HMGB3P22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.86574600
2cell wall macromolecule catabolic process (GO:0016998)7.23244996
3microtubule depolymerization (GO:0007019)6.33614201
4maturation of SSU-rRNA (GO:0030490)6.26896880
5cell wall macromolecule metabolic process (GO:0044036)5.98737493
6seminiferous tubule development (GO:0072520)5.95353380
7spermatid nucleus differentiation (GO:0007289)5.41453703
8microtubule polymerization or depolymerization (GO:0031109)5.33349809
9viral transcription (GO:0019083)4.86891937
10translational termination (GO:0006415)4.82280317
11single strand break repair (GO:0000012)4.71428460
12centriole replication (GO:0007099)4.57116479
13intraciliary transport (GO:0042073)4.46731882
14ribosomal small subunit biogenesis (GO:0042274)4.46090414
15acrosome reaction (GO:0007340)4.41218572
16ribosomal small subunit assembly (GO:0000028)4.39592991
17nucleotide-excision repair, DNA gap filling (GO:0006297)4.19665468
18base-excision repair, AP site formation (GO:0006285)4.07024945
19sperm motility (GO:0030317)4.05224265
20cellular protein complex disassembly (GO:0043624)4.01477065
21centriole assembly (GO:0098534)3.92027554
22translational elongation (GO:0006414)3.91613794
23purine deoxyribonucleotide catabolic process (GO:0009155)3.90505148
24rRNA methylation (GO:0031167)3.89200411
25chromosome condensation (GO:0030261)3.87335373
26purine deoxyribonucleotide metabolic process (GO:0009151)3.86757443
27telomere maintenance via semi-conservative replication (GO:0032201)3.83405786
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80413479
29microtubule severing (GO:0051013)3.78931980
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76709764
31protein complex disassembly (GO:0043241)3.73763085
32cotranslational protein targeting to membrane (GO:0006613)3.72991171
33rRNA modification (GO:0000154)3.72569790
34glucosamine-containing compound catabolic process (GO:1901072)3.71227266
35axonal fasciculation (GO:0007413)3.68154170
36protein targeting to ER (GO:0045047)3.67810195
37purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.65453804
38cell differentiation involved in metanephros development (GO:0072202)3.55876859
39response to acidic pH (GO:0010447)3.53253407
40acrosome assembly (GO:0001675)3.53181548
41macromolecular complex disassembly (GO:0032984)3.52899178
42protein localization to endoplasmic reticulum (GO:0070972)3.50927296
43viral life cycle (GO:0019058)3.49226826
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48323446
45DNA packaging (GO:0006323)3.43329130
46regulation of centriole replication (GO:0046599)3.38527976
47L-serine metabolic process (GO:0006563)3.38457738
48fusion of sperm to egg plasma membrane (GO:0007342)3.37580835
49resolution of meiotic recombination intermediates (GO:0000712)3.35012831
50cellular ketone body metabolic process (GO:0046950)3.34926962
51regulation of penile erection (GO:0060405)3.32469163
52ribosomal large subunit biogenesis (GO:0042273)3.31336614
53deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.30739846
54multicellular organism reproduction (GO:0032504)3.26675241
55histone H3-K9 methylation (GO:0051567)3.25638816
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24841127
57regulation of mesenchymal cell apoptotic process (GO:2001053)3.24039831
58negative regulation of circadian rhythm (GO:0042754)3.22844373
59replication fork processing (GO:0031297)3.21881971
60spermatid development (GO:0007286)3.21074534
61tachykinin receptor signaling pathway (GO:0007217)3.21055950
62protein polyglutamylation (GO:0018095)3.20082475
63axon extension involved in axon guidance (GO:0048846)3.17866695
64neuron projection extension involved in neuron projection guidance (GO:1902284)3.17866695
65chromatin remodeling at centromere (GO:0031055)3.16023103
66protein localization to cilium (GO:0061512)3.15828799
672-deoxyribonucleotide metabolic process (GO:0009394)3.14010187
68retinal ganglion cell axon guidance (GO:0031290)3.07840288
69mitotic recombination (GO:0006312)3.01930521
70DNA strand elongation involved in DNA replication (GO:0006271)3.01857509
