ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of natural killer cell mediated immunity (GO:0002717)	6.93788795
2	positive regulation of monocyte chemotaxis (GO:0090026)	6.85654132
3	regulation of activation of Janus kinase activity (GO:0010533)	6.74683129
4	regulation of natural killer cell mediated immunity (GO:0002715)	6.70546452
5	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	6.70546452
6	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	6.64510016
7	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	6.62436144
8	negative regulation of cell killing (GO:0031342)	6.62436144
9	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.49631878
10	DNA deamination (GO:0045006)	5.42681767
11	cellular response to interleukin-15 (GO:0071350)	5.42137679
12	regulation of isotype switching to IgG isotypes (GO:0048302)	5.31659656
13	interferon-gamma production (GO:0032609)	5.28473985
14	response to interleukin-15 (GO:0070672)	5.18335332
15	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	5.10928267
16	cytidine metabolic process (GO:0046087)	5.09029233
17	cytidine catabolic process (GO:0006216)	5.09029233
18	cytidine deamination (GO:0009972)	5.09029233
19	regulation of leukocyte mediated cytotoxicity (GO:0001910)	5.03105925
20	negative thymic T cell selection (GO:0045060)	4.97405978
21	negative T cell selection (GO:0043383)	4.67996123
22	regulation of monocyte chemotaxis (GO:0090025)	4.66748982
23	monocyte chemotaxis (GO:0002548)	4.64075354
24	positive regulation of cell killing (GO:0031343)	4.60308587
25	regulation of cell killing (GO:0031341)	4.55991823
26	dendritic cell chemotaxis (GO:0002407)	4.52544724
27	negative regulation of type 2 immune response (GO:0002829)	4.48061240
28	rRNA catabolic process (GO:0016075)	4.43472189
29	regulation of regulatory T cell differentiation (GO:0045589)	4.42969113
30	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.36446841
31	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	4.26331348
32	eosinophil chemotaxis (GO:0048245)	4.21594523
33	B cell mediated immunity (GO:0019724)	4.21277749
34	regulation of chronic inflammatory response (GO:0002676)	4.17950485
35	regulation of B cell receptor signaling pathway (GO:0050855)	4.13676889
36	positive regulation of gamma-delta T cell activation (GO:0046645)	4.11327019
37	negative regulation of T cell apoptotic process (GO:0070233)	4.05548555
38	positive regulation of T cell cytokine production (GO:0002726)	3.98338193
39	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.97785443
40	antigen processing and presentation of endogenous antigen (GO:0019883)	3.95365348
41	positive regulation of T cell chemotaxis (GO:0010820)	3.94048455
42	regulation of T cell chemotaxis (GO:0010819)	3.94048455
43	regulation of T cell tolerance induction (GO:0002664)	3.89572225
44	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.88570714
45	regulation of T cell mediated cytotoxicity (GO:0001914)	3.87052814
46	positive regulation of B cell differentiation (GO:0045579)	3.84734599
47	cellular defense response (GO:0006968)	3.81709195
48	eosinophil migration (GO:0072677)	3.78831805
49	lymphocyte apoptotic process (GO:0070227)	3.77799407
50	negative regulation of B cell activation (GO:0050869)	3.76734194
51	dendritic cell migration (GO:0036336)	3.76171207
52	positive regulation of T-helper 1 type immune response (GO:0002827)	3.67712237
53	mitochondrial calcium ion transport (GO:0006851)	3.62071463
54	positive regulation of lymphocyte mediated immunity (GO:0002708)	3.59627475
55	regulation of gamma-delta T cell differentiation (GO:0045586)	3.57038950
56	thymic T cell selection (GO:0045061)	3.56934849
57	regulation of lymphocyte mediated immunity (GO:0002706)	3.56457843
58	negative regulation of B cell proliferation (GO:0030889)	3.45018618
59	activated T cell proliferation (GO:0050798)	3.41658527
60	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.41309493
61	positive regulation of T cell mediated immunity (GO:0002711)	3.39819114
62	positive regulation of interleukin-4 production (GO:0032753)	3.35665938
63	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.33839507
64	regulation of B cell differentiation (GO:0045577)	3.33595413
65	positive regulation of translational initiation (GO:0045948)	3.27431906
66	positive regulation of leukocyte mediated immunity (GO:0002705)	3.27203963
67	N-acetylneuraminate metabolic process (GO:0006054)	3.26896778
