ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of uterine smooth muscle contraction (GO:0070474)	8.94972682
2	actin filament depolymerization (GO:0030042)	8.41472860
3	cellular zinc ion homeostasis (GO:0006882)	8.07361291
4	positive regulation of gamma-delta T cell activation (GO:0046645)	7.64258439
5	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	7.61240923
6	regulation of uterine smooth muscle contraction (GO:0070472)	7.03933794
7	zinc ion homeostasis (GO:0055069)	6.65387388
8	regulation of gamma-delta T cell differentiation (GO:0045586)	6.38493615
9	monoubiquitinated protein deubiquitination (GO:0035520)	6.23554164
10	cell migration involved in gastrulation (GO:0042074)	6.21956932
11	fucosylation (GO:0036065)	5.82521911
12	protein K11-linked deubiquitination (GO:0035871)	5.75046701
13	basement membrane organization (GO:0071711)	5.69555063
14	organelle membrane fusion (GO:0090174)	5.69469881
15	protein carboxylation (GO:0018214)	5.65501939
16	peptidyl-glutamic acid carboxylation (GO:0017187)	5.65501939
17	positive regulation of gluconeogenesis (GO:0045722)	5.64332818
18	cell proliferation in forebrain (GO:0021846)	5.60611472
19	regulation of gamma-delta T cell activation (GO:0046643)	5.58109151
20	regulation of developmental pigmentation (GO:0048070)	5.39528985
21	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.35471847
22	cellular response to lithium ion (GO:0071285)	5.13609554
23	endosome to melanosome transport (GO:0035646)	5.01562596
24	endosome to pigment granule transport (GO:0043485)	5.01562596
25	fat-soluble vitamin biosynthetic process (GO:0042362)	4.90096868
26	protein K48-linked deubiquitination (GO:0071108)	4.88383335
27	lysosome localization (GO:0032418)	4.83957222
28	response to lipoprotein particle (GO:0055094)	4.77829096
29	lens fiber cell development (GO:0070307)	4.77665137
30	regulation of T cell receptor signaling pathway (GO:0050856)	4.72938171
31	RNA destabilization (GO:0050779)	4.51523013
32	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	4.45410742
33	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.43791744
34	antigen processing and presentation via MHC class Ib (GO:0002475)	4.42949480
35	cerebellar granule cell differentiation (GO:0021707)	4.38474648
36	melanosome localization (GO:0032400)	4.37421414
37	positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)	4.37338420
38	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	4.25827241
39	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	4.23943795
40	pigment granule localization (GO:0051875)	4.15164032
41	negative regulation of T cell differentiation in thymus (GO:0033085)	4.13072617
42	nuclear envelope reassembly (GO:0031468)	4.12282923
43	mitotic nuclear envelope reassembly (GO:0007084)	4.12282923
44	negative regulation of toll-like receptor signaling pathway (GO:0034122)	4.06678902
45	mitochondrion morphogenesis (GO:0070584)	3.99760153
46	N-acetylglucosamine metabolic process (GO:0006044)	3.95692904
47	negative regulation of macrophage differentiation (GO:0045650)	3.84262394
48	cellular response to nitric oxide (GO:0071732)	3.75913891
49	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	3.69939374
50	positive regulation of smooth muscle contraction (GO:0045987)	3.58134285
51	negative regulation of T cell apoptotic process (GO:0070233)	3.58085385
52	sex differentiation (GO:0007548)	3.57820294
53	vitamin biosynthetic process (GO:0009110)	3.56461491
54	regulation of energy homeostasis (GO:2000505)	3.55793484
55	regulation of germinal center formation (GO:0002634)	3.55285016
56	regulation of toll-like receptor signaling pathway (GO:0034121)	3.52280991
57	protein targeting to lysosome (GO:0006622)	3.49739540
58	establishment of protein localization to vacuole (GO:0072666)	3.49739540
59	protein targeting to vacuole (GO:0006623)	3.49739540
60	negative regulation of thymocyte apoptotic process (GO:0070244)	3.46273830
61	vitamin D metabolic process (GO:0042359)	3.45796970
62	purine deoxyribonucleotide catabolic process (GO:0009155)	3.41958462
63	regulation of defense response to virus by virus (GO:0050690)	3.41418617
64	regulation of B cell apoptotic process (GO:0002902)	3.41017302
65	regulation of T cell differentiation in thymus (GO:0033081)	3.40581453
66	mitochondrial fusion (GO:0008053)	3.32433412
67	protein localization to vacuole (GO:0072665)	3.32208017
68	protein localization to lysosome (GO:0061462)	3.32208017
