HMGB3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)9.40836262
2ribosomal small subunit biogenesis (GO:0042274)6.70647003
3cell wall macromolecule catabolic process (GO:0016998)6.32933604
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61307778
5ATP synthesis coupled proton transport (GO:0015986)5.47621867
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.47621867
7neuron fate determination (GO:0048664)5.47132998
8cell wall macromolecule metabolic process (GO:0044036)5.30092528
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.28575322
10sequestering of actin monomers (GO:0042989)5.26484236
11kinetochore assembly (GO:0051382)4.93006756
12viral transcription (GO:0019083)4.91943136
13chaperone-mediated protein transport (GO:0072321)4.91607547
14translational termination (GO:0006415)4.79837552
15kinetochore organization (GO:0051383)4.76202723
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.54558445
17behavioral response to nicotine (GO:0035095)4.34208945
18membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.34122475
19ribosomal small subunit assembly (GO:0000028)4.21765685
20epithelial cilium movement (GO:0003351)4.07966400
21cell proliferation in forebrain (GO:0021846)4.06343593
22translational elongation (GO:0006414)3.83579616
23negative regulation of oligodendrocyte differentiation (GO:0048715)3.82138519
24resolution of meiotic recombination intermediates (GO:0000712)3.81753774
25membrane repolarization during action potential (GO:0086011)3.79596469
26cotranslational protein targeting to membrane (GO:0006613)3.76730084
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.75842394
28viral life cycle (GO:0019058)3.75559142
29cellular protein complex disassembly (GO:0043624)3.73810765
30protein targeting to ER (GO:0045047)3.65297632
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57284205
32spinal cord association neuron differentiation (GO:0021527)3.56445061
33regulation of non-canonical Wnt signaling pathway (GO:2000050)3.55760299
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48528405
35respiratory electron transport chain (GO:0022904)3.42958596
36NADH dehydrogenase complex assembly (GO:0010257)3.39056884
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39056884
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.39056884
39electron transport chain (GO:0022900)3.38535333
40protein localization to endoplasmic reticulum (GO:0070972)3.36594492
41neuron fate specification (GO:0048665)3.33499736
42head development (GO:0060322)3.33267836
43chromatin remodeling at centromere (GO:0031055)3.32278645
44protein complex disassembly (GO:0043241)3.31084464
45negative regulation of transcription regulatory region DNA binding (GO:2000678)3.29839091
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28464249
47protein localization to synapse (GO:0035418)3.26815194
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26198584
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26198584
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25731113
51retinal ganglion cell axon guidance (GO:0031290)3.24936146
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24406913
53cellular potassium ion homeostasis (GO:0030007)3.24353212
54positive regulation of mitochondrial fission (GO:0090141)3.22576703
55otic vesicle formation (GO:0030916)3.22413555
56macromolecular complex disassembly (GO:0032984)3.22400716
57protein neddylation (GO:0045116)3.21621705
58limb development (GO:0060173)3.20952839
59appendage development (GO:0048736)3.20952839
60CENP-A containing nucleosome assembly (GO:0034080)3.19848793
61presynaptic membrane assembly (GO:0097105)3.17694294
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17187465
63regulation of skeletal muscle contraction (GO:0014819)3.15304558
64ATP biosynthetic process (GO:0006754)3.12391361
65pyrimidine nucleobase catabolic process (GO:0006208)3.11641041
66positive regulation of synapse maturation (GO:0090129)3.11079404
67translational initiation (GO:0006413)3.09628705
68protein complex biogenesis (GO:0070271)3.07852670
69regulation of appetite (GO:0032098)3.04715314
70membrane repolarization (GO:0086009)3.04543997
