HMGB3P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)6.16583472
2negative regulation of T-helper cell differentiation (GO:0045623)6.07780310
3negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)6.07780310
4regulation of hippo signaling (GO:0035330)5.50921695
5positive regulation of granulocyte differentiation (GO:0030854)5.41803949
6CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.21198871
7cellular response to ethanol (GO:0071361)4.73009719
8negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.69873339
9regulation of isotype switching to IgG isotypes (GO:0048302)4.67747955
10cytokine production involved in immune response (GO:0002367)4.62289632
11regulation of MHC class II biosynthetic process (GO:0045346)4.58375496
12centrosome localization (GO:0051642)4.55392972
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.55357207
14CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.44322004
15T-helper cell differentiation (GO:0042093)4.44322004
16interkinetic nuclear migration (GO:0022027)4.34289486
17negative regulation of alpha-beta T cell differentiation (GO:0046639)4.34195289
18cytoplasmic mRNA processing body assembly (GO:0033962)4.29563395
19cellular ketone body metabolic process (GO:0046950)4.21351638
20regulation of chronic inflammatory response (GO:0002676)4.10017352
21positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.00996299
22regulation of immunoglobulin secretion (GO:0051023)3.97926639
23neural tube formation (GO:0001841)3.86080664
24cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.81271670
25protein import into peroxisome matrix (GO:0016558)3.81019680
26regulation of podosome assembly (GO:0071801)3.80018333
27somite development (GO:0061053)3.79451947
28alpha-beta T cell differentiation involved in immune response (GO:0002293)3.74494432
29alpha-beta T cell activation involved in immune response (GO:0002287)3.74494432
30T cell differentiation involved in immune response (GO:0002292)3.74494432
31ketone body metabolic process (GO:1902224)3.66993831
32positive regulation of organelle assembly (GO:1902117)3.60425564
33histone-serine phosphorylation (GO:0035404)3.53142201
34neuronal action potential (GO:0019228)3.50359492
35cornea development in camera-type eye (GO:0061303)3.49562067
36glucocorticoid receptor signaling pathway (GO:0042921)3.49326295
37regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.48867769
38regulation of interleukin-13 production (GO:0032656)3.45422577
39indole-containing compound catabolic process (GO:0042436)3.37826920
40indolalkylamine catabolic process (GO:0046218)3.37826920
41tryptophan catabolic process (GO:0006569)3.37826920
42T cell lineage commitment (GO:0002360)3.37580774
43cytokine biosynthetic process (GO:0042089)3.33127092
44syncytium formation (GO:0006949)3.31788221
45cell migration in hindbrain (GO:0021535)3.31478698
46positive regulation of immunoglobulin production (GO:0002639)3.28113262
47CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.26121499
48positive regulation of DNA recombination (GO:0045911)3.26034129
49regulation of pigment cell differentiation (GO:0050932)3.24170125
50positive regulation of isotype switching (GO:0045830)3.22803895
51outflow tract septum morphogenesis (GO:0003148)3.22525133
52lipid translocation (GO:0034204)3.20300998
53phospholipid translocation (GO:0045332)3.20300998
54regulation of posttranscriptional gene silencing (GO:0060147)3.11798277
55regulation of gene silencing by miRNA (GO:0060964)3.11798277
56regulation of gene silencing by RNA (GO:0060966)3.11798277
57early endosome to late endosome transport (GO:0045022)3.10701876
58regulation of action potential (GO:0098900)3.10225863
59negative regulation of mast cell activation (GO:0033004)3.10117860
60detection of light stimulus involved in sensory perception (GO:0050962)3.09806402
61detection of light stimulus involved in visual perception (GO:0050908)3.09806402
62NLS-bearing protein import into nucleus (GO:0006607)3.09754614
63regulation of establishment of cell polarity (GO:2000114)3.08627646
64striatum development (GO:0021756)3.04911325
65regulation of granulocyte differentiation (GO:0030852)3.03492284
