ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of male gonad development (GO:2000020)	8.23766581
2	gonadal mesoderm development (GO:0007506)	8.09514039
3	regulation of male gonad development (GO:2000018)	6.60097025
4	regulation of female gonad development (GO:2000194)	6.25031564
5	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	6.22518500
6	sequestering of actin monomers (GO:0042989)	5.80745808
7	protein neddylation (GO:0045116)	5.75721916
8	cell morphogenesis involved in neuron differentiation (GO:0048667)	5.65877671
9	neural tube formation (GO:0001841)	5.45730073
10	cellular response to ATP (GO:0071318)	5.24177215
11	rRNA methylation (GO:0031167)	5.14039141
12	rRNA modification (GO:0000154)	5.11760117
13	negative regulation of DNA-templated transcription, elongation (GO:0032785)	5.02100397
14	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.65451290
15	post-embryonic morphogenesis (GO:0009886)	4.60014924
16	activated T cell proliferation (GO:0050798)	4.44685521
17	ventricular septum morphogenesis (GO:0060412)	4.35738385
18	spliceosomal tri-snRNP complex assembly (GO:0000244)	4.30884962
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.23834267
20	alanine transport (GO:0032328)	4.03637122
21	opioid receptor signaling pathway (GO:0038003)	3.92646071
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.89790222
23	ATP synthesis coupled proton transport (GO:0015986)	3.89790222
24	neuronal stem cell maintenance (GO:0097150)	3.89630285
25	forebrain neuron differentiation (GO:0021879)	3.88439497
26	genitalia morphogenesis (GO:0035112)	3.83293944
27	outflow tract septum morphogenesis (GO:0003148)	3.76573922
28	centriole replication (GO:0007099)	3.73887077
29	oxygen transport (GO:0015671)	3.72897739
30	pyrimidine nucleobase catabolic process (GO:0006208)	3.72862946
31	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.61956253
32	behavioral response to nicotine (GO:0035095)	3.51098271
33	appendage development (GO:0048736)	3.49905969
34	limb development (GO:0060173)	3.49905969
35	glycine transport (GO:0015816)	3.43649711
36	negative regulation of telomere maintenance (GO:0032205)	3.41214003
37	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.39523408
38	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.38856719
39	positive regulation of RNA splicing (GO:0033120)	3.35041970
40	retinal ganglion cell axon guidance (GO:0031290)	3.32903609
41	retinal cone cell development (GO:0046549)	3.32236403
42	negative regulation of mast cell activation (GO:0033004)	3.30439860
43	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.30208164
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.26453971
45	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.26453971
46	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.25675261
47	mannosylation (GO:0097502)	3.24868491
48	negative regulation of DNA recombination (GO:0045910)	3.16773652
49	negative regulation of epidermal cell differentiation (GO:0045605)	3.07820586
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06906965
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06906965
52	NADH dehydrogenase complex assembly (GO:0010257)	3.06906965
53	nucleobase catabolic process (GO:0046113)	3.05353650
54	mRNA splice site selection (GO:0006376)	2.88779996
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.86780088
56	DNA damage response, detection of DNA damage (GO:0042769)	2.86470831
57	fucose catabolic process (GO:0019317)	2.83281399
58	L-fucose metabolic process (GO:0042354)	2.83281399
59	L-fucose catabolic process (GO:0042355)	2.83281399
60	presynaptic membrane organization (GO:0097090)	2.83057711
61	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.79663309
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75990871
63	gas transport (GO:0015669)	2.75426598
64	sympathetic nervous system development (GO:0048485)	2.75366292
65	neuron fate determination (GO:0048664)	2.73212045
66	histone mRNA catabolic process (GO:0071044)	2.72230910
67	negative regulation of thymocyte apoptotic process (GO:0070244)	2.70621937
68	cerebral cortex radially oriented cell migration (GO:0021799)	2.68485290
69	alternative mRNA splicing, via spliceosome (GO:0000380)	2.68103594
70	somite development (GO:0061053)	2.67174791
71	ubiquinone metabolic process (GO:0006743)	2.63830460