69	melanosome organization (GO:0032438)	3.31760684
70	protein neddylation (GO:0045116)	3.31600405
71	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.29235637
72	protein K63-linked deubiquitination (GO:0070536)	3.22622421
73	negative regulation of DNA repair (GO:0045738)	3.16345682
74	terpenoid biosynthetic process (GO:0016114)	3.15484458
75	somite development (GO:0061053)	3.12264922
76	virion attachment to host cell (GO:0019062)	3.11906814
77	adhesion of symbiont to host cell (GO:0044650)	3.11906814
78	pigment granule organization (GO:0048753)	3.11011878
79	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.10492156
80	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.08312019
81	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.07606857
82	regulation of penile erection (GO:0060405)	3.06757916
83	negative regulation of circadian rhythm (GO:0042754)	3.06665097
84	positive regulation of T cell differentiation in thymus (GO:0033089)	3.05950828
85	positive regulation of defense response to virus by host (GO:0002230)	3.04835161
86	negative regulation of mast cell activation (GO:0033004)	3.04256072
87	platelet formation (GO:0030220)	2.99203474
88	negative regulation of telomerase activity (GO:0051974)	2.98551717
89	negative regulation of B cell apoptotic process (GO:0002903)	2.91831516
90	succinate metabolic process (GO:0006105)	2.90460386
91	negative regulation of lipid storage (GO:0010888)	2.90405275
92	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.89481916
93	protein depolymerization (GO:0051261)	2.86099976
94	interferon-gamma production (GO:0032609)	2.86006450
95	L-fucose catabolic process (GO:0042355)	2.84883665
96	fucose catabolic process (GO:0019317)	2.84883665
97	L-fucose metabolic process (GO:0042354)	2.84883665
98	cellular response to ATP (GO:0071318)	2.84521284
99	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.83443435
100	tolerance induction (GO:0002507)	12.1519741

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.89547995
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.46039852
3	IRF1_19129219_ChIP-ChIP_H3396_Human	3.42537507
4	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.90517784
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47578708
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.45400865
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.23347941
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.20875909
9	FOXA1_27270436_Chip-Seq_PROSTATE_Human	2.19749531
10	FOXA1_25329375_ChIP-Seq_VCAP_Human	2.19749531
11	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.14312049
12	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.94103585
13	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.92825388
14	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.89054811
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86421804
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.85273892
17	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.78757570
18	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.76991317
19	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.76793927
20	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72816368
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.71701668
22	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.70377186
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.60242977
24	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.54444085
25	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.53161074
26	VDR_22108803_ChIP-Seq_LS180_Human	1.49351025
27	RXR_22108803_ChIP-Seq_LS180_Human	1.48832531
28	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.48182291
29	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.47899021
30	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.47505454
31	TAF2_19829295_ChIP-Seq_ESCs_Human	1.47291289
32	TP53_16413492_ChIP-PET_HCT116_Human	1.46813716
33	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.46161106
34	STAT1_20625510_ChIP-Seq_HELA_Human	1.44633229
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.42955466
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42219351
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.42174822
38	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.41840286
39	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.40683370
40	CBP_21632823_ChIP-Seq_H3396_Human	1.38656960