71histone H3-K9 modification (GO:0061647)3.01736529
72translesion synthesis (GO:0019985)2.99386956
73translational initiation (GO:0006413)2.98824412
74telomere maintenance via recombination (GO:0000722)2.95905970
75DNA integration (GO:0015074)2.93706472
76regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.93648561
77histone H2B ubiquitination (GO:0033523)2.91071715
78deoxyribonucleotide metabolic process (GO:0009262)2.90425306
79ketone body metabolic process (GO:1902224)2.86375489
80postsynaptic membrane organization (GO:0001941)2.86317272
81negative regulation of meiosis (GO:0045835)2.84042642
82deoxyribose phosphate metabolic process (GO:0019692)2.84006190
83sperm capacitation (GO:0048240)2.82863114
84cellular response to interferon-beta (GO:0035458)2.82492694
85telomere maintenance via telomere lengthening (GO:0010833)2.81139669
86urogenital system development (GO:0001655)2.80740116
87neuronal ion channel clustering (GO:0045161)2.80668246
88DNA strand elongation (GO:0022616)2.80597686
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.78532435
90neuron recognition (GO:0008038)2.77400191
91CENP-A containing nucleosome assembly (GO:0034080)2.75246148
92DNA-dependent DNA replication (GO:0006261)2.74302732
93negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73887041
94response to morphine (GO:0043278)2.73038306
95single fertilization (GO:0007338)2.72438822
96tRNA methylation (GO:0030488)2.72155249
97sperm-egg recognition (GO:0035036)2.70739403
98deoxyribonucleotide catabolic process (GO:0009264)2.70071564
99histone exchange (GO:0043486)2.69759084
100exocrine pancreas development (GO:0031017)2.66732001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.93760777
2E2F7_22180533_ChIP-Seq_HELA_Human5.28030640
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.49896574
4AR_21572438_ChIP-Seq_LNCaP_Human3.14710083
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00023077
6IRF1_19129219_ChIP-ChIP_H3396_Human2.77383636
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76425123
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.58933404
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.35269383
10VDR_22108803_ChIP-Seq_LS180_Human2.20126904
11FUS_26573619_Chip-Seq_HEK293_Human2.19459803
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.14064403
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04707166
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.98651994
15E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97757050
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87575052
17YY1_21170310_ChIP-Seq_MESCs_Mouse1.85114545
18IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76446473
19ZNF274_21170338_ChIP-Seq_K562_Hela1.74960272
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.69946362
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61786333
22ERG_20517297_ChIP-Seq_VCAP_Human1.56170300
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51038928
24RNF2_27304074_Chip-Seq_NSC_Mouse1.49757254
25CIITA_25753668_ChIP-Seq_RAJI_Human1.47828955
26EWS_26573619_Chip-Seq_HEK293_Human1.46049059
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45415011
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.45037463
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42546223
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42546223
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42544565
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42026523
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40972973
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.38378573
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.36671343
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33970624
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33622924
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28078447
39CBP_20019798_ChIP-Seq_JUKART_Human1.21044568
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21044568
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20656246
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20497153
43ER_23166858_ChIP-Seq_MCF-7_Human1.19823515