72	hindbrain development (GO:0030902)	2.63780012
73	proline transport (GO:0015824)	2.61395538
74	protein targeting to Golgi (GO:0000042)	2.60935699
75	cellular response to zinc ion (GO:0071294)	2.60309667
76	L-methionine biosynthetic process (GO:0071265)	2.59747403
77	amino acid salvage (GO:0043102)	2.59747403
78	L-methionine salvage (GO:0071267)	2.59747403
79	reflex (GO:0060004)	2.59533302
80	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.59162694
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.58960806
82	cardiac muscle tissue development (GO:0048738)	2.57943813
83	neuron recognition (GO:0008038)	2.57812807
84	tRNA methylation (GO:0030488)	2.57053251
85	ventricular system development (GO:0021591)	2.56554421
86	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54675092
87	establishment of protein localization to Golgi (GO:0072600)	2.52393151
88	response to caffeine (GO:0031000)	2.50957939
89	lateral sprouting from an epithelium (GO:0060601)	2.49513077
90	central nervous system myelination (GO:0022010)	2.49410034
91	axon ensheathment in central nervous system (GO:0032291)	2.49410034
92	embryonic epithelial tube formation (GO:0001838)	2.49174465
93	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.48162520
94	response to magnesium ion (GO:0032026)	2.47863991
95	methionine biosynthetic process (GO:0009086)	2.46977726
96	protein complex biogenesis (GO:0070271)	2.45789415
97	negative regulation of epidermis development (GO:0045683)	2.44296641
98	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.44201972
99	nucleoside diphosphate phosphorylation (GO:0006165)	2.43856890
100	regulation of sarcomere organization (GO:0060297)	2.43722217

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.20892671
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.63293896
3	TAF15_26573619_Chip-Seq_HEK293_Human	3.12535795
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.03004375
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.96662930
6	EWS_26573619_Chip-Seq_HEK293_Human	2.94023077
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.77532003
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.62263386
9	FUS_26573619_Chip-Seq_HEK293_Human	2.44854378
10	P300_19829295_ChIP-Seq_ESCs_Human	2.40175171
11	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.36156721
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.21003905
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.19696672
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15779015
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.12672372
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12323211
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04577214
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00712539
19	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.97759427
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.89195534
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.86467577
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84663686
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82994282
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.82238620
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.77572569
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76158363
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.76158363
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.75809117
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.74491548
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.74379754
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.73998343
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69409541
33	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.69230192
34	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.67033115
35	AR_25329375_ChIP-Seq_VCAP_Human	1.66918258
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.66394654
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.59988836
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59217051
39	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.57922659
40	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.56155176
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.53725008
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47572754
43	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.46825972
