HMGB3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)8.97246749
2diterpenoid biosynthetic process (GO:0016102)7.31363696
3negative regulation of cAMP-mediated signaling (GO:0043951)6.86392652
4embryonic camera-type eye development (GO:0031076)6.72600514
5indole-containing compound catabolic process (GO:0042436)6.29606221
6indolalkylamine catabolic process (GO:0046218)6.29606221
7tryptophan catabolic process (GO:0006569)6.29606221
8regulation of inclusion body assembly (GO:0090083)5.82156111
9kynurenine metabolic process (GO:0070189)5.58858466
10terpenoid biosynthetic process (GO:0016114)5.40654239
11hypotonic response (GO:0006971)5.15582711
12DNA replication initiation (GO:0006270)5.15490156
13tryptophan metabolic process (GO:0006568)5.10452580
14acrosome reaction (GO:0007340)5.03970984
15alternative mRNA splicing, via spliceosome (GO:0000380)4.97527507
16protein K11-linked deubiquitination (GO:0035871)4.93826853
17histone H3-K4 trimethylation (GO:0080182)4.88766145
18mammary gland epithelial cell proliferation (GO:0033598)4.82139992
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.69375817
20phosphorelay signal transduction system (GO:0000160)4.66227189
21ganglion development (GO:0061548)4.64573039
22phosphatidylethanolamine biosynthetic process (GO:0006646)4.57268940
23negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.49736629
24macroautophagy (GO:0016236)4.44252330
25negative regulation of potassium ion transmembrane transport (GO:1901380)4.24073879
26phosphatidylethanolamine metabolic process (GO:0046337)4.09997856
27cAMP catabolic process (GO:0006198)4.07728826
28histone mRNA catabolic process (GO:0071044)4.02554342
29cellular response to ethanol (GO:0071361)4.01675152
30retinal metabolic process (GO:0042574)3.86609667
31positive regulation of circadian rhythm (GO:0042753)3.82809308
32aromatic amino acid family catabolic process (GO:0009074)3.80353012
33regulation of timing of cell differentiation (GO:0048505)3.78144927
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77800930
35negative regulation of viral release from host cell (GO:1902187)3.72147587
36phenylpropanoid metabolic process (GO:0009698)3.71082945
37amine catabolic process (GO:0009310)3.66059653
38cellular biogenic amine catabolic process (GO:0042402)3.66059653
39retina layer formation (GO:0010842)3.62182939
40positive regulation of T cell differentiation in thymus (GO:0033089)3.57892852
41positive regulation of chondrocyte differentiation (GO:0032332)3.53956139
42SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.52745721
43cyclic nucleotide catabolic process (GO:0009214)3.46474970
44indolalkylamine metabolic process (GO:0006586)3.44978918
45embryonic viscerocranium morphogenesis (GO:0048703)3.40678577
46DNA strand elongation involved in DNA replication (GO:0006271)3.38984287
47negative regulation of viral entry into host cell (GO:0046597)3.38138846
48negative regulation of lipid storage (GO:0010888)3.32137231
49benzene-containing compound metabolic process (GO:0042537)3.29594754
50organ formation (GO:0048645)3.29438226
51ear development (GO:0043583)3.26373665
52positive regulation of cAMP-mediated signaling (GO:0043950)3.26332231
53N-glycan processing (GO:0006491)3.24117125
54opsonization (GO:0008228)3.18989094
55negative regulation of epidermal cell differentiation (GO:0045605)3.18062518
56negative regulation of smoothened signaling pathway (GO:0045879)3.14726434
57phosphatidylcholine biosynthetic process (GO:0006656)3.13560400
58regulation of acrosome reaction (GO:0060046)3.12722626
59peptidyl-lysine trimethylation (GO:0018023)3.11205168
60regulation of B cell receptor signaling pathway (GO:0050855)3.09801501
61regulation of cilium movement (GO:0003352)3.09279300
62DNA strand elongation (GO:0022616)3.06666289
63negative regulation of microtubule depolymerization (GO:0007026)3.00970843
64regulation of development, heterochronic (GO:0040034)2.98692428
65adenosine metabolic process (GO:0046085)2.97447580
66interleukin-6-mediated signaling pathway (GO:0070102)2.91454298
67L-ascorbic acid metabolic process (GO:0019852)2.90103455
68morphogenesis of an epithelial fold (GO:0060571)2.89358981
