
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.49783337
20AR_21909140_ChIP-Seq_LNCAP_Human2.43214345
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41499555
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39437296
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30668857
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20930049
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.20643660
26TTF2_22483619_ChIP-Seq_HELA_Human2.18949018
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15870735
28* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09869884
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07956359
30VDR_23849224_ChIP-Seq_CD4+_Human2.07359781
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04069683
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02439839
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98867346
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94487415
35CIITA_25753668_ChIP-Seq_RAJI_Human1.93526474
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92227824
37FOXP3_21729870_ChIP-Seq_TREG_Human1.91215540
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89817251
39GABP_19822575_ChIP-Seq_HepG2_Human1.89399260
40DCP1A_22483619_ChIP-Seq_HELA_Human1.86826249
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84142071
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80605004
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71661746
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67672452
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66284249
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65527741
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62843836
48ELK1_19687146_ChIP-ChIP_HELA_Human1.61419913
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59841316
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59079021
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57818079
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.54113732
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52033339
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45705465
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45282052
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45282052
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45282052
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43039946
59KDM5A_27292631_Chip-Seq_BREAST_Human1.42939986
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41674111
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38936876
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36076709
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35923509
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34883391
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33375072
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32856804
67MYC_18940864_ChIP-ChIP_HL60_Human1.29190047
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28077784
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25024695
70FUS_26573619_Chip-Seq_HEK293_Human1.22837405
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20334582
72MYC_22102868_ChIP-Seq_BL_Human1.19458609
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18518346
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.16266295
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16169921
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15286081
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14380640
78* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13718026
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.13342109
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10261006
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.08576244
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07736971
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.04898396
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.02912909
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02436109
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01504847
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.01367048
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01168799
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98171162