66behavioral response to nicotine (GO:0035095)2.96728406
67nucleoside transmembrane transport (GO:1901642)2.95111357
68nucleus localization (GO:0051647)2.92874087
69snRNA transcription (GO:0009301)2.92613786
70T cell mediated immunity (GO:0002456)2.92530127
71innate immune response in mucosa (GO:0002227)2.91703980
72positive regulation of developmental pigmentation (GO:0048087)2.91271478
73negative regulation of calcium ion transport into cytosol (GO:0010523)2.87639519
74negative regulation of acute inflammatory response (GO:0002674)2.86222852
75positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.84922404
76mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.84922404
77genitalia morphogenesis (GO:0035112)2.81932654
78pharyngeal system development (GO:0060037)2.81151660
79response to mercury ion (GO:0046689)2.80528577
80positive regulation of chemokine biosynthetic process (GO:0045080)2.77512473
81monoubiquitinated protein deubiquitination (GO:0035520)2.77402781
82negative regulation of neurological system process (GO:0031645)2.76296885
83response to inactivity (GO:0014854)2.75994600
84CD4-positive, alpha-beta T cell activation (GO:0035710)2.75483791
85corticosteroid receptor signaling pathway (GO:0031958)2.75294059
86protein K48-linked deubiquitination (GO:0071108)2.74751379
87spermatid nucleus differentiation (GO:0007289)2.73983479
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.73610415
89regulation of translation, ncRNA-mediated (GO:0045974)2.73610415
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73610415
91nuclear pore complex assembly (GO:0051292)2.73075934
92positive regulation of DNA-templated transcription, initiation (GO:2000144)2.71232709
93tryptophan metabolic process (GO:0006568)2.67972140
94regulation of establishment or maintenance of cell polarity (GO:0032878)2.67697182
95nuclear pore organization (GO:0006999)2.65506536
96cytokine metabolic process (GO:0042107)2.65447547
97regulation of heat generation (GO:0031650)2.64512303
98ether lipid metabolic process (GO:0046485)2.62989899
99regulation of MHC class I biosynthetic process (GO:0045343)2.62578177
100intestinal cholesterol absorption (GO:0030299)2.60681410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.91004037
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.73262082
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16398134
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.61637752
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73543677
6ZNF274_21170338_ChIP-Seq_K562_Hela2.56014963
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.51170115
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34537416
9GBX2_23144817_ChIP-Seq_PC3_Human2.27382944
10ER_23166858_ChIP-Seq_MCF-7_Human2.24797692
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.18004556
12STAT3_23295773_ChIP-Seq_U87_Human1.99883928
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92375786
14TAF15_26573619_Chip-Seq_HEK293_Human1.90855730
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86412490
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.84270303
17TP53_16413492_ChIP-PET_HCT116_Human1.79091351
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.77044154
19FUS_26573619_Chip-Seq_HEK293_Human1.76299897
20NR3C1_21868756_ChIP-Seq_MCF10A_Human1.76227059
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.73354462
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72198599
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71078142
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.67035121
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58360160
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57406020
27BCAT_22108803_ChIP-Seq_LS180_Human1.55039146
28EWS_26573619_Chip-Seq_HEK293_Human1.54706830
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54683599
30TCF4_23295773_ChIP-Seq_U87_Human1.54546746
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53501013
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51521240
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.51268628
34AR_21572438_ChIP-Seq_LNCaP_Human1.47397612
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.47370539
