

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | maturation of SSU-rRNA (GO:0030490) | 9.40836262 |
| 2 | ribosomal small subunit biogenesis (GO:0042274) | 6.70647003 |
| 3 | cell wall macromolecule catabolic process (GO:0016998) | 6.32933604 |
| 4 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.61307778 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 5.47621867 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.47621867 |
| 7 | neuron fate determination (GO:0048664) | 5.47132998 |
| 8 | cell wall macromolecule metabolic process (GO:0044036) | 5.30092528 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.28575322 |
| 10 | sequestering of actin monomers (GO:0042989) | 5.26484236 |
| 11 | kinetochore assembly (GO:0051382) | 4.93006756 |
| 12 | viral transcription (GO:0019083) | 4.91943136 |
| 13 | chaperone-mediated protein transport (GO:0072321) | 4.91607547 |
| 14 | translational termination (GO:0006415) | 4.79837552 |
| 15 | kinetochore organization (GO:0051383) | 4.76202723 |
| 16 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.54558445 |
| 17 | behavioral response to nicotine (GO:0035095) | 4.34208945 |
| 18 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 4.34122475 |
| 19 | ribosomal small subunit assembly (GO:0000028) | 4.21765685 |
| 20 | epithelial cilium movement (GO:0003351) | 4.07966400 |
| 21 | cell proliferation in forebrain (GO:0021846) | 4.06343593 |
| 22 | translational elongation (GO:0006414) | 3.83579616 |
| 23 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 3.82138519 |
| 24 | resolution of meiotic recombination intermediates (GO:0000712) | 3.81753774 |
| 25 | membrane repolarization during action potential (GO:0086011) | 3.79596469 |
| 26 | cotranslational protein targeting to membrane (GO:0006613) | 3.76730084 |
| 27 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.75842394 |
| 28 | viral life cycle (GO:0019058) | 3.75559142 |
| 29 | cellular protein complex disassembly (GO:0043624) | 3.73810765 |
| 30 | protein targeting to ER (GO:0045047) | 3.65297632 |
| 31 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.57284205 |
| 32 | spinal cord association neuron differentiation (GO:0021527) | 3.56445061 |
| 33 | regulation of non-canonical Wnt signaling pathway (GO:2000050) | 3.55760299 |
| 34 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.48528405 |
| 35 | respiratory electron transport chain (GO:0022904) | 3.42958596 |
| 36 | NADH dehydrogenase complex assembly (GO:0010257) | 3.39056884 |
| 37 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.39056884 |
| 38 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.39056884 |
| 39 | electron transport chain (GO:0022900) | 3.38535333 |
| 40 | protein localization to endoplasmic reticulum (GO:0070972) | 3.36594492 |
| 41 | neuron fate specification (GO:0048665) | 3.33499736 |
| 42 | head development (GO:0060322) | 3.33267836 |
| 43 | chromatin remodeling at centromere (GO:0031055) | 3.32278645 |
| 44 | protein complex disassembly (GO:0043241) | 3.31084464 |
| 45 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 3.29839091 |
| 46 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.28464249 |
| 47 | protein localization to synapse (GO:0035418) | 3.26815194 |
| 48 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.26198584 |
| 49 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.26198584 |
| 50 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.25731113 |
| 51 | retinal ganglion cell axon guidance (GO:0031290) | 3.24936146 |
| 52 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.24406913 |
| 53 | cellular potassium ion homeostasis (GO:0030007) | 3.24353212 |
| 54 | positive regulation of mitochondrial fission (GO:0090141) | 3.22576703 |
| 55 | otic vesicle formation (GO:0030916) | 3.22413555 |
| 56 | macromolecular complex disassembly (GO:0032984) | 3.22400716 |
| 57 | protein neddylation (GO:0045116) | 3.21621705 |
| 58 | limb development (GO:0060173) | 3.20952839 |
| 59 | appendage development (GO:0048736) | 3.20952839 |
| 60 | CENP-A containing nucleosome assembly (GO:0034080) | 3.19848793 |
| 61 | presynaptic membrane assembly (GO:0097105) | 3.17694294 |
| 62 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.17187465 |
| 63 | regulation of skeletal muscle contraction (GO:0014819) | 3.15304558 |