68	regulation of macrophage chemotaxis (GO:0010758)	3.25069068
69	regulation of tolerance induction (GO:0002643)	3.24347768
70	positive thymic T cell selection (GO:0045059)	3.23269962
71	regulation of gamma-delta T cell activation (GO:0046643)	3.20436939
72	positive regulation of tolerance induction (GO:0002645)	3.19446756
73	negative regulation of lymphocyte mediated immunity (GO:0002707)	3.17841146
74	negative regulation of viral genome replication (GO:0045071)	3.17231817
75	regulation of leukocyte mediated immunity (GO:0002703)	3.15662294
76	regulation of T-helper 1 type immune response (GO:0002825)	3.14740931
77	positive regulation of interferon-gamma production (GO:0032729)	3.13889885
78	macrophage chemotaxis (GO:0048246)	3.11415986
79	regulation of mononuclear cell migration (GO:0071675)	3.10418272
80	negative regulation of leukocyte mediated immunity (GO:0002704)	3.09202126
81	regulation of T cell mediated immunity (GO:0002709)	3.07809806
82	antigen processing and presentation via MHC class Ib (GO:0002475)	3.04623871
83	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.03831150
84	negative regulation by host of viral transcription (GO:0043922)	3.02890199
85	regulation of B cell activation (GO:0050864)	3.02672375
86	neutrophil activation (GO:0042119)	2.99930309
87	negative regulation of innate immune response (GO:0045824)	2.99895958
88	positive regulation of defense response to virus by host (GO:0002230)	2.98308580
89	regulation of interferon-beta biosynthetic process (GO:0045357)	2.95680262
90	negative regulation of interleukin-17 production (GO:0032700)	2.94701495
91	T cell selection (GO:0045058)	2.94317505
92	regulation of isotype switching (GO:0045191)	2.92835813
93	leukocyte apoptotic process (GO:0071887)	2.91717861
94	positive regulation of adaptive immune response based on somatic recombination of immune receptors b	2.87459957
95	regulation of T cell cytokine production (GO:0002724)	2.86546422
96	regulation of immunoglobulin production (GO:0002637)	2.85332654
97	cytolysis (GO:0019835)	2.83185111
98	granulocyte activation (GO:0036230)	2.83121817
99	natural killer cell activation (GO:0030101)	2.82417105
100	macroautophagy (GO:0016236)	2.80400511

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	5.68225699
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.42863514
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.68011305
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	4.55954621
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.46324609
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	4.30536161
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.00273687
8	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.22775076
9	MYB_26560356_Chip-Seq_TH2_Human	2.89406389
10	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	2.81468181
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.80306082
12	RUNX_20019798_ChIP-Seq_JUKART_Human	2.70340844
13	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.63697171
14	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.56660512
15	STAT4_19710469_ChIP-ChIP_TH1__Mouse	2.48429939
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.39878311
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.27975541
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.15767467
19	GATA3_26560356_Chip-Seq_TH2_Human	2.15371392
20	MYB_26560356_Chip-Seq_TH1_Human	2.12846829
21	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	2.07681997
22	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.06500104
23	GATA3_27048872_Chip-Seq_THYMUS_Human	1.99330428
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96490487
25	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.85368839
26	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.83951241
27	MAF_26560356_Chip-Seq_TH2_Human	1.75457094
28	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.67884757
29	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.66134571
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62039012
31	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.60881090
32	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.60603966
33	UTX_26944678_Chip-Seq_JUKART_Human	1.59043940
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54866894
35	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.52917752
36	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.50727673