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46496776
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43966960
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43742379
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36103013
48	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.35698642
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.35459127
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35459127
51	VDR_22108803_ChIP-Seq_LS180_Human	1.34681288
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33701466
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32228795
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29643053
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.28165868
56	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27916674
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27356553
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25271155
59	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.25071494
60	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.25071494
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24468650
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.24031895
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23585925
64	VDR_23849224_ChIP-Seq_CD4+_Human	1.21996706
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20308672
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17952579
67	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.17552548
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17172390
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.16951969
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16380094
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15995498
72	STAT3_23295773_ChIP-Seq_U87_Human	1.15890207
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15138013
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14598985
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14176134
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.12943640
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12285924
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.09394717
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08968441
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08500200
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08427813
82	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08427813
83	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08149031
84	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06291827
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06099522
86	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04790872
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04472242
88	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02404421
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02334585
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01854494
91	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.01826919
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01479635
93	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01357964
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00177101
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.99716177
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99322527
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.98458100
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98253721
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97003873
100	TTF2_22483619_ChIP-Seq_HELA_Human	0.96733825

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.95385987
2	MP0009379_abnormal_foot_pigmentation	3.79547987
3	MP0006072_abnormal_retinal_apoptosis	3.70605949
4	MP0005253_abnormal_eye_physiology	3.20526300
5	MP0005646_abnormal_pituitary_gland	3.15662388
6	MP0003878_abnormal_ear_physiology	3.08840563
7	MP0005377_hearing/vestibular/ear_phenot	3.08840563
8	MP0004215_abnormal_myocardial_fiber	2.54117142
9	MP0001188_hyperpigmentation	2.43163541
10	MP0006292_abnormal_olfactory_placode	2.42412291
11	MP0010368_abnormal_lymphatic_system	2.31507876
12	MP0001293_anophthalmia	2.26916749
13	MP0003638_abnormal_response/metabolism_	2.09666281
14	MP0000516_abnormal_urinary_system	2.07865359
15	MP0005367_renal/urinary_system_phenotyp	2.07865359
16	MP0002127_abnormal_cardiovascular_syste	2.07130819
