

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | limb bud formation (GO:0060174) | 6.16583472 |
| 2 | negative regulation of T-helper cell differentiation (GO:0045623) | 6.07780310 |
| 3 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 6.07780310 |
| 4 | regulation of hippo signaling (GO:0035330) | 5.50921695 |
| 5 | positive regulation of granulocyte differentiation (GO:0030854) | 5.41803949 |
| 6 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 5.21198871 |
| 7 | cellular response to ethanol (GO:0071361) | 4.73009719 |
| 8 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 4.69873339 |
| 9 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.67747955 |
| 10 | cytokine production involved in immune response (GO:0002367) | 4.62289632 |
| 11 | regulation of MHC class II biosynthetic process (GO:0045346) | 4.58375496 |
| 12 | centrosome localization (GO:0051642) | 4.55392972 |
| 13 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 4.55357207 |
| 14 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 4.44322004 |
| 15 | T-helper cell differentiation (GO:0042093) | 4.44322004 |
| 16 | interkinetic nuclear migration (GO:0022027) | 4.34289486 |
| 17 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 4.34195289 |
| 18 | cytoplasmic mRNA processing body assembly (GO:0033962) | 4.29563395 |
| 19 | cellular ketone body metabolic process (GO:0046950) | 4.21351638 |
| 20 | regulation of chronic inflammatory response (GO:0002676) | 4.10017352 |
| 21 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.00996299 |
| 22 | regulation of immunoglobulin secretion (GO:0051023) | 3.97926639 |
| 23 | neural tube formation (GO:0001841) | 3.86080664 |
| 24 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 3.81271670 |
| 25 | protein import into peroxisome matrix (GO:0016558) | 3.81019680 |
| 26 | regulation of podosome assembly (GO:0071801) | 3.80018333 |
| 27 | somite development (GO:0061053) | 3.79451947 |
| 28 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.74494432 |
| 29 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.74494432 |
| 30 | T cell differentiation involved in immune response (GO:0002292) | 3.74494432 |
| 31 | ketone body metabolic process (GO:1902224) | 3.66993831 |
| 32 | positive regulation of organelle assembly (GO:1902117) | 3.60425564 |
| 33 | histone-serine phosphorylation (GO:0035404) | 3.53142201 |
| 34 | neuronal action potential (GO:0019228) | 3.50359492 |
| 35 | cornea development in camera-type eye (GO:0061303) | 3.49562067 |
| 36 | glucocorticoid receptor signaling pathway (GO:0042921) | 3.49326295 |
| 37 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.48867769 |
| 38 | regulation of interleukin-13 production (GO:0032656) | 3.45422577 |
| 39 | indole-containing compound catabolic process (GO:0042436) | 3.37826920 |
| 40 | indolalkylamine catabolic process (GO:0046218) | 3.37826920 |
| 41 | tryptophan catabolic process (GO:0006569) | 3.37826920 |
| 42 | T cell lineage commitment (GO:0002360) | 3.37580774 |
| 43 | cytokine biosynthetic process (GO:0042089) | 3.33127092 |
| 44 | syncytium formation (GO:0006949) | 3.31788221 |
| 45 | cell migration in hindbrain (GO:0021535) | 3.31478698 |
| 46 | positive regulation of immunoglobulin production (GO:0002639) | 3.28113262 |
| 47 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.26121499 |
| 48 | positive regulation of DNA recombination (GO:0045911) | 3.26034129 |
| 49 | regulation of pigment cell differentiation (GO:0050932) | 3.24170125 |
| 50 | positive regulation of isotype switching (GO:0045830) | 3.22803895 |
| 51 | outflow tract septum morphogenesis (GO:0003148) | 3.22525133 |
| 52 | lipid translocation (GO:0034204) | 3.20300998 |
| 53 | phospholipid translocation (GO:0045332) | 3.20300998 |
| 54 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.11798277 |
| 55 | regulation of gene silencing by miRNA (GO:0060964) | 3.11798277 |
| 56 | regulation of gene silencing by RNA (GO:0060966) | 3.11798277 |
| 57 | early endosome to late endosome transport (GO:0045022) | 3.10701876 |
| 58 | regulation of action potential (GO:0098900) | 3.10225863 |
| 59 | negative regulation of mast cell activation (GO:0033004) | 3.10117860 |
| 60 | detection of light stimulus involved in sensory perception (GO:0050962) | 3.09806402 |
| 61 | detection of light stimulus involved in visual perception (GO:0050908) | 3.09806402 |