| 64 | ATP biosynthetic process (GO:0006754) | 3.12391361 |
| 65 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.11641041 |
| 66 | positive regulation of synapse maturation (GO:0090129) | 3.11079404 |
| 67 | translational initiation (GO:0006413) | 3.09628705 |
| 68 | protein complex biogenesis (GO:0070271) | 3.07852670 |
| 69 | regulation of appetite (GO:0032098) | 3.04715314 |
| 70 | membrane repolarization (GO:0086009) | 3.04543997 |
| 71 | nonmotile primary cilium assembly (GO:0035058) | 2.98994892 |
| 72 | forebrain neuron differentiation (GO:0021879) | 2.94687631 |
| 73 | establishment of mitotic spindle localization (GO:0040001) | 2.93441618 |
| 74 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.92394534 |
| 75 | cilium movement (GO:0003341) | 2.92370189 |
| 76 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.89422288 |
| 77 | regulation of synapse maturation (GO:0090128) | 2.88041786 |
| 78 | dentate gyrus development (GO:0021542) | 2.83978476 |
| 79 | postsynaptic membrane organization (GO:0001941) | 2.83315953 |
| 80 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.81197792 |
| 81 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.79552003 |
| 82 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.79552003 |
| 83 | inner mitochondrial membrane organization (GO:0007007) | 2.78569467 |
| 84 | mRNA catabolic process (GO:0006402) | 2.77450331 |
| 85 | establishment of mitotic spindle orientation (GO:0000132) | 2.76664881 |
| 86 | neuronal stem cell maintenance (GO:0097150) | 2.72512294 |
| 87 | presynaptic membrane organization (GO:0097090) | 2.71487495 |
| 88 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.70544408 |
| 89 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 2.69760487 |
| 90 | response to electrical stimulus (GO:0051602) | 2.69076081 |
| 91 | somite development (GO:0061053) | 2.68300398 |
| 92 | kidney morphogenesis (GO:0060993) | 2.67320366 |
| 93 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.66518411 |
| 94 | ribosomal large subunit biogenesis (GO:0042273) | 2.66500499 |
| 95 | cell differentiation in spinal cord (GO:0021515) | 2.64911118 |
| 96 | neuron cell-cell adhesion (GO:0007158) | 2.61523011 |
| 97 | viral protein processing (GO:0019082) | 2.60915556 |
| 98 | protein localization to cilium (GO:0061512) | 2.58981773 |
| 99 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.55666852 |
| 100 | lipopolysaccharide biosynthetic process (GO:0009103) | 2.55577183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 6.11437617 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.76354187 |
| 3 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.69723364 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.63774514 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.95485017 |
| 6 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.63551125 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.59604225 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.57750983 |
| 9 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.39242257 |
| 10 | EWS_26573619_Chip-Seq_HEK293_Human | 2.17276217 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.15787185 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.11918924 |
| 13 | IRF1_19129219_ChIP-ChIP_H3396_Human | 2.11598740 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.09992369 |
| 15 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.08899119 |
| 16 | RNF2_27304074_Chip-Seq_NSC_Mouse | 2.06795134 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.05963106 |
| 18 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.96849451 |
| 19 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.89079594 |
| 20 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.88646358 |
| 21 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.84337519 |
| 22 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.79246681 |
| 23 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.76956139 |
| 24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.76441750 |
| 25 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.70839337 |
| 26 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.70170561 |
| 27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.69063614 |
| 28 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.67051741 |
