ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of female gonad development (GO:2000194)	8.76039366
2	tachykinin receptor signaling pathway (GO:0007217)	8.65909579
3	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	6.89211362
4	rRNA methylation (GO:0031167)	6.75497344
5	rRNA modification (GO:0000154)	6.23441637
6	positive regulation of digestive system process (GO:0060456)	5.72518729
7	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	5.70309405
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	5.70309405
9	regulation of translation, ncRNA-mediated (GO:0045974)	5.70309405
10	cranial nerve morphogenesis (GO:0021602)	5.65017749
11	nerve growth factor signaling pathway (GO:0038180)	5.33206202
12	response to misfolded protein (GO:0051788)	4.96205539
13	negative regulation of granulocyte differentiation (GO:0030853)	4.95986401
14	negative regulation of neurotransmitter secretion (GO:0046929)	4.91957900
15	monoubiquitinated protein deubiquitination (GO:0035520)	4.81296458
16	definitive hemopoiesis (GO:0060216)	4.71061897
17	regulation of sarcomere organization (GO:0060297)	4.51414950
18	pre-miRNA processing (GO:0031054)	4.39328194
19	positive regulation of vasculogenesis (GO:2001214)	4.27376162
20	regulation of establishment of cell polarity (GO:2000114)	4.21802670
21	negative regulation of translational initiation (GO:0045947)	4.01085689
22	NAD biosynthetic process (GO:0009435)	3.98099607
23	negative regulation of neurotransmitter transport (GO:0051589)	3.92188163
24	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	3.83199400
25	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	3.83199400
26	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.67616345
27	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.67616345
28	positive regulation of male gonad development (GO:2000020)	3.67284097
29	Rap protein signal transduction (GO:0032486)	3.62540587
30	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.58801300
31	response to histamine (GO:0034776)	3.54091944
32	cochlea development (GO:0090102)	3.51039102
33	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.47583046
34	relaxation of smooth muscle (GO:0044557)	3.45176484
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41385130
36	response to pheromone (GO:0019236)	3.34823603
37	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.34069823
38	organ growth (GO:0035265)	3.32493335
39	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.29224908
40	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.29224908
41	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.29081368
42	regulation of inositol phosphate biosynthetic process (GO:0010919)	3.28797410
43	motile cilium assembly (GO:0044458)	3.26337805
44	dentate gyrus development (GO:0021542)	3.21188487
45	cell differentiation involved in metanephros development (GO:0072202)	3.20011626
46	negative regulation of norepinephrine secretion (GO:0010700)	3.19895653
47	negative regulation of systemic arterial blood pressure (GO:0003085)	3.19521804
48	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.18060334
49	detection of light stimulus involved in visual perception (GO:0050908)	3.16802303
50	detection of light stimulus involved in sensory perception (GO:0050962)	3.16802303
51	regulation of male gonad development (GO:2000018)	3.16436021
52	negative regulation by host of viral transcription (GO:0043922)	3.13931417
53	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.05171989
54	mRNA cleavage (GO:0006379)	3.04436558
55	positive regulation of guanylate cyclase activity (GO:0031284)	3.00420296
56	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.97395870
57	endothelial cell chemotaxis (GO:0035767)	2.96971188
58	regulation of vasculogenesis (GO:2001212)	2.95456876
59	positive regulation of steroid hormone secretion (GO:2000833)	2.95167635
60	left/right pattern formation (GO:0060972)	2.93562174
61	positive regulation of mRNA catabolic process (GO:0061014)	2.91447402
62	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.88851197
63	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.88801088
64	hematopoietic stem cell proliferation (GO:0071425)	2.87933787
65	regulation of pigment cell differentiation (GO:0050932)	2.87606981
66	pyridine nucleotide biosynthetic process (GO:0019363)	2.85171570
67	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.85171570