37	SPI1_23547873_ChIP-Seq_NB4_Human	1.49865195
38	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.48823528
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.48305426
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46473544
41	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.44450374
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42618354
43	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.41804629
44	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.32075969
45	SPI1_23127762_ChIP-Seq_K562_Human	1.30895093
46	MAF_26560356_Chip-Seq_TH1_Human	1.26329618
47	GATA1_22025678_ChIP-Seq_K562_Human	1.25531548
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.25391865
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20943842
50	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.17308973
51	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.15187505
52	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.14977850
53	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.08790856
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.06344221
55	CIITA_25753668_ChIP-Seq_RAJI_Human	1.05895577
56	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04468847
57	GATA3_26560356_Chip-Seq_TH1_Human	1.04337105
58	TP53_16413492_ChIP-PET_HCT116_Human	1.04256195
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02790626
60	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00661351
61	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.99163056
62	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.97228582
63	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95367108
64	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.93298860
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90959382
66	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87877008
67	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.87730091
68	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.87586045
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87101010
70	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.86494820
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85650706
72	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.84187972
73	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.83932823
74	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.83932823
75	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.83932823
76	BCL6_27268052_Chip-Seq_Bcells_Human	0.82958714
77	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.82404814
78	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.82206984
79	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.80326069
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.79872947
81	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.78889050
82	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.77642992
83	AR_20517297_ChIP-Seq_VCAP_Human	0.77274583
84	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.76827467
85	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.76810740
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.76111220
87	HTT_18923047_ChIP-ChIP_STHdh_Human	0.74946717
88	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.74328819
89	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.74165427
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.73014038
91	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.72923341
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.72860401
93	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.72004662
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.71649145
95	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.71444646
96	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.71242258
97	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.70864443
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.70266043
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.70195787
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.69755706

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.73420784
2	MP0002163_abnormal_gland_morphology	3.42753644
3	MP0006082_CNS_inflammation	3.31921114
4	MP0000685_abnormal_immune_system	3.26110010
5	MP0009785_altered_susceptibility_to	3.19277396
6	MP0001835_abnormal_antigen_presentation	3.16586609
7	MP0005000_abnormal_immune_tolerance	3.07744537