| 29 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.60321890 |
| 30 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.59134269 |
| 31 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.58327572 |
| 32 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.57854946 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.55570912 |
| 34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.55390833 |
| 35 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.54738921 |
| 36 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.51853144 |
| 37 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.46015379 |
| 38 | FUS_26573619_Chip-Seq_HEK293_Human | 1.45730990 |
| 39 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.43047346 |
| 40 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.43047346 |
| 41 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.42856775 |
| 42 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.42617250 |
| 43 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.35696150 |
| 44 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.34923579 |
| 45 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.34617654 |
| 46 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.34004053 |
| 47 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.32933278 |
| 48 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.31815578 |
| 49 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.31708046 |
| 50 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.30317291 |
| 51 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.29262181 |
| 52 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.27542066 |
| 53 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.27243836 |
| 54 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.26037430 |
| 55 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.25637163 |
| 56 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.25591476 |
| 57 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.22288184 |
| 58 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.21871965 |
| 59 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.21635432 |
| 60 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.17795848 |
| 61 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.17722617 |
| 62 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17722617 |
| 63 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.17497545 |
| 64 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.16181762 |
| 65 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.15884765 |
| 66 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.15503341 |
| 67 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.13121452 |
| 68 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.12807132 |
| 69 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.11604324 |
| 70 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.11200441 |
| 71 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.10812562 |
| 72 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.09423093 |
| 73 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.08756317 |
| 74 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.08459320 |
| 75 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.05255650 |
| 76 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.03770329 |
| 77 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.03247738 |
| 78 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.02513297 |
| 79 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.01276226 |
| 80 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.00925485 |
| 81 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.99137010 |
| 82 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.99078097 |
| 83 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.98372487 |
| 84 | ERA_21632823_ChIP-Seq_H3396_Human | 0.97471628 |
| 85 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.90575615 |
| 86 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.90067819 |
| 87 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.88636472 |
| 88 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.88003708 |
| 89 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.87678790 |
| 90 | P300_19829295_ChIP-Seq_ESCs_Human | 0.87566260 |
| 91 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.87275144 |