17	MP0002163_abnormal_gland_morphology	2.06777797
18	MP0005423_abnormal_somatic_nervous	2.03685780
19	MP0000372_irregular_coat_pigmentation	1.96619566
20	MP0004142_abnormal_muscle_tone	1.89036329
21	MP0002736_abnormal_nociception_after	1.88465270
22	MP0005379_endocrine/exocrine_gland_phen	1.87114475
23	MP0005391_vision/eye_phenotype	1.85411657
24	MP0004742_abnormal_vestibular_system	1.82170662
25	MP0005551_abnormal_eye_electrophysiolog	1.81756494
26	MP0001440_abnormal_grooming_behavior	1.73197167
27	MP0001529_abnormal_vocalization	1.66972392
28	MP0001502_abnormal_circadian_rhythm	1.62267744
29	MP0002272_abnormal_nervous_system	1.56242316
30	MP0005197_abnormal_uvea_morphology	1.53917766
31	MP0001879_abnormal_lymphatic_vessel	1.52731641
32	MP0001968_abnormal_touch/_nociception	1.51297161
33	MP0008995_early_reproductive_senescence	1.48874402
34	MP0003937_abnormal_limbs/digits/tail_de	1.47756674
35	MP0003724_increased_susceptibility_to	1.45292930
36	MP0002572_abnormal_emotion/affect_behav	1.44649087
37	MP0000778_abnormal_nervous_system	1.44083767
38	MP0002234_abnormal_pharynx_morphology	1.43957275
39	MP0002557_abnormal_social/conspecific_i	1.39085493
40	MP0003011_delayed_dark_adaptation	1.38312371
41	MP0003786_premature_aging	1.30825902
42	MP0005595_abnormal_vascular_smooth	1.30170067
43	MP0002090_abnormal_vision	1.26439006
44	MP0002735_abnormal_chemical_nociception	1.24346188
45	MP0000631_abnormal_neuroendocrine_gland	1.23603138
46	MP0004085_abnormal_heartbeat	1.21375017
47	MP0001905_abnormal_dopamine_level	1.21244665
48	MP0008775_abnormal_heart_ventricle	1.16909143
49	MP0006276_abnormal_autonomic_nervous	1.13868652
50	MP0005410_abnormal_fertilization	1.13058125
51	MP0006035_abnormal_mitochondrial_morpho	1.13024141
52	MP0008877_abnormal_DNA_methylation	1.12172579
53	MP0010030_abnormal_orbit_morphology	1.11554469
54	MP0003880_abnormal_central_pattern	1.10529058
55	MP0002067_abnormal_sensory_capabilities	1.07623805
56	MP0001485_abnormal_pinna_reflex	1.07560818
57	MP0005174_abnormal_tail_pigmentation	1.07078191
58	MP0003567_abnormal_fetal_cardiomyocyte	1.05984925
59	MP0000230_abnormal_systemic_arterial	1.05906897
60	MP0004859_abnormal_synaptic_plasticity	1.04092084
61	MP0008875_abnormal_xenobiotic_pharmacok	1.03281955
62	MP0003646_muscle_fatigue	1.03188207
63	MP0002938_white_spotting	1.02419590
64	MP0000049_abnormal_middle_ear	1.02186157
65	MP0008872_abnormal_physiological_respon	1.00974873
66	MP0004043_abnormal_pH_regulation	1.00765218
67	MP0008058_abnormal_DNA_repair	0.97063183
68	MP0003718_maternal_effect	0.95325793
69	MP0006138_congestive_heart_failure	0.94740348
70	MP0003959_abnormal_lean_body	0.94605945
71	MP0002063_abnormal_learning/memory/cond	0.92947883
72	MP0005195_abnormal_posterior_eye	0.91961629
73	MP0005187_abnormal_penis_morphology	0.91527456
74	MP0009745_abnormal_behavioral_response	0.91267216
75	MP0005084_abnormal_gallbladder_morpholo	0.89273294
76	MP0003890_abnormal_embryonic-extraembry	0.85680098
77	MP0003635_abnormal_synaptic_transmissio	0.84432932
78	MP0002233_abnormal_nose_morphology	0.83530129
79	MP0004133_heterotaxia	0.82975785
80	MP0005394_taste/olfaction_phenotype	0.82779606
81	MP0005499_abnormal_olfactory_system	0.82779606
82	MP0001348_abnormal_lacrimal_gland	0.82326010
83	MP0009046_muscle_twitch	0.81902967
84	MP0003122_maternal_imprinting	0.81217504
85	MP0001119_abnormal_female_reproductive	0.75150684
86	MP0001986_abnormal_taste_sensitivity	0.74509316
87	MP0003115_abnormal_respiratory_system	0.74241200
88	MP0003755_abnormal_palate_morphology	0.73917325
89	MP0002734_abnormal_mechanical_nocicepti	0.73753938
90	MP0001286_abnormal_eye_development	0.72840106
91	MP0001542_abnormal_bone_strength	0.72635499
92	MP0004885_abnormal_endolymph	0.72126316
93	MP0004883_abnormal_blood_vessel	0.71810251
94	MP0003121_genomic_imprinting	0.71065816
95	MP0002102_abnormal_ear_morphology	0.70465624
96	MP0005620_abnormal_muscle_contractility	0.69955481
97	MP0000647_abnormal_sebaceous_gland	0.69905983
98	MP0002282_abnormal_trachea_morphology	0.67851074
99	MP0002837_dystrophic_cardiac_calcinosis	0.67685677
100	MP0003136_yellow_coat_color	0.66133378

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.49971101
2	Abdominal situs inversus (HP:0003363)	5.77200504
3	Abnormality of abdominal situs (HP:0011620)	5.77200504
4	High anterior hairline (HP:0009890)	5.56747071