36AHR_22903824_ChIP-Seq_MCF-7_Human1.46745029
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46674248
38AR_25329375_ChIP-Seq_VCAP_Human1.45681760
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.44676414
40SMAD4_21799915_ChIP-Seq_A2780_Human1.43172107
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42779731
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42400754
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42124621
44RXR_22108803_ChIP-Seq_LS180_Human1.41203809
45TCF4_22108803_ChIP-Seq_LS180_Human1.41179785
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39463799
47CBP_20019798_ChIP-Seq_JUKART_Human1.39463799
48P300_19829295_ChIP-Seq_ESCs_Human1.39280951
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36150557
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.35581839
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31378870
52VDR_22108803_ChIP-Seq_LS180_Human1.29599860
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.28712657
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.28684352
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28239344
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28181569
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27949332
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.27948639
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24261713
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.23777850
61IRF1_19129219_ChIP-ChIP_H3396_Human1.22714408
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19374682
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.17324796
64SCL_19346495_ChIP-Seq_HPC-7_Human1.16799962
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16101617
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15084606
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13368193
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13249230
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.12345977
70RUNX2_22187159_ChIP-Seq_PCA_Human1.12274512
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10923359
72TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07598751
73TP53_18474530_ChIP-ChIP_U2OS_Human1.07170024
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05832814
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05696142
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05566738
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05566738
78TBL1_22424771_ChIP-Seq_293T_Human1.04821996
79RUNX_20019798_ChIP-Seq_JUKART_Human1.04633329
80DROSHA_22980978_ChIP-Seq_HELA_Human1.03712944
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03294151
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.03229786
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.02548038
84NANOG_19829295_ChIP-Seq_ESCs_Human1.02131246
85SOX2_19829295_ChIP-Seq_ESCs_Human1.02131246
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01384965
87P53_22387025_ChIP-Seq_ESCs_Mouse1.00619515
88ETV1_20927104_ChIP-Seq_GIST48_Human1.00005188
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99426185
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99243841
91VDR_24787735_ChIP-Seq_THP-1_Human0.98519964
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98302889
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.97579621
94SOX2_18555785_Chip-Seq_ESCs_Mouse0.97391139
95BRD4_25478319_ChIP-Seq_HGPS_Human0.96854904
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96404423
97P300_18555785_Chip-Seq_ESCs_Mouse0.95711486
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95645885
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94540841
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.94422388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.19513017
2MP0001348_abnormal_lacrimal_gland4.67002473
3MP0002822_catalepsy4.54131462
4MP0008057_abnormal_DNA_replication4.35500735
5MP0001873_stomach_inflammation4.24095750
6MP0010030_abnormal_orbit_morphology3.97369475
7MP0005670_abnormal_white_adipose3.73380234
8MP0002009_preneoplasia2.80893883
9MP0005248_abnormal_Harderian_gland2.78566953
10MP0001986_abnormal_taste_sensitivity2.48547121
11MP0005310_abnormal_salivary_gland2.41740272