68	positive regulation of granulocyte differentiation (GO:0030854)	2.84101358
69	adaptation of signaling pathway (GO:0023058)	2.82040082
70	purine deoxyribonucleotide catabolic process (GO:0009155)	2.81128593
71	epithelial cilium movement (GO:0003351)	2.77823266
72	regulation of digestive system process (GO:0044058)	2.75750728
73	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.72259187
74	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.70940570
75	adenosine receptor signaling pathway (GO:0001973)	2.70571144
76	base-excision repair, AP site formation (GO:0006285)	2.70459419
77	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.69664341
78	left/right axis specification (GO:0070986)	2.69425999
79	chemosensory behavior (GO:0007635)	2.69230176
80	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.67844528
81	positive regulation of mast cell degranulation (GO:0043306)	2.67844528
82	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.67613111
83	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.64967143
84	positive regulation of Rap GTPase activity (GO:0032854)	2.64849068
85	cartilage morphogenesis (GO:0060536)	2.63171465
86	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.62390351
87	response to nerve growth factor (GO:1990089)	2.62072647
88	cellular response to nerve growth factor stimulus (GO:1990090)	2.62072647
89	coenzyme catabolic process (GO:0009109)	2.62015705
90	regulation of guanylate cyclase activity (GO:0031282)	2.60455181
91	sperm motility (GO:0030317)	2.55301074
92	positive regulation of mRNA 3-end processing (GO:0031442)	2.54531580
93	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.52600779
94	centriole replication (GO:0007099)	2.50946297
95	negative regulation of metanephros development (GO:0072217)	2.50193859
96	postsynaptic membrane organization (GO:0001941)	2.49161100
97	auditory receptor cell stereocilium organization (GO:0060088)	2.48566067
98	regulation of Rap GTPase activity (GO:0032317)	2.47746165
99	positive regulation of mast cell activation (GO:0033005)	2.47251641
100	cilium or flagellum-dependent cell motility (GO:0001539)	2.47074709

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.74811462
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.71867065
3	SCL_19346495_ChIP-Seq_HPC-7_Human	2.66645564
4	DROSHA_22980978_ChIP-Seq_HELA_Human	2.66219977
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.62404061
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.49379185
7	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.23513487
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.20245467
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19717195
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16222126
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.15933145
12	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.11818322
13	BCAT_22108803_ChIP-Seq_LS180_Human	2.02871208
14	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	2.00733027
15	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.00564734
16	EZH2_22144423_ChIP-Seq_EOC_Human	10.6027757
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.98948261
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91001952
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.90445473
20	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90445473
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.86629670
22	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.85637988
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.82273806
24	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.81805191
25	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.76432418
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73819451
27	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.64005286
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.62801308
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.60576087
30	RXR_22108803_ChIP-Seq_LS180_Human	1.53083285
31	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.51952461
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.49952271
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.49952271
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47563505
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40560003
36	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35674238
37	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.32796744
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31869010