71nonmotile primary cilium assembly (GO:0035058)2.98994892
72forebrain neuron differentiation (GO:0021879)2.94687631
73establishment of mitotic spindle localization (GO:0040001)2.93441618
74nuclear-transcribed mRNA catabolic process (GO:0000956)2.92394534
75cilium movement (GO:0003341)2.92370189
76positive regulation of potassium ion transmembrane transport (GO:1901381)2.89422288
77regulation of synapse maturation (GO:0090128)2.88041786
78dentate gyrus development (GO:0021542)2.83978476
79postsynaptic membrane organization (GO:0001941)2.83315953
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81197792
81substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79552003
82substrate-independent telencephalic tangential migration (GO:0021826)2.79552003
83inner mitochondrial membrane organization (GO:0007007)2.78569467
84mRNA catabolic process (GO:0006402)2.77450331
85establishment of mitotic spindle orientation (GO:0000132)2.76664881
86neuronal stem cell maintenance (GO:0097150)2.72512294
87presynaptic membrane organization (GO:0097090)2.71487495
88mitochondrial respiratory chain complex assembly (GO:0033108)2.70544408
89pyrimidine-containing compound transmembrane transport (GO:0072531)2.69760487
90response to electrical stimulus (GO:0051602)2.69076081
91somite development (GO:0061053)2.68300398
92kidney morphogenesis (GO:0060993)2.67320366
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66518411
94ribosomal large subunit biogenesis (GO:0042273)2.66500499
95cell differentiation in spinal cord (GO:0021515)2.64911118
96neuron cell-cell adhesion (GO:0007158)2.61523011
97viral protein processing (GO:0019082)2.60915556
98protein localization to cilium (GO:0061512)2.58981773
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.55666852
100lipopolysaccharide biosynthetic process (GO:0009103)2.55577183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.11437617
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76354187
3EZH2_22144423_ChIP-Seq_EOC_Human3.69723364
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.63774514
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.95485017
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.63551125
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59604225
8VDR_22108803_ChIP-Seq_LS180_Human2.57750983
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.39242257
10EWS_26573619_Chip-Seq_HEK293_Human2.17276217
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15787185
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.11918924
13IRF1_19129219_ChIP-ChIP_H3396_Human2.11598740
14ZNF274_21170338_ChIP-Seq_K562_Hela2.09992369
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08899119
16RNF2_27304074_Chip-Seq_NSC_Mouse2.06795134
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.05963106
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96849451
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89079594
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.88646358
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84337519
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79246681
23TTF2_22483619_ChIP-Seq_HELA_Human1.76956139
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76441750
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70839337
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70170561
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69063614
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.67051741
29XRN2_22483619_ChIP-Seq_HELA_Human1.60321890
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59134269
31REST_21632747_ChIP-Seq_MESCs_Mouse1.58327572
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57854946
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55570912
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.55390833
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54738921
36TAF15_26573619_Chip-Seq_HEK293_Human1.51853144
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46015379
38FUS_26573619_Chip-Seq_HEK293_Human1.45730990
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43047346
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43047346