12MP0005410_abnormal_fertilization1.94056351
13MP0003718_maternal_effect1.90583144
14MP0005174_abnormal_tail_pigmentation1.87333083
15MP0000427_abnormal_hair_cycle1.83173012
16MP0006082_CNS_inflammation1.76315261
17MP0003763_abnormal_thymus_physiology1.73252359
18MP0004142_abnormal_muscle_tone1.65520776
19MP0003656_abnormal_erythrocyte_physiolo1.62400149
20MP0008875_abnormal_xenobiotic_pharmacok1.62113556
21MP0005266_abnormal_metabolism1.60801488
22MP0000371_diluted_coat_color1.47524310
23MP0005083_abnormal_biliary_tract1.45752041
24MP0005365_abnormal_bile_salt1.45127200
25MP0001879_abnormal_lymphatic_vessel1.44085061
26MP0005075_abnormal_melanosome_morpholog1.44013257
27MP0008877_abnormal_DNA_methylation1.41421658
28MP0008995_early_reproductive_senescence1.40979631
29MP0006054_spinal_hemorrhage1.40884912
30MP0008961_abnormal_basal_metabolism1.37160030
31MP0003195_calcinosis1.33455988
32MP0000534_abnormal_ureter_morphology1.31583105
33MP0005551_abnormal_eye_electrophysiolog1.25327248
34MP0001984_abnormal_olfaction1.24793096
35MP0005085_abnormal_gallbladder_physiolo1.22119872
36MP0010329_abnormal_lipoprotein_level1.21966614
37MP0003252_abnormal_bile_duct1.16778886
38MP0000647_abnormal_sebaceous_gland1.16442689
39MP0004742_abnormal_vestibular_system1.15204552
40MP0009840_abnormal_foam_cell1.13848728
41MP0001835_abnormal_antigen_presentation1.06707989
42MP0004130_abnormal_muscle_cell1.04895250
43MP0009115_abnormal_fat_cell1.04687501
44MP0005253_abnormal_eye_physiology1.04635137
45MP0001501_abnormal_sleep_pattern1.04143792
46MP0004381_abnormal_hair_follicle0.98263758
47MP0002166_altered_tumor_susceptibility0.96274904
48MP0005395_other_phenotype0.92294505
49MP0008872_abnormal_physiological_respon0.89756214
50MP0004084_abnormal_cardiac_muscle0.88607853
51MP0000383_abnormal_hair_follicle0.87168836
52MP0005666_abnormal_adipose_tissue0.86842791
53MP0003880_abnormal_central_pattern0.86500828
54MP0002876_abnormal_thyroid_physiology0.85063881
55MP0003959_abnormal_lean_body0.84574926
56MP0004808_abnormal_hematopoietic_stem0.83913134
57MP0001929_abnormal_gametogenesis0.81453777
58MP0003698_abnormal_male_reproductive0.81318452
59MP0005448_abnormal_energy_balance0.80448868
60MP0003943_abnormal_hepatobiliary_system0.79923160
61MP0004484_altered_response_of0.79874004
62MP0005595_abnormal_vascular_smooth0.78582563
63MP0005076_abnormal_cell_differentiation0.77039158
64MP0000470_abnormal_stomach_morphology0.76697453
65MP0002332_abnormal_exercise_endurance0.76293948
66MP0004885_abnormal_endolymph0.76166086
67MP0002282_abnormal_trachea_morphology0.74693235
68MP0006072_abnormal_retinal_apoptosis0.74308906
69MP0002751_abnormal_autonomic_nervous0.73535004
70MP0001286_abnormal_eye_development0.72228054
71MP0009278_abnormal_bone_marrow0.70281785
72MP0003221_abnormal_cardiomyocyte_apopto0.69644378
73MP0005376_homeostasis/metabolism_phenot0.69500903
74MP0003868_abnormal_feces_composition0.68744267
75MP0010368_abnormal_lymphatic_system0.63747362
76MP0002075_abnormal_coat/hair_pigmentati0.63063378
77MP0003699_abnormal_female_reproductive0.62940524
78MP0004036_abnormal_muscle_relaxation0.61715536
79MP0002210_abnormal_sex_determination0.61703377
80MP0008775_abnormal_heart_ventricle0.60900174
81MP0001502_abnormal_circadian_rhythm0.59803497
82MP0000230_abnormal_systemic_arterial0.59211844
83MP0003786_premature_aging0.58891921
84MP0004264_abnormal_extraembryonic_tissu0.58567386
85MP0003632_abnormal_nervous_system0.58119315
86MP0008004_abnormal_stomach_pH0.57427347
87MP0000613_abnormal_salivary_gland0.56785748
88MP0001661_extended_life_span0.56182236
89MP0004134_abnormal_chest_morphology0.55508829
90MP0001800_abnormal_humoral_immune0.54154722
91MP0008770_decreased_survivor_rate0.52853426
92MP0006138_congestive_heart_failure0.52819021
93MP0005197_abnormal_uvea_morphology0.52743602
94MP0003567_abnormal_fetal_cardiomyocyte0.49920926
95MP0005375_adipose_tissue_phenotype0.49352302
96MP0003045_fibrosis0.49323432
97MP0002932_abnormal_joint_morphology0.48126824
98MP0006276_abnormal_autonomic_nervous0.46925552
99MP0000516_abnormal_urinary_system0.46883327
100MP0005367_renal/urinary_system_phenotyp0.46883327

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)5.17173211