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.87544076
70lysine catabolic process (GO:0006554)2.84566122
71lysine metabolic process (GO:0006553)2.84566122
72ovulation from ovarian follicle (GO:0001542)2.84333517
73mitotic sister chromatid segregation (GO:0000070)2.84075676
74otic vesicle formation (GO:0030916)2.82821264
75negative regulation of potassium ion transport (GO:0043267)2.80545908
76male sex determination (GO:0030238)2.74040231
77branch elongation of an epithelium (GO:0060602)2.72654092
78Golgi to endosome transport (GO:0006895)2.71952235
79protein destabilization (GO:0031648)2.71586962
80peptidyl-lysine methylation (GO:0018022)2.70425327
81regulation of viral entry into host cell (GO:0046596)2.65913752
82glucocorticoid receptor signaling pathway (GO:0042921)2.65733193
83response to lead ion (GO:0010288)2.65121833
84regulation of microtubule depolymerization (GO:0031114)2.64150891
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63249951
86heparin metabolic process (GO:0030202)2.62317391
87heparin biosynthetic process (GO:0030210)2.62317391
88positive regulation of histone H3-K4 methylation (GO:0051571)2.62150331
89positive regulation of glomerulus development (GO:0090193)2.60038788
90histone lysine methylation (GO:0034968)2.58392624
91sex determination (GO:0007530)2.57487550
92Sertoli cell development (GO:0060009)2.57206163
93oligodendrocyte differentiation (GO:0048709)2.56846256
94cerebral cortex radially oriented cell migration (GO:0021799)2.56772015
95regulation of microtubule-based movement (GO:0060632)2.55466979
96negative regulation of endothelial cell migration (GO:0010596)2.54068420
97positive regulation of granulocyte differentiation (GO:0030854)2.52268721
98positive regulation of response to oxidative stress (GO:1902884)2.52210414
99positive regulation of cellular response to oxidative stress (GO:1900409)2.52210414
100heart process (GO:0003015)2.51764444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human7.33504837
2E2F7_22180533_ChIP-Seq_HELA_Human6.82334072
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.18727619
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.19882370
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11232950
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97856062
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83412721
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.76536662
9PCGF2_27294783_Chip-Seq_NPCs_Mouse2.36866476
10SCL_19346495_ChIP-Seq_HPC-7_Human2.32916118
11RUNX_20019798_ChIP-Seq_JUKART_Human2.27869987
12ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.09322527
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07376152
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93826987
15VDR_22108803_ChIP-Seq_LS180_Human1.92806840
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88340738
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83305485
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.81585617
19NFE2_27457419_Chip-Seq_LIVER_Mouse1.66135785
20GATA1_22025678_ChIP-Seq_K562_Human1.63335269
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58149716
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52253005
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51570642
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.49724445
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49461201
26FUS_26573619_Chip-Seq_HEK293_Human1.45426059
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43567747
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33103131
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.31750679
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30824798
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30153434
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30080303
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29754577
34IGF1R_20145208_ChIP-Seq_DFB_Human1.26963794
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.26449367
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.26369777
37AHR_22903824_ChIP-Seq_MCF-7_Human1.26356530
38CIITA_25753668_ChIP-Seq_RAJI_Human1.23678057