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97882503
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96716658
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95857470
93* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95581766
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95089196
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93716646
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.92812424
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91554940
98ZNF274_21170338_ChIP-Seq_K562_Hela0.89674725
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89030823
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88329221
101* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87615809
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87609057
103TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86143832
104* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83537726
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82054383
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80451953
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79800986
108* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.78971325
109* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77902291
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76608048
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75073861
112EWS_26573619_Chip-Seq_HEK293_Human0.74842528
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.74444210
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73003948
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71303746
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71232732
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70114786
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.69410108
119VDR_22108803_ChIP-Seq_LS180_Human0.68195390
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.65754068
121CHD1_26751641_Chip-Seq_LNCaP_Human0.65654989
122IRF1_19129219_ChIP-ChIP_H3396_Human0.64031015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.16456788
2MP0003111_abnormal_nucleus_morphology3.93260208
3MP0010094_abnormal_chromosome_stability3.87934713
4MP0003077_abnormal_cell_cycle3.44586319
5MP0004957_abnormal_blastocyst_morpholog3.32372551
6MP0008057_abnormal_DNA_replication3.01829842
7MP0008058_abnormal_DNA_repair2.83761925
8MP0003123_paternal_imprinting2.75942390
9MP0000537_abnormal_urethra_morphology2.58931333
10MP0008007_abnormal_cellular_replicative2.54319187
11MP0008932_abnormal_embryonic_tissue2.43996675
12MP0010030_abnormal_orbit_morphology2.43105868
13MP0003941_abnormal_skin_development2.41250124
14MP0003315_abnormal_perineum_morphology2.39690168
15MP0002102_abnormal_ear_morphology2.34326800
16MP0003121_genomic_imprinting2.19921353
17MP0006292_abnormal_olfactory_placode2.13677903
18MP0009053_abnormal_anal_canal2.11404514
19MP0008877_abnormal_DNA_methylation1.97504515
20MP0002938_white_spotting1.95974565
21MP0001730_embryonic_growth_arrest1.85776882
22MP0003890_abnormal_embryonic-extraembry1.82098585
23MP0008789_abnormal_olfactory_epithelium1.78205526
24MP0000350_abnormal_cell_proliferation1.75502966
25MP0003567_abnormal_fetal_cardiomyocyte1.71757377
26MP0000049_abnormal_middle_ear1.68371435
27MP0003786_premature_aging1.64715952
28MP0000566_synostosis1.59693959
29MP0008995_early_reproductive_senescence1.57062353
30MP0003122_maternal_imprinting1.57055740
31MP0002085_abnormal_embryonic_tissue1.57009275
32MP0003136_yellow_coat_color1.55531973
33MP0002396_abnormal_hematopoietic_system1.54507571
34MP0003938_abnormal_ear_development1.53883892
35MP0003937_abnormal_limbs/digits/tail_de1.53848532
36MP0001697_abnormal_embryo_size1.52405899
37MP0005380_embryogenesis_phenotype1.50277623
38MP0001672_abnormal_embryogenesis/_devel1.50277623
39MP0004133_heterotaxia1.47892058
40MP0001188_hyperpigmentation1.45724630
41MP0002084_abnormal_developmental_patter1.44231764
42MP0009379_abnormal_foot_pigmentation1.40711616
43MP0009697_abnormal_copulation1.39251512
44MP0000579_abnormal_nail_morphology1.37897575
45MP0002210_abnormal_sex_determination1.37140617
46MP0003942_abnormal_urinary_system1.36904584
47MP0001293_anophthalmia1.35564629
48MP0003984_embryonic_growth_retardation1.32523632