| 92 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.86522450 |
| 93 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.86191259 |
| 94 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.86086709 |
| 95 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.86086709 |
| 96 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.85047767 |
| 97 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.84110003 |
| 98 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.83800812 |
| 99 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.83213963 |
| 100 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.81147137 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 5.80379571 |
| 2 | MP0003122_maternal_imprinting | 4.49721595 |
| 3 | MP0006292_abnormal_olfactory_placode | 4.27399748 |
| 4 | MP0000566_synostosis | 3.53392907 |
| 5 | MP0003880_abnormal_central_pattern | 2.98255981 |
| 6 | MP0002653_abnormal_ependyma_morphology | 2.84517648 |
| 7 | MP0003121_genomic_imprinting | 2.57119945 |
| 8 | MP0003646_muscle_fatigue | 2.38772872 |
| 9 | MP0002234_abnormal_pharynx_morphology | 2.28315172 |
| 10 | MP0002102_abnormal_ear_morphology | 2.22309578 |
| 11 | MP0000631_abnormal_neuroendocrine_gland | 2.18646497 |
| 12 | MP0004142_abnormal_muscle_tone | 2.17989928 |
| 13 | MP0004133_heterotaxia | 2.15291430 |
| 14 | MP0001293_anophthalmia | 2.02518738 |
| 15 | MP0000049_abnormal_middle_ear | 2.02061016 |
| 16 | MP0008789_abnormal_olfactory_epithelium | 2.00246716 |
| 17 | MP0002938_white_spotting | 1.98222591 |
| 18 | MP0002837_dystrophic_cardiac_calcinosis | 1.91657372 |
| 19 | MP0003123_paternal_imprinting | 1.86565670 |
| 20 | MP0000778_abnormal_nervous_system | 1.85247197 |
| 21 | MP0003937_abnormal_limbs/digits/tail_de | 1.81955022 |
| 22 | MP0000372_irregular_coat_pigmentation | 1.80956586 |
| 23 | MP0003136_yellow_coat_color | 1.77190205 |
| 24 | MP0008961_abnormal_basal_metabolism | 1.75928710 |
| 25 | MP0005394_taste/olfaction_phenotype | 1.68462177 |
| 26 | MP0005499_abnormal_olfactory_system | 1.68462177 |
| 27 | MP0006276_abnormal_autonomic_nervous | 1.62100420 |
| 28 | MP0001502_abnormal_circadian_rhythm | 1.58206518 |
| 29 | MP0003755_abnormal_palate_morphology | 1.56787609 |
| 30 | MP0001485_abnormal_pinna_reflex | 1.52241982 |
| 31 | MP0003938_abnormal_ear_development | 1.51541363 |
| 32 | MP0003787_abnormal_imprinting | 1.50848643 |
| 33 | MP0000537_abnormal_urethra_morphology | 1.42103275 |
| 34 | MP0000026_abnormal_inner_ear | 1.41031698 |
| 35 | MP0002249_abnormal_larynx_morphology | 1.40319877 |
| 36 | MP0004742_abnormal_vestibular_system | 1.31044655 |
| 37 | MP0009745_abnormal_behavioral_response | 1.23868703 |
| 38 | MP0004215_abnormal_myocardial_fiber | 1.22485832 |
| 39 | MP0000955_abnormal_spinal_cord | 1.22001781 |
| 40 | MP0002697_abnormal_eye_size | 1.17735033 |
| 41 | MP0002233_abnormal_nose_morphology | 1.17493319 |
| 42 | MP0010030_abnormal_orbit_morphology | 1.16562440 |
| 43 | MP0008877_abnormal_DNA_methylation | 1.14920071 |
| 44 | MP0003693_abnormal_embryo_hatching | 1.14186776 |
| 45 | MP0001440_abnormal_grooming_behavior | 1.13836278 |
| 46 | MP0001348_abnormal_lacrimal_gland | 1.11729481 |
| 47 | MP0002272_abnormal_nervous_system | 1.11720867 |
| 48 | MP0002095_abnormal_skin_pigmentation | 1.09209969 |
| 49 | MP0005645_abnormal_hypothalamus_physiol | 1.08538225 |
| 50 | MP0002163_abnormal_gland_morphology | 1.07533527 |
| 51 | MP0002557_abnormal_social/conspecific_i | 1.06693763 |
| 52 | MP0003959_abnormal_lean_body | 1.06433630 |
| 53 | MP0001286_abnormal_eye_development | 1.05401226 |
| 54 | MP0003861_abnormal_nervous_system | 1.03790555 |
| 55 | MP0002752_abnormal_somatic_nervous | 1.03025440 |
| 56 | MP0009046_muscle_twitch | 1.01483928 |
| 57 | MP0002928_abnormal_bile_duct | 1.00422956 |
| 58 | MP0005551_abnormal_eye_electrophysiolog | 0.99760591 |
| 59 | MP0001486_abnormal_startle_reflex | 0.98120072 |
| 60 | MP0002736_abnormal_nociception_after | 0.97952295 |
| 61 | MP0008058_abnormal_DNA_repair | 0.97460814 |
| 62 | MP0003635_abnormal_synaptic_transmissio | 0.97116171 |
| 63 | MP0001963_abnormal_hearing_physiology | 0.97064739 |
| 64 | MP0002152_abnormal_brain_morphology | 0.96854123 |
| 65 | MP0002184_abnormal_innervation | 0.94308790 |
| 66 | MP0002064_seizures | 0.94049916 |
| 67 | MP0002116_abnormal_craniofacial_bone | 0.92399578 |