| 62 | NLS-bearing protein import into nucleus (GO:0006607) | 3.09754614 |
| 63 | regulation of establishment of cell polarity (GO:2000114) | 3.08627646 |
| 64 | striatum development (GO:0021756) | 3.04911325 |
| 65 | regulation of granulocyte differentiation (GO:0030852) | 3.03492284 |
| 66 | behavioral response to nicotine (GO:0035095) | 2.96728406 |
| 67 | nucleoside transmembrane transport (GO:1901642) | 2.95111357 |
| 68 | nucleus localization (GO:0051647) | 2.92874087 |
| 69 | snRNA transcription (GO:0009301) | 2.92613786 |
| 70 | T cell mediated immunity (GO:0002456) | 2.92530127 |
| 71 | innate immune response in mucosa (GO:0002227) | 2.91703980 |
| 72 | positive regulation of developmental pigmentation (GO:0048087) | 2.91271478 |
| 73 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 2.87639519 |
| 74 | negative regulation of acute inflammatory response (GO:0002674) | 2.86222852 |
| 75 | positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110 | 2.84922404 |
| 76 | mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686) | 2.84922404 |
| 77 | genitalia morphogenesis (GO:0035112) | 2.81932654 |
| 78 | pharyngeal system development (GO:0060037) | 2.81151660 |
| 79 | response to mercury ion (GO:0046689) | 2.80528577 |
| 80 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.77512473 |
| 81 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.77402781 |
| 82 | negative regulation of neurological system process (GO:0031645) | 2.76296885 |
| 83 | response to inactivity (GO:0014854) | 2.75994600 |
| 84 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 2.75483791 |
| 85 | corticosteroid receptor signaling pathway (GO:0031958) | 2.75294059 |
| 86 | protein K48-linked deubiquitination (GO:0071108) | 2.74751379 |
| 87 | spermatid nucleus differentiation (GO:0007289) | 2.73983479 |
| 88 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.73610415 |
| 89 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.73610415 |
| 90 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.73610415 |
| 91 | nuclear pore complex assembly (GO:0051292) | 2.73075934 |
| 92 | positive regulation of DNA-templated transcription, initiation (GO:2000144) | 2.71232709 |
| 93 | tryptophan metabolic process (GO:0006568) | 2.67972140 |
| 94 | regulation of establishment or maintenance of cell polarity (GO:0032878) | 2.67697182 |
| 95 | nuclear pore organization (GO:0006999) | 2.65506536 |
| 96 | cytokine metabolic process (GO:0042107) | 2.65447547 |
| 97 | regulation of heat generation (GO:0031650) | 2.64512303 |
| 98 | ether lipid metabolic process (GO:0046485) | 2.62989899 |
| 99 | regulation of MHC class I biosynthetic process (GO:0045343) | 2.62578177 |
| 100 | intestinal cholesterol absorption (GO:0030299) | 2.60681410 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 4.91004037 |
| 2 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 4.73262082 |
| 3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.16398134 |
| 4 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 3.61637752 |
| 5 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.73543677 |
| 6 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.56014963 |
| 7 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.51170115 |
| 8 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.34537416 |
| 9 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.27382944 |
| 10 | ER_23166858_ChIP-Seq_MCF-7_Human | 2.24797692 |
| 11 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 2.18004556 |
| 12 | STAT3_23295773_ChIP-Seq_U87_Human | 1.99883928 |
| 13 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.92375786 |
| 14 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.90855730 |
| 15 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.86412490 |
| 16 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.84270303 |
| 17 | TP53_16413492_ChIP-PET_HCT116_Human | 1.79091351 |
| 18 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.77044154 |
| 19 | FUS_26573619_Chip-Seq_HEK293_Human | 1.76299897 |
| 20 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.76227059 |
| 21 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.73354462 |
| 22 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.72198599 |
| 23 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.71078142 |
| 24 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.67035121 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.58360160 |