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.16575812
45CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16363439
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14764044
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10574061
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.09764545
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.09579864
50TAF2_19829295_ChIP-Seq_ESCs_Human1.08284445
51VDR_23849224_ChIP-Seq_CD4+_Human1.07776051
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05978706
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05617284
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.05231058
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05002045
56TAF15_26573619_Chip-Seq_HEK293_Human1.04489754
57TP53_22573176_ChIP-Seq_HFKS_Human1.03280567
58IGF1R_20145208_ChIP-Seq_DFB_Human1.02802037
59NFYB_21822215_ChIP-Seq_K562_Human1.02736141
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02116122
61NANOG_19829295_ChIP-Seq_ESCs_Human1.01168567
62SOX2_19829295_ChIP-Seq_ESCs_Human1.01168567
63ETV1_20927104_ChIP-Seq_GIST48_Human1.00194582
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99849927
65PHF8_20622853_ChIP-Seq_HELA_Human0.97668011
66CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97598352
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97539014
68CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97252298
69ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96606901
70MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96256170
71WDR5_24793694_ChIP-Seq_LNCAP_Human0.96129518
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95670120
73P300_19829295_ChIP-Seq_ESCs_Human0.95626809
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94801023
75MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.93695030
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93163772
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91854403
78REST_21632747_ChIP-Seq_MESCs_Mouse0.91648086
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90264334
80NCOR_22424771_ChIP-Seq_293T_Human0.89770658
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89113714
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89065406
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88511017
84NFYA_21822215_ChIP-Seq_K562_Human0.86308883
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.86006402
86RBPJ_21746931_ChIP-Seq_IB4_Human0.85308243
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.84114951
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83707178
89CTCF_27219007_Chip-Seq_Bcells_Human0.83376231
90ELF5_23300383_ChIP-Seq_T47D_Human0.83316849
91BCOR_27268052_Chip-Seq_Bcells_Human0.82826034
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.81993775
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.81477225
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81070708
95E2F1_20622854_ChIP-Seq_HELA_Human0.80526123
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.80515471
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80277015
98JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80235105
99NANOG_20526341_ChIP-Seq_ESCs_Human0.79602443
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.79514210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.09743244
2MP0001346_abnormal_lacrimal_gland3.93211817
3MP0009379_abnormal_foot_pigmentation3.69561586
4MP0002163_abnormal_gland_morphology3.42562160
5MP0003787_abnormal_imprinting3.37421415
6MP0000372_irregular_coat_pigmentation3.15601184
7MP0005410_abnormal_fertilization2.88606332
8MP0010030_abnormal_orbit_morphology2.73630805
9MP0002638_abnormal_pupillary_reflex2.68544925
10MP0005379_endocrine/exocrine_gland_phen2.42157872
11MP0001485_abnormal_pinna_reflex2.36310742
12MP0003880_abnormal_central_pattern2.35438510
13MP0001986_abnormal_taste_sensitivity2.20814793
14MP0001529_abnormal_vocalization2.15172220
15MP0004145_abnormal_muscle_electrophysio2.14188484
16MP0002735_abnormal_chemical_nociception2.02284221
17MP0008995_early_reproductive_senescence2.01507474
18MP0005377_hearing/vestibular/ear_phenot1.97784475