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.87058673
3Short 1st metacarpal (HP:0010034)4.87058673
4Short phalanx of the thumb (HP:0009660)4.84971207
5Bicornuate uterus (HP:0000813)4.58149634
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.49273354
7Abnormality of the 1st metacarpal (HP:0010009)4.18365149
8Long clavicles (HP:0000890)3.96107530
9Chronic hepatic failure (HP:0100626)3.86042639
10Hepatoblastoma (HP:0002884)3.81997314
11Aplasia/Hypoplasia of the sternum (HP:0006714)3.77968312
12Abnormal pancreas size (HP:0012094)3.76663286
13Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.63687824
14Annular pancreas (HP:0001734)3.62798952
15Fair hair (HP:0002286)3.51604471
16Hyperventilation (HP:0002883)3.51136497
17Decreased lacrimation (HP:0000633)3.47411853
18Alacrima (HP:0000522)3.40187052
19Hypoplastic nipples (HP:0002557)3.31317617
20Abnormality of the pubic bones (HP:0003172)3.30083747
21Broad ribs (HP:0000885)3.16903618
22Hypoplastic labia majora (HP:0000059)3.15378913
23Large for gestational age (HP:0001520)3.13405478
24Abnormality of the labia majora (HP:0012881)3.10172453
25Facial hemangioma (HP:0000329)3.01596897
26Absent speech (HP:0001344)2.98267389
27Generalized hypopigmentation of hair (HP:0011358)2.96681756
28Abnormality of the fingertips (HP:0001211)2.72965608
29Abnormality of the nasal septum (HP:0000419)2.68118850
30Germ cell neoplasia (HP:0100728)2.66122405
31Abnormality of the labia minora (HP:0012880)2.64212137
32Abnormality of the renal cortex (HP:0011035)2.62139504
33Inability to walk (HP:0002540)2.57333915
34Protruding tongue (HP:0010808)2.48350413
35Ureteral stenosis (HP:0000071)2.42214972
36Poikilocytosis (HP:0004447)2.34833438
37Ureteral obstruction (HP:0006000)2.29186380
38Acanthocytosis (HP:0001927)2.28919481
39Abnormality of the sella turcica (HP:0002679)2.28836360
40Neoplasm of the heart (HP:0100544)2.28260783
41Macroglossia (HP:0000158)2.27365810
42Short 4th metacarpal (HP:0010044)2.26063488
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26063488
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22340205
45Attenuation of retinal blood vessels (HP:0007843)2.21957414
46Deformed sella turcica (HP:0002681)2.21834774
47Widely patent fontanelles and sutures (HP:0004492)2.21696343
48Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.18687413
49Opisthotonus (HP:0002179)2.14596629
50Progressive cerebellar ataxia (HP:0002073)2.13377229
51Pancreatic cysts (HP:0001737)2.10818009
52Abnormality of the pons (HP:0007361)2.09832088
53Anterior segment dysgenesis (HP:0007700)2.09387996
54Submucous cleft hard palate (HP:0000176)2.05137393
55Truncal obesity (HP:0001956)2.04315730
56Short foot (HP:0001773)2.02340100
57Adactyly (HP:0009776)2.00982221
58Broad nasal tip (HP:0000455)1.99654376
59Decreased skull ossification (HP:0004331)1.97407115
60Tapered finger (HP:0001182)1.96910939
61Hypoplasia of the pons (HP:0012110)1.96680083
62Prominent forehead (HP:0011220)1.95660877
63Entropion (HP:0000621)1.94728790
64Gaze-evoked nystagmus (HP:0000640)1.94139598
65Hydroureter (HP:0000072)1.93783555
66Hypobetalipoproteinemia (HP:0003563)1.91677255
67Prominent nose (HP:0000448)1.90497974
68Abnormality of macular pigmentation (HP:0008002)1.90098263
69Partial agenesis of the corpus callosum (HP:0001338)1.86206921
70Bony spicule pigmentary retinopathy (HP:0007737)1.84509137
71Relative macrocephaly (HP:0004482)1.83669507
72Cerebellar dysplasia (HP:0007033)1.80874275
73Stomatitis (HP:0010280)1.80714884
74Congenital stationary night blindness (HP:0007642)1.77037124
75Clumsiness (HP:0002312)1.76204821
76Anophthalmia (HP:0000528)1.76160686
77Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.74815876
78Thyroiditis (HP:0100646)1.74550031
79Short distal phalanx of finger (HP:0009882)1.74056998
80Labial hypoplasia (HP:0000066)1.71856949
81Genetic anticipation (HP:0003743)1.71435074
82Stomach cancer (HP:0012126)1.70069820
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.69634462
84Abnormality of the renal medulla (HP:0100957)1.69219373
85Hypoplastic iliac wings (HP:0002866)1.68765272
86Abnormal auditory evoked potentials (HP:0006958)1.67718266