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42856775
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42617250
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35696150
44ELK1_19687146_ChIP-ChIP_HELA_Human1.34923579
45MYC_18940864_ChIP-ChIP_HL60_Human1.34617654
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34004053
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.32933278
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31815578
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31708046
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.30317291
51IGF1R_20145208_ChIP-Seq_DFB_Human1.29262181
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27542066
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27243836
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26037430
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25637163
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.25591476
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22288184
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21871965
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21635432
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17795848
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17722617
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17722617
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17497545
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16181762
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15884765
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15503341
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13121452
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12807132
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.11604324
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11200441
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10812562
72GABP_19822575_ChIP-Seq_HepG2_Human1.09423093
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.08756317
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.08459320
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05255650
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03770329
77FOXP3_21729870_ChIP-Seq_TREG_Human1.03247738
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02513297
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01276226
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00925485
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99137010
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99078097
83TP53_22573176_ChIP-Seq_HFKS_Human0.98372487
84ERA_21632823_ChIP-Seq_H3396_Human0.97471628
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90575615
86RING1B_27294783_Chip-Seq_ESCs_Mouse0.90067819
87VDR_23849224_ChIP-Seq_CD4+_Human0.88636472
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88003708
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87678790
90P300_19829295_ChIP-Seq_ESCs_Human0.87566260
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.87275144
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86522450
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.86191259
94CBP_20019798_ChIP-Seq_JUKART_Human0.86086709
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86086709
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85047767
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84110003
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83800812
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.83213963
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81147137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.80379571
2MP0003122_maternal_imprinting4.49721595
3MP0006292_abnormal_olfactory_placode4.27399748
4MP0000566_synostosis3.53392907
5MP0003880_abnormal_central_pattern2.98255981
6MP0002653_abnormal_ependyma_morphology2.84517648
7MP0003121_genomic_imprinting2.57119945
8MP0003646_muscle_fatigue2.38772872
9MP0002234_abnormal_pharynx_morphology2.28315172
10MP0002102_abnormal_ear_morphology2.22309578
11MP0000631_abnormal_neuroendocrine_gland2.18646497
12MP0004142_abnormal_muscle_tone2.17989928
13MP0004133_heterotaxia2.15291430
14MP0001293_anophthalmia2.02518738