| 68 | MP0005195_abnormal_posterior_eye | 0.92178787 |
| 69 | MP0001188_hyperpigmentation | 0.91521188 |
| 70 | MP0001968_abnormal_touch/_nociception | 0.88954442 |
| 71 | MP0005423_abnormal_somatic_nervous | 0.87688521 |
| 72 | MP0002063_abnormal_learning/memory/cond | 0.87620482 |
| 73 | MP0008872_abnormal_physiological_respon | 0.86995253 |
| 74 | MP0002638_abnormal_pupillary_reflex | 0.86970859 |
| 75 | MP0002882_abnormal_neuron_morphology | 0.85770383 |
| 76 | MP0001986_abnormal_taste_sensitivity | 0.85763711 |
| 77 | MP0003718_maternal_effect | 0.85707052 |
| 78 | MP0001529_abnormal_vocalization | 0.85437166 |
| 79 | MP0004859_abnormal_synaptic_plasticity | 0.84651724 |
| 80 | MP0000427_abnormal_hair_cycle | 0.84073806 |
| 81 | MP0001984_abnormal_olfaction | 0.81664294 |
| 82 | MP0002109_abnormal_limb_morphology | 0.80660702 |
| 83 | MP0009250_abnormal_appendicular_skeleto | 0.80658102 |
| 84 | MP0005448_abnormal_energy_balance | 0.80453128 |
| 85 | MP0005174_abnormal_tail_pigmentation | 0.79324237 |
| 86 | MP0002067_abnormal_sensory_capabilities | 0.76750586 |
| 87 | MP0006072_abnormal_retinal_apoptosis | 0.76510331 |
| 88 | MP0002572_abnormal_emotion/affect_behav | 0.75029498 |
| 89 | MP0002092_abnormal_eye_morphology | 0.72202972 |
| 90 | MP0005391_vision/eye_phenotype | 0.71746679 |
| 91 | MP0005083_abnormal_biliary_tract | 0.71723314 |
| 92 | MP0005084_abnormal_gallbladder_morpholo | 0.71714921 |
| 93 | MP0001270_distended_abdomen | 0.69836696 |
| 94 | MP0002177_abnormal_outer_ear | 0.68183820 |
| 95 | MP0003567_abnormal_fetal_cardiomyocyte | 0.67018498 |
| 96 | MP0006035_abnormal_mitochondrial_morpho | 0.66293245 |
| 97 | MP0001970_abnormal_pain_threshold | 0.65970194 |
| 98 | MP0004811_abnormal_neuron_physiology | 0.64225356 |
| 99 | MP0005253_abnormal_eye_physiology | 0.63440803 |
| 100 | MP0002751_abnormal_autonomic_nervous | 0.63345639 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 7.08473708 |
| 2 | Partial duplication of thumb phalanx (HP:0009944) | 5.49425704 |
| 3 | Partial duplication of the phalanx of hand (HP:0009999) | 4.88207396 |
| 4 | Abnormality of midbrain morphology (HP:0002418) | 4.39986715 |
| 5 | Molar tooth sign on MRI (HP:0002419) | 4.39986715 |
| 6 | Retinal dysplasia (HP:0007973) | 3.20196119 |
| 7 | Duplication of thumb phalanx (HP:0009942) | 3.13213150 |
| 8 | Septo-optic dysplasia (HP:0100842) | 3.08047423 |
| 9 | Medial flaring of the eyebrow (HP:0010747) | 3.06998782 |
| 10 | Myokymia (HP:0002411) | 3.05649278 |
| 11 | Chronic hepatic failure (HP:0100626) | 2.97520006 |
| 12 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.92241292 |
| 13 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.91483578 |
| 14 | Hyperglycinemia (HP:0002154) | 2.87790165 |
| 15 | Nephrogenic diabetes insipidus (HP:0009806) | 2.74017672 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 2.73884578 |
| 17 | Nephronophthisis (HP:0000090) | 2.69269629 |
| 18 | 11 pairs of ribs (HP:0000878) | 2.67432262 |
| 19 | Acute encephalopathy (HP:0006846) | 2.66854678 |
| 20 | Gait imbalance (HP:0002141) | 2.65896481 |
| 21 | Sclerocornea (HP:0000647) | 2.62260091 |
| 22 | Stenosis of the external auditory canal (HP:0000402) | 2.58789314 |
| 23 | Pancreatic fibrosis (HP:0100732) | 2.57970716 |
| 24 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.54383918 |
| 25 | Congenital primary aphakia (HP:0007707) | 2.54113579 |
| 26 | Increased hepatocellular lipid droplets (HP:0006565) | 2.53947262 |
| 27 | Abnormality of renal resorption (HP:0011038) | 2.52684219 |
| 28 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.50584117 |
| 29 | Abnormality of the labia minora (HP:0012880) | 2.49904530 |
| 30 | Abnormal tarsal ossification (HP:0008369) | 2.46995882 |
| 31 | Persistence of primary teeth (HP:0006335) | 2.46348363 |
| 32 | Anencephaly (HP:0002323) | 2.46211072 |
| 33 | Pendular nystagmus (HP:0012043) | 2.43721793 |
| 34 | Type II lissencephaly (HP:0007260) | 2.43209657 |
| 35 | Macrocytic anemia (HP:0001972) | 2.38251293 |
| 36 | Hypoplasia of the pons (HP:0012110) | 2.37251406 |
| 37 | Anophthalmia (HP:0000528) | 2.35963838 |
| 38 | Bifid tongue (HP:0010297) | 2.33775954 |
| 39 | 3-Methylglutaconic aciduria (HP:0003535) | 2.33428940 |
| 40 | Mitochondrial inheritance (HP:0001427) | 2.31703400 |
| 41 | Vaginal atresia (HP:0000148) | 2.30413916 |