| 26 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.57406020 |
| 27 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.55039146 |
| 28 | EWS_26573619_Chip-Seq_HEK293_Human | 1.54706830 |
| 29 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.54683599 |
| 30 | TCF4_23295773_ChIP-Seq_U87_Human | 1.54546746 |
| 31 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.53501013 |
| 32 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.51521240 |
| 33 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.51268628 |
| 34 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.47397612 |
| 35 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.47370539 |
| 36 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.46745029 |
| 37 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.46674248 |
| 38 | AR_25329375_ChIP-Seq_VCAP_Human | 1.45681760 |
| 39 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.44676414 |
| 40 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.43172107 |
| 41 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.42779731 |
| 42 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.42400754 |
| 43 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.42124621 |
| 44 | RXR_22108803_ChIP-Seq_LS180_Human | 1.41203809 |
| 45 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.41179785 |
| 46 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.39463799 |
| 47 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.39463799 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.39280951 |
| 49 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.36150557 |
| 50 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.35581839 |
| 51 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.31378870 |
| 52 | VDR_22108803_ChIP-Seq_LS180_Human | 1.29599860 |
| 53 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.28712657 |
| 54 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.28684352 |
| 55 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.28239344 |
| 56 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.28181569 |
| 57 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.27949332 |
| 58 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.27948639 |
| 59 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.24261713 |
| 60 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.23777850 |
| 61 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.22714408 |
| 62 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.19374682 |
| 63 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.17324796 |
| 64 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.16799962 |
| 65 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.16101617 |
| 66 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.15084606 |
| 67 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.13368193 |
| 68 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.13249230 |
| 69 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.12345977 |
| 70 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.12274512 |
| 71 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.10923359 |
| 72 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.07598751 |
| 73 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.07170024 |
| 74 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.05832814 |
| 75 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.05696142 |
| 76 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.05566738 |
| 77 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.05566738 |
| 78 | TBL1_22424771_ChIP-Seq_293T_Human | 1.04821996 |
| 79 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.04633329 |
| 80 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.03712944 |
| 81 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.03294151 |
| 82 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.03229786 |
| 83 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.02548038 |
| 84 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.02131246 |
| 85 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.02131246 |
| 86 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.01384965 |
| 87 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.00619515 |
| 88 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.00005188 |