19MP0003878_abnormal_ear_physiology1.97784475
20MP0005310_abnormal_salivary_gland1.94877996
21MP0003123_paternal_imprinting1.92336589
22MP0008789_abnormal_olfactory_epithelium1.79326776
23MP0002282_abnormal_trachea_morphology1.69578411
24MP0003121_genomic_imprinting1.68382646
25MP0010094_abnormal_chromosome_stability1.66692229
26MP0005645_abnormal_hypothalamus_physiol1.63853841
27MP0004742_abnormal_vestibular_system1.63348783
28MP0008058_abnormal_DNA_repair1.62987474
29MP0002160_abnormal_reproductive_system1.58355645
30MP0000778_abnormal_nervous_system1.57456169
31MP0003698_abnormal_male_reproductive1.56797194
32MP0002734_abnormal_mechanical_nocicepti1.54203159
33MP0006276_abnormal_autonomic_nervous1.53318726
34MP0002876_abnormal_thyroid_physiology1.50156786
35MP0005394_taste/olfaction_phenotype1.46666862
36MP0005499_abnormal_olfactory_system1.46666862
37MP0001929_abnormal_gametogenesis1.45204267
38MP0002396_abnormal_hematopoietic_system1.38840313
39MP0009697_abnormal_copulation1.37714777
40MP0002210_abnormal_sex_determination1.33060691
41MP0000955_abnormal_spinal_cord1.31288095
42MP0000681_abnormal_thyroid_gland1.30912305
43MP0009250_abnormal_appendicular_skeleto1.29056344
44MP0005551_abnormal_eye_electrophysiolog1.28394800
45MP0005423_abnormal_somatic_nervous1.28063529
46MP0008877_abnormal_DNA_methylation1.26417015
47MP0003315_abnormal_perineum_morphology1.24821206
48MP0001502_abnormal_circadian_rhythm1.17194446
49MP0002653_abnormal_ependyma_morphology1.14754515
50MP0000537_abnormal_urethra_morphology1.14703406
51MP0002557_abnormal_social/conspecific_i1.11872337
52MP0004142_abnormal_muscle_tone1.11548442
53MP0005187_abnormal_penis_morphology1.10488944
54MP0003136_yellow_coat_color1.08662435
55MP0001853_heart_inflammation1.08565079
56MP0005253_abnormal_eye_physiology1.08082427
57MP0006072_abnormal_retinal_apoptosis1.07612380
58MP0005084_abnormal_gallbladder_morpholo1.04479027
59MP0001984_abnormal_olfaction1.04139068
60MP0003186_abnormal_redox_activity1.02798211
61MP0008961_abnormal_basal_metabolism1.01679163
62MP0008875_abnormal_xenobiotic_pharmacok1.00928575
63MP0002184_abnormal_innervation0.98562277
64MP0005367_renal/urinary_system_phenotyp0.98338066
65MP0000516_abnormal_urinary_system0.98338066
66MP0001486_abnormal_startle_reflex0.97202389
67MP0004270_analgesia0.93135882
68MP0001145_abnormal_male_reproductive0.90725320
69MP0000653_abnormal_sex_gland0.87716940
70MP0000049_abnormal_middle_ear0.86588153
71MP0003950_abnormal_plasma_membrane0.85590819
72MP0000751_myopathy0.85292119
73MP0006036_abnormal_mitochondrial_physio0.85123552
74MP0000465_gastrointestinal_hemorrhage0.81600122
75MP0003635_abnormal_synaptic_transmissio0.81392190
76MP0001970_abnormal_pain_threshold0.80890926
77MP0008057_abnormal_DNA_replication0.79724900
78MP0001963_abnormal_hearing_physiology0.79534986
79MP0008569_lethality_at_weaning0.78825911
80MP0000026_abnormal_inner_ear0.78345853
81MP0002067_abnormal_sensory_capabilities0.77838218
82MP0003077_abnormal_cell_cycle0.77433846
83MP0002752_abnormal_somatic_nervous0.75502088
84MP0006035_abnormal_mitochondrial_morpho0.75163921
85MP0002882_abnormal_neuron_morphology0.74786021
86MP0003786_premature_aging0.74777947
87MP0003861_abnormal_nervous_system0.74658398
88MP0002249_abnormal_larynx_morphology0.74303612
89MP0002928_abnormal_bile_duct0.74170907
90MP0002161_abnormal_fertility/fecundity0.73343077
91MP0002272_abnormal_nervous_system0.71772293
92MP0001905_abnormal_dopamine_level0.69778006
93MP0004885_abnormal_endolymph0.69772570
94MP0008872_abnormal_physiological_respon0.68277379
95MP0002736_abnormal_nociception_after0.67755517
96MP0002572_abnormal_emotion/affect_behav0.67389055
97MP0001501_abnormal_sleep_pattern0.67312814
98MP0005670_abnormal_white_adipose0.66881282
99MP0001727_abnormal_embryo_implantation0.63669102
100MP0005266_abnormal_metabolism0.62243815

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.14193117
2Bell-shaped thorax (HP:0001591)5.26885853
3Type 2 muscle fiber atrophy (HP:0003554)5.24929425
4Muscle fiber atrophy (HP:0100295)4.55992100
5Abnormality of cells of the erythroid lineage (HP:0012130)4.22258923