8	MP0003763_abnormal_thymus_physiology	2.93553230
9	MP0001800_abnormal_humoral_immune	2.86697896
10	MP0001790_abnormal_immune_system	2.80812547
11	MP0005387_immune_system_phenotype	2.80812547
12	MP0002723_abnormal_immune_serum	2.80331873
13	MP0003172_abnormal_lysosome_physiology	2.77540709
14	MP0005025_abnormal_response_to	2.73776193
15	MP0002148_abnormal_hypersensitivity_rea	2.63697381
16	MP0002420_abnormal_adaptive_immunity	2.54294189
17	MP0001819_abnormal_immune_cell	2.52976156
18	MP0003436_decreased_susceptibility_to	2.39331205
19	MP0002405_respiratory_system_inflammati	2.38050353
20	MP0002419_abnormal_innate_immunity	2.32113902
21	MP0004947_skin_inflammation	2.32009642
22	MP0005464_abnormal_platelet_physiology	2.17513427
23	MP0002452_abnormal_antigen_presenting	2.16807363
24	MP0005075_abnormal_melanosome_morpholog	2.08170616
25	MP0002876_abnormal_thyroid_physiology	2.05717657
26	MP0006072_abnormal_retinal_apoptosis	2.05389599
27	MP0002398_abnormal_bone_marrow	2.03731667
28	MP0005379_endocrine/exocrine_gland_phen	2.01533208
29	MP0002653_abnormal_ependyma_morphology	1.95667743
30	MP0000716_abnormal_immune_system	1.90354099
31	MP0002132_abnormal_respiratory_system	1.88938708
32	MP0001873_stomach_inflammation	1.85348139
33	MP0003724_increased_susceptibility_to	1.84853462
34	MP0001348_abnormal_lacrimal_gland	1.83935773
35	MP0002722_abnormal_immune_system	1.83077761
36	MP0009333_abnormal_splenocyte_physiolog	1.81091203
37	MP0001188_hyperpigmentation	1.80056900
38	MP0000689_abnormal_spleen_morphology	1.79957044
39	MP0001845_abnormal_inflammatory_respons	1.79701466
40	MP0002138_abnormal_hepatobiliary_system	1.69390374
41	MP0003045_fibrosis	1.69112275
42	MP0000703_abnormal_thymus_morphology	1.66226534
43	MP0010155_abnormal_intestine_physiology	1.65794130
44	MP0002429_abnormal_blood_cell	1.51047857
45	MP0003866_abnormal_defecation	1.48885683
46	MP0009764_decreased_sensitivity_to	1.48331566
47	MP0008469_abnormal_protein_level	1.38125718
48	MP0010307_abnormal_tumor_latency	1.34705486
49	MP0005310_abnormal_salivary_gland	1.34481002
50	MP0001533_abnormal_skeleton_physiology	1.33250187
51	MP0003195_calcinosis	1.30810268
52	MP0003191_abnormal_cellular_cholesterol	1.30109688
53	MP0008875_abnormal_xenobiotic_pharmacok	1.28217591
54	MP0001501_abnormal_sleep_pattern	1.28217577
55	MP0002693_abnormal_pancreas_physiology	1.19133977
56	MP0001346_abnormal_lacrimal_gland	1.10401018
57	MP0009765_abnormal_xenobiotic_induced	1.02174289
58	MP0004145_abnormal_muscle_electrophysio	1.00342970
59	MP0008873_increased_physiological_sensi	0.99710670
60	MP0009840_abnormal_foam_cell	0.90785465
61	MP0001853_heart_inflammation	0.88357581
62	MP0009780_abnormal_chondrocyte_physiolo	0.87563255
63	MP0009763_increased_sensitivity_to	0.87290205
64	MP0003448_altered_tumor_morphology	0.82750862
65	MP0003183_abnormal_peptide_metabolism	0.80743474
66	MP0000015_abnormal_ear_pigmentation	0.79406477
67	MP0001986_abnormal_taste_sensitivity	0.79022296
68	MP0000427_abnormal_hair_cycle	0.78287848
69	MP0001905_abnormal_dopamine_level	0.78256969
70	MP0002933_joint_inflammation	0.72971342
71	MP0000858_altered_metastatic_potential	0.70613115
72	MP0002019_abnormal_tumor_incidence	0.69430613
73	MP0000372_irregular_coat_pigmentation	0.68924894
74	MP0004381_abnormal_hair_follicle	0.68468500
75	MP0000920_abnormal_myelination	0.68359036
76	MP0000383_abnormal_hair_follicle	0.66400092
77	MP0000681_abnormal_thyroid_gland	0.65810590
78	MP0000371_diluted_coat_color	0.65710446
79	MP0008260_abnormal_autophagy	0.65237755
80	MP0002877_abnormal_melanocyte_morpholog	0.63703927
81	MP0003300_gastrointestinal_ulcer	0.63055612
82	MP0001944_abnormal_pancreas_morphology	0.61160776
83	MP0003075_altered_response_to	0.60253094
84	MP0004043_abnormal_pH_regulation	0.59249063
85	MP0004484_altered_response_of	0.57173229
86	MP0005253_abnormal_eye_physiology	0.52551785
87	MP0001919_abnormal_reproductive_system	0.51589330
88	MP0005083_abnormal_biliary_tract	0.51339667
89	MP0008874_decreased_physiological_sensi	0.50107438
90	MP0000249_abnormal_blood_vessel	0.49522487
91	MP0008007_abnormal_cellular_replicative	0.49237191
92	MP0005646_abnormal_pituitary_gland	0.48618992
93	MP0001191_abnormal_skin_condition	0.48049750
94	MP0005584_abnormal_enzyme/coenzyme_acti	0.47736814
95	MP0009642_abnormal_blood_homeostasis	0.46446466
96	MP0003011_delayed_dark_adaptation	0.45340478
97	MP0005551_abnormal_eye_electrophysiolog	0.45304778