| 89 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.99426185 |
| 90 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.99243841 |
| 91 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.98519964 |
| 92 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.98302889 |
| 93 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.97579621 |
| 94 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.97391139 |
| 95 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.96854904 |
| 96 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.96404423 |
| 97 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.95711486 |
| 98 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.95645885 |
| 99 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.94540841 |
| 100 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.94422388 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 6.19513017 |
| 2 | MP0001348_abnormal_lacrimal_gland | 4.67002473 |
| 3 | MP0002822_catalepsy | 4.54131462 |
| 4 | MP0008057_abnormal_DNA_replication | 4.35500735 |
| 5 | MP0001873_stomach_inflammation | 4.24095750 |
| 6 | MP0010030_abnormal_orbit_morphology | 3.97369475 |
| 7 | MP0005670_abnormal_white_adipose | 3.73380234 |
| 8 | MP0002009_preneoplasia | 2.80893883 |
| 9 | MP0005248_abnormal_Harderian_gland | 2.78566953 |
| 10 | MP0001986_abnormal_taste_sensitivity | 2.48547121 |
| 11 | MP0005310_abnormal_salivary_gland | 2.41740272 |
| 12 | MP0005410_abnormal_fertilization | 1.94056351 |
| 13 | MP0003718_maternal_effect | 1.90583144 |
| 14 | MP0005174_abnormal_tail_pigmentation | 1.87333083 |
| 15 | MP0000427_abnormal_hair_cycle | 1.83173012 |
| 16 | MP0006082_CNS_inflammation | 1.76315261 |
| 17 | MP0003763_abnormal_thymus_physiology | 1.73252359 |
| 18 | MP0004142_abnormal_muscle_tone | 1.65520776 |
| 19 | MP0003656_abnormal_erythrocyte_physiolo | 1.62400149 |
| 20 | MP0008875_abnormal_xenobiotic_pharmacok | 1.62113556 |
| 21 | MP0005266_abnormal_metabolism | 1.60801488 |
| 22 | MP0000371_diluted_coat_color | 1.47524310 |
| 23 | MP0005083_abnormal_biliary_tract | 1.45752041 |
| 24 | MP0005365_abnormal_bile_salt | 1.45127200 |
| 25 | MP0001879_abnormal_lymphatic_vessel | 1.44085061 |
| 26 | MP0005075_abnormal_melanosome_morpholog | 1.44013257 |
| 27 | MP0008877_abnormal_DNA_methylation | 1.41421658 |
| 28 | MP0008995_early_reproductive_senescence | 1.40979631 |
| 29 | MP0006054_spinal_hemorrhage | 1.40884912 |
| 30 | MP0008961_abnormal_basal_metabolism | 1.37160030 |
| 31 | MP0003195_calcinosis | 1.33455988 |
| 32 | MP0000534_abnormal_ureter_morphology | 1.31583105 |
| 33 | MP0005551_abnormal_eye_electrophysiolog | 1.25327248 |
| 34 | MP0001984_abnormal_olfaction | 1.24793096 |
| 35 | MP0005085_abnormal_gallbladder_physiolo | 1.22119872 |
| 36 | MP0010329_abnormal_lipoprotein_level | 1.21966614 |
| 37 | MP0003252_abnormal_bile_duct | 1.16778886 |
| 38 | MP0000647_abnormal_sebaceous_gland | 1.16442689 |
| 39 | MP0004742_abnormal_vestibular_system | 1.15204552 |
| 40 | MP0009840_abnormal_foam_cell | 1.13848728 |
| 41 | MP0001835_abnormal_antigen_presentation | 1.06707989 |
| 42 | MP0004130_abnormal_muscle_cell | 1.04895250 |
| 43 | MP0009115_abnormal_fat_cell | 1.04687501 |
| 44 | MP0005253_abnormal_eye_physiology | 1.04635137 |
| 45 | MP0001501_abnormal_sleep_pattern | 1.04143792 |
| 46 | MP0004381_abnormal_hair_follicle | 0.98263758 |
| 47 | MP0002166_altered_tumor_susceptibility | 0.96274904 |
| 48 | MP0005395_other_phenotype | 0.92294505 |
| 49 | MP0008872_abnormal_physiological_respon | 0.89756214 |
| 50 | MP0004084_abnormal_cardiac_muscle | 0.88607853 |
| 51 | MP0000383_abnormal_hair_follicle | 0.87168836 |
| 52 | MP0005666_abnormal_adipose_tissue | 0.86842791 |
| 53 | MP0003880_abnormal_central_pattern | 0.86500828 |
| 54 | MP0002876_abnormal_thyroid_physiology | 0.85063881 |
| 55 | MP0003959_abnormal_lean_body | 0.84574926 |
| 56 | MP0004808_abnormal_hematopoietic_stem | 0.83913134 |
| 57 | MP0001929_abnormal_gametogenesis | 0.81453777 |
| 58 | MP0003698_abnormal_male_reproductive | 0.81318452 |
| 59 | MP0005448_abnormal_energy_balance | 0.80448868 |
| 60 | MP0003943_abnormal_hepatobiliary_system | 0.79923160 |
| 61 | MP0004484_altered_response_of | 0.79874004 |
| 62 | MP0005595_abnormal_vascular_smooth | 0.78582563 |
| 63 | MP0005076_abnormal_cell_differentiation | 0.77039158 |
| 64 | MP0000470_abnormal_stomach_morphology | 0.76697453 |