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.29174690
40	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27829219
41	VDR_24787735_ChIP-Seq_THP-1_Human	1.25985799
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.25939587
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21850120
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17009825
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16765504
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.16248533
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15332781
48	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.15167589
49	FUS_26573619_Chip-Seq_HEK293_Human	1.14274052
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14097104
51	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.13478050
52	ERA_21632823_ChIP-Seq_H3396_Human	1.13461681
53	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12136836
54	STAT3_23295773_ChIP-Seq_U87_Human	1.11047200
55	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.10273398
56	TCF4_23295773_ChIP-Seq_U87_Human	1.10126268
57	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.07738015
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07621115
59	P300_19829295_ChIP-Seq_ESCs_Human	1.07331236
60	GATA3_26560356_Chip-Seq_TH1_Human	1.06277978
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05974071
62	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04031850
63	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.02656548
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02242970
65	E2F1_20622854_ChIP-Seq_HELA_Human	1.01972300
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01641897
67	CBP_20019798_ChIP-Seq_JUKART_Human	0.99052201
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99052201
69	TCF4_22108803_ChIP-Seq_LS180_Human	0.98192323
70	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97491343
71	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96961536
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95853285
73	CTCF_27219007_Chip-Seq_Bcells_Human	0.94114582
74	EWS_26573619_Chip-Seq_HEK293_Human	0.93856868
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93459698
76	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.93229978
77	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.92876964
78	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.92321117
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91589144
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90622552
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.89857134
82	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.88055255
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.87817929
84	GBX2_23144817_ChIP-Seq_PC3_Human	0.87747400
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87565085
86	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.87303055
87	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.86781082
88	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.86458728
89	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.86444608
90	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.86172020
91	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.86079614
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85837541
93	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.85404195
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.84144454
95	OCT4_20526341_ChIP-Seq_ESCs_Human	0.83329855
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.82767685
97	NFYA_21822215_ChIP-Seq_K562_Human	0.82497483
98	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.82459928
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81209292
100	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.80896579

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001501_abnormal_sleep_pattern	3.98145229
2	MP0006276_abnormal_autonomic_nervous	3.82165514
3	MP0009697_abnormal_copulation	3.02098008
4	MP0003878_abnormal_ear_physiology	2.95887479
5	MP0005377_hearing/vestibular/ear_phenot	2.95887479
6	MP0000372_irregular_coat_pigmentation	2.93372040
7	MP0009379_abnormal_foot_pigmentation	2.89024462
8	MP0002249_abnormal_larynx_morphology	2.88359693
9	MP0005670_abnormal_white_adipose	2.67921074
10	MP0003195_calcinosis	2.65635814
11	MP0002735_abnormal_chemical_nociception	2.51274863
12	MP0005084_abnormal_gallbladder_morpholo	2.49089420