49MP0003119_abnormal_digestive_system1.32297497
50MP0002080_prenatal_lethality1.32079958
51MP0002088_abnormal_embryonic_growth/wei1.30779224
52MP0004147_increased_porphyrin_level1.29947632
53MP0005499_abnormal_olfactory_system1.28765781
54MP0005394_taste/olfaction_phenotype1.28765781
55MP0003385_abnormal_body_wall1.27916682
56MP0003861_abnormal_nervous_system1.27054224
57MP0001529_abnormal_vocalization1.23610369
58MP0004197_abnormal_fetal_growth/weight/1.20407413
59MP0002751_abnormal_autonomic_nervous1.18417475
60MP0001145_abnormal_male_reproductive1.16711176
61MP0006072_abnormal_retinal_apoptosis1.12048150
62MP0006054_spinal_hemorrhage1.11986504
63MP0005187_abnormal_penis_morphology1.11081348
64MP0000631_abnormal_neuroendocrine_gland1.11061462
65MP0003115_abnormal_respiratory_system1.10393856
66MP0002653_abnormal_ependyma_morphology1.10339229
67MP0003221_abnormal_cardiomyocyte_apopto1.10144247
68MP0003718_maternal_effect1.09110394
69MP0000313_abnormal_cell_death1.08216264
70MP0001286_abnormal_eye_development1.06980749
71MP0000490_abnormal_crypts_of1.06660873
72MP0004808_abnormal_hematopoietic_stem1.06406792
73MP0000428_abnormal_craniofacial_morphol1.05074326
74MP0000778_abnormal_nervous_system1.05050571
75MP0003935_abnormal_craniofacial_develop1.04222318
76MP0002932_abnormal_joint_morphology1.04063372
77MP0000653_abnormal_sex_gland1.02832036
78MP0002254_reproductive_system_inflammat1.02790346
79MP0003755_abnormal_palate_morphology1.02511426
80MP0009672_abnormal_birth_weight0.99859926
81MP0001299_abnormal_eye_distance/0.99758086
82MP0002086_abnormal_extraembryonic_tissu0.99466230
83MP0002282_abnormal_trachea_morphology0.99232144
84MP0001346_abnormal_lacrimal_gland0.98896579
85MP0009250_abnormal_appendicular_skeleto0.97096305
86MP0002233_abnormal_nose_morphology0.94982810
87MP0001929_abnormal_gametogenesis0.94772667
88MP0003656_abnormal_erythrocyte_physiolo0.93968708
89MP0002249_abnormal_larynx_morphology0.93691949
90MP0000569_abnormal_digit_pigmentation0.93371168
91MP0000647_abnormal_sebaceous_gland0.92750329
92MP0002697_abnormal_eye_size0.91109842
93MP0002116_abnormal_craniofacial_bone0.90147536
94MP0010307_abnormal_tumor_latency0.89507797
95MP0002111_abnormal_tail_morphology0.88107508
96MP0001119_abnormal_female_reproductive0.87045757
97MP0000762_abnormal_tongue_morphology0.86552314
98MP0006035_abnormal_mitochondrial_morpho0.86249511
99MP0002114_abnormal_axial_skeleton0.85623205
100MP0005391_vision/eye_phenotype0.85225484
101MP0002092_abnormal_eye_morphology0.85058304
102MP0000534_abnormal_ureter_morphology0.84208452
103MP0002160_abnormal_reproductive_system0.83792004
104MP0005397_hematopoietic_system_phenotyp0.80653884
105MP0001545_abnormal_hematopoietic_system0.80653884
106MP0002081_perinatal_lethality0.80370797
107MP0002736_abnormal_nociception_after0.79952027
108MP0002163_abnormal_gland_morphology0.76181619
109MP0010352_gastrointestinal_tract_polyps0.76077089
110MP0002234_abnormal_pharynx_morphology0.75177707
111MP0001177_atelectasis0.73966809
112MP0006276_abnormal_autonomic_nervous0.72630381
113MP0001984_abnormal_olfaction0.71343745
114MP0002796_impaired_skin_barrier0.71127328
115MP0009703_decreased_birth_body0.69520371
116MP0000432_abnormal_head_morphology0.69273935
117MP0003186_abnormal_redox_activity0.68812998
118MP0005248_abnormal_Harderian_gland0.68495892
119MP0002019_abnormal_tumor_incidence0.68181330
120MP0003698_abnormal_male_reproductive0.68110760
121MP0003787_abnormal_imprinting0.67991231
122MP0001485_abnormal_pinna_reflex0.66851769
123MP0002152_abnormal_brain_morphology0.66143926
124MP0005501_abnormal_skin_physiology0.61769073

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)3.86926708
2Abnormality of cells of the erythroid lineage (HP:0012130)3.86799387
3Abnormality of the heme biosynthetic pathway (HP:0010472)3.79137927
4Patellar aplasia (HP:0006443)3.72221014
5Birth length less than 3rd percentile (HP:0003561)3.65695758
6Aplasia/Hypoplasia of the patella (HP:0006498)3.57079399
7Reticulocytopenia (HP:0001896)3.48000893
8Septo-optic dysplasia (HP:0100842)3.23167157
9Short 4th metacarpal (HP:0010044)3.13371203
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.13371203
11Colon cancer (HP:0003003)3.03370025