98	MP0005319_abnormal_enzyme/_coenzyme	0.44323366
99	MP0001958_emphysema	0.44181138
100	MP0001765_abnormal_ion_homeostasis	0.43520648

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgM level (HP:0003496)	7.35369391
2	Abnormality of T cell number (HP:0011839)	6.08209342
3	Abnormal delayed hypersensitivity skin test (HP:0002963)	5.55121395
4	T lymphocytopenia (HP:0005403)	5.08486726
5	Optic neuritis (HP:0100653)	5.06371269
6	Retrobulbar optic neuritis (HP:0100654)	5.06371269
7	Myositis (HP:0100614)	5.04576156
8	IgG deficiency (HP:0004315)	4.88101524
9	Encephalitis (HP:0002383)	4.87253549
10	Orchitis (HP:0100796)	4.65445563
11	Eosinophilia (HP:0001880)	4.52447814
12	Joint swelling (HP:0001386)	4.37724823
13	3-Methylglutaconic aciduria (HP:0003535)	4.37115389
14	Abnormality of T cells (HP:0002843)	4.12053082
15	Granulocytopenia (HP:0001913)	4.10770124
16	Abnormality of eosinophils (HP:0001879)	3.99415520
17	Visual hallucinations (HP:0002367)	3.85984304
18	Autoimmune thrombocytopenia (HP:0001973)	3.85042370
19	Hemoptysis (HP:0002105)	3.77578086
20	Autoimmune hemolytic anemia (HP:0001890)	3.70725630
21	Abnormality of T cell physiology (HP:0011840)	3.42857282
22	Meningitis (HP:0001287)	3.37888324
23	Keratoconjunctivitis sicca (HP:0001097)	3.37207427
24	Vasculitis (HP:0002633)	3.22886234
25	Leukocytosis (HP:0001974)	3.12500630
26	Recurrent fungal infections (HP:0002841)	3.08617818
27	Keratoconjunctivitis (HP:0001096)	3.06483565
28	Pulmonary infiltrates (HP:0002113)	3.00937320
29	Hypoproteinemia (HP:0003075)	2.95261029
30	Carpal bone hypoplasia (HP:0001498)	2.95188946
31	Abnormality of macrophages (HP:0004311)	2.93394521
32	Tongue fasciculations (HP:0001308)	2.87906482
33	Hemiplegia (HP:0002301)	2.85755655
34	Fatigue (HP:0012378)	2.85689367
35	Hypochromic anemia (HP:0001931)	2.84509326
36	Recurrent bacterial skin infections (HP:0005406)	2.83726536
37	Chronic diarrhea (HP:0002028)	2.80890338
38	Gangrene (HP:0100758)	2.78524404
39	Hypergammaglobulinemia (HP:0010702)	2.76158804
40	Muscle fibrillation (HP:0010546)	2.74908152
41	Keratitis (HP:0000491)	2.62900940
42	Broad alveolar ridges (HP:0000187)	2.62368844
43	Pulmonary embolism (HP:0002204)	2.57749541
44	Pustule (HP:0200039)	2.56643542
45	Glomerulopathy (HP:0100820)	2.55950975
46	Recurrent abscess formation (HP:0002722)	2.47807731
47	Supernumerary ribs (HP:0005815)	2.47491194
48	Anorexia (HP:0002039)	2.44252568
49	Dyschromatopsia (HP:0007641)	2.41594166
50	Obstructive lung disease (HP:0006536)	2.40921753
51	Chronic obstructive pulmonary disease (HP:0006510)	2.40921753
52	Spondylolisthesis (HP:0003302)	2.38008220
53	Arterial thrombosis (HP:0004420)	2.34912856
54	Abnormality of the prostate (HP:0008775)	2.33218562
55	Severe combined immunodeficiency (HP:0004430)	2.31934863
56	Cheilitis (HP:0100825)	2.31336515
57	Stomatitis (HP:0010280)	2.29526492
58	Supernumerary bones of the axial skeleton (HP:0009144)	2.27210629
59	Growth hormone excess (HP:0000845)	2.26828678
60	Abnormality of the aortic arch (HP:0012303)	2.25976802
61	Elevated erythrocyte sedimentation rate (HP:0003565)	2.21818110
62	Recurrent skin infections (HP:0001581)	2.19076535
63	Hypoalbuminemia (HP:0003073)	2.15650482
64	Abnormal albumin level (HP:0012116)	2.15650482
65	Abnormal biliary tract physiology (HP:0012439)	2.13764961
66	Bile duct proliferation (HP:0001408)	2.13764961
67	Acute hepatic failure (HP:0006554)	2.12794294
68	Recurrent cutaneous fungal infections (HP:0011370)	2.11543809
69	Chronic mucocutaneous candidiasis (HP:0002728)	2.11543809
70	Conical tooth (HP:0000698)	2.11127331
71	Abnormality of the endocardium (HP:0004306)	2.11108453
72	Premature skin wrinkling (HP:0100678)	2.10661398
73	Recurrent bronchitis (HP:0002837)	2.09470059
74	Abnormality of the pleura (HP:0002103)	2.09357397
75	Corneal dystrophy (HP:0001131)	2.08193191
76	Panhypogammaglobulinemia (HP:0003139)	2.07287660
77	Pancreatitis (HP:0001733)	2.07272530
78	Amyotrophic lateral sclerosis (HP:0007354)	2.05684931
79	Pulmonary fibrosis (HP:0002206)	2.04177546
80	Facial diplegia (HP:0001349)	2.03989988
81	IgA deficiency (HP:0002720)	2.03432630
82	Abnormality of dentin (HP:0010299)	2.00110871
83	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.99420484
84	Recurrent viral infections (HP:0004429)	1.98145314
85	Gaze-evoked nystagmus (HP:0000640)	1.96932367
86	Agammaglobulinemia (HP:0004432)	1.95860253