13	MP0006292_abnormal_olfactory_placode	2.40860662
14	MP0004133_heterotaxia	2.23715884
15	MP0001188_hyperpigmentation	2.19337923
16	MP0003646_muscle_fatigue	2.14575072
17	MP0003942_abnormal_urinary_system	2.06606048
18	MP0002396_abnormal_hematopoietic_system	2.04840083
19	MP0010386_abnormal_urinary_bladder	1.99256431
20	MP0001440_abnormal_grooming_behavior	1.97047794
21	MP0001348_abnormal_lacrimal_gland	1.77991037
22	MP0003943_abnormal_hepatobiliary_system	1.75534356
23	MP0004145_abnormal_muscle_electrophysio	1.73985659
24	MP0004142_abnormal_muscle_tone	1.70325748
25	MP0005645_abnormal_hypothalamus_physiol	1.68015513
26	MP0002733_abnormal_thermal_nociception	1.64037905
27	MP0005083_abnormal_biliary_tract	1.55433154
28	MP0001485_abnormal_pinna_reflex	1.52287919
29	MP0005551_abnormal_eye_electrophysiolog	1.51614697
30	MP0008789_abnormal_olfactory_epithelium	1.49411995
31	MP0001963_abnormal_hearing_physiology	1.49247935
32	MP0008872_abnormal_physiological_respon	1.47633178
33	MP0003763_abnormal_thymus_physiology	1.39567574
34	MP0001970_abnormal_pain_threshold	1.38956273
35	MP0001905_abnormal_dopamine_level	1.37447611
36	MP0000026_abnormal_inner_ear	1.35178713
37	MP0009250_abnormal_appendicular_skeleto	1.29168411
38	MP0003718_maternal_effect	1.27093741
39	MP0002928_abnormal_bile_duct	1.26132913
40	MP0001664_abnormal_digestion	1.23800985
41	MP0005464_abnormal_platelet_physiology	1.22016963
42	MP0003283_abnormal_digestive_organ	1.20804621
43	MP0005409_darkened_coat_color	1.17606657
44	MP0003698_abnormal_male_reproductive	1.17505349
45	MP0002557_abnormal_social/conspecific_i	1.17045581
46	MP0000678_abnormal_parathyroid_gland	1.15420948
47	MP0000470_abnormal_stomach_morphology	1.14266182
48	MP0004808_abnormal_hematopoietic_stem	1.13601258
49	MP0005410_abnormal_fertilization	1.11414064
50	MP0009840_abnormal_foam_cell	1.09443412
51	MP0002184_abnormal_innervation	1.09403847
52	MP0009745_abnormal_behavioral_response	1.08172940
53	MP0001119_abnormal_female_reproductive	1.07509063
54	MP0002876_abnormal_thyroid_physiology	1.05776300
55	MP0002734_abnormal_mechanical_nocicepti	1.05675184
56	MP0003635_abnormal_synaptic_transmissio	1.05415525
57	MP0005499_abnormal_olfactory_system	1.03983502
58	MP0005394_taste/olfaction_phenotype	1.03983502
59	MP0001346_abnormal_lacrimal_gland	1.00713649
60	MP0003880_abnormal_central_pattern	1.00287343
61	MP0000653_abnormal_sex_gland	1.00178273
62	MP0000049_abnormal_middle_ear	0.98247904
63	MP0001765_abnormal_ion_homeostasis	0.98088985
64	MP0001486_abnormal_startle_reflex	0.95725189
65	MP0002572_abnormal_emotion/affect_behav	0.94478108
66	MP0001929_abnormal_gametogenesis	0.91432780
67	MP0005646_abnormal_pituitary_gland	0.91331783
68	MP0000639_abnormal_adrenal_gland	0.90975701
69	MP0003279_aneurysm	0.90880023
70	MP0002653_abnormal_ependyma_morphology	0.90404466
71	MP0002210_abnormal_sex_determination	0.87330371
72	MP0000681_abnormal_thyroid_gland	0.86873447
73	MP0008995_early_reproductive_senescence	0.86698590
74	MP0002638_abnormal_pupillary_reflex	0.84711983
75	MP0001968_abnormal_touch/_nociception	0.84566486
76	MP0002067_abnormal_sensory_capabilities	0.83787402
77	MP0002752_abnormal_somatic_nervous	0.82971615
78	MP0000566_synostosis	0.82193455
79	MP0005085_abnormal_gallbladder_physiolo	0.80987282
80	MP0001873_stomach_inflammation	0.80758900
81	MP0003787_abnormal_imprinting	0.80381590
82	MP0002089_abnormal_postnatal_growth/wei	0.78862030
83	MP0000778_abnormal_nervous_system	0.78282404
84	MP0005647_abnormal_sex_gland	0.77060025
85	MP0003937_abnormal_limbs/digits/tail_de	0.76293312
86	MP0003385_abnormal_body_wall	0.76123194
87	MP0001529_abnormal_vocalization	0.75741309
88	MP0002161_abnormal_fertility/fecundity	0.75331276
89	MP0002234_abnormal_pharynx_morphology	0.74124745
90	MP0009278_abnormal_bone_marrow	0.74074178
91	MP0000462_abnormal_digestive_system	0.69531315
92	MP0005395_other_phenotype	0.65397638
93	MP0000534_abnormal_ureter_morphology	0.64244446
94	MP0005195_abnormal_posterior_eye	0.63966190
95	MP0001286_abnormal_eye_development	0.63599274
96	MP0003119_abnormal_digestive_system	0.63482379
97	MP0005174_abnormal_tail_pigmentation	0.62606366
98	MP0001145_abnormal_male_reproductive	0.61913287
99	MP0000955_abnormal_spinal_cord	0.61690038
100	MP0005253_abnormal_eye_physiology	0.61502612

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	7.13706808
2	Decreased central vision (HP:0007663)	4.99668797
3	Hypoplasia of the iris (HP:0007676)	4.70706049