12Cortical dysplasia (HP:0002539)3.02437039
13Abnormal lung lobation (HP:0002101)3.01910500
14Medulloblastoma (HP:0002885)2.89651333
15Oral leukoplakia (HP:0002745)2.77983410
16Breast hypoplasia (HP:0003187)2.76417930
17Increased nuchal translucency (HP:0010880)2.76365162
18Aplastic anemia (HP:0001915)2.74160706
19Nephroblastoma (Wilms tumor) (HP:0002667)2.71694587
20Short middle phalanx of the 5th finger (HP:0004220)2.61067982
21Chromsome breakage (HP:0040012)2.59821592
22Abnormal number of incisors (HP:0011064)2.57048710
23Embryonal renal neoplasm (HP:0011794)2.56501080
24Facial hemangioma (HP:0000329)2.55828580
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54840364
26Meckel diverticulum (HP:0002245)2.52225632
27Aplasia/Hypoplasia of the sternum (HP:0006714)2.46886458
28Shoulder girdle muscle weakness (HP:0003547)2.46821875
29Volvulus (HP:0002580)2.45614500
30Abnormality of the ileum (HP:0001549)2.45335637
31Absent septum pellucidum (HP:0001331)2.44562660
32Abnormality of the septum pellucidum (HP:0007375)2.44554634
33Abnormality of the 4th metacarpal (HP:0010012)2.43879746
34Pallor (HP:0000980)2.43629861
35Small intestinal stenosis (HP:0012848)2.42766568
36Duodenal stenosis (HP:0100867)2.42766568
37Renal duplication (HP:0000075)2.40785928
3811 pairs of ribs (HP:0000878)2.40713296
39Atresia of the external auditory canal (HP:0000413)2.37445181
40Abnormality of the labia minora (HP:0012880)2.32270775
41Increased hepatocellular lipid droplets (HP:0006565)2.30807552
42Selective tooth agenesis (HP:0001592)2.30731082
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.27033878
44High anterior hairline (HP:0009890)2.26848809
45Abnormality of the preputium (HP:0100587)2.24863948
46Degeneration of anterior horn cells (HP:0002398)2.22257038
47Abnormality of the anterior horn cell (HP:0006802)2.22257038
48Esophageal atresia (HP:0002032)2.21302597
49Bilateral microphthalmos (HP:0007633)2.18156829
50Horseshoe kidney (HP:0000085)2.17516484
51Acute necrotizing encephalopathy (HP:0006965)2.17126603
52Stenosis of the external auditory canal (HP:0000402)2.15851049
53Spastic diplegia (HP:0001264)2.14800005
54Macrocytic anemia (HP:0001972)2.13280989
55Impulsivity (HP:0100710)2.11557666
56Abnormality of chromosome stability (HP:0003220)2.11063093
57Proximal placement of thumb (HP:0009623)2.09930970
58Pelvic girdle muscle weakness (HP:0003749)2.09849514
59Hepatoblastoma (HP:0002884)2.09460031
60Acute encephalopathy (HP:0006846)2.08080627
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06347787
62Ectopic kidney (HP:0000086)2.05901000
63Abnormality of the intervertebral disk (HP:0005108)2.05812108
64Ependymoma (HP:0002888)2.05239223
65Carpal bone hypoplasia (HP:0001498)2.03451276
66Myelodysplasia (HP:0002863)2.01565391
67Neoplasm of the pancreas (HP:0002894)2.00062318
68Abnormality of the duodenum (HP:0002246)1.98662405
69Lipid accumulation in hepatocytes (HP:0006561)1.97936875
70Rough bone trabeculation (HP:0100670)1.93849937
71Anophthalmia (HP:0000528)1.93154350
72Hyperglycinemia (HP:0002154)1.92951014
73Embryonal neoplasm (HP:0002898)1.91206419
74Triphalangeal thumb (HP:0001199)1.89815176
75Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.88573603
76Diastasis recti (HP:0001540)1.87756692
77Maternal diabetes (HP:0009800)1.86125365
78Sloping forehead (HP:0000340)1.86005813
79Deviation of the thumb (HP:0009603)1.84869919
80Glioma (HP:0009733)1.84717623
81Short 5th finger (HP:0009237)1.84362575
82Abnormal mitochondria in muscle tissue (HP:0008316)1.84220676
83Atrophy/Degeneration involving motor neurons (HP:0007373)1.84008909
84Hypoplastic pelvis (HP:0008839)1.83409279
85Abnormality of the musculature of the pelvis (HP:0001469)1.81794185
86Abnormality of the hip-girdle musculature (HP:0001445)1.81794185
87Broad distal phalanx of finger (HP:0009836)1.81685661
88Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81360640
89Hemivertebrae (HP:0002937)1.80785495
90Abdominal situs inversus (HP:0003363)1.80352464
91Abnormality of abdominal situs (HP:0011620)1.80352464
92Microretrognathia (HP:0000308)1.80076153
93Oligodactyly (HP:0012165)1.79726469
94Neoplasm of the colon (HP:0100273)1.78949318
95Rimmed vacuoles (HP:0003805)1.78903589