87	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95448634
88	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95448634
89	Skin rash (HP:0000988)	1.94926182
90	Keratoconus (HP:0000563)	1.90165446
91	Increased corneal curvature (HP:0100692)	1.90165446
92	Retinopathy (HP:0000488)	1.89314688
93	Polyneuropathy (HP:0001271)	1.87423920
94	Chest pain (HP:0100749)	1.85704945
95	Acne (HP:0001061)	1.84842070
96	Congenital hip dislocation (HP:0001374)	1.84546670
97	Focal motor seizures (HP:0011153)	1.84503359
98	Pancreatic cysts (HP:0001737)	1.83861755
99	Thick nail (HP:0001805)	1.82742852
100	Prolonged bleeding time (HP:0003010)	1.82205339

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	7.35853655
2	SIK2	6.13366547
3	MAP2K6	3.70749118
4	TBK1	3.17706320
5	GRK6	2.98834626
6	BCR	2.78224792
7	NEK2	2.71446187
8	ACVR1B	2.71329579
9	MAP3K14	2.55549511
10	NUAK1	2.44621213
11	JAK3	2.16672395
12	MAP4K1	2.13952236
13	BRD4	2.10724768
14	FES	2.09917142
15	IKBKB	1.91796642
16	KDR	1.87173691
17	TLK1	1.73317230
18	IKBKE	1.72579954
19	CSK	1.70441212
20	PRKCQ	1.64693809
21	ZAP70	1.53117125
22	TNK2	1.48856315
23	RAF1	1.45029971
24	ITK	1.42398430
25	TEC	1.37932584
26	CSF1R	1.35320506
27	BTK	1.35291394
28	TAOK3	1.31807861
29	LCK	1.27955438
30	SYK	1.23865498
31	MAP3K13	1.19589762
32	SIK3	1.09212954
33	MAPKAPK3	1.06060481
34	BLK	0.96741533
35	DMPK	0.90645573
36	IRAK4	0.86965996
37	ADRBK2	0.86657389
38	LYN	0.84611056
39	CHUK	0.83301736
40	MATK	0.81054597
41	SRPK1	0.77620956
42	MAP2K2	0.75781449
43	EIF2AK2	0.75662634
44	HCK	0.72863490
45	STK10	0.72065005
46	FGR	0.71490738
47	MAPK7	0.70262070
48	RIPK4	0.66163425
49	EIF2AK3	0.65381874
50	JAK1	0.59589303
51	JAK2	0.59386361
52	BCKDK	0.58673199
53	TESK2	0.56334276
54	MARK3	0.56247346
55	FRK	0.55854062
56	TRIM28	0.54838319
57	FYN	0.52549271
58	CDK3	0.50513024
59	STK24	0.49439921
60	PIM1	0.48821355
61	KIT	0.47886002
62	MAPK13	0.47087358
63	MAPK11	0.43967138
64	TYRO3	0.43905695
65	GRK7	0.39777496
66	ROCK1	0.37470371
67	PRKCI	0.33651568
68	MAP3K11	0.33351971
69	NTRK1	0.32096284
70	IGF1R	0.31041755
71	CDK19	0.30123993
72	PIK3CG	0.29703783
73	RPS6KA5	0.29174776
74	PRKCD	0.26930259
75	MAPKAPK2	0.26837158
76	PDGFRB	0.26198974
77	KSR1	0.25976101
78	INSR	0.25243461
79	ILK	0.25132957
80	PTK2B	0.24592575
81	PDK1	0.24237886
82	PRKCH	0.23894212
83	PHKG2	0.23886152
84	PHKG1	0.23886152
85	CAMKK2	0.23501090
86	GRK1	0.23364975
87	CSNK1D	0.23061106
88	ABL1	0.22937398
89	RPS6KA6	0.22279056
90	CDK4	0.20758809
91	MAP3K7	0.19661406
92	MAPK3	0.19493607
93	DAPK2	0.19486724
94	MAP3K4	0.18658664
95	NTRK3	0.18397939
96	MAP3K2	0.17438077
97	ERBB2	0.17004132
98	MAPK12	0.16569944
99	PKN1	0.16362629
100	CDK12	0.16295119

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Graft-versus-host disease_Homo sapiens_hsa05332	5.46194039
2	Allograft rejection_Homo sapiens_hsa05330	4.04227827
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.93959331
4	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	3.74717917
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.68852633
6	Antigen processing and presentation_Homo sapiens_hsa04612	3.59602967
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.52324349
8	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.29127897
9	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.23578833
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.15997672
11	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.15648395
12	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.04139869
13	Measles_Homo sapiens_hsa05162	1.99810955
14	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.95575890
15	Leishmaniasis_Homo sapiens_hsa05140	1.94726288
16	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.89872726
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.79242004
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.65614204
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.65596338
20	African trypanosomiasis_Homo sapiens_hsa05143	1.57624399
21	Herpes simplex infection_Homo sapiens_hsa05168	1.52734528
22	Viral myocarditis_Homo sapiens_hsa05416	1.51090690
23	Asthma_Homo sapiens_hsa05310	1.45841622
24	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.43218982
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.36100458
26	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.34989309
27	Osteoclast differentiation_Homo sapiens_hsa04380	1.33534482