4	Abnormality of macular pigmentation (HP:0008002)	4.54194880
5	Retinal dysplasia (HP:0007973)	3.94344966
6	Progressive cerebellar ataxia (HP:0002073)	3.84553618
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.79250066
8	Proximal tubulopathy (HP:0000114)	3.64506128
9	Abnormality of the diencephalon (HP:0010662)	3.50977221
10	Facial hemangioma (HP:0000329)	3.32548145
11	Congenital stationary night blindness (HP:0007642)	3.22927952
12	Lip pit (HP:0100267)	3.18630037
13	Abnormality of binocular vision (HP:0011514)	3.13827382
14	Diplopia (HP:0000651)	3.13827382
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.05066540
16	Abdominal situs inversus (HP:0003363)	3.04889567
17	Abnormality of abdominal situs (HP:0011620)	3.04889567
18	Narrow nasal bridge (HP:0000446)	2.96658155
19	Abnormality of lateral ventricle (HP:0030047)	2.93443016
20	Capillary hemangiomas (HP:0005306)	2.90821982
21	Hypophosphatemic rickets (HP:0004912)	2.90417256
22	Attenuation of retinal blood vessels (HP:0007843)	2.82443310
23	Pancreatic cysts (HP:0001737)	2.79606298
24	Poikiloderma (HP:0001029)	2.76382673
25	Oligodontia (HP:0000677)	2.75006196
26	Macular degeneration (HP:0000608)	2.68720018
27	Areflexia of lower limbs (HP:0002522)	2.64739536
28	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.64713864
29	Chronic hepatic failure (HP:0100626)	2.61673100
30	Sclerocornea (HP:0000647)	2.53298476
31	Abnormality of the columella (HP:0009929)	2.52873198
32	Abnormality of midbrain morphology (HP:0002418)	2.50903172
33	Molar tooth sign on MRI (HP:0002419)	2.50903172
34	Intellectual disability, progressive (HP:0006887)	2.47197589
35	Aplasia/Hypoplasia of the lens (HP:0008063)	2.44632835
36	Abnormality of the anterior chamber (HP:0000593)	2.40445875
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36708190
38	Absent/shortened dynein arms (HP:0200106)	2.36708190
39	Pancreatic fibrosis (HP:0100732)	2.36130198
40	Dysautonomia (HP:0002459)	2.34628392
41	Coarctation of aorta (HP:0001680)	2.33447103
42	Gaze-evoked nystagmus (HP:0000640)	2.32661572
43	Urethral obstruction (HP:0000796)	2.31900005
44	Dysmetric saccades (HP:0000641)	2.29998834
45	Renal Fanconi syndrome (HP:0001994)	2.23116928
46	Facial shape deformation (HP:0011334)	2.22603727
47	Potter facies (HP:0002009)	2.22603727
48	Episodic fever (HP:0001954)	2.21791395
49	Self-mutilation (HP:0000742)	2.20244644
50	Abnormality of DNA repair (HP:0003254)	2.16816919
51	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.16427978
52	Abnormal ciliary motility (HP:0012262)	2.16401167
53	Increased hepatocellular lipid droplets (HP:0006565)	2.15003253
54	Cystic liver disease (HP:0006706)	2.14382945
55	Hypoplastic ischia (HP:0003175)	2.11962537
56	Acute lymphatic leukemia (HP:0006721)	2.10026387
57	Hyperglycinuria (HP:0003108)	2.06510420
58	Asplenia (HP:0001746)	2.05433969
59	Protruding tongue (HP:0010808)	2.05179317
60	Postural instability (HP:0002172)	2.04770091
61	Ureteral stenosis (HP:0000071)	2.04627855
62	Urinary bladder sphincter dysfunction (HP:0002839)	2.04399695
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04226504
64	High anterior hairline (HP:0009890)	2.04000486
65	Median cleft lip (HP:0000161)	2.03455553
66	Venous insufficiency (HP:0005293)	2.03047194
67	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01960601
68	Hemorrhage of the eye (HP:0011885)	2.00040152
69	True hermaphroditism (HP:0010459)	1.99694540
70	Ectopia lentis (HP:0001083)	1.99496016
71	Hyperglycinemia (HP:0002154)	1.96864135
72	Supernumerary bones of the axial skeleton (HP:0009144)	1.96507069
73	Autoimmune thrombocytopenia (HP:0001973)	1.95752990
74	Abnormality of the vitreous humor (HP:0004327)	1.94477241
75	Ureteral obstruction (HP:0006000)	1.93811141
76	External ophthalmoplegia (HP:0000544)	1.93628452
77	Lipid accumulation in hepatocytes (HP:0006561)	1.93400620
78	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92830750
79	Abnormal respiratory epithelium morphology (HP:0012253)	1.92830750
80	Dyschromatopsia (HP:0007641)	1.92777498
81	Gonadotropin excess (HP:0000837)	1.92410708
82	Pendular nystagmus (HP:0012043)	1.89898002
83	Abnormality of the pubic bones (HP:0003172)	1.89697938
84	Abnormality of cochlea (HP:0000375)	1.89203754
85	Abnormality of T cell physiology (HP:0011840)	1.89198929
86	Acute myeloid leukemia (HP:0004808)	1.86087902
87	Ectopic kidney (HP:0000086)	1.85969848
88	Recurrent pneumonia (HP:0006532)	1.85745425