15MP0000049_abnormal_middle_ear2.02061016
16MP0008789_abnormal_olfactory_epithelium2.00246716
17MP0002938_white_spotting1.98222591
18MP0002837_dystrophic_cardiac_calcinosis1.91657372
19MP0003123_paternal_imprinting1.86565670
20MP0000778_abnormal_nervous_system1.85247197
21MP0003937_abnormal_limbs/digits/tail_de1.81955022
22MP0000372_irregular_coat_pigmentation1.80956586
23MP0003136_yellow_coat_color1.77190205
24MP0008961_abnormal_basal_metabolism1.75928710
25MP0005394_taste/olfaction_phenotype1.68462177
26MP0005499_abnormal_olfactory_system1.68462177
27MP0006276_abnormal_autonomic_nervous1.62100420
28MP0001502_abnormal_circadian_rhythm1.58206518
29MP0003755_abnormal_palate_morphology1.56787609
30MP0001485_abnormal_pinna_reflex1.52241982
31MP0003938_abnormal_ear_development1.51541363
32MP0003787_abnormal_imprinting1.50848643
33MP0000537_abnormal_urethra_morphology1.42103275
34MP0000026_abnormal_inner_ear1.41031698
35MP0002249_abnormal_larynx_morphology1.40319877
36MP0004742_abnormal_vestibular_system1.31044655
37MP0009745_abnormal_behavioral_response1.23868703
38MP0004215_abnormal_myocardial_fiber1.22485832
39MP0000955_abnormal_spinal_cord1.22001781
40MP0002697_abnormal_eye_size1.17735033
41MP0002233_abnormal_nose_morphology1.17493319
42MP0010030_abnormal_orbit_morphology1.16562440
43MP0008877_abnormal_DNA_methylation1.14920071
44MP0003693_abnormal_embryo_hatching1.14186776
45MP0001440_abnormal_grooming_behavior1.13836278
46MP0001348_abnormal_lacrimal_gland1.11729481
47MP0002272_abnormal_nervous_system1.11720867
48MP0002095_abnormal_skin_pigmentation1.09209969
49MP0005645_abnormal_hypothalamus_physiol1.08538225
50MP0002163_abnormal_gland_morphology1.07533527
51MP0002557_abnormal_social/conspecific_i1.06693763
52MP0003959_abnormal_lean_body1.06433630
53MP0001286_abnormal_eye_development1.05401226
54MP0003861_abnormal_nervous_system1.03790555
55MP0002752_abnormal_somatic_nervous1.03025440
56MP0009046_muscle_twitch1.01483928
57MP0002928_abnormal_bile_duct1.00422956
58MP0005551_abnormal_eye_electrophysiolog0.99760591
59MP0001486_abnormal_startle_reflex0.98120072
60MP0002736_abnormal_nociception_after0.97952295
61MP0008058_abnormal_DNA_repair0.97460814
62MP0003635_abnormal_synaptic_transmissio0.97116171
63MP0001963_abnormal_hearing_physiology0.97064739
64MP0002152_abnormal_brain_morphology0.96854123
65MP0002184_abnormal_innervation0.94308790
66MP0002064_seizures0.94049916
67MP0002116_abnormal_craniofacial_bone0.92399578
68MP0005195_abnormal_posterior_eye0.92178787
69MP0001188_hyperpigmentation0.91521188
70MP0001968_abnormal_touch/_nociception0.88954442
71MP0005423_abnormal_somatic_nervous0.87688521
72MP0002063_abnormal_learning/memory/cond0.87620482
73MP0008872_abnormal_physiological_respon0.86995253
74MP0002638_abnormal_pupillary_reflex0.86970859
75MP0002882_abnormal_neuron_morphology0.85770383
76MP0001986_abnormal_taste_sensitivity0.85763711
77MP0003718_maternal_effect0.85707052
78MP0001529_abnormal_vocalization0.85437166
79MP0004859_abnormal_synaptic_plasticity0.84651724
80MP0000427_abnormal_hair_cycle0.84073806
81MP0001984_abnormal_olfaction0.81664294
82MP0002109_abnormal_limb_morphology0.80660702
83MP0009250_abnormal_appendicular_skeleto0.80658102
84MP0005448_abnormal_energy_balance0.80453128
85MP0005174_abnormal_tail_pigmentation0.79324237
86MP0002067_abnormal_sensory_capabilities0.76750586
87MP0006072_abnormal_retinal_apoptosis0.76510331
88MP0002572_abnormal_emotion/affect_behav0.75029498
89MP0002092_abnormal_eye_morphology0.72202972
90MP0005391_vision/eye_phenotype0.71746679
91MP0005083_abnormal_biliary_tract0.71723314
92MP0005084_abnormal_gallbladder_morpholo0.71714921
93MP0001270_distended_abdomen0.69836696
94MP0002177_abnormal_outer_ear0.68183820
95MP0003567_abnormal_fetal_cardiomyocyte0.67018498
96MP0006035_abnormal_mitochondrial_morpho0.66293245
97MP0001970_abnormal_pain_threshold0.65970194
98MP0004811_abnormal_neuron_physiology0.64225356
99MP0005253_abnormal_eye_physiology0.63440803
100MP0002751_abnormal_autonomic_nervous0.63345639

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.08473708
2Partial duplication of thumb phalanx (HP:0009944)5.49425704