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.26622580
29	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.26342176
30	TNF signaling pathway_Homo sapiens_hsa04668	1.26037125
31	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.25632545
32	Chemokine signaling pathway_Homo sapiens_hsa04062	1.23986729
33	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.14077056
34	Apoptosis_Homo sapiens_hsa04210	1.07859459
35	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.07758564
36	Influenza A_Homo sapiens_hsa05164	1.07265007
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.05190406
38	Hepatitis B_Homo sapiens_hsa05161	1.02393276
39	Malaria_Homo sapiens_hsa05144	1.01516217
40	Shigellosis_Homo sapiens_hsa05131	0.98355671
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94763345
42	Legionellosis_Homo sapiens_hsa05134	0.81893691
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78369356
44	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.77269431
45	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.76660937
46	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.74892984
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70304111
48	Toxoplasmosis_Homo sapiens_hsa05145	0.69399314
49	Prion diseases_Homo sapiens_hsa05020	0.65950088
50	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.63507001
51	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.59875898
52	Regulation of autophagy_Homo sapiens_hsa04140	0.59785067
53	Platelet activation_Homo sapiens_hsa04611	0.56368942
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.55445346
55	Tuberculosis_Homo sapiens_hsa05152	0.54535140
56	Hepatitis C_Homo sapiens_hsa05160	0.52722797
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52592296
58	Pertussis_Homo sapiens_hsa05133	0.51121974
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49273701
60	Caffeine metabolism_Homo sapiens_hsa00232	0.46469177
61	Salmonella infection_Homo sapiens_hsa05132	0.46019238
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.44419607
63	Viral carcinogenesis_Homo sapiens_hsa05203	0.38218073
64	Phototransduction_Homo sapiens_hsa04744	0.37898805
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.36784189
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34409508
67	Lysosome_Homo sapiens_hsa04142	0.32507099
68	HTLV-I infection_Homo sapiens_hsa05166	0.30534246
69	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.30297136
70	Acute myeloid leukemia_Homo sapiens_hsa05221	0.30034412
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.29762139
72	Phagosome_Homo sapiens_hsa04145	0.29220827
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.28273048
74	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.25082422
75	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.24729695
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.24492046
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22326484
78	RNA degradation_Homo sapiens_hsa03018	0.20009422
79	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.19571263
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18208119
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.17595231
82	Endocytosis_Homo sapiens_hsa04144	0.16305562
83	Morphine addiction_Homo sapiens_hsa05032	0.15628713
84	Salivary secretion_Homo sapiens_hsa04970	0.15117109
85	Prolactin signaling pathway_Homo sapiens_hsa04917	0.14761205
86	Pancreatic cancer_Homo sapiens_hsa05212	0.14533537
87	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.13477428
88	mTOR signaling pathway_Homo sapiens_hsa04150	0.13373794
89	Non-small cell lung cancer_Homo sapiens_hsa05223	0.12425839
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.12288596
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.11778476
92	Insulin resistance_Homo sapiens_hsa04931	0.10081189
93	Retinol metabolism_Homo sapiens_hsa00830	0.09884820
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.09075195
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.09054869
96	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.08982199
97	ABC transporters_Homo sapiens_hsa02010	0.08817655
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.08441963
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.06435922
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.06261028

HMGB3P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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