89	Respiratory difficulties (HP:0002880)	1.82179662
90	Abnormality of the lower motor neuron (HP:0002366)	1.82085606
91	Nephronophthisis (HP:0000090)	1.80793317
92	Retinal detachment (HP:0000541)	1.79409909
93	Hypoplasia of the pons (HP:0012110)	1.74810102
94	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73892566
95	Congenital hepatic fibrosis (HP:0002612)	1.72733739
96	Facial cleft (HP:0002006)	1.72713922
97	Abnormality of the pupil (HP:0000615)	1.69970999
98	Ketosis (HP:0001946)	1.69016312
99	Reduced antithrombin III activity (HP:0001976)	1.68286728
100	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.64834783

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.14124257
2	NUAK1	3.97672504
3	FRK	3.79556264
4	ERN1	3.63412503
5	BCKDK	2.99741952
6	ICK	2.79208188
7	PLK4	2.76439357
8	NEK2	2.74191720
9	PINK1	2.61147398
10	CDC7	2.19138048
11	TNK2	2.17769245
12	TNIK	1.97385396
13	MATK	1.93963547
14	MST1R	1.93238328
15	VRK2	1.72831645
16	PASK	1.68871739
17	WNK4	1.67717524
18	SIK2	1.63520346
19	BMPR1B	1.61863778
20	MAP2K7	1.54259770
21	EIF2AK3	1.49366558
22	INSRR	1.48551947
23	NEK6	1.38401398
24	CDK12	1.37843076
25	STK38L	1.23720641
26	WNK1	1.22582540
27	KIT	1.14653700
28	TGFBR1	1.12499089
29	ADRBK2	1.10817488
30	STK39	1.09622248
31	PBK	1.04991001
32	MAP3K4	0.97622207
33	HIPK2	0.95797332
34	TEC	0.94419732
35	BTK	0.93173324
36	PRKCE	0.92491437
37	STK3	0.89959828
38	DDR2	0.88381457
39	MKNK2	0.87886192
40	FES	0.84918146
41	OXSR1	0.83541011
42	MAP3K7	0.82626950
43	WNK3	0.80736061
44	RPS6KA6	0.80316546
45	NME1	0.79072043
46	NTRK1	0.78331164
47	CSNK1G1	0.74095865
48	MARK3	0.73704667
49	MAP3K9	0.73114649
50	VRK1	0.72823925
51	TIE1	0.70252122
52	CDK4	0.69802221
53	MKNK1	0.69367327
54	CAMK1G	0.69271337
55	MUSK	0.68904888
56	ADRBK1	0.68287630
57	PRKG2	0.67889757
58	PIK3CG	0.67646770
59	ACVR1B	0.66906407
60	NLK	0.66867552
61	CDK7	0.66409913
62	RPS6KC1	0.65603854
63	RPS6KL1	0.65603854
64	CDK9	0.63894546
65	CDK6	0.63621744
66	PDK2	0.63480231
67	MAPK15	0.60864180
68	SRPK1	0.60314342
69	NTRK3	0.56946885
70	OBSCN	0.56217769
71	MAP3K6	0.56099335
72	EPHA4	0.55750084
73	PRKCQ	0.54550638
74	MELK	0.53253123
75	EIF2AK2	0.50038809
76	CSNK1A1	0.49230816
77	PNCK	0.46880057
78	CSNK1G3	0.46099430
79	PRKCG	0.43931357
80	CSNK1A1L	0.43604103
81	PRKG1	0.43292890
82	LRRK2	0.42135652
83	STK11	0.41873507
84	CAMK1	0.40687882
85	CSNK1G2	0.39251387
86	SYK	0.38720667
87	GRK6	0.38705601
88	MAP2K6	0.38328289
89	PRKCA	0.36857317
90	GRK1	0.36417589
91	DMPK	0.36357904
92	SIK3	0.34167824
93	MARK2	0.33741865
94	TAOK3	0.32288875
95	ATR	0.31499060
96	MAP3K1	0.30940085
97	MAP3K10	0.30825510
98	MAPKAPK2	0.30047682
99	PRKAA2	0.29952139
100	ARAF	0.29535112

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.65206193
2	Taste transduction_Homo sapiens_hsa04742	3.07620392
3	Morphine addiction_Homo sapiens_hsa05032	2.40649232
4	Olfactory transduction_Homo sapiens_hsa04740	2.19684548
5	Butanoate metabolism_Homo sapiens_hsa00650	2.18798591
6	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.17481323
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.16451766
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.12945779
9	GABAergic synapse_Homo sapiens_hsa04727	2.07140009
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.05278724
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91676974
12	Platelet activation_Homo sapiens_hsa04611	1.89089317
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84937443
14	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.83197359
15	Salivary secretion_Homo sapiens_hsa04970	1.83193469
16	Serotonergic synapse_Homo sapiens_hsa04726	1.79258705
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.79102699
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.75437738
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.75345755
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.70999212
21	Asthma_Homo sapiens_hsa05310	1.67948958
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.61144652
23	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.60729195
24	Phototransduction_Homo sapiens_hsa04744	1.59032750
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.56204112
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.55120962
27	Circadian entrainment_Homo sapiens_hsa04713	1.55009118
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54913171
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.49236684