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.36084518
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35781687
43	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33360090
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33182609
45	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32124022
46	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.31213525
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29662084
48	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23820527
49	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.23746917
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22496757
51	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.20410634
52	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.19686995
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19183089
54	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.17018256
55	ERG_20517297_ChIP-Seq_VCAP_Human	1.14743516
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14608328
57	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12234204
58	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.12209516
59	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12194412
60	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.10602407
61	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.09575637
62	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.08852138
63	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08812182
64	SMAD4_21741376_ChIP-Seq_ESCs_Human	1.08678540
65	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07559193
66	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05021086
67	AR_21572438_ChIP-Seq_LNCaP_Human	1.04652675
68	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03975087
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03936002
70	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.02510323
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.00371962
72	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.00094150
73	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98992118
74	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98144276
75	SA1_27219007_Chip-Seq_Bcells_Human	0.96279343
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95209337
77	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.95116083
78	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.94249711
79	AR_20517297_ChIP-Seq_VCAP_Human	0.92567393
80	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91765103
81	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.91570418
82	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.91143497
83	REST_21632747_ChIP-Seq_MESCs_Mouse	0.90372643
84	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.89323155
85	ERA_21632823_ChIP-Seq_H3396_Human	0.88015875
86	TP53_22573176_ChIP-Seq_HFKS_Human	0.87441219
87	RAC3_21632823_ChIP-Seq_H3396_Human	0.87261712
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.86932897
89	TCF4_23295773_ChIP-Seq_U87_Human	0.86926212
90	FOXP3_21729870_ChIP-Seq_TREG_Human	0.86490551
91	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.86397383
92	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.86397383
93	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.86397383
94	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.86301621
95	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.85284055
96	FUS_26573619_Chip-Seq_HEK293_Human	0.84803639
97	SCL_19346495_ChIP-Seq_HPC-7_Human	0.84571422
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.82997505
99	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.82983381
100	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.82839973

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005075_abnormal_melanosome_morpholog	7.41887287
2	MP0005408_hypopigmentation	6.85937050
3	MP0000569_abnormal_digit_pigmentation	5.53399430
4	MP0005174_abnormal_tail_pigmentation	4.08046378
5	MP0000015_abnormal_ear_pigmentation	3.38933913
6	MP0000371_diluted_coat_color	3.38839267
7	MP0008007_abnormal_cellular_replicative	3.13212326
8	MP0000566_synostosis	3.03894034
9	MP0010234_abnormal_vibrissa_follicle	2.92164217
10	MP0005670_abnormal_white_adipose	2.63535611
11	MP0009053_abnormal_anal_canal	2.55319694
12	MP0005646_abnormal_pituitary_gland	2.54570301
13	MP0002653_abnormal_ependyma_morphology	2.47501874
14	MP0009697_abnormal_copulation	2.35787472