| 42 | Abnormality of the parietal bone (HP:0002696) | 2.30189635 |
| 43 | Hyperglycinuria (HP:0003108) | 2.25333314 |
| 44 | Abnormal hemoglobin (HP:0011902) | 2.25295665 |
| 45 | Genital tract atresia (HP:0001827) | 2.24873023 |
| 46 | Lipid accumulation in hepatocytes (HP:0006561) | 2.23962065 |
| 47 | Agitation (HP:0000713) | 2.18542576 |
| 48 | Absent septum pellucidum (HP:0001331) | 2.18537570 |
| 49 | Renal Fanconi syndrome (HP:0001994) | 2.17021046 |
| 50 | Progressive macrocephaly (HP:0004481) | 2.16780302 |
| 51 | Abnormality of the renal medulla (HP:0100957) | 2.15855776 |
| 52 | Degeneration of anterior horn cells (HP:0002398) | 2.12980952 |
| 53 | Abnormality of the anterior horn cell (HP:0006802) | 2.12980952 |
| 54 | Colon cancer (HP:0003003) | 2.12693705 |
| 55 | Microretrognathia (HP:0000308) | 2.11821015 |
| 56 | Increased intramyocellular lipid droplets (HP:0012240) | 2.08622919 |
| 57 | Lissencephaly (HP:0001339) | 2.07982583 |
| 58 | Synostosis involving the elbow (HP:0003938) | 2.07553746 |
| 59 | Humeroradial synostosis (HP:0003041) | 2.07553746 |
| 60 | Focal motor seizures (HP:0011153) | 2.06217070 |
| 61 | Small hand (HP:0200055) | 2.05803461 |
| 62 | Limb dystonia (HP:0002451) | 2.05003653 |
| 63 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.04373235 |
| 64 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.04373235 |
| 65 | Sleep apnea (HP:0010535) | 2.03923264 |
| 66 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.03125472 |
| 67 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.03125472 |
| 68 | Increased CSF lactate (HP:0002490) | 2.02176537 |
| 69 | Poor coordination (HP:0002370) | 2.01972829 |
| 70 | Pancreatic cysts (HP:0001737) | 2.01329951 |
| 71 | Osteomalacia (HP:0002749) | 2.01083888 |
| 72 | Congenital stationary night blindness (HP:0007642) | 2.00045214 |
| 73 | Abnormality of the pons (HP:0007361) | 1.98790869 |
| 74 | Postaxial foot polydactyly (HP:0001830) | 1.97270952 |
| 75 | Broad distal phalanx of finger (HP:0009836) | 1.93534607 |
| 76 | Holoprosencephaly (HP:0001360) | 1.93485847 |
| 77 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.92863121 |
| 78 | Pallor (HP:0000980) | 1.91807762 |
| 79 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.90301919 |
| 80 | Rectovaginal fistula (HP:0000143) | 1.87868241 |
| 81 | Rectal fistula (HP:0100590) | 1.87868241 |
| 82 | Abnormality of the aortic arch (HP:0012303) | 1.87637996 |
| 83 | Cerebellar dysplasia (HP:0007033) | 1.87201380 |
| 84 | Esotropia (HP:0000565) | 1.84310192 |
| 85 | Abnormality of abdominal situs (HP:0011620) | 1.83387265 |
| 86 | Abdominal situs inversus (HP:0003363) | 1.83387265 |
| 87 | Intellectual disability, moderate (HP:0002342) | 1.82986969 |
| 88 | Hypoplasia of the radius (HP:0002984) | 1.82678043 |
| 89 | Polyphagia (HP:0002591) | 1.82521034 |
| 90 | Postaxial hand polydactyly (HP:0001162) | 1.81573955 |
| 91 | Hepatocellular necrosis (HP:0001404) | 1.80750149 |
| 92 | Abnormal urine phosphate concentration (HP:0012599) | 1.78944833 |
| 93 | Abnormality of reticulocytes (HP:0004312) | 1.77939358 |
| 94 | Limb hypertonia (HP:0002509) | 1.75986723 |
| 95 | Overriding aorta (HP:0002623) | 1.75002454 |
| 96 | Specific learning disability (HP:0001328) | 1.73680130 |
| 97 | True hermaphroditism (HP:0010459) | 1.71585986 |
| 98 | Hip dysplasia (HP:0001385) | 1.71547174 |
| 99 | Oculomotor apraxia (HP:0000657) | 1.70650280 |
| 100 | Esophageal atresia (HP:0002032) | 1.69600382 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28 | 4.27048103 |
| 2 | GRK7 | 3.62485779 |
| 3 | ZAK | 3.47248612 |
| 4 | BUB1 | 3.30873269 |
| 5 | CDC7 | 2.79819630 |
| 6 | STK3 | 2.34571328 |
| 7 | UHMK1 | 2.29148034 |
| 8 | NEK2 | 2.12212136 |
| 9 | PINK1 | 2.08810318 |
| 10 | MAP3K4 | 2.06468041 |
| 11 | PLK4 | 2.04650480 |
| 12 | EPHA4 | 1.90921309 |
| 13 | NUAK1 | 1.86205001 |
| 14 | MARK2 | 1.79740877 |
| 15 | MAP2K7 | 1.76577822 |
| 16 | WNK3 | 1.75895551 |
| 17 | MAP4K2 | 1.71557495 |
| 18 | FGFR2 | 1.66636966 |
| 19 | ADRBK2 | 1.66115608 |
| 20 | SRPK1 | 1.64566459 |
| 21 | RPS6KA4 | 1.57576742 |
| 22 | TNIK | 1.55433482 |
| 23 | BCKDK | 1.43684529 |
| 24 | PLK2 | 1.42887954 |
| 25 | STK24 | 1.39967240 |
| 26 | BRAF | 1.39366463 |
| 27 | AURKA | 1.37204688 |
| 28 | MARK1 | 1.34496442 |
| 29 | DYRK2 | 1.34093801 |