5	Sclerocornea (HP:0000647)	5.03325885
6	Abnormality of midbrain morphology (HP:0002418)	3.99221905
7	Molar tooth sign on MRI (HP:0002419)	3.99221905
8	Pancreatic cysts (HP:0001737)	3.88796803
9	Septate vagina (HP:0001153)	3.82873509
10	Abnormal hemoglobin (HP:0011902)	3.69173943
11	Skull defect (HP:0001362)	3.54105905
12	Preaxial hand polydactyly (HP:0001177)	3.37282370
13	Bifid tongue (HP:0010297)	3.34309067
14	Pancreatic fibrosis (HP:0100732)	3.23398969
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.18506915
16	True hermaphroditism (HP:0010459)	3.14907402
17	Increased serum pyruvate (HP:0003542)	3.14590678
18	Nephronophthisis (HP:0000090)	3.12015069
19	Pendular nystagmus (HP:0012043)	2.95051977
20	Anophthalmia (HP:0000528)	2.89249245
21	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.76733124
22	Renal cortical cysts (HP:0000803)	2.71335996
23	Cystic liver disease (HP:0006706)	2.59276974
24	Spastic tetraparesis (HP:0001285)	2.57336407
25	Lissencephaly (HP:0001339)	2.53085694
26	Abnormality of the renal medulla (HP:0100957)	2.52119925
27	Highly arched eyebrow (HP:0002553)	2.49927473
28	Abnormality of glycolysis (HP:0004366)	2.49636583
29	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.45346325
30	Hypoplasia of the brainstem (HP:0002365)	2.45346325
31	Megalocornea (HP:0000485)	2.45090453
32	Anencephaly (HP:0002323)	2.43062799
33	Growth hormone deficiency (HP:0000824)	2.38923441
34	Congenital diaphragmatic hernia (HP:0000776)	2.36452172
35	Mesomelia (HP:0003027)	2.27079374
36	Increased number of teeth (HP:0011069)	2.25507823
37	Delayed CNS myelination (HP:0002188)	2.25269295
38	Hypothermia (HP:0002045)	2.23451266
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21486616
40	Abnormality of the labia minora (HP:0012880)	2.20503997
41	Acute necrotizing encephalopathy (HP:0006965)	2.19807684
42	Increased hepatocellular lipid droplets (HP:0006565)	2.19361896
43	Facial hemangioma (HP:0000329)	2.14547562
44	Optic nerve coloboma (HP:0000588)	2.14357074
45	Duplicated collecting system (HP:0000081)	2.13998439
46	Preauricular pit (HP:0004467)	2.12263004
47	Periauricular skin pits (HP:0100277)	2.12263004
48	Iris coloboma (HP:0000612)	2.11332930
49	Progressive macrocephaly (HP:0004481)	2.10092855
50	Exertional dyspnea (HP:0002875)	2.10002779
51	Heterotopia (HP:0002282)	2.09664002
52	Choroideremia (HP:0001139)	2.08091040
53	Oligodontia (HP:0000677)	2.05250824
54	Pachygyria (HP:0001302)	2.02338586
55	Submucous cleft hard palate (HP:0000176)	2.00969420
56	Disproportionate tall stature (HP:0001519)	2.00484527
57	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.98522256
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98279503
59	Depressed nasal tip (HP:0000437)	1.98218474
60	Abnormal number of incisors (HP:0011064)	1.97959333
61	Thyroid-stimulating hormone excess (HP:0002925)	1.97353781
62	Mitochondrial inheritance (HP:0001427)	1.96346758
63	Congenital, generalized hypertrichosis (HP:0004540)	1.95987542
64	Abnormal ciliary motility (HP:0012262)	1.95555958
65	Abnormality of the renal cortex (HP:0011035)	1.94984485
66	Hepatic necrosis (HP:0002605)	1.94737199
67	Sacral dimple (HP:0000960)	1.93345277
68	Tubulointerstitial nephritis (HP:0001970)	1.90605772
69	Hyperglycinuria (HP:0003108)	1.86014620
70	Medulloblastoma (HP:0002885)	1.84994986
71	Abnormality of the renal collecting system (HP:0004742)	1.82366570
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81105890
73	Increased CSF lactate (HP:0002490)	1.80423930
74	Skin pits (HP:0100276)	1.79410072
75	Hypoplasia of the uterus (HP:0000013)	1.79203940
76	Renal Fanconi syndrome (HP:0001994)	1.79191784
77	Generalized aminoaciduria (HP:0002909)	1.79180217
78	Fair hair (HP:0002286)	1.78692800
79	Patellar aplasia (HP:0006443)	1.77618260
80	Hepatocellular necrosis (HP:0001404)	1.76499609
81	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76313478
82	Abnormality of alanine metabolism (HP:0010916)	1.76313478
83	Hyperalaninemia (HP:0003348)	1.76313478
84	Midline defect of the nose (HP:0004122)	1.76122861
85	Cerebral hypomyelination (HP:0006808)	1.75159819
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.73742639
87	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.73742639
88	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.73505380
89	Hypoplastic labia majora (HP:0000059)	1.73065289