87Aplasia/Hypoplasia of the hallux (HP:0008362)1.67356484
88Sparse lateral eyebrow (HP:0005338)1.66503759
89Anteriorly placed anus (HP:0001545)1.66121801
90Tubular atrophy (HP:0000092)1.64974411
91Narrow palate (HP:0000189)1.64167353
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63842974
93Visual hallucinations (HP:0002367)1.63182329
94Congenital sensorineural hearing impairment (HP:0008527)1.63077443
95Widely spaced teeth (HP:0000687)1.62837687
96Impulsivity (HP:0100710)1.62755914
97Long nose (HP:0003189)1.62147624
98Neurodegeneration (HP:0002180)1.60500150
99Heterotopia (HP:0002282)1.60283857
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.59173238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.07040116
2FRK4.43856205
3PBK4.28010675
4CAMK1D3.24212282
5PIK3CG3.19149280
6MAP4K23.18819597
7CAMK1G2.96203332
8AKT32.91966933
9BRD42.79288187
10CAMKK22.28191820
11ZAK2.22596567
12PDK22.09910033
13BRSK21.95943963
14TNIK1.90319172
15ACVR1B1.85983005
16STK38L1.80752214
17SIK21.66930964
18MARK31.60599608
19CDK121.55500849
20EEF2K1.54240787
21NEK61.43961399
22TLK11.36901888
23WNK11.30286606
24MAPK131.28047921
25TRPM71.25352650
26KSR11.20296383
27TAOK31.13878124
28NLK1.09891828
29PTK2B1.09269352
30CASK1.08381438
31PIM11.05129975
32DYRK1B0.98989129
33CDK60.97775207
34MST40.97344276
35NEK90.95641439
36STK240.95532952
37MKNK20.95193096
38MAPK110.91830890
39TYRO30.87460053
40STK40.85482296
41STK390.82945785
42PRKAA20.79631172
43TEC0.77808792
44ITK0.77607721
45WNK40.74998870
46FLT30.74403600
47MET0.73594025
48MKNK10.73426990
49BMPR1B0.71942406
50MAP3K70.70937828
51CHUK0.69109862
52CAMKK10.68369510
53CAMK40.66820236
54SGK20.64747297
55ADRBK20.63602619
56PDGFRB0.63018760
57MELK0.62323884
58PRKAA10.60760029
59STK110.60559723
60SGK30.58950661
61YES10.52423889
62RPS6KB20.51556298
63NME10.51525716
64TGFBR10.51305043
65PIK3CA0.51161374
66IKBKB0.50583218
67CDK40.49296493
68BTK0.49007696
69PDK10.46719294
70PNCK0.45728258
71TXK0.43688732
72FGFR30.42016086
73SGK4940.41970660
74SGK2230.41970660
75CSNK1D0.41826404
76GRK10.40432977
77SIK30.39663848
78STK30.39150147
79MTOR0.37039835
80ERBB20.34315761
81SGK10.32931519
82CAMK10.31269248
83LCK0.30905267
84PDPK10.29948617
85GSK3B0.29663731
86MYLK0.28651267
87MAPK100.27836133
88OXSR10.27529191
89MAPK80.26838128
90ATM0.26581803
91PRKCZ0.26415140
92RPS6KA50.25422974
93OBSCN0.24803543
94MAPK150.24671396
95MAPK10.24406692
96ABL10.24029262
97MARK20.23521757
98MAPK140.21971843
99TNK20.21248006
100CSNK1A10.20869616

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.80065153
2Fatty acid biosynthesis_Homo sapiens_hsa000612.57218000
3Asthma_Homo sapiens_hsa053102.43985595
4Non-homologous end-joining_Homo sapiens_hsa034502.26960811
5Autoimmune thyroid disease_Homo sapiens_hsa053202.02849657
6Butanoate metabolism_Homo sapiens_hsa006502.02391115
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.92220082
8Lysine degradation_Homo sapiens_hsa003101.89967872
9ABC transporters_Homo sapiens_hsa020101.86017973
10Allograft rejection_Homo sapiens_hsa053301.79072979
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77344969
12Taste transduction_Homo sapiens_hsa047421.72310267
13Phototransduction_Homo sapiens_hsa047441.64859849
14Nitrogen metabolism_Homo sapiens_hsa009101.63708194
15Circadian rhythm_Homo sapiens_hsa047101.51920553
16Non-small cell lung cancer_Homo sapiens_hsa052231.51031899
17Small cell lung cancer_Homo sapiens_hsa052221.49959012
18T cell receptor signaling pathway_Homo sapiens_hsa046601.46107345
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43453103
20TGF-beta signaling pathway_Homo sapiens_hsa043501.40240775
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35586896
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31867039
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.28427380
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27374279
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25657796
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19511610
27RNA polymerase_Homo sapiens_hsa030201.19240245
28Inositol phosphate metabolism_Homo sapiens_hsa005621.15154437
29Linoleic acid metabolism_Homo sapiens_hsa005911.14285338
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13884725