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22521291
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21710681
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.21194610
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21027994
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19526114
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.18673124
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18226891
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18123031
47E2F1_18555785_Chip-Seq_ESCs_Mouse1.17753825
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17532543
49P53_22387025_ChIP-Seq_ESCs_Mouse1.17129858
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.16901783
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16805077
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16805077
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16402633
54KDM2B_26808549_Chip-Seq_REH_Human1.16342358
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14590829
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.12717537
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.12031925
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.07954765
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07588763
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07272461
61CTCF_18555785_Chip-Seq_ESCs_Mouse1.06916618
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06584889
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04960770
64STAT3_23295773_ChIP-Seq_U87_Human1.04628207
65SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03987252
66MYB_26560356_Chip-Seq_TH2_Human1.03526463
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.03390997
68TCF4_23295773_ChIP-Seq_U87_Human1.01321079
69CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99942862
70OCT1_27270436_Chip-Seq_PROSTATE_Human0.98381002
71OCT4_18555785_Chip-Seq_ESCs_Mouse0.98131676
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97760330
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97463676
74STAT3_18555785_Chip-Seq_ESCs_Mouse0.97432761
75SMAD4_21799915_ChIP-Seq_A2780_Human0.95880363
76ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95758063
77GATA3_27048872_Chip-Seq_THYMUS_Human0.95515302
78SMRT_27268052_Chip-Seq_Bcells_Human0.95283359
79P300_19829295_ChIP-Seq_ESCs_Human0.95239087
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94491195
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94243387
82TBL1_22424771_ChIP-Seq_293T_Human0.93986306
83FOXA2_19822575_ChIP-Seq_HepG2_Human0.92895142
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92888641
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92374778
86P300_18555785_Chip-Seq_ESCs_Mouse0.91935154
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.91861982
88AR_25329375_ChIP-Seq_VCAP_Human0.91392851
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90973919
90TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90730519
91AR_21572438_ChIP-Seq_LNCaP_Human0.90658524
92KLF4_18555785_Chip-Seq_ESCs_Mouse0.90477734
93TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89969163
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89131665
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88486378
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.87819352
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86939894
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.86479906
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86131707
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84797843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.47047862
2MP0003172_abnormal_lysosome_physiology4.43660839
3MP0000569_abnormal_digit_pigmentation3.95279727
4MP0008260_abnormal_autophagy3.54507248
5MP0006035_abnormal_mitochondrial_morpho3.36111764
6MP0003656_abnormal_erythrocyte_physiolo3.13449263
7MP0003183_abnormal_peptide_metabolism2.96108698
8MP0002876_abnormal_thyroid_physiology2.73122406
9MP0003763_abnormal_thymus_physiology2.16431019
10MP0001873_stomach_inflammation2.15664627
11MP0003724_increased_susceptibility_to2.06129635
12MP0001545_abnormal_hematopoietic_system1.97846318