90	Aplasia/Hypoplasia of the patella (HP:0006498)	1.72961096
91	Acute encephalopathy (HP:0006846)	1.72860745
92	Furrowed tongue (HP:0000221)	1.72759196
93	Alopecia of scalp (HP:0002293)	1.70853297
94	Abnormal rod and cone electroretinograms (HP:0008323)	1.70066437
95	Polyphagia (HP:0002591)	1.69248444
96	Median cleft lip (HP:0000161)	1.69078250
97	Dyschromatopsia (HP:0007641)	1.68962137
98	Lipid accumulation in hepatocytes (HP:0006561)	1.66564078
99	Chorioretinal coloboma (HP:0000567)	1.65962310
100	Hypoplastic pelvis (HP:0008839)	1.65577801

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	5.60525444
2	PNCK	4.36665551
3	MAP4K2	3.90959441
4	MAPK13	3.26196755
5	TSSK6	2.98613969
6	TAOK3	2.38604964
7	MKNK2	2.28938746
8	TGFBR1	2.17214818
9	WEE1	1.96355755
10	MARK1	1.89725254
11	PLK4	1.88095155
12	WNK3	1.80879237
13	TRIM28	1.76554764
14	NUAK1	1.73467327
15	EIF2AK3	1.71988171
16	TESK1	1.68244774
17	PHKG2	1.66836077
18	PHKG1	1.66836077
19	INSRR	1.65257755
20	MKNK1	1.62861531
21	EIF2AK1	1.60422275
22	PLK3	1.59823401
23	PIK3CA	1.49746745
24	ZAK	1.46521693
25	MINK1	1.44817953
26	SIK2	1.36653252
27	DYRK2	1.35840579
28	MAP3K4	1.31353381
29	NME1	1.26228649
30	NTRK2	1.24690998
31	LIMK1	1.20639878
32	SRPK1	1.20137391
33	BCR	1.18918004
34	BRSK2	1.07168210
35	WNK4	1.04630440
36	BRSK1	0.98140745
37	CSNK1G1	0.97960349
38	MAP2K7	0.96694857
39	EIF2AK2	0.96355693
40	BUB1	0.93475649
41	CAMK1G	0.92864865
42	STK16	0.91466897
43	CAMK2A	0.91379059
44	CHEK2	0.89931787
45	CSNK1G2	0.86956821
46	CAMKK2	0.84635854
47	NEK1	0.80196560
48	FRK	0.75682776
49	PKN1	0.74939788
50	MAPK15	0.74250815
51	ILK	0.74069827
52	CCNB1	0.73669043
53	TEC	0.72476077
54	PIK3CG	0.72308036
55	ADRBK2	0.71889660
56	PTK2B	0.68664106
57	PLK2	0.68646048
58	PRKCE	0.67614507
59	PRKCG	0.63947691
60	CDC7	0.63071810
61	CAMK1	0.63071306
62	YES1	0.62679310
63	AURKA	0.60135016
64	TNIK	0.58707638
65	ERBB3	0.58256296
66	ATM	0.55879041
67	TLK1	0.55283161
68	SIK3	0.53444358
69	TESK2	0.53231502
70	EPHB2	0.51898944
71	RPS6KB2	0.49574816
72	EPHA3	0.46914803
73	PAK3	0.45540858
74	PRKACA	0.45294288
75	BTK	0.45207146
76	PRKACG	0.42927390
77	BMPR1B	0.41613413
78	PRKCB	0.40876965
79	IKBKB	0.39780645
80	DAPK2	0.39295061
81	MAP3K14	0.38755445
82	IKBKE	0.38671939
83	CSNK1G3	0.38262257
84	STK39	0.37080092
85	PRKACB	0.36690528
86	VRK1	0.35691467
87	MAPKAPK3	0.35292587
88	SGK2	0.34984907
89	TRPM7	0.34921918
90	PLK1	0.34064778
91	CAMK4	0.33738127
92	LATS2	0.33402702
93	PASK	0.33394932
94	PRKCI	0.31448641
95	TIE1	0.30187561
96	BRD4	0.29978301
97	CSNK1E	0.28829359
98	LRRK2	0.27699826
99	MAPKAPK5	0.27513879
100	SYK	0.26352004

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.15489114
2	Phototransduction_Homo sapiens_hsa04744	3.14075940
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.92059119
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.90370219
5	Proteasome_Homo sapiens_hsa03050	2.65597015
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.46518766
7	Spliceosome_Homo sapiens_hsa03040	2.40548277
8	Parkinsons disease_Homo sapiens_hsa05012	2.28281841
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28213386
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.27825719
11	Nicotine addiction_Homo sapiens_hsa05033	2.11445786
12	Ribosome_Homo sapiens_hsa03010	2.09948337
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.88240503
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.80112310
15	Butanoate metabolism_Homo sapiens_hsa00650	1.78225092
16	Propanoate metabolism_Homo sapiens_hsa00640	1.72608012
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.66385110
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.66295219
19	Huntingtons disease_Homo sapiens_hsa05016	1.63740644
20	Alzheimers disease_Homo sapiens_hsa05010	1.59131829
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.57927845
22	One carbon pool by folate_Homo sapiens_hsa00670	1.52579044
23	RNA polymerase_Homo sapiens_hsa03020	1.52142402
24	Asthma_Homo sapiens_hsa05310	1.50498520
25	RNA transport_Homo sapiens_hsa03013	1.43345813
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42314467
27	Folate biosynthesis_Homo sapiens_hsa00790	1.41726410
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39184553
29	Caffeine metabolism_Homo sapiens_hsa00232	1.32529647
30	RNA degradation_Homo sapiens_hsa03018	1.30048146