15	MP0003172_abnormal_lysosome_physiology	2.25452380
16	MP0000013_abnormal_adipose_tissue	2.17013764
17	MP0004130_abnormal_muscle_cell	2.15342151
18	MP0003890_abnormal_embryonic-extraembry	2.11975166
19	MP0001919_abnormal_reproductive_system	2.09252306
20	MP0001661_extended_life_span	2.06608134
21	MP0000537_abnormal_urethra_morphology	2.01250934
22	MP0001324_abnormal_eye_pigmentation	1.93631270
23	MP0001293_anophthalmia	1.74129551
24	MP0003119_abnormal_digestive_system	1.73654391
25	MP0003763_abnormal_thymus_physiology	1.69403065
26	MP0002075_abnormal_coat/hair_pigmentati	1.68824551
27	MP0002095_abnormal_skin_pigmentation	1.55333173
28	MP0002938_white_spotting	1.54238889
29	MP0005389_reproductive_system_phenotype	1.51107120
30	MP0002254_reproductive_system_inflammat	1.47699093
31	MP0003011_delayed_dark_adaptation	1.40713640
32	MP0010678_abnormal_skin_adnexa	1.37888186
33	MP0006035_abnormal_mitochondrial_morpho	1.37506820
34	MP0004885_abnormal_endolymph	1.35521379
35	MP0000049_abnormal_middle_ear	1.32157278
36	MP0005197_abnormal_uvea_morphology	1.30699171
37	MP0008875_abnormal_xenobiotic_pharmacok	1.30513278
38	MP0002138_abnormal_hepatobiliary_system	1.28879372
39	MP0002837_dystrophic_cardiac_calcinosis	1.23327725
40	MP0003724_increased_susceptibility_to	1.21550760
41	MP0003937_abnormal_limbs/digits/tail_de	1.20341079
42	MP0003950_abnormal_plasma_membrane	1.20030133
43	MP0002876_abnormal_thyroid_physiology	1.18529988
44	MP0005464_abnormal_platelet_physiology	1.16168808
45	MP0002102_abnormal_ear_morphology	1.16137203
46	MP0001186_pigmentation_phenotype	1.13410868
47	MP0004185_abnormal_adipocyte_glucose	1.11941565
48	MP0006036_abnormal_mitochondrial_physio	1.04670508
49	MP0003252_abnormal_bile_duct	1.04206450
50	MP0001968_abnormal_touch/_nociception	1.03413396
51	MP0008872_abnormal_physiological_respon	1.01637320
52	MP0001944_abnormal_pancreas_morphology	1.00665429
53	MP0003315_abnormal_perineum_morphology	0.94467139
54	MP0001485_abnormal_pinna_reflex	0.93652895
55	MP0009780_abnormal_chondrocyte_physiolo	0.86707720
56	MP0000383_abnormal_hair_follicle	0.86620367
57	MP0003938_abnormal_ear_development	0.85800671
58	MP0000631_abnormal_neuroendocrine_gland	0.82503278
59	MP0002693_abnormal_pancreas_physiology	0.77980909
60	MP0006292_abnormal_olfactory_placode	0.77589960
61	MP0002177_abnormal_outer_ear	0.76985722
62	MP0003646_muscle_fatigue	0.76513822
63	MP0003283_abnormal_digestive_organ	0.75106255
64	MP0002092_abnormal_eye_morphology	0.74990077
65	MP0003693_abnormal_embryo_hatching	0.73854642
66	MP0009046_muscle_twitch	0.73827512
67	MP0000516_abnormal_urinary_system	0.72918023
68	MP0005367_renal/urinary_system_phenotyp	0.72918023
69	MP0000477_abnormal_intestine_morphology	0.72461802
70	MP0001502_abnormal_circadian_rhythm	0.72422407
71	MP0005167_abnormal_blood-brain_barrier	0.70193814
72	MP0004782_abnormal_surfactant_physiolog	0.69133099
73	MP0005391_vision/eye_phenotype	0.63702041
74	MP0000467_abnormal_esophagus_morphology	0.61676021
75	MP0002735_abnormal_chemical_nociception	0.60789031
76	MP0004484_altered_response_of	0.59291877
77	MP0003638_abnormal_response/metabolism_	0.59136715
78	MP0003936_abnormal_reproductive_system	0.58576174
79	MP0009250_abnormal_appendicular_skeleto	0.57998086
80	MP0001119_abnormal_female_reproductive	0.57009111
81	MP0000747_muscle_weakness	0.56774265
82	MP0002160_abnormal_reproductive_system	0.56115835
83	MP0002932_abnormal_joint_morphology	0.55567459
84	MP0002733_abnormal_thermal_nociception	0.54779234
85	MP0003111_abnormal_nucleus_morphology	0.53639639
86	MP0005195_abnormal_posterior_eye	0.53576710
87	MP0000703_abnormal_thymus_morphology	0.52421588
88	MP0001873_stomach_inflammation	0.49926150
89	MP0001177_atelectasis	0.49238248
90	MP0000678_abnormal_parathyroid_gland	0.49193071
91	MP0000003_abnormal_adipose_tissue	0.48761866
92	MP0002736_abnormal_nociception_after	0.47971744
93	MP0001664_abnormal_digestion	0.47259208
94	MP0002136_abnormal_kidney_physiology	0.47149170
95	MP0002282_abnormal_trachea_morphology	0.46066660
96	MP0003718_maternal_effect	0.45132982
97	MP0002064_seizures	0.44464698
98	MP0002184_abnormal_innervation	0.42778395
99	MP0002877_abnormal_melanocyte_morpholog	0.40918077
100	MP0002269_muscular_atrophy	0.40311824

Predicted human phenotypes

Rank	Gene Set	Z-score
1	B lymphocytopenia (HP:0010976)	9.56074289
2	Abnormality of B cell number (HP:0010975)	8.83455523
3	IgM deficiency (HP:0002850)	7.72201656