| 65 | MP0002332_abnormal_exercise_endurance | 0.76293948 |
| 66 | MP0004885_abnormal_endolymph | 0.76166086 |
| 67 | MP0002282_abnormal_trachea_morphology | 0.74693235 |
| 68 | MP0006072_abnormal_retinal_apoptosis | 0.74308906 |
| 69 | MP0002751_abnormal_autonomic_nervous | 0.73535004 |
| 70 | MP0001286_abnormal_eye_development | 0.72228054 |
| 71 | MP0009278_abnormal_bone_marrow | 0.70281785 |
| 72 | MP0003221_abnormal_cardiomyocyte_apopto | 0.69644378 |
| 73 | MP0005376_homeostasis/metabolism_phenot | 0.69500903 |
| 74 | MP0003868_abnormal_feces_composition | 0.68744267 |
| 75 | MP0010368_abnormal_lymphatic_system | 0.63747362 |
| 76 | MP0002075_abnormal_coat/hair_pigmentati | 0.63063378 |
| 77 | MP0003699_abnormal_female_reproductive | 0.62940524 |
| 78 | MP0004036_abnormal_muscle_relaxation | 0.61715536 |
| 79 | MP0002210_abnormal_sex_determination | 0.61703377 |
| 80 | MP0008775_abnormal_heart_ventricle | 0.60900174 |
| 81 | MP0001502_abnormal_circadian_rhythm | 0.59803497 |
| 82 | MP0000230_abnormal_systemic_arterial | 0.59211844 |
| 83 | MP0003786_premature_aging | 0.58891921 |
| 84 | MP0004264_abnormal_extraembryonic_tissu | 0.58567386 |
| 85 | MP0003632_abnormal_nervous_system | 0.58119315 |
| 86 | MP0008004_abnormal_stomach_pH | 0.57427347 |
| 87 | MP0000613_abnormal_salivary_gland | 0.56785748 |
| 88 | MP0001661_extended_life_span | 0.56182236 |
| 89 | MP0004134_abnormal_chest_morphology | 0.55508829 |
| 90 | MP0001800_abnormal_humoral_immune | 0.54154722 |
| 91 | MP0008770_decreased_survivor_rate | 0.52853426 |
| 92 | MP0006138_congestive_heart_failure | 0.52819021 |
| 93 | MP0005197_abnormal_uvea_morphology | 0.52743602 |
| 94 | MP0003567_abnormal_fetal_cardiomyocyte | 0.49920926 |
| 95 | MP0005375_adipose_tissue_phenotype | 0.49352302 |
| 96 | MP0003045_fibrosis | 0.49323432 |
| 97 | MP0002932_abnormal_joint_morphology | 0.48126824 |
| 98 | MP0006276_abnormal_autonomic_nervous | 0.46925552 |
| 99 | MP0000516_abnormal_urinary_system | 0.46883327 |
| 100 | MP0005367_renal/urinary_system_phenotyp | 0.46883327 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased density of long bones (HP:0006392) | 5.17173211 |
| 2 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 4.87058673 |
| 3 | Short 1st metacarpal (HP:0010034) | 4.87058673 |
| 4 | Short phalanx of the thumb (HP:0009660) | 4.84971207 |
| 5 | Bicornuate uterus (HP:0000813) | 4.58149634 |
| 6 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 4.49273354 |
| 7 | Abnormality of the 1st metacarpal (HP:0010009) | 4.18365149 |
| 8 | Long clavicles (HP:0000890) | 3.96107530 |
| 9 | Chronic hepatic failure (HP:0100626) | 3.86042639 |
| 10 | Hepatoblastoma (HP:0002884) | 3.81997314 |
| 11 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 3.77968312 |
| 12 | Abnormal pancreas size (HP:0012094) | 3.76663286 |
| 13 | Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658) | 3.63687824 |
| 14 | Annular pancreas (HP:0001734) | 3.62798952 |
| 15 | Fair hair (HP:0002286) | 3.51604471 |
| 16 | Hyperventilation (HP:0002883) | 3.51136497 |
| 17 | Decreased lacrimation (HP:0000633) | 3.47411853 |
| 18 | Alacrima (HP:0000522) | 3.40187052 |
| 19 | Hypoplastic nipples (HP:0002557) | 3.31317617 |
| 20 | Abnormality of the pubic bones (HP:0003172) | 3.30083747 |
| 21 | Broad ribs (HP:0000885) | 3.16903618 |
| 22 | Hypoplastic labia majora (HP:0000059) | 3.15378913 |
| 23 | Large for gestational age (HP:0001520) | 3.13405478 |
| 24 | Abnormality of the labia majora (HP:0012881) | 3.10172453 |
| 25 | Facial hemangioma (HP:0000329) | 3.01596897 |
| 26 | Absent speech (HP:0001344) | 2.98267389 |
| 27 | Generalized hypopigmentation of hair (HP:0011358) | 2.96681756 |
| 28 | Abnormality of the fingertips (HP:0001211) | 2.72965608 |
| 29 | Abnormality of the nasal septum (HP:0000419) | 2.68118850 |
| 30 | Germ cell neoplasia (HP:0100728) | 2.66122405 |
| 31 | Abnormality of the labia minora (HP:0012880) | 2.64212137 |
| 32 | Abnormality of the renal cortex (HP:0011035) | 2.62139504 |
| 33 | Inability to walk (HP:0002540) | 2.57333915 |
| 34 | Protruding tongue (HP:0010808) | 2.48350413 |
| 35 | Ureteral stenosis (HP:0000071) | 2.42214972 |
| 36 | Poikilocytosis (HP:0004447) | 2.34833438 |
| 37 | Ureteral obstruction (HP:0006000) | 2.29186380 |
| 38 | Acanthocytosis (HP:0001927) | 2.28919481 |
| 39 | Abnormality of the sella turcica (HP:0002679) | 2.28836360 |