31	Circadian entrainment_Homo sapiens_hsa04713	1.27968524
32	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.20637750
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19662179
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.17726228
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13984033
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12675372
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08198827
38	Homologous recombination_Homo sapiens_hsa03440	1.07465646
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.06561771
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05974515
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03267235
42	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.02395834
43	Salivary secretion_Homo sapiens_hsa04970	1.01485924
44	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.98767989
45	Taste transduction_Homo sapiens_hsa04742	0.97215220
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.95326371
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93154102
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90630654
49	Purine metabolism_Homo sapiens_hsa00230	0.89024372
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.87593956
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.85267386
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.84016441
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81840828
54	Mismatch repair_Homo sapiens_hsa03430	0.81232986
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79944432
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77553218
57	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75391279
58	GABAergic synapse_Homo sapiens_hsa04727	0.73789219
59	Olfactory transduction_Homo sapiens_hsa04740	0.72259219
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71900140
61	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.70576824
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67791089
63	Serotonergic synapse_Homo sapiens_hsa04726	0.67617449
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65881136
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.64533514
66	Morphine addiction_Homo sapiens_hsa05032	0.63798790
67	Metabolic pathways_Homo sapiens_hsa01100	0.63369662
68	Cocaine addiction_Homo sapiens_hsa05030	0.61779825
69	Cell cycle_Homo sapiens_hsa04110	0.60471993
70	Mineral absorption_Homo sapiens_hsa04978	0.59570870
71	MicroRNAs in cancer_Homo sapiens_hsa05206	0.58929190
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58860283
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.58684193
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55520120
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55135535
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54726716
77	Peroxisome_Homo sapiens_hsa04146	0.53089712
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.51324740
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.50717918
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.50048491
81	DNA replication_Homo sapiens_hsa03030	0.48539672
82	Fatty acid degradation_Homo sapiens_hsa00071	0.46781074
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.45887367
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45057246
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44752188
86	Sulfur relay system_Homo sapiens_hsa04122	0.44572035
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42875005
88	Allograft rejection_Homo sapiens_hsa05330	0.42358396
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42001404
90	Sulfur metabolism_Homo sapiens_hsa00920	0.41427191
91	Long-term depression_Homo sapiens_hsa04730	0.41316791
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.40869280
93	Insulin secretion_Homo sapiens_hsa04911	0.40450681
94	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.38919366
95	Regulation of autophagy_Homo sapiens_hsa04140	0.38122807
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36911189
97	Base excision repair_Homo sapiens_hsa03410	0.36228416
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.35498981
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.34968571
100	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.34409603

HMGB3P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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