4	Humeroradial synostosis (HP:0003041)	5.49639080
5	Synostosis involving the elbow (HP:0003938)	5.49639080
6	Oligodactyly (hands) (HP:0001180)	5.05506024
7	Fibular aplasia (HP:0002990)	4.73419006
8	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.52895505
9	Abnormality of alanine metabolism (HP:0010916)	4.52895505
10	Hyperalaninemia (HP:0003348)	4.52895505
11	IgG deficiency (HP:0004315)	4.27465627
12	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.27056010
13	Hypoplastic pelvis (HP:0008839)	4.23523891
14	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	4.12767738
15	Adactyly (HP:0009776)	4.12134117
16	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	4.06888835
17	Radial bowing (HP:0002986)	4.06187840
18	Abnormality of the costochondral junction (HP:0000919)	3.81650565
19	Symphalangism affecting the phalanges of the hand (HP:0009773)	3.71796402
20	Posterior subcapsular cataract (HP:0007787)	3.71287485
21	IgA deficiency (HP:0002720)	3.69816375
22	Albinism (HP:0001022)	3.66611169
23	Split foot (HP:0001839)	3.60425908
24	Abnormal finger flexion creases (HP:0006143)	3.56604457
25	Aplasia/hypoplasia of the uterus (HP:0008684)	3.44440193
26	Oligodactyly (HP:0012165)	3.42496690
27	Gastrointestinal stroma tumor (HP:0100723)	3.38408489
28	Abnormality of T cell physiology (HP:0011840)	3.37998799
29	Thin bony cortex (HP:0002753)	3.22059743
30	Recurrent sinusitis (HP:0011108)	3.16924134
31	Short 1st metacarpal (HP:0010034)	3.08182531
32	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.08182531
33	Recurrent bronchitis (HP:0002837)	3.07899158
34	Neoplasm of head and neck (HP:0012288)	3.03306124
35	Esophageal neoplasm (HP:0100751)	3.03306124
36	Increased intramyocellular lipid droplets (HP:0012240)	2.98637077
37	Delayed epiphyseal ossification (HP:0002663)	2.96185724
38	Femoral bowing (HP:0002980)	2.78898855
39	Abnormality of the peritoneum (HP:0002585)	2.71410185
40	Fused cervical vertebrae (HP:0002949)	2.69823382
41	Autoimmune thrombocytopenia (HP:0001973)	2.69145329
42	Abnormality of the 1st metacarpal (HP:0010009)	2.69091240
43	Gonadotropin excess (HP:0000837)	2.68200674
44	Severe visual impairment (HP:0001141)	2.64486910
45	Enlarged epiphyses (HP:0010580)	2.62430801
46	Abnormality of the pubic bones (HP:0003172)	2.60218113
47	Mesangial abnormality (HP:0001966)	2.59169345
48	Hepatocellular necrosis (HP:0001404)	2.57569272
49	Mediastinal lymphadenopathy (HP:0100721)	2.52046888
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.51989100
51	Increased muscle lipid content (HP:0009058)	2.51359427
52	Bowed forearm bones (HP:0003956)	2.50395010
53	Bowing of the arm (HP:0006488)	2.50395010
54	Elevated erythrocyte sedimentation rate (HP:0003565)	2.43953551
55	Broad ribs (HP:0000885)	2.37477475
56	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.30883166
57	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.30883166
58	Congenital stationary night blindness (HP:0007642)	2.30411511
59	Barrel-shaped chest (HP:0001552)	2.29932593
60	Aplasia involving forearm bones (HP:0009822)	2.23677348
61	Absent forearm bone (HP:0003953)	2.23677348
62	Pustule (HP:0200039)	2.22059937
63	Hypoplastic iliac wings (HP:0002866)	2.21153624
64	Ocular albinism (HP:0001107)	2.20763490
65	Hematochezia (HP:0002573)	2.20201691
66	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.20012944
67	Recurrent pneumonia (HP:0006532)	2.19792235
68	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.19352679
69	Short hallux (HP:0010109)	2.16511359
70	Short phalanx of the thumb (HP:0009660)	2.15853486
71	Mitochondrial inheritance (HP:0001427)	2.15281971
72	Morphological abnormality of the middle ear (HP:0008609)	2.09453710
73	Hypoplasia of the radius (HP:0002984)	2.08773124
74	Skull defect (HP:0001362)	2.08369719
75	Generalized hypopigmentation of hair (HP:0011358)	2.08362009
76	Type II lissencephaly (HP:0007260)	2.06736043
77	Lymphopenia (HP:0001888)	2.06307909
78	Aplasia/hypoplasia of the femur (HP:0005613)	2.05014312
79	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.99020243
80	Bilateral microphthalmos (HP:0007633)	1.98985763
81	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.98541773
82	Increased CSF lactate (HP:0002490)	1.98186634
83	Ragged-red muscle fibers (HP:0003200)	1.96829706
84	Hepatic necrosis (HP:0002605)	1.94886075
85	Stomatitis (HP:0010280)	1.94615923
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.93455992