3Partial duplication of the phalanx of hand (HP:0009999)4.88207396
4Abnormality of midbrain morphology (HP:0002418)4.39986715
5Molar tooth sign on MRI (HP:0002419)4.39986715
6Retinal dysplasia (HP:0007973)3.20196119
7Duplication of thumb phalanx (HP:0009942)3.13213150
8Septo-optic dysplasia (HP:0100842)3.08047423
9Medial flaring of the eyebrow (HP:0010747)3.06998782
10Myokymia (HP:0002411)3.05649278
11Chronic hepatic failure (HP:0100626)2.97520006
12Abnormality of the phalanges of the hallux (HP:0010057)2.92241292
13Aplasia/Hypoplasia of the sacrum (HP:0008517)2.91483578
14Hyperglycinemia (HP:0002154)2.87790165
15Nephrogenic diabetes insipidus (HP:0009806)2.74017672
16Acute necrotizing encephalopathy (HP:0006965)2.73884578
17Nephronophthisis (HP:0000090)2.69269629
1811 pairs of ribs (HP:0000878)2.67432262
19Acute encephalopathy (HP:0006846)2.66854678
20Gait imbalance (HP:0002141)2.65896481
21Sclerocornea (HP:0000647)2.62260091
22Stenosis of the external auditory canal (HP:0000402)2.58789314
23Pancreatic fibrosis (HP:0100732)2.57970716
24Abnormality of cells of the erythroid lineage (HP:0012130)2.54383918
25Congenital primary aphakia (HP:0007707)2.54113579
26Increased hepatocellular lipid droplets (HP:0006565)2.53947262
27Abnormality of renal resorption (HP:0011038)2.52684219
28Abnormal mitochondria in muscle tissue (HP:0008316)2.50584117
29Abnormality of the labia minora (HP:0012880)2.49904530
30Abnormal tarsal ossification (HP:0008369)2.46995882
31Persistence of primary teeth (HP:0006335)2.46348363
32Anencephaly (HP:0002323)2.46211072
33Pendular nystagmus (HP:0012043)2.43721793
34Type II lissencephaly (HP:0007260)2.43209657
35Macrocytic anemia (HP:0001972)2.38251293
36Hypoplasia of the pons (HP:0012110)2.37251406
37Anophthalmia (HP:0000528)2.35963838
38Bifid tongue (HP:0010297)2.33775954
393-Methylglutaconic aciduria (HP:0003535)2.33428940
40Mitochondrial inheritance (HP:0001427)2.31703400
41Vaginal atresia (HP:0000148)2.30413916
42Abnormality of the parietal bone (HP:0002696)2.30189635
43Hyperglycinuria (HP:0003108)2.25333314
44Abnormal hemoglobin (HP:0011902)2.25295665
45Genital tract atresia (HP:0001827)2.24873023
46Lipid accumulation in hepatocytes (HP:0006561)2.23962065
47Agitation (HP:0000713)2.18542576
48Absent septum pellucidum (HP:0001331)2.18537570
49Renal Fanconi syndrome (HP:0001994)2.17021046
50Progressive macrocephaly (HP:0004481)2.16780302
51Abnormality of the renal medulla (HP:0100957)2.15855776
52Degeneration of anterior horn cells (HP:0002398)2.12980952
53Abnormality of the anterior horn cell (HP:0006802)2.12980952
54Colon cancer (HP:0003003)2.12693705
55Microretrognathia (HP:0000308)2.11821015
56Increased intramyocellular lipid droplets (HP:0012240)2.08622919
57Lissencephaly (HP:0001339)2.07982583
58Synostosis involving the elbow (HP:0003938)2.07553746
59Humeroradial synostosis (HP:0003041)2.07553746
60Focal motor seizures (HP:0011153)2.06217070
61Small hand (HP:0200055)2.05803461
62Limb dystonia (HP:0002451)2.05003653
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04373235
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04373235
65Sleep apnea (HP:0010535)2.03923264
66Abnormal respiratory epithelium morphology (HP:0012253)2.03125472
67Abnormal respiratory motile cilium morphology (HP:0005938)2.03125472
68Increased CSF lactate (HP:0002490)2.02176537
69Poor coordination (HP:0002370)2.01972829
70Pancreatic cysts (HP:0001737)2.01329951
71Osteomalacia (HP:0002749)2.01083888
72Congenital stationary night blindness (HP:0007642)2.00045214
73Abnormality of the pons (HP:0007361)1.98790869
74Postaxial foot polydactyly (HP:0001830)1.97270952
75Broad distal phalanx of finger (HP:0009836)1.93534607
76Holoprosencephaly (HP:0001360)1.93485847
77Symphalangism affecting the phalanges of the hand (HP:0009773)1.92863121
78Pallor (HP:0000980)1.91807762
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90301919
80Rectovaginal fistula (HP:0000143)1.87868241
81Rectal fistula (HP:0100590)1.87868241
82Abnormality of the aortic arch (HP:0012303)1.87637996
83Cerebellar dysplasia (HP:0007033)1.87201380
84Esotropia (HP:0000565)1.84310192
85Abnormality of abdominal situs (HP:0011620)1.83387265