31Dorso-ventral axis formation_Homo sapiens_hsa043201.13632664
32Calcium signaling pathway_Homo sapiens_hsa040201.12004244
33Cocaine addiction_Homo sapiens_hsa050301.11131168
34Tryptophan metabolism_Homo sapiens_hsa003801.09971948
35Ovarian steroidogenesis_Homo sapiens_hsa049131.04938610
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02594539
37Systemic lupus erythematosus_Homo sapiens_hsa053221.02441781
38Sphingolipid metabolism_Homo sapiens_hsa006001.01748320
39Platelet activation_Homo sapiens_hsa046110.99571019
40Vitamin digestion and absorption_Homo sapiens_hsa049770.98748893
41Salivary secretion_Homo sapiens_hsa049700.96926826
42Alcoholism_Homo sapiens_hsa050340.94855977
43Fat digestion and absorption_Homo sapiens_hsa049750.94212268
44Viral carcinogenesis_Homo sapiens_hsa052030.93232538
45Hematopoietic cell lineage_Homo sapiens_hsa046400.88487108
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.88161128
47Ether lipid metabolism_Homo sapiens_hsa005650.86880453
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86196412
49mTOR signaling pathway_Homo sapiens_hsa041500.83805242
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81833200
51FoxO signaling pathway_Homo sapiens_hsa040680.76680461
52Cholinergic synapse_Homo sapiens_hsa047250.76517131
53Morphine addiction_Homo sapiens_hsa050320.75638646
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73235602
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72291333
56Glutamatergic synapse_Homo sapiens_hsa047240.72281400
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70238914
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69215796
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.68684048
60MicroRNAs in cancer_Homo sapiens_hsa052060.67290637
61Caffeine metabolism_Homo sapiens_hsa002320.65831568
62Serotonergic synapse_Homo sapiens_hsa047260.64454594
63Glycerolipid metabolism_Homo sapiens_hsa005610.64354104
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64199288
65Thyroid hormone synthesis_Homo sapiens_hsa049180.63797416
66Measles_Homo sapiens_hsa051620.62474917
67Type II diabetes mellitus_Homo sapiens_hsa049300.61553564
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60636314
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59486931
70Complement and coagulation cascades_Homo sapiens_hsa046100.59087309
71Chemical carcinogenesis_Homo sapiens_hsa052040.58766695
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57802938
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53831964
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52927482
75Pathways in cancer_Homo sapiens_hsa052000.52742067
76Hedgehog signaling pathway_Homo sapiens_hsa043400.52258183
77Nicotine addiction_Homo sapiens_hsa050330.51685160
78Glucagon signaling pathway_Homo sapiens_hsa049220.51651802
79Rap1 signaling pathway_Homo sapiens_hsa040150.51337238
80AMPK signaling pathway_Homo sapiens_hsa041520.50178398
81Olfactory transduction_Homo sapiens_hsa047400.49997923
82Selenocompound metabolism_Homo sapiens_hsa004500.49446106
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48729388
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48433694
85Renal cell carcinoma_Homo sapiens_hsa052110.45965359
86Chronic myeloid leukemia_Homo sapiens_hsa052200.45212178
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45183471
88Axon guidance_Homo sapiens_hsa043600.44843669
89Prostate cancer_Homo sapiens_hsa052150.44704442
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43824982
91TNF signaling pathway_Homo sapiens_hsa046680.43206333
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42266790
93Propanoate metabolism_Homo sapiens_hsa006400.41884488
94Insulin resistance_Homo sapiens_hsa049310.41192562
95Estrogen signaling pathway_Homo sapiens_hsa049150.41110029
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.39621229
97PPAR signaling pathway_Homo sapiens_hsa033200.38355524
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36634334
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.35540452
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35098037

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