87	Hypoplasia of the fovea (HP:0007750)	1.93455992
88	Absent toe (HP:0010760)	1.93455736
89	Abnormality of the nasal septum (HP:0000419)	1.89216380
90	Hemivertebrae (HP:0002937)	1.88952634
91	Type 2 muscle fiber atrophy (HP:0003554)	1.87804355
92	Fair hair (HP:0002286)	1.86182460
93	Aplasia/Hypoplasia of the patella (HP:0006498)	1.86153043
94	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.85803837
95	Abnormality of the fibula (HP:0002991)	1.85409804
96	Abnormality of T cells (HP:0002843)	1.85290208
97	Subcapsular cataract (HP:0000523)	1.84602389
98	Hypoplastic nipples (HP:0002557)	1.83882690
99	Iris hypopigmentation (HP:0007730)	1.82689173
100	Patellar aplasia (HP:0006443)	1.81988991

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.95883807
2	ARAF	5.65391341
3	MAP3K13	5.55081085
4	NLK	3.84924742
5	CSNK1G1	3.84029988
6	MAPK11	3.06682938
7	PRKCI	3.03174065
8	GRK1	2.77720963
9	CSNK1G3	2.71098509
10	CSNK1A1L	2.68302868
11	MOS	2.68131019
12	CSK	2.59774451
13	KSR2	2.46588409
14	CSNK1G2	2.29240003
15	BRAF	2.03656927
16	ADRBK2	1.85234333
17	SGK2	1.68390593
18	RAF1	1.50372350
19	ZAK	1.32656163
20	KSR1	1.27454533
21	FGFR2	1.22386045
22	MAP2K1	1.19505007
23	SGK223	1.17844861
24	SGK494	1.17844861
25	ITK	1.16898726
26	SYK	1.15383152
27	SGK3	1.14108338
28	FRK	1.08390970
29	IKBKE	1.05447400
30	TEC	1.03593042
31	WNK4	0.95466755
32	CDK4	0.88743002
33	FGFR4	0.86955325
34	CDC7	0.82997973
35	PRKCG	0.81537789
36	DAPK2	0.76600661
37	TBK1	0.75236532
38	STK39	0.73685915
39	TYRO3	0.68643923
40	ADRBK1	0.67434913
41	ATR	0.66115319
42	BRSK2	0.64402380
43	DYRK1A	0.61054128
44	NTRK2	0.60640329
45	BMPR1B	0.60594447
46	TAOK1	0.60359673
47	LCK	0.59900112
48	JAK3	0.59256904
49	CDK9	0.58171942
50	PAK1	0.53907218
51	TGFBR2	0.52217727
52	PRKCE	0.50180431
53	CHEK2	0.48857836
54	MAP3K1	0.48244583
55	BTK	0.45408184
56	OXSR1	0.43417214
57	ACVR1B	0.43099146
58	MAPK13	0.42324308
59	CSNK1A1	0.42177670
60	CSNK1D	0.41269349
61	MAPK9	0.38038369
62	PRKCA	0.38036067
63	KIT	0.37664614
64	HCK	0.37468045
65	NME1	0.37341082
66	MAP3K8	0.36144206
67	IRAK1	0.33428699
68	PRKCH	0.32994126
69	MAPK3	0.32608593
70	MAP4K2	0.31796869
71	MAPK8	0.29164256
72	FGFR3	0.28356583
73	TXK	0.27278186
74	GRK7	0.26010188
75	CAMKK1	0.24705527
76	INSR	0.24416806
77	MAPK10	0.23462694
78	PTK2B	0.22532504
79	CAMKK2	0.21489701
80	EPHA3	0.20394165
81	GRK5	0.19397519
82	PINK1	0.17392343
83	GSK3B	0.17291953
84	GSK3A	0.15744506
85	MAPK1	0.15014834
86	STK3	0.14109600
87	PRKCZ	0.13855347
88	BRSK1	0.12553174
89	TLK1	0.12260362
90	INSRR	0.11781246
91	CDK1	0.11348921
92	PRKCQ	0.10982658
93	PRKCD	0.10202783
94	AURKB	0.09415151
95	WNK3	0.08540491
96	LYN	0.08503417
97	PLK2	0.08208536
98	FYN	0.07793427
99	PDK1	0.07150399
100	CDK5	0.07049389

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	7.10840061
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.82646965
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.61195407
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.96071727
5	Proteasome_Homo sapiens_hsa03050	2.65279483
6	Sulfur metabolism_Homo sapiens_hsa00920	2.57508254
7	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.56087640
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.34919208
9	Basal transcription factors_Homo sapiens_hsa03022	2.27796517
10	Caffeine metabolism_Homo sapiens_hsa00232	2.19540152
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15945913
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12524090
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.09475998
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.95491705
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.88094241
16	p53 signaling pathway_Homo sapiens_hsa04115	1.51051835
17	Folate biosynthesis_Homo sapiens_hsa00790	1.46285001
18	Sulfur relay system_Homo sapiens_hsa04122	1.45768540
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.45280487
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.44578637
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40149373
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.38375870
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.36333801
24	Alzheimers disease_Homo sapiens_hsa05010	1.32917019
25	Phototransduction_Homo sapiens_hsa04744	1.32146257
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.27874461
27	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.23379305
28	Nicotine addiction_Homo sapiens_hsa05033	1.22911812