6Septo-optic dysplasia (HP:0100842)4.20377885
7Nonprogressive disorder (HP:0003680)4.17684359
8Abnormal number of erythroid precursors (HP:0012131)3.66170795
9Hypoplastic ischia (HP:0003175)3.56807901
10Weak cry (HP:0001612)3.32983598
11Abnormality of the neuromuscular junction (HP:0003398)3.28365498
12Fatigable weakness (HP:0003473)3.28365498
13Macrocytic anemia (HP:0001972)3.27603078
14B lymphocytopenia (HP:0010976)3.27280674
15Nephronophthisis (HP:0000090)3.18324566
16Abnormality of B cell number (HP:0010975)3.16521755
17Absent septum pellucidum (HP:0001331)3.14094618
18Calcaneovalgus deformity (HP:0001848)3.09166502
19Severe combined immunodeficiency (HP:0004430)3.05164804
20Abnormality of the ischium (HP:0003174)2.94330283
21Abnormality of the labia minora (HP:0012880)2.78868569
22Long clavicles (HP:0000890)2.77930697
23Autoimmune hemolytic anemia (HP:0001890)2.74910285
24Severe visual impairment (HP:0001141)2.74291697
25Chronic hepatic failure (HP:0100626)2.72645934
26Abnormality of the septum pellucidum (HP:0007375)2.70953562
27Abnormality of midbrain morphology (HP:0002418)2.60850270
28Molar tooth sign on MRI (HP:0002419)2.60850270
29Deformed tarsal bones (HP:0008119)2.56461121
30Abnormality of DNA repair (HP:0003254)2.55939641
31Abnormality of the parietal bone (HP:0002696)2.55590726
32Metaphyseal dysplasia (HP:0100255)2.54244473
33Hyperglycinemia (HP:0002154)2.50921756
34Myokymia (HP:0002411)2.50286824
35Partial duplication of thumb phalanx (HP:0009944)2.49340341
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.48977241
37Absent epiphyses (HP:0010577)2.48977241
38Decreased muscle mass (HP:0003199)2.48943918
39Impulsivity (HP:0100710)2.48459533
40Tubulointerstitial nephritis (HP:0001970)2.42370241
41Easy fatigability (HP:0003388)2.37372227
42Acute lymphatic leukemia (HP:0006721)2.31451621
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30663328
44Chromsome breakage (HP:0040012)2.25546704
45Combined immunodeficiency (HP:0005387)2.24722931
46Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22263221
47Hypoplasia of the thymus (HP:0000778)2.22128549
48Anencephaly (HP:0002323)2.21552049
49Morphological abnormality of the inner ear (HP:0011390)2.21210123
50Agammaglobulinemia (HP:0004432)2.18469379
51Medial flaring of the eyebrow (HP:0010747)2.18360527
52Aplasia/Hypoplasia of the thymus (HP:0010515)2.15864890
53Abnormality of the renal medulla (HP:0100957)2.15137490
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13245661
55Optic nerve hypoplasia (HP:0000609)2.12137138
56Abnormality of macular pigmentation (HP:0008002)2.08998376
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08894697
58Abnormal tarsal ossification (HP:0008369)2.05866463
59Depressed nasal ridge (HP:0000457)2.04841900
60Partial duplication of the phalanx of hand (HP:0009999)2.04693363
61Mesangial abnormality (HP:0001966)2.03945373
62Colon cancer (HP:0003003)2.03188349
63Increased IgM level (HP:0003496)2.03123746
64Patent foramen ovale (HP:0001655)2.02378708
65Stenosis of the external auditory canal (HP:0000402)2.02310061
66Pallor (HP:0000980)2.01958475
67Thrombocytosis (HP:0001894)2.00809221
68Hypogonadotrophic hypogonadism (HP:0000044)2.00216027
69Hyperthyroidism (HP:0000836)1.97736596
70Poor suck (HP:0002033)1.95893249
71Popliteal pterygium (HP:0009756)1.94633830
72Unilateral renal agenesis (HP:0000122)1.92841172
73Autoimmune thrombocytopenia (HP:0001973)1.88912546
74Intellectual disability, moderate (HP:0002342)1.87444505
75Bony spicule pigmentary retinopathy (HP:0007737)1.85059161
76Neoplasm of the adrenal cortex (HP:0100641)1.83676123
77Rocker bottom foot (HP:0001838)1.82470701
78Abnormality of cochlea (HP:0000375)1.82203699
79Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81262322
80Retinal dysplasia (HP:0007973)1.80112145
81Thyroiditis (HP:0100646)1.79582571
82Stage 5 chronic kidney disease (HP:0003774)1.76983704
83Abnormality of reticulocytes (HP:0004312)1.75866805
84Abnormality of the pubic bones (HP:0003172)1.75003319
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74012223
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73419143