13MP0005397_hematopoietic_system_phenotyp1.97846318
14MP0005379_endocrine/exocrine_gland_phen1.91249861
15MP0000358_abnormal_cell_content/1.86541696
16MP0008877_abnormal_DNA_methylation1.75429164
17MP0010094_abnormal_chromosome_stability1.72187376
18MP0004215_abnormal_myocardial_fiber1.71000757
19MP0002405_respiratory_system_inflammati1.70085275
20MP0002971_abnormal_brown_adipose1.62320449
21MP0010386_abnormal_urinary_bladder1.60292961
22MP0006054_spinal_hemorrhage1.54708748
23MP0005310_abnormal_salivary_gland1.52287728
24MP0001958_emphysema1.48945542
25MP0003646_muscle_fatigue1.47815026
26MP0001800_abnormal_humoral_immune1.47024083
27MP0002163_abnormal_gland_morphology1.45312861
28MP0004147_increased_porphyrin_level1.42708314
29MP0002254_reproductive_system_inflammat1.32314130
30MP0008057_abnormal_DNA_replication1.29696535
31MP0003943_abnormal_hepatobiliary_system1.28211269
32MP0000749_muscle_degeneration1.26513850
33MP0003787_abnormal_imprinting1.26418469
34MP0003121_genomic_imprinting1.25857419
35MP0005666_abnormal_adipose_tissue1.25757861
36MP0000015_abnormal_ear_pigmentation1.25118276
37MP0001440_abnormal_grooming_behavior1.23949323
38MP0001835_abnormal_antigen_presentation1.17467421
39MP0001485_abnormal_pinna_reflex1.16155085
40MP0002723_abnormal_immune_serum1.14222054
41MP0003111_abnormal_nucleus_morphology1.12567188
42MP0000465_gastrointestinal_hemorrhage1.12251372
43MP0001270_distended_abdomen1.11746956
44MP0002638_abnormal_pupillary_reflex1.09620855
45MP0006082_CNS_inflammation1.06759200
46MP0002970_abnormal_white_adipose1.06181403
47MP0005375_adipose_tissue_phenotype1.05952828
48MP0005410_abnormal_fertilization1.05145337
49MP0001915_intracranial_hemorrhage1.02486517
50MP0002452_abnormal_antigen_presenting0.98038998
51MP0009764_decreased_sensitivity_to0.97352114
52MP0002933_joint_inflammation0.96103587
53MP0002138_abnormal_hepatobiliary_system0.96041186
54MP0004043_abnormal_pH_regulation0.95537268
55MP0006072_abnormal_retinal_apoptosis0.90829943
56MP0005220_abnormal_exocrine_pancreas0.89723156
57MP0008961_abnormal_basal_metabolism0.88568784
58MP0009046_muscle_twitch0.87103837
59MP0005387_immune_system_phenotype0.84082582
60MP0001790_abnormal_immune_system0.84082582
61MP0002419_abnormal_innate_immunity0.83990175
62MP0003123_paternal_imprinting0.83698795
63MP0001944_abnormal_pancreas_morphology0.83293659
64MP0009785_altered_susceptibility_to0.82459509
65MP0004742_abnormal_vestibular_system0.82117948
66MP0008058_abnormal_DNA_repair0.82108086
67MP0005164_abnormal_response_to0.82048380
68MP0000003_abnormal_adipose_tissue0.81397659
69MP0002396_abnormal_hematopoietic_system0.81186285
70MP0002420_abnormal_adaptive_immunity0.80828815
71MP0004484_altered_response_of0.80720704
72MP0004947_skin_inflammation0.79553285
73MP0005319_abnormal_enzyme/_coenzyme0.78396424
74MP0001819_abnormal_immune_cell0.78286913
75MP0001784_abnormal_fluid_regulation0.77587331
76MP0001986_abnormal_taste_sensitivity0.77520845
77MP0000716_abnormal_immune_system0.76955129
78MP0005076_abnormal_cell_differentiation0.76648835
79MP0000566_synostosis0.75426085
80MP0002398_abnormal_bone_marrow0.74528968
81MP0005000_abnormal_immune_tolerance0.74173720
82MP0003136_yellow_coat_color0.73976015
83MP0000689_abnormal_spleen_morphology0.72208490
84MP0003186_abnormal_redox_activity0.71340882
85MP0005595_abnormal_vascular_smooth0.70661884
86MP0008872_abnormal_physiological_respon0.69711755
87MP0002429_abnormal_blood_cell0.67821829
88MP0002928_abnormal_bile_duct0.67132141
89MP0001851_eye_inflammation0.66946768
90MP0004381_abnormal_hair_follicle0.66053121
91MP0000470_abnormal_stomach_morphology0.65103167
92MP0010329_abnormal_lipoprotein_level0.65015712
93MP0008469_abnormal_protein_level0.63699735
94MP0002078_abnormal_glucose_homeostasis0.63141374
95MP0002722_abnormal_immune_system0.62349102
96MP0005671_abnormal_response_to0.62211751
97MP0002277_abnormal_respiratory_mucosa0.61909480
98MP0006138_congestive_heart_failure0.61614206
99MP0000703_abnormal_thymus_morphology0.61574585
100MP0001501_abnormal_sleep_pattern0.60857143

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)6.71882965
2Abnormality of the fingertips (HP:0001211)5.99162831