86Abdominal situs inversus (HP:0003363)1.83387265
87Intellectual disability, moderate (HP:0002342)1.82986969
88Hypoplasia of the radius (HP:0002984)1.82678043
89Polyphagia (HP:0002591)1.82521034
90Postaxial hand polydactyly (HP:0001162)1.81573955
91Hepatocellular necrosis (HP:0001404)1.80750149
92Abnormal urine phosphate concentration (HP:0012599)1.78944833
93Abnormality of reticulocytes (HP:0004312)1.77939358
94Limb hypertonia (HP:0002509)1.75986723
95Overriding aorta (HP:0002623)1.75002454
96Specific learning disability (HP:0001328)1.73680130
97True hermaphroditism (HP:0010459)1.71585986
98Hip dysplasia (HP:0001385)1.71547174
99Oculomotor apraxia (HP:0000657)1.70650280
100Esophageal atresia (HP:0002032)1.69600382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.27048103
2GRK73.62485779
3ZAK3.47248612
4BUB13.30873269
5CDC72.79819630
6STK32.34571328
7UHMK12.29148034
8NEK22.12212136
9PINK12.08810318
10MAP3K42.06468041
11PLK42.04650480
12EPHA41.90921309
13NUAK11.86205001
14MARK21.79740877
15MAP2K71.76577822
16WNK31.75895551
17MAP4K21.71557495
18FGFR21.66636966
19ADRBK21.66115608
20SRPK11.64566459
21RPS6KA41.57576742
22TNIK1.55433482
23BCKDK1.43684529
24PLK21.42887954
25STK241.39967240
26BRAF1.39366463
27AURKA1.37204688
28MARK11.34496442
29DYRK21.34093801
30MAP2K41.29360886
31TYRO31.26575429
32VRK11.26061967
33CHEK21.24239600
34FRK1.19923044
35PLK31.16814850
36AKT31.14034299
37CAMK11.11366381
38PLK11.11344904
39DYRK31.11311573
40BCR1.09696840
41GRK11.05771117
42BRSK11.02952821
43PRKCG1.00913582
44CSNK1G20.99839908
45ADRBK10.96469871
46EPHB20.95110967
47SGK2230.94802549
48SGK4940.94802549
49PIK3CA0.93128036
50MAP3K110.92002349
51LATS10.86211750
52AURKB0.85304245
53PBK0.85081926
54MAP3K120.84578726
55CAMK40.81925535
56TTK0.80657662
57PDK20.77499920
58MAPK150.76947941
59MAP3K90.74889936
60SGK20.74810801
61WEE10.74810589
62WNK40.74133305
63PNCK0.71488976
64MKNK20.71162779
65ARAF0.65091435
66CSNK1G30.64608778
67PRKACA0.64099253
68NME10.63950733
69MINK10.60087107
70TIE10.59792661
71PRKCE0.59086839
72NEK10.58973485
73PRKCI0.58763450
74CSNK1G10.58696264
75IRAK10.58015126
76MKNK10.55797352
77CSNK2A20.54509046
78PAK30.53774562
79DYRK1B0.51245227
80SIK20.49981416
81CAMKK20.47560878
82CSNK1E0.42701761
83CAMK2A0.41658499
84CSNK1A1L0.41578946
85DYRK1A0.40653273
86MAP3K50.40571952
87CDK30.40424623
88INSRR0.39491114
89VRK20.37810827
90ERBB20.36824687
91STK390.36068306
92MAPK130.35921416
93CDK190.35090166
94PRKCA0.34728967
95PHKG10.34726209
96PHKG20.34726209
97CSNK1A10.33331236
98RPS6KA60.33113705
99CSNK2A10.32978908
100PKN10.31117301

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.24046523
2Oxidative phosphorylation_Homo sapiens_hsa001904.70157188
3Parkinsons disease_Homo sapiens_hsa050123.93977577
4Huntingtons disease_Homo sapiens_hsa050163.12479506
5Cardiac muscle contraction_Homo sapiens_hsa042602.79484193
6Alzheimers disease_Homo sapiens_hsa050102.60446800
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24522350
8RNA polymerase_Homo sapiens_hsa030202.18593359
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12110257
10RNA degradation_Homo sapiens_hsa030182.10626613
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99185479
12Fanconi anemia pathway_Homo sapiens_hsa034601.98013184
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87489789
14Spliceosome_Homo sapiens_hsa030401.84873512
15Proteasome_Homo sapiens_hsa030501.76438500
16Phototransduction_Homo sapiens_hsa047441.72080682
17Nicotine addiction_Homo sapiens_hsa050331.62214966
18Propanoate metabolism_Homo sapiens_hsa006401.56347968
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51016515
20Fatty acid elongation_Homo sapiens_hsa000621.50930714
21Non-homologous end-joining_Homo sapiens_hsa034501.50542880
22Serotonergic synapse_Homo sapiens_hsa047261.46864850
23Morphine addiction_Homo sapiens_hsa050321.45359763
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44642317
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36950186
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33372855
27Hippo signaling pathway_Homo sapiens_hsa043901.31098492
28Dopaminergic synapse_Homo sapiens_hsa047281.30509428