| 40 | Neoplasm of the heart (HP:0100544) | 2.28260783 |
| 41 | Macroglossia (HP:0000158) | 2.27365810 |
| 42 | Short 4th metacarpal (HP:0010044) | 2.26063488 |
| 43 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.26063488 |
| 44 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.22340205 |
| 45 | Attenuation of retinal blood vessels (HP:0007843) | 2.21957414 |
| 46 | Deformed sella turcica (HP:0002681) | 2.21834774 |
| 47 | Widely patent fontanelles and sutures (HP:0004492) | 2.21696343 |
| 48 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 2.18687413 |
| 49 | Opisthotonus (HP:0002179) | 2.14596629 |
| 50 | Progressive cerebellar ataxia (HP:0002073) | 2.13377229 |
| 51 | Pancreatic cysts (HP:0001737) | 2.10818009 |
| 52 | Abnormality of the pons (HP:0007361) | 2.09832088 |
| 53 | Anterior segment dysgenesis (HP:0007700) | 2.09387996 |
| 54 | Submucous cleft hard palate (HP:0000176) | 2.05137393 |
| 55 | Truncal obesity (HP:0001956) | 2.04315730 |
| 56 | Short foot (HP:0001773) | 2.02340100 |
| 57 | Adactyly (HP:0009776) | 2.00982221 |
| 58 | Broad nasal tip (HP:0000455) | 1.99654376 |
| 59 | Decreased skull ossification (HP:0004331) | 1.97407115 |
| 60 | Tapered finger (HP:0001182) | 1.96910939 |
| 61 | Hypoplasia of the pons (HP:0012110) | 1.96680083 |
| 62 | Prominent forehead (HP:0011220) | 1.95660877 |
| 63 | Entropion (HP:0000621) | 1.94728790 |
| 64 | Gaze-evoked nystagmus (HP:0000640) | 1.94139598 |
| 65 | Hydroureter (HP:0000072) | 1.93783555 |
| 66 | Hypobetalipoproteinemia (HP:0003563) | 1.91677255 |
| 67 | Prominent nose (HP:0000448) | 1.90497974 |
| 68 | Abnormality of macular pigmentation (HP:0008002) | 1.90098263 |
| 69 | Partial agenesis of the corpus callosum (HP:0001338) | 1.86206921 |
| 70 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.84509137 |
| 71 | Relative macrocephaly (HP:0004482) | 1.83669507 |
| 72 | Cerebellar dysplasia (HP:0007033) | 1.80874275 |
| 73 | Stomatitis (HP:0010280) | 1.80714884 |
| 74 | Congenital stationary night blindness (HP:0007642) | 1.77037124 |
| 75 | Clumsiness (HP:0002312) | 1.76204821 |
| 76 | Anophthalmia (HP:0000528) | 1.76160686 |
| 77 | Abnormality of the epiphyses of the phalanges of the hand (HP:0005920) | 1.74815876 |
| 78 | Thyroiditis (HP:0100646) | 1.74550031 |
| 79 | Short distal phalanx of finger (HP:0009882) | 1.74056998 |
| 80 | Labial hypoplasia (HP:0000066) | 1.71856949 |
| 81 | Genetic anticipation (HP:0003743) | 1.71435074 |
| 82 | Stomach cancer (HP:0012126) | 1.70069820 |
| 83 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.69634462 |
| 84 | Abnormality of the renal medulla (HP:0100957) | 1.69219373 |
| 85 | Hypoplastic iliac wings (HP:0002866) | 1.68765272 |
| 86 | Abnormal auditory evoked potentials (HP:0006958) | 1.67718266 |
| 87 | Aplasia/Hypoplasia of the hallux (HP:0008362) | 1.67356484 |
| 88 | Sparse lateral eyebrow (HP:0005338) | 1.66503759 |
| 89 | Anteriorly placed anus (HP:0001545) | 1.66121801 |
| 90 | Tubular atrophy (HP:0000092) | 1.64974411 |
| 91 | Narrow palate (HP:0000189) | 1.64167353 |
| 92 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 1.63842974 |
| 93 | Visual hallucinations (HP:0002367) | 1.63182329 |
| 94 | Congenital sensorineural hearing impairment (HP:0008527) | 1.63077443 |
| 95 | Widely spaced teeth (HP:0000687) | 1.62837687 |
| 96 | Impulsivity (HP:0100710) | 1.62755914 |
| 97 | Long nose (HP:0003189) | 1.62147624 |
| 98 | Neurodegeneration (HP:0002180) | 1.60500150 |
| 99 | Heterotopia (HP:0002282) | 1.60283857 |
| 100 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.59173238 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PINK1 | 5.07040116 |
| 2 | FRK | 4.43856205 |
| 3 | PBK | 4.28010675 |
| 4 | CAMK1D | 3.24212282 |
| 5 | PIK3CG | 3.19149280 |
| 6 | MAP4K2 | 3.18819597 |
| 7 | CAMK1G | 2.96203332 |
| 8 | AKT3 | 2.91966933 |
| 9 | BRD4 | 2.79288187 |
| 10 | CAMKK2 | 2.28191820 |
| 11 | ZAK | 2.22596567 |
| 12 | PDK2 | 2.09910033 |
| 13 | BRSK2 | 1.95943963 |
| 14 | TNIK | 1.90319172 |
| 15 | ACVR1B | 1.85983005 |
| 16 | STK38L | 1.80752214 |
| 17 | SIK2 | 1.66930964 |
| 18 | MARK3 | 1.60599608 |
| 19 | CDK12 | 1.55500849 |
| 20 | EEF2K | 1.54240787 |
| 21 | NEK6 | 1.43961399 |
| 22 | TLK1 | 1.36901888 |
| 23 | WNK1 | 1.30286606 |
| 24 | MAPK13 | 1.28047921 |
| 25 | TRPM7 | 1.25352650 |
| 26 | KSR1 | 1.20296383 |
| 27 | TAOK3 | 1.13878124 |
| 28 | NLK | 1.09891828 |