96Bifid tongue (HP:0010297)1.78693868
97Hypoplastic female external genitalia (HP:0012815)1.77681758
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77597980
99Duplication of thumb phalanx (HP:0009942)1.77222144
100Gastrointestinal atresia (HP:0002589)1.76695381
101Preaxial hand polydactyly (HP:0001177)1.76012195
102Abnormality of glycolysis (HP:0004366)1.75685671
103Increased serum pyruvate (HP:0003542)1.75685671
104Tracheoesophageal fistula (HP:0002575)1.74518366
105Abnormality of the carotid arteries (HP:0005344)1.73585328
106Myelomeningocele (HP:0002475)1.73375837
107Intestinal atresia (HP:0011100)1.72692708
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72663515
109Short thumb (HP:0009778)1.72234612
110Congenital diaphragmatic hernia (HP:0000776)1.72070014
111Absent radius (HP:0003974)1.71751698
112Abnormality of the aortic arch (HP:0012303)1.71171669
113Overlapping toe (HP:0001845)1.70920427
114Supernumerary spleens (HP:0009799)1.70695667
115Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70674358
116Multiple enchondromatosis (HP:0005701)1.70008166
117Optic nerve hypoplasia (HP:0000609)1.69471357
118Optic nerve coloboma (HP:0000588)1.69242085
119Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.68119750
120Bicornuate uterus (HP:0000813)1.67321247
121Premature graying of hair (HP:0002216)1.66816053
122Broad alveolar ridges (HP:0000187)1.66302917
123Hypoplasia of the pons (HP:0012110)1.65506480
124Facial cleft (HP:0002006)1.64958646
125Shawl scrotum (HP:0000049)1.64824249
126Progressive macrocephaly (HP:0004481)1.64158418
127Chronic bronchitis (HP:0004469)1.63977750
128Cellular immunodeficiency (HP:0005374)1.63250195
129Aplasia involving forearm bones (HP:0009822)1.62992044
130Absent forearm bone (HP:0003953)1.62992044
131Depressed nasal ridge (HP:0000457)1.62516587
132Mitochondrial inheritance (HP:0001427)1.62404436
133Abnormality of chromosome segregation (HP:0002916)1.62012444
134Rhabdomyosarcoma (HP:0002859)1.61488620
135Increased CSF lactate (HP:0002490)1.61292400
136Dandy-Walker malformation (HP:0001305)1.60962662
137Secondary amenorrhea (HP:0000869)1.60856629
138Choanal atresia (HP:0000453)1.60530488
139Oligodactyly (hands) (HP:0001180)1.59156157
140Partial duplication of thumb phalanx (HP:0009944)1.57523260
141Cerebral edema (HP:0002181)1.57139220
142Labial hypoplasia (HP:0000066)1.56669431
143Astrocytoma (HP:0009592)1.56612355
144Abnormality of the astrocytes (HP:0100707)1.56612355
145Absent thumb (HP:0009777)1.55162539
146Aplasia/Hypoplasia of the breasts (HP:0010311)1.53526462
147Abnormality of serum amino acid levels (HP:0003112)1.52266167
148Microvesicular hepatic steatosis (HP:0001414)1.51808570
149Renal hypoplasia (HP:0000089)1.51504978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83917008
2CDC74.33563369
3WEE13.75249027
4SRPK13.11011975
5MKNK13.01613844
6EIF2AK13.00560582
7STK163.00553652
8VRK23.00262294
9PBK2.67029030
10DYRK32.64712763
11ACVR1B2.52513526
12NEK22.50412412
13BRSK22.26525295
14MKNK22.19409757
15CCNB12.10920550
16TNIK2.07312002
17BRSK12.01472137
18PLK11.93413633
19TAF11.92500221
20DYRK21.89708797
21PLK41.88426720
22TRIM281.85737897
23MARK11.84267944
24VRK11.83286130
25NEK11.80228669
26PLK31.76032871
27TTK1.72365352
28AURKB1.71383118
29CDK71.67419790
30TSSK61.62620038
31TGFBR11.57208075
32ATR1.55670896
33ERBB31.40575680
34NUAK11.39261798
35CHEK21.37359675
36CDK81.35090278
37MST41.32863357
38EPHB21.31363885
39MAPK131.29200661
40AURKA1.26662628
41PASK1.23907237
42CASK1.21527142
43MAP3K101.17169711
44CHEK11.14164702
45UHMK11.14033861
46RPS6KA41.09314259
47EEF2K1.04721087
48CDK40.97389457
49RPS6KB20.93651530
50TLK10.92467923
51ATM0.90008101
52NME20.88516710
53STK38L0.87282393
54ERBB40.86762267
55PAK40.86054669
56KSR10.86019682
57BRD40.84680499
58CDK20.83729814
59MAP3K40.83417340
60EIF2AK20.82978259
61CDK10.82861826
62ALK0.81534790
63LATS20.79761808
64TESK20.75329980
65EIF2AK30.73901992
66CSNK1G30.72029080
67CDK120.69514957
68ILK0.68035088
69PLK20.66846200
70CSNK2A10.64321921
71MAP2K70.63477030
72MAP3K90.62640705
73YES10.62070331
74MAP3K80.61482992
75FGFR10.60351697
76CDK190.59285810
77ERBB20.59159204
78MINK10.57695777
79LIMK10.57189237
80DYRK1B0.57139331
81PNCK0.56278362
82STK30.55747638