29Cholinergic synapse_Homo sapiens_hsa047251.25709301
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22071686
31Glutamatergic synapse_Homo sapiens_hsa047241.21190953
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15401419
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12727685
34Basal cell carcinoma_Homo sapiens_hsa052171.08583059
35Pyruvate metabolism_Homo sapiens_hsa006201.07527655
36RNA transport_Homo sapiens_hsa030131.07511608
37Circadian entrainment_Homo sapiens_hsa047130.99523606
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96206750
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92867305
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91954158
41Selenocompound metabolism_Homo sapiens_hsa004500.90065433
42Homologous recombination_Homo sapiens_hsa034400.84383490
43mRNA surveillance pathway_Homo sapiens_hsa030150.83332258
44Melanoma_Homo sapiens_hsa052180.81132178
45Protein export_Homo sapiens_hsa030600.80369618
46Cocaine addiction_Homo sapiens_hsa050300.79026848
47Purine metabolism_Homo sapiens_hsa002300.78510326
48Pyrimidine metabolism_Homo sapiens_hsa002400.74819408
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.74744110
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71403339
51Linoleic acid metabolism_Homo sapiens_hsa005910.69842450
52Olfactory transduction_Homo sapiens_hsa047400.69817293
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.66696098
54Metabolic pathways_Homo sapiens_hsa011000.64271075
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62742620
56GABAergic synapse_Homo sapiens_hsa047270.62732384
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62637975
58Fatty acid biosynthesis_Homo sapiens_hsa000610.62575370
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.62088572
60Base excision repair_Homo sapiens_hsa034100.60980816
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59550163
62Oxytocin signaling pathway_Homo sapiens_hsa049210.59183699
63Mismatch repair_Homo sapiens_hsa034300.58100746
64Notch signaling pathway_Homo sapiens_hsa043300.56891224
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56792726
66Basal transcription factors_Homo sapiens_hsa030220.56150011
67Oocyte meiosis_Homo sapiens_hsa041140.55613961
68Hedgehog signaling pathway_Homo sapiens_hsa043400.54173799
69Butanoate metabolism_Homo sapiens_hsa006500.53675803
70Cell cycle_Homo sapiens_hsa041100.53327335
71Retinol metabolism_Homo sapiens_hsa008300.53225071
72Chemical carcinogenesis_Homo sapiens_hsa052040.53075636
73Regulation of autophagy_Homo sapiens_hsa041400.49172773
74Peroxisome_Homo sapiens_hsa041460.48756384
75Tyrosine metabolism_Homo sapiens_hsa003500.47644416
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.47538134
77Wnt signaling pathway_Homo sapiens_hsa043100.45544452
78Axon guidance_Homo sapiens_hsa043600.42860941
79One carbon pool by folate_Homo sapiens_hsa006700.41156715
80Long-term depression_Homo sapiens_hsa047300.40639654
81Ovarian steroidogenesis_Homo sapiens_hsa049130.40132361
82Insulin secretion_Homo sapiens_hsa049110.39393435
83Sulfur relay system_Homo sapiens_hsa041220.35929186
84DNA replication_Homo sapiens_hsa030300.35660758
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35266397
86Collecting duct acid secretion_Homo sapiens_hsa049660.35259362
87Taste transduction_Homo sapiens_hsa047420.35222032
88Synaptic vesicle cycle_Homo sapiens_hsa047210.35134182
89p53 signaling pathway_Homo sapiens_hsa041150.33897048
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33790866
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33148538
92Amphetamine addiction_Homo sapiens_hsa050310.33003294
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32500218
94Renin secretion_Homo sapiens_hsa049240.31474701
95Phenylalanine metabolism_Homo sapiens_hsa003600.28296311
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28055944
97Rap1 signaling pathway_Homo sapiens_hsa040150.26299562
98Nitrogen metabolism_Homo sapiens_hsa009100.26032778
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24803460
100Nucleotide excision repair_Homo sapiens_hsa034200.24083653

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