3Diastasis recti (HP:0001540)5.30418316
4Morphological abnormality of the inner ear (HP:0011390)4.97079878
5Absent hand (HP:0004050)4.71797209
6Abnormality of lateral ventricle (HP:0030047)4.71288921
7Deep palmar crease (HP:0006191)4.63709684
8Conical tooth (HP:0000698)4.61672153
9Flat capital femoral epiphysis (HP:0003370)4.59997284
10Hypoplastic iliac wings (HP:0002866)4.53253184
11Chin dimple (HP:0010751)4.31292426
12Acute myeloid leukemia (HP:0004808)3.88714081
13Poor speech (HP:0002465)3.49942465
14Calcaneovalgus deformity (HP:0001848)3.46375048
15Facial cleft (HP:0002006)3.32056640
16Tracheomalacia (HP:0002779)3.15385531
17Carpal bone hypoplasia (HP:0001498)3.12644812
18Congenital sensorineural hearing impairment (HP:0008527)3.08391854
19Overlapping toe (HP:0001845)3.08071420
20Absent septum pellucidum (HP:0001331)3.05222492
21Abnormality of the labia minora (HP:0012880)3.03638319
22Abnormality of the proximal phalanges of the hand (HP:0009834)3.03108274
23Deformed tarsal bones (HP:0008119)3.02843726
24Abnormality of the calcaneus (HP:0008364)3.00869212
2511 pairs of ribs (HP:0000878)2.94627252
26Acanthocytosis (HP:0001927)2.92137262
27Stomach cancer (HP:0012126)2.88607328
28Nephronophthisis (HP:0000090)2.79727960
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77824378
30Chronic otitis media (HP:0000389)2.72464873
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70956505
32Abnormality of the septum pellucidum (HP:0007375)2.70452598
33Ketoacidosis (HP:0001993)2.66079159
34Progressive inability to walk (HP:0002505)2.64869503
35Abnormality of the wing of the ilium (HP:0011867)2.58145598
36Flared metaphyses (HP:0003015)2.57223800
37Increased density of long bones (HP:0006392)2.51952363
38Small epiphyses (HP:0010585)2.49218943
39Thick nail (HP:0001805)2.46658399
40Abnormality of incisor morphology (HP:0011063)2.46226850
41Molar tooth sign on MRI (HP:0002419)2.41701855
42Abnormality of midbrain morphology (HP:0002418)2.41701855
43Sandal gap (HP:0001852)2.35392058
44Chromsome breakage (HP:0040012)2.34362331
45Abnormal sex determination (HP:0012244)2.34186686
46Sex reversal (HP:0012245)2.34186686
47Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.33868412
48Short 1st metacarpal (HP:0010034)2.33868412
49Abnormality of the renal medulla (HP:0100957)2.27767553
50Abnormality of dental color (HP:0011073)2.27008411
51Hyperglycinuria (HP:0003108)2.26331650
52Broad distal phalanx of finger (HP:0009836)2.24864604
53Limited elbow extension (HP:0001377)2.22626043
54Dyskinesia (HP:0100660)2.20764724
55Broad-based gait (HP:0002136)2.19465789
56Drooling (HP:0002307)2.13840759
57Hypoplastic ilia (HP:0000946)2.08528675
58Spondylolisthesis (HP:0003302)2.06929895
59Vertebral arch anomaly (HP:0008438)2.05388061
60Progressive hearing impairment (HP:0001730)2.04531804
61Excessive salivation (HP:0003781)2.03395753
62Bronchomalacia (HP:0002780)2.01283352
63Gaze-evoked nystagmus (HP:0000640)2.00416849
64Pancreatic cysts (HP:0001737)1.98274222
65Tetraparesis (HP:0002273)1.98071401
66Abnormality of the 1st metacarpal (HP:0010009)1.98011690
67Deep philtrum (HP:0002002)1.96277358
68Pustule (HP:0200039)1.91317816
69Hypoplastic nipples (HP:0002557)1.88465203
70Eosinophilia (HP:0001880)1.85992718
71Anhidrosis (HP:0000970)1.85178667
72Febrile seizures (HP:0002373)1.85094135
73Insulin-resistant diabetes mellitus (HP:0000831)1.82275109
74Abnormality of the labia majora (HP:0012881)1.78886551
75Ketosis (HP:0001946)1.76965664
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76938490
77Erythema (HP:0010783)1.76577026
78Broad phalanges of the hand (HP:0009768)1.75137694
79Alacrima (HP:0000522)1.73902841
80Exocrine pancreatic insufficiency (HP:0001738)1.73783766
81Facial hemangioma (HP:0000329)1.72502073
82Recurrent bronchitis (HP:0002837)1.71658964
83True hermaphroditism (HP:0010459)1.71397246
84Abnormality of eosinophils (HP:0001879)1.70456449
85Tented upper lip vermilion (HP:0010804)1.69984212
86Inappropriate behavior (HP:0000719)1.69583850
87Disinhibition (HP:0000734)1.68970906
88Hypoplastic labia majora (HP:0000059)1.68713663
89Supernumerary bones of the axial skeleton (HP:0009144)1.68547680