83MELK0.55209463
84CSNK2A20.54877097
85SIK20.54511186
86STK240.53197803
87FGFR20.51615283
88CSNK1A1L0.50584317
89BRAF0.49013909
90BMPR1B0.47683796
91STK40.45563875
92PAK10.45146070
93CSNK1G10.44721623
94SIK30.44158452
95WNK30.43501848
96AKT20.42571649
97EPHA40.41077896
98SMG10.40411044
99MAP3K60.40128192
100CDK60.39294853
101CDK11A0.38674209
102CDK180.38618449
103MAPK90.38584550
104CSNK1E0.38361075
105LATS10.38338823
106DYRK1A0.37932932
107CSNK1G20.37910387
108PRKCI0.37176339
109NME10.36019662
110PRKCG0.35714380
111CDK150.35179569
112RPS6KA10.34081765
113ZAK0.33466475
114PRKDC0.33161547
115CDK140.32682992
116CAMK1G0.32472623
117DAPK10.31689791
118SCYL20.31582838
119MAP4K20.31341089
120CDK30.31066614
121PDK20.30584414
122MAPK140.30147336
123NTRK20.30077795
124BCR0.28718443
125CDK90.28454696
126TAOK20.28036550
127GSK3B0.27976356
128AKT10.27607811
129RPS6KA50.27152237

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.89583719
2Spliceosome_Homo sapiens_hsa030404.09688966
3Mismatch repair_Homo sapiens_hsa034303.84377400
4Ribosome_Homo sapiens_hsa030103.47475740
5Cell cycle_Homo sapiens_hsa041103.42460107
6RNA polymerase_Homo sapiens_hsa030203.27599008
7RNA transport_Homo sapiens_hsa030133.24103657
8Proteasome_Homo sapiens_hsa030503.20095322
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19460236
10Homologous recombination_Homo sapiens_hsa034403.13222798
11Base excision repair_Homo sapiens_hsa034102.95915460
12Nucleotide excision repair_Homo sapiens_hsa034202.81662276
13Pyrimidine metabolism_Homo sapiens_hsa002402.37985823
14mRNA surveillance pathway_Homo sapiens_hsa030152.35648368
15Fanconi anemia pathway_Homo sapiens_hsa034602.33942469
16Basal transcription factors_Homo sapiens_hsa030222.21168004
17RNA degradation_Homo sapiens_hsa030182.08810643
18Non-homologous end-joining_Homo sapiens_hsa034501.76047637
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75950834
20p53 signaling pathway_Homo sapiens_hsa041151.63345500
21Oocyte meiosis_Homo sapiens_hsa041141.62965043
22One carbon pool by folate_Homo sapiens_hsa006701.55740690
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55209783
24Steroid biosynthesis_Homo sapiens_hsa001001.48507076
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44057782
26Pyruvate metabolism_Homo sapiens_hsa006201.35806407
27Purine metabolism_Homo sapiens_hsa002301.30645356
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27079513
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23579784
30Epstein-Barr virus infection_Homo sapiens_hsa051691.18075563
31Basal cell carcinoma_Homo sapiens_hsa052171.15642208
32Parkinsons disease_Homo sapiens_hsa050121.13367842
33Propanoate metabolism_Homo sapiens_hsa006401.12585175
34Huntingtons disease_Homo sapiens_hsa050161.06303535
35Systemic lupus erythematosus_Homo sapiens_hsa053221.06244767
36Hedgehog signaling pathway_Homo sapiens_hsa043401.00358572
37Colorectal cancer_Homo sapiens_hsa052100.92843765
38Hippo signaling pathway_Homo sapiens_hsa043900.89043873
39MicroRNAs in cancer_Homo sapiens_hsa052060.85158236
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84912622
41Viral carcinogenesis_Homo sapiens_hsa052030.81867558
42HTLV-I infection_Homo sapiens_hsa051660.81188281
43Fatty acid elongation_Homo sapiens_hsa000620.81088840
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79900362
45Herpes simplex infection_Homo sapiens_hsa051680.79307379
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77735366
47Small cell lung cancer_Homo sapiens_hsa052220.76634007
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75143260
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74093975
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72638366
51Alcoholism_Homo sapiens_hsa050340.70017466
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69228796
53Notch signaling pathway_Homo sapiens_hsa043300.67772558
54Vitamin B6 metabolism_Homo sapiens_hsa007500.64902434
55Oxidative phosphorylation_Homo sapiens_hsa001900.62985643
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62528277
57Thyroid cancer_Homo sapiens_hsa052160.61545553
58TGF-beta signaling pathway_Homo sapiens_hsa043500.60375861
59Wnt signaling pathway_Homo sapiens_hsa043100.60355973