| 30 | MAP2K4 | 1.29360886 |
| 31 | TYRO3 | 1.26575429 |
| 32 | VRK1 | 1.26061967 |
| 33 | CHEK2 | 1.24239600 |
| 34 | FRK | 1.19923044 |
| 35 | PLK3 | 1.16814850 |
| 36 | AKT3 | 1.14034299 |
| 37 | CAMK1 | 1.11366381 |
| 38 | PLK1 | 1.11344904 |
| 39 | DYRK3 | 1.11311573 |
| 40 | BCR | 1.09696840 |
| 41 | GRK1 | 1.05771117 |
| 42 | BRSK1 | 1.02952821 |
| 43 | PRKCG | 1.00913582 |
| 44 | CSNK1G2 | 0.99839908 |
| 45 | ADRBK1 | 0.96469871 |
| 46 | EPHB2 | 0.95110967 |
| 47 | SGK223 | 0.94802549 |
| 48 | SGK494 | 0.94802549 |
| 49 | PIK3CA | 0.93128036 |
| 50 | MAP3K11 | 0.92002349 |
| 51 | LATS1 | 0.86211750 |
| 52 | AURKB | 0.85304245 |
| 53 | PBK | 0.85081926 |
| 54 | MAP3K12 | 0.84578726 |
| 55 | CAMK4 | 0.81925535 |
| 56 | TTK | 0.80657662 |
| 57 | PDK2 | 0.77499920 |
| 58 | MAPK15 | 0.76947941 |
| 59 | MAP3K9 | 0.74889936 |
| 60 | SGK2 | 0.74810801 |
| 61 | WEE1 | 0.74810589 |
| 62 | WNK4 | 0.74133305 |
| 63 | PNCK | 0.71488976 |
| 64 | MKNK2 | 0.71162779 |
| 65 | ARAF | 0.65091435 |
| 66 | CSNK1G3 | 0.64608778 |
| 67 | PRKACA | 0.64099253 |
| 68 | NME1 | 0.63950733 |
| 69 | MINK1 | 0.60087107 |
| 70 | TIE1 | 0.59792661 |
| 71 | PRKCE | 0.59086839 |
| 72 | NEK1 | 0.58973485 |
| 73 | PRKCI | 0.58763450 |
| 74 | CSNK1G1 | 0.58696264 |
| 75 | IRAK1 | 0.58015126 |
| 76 | MKNK1 | 0.55797352 |
| 77 | CSNK2A2 | 0.54509046 |
| 78 | PAK3 | 0.53774562 |
| 79 | DYRK1B | 0.51245227 |
| 80 | SIK2 | 0.49981416 |
| 81 | CAMKK2 | 0.47560878 |
| 82 | CSNK1E | 0.42701761 |
| 83 | CAMK2A | 0.41658499 |
| 84 | CSNK1A1L | 0.41578946 |
| 85 | DYRK1A | 0.40653273 |
| 86 | MAP3K5 | 0.40571952 |
| 87 | CDK3 | 0.40424623 |
| 88 | INSRR | 0.39491114 |
| 89 | VRK2 | 0.37810827 |
| 90 | ERBB2 | 0.36824687 |
| 91 | STK39 | 0.36068306 |
| 92 | MAPK13 | 0.35921416 |
| 93 | CDK19 | 0.35090166 |
| 94 | PRKCA | 0.34728967 |
| 95 | PHKG1 | 0.34726209 |
| 96 | PHKG2 | 0.34726209 |
| 97 | CSNK1A1 | 0.33331236 |
| 98 | RPS6KA6 | 0.33113705 |
| 99 | CSNK2A1 | 0.32978908 |
| 100 | PKN1 | 0.31117301 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.24046523 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.70157188 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.93977577 |
| 4 | Huntingtons disease_Homo sapiens_hsa05016 | 3.12479506 |
| 5 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.79484193 |
| 6 | Alzheimers disease_Homo sapiens_hsa05010 | 2.60446800 |
| 7 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.24522350 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.18593359 |
| 9 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.12110257 |
| 10 | RNA degradation_Homo sapiens_hsa03018 | 2.10626613 |
| 11 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.99185479 |
| 12 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.98013184 |
| 13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.87489789 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 1.84873512 |
| 15 | Proteasome_Homo sapiens_hsa03050 | 1.76438500 |
| 16 | Phototransduction_Homo sapiens_hsa04744 | 1.72080682 |
| 17 | Nicotine addiction_Homo sapiens_hsa05033 | 1.62214966 |
| 18 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56347968 |
| 19 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.51016515 |
| 20 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.50930714 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.50542880 |
| 22 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.46864850 |
| 23 | Morphine addiction_Homo sapiens_hsa05032 | 1.45359763 |
| 24 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.44642317 |
| 25 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.36950186 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.33372855 |
| 27 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.31098492 |
| 28 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.30509428 |
| 29 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.25709301 |
| 30 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.22071686 |
| 31 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.21190953 |
| 32 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.15401419 |
| 33 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.12727685 |
| 34 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.08583059 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.07527655 |