87Abnormality of alanine metabolism (HP:0010916)1.73419143
88Hyperalaninemia (HP:0003348)1.73419143
89Absent phalangeal crease (HP:0006109)1.70589394
90Abnormality of chromosome stability (HP:0003220)1.70333095
91Cupped ribs (HP:0000887)1.69686430
92IgM deficiency (HP:0002850)1.68774048
93Elevated erythrocyte sedimentation rate (HP:0003565)1.68759457
94Stomach cancer (HP:0012126)1.67130061
95Hepatic necrosis (HP:0002605)1.65947061
96Concave nail (HP:0001598)1.65121064
97Hyperglycinuria (HP:0003108)1.64731700
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.64593617
99Prolonged neonatal jaundice (HP:0006579)1.63795737
100Respiratory distress (HP:0002098)1.62357622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK8.29184188
2TRIM283.85504191
3PLK43.34586054
4PNCK2.74556545
5CDC72.71602608
6MARK32.60002244
7BMPR1B2.56038000
8CDK82.09365276
9SIK21.89364055
10BRD41.88378650
11ARAF1.82284095
12OXSR11.80302441
13PLK21.66867793
14KIT1.63480261
15PIM21.62701838
16BCR1.62664687
17STK391.53182799
18FGFR21.49352718
19TEC1.48583835
20NTRK31.48446931
21CHEK21.40582065
22EPHA41.39413650
23CAMK1G1.39293329
24EPHB21.36271515
25ZAK1.28044219
26MAP2K71.26226890
27MAP3K41.26039091
28TGFBR11.21436821
29PASK1.13884227
30DYRK21.10630209
31DYRK1B1.06718563
32INSRR1.04825982
33MAPK150.96593339
34PTK2B0.94115597
35MAP3K100.93222556
36PKN10.92865152
37PINK10.92033134
38MARK10.91226156
39MAPKAPK30.87148998
40TNK20.86810515
41BRSK20.84398132
42VRK20.81179003
43MINK10.80284832
44WNK30.80266046
45VRK10.78767901
46ATR0.76084086
47PRKD20.75937677
48BRAF0.73949813
49STK380.72402446
50KSR10.63604495
51MKNK20.62216935
52BCKDK0.61598266
53CAMK10.61292867
54BTK0.61018587
55TAF10.60884593
56PRKCH0.60721951
57IRAK20.60675851
58BRSK10.60043268
59MAP3K90.59496476
60PLK10.58388784
61UHMK10.57358040
62PLK30.54822718
63DDR20.54302081
64FLT30.54020944
65MAPK130.53738313
66EPHA30.53299493
67TLK10.53240181
68PRKCG0.51629682
69PIK3CG0.51345454
70CCNB10.50232474
71WNK40.50135818
72EEF2K0.49770723
73CDK90.48994072
74CSF1R0.48116881
75SIK30.45998499
76MAP4K20.44913610
77ERBB30.43754342
78MST1R0.41884388
79PAK30.41827796
80MAP4K10.39811643
81PIM10.39160250
82CDK20.37151877
83STK240.35539250
84PRKCI0.34542034
85SGK20.34333651
86ITK0.31563075
87STK110.31311681
88KDR0.31064659
89PRKCE0.30448737
90AURKB0.29452756
91ATM0.28414576
92CDK140.27531967
93MELK0.25982371
94CDK190.25196416
95SIK10.24821911
96AKT20.24262049
97CSNK1D0.23017004
98PHKG20.22942293
99PHKG10.22942293
100SGK2230.22741183

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.90411709
2Ribosome_Homo sapiens_hsa030104.12235487
3Base excision repair_Homo sapiens_hsa034103.38303088
4Homologous recombination_Homo sapiens_hsa034403.26058172
5Mismatch repair_Homo sapiens_hsa034303.11763868
6Nucleotide excision repair_Homo sapiens_hsa034202.97609126
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90627348
8Oxidative phosphorylation_Homo sapiens_hsa001902.55498628
9Fanconi anemia pathway_Homo sapiens_hsa034602.54573761
10Parkinsons disease_Homo sapiens_hsa050122.38622689
11Non-homologous end-joining_Homo sapiens_hsa034502.26657849
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19891259
13Primary immunodeficiency_Homo sapiens_hsa053402.17354396
14Caffeine metabolism_Homo sapiens_hsa002322.15692399
15Butanoate metabolism_Homo sapiens_hsa006502.10406591
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97676845
17Proteasome_Homo sapiens_hsa030501.97658808
18Phototransduction_Homo sapiens_hsa047441.80006542
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79295651
20Huntingtons disease_Homo sapiens_hsa050161.56913812
21Alzheimers disease_Homo sapiens_hsa050101.55573396
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55107409
23RNA transport_Homo sapiens_hsa030131.49965089
24Dorso-ventral axis formation_Homo sapiens_hsa043201.43861343
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31114986
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25999599
27Protein export_Homo sapiens_hsa030601.22039271
28Cardiac muscle contraction_Homo sapiens_hsa042601.21644488