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.45824613
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39735252
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.36769756
33	Retinol metabolism_Homo sapiens_hsa00830	1.35207383
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33849331
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22339795
36	ABC transporters_Homo sapiens_hsa02010	1.20112769
37	Renin secretion_Homo sapiens_hsa04924	1.18680535
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.18037563
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17991353
40	Gastric acid secretion_Homo sapiens_hsa04971	1.13511652
41	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.12406569
42	Cholinergic synapse_Homo sapiens_hsa04725	1.10746473
43	Propanoate metabolism_Homo sapiens_hsa00640	1.09002039
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.08691912
45	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.08419123
46	Primary immunodeficiency_Homo sapiens_hsa05340	1.06510181
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.05179762
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.01207974
49	Pancreatic secretion_Homo sapiens_hsa04972	0.99422569
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98252748
51	Sulfur relay system_Homo sapiens_hsa04122	0.98159392
52	Base excision repair_Homo sapiens_hsa03410	0.96929419
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.93383052
54	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.92011215
55	Glutathione metabolism_Homo sapiens_hsa00480	0.89692210
56	Lysine degradation_Homo sapiens_hsa00310	0.88403772
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.84042457
58	Cocaine addiction_Homo sapiens_hsa05030	0.81319749
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.80087796
60	Insulin secretion_Homo sapiens_hsa04911	0.80005131
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.79852987
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.74281517
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.73347057
64	Peroxisome_Homo sapiens_hsa04146	0.72926340
65	Long-term potentiation_Homo sapiens_hsa04720	0.71877919
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.70598005
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69681656
68	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.65168511
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.64281048
70	Caffeine metabolism_Homo sapiens_hsa00232	0.59873199
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58763923
72	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.57623129
73	Ras signaling pathway_Homo sapiens_hsa04014	0.57481734
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57469944
75	One carbon pool by folate_Homo sapiens_hsa00670	0.56233403
76	Basal transcription factors_Homo sapiens_hsa03022	0.54111867
77	Wnt signaling pathway_Homo sapiens_hsa04310	0.53195419
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.52840137
79	Homologous recombination_Homo sapiens_hsa03440	0.52125299
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51075213
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48995233
82	Fanconi anemia pathway_Homo sapiens_hsa03460	0.47774948
83	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.46716038
84	RNA degradation_Homo sapiens_hsa03018	0.45182790
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.44787232
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44608969
87	Fatty acid degradation_Homo sapiens_hsa00071	0.43773155
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.41203860
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.40904686
90	Purine metabolism_Homo sapiens_hsa00230	0.40695685
91	Regulation of autophagy_Homo sapiens_hsa04140	0.40396816
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38761249
93	Graft-versus-host disease_Homo sapiens_hsa05332	0.38260585
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38230577
95	RNA polymerase_Homo sapiens_hsa03020	0.37413190
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35755497
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.34258532
98	Amphetamine addiction_Homo sapiens_hsa05031	0.34212145
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34192199
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.32395896

HMGB3P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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