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57537152
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55593223
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54963076
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52951117
64Viral myocarditis_Homo sapiens_hsa054160.50439027
65Chronic myeloid leukemia_Homo sapiens_hsa052200.50106948
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49815723
67Arginine and proline metabolism_Homo sapiens_hsa003300.49787622
68N-Glycan biosynthesis_Homo sapiens_hsa005100.47716830
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47152342
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.47073589
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45791501
72Endometrial cancer_Homo sapiens_hsa052130.43675410
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43520620
74Pathways in cancer_Homo sapiens_hsa052000.42994079
75Axon guidance_Homo sapiens_hsa043600.41694010
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41512544
77Nicotine addiction_Homo sapiens_hsa050330.40578827
78Butanoate metabolism_Homo sapiens_hsa006500.40122074
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37191992
80Sulfur relay system_Homo sapiens_hsa041220.37163281
81beta-Alanine metabolism_Homo sapiens_hsa004100.36707603
82Alzheimers disease_Homo sapiens_hsa050100.36344014
83Non-small cell lung cancer_Homo sapiens_hsa052230.35417750
84Protein export_Homo sapiens_hsa030600.35221564
85Pentose phosphate pathway_Homo sapiens_hsa000300.34178895
86Biosynthesis of amino acids_Homo sapiens_hsa012300.33645004
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32598633
88Lysine degradation_Homo sapiens_hsa003100.31759119
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30289883
90Hepatitis B_Homo sapiens_hsa051610.30237587
91Fatty acid metabolism_Homo sapiens_hsa012120.29931429
92Phototransduction_Homo sapiens_hsa047440.29350752
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28044566
94Cardiac muscle contraction_Homo sapiens_hsa042600.27679478
95Vitamin digestion and absorption_Homo sapiens_hsa049770.26876754
96Retinol metabolism_Homo sapiens_hsa008300.24231855
97Pancreatic cancer_Homo sapiens_hsa052120.23952854
98Bladder cancer_Homo sapiens_hsa052190.23211456
99FoxO signaling pathway_Homo sapiens_hsa040680.23163925
100Selenocompound metabolism_Homo sapiens_hsa004500.22955975
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.22353988
102Glutathione metabolism_Homo sapiens_hsa004800.22064742
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22028618
104Caffeine metabolism_Homo sapiens_hsa002320.21917887
105Folate biosynthesis_Homo sapiens_hsa007900.21025535
106mTOR signaling pathway_Homo sapiens_hsa041500.19588017
107Prostate cancer_Homo sapiens_hsa052150.18798226
108Antigen processing and presentation_Homo sapiens_hsa046120.18691795
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18408846
110Tryptophan metabolism_Homo sapiens_hsa003800.18193277
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17899873
112Melanoma_Homo sapiens_hsa052180.17580355
113Peroxisome_Homo sapiens_hsa041460.17523449
114Tyrosine metabolism_Homo sapiens_hsa003500.17421166
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17309861
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17077536
117Carbon metabolism_Homo sapiens_hsa012000.14669341
118Apoptosis_Homo sapiens_hsa042100.14406468
119Gap junction_Homo sapiens_hsa045400.14396871
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14257239
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14217544
122AMPK signaling pathway_Homo sapiens_hsa041520.14007265
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13410902
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12759246
125Metabolic pathways_Homo sapiens_hsa011000.12056861
126Adherens junction_Homo sapiens_hsa045200.11756298
127Tight junction_Homo sapiens_hsa045300.11617165
128Renal cell carcinoma_Homo sapiens_hsa052110.09163708
129Melanogenesis_Homo sapiens_hsa049160.07372700
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06134096
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.04994342
132Shigellosis_Homo sapiens_hsa051310.02162755

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