29Systemic lupus erythematosus_Homo sapiens_hsa053221.16877566
30RNA degradation_Homo sapiens_hsa030181.13528536
31Oocyte meiosis_Homo sapiens_hsa041141.11369657
32Purine metabolism_Homo sapiens_hsa002301.10658869
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09126842
34Olfactory transduction_Homo sapiens_hsa047401.07679576
35Autoimmune thyroid disease_Homo sapiens_hsa053201.05405644
36Basal transcription factors_Homo sapiens_hsa030221.01799353
37Taste transduction_Homo sapiens_hsa047420.99600227
38Cell cycle_Homo sapiens_hsa041100.95315864
39Propanoate metabolism_Homo sapiens_hsa006400.94856404
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94200326
41Allograft rejection_Homo sapiens_hsa053300.94004750
42Peroxisome_Homo sapiens_hsa041460.92335756
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85161258
44Basal cell carcinoma_Homo sapiens_hsa052170.81412573
45Hedgehog signaling pathway_Homo sapiens_hsa043400.79724439
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78750157
47Alcoholism_Homo sapiens_hsa050340.77924475
48Fatty acid degradation_Homo sapiens_hsa000710.77156383
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74120290
50Pyrimidine metabolism_Homo sapiens_hsa002400.71149788
51Graft-versus-host disease_Homo sapiens_hsa053320.69506449
52One carbon pool by folate_Homo sapiens_hsa006700.69289195
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68981680
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65822980
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63797609
56TGF-beta signaling pathway_Homo sapiens_hsa043500.62537100
57Spliceosome_Homo sapiens_hsa030400.60200230
58Carbon metabolism_Homo sapiens_hsa012000.59406644
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57961442
60Fatty acid metabolism_Homo sapiens_hsa012120.56778382
61Type I diabetes mellitus_Homo sapiens_hsa049400.56295140
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.55257506
63Salivary secretion_Homo sapiens_hsa049700.53836191
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53760147
65Calcium signaling pathway_Homo sapiens_hsa040200.53390848
66p53 signaling pathway_Homo sapiens_hsa041150.51551727
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.51223576
68Lysine degradation_Homo sapiens_hsa003100.51016350
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50495596
70Nitrogen metabolism_Homo sapiens_hsa009100.50125838
71Asthma_Homo sapiens_hsa053100.47500376
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.47191790
73Wnt signaling pathway_Homo sapiens_hsa043100.46579133
74Viral carcinogenesis_Homo sapiens_hsa052030.46066171
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45809364
76Arginine and proline metabolism_Homo sapiens_hsa003300.45476911
77Viral myocarditis_Homo sapiens_hsa054160.41683493
78mRNA surveillance pathway_Homo sapiens_hsa030150.41380960
79Morphine addiction_Homo sapiens_hsa050320.40031358
80Axon guidance_Homo sapiens_hsa043600.37167334
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35524421
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35418539
83Metabolic pathways_Homo sapiens_hsa011000.35246550
84Circadian rhythm_Homo sapiens_hsa047100.30453514
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27565010
86Gap junction_Homo sapiens_hsa045400.26362914
87Hematopoietic cell lineage_Homo sapiens_hsa046400.25459636
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25364170
89Melanogenesis_Homo sapiens_hsa049160.25198174
90Glutathione metabolism_Homo sapiens_hsa004800.24196519
91Hippo signaling pathway_Homo sapiens_hsa043900.23360708
92Regulation of autophagy_Homo sapiens_hsa041400.23018987
93HTLV-I infection_Homo sapiens_hsa051660.18971470
94Circadian entrainment_Homo sapiens_hsa047130.18762070
95Chemical carcinogenesis_Homo sapiens_hsa052040.18076527
96RNA polymerase_Homo sapiens_hsa030200.17908585
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17576745
98ECM-receptor interaction_Homo sapiens_hsa045120.17551544
99Herpes simplex infection_Homo sapiens_hsa051680.17524926
100Pyruvate metabolism_Homo sapiens_hsa006200.17271106

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