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19236014
30	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.15386374
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15134395
32	Parkinsons disease_Homo sapiens_hsa05012	1.11977360
33	Huntingtons disease_Homo sapiens_hsa05016	1.09185840
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.05581996
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.05477568
36	RNA degradation_Homo sapiens_hsa03018	1.03838561
37	Prion diseases_Homo sapiens_hsa05020	0.98707489
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.97857467
39	Homologous recombination_Homo sapiens_hsa03440	0.97503803
40	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.97114027
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.94251448
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90203442
43	Regulation of autophagy_Homo sapiens_hsa04140	0.85767454
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.85453880
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.84768379
46	Base excision repair_Homo sapiens_hsa03410	0.84028456
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.83934955
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83525324
49	DNA replication_Homo sapiens_hsa03030	0.81873772
50	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.73596258
51	Thyroid cancer_Homo sapiens_hsa05216	0.71788548
52	Morphine addiction_Homo sapiens_hsa05032	0.66525739
53	Purine metabolism_Homo sapiens_hsa00230	0.64959127
54	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61520916
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60826188
56	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.60155621
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59497012
58	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.57516492
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55523233
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.54548514
61	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54294956
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52974149
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51722631
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48990616
65	Galactose metabolism_Homo sapiens_hsa00052	0.47409712
66	GABAergic synapse_Homo sapiens_hsa04727	0.46427293
67	Retinol metabolism_Homo sapiens_hsa00830	0.46177156
68	RNA polymerase_Homo sapiens_hsa03020	0.45048767
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44647465
70	Taste transduction_Homo sapiens_hsa04742	0.44641809
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43998342
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43056312
73	Melanogenesis_Homo sapiens_hsa04916	0.42761189
74	Histidine metabolism_Homo sapiens_hsa00340	0.41395395
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.41039823
76	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.40711929
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40444669
78	Metabolic pathways_Homo sapiens_hsa01100	0.40363349
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39687186
80	Wnt signaling pathway_Homo sapiens_hsa04310	0.38451385
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35878859
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.35311655
83	Axon guidance_Homo sapiens_hsa04360	0.34597452
84	Insulin secretion_Homo sapiens_hsa04911	0.33887006
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33006609
86	Serotonergic synapse_Homo sapiens_hsa04726	0.32682826
87	Lysosome_Homo sapiens_hsa04142	0.30676690
88	ABC transporters_Homo sapiens_hsa02010	0.30204568
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.29222677
90	One carbon pool by folate_Homo sapiens_hsa00670	0.27406547
91	HTLV-I infection_Homo sapiens_hsa05166	0.26817449
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.25942023
93	FoxO signaling pathway_Homo sapiens_hsa04068	0.25397886
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24722762
95	Hepatitis B_Homo sapiens_hsa05161	0.24536845
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.23272872
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.22924882
98	Olfactory transduction_Homo sapiens_hsa04740	0.21513101
99	Peroxisome_Homo sapiens_hsa04146	0.19726134
100	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.19417728

HMGB3P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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