| 29 | PTK2B | 1.09269352 |
| 30 | CASK | 1.08381438 |
| 31 | PIM1 | 1.05129975 |
| 32 | DYRK1B | 0.98989129 |
| 33 | CDK6 | 0.97775207 |
| 34 | MST4 | 0.97344276 |
| 35 | NEK9 | 0.95641439 |
| 36 | STK24 | 0.95532952 |
| 37 | MKNK2 | 0.95193096 |
| 38 | MAPK11 | 0.91830890 |
| 39 | TYRO3 | 0.87460053 |
| 40 | STK4 | 0.85482296 |
| 41 | STK39 | 0.82945785 |
| 42 | PRKAA2 | 0.79631172 |
| 43 | TEC | 0.77808792 |
| 44 | ITK | 0.77607721 |
| 45 | WNK4 | 0.74998870 |
| 46 | FLT3 | 0.74403600 |
| 47 | MET | 0.73594025 |
| 48 | MKNK1 | 0.73426990 |
| 49 | BMPR1B | 0.71942406 |
| 50 | MAP3K7 | 0.70937828 |
| 51 | CHUK | 0.69109862 |
| 52 | CAMKK1 | 0.68369510 |
| 53 | CAMK4 | 0.66820236 |
| 54 | SGK2 | 0.64747297 |
| 55 | ADRBK2 | 0.63602619 |
| 56 | PDGFRB | 0.63018760 |
| 57 | MELK | 0.62323884 |
| 58 | PRKAA1 | 0.60760029 |
| 59 | STK11 | 0.60559723 |
| 60 | SGK3 | 0.58950661 |
| 61 | YES1 | 0.52423889 |
| 62 | RPS6KB2 | 0.51556298 |
| 63 | NME1 | 0.51525716 |
| 64 | TGFBR1 | 0.51305043 |
| 65 | PIK3CA | 0.51161374 |
| 66 | IKBKB | 0.50583218 |
| 67 | CDK4 | 0.49296493 |
| 68 | BTK | 0.49007696 |
| 69 | PDK1 | 0.46719294 |
| 70 | PNCK | 0.45728258 |
| 71 | TXK | 0.43688732 |
| 72 | FGFR3 | 0.42016086 |
| 73 | SGK494 | 0.41970660 |
| 74 | SGK223 | 0.41970660 |
| 75 | CSNK1D | 0.41826404 |
| 76 | GRK1 | 0.40432977 |
| 77 | SIK3 | 0.39663848 |
| 78 | STK3 | 0.39150147 |
| 79 | MTOR | 0.37039835 |
| 80 | ERBB2 | 0.34315761 |
| 81 | SGK1 | 0.32931519 |
| 82 | CAMK1 | 0.31269248 |
| 83 | LCK | 0.30905267 |
| 84 | PDPK1 | 0.29948617 |
| 85 | GSK3B | 0.29663731 |
| 86 | MYLK | 0.28651267 |
| 87 | MAPK10 | 0.27836133 |
| 88 | OXSR1 | 0.27529191 |
| 89 | MAPK8 | 0.26838128 |
| 90 | ATM | 0.26581803 |
| 91 | PRKCZ | 0.26415140 |
| 92 | RPS6KA5 | 0.25422974 |
| 93 | OBSCN | 0.24803543 |
| 94 | MAPK15 | 0.24671396 |
| 95 | MAPK1 | 0.24406692 |
| 96 | ABL1 | 0.24029262 |
| 97 | MARK2 | 0.23521757 |
| 98 | MAPK14 | 0.21971843 |
| 99 | TNK2 | 0.21248006 |
| 100 | CSNK1A1 | 0.20869616 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.80065153 |
| 2 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.57218000 |
| 3 | Asthma_Homo sapiens_hsa05310 | 2.43985595 |
| 4 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.26960811 |
| 5 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.02849657 |
| 6 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.02391115 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.92220082 |
| 8 | Lysine degradation_Homo sapiens_hsa00310 | 1.89967872 |
| 9 | ABC transporters_Homo sapiens_hsa02010 | 1.86017973 |
| 10 | Allograft rejection_Homo sapiens_hsa05330 | 1.79072979 |
| 11 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.77344969 |
| 12 | Taste transduction_Homo sapiens_hsa04742 | 1.72310267 |
| 13 | Phototransduction_Homo sapiens_hsa04744 | 1.64859849 |
| 14 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.63708194 |
| 15 | Circadian rhythm_Homo sapiens_hsa04710 | 1.51920553 |
| 16 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.51031899 |
| 17 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.49959012 |
| 18 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.46107345 |
| 19 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.43453103 |
| 20 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.40240775 |
| 21 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.35586896 |
| 22 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.31867039 |
| 23 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.28427380 |
| 24 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.27374279 |
| 25 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.25657796 |
| 26 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.19511610 |
| 27 | RNA polymerase_Homo sapiens_hsa03020 | 1.19240245 |
| 28 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.15154437 |
| 29 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.14285338 |
| 30 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.13884725 |
| 31 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.13632664 |
| 32 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.12004244 |
| 33 | Cocaine addiction_Homo sapiens_hsa05030 | 1.11131168 |
| 34 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.09971948 |
| 35 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.04938610 |
| 36 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.02594539 |