| 36 | RNA transport_Homo sapiens_hsa03013 | 1.07511608 |
| 37 | Circadian entrainment_Homo sapiens_hsa04713 | 0.99523606 |
| 38 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.96206750 |
| 39 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.92867305 |
| 40 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.91954158 |
| 41 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.90065433 |
| 42 | Homologous recombination_Homo sapiens_hsa03440 | 0.84383490 |
| 43 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.83332258 |
| 44 | Melanoma_Homo sapiens_hsa05218 | 0.81132178 |
| 45 | Protein export_Homo sapiens_hsa03060 | 0.80369618 |
| 46 | Cocaine addiction_Homo sapiens_hsa05030 | 0.79026848 |
| 47 | Purine metabolism_Homo sapiens_hsa00230 | 0.78510326 |
| 48 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.74819408 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.74744110 |
| 50 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.71403339 |
| 51 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.69842450 |
| 52 | Olfactory transduction_Homo sapiens_hsa04740 | 0.69817293 |
| 53 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.66696098 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.64271075 |
| 55 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.62742620 |
| 56 | GABAergic synapse_Homo sapiens_hsa04727 | 0.62732384 |
| 57 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.62637975 |
| 58 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.62575370 |
| 59 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.62088572 |
| 60 | Base excision repair_Homo sapiens_hsa03410 | 0.60980816 |
| 61 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.59550163 |
| 62 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.59183699 |
| 63 | Mismatch repair_Homo sapiens_hsa03430 | 0.58100746 |
| 64 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.56891224 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56792726 |
| 66 | Basal transcription factors_Homo sapiens_hsa03022 | 0.56150011 |
| 67 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.55613961 |
| 68 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.54173799 |
| 69 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.53675803 |
| 70 | Cell cycle_Homo sapiens_hsa04110 | 0.53327335 |
| 71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.53225071 |
| 72 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.53075636 |
| 73 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.49172773 |
| 74 | Peroxisome_Homo sapiens_hsa04146 | 0.48756384 |
| 75 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.47644416 |
| 76 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.47538134 |
| 77 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.45544452 |
| 78 | Axon guidance_Homo sapiens_hsa04360 | 0.42860941 |
| 79 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.41156715 |
| 80 | Long-term depression_Homo sapiens_hsa04730 | 0.40639654 |
| 81 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.40132361 |
| 82 | Insulin secretion_Homo sapiens_hsa04911 | 0.39393435 |
| 83 | Sulfur relay system_Homo sapiens_hsa04122 | 0.35929186 |
| 84 | DNA replication_Homo sapiens_hsa03030 | 0.35660758 |
| 85 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.35266397 |
| 86 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.35259362 |
| 87 | Taste transduction_Homo sapiens_hsa04742 | 0.35222032 |
| 88 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.35134182 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.33897048 |
| 90 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.33790866 |
| 91 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.33148538 |
| 92 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.33003294 |
| 93 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.32500218 |
| 94 | Renin secretion_Homo sapiens_hsa04924 | 0.31474701 |
| 95 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.28296311 |
| 96 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.28055944 |
| 97 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.26299562 |
| 98 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.26032778 |
| 99 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.24803460 |
| 100 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.24083653 |