| 37 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.02441781 |
| 38 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.01748320 |
| 39 | Platelet activation_Homo sapiens_hsa04611 | 0.99571019 |
| 40 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.98748893 |
| 41 | Salivary secretion_Homo sapiens_hsa04970 | 0.96926826 |
| 42 | Alcoholism_Homo sapiens_hsa05034 | 0.94855977 |
| 43 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.94212268 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.93232538 |
| 45 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.88487108 |
| 46 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.88161128 |
| 47 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.86880453 |
| 48 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.86196412 |
| 49 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.83805242 |
| 50 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.81833200 |
| 51 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.76680461 |
| 52 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.76517131 |
| 53 | Morphine addiction_Homo sapiens_hsa05032 | 0.75638646 |
| 54 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.73235602 |
| 55 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.72291333 |
| 56 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.72281400 |
| 57 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.70238914 |
| 58 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.69215796 |
| 59 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.68684048 |
| 60 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.67290637 |
| 61 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.65831568 |
| 62 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.64454594 |
| 63 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.64354104 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.64199288 |
| 65 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.63797416 |
| 66 | Measles_Homo sapiens_hsa05162 | 0.62474917 |
| 67 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.61553564 |
| 68 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.60636314 |
| 69 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.59486931 |
| 70 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.59087309 |
| 71 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.58766695 |
| 72 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.57802938 |
| 73 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.53831964 |
| 74 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.52927482 |
| 75 | Pathways in cancer_Homo sapiens_hsa05200 | 0.52742067 |
| 76 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.52258183 |
| 77 | Nicotine addiction_Homo sapiens_hsa05033 | 0.51685160 |
| 78 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.51651802 |
| 79 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.51337238 |
| 80 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.50178398 |
| 81 | Olfactory transduction_Homo sapiens_hsa04740 | 0.49997923 |
| 82 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.49446106 |
| 83 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.48729388 |
| 84 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.48433694 |
| 85 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.45965359 |
| 86 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.45212178 |
| 87 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.45183471 |
| 88 | Axon guidance_Homo sapiens_hsa04360 | 0.44843669 |
| 89 | Prostate cancer_Homo sapiens_hsa05215 | 0.44704442 |
| 90 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.43824982 |
| 91 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.43206333 |
| 92 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.42266790 |
| 93 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.41884488 |
| 94 | Insulin resistance_Homo sapiens_hsa04931 | 0.41192562 |
| 95 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.41110029 |
| 96 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.39621229 |
| 97 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.38355524 |
| 98 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.36634334 |
| 99 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.35540452 |
| 100 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.35098037 |