90Coxa valga (HP:0002673)1.67803337
91Broad thumb (HP:0011304)1.65494658
92Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63600457
93Hematochezia (HP:0002573)1.61981520
94Patellar aplasia (HP:0006443)1.61616025
95Granulocytopenia (HP:0001913)1.61264473
96Optic nerve hypoplasia (HP:0000609)1.59854831
97Gowers sign (HP:0003391)1.57281238
98Thickened nuchal skin fold (HP:0000474)1.55379174
99Broad phalanx (HP:0006009)1.54596499
100Supernumerary ribs (HP:0005815)1.53716515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L9.56747629
2BLK5.14151309
3STK384.84818172
4WNK13.84798765
5FRK2.53282418
6MAP3K142.29701545
7STK392.10732782
8BRSK22.03178402
9ZAP701.99167645
10MAP3K131.64864112
11IKBKE1.59327565
12CDC71.53739794
13IKBKB1.52634084
14ACVR1B1.38366032
15BMPR1B1.35108948
16NLK1.31569072
17FGFR21.30420723
18LMTK21.25392806
19EIF2AK11.20831026
20STK41.20116400
21BMPR21.18246803
22MARK31.17428733
23PTK2B1.10621427
24SGK21.03858594
25MARK21.03796704
26FES0.99107228
27PAK30.96969097
28WNK40.94453232
29OXSR10.92180370
30TXK0.89444165
31LYN0.86426605
32GRK10.82064025
33SGK30.82058133
34TAOK30.81181709
35PINK10.80553663
36TEC0.80456152
37PRKG20.78867407
38SYK0.76865879
39ITK0.76792342
40CSNK1D0.75747655
41MAP2K30.73593999
42CHUK0.72624329
43PRKAA20.70100431
44RIPK10.69944018
45PIK3CG0.67256512
46CDK40.58161620
47TNIK0.56991674
48INSRR0.56912575
49LCK0.56834155
50JAK20.54704328
51MAP2K60.54090479
52DMPK0.53280250
53STK100.52710333
54MAP2K10.52217029
55BRD40.51865081
56PLK20.51049861
57KSR20.50144756
58MAPK130.48915087
59PAK60.48903413
60JAK10.48019056
61ROCK10.47240122
62KIT0.46334621
63SGK4940.46029478
64SGK2230.46029478
65TBK10.45495501
66FGFR30.45394253
67EPHA20.44834857
68EGFR0.43589763
69RAF10.41767366
70GRK60.40077102
71PNCK0.39865113
72PRKCQ0.38937318
73GRK50.37554734
74CDK190.34009217
75BRSK10.33486143
76MAP3K70.33164635
77JAK30.32827433
78PRKD20.32129117
79MAPK90.30367669
80MAPK30.29828625
81PRKG10.29771186
82MAPK110.29718809
83FGFR10.29236697
84MTOR0.27854133
85PRKCE0.27819304
86ERBB20.27814866
87MAPK80.27299469
88PRKAA10.26442618
89CSNK1G10.25601418
90MAPK140.25476250
91CDK30.25421846
92CASK0.24911481
93ATM0.23871002
94DAPK20.23506553
95CSK0.23505564
96ABL10.23203228
97PRKACB0.23079492
98GSK3B0.22437730
99MAP3K60.22061707
100CAMK1G0.21944876

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.50789755
2Sulfur metabolism_Homo sapiens_hsa009202.84372882
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.74312827
4Lysine degradation_Homo sapiens_hsa003102.47674888
5DNA replication_Homo sapiens_hsa030302.45051532
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.32378767
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.29300660
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.17509325
9Tryptophan metabolism_Homo sapiens_hsa003802.10166748
10Non-homologous end-joining_Homo sapiens_hsa034502.05478014
11B cell receptor signaling pathway_Homo sapiens_hsa046622.04026850
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95624720
13Shigellosis_Homo sapiens_hsa051311.95607349
14Phototransduction_Homo sapiens_hsa047441.85620914
15Regulation of autophagy_Homo sapiens_hsa041401.72328569
16ABC transporters_Homo sapiens_hsa020101.70602690
17Primary immunodeficiency_Homo sapiens_hsa053401.70600462
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.57242019
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.49517288
20T cell receptor signaling pathway_Homo sapiens_hsa046601.45803818
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44047811
22Glycerolipid metabolism_Homo sapiens_hsa005611.38920678
23Nitrogen metabolism_Homo sapiens_hsa009101.38847289
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.34051951
25Hedgehog signaling pathway_Homo sapiens_hsa043401.32502252
26TNF signaling pathway_Homo sapiens_hsa046681.28698039
27Malaria_Homo sapiens_hsa051441.28227916
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25007279
29Morphine addiction_Homo sapiens_hsa050321.22132094
30Osteoclast differentiation_Homo sapiens_hsa043801.19267656
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14910130
32Retinol metabolism_Homo sapiens_hsa008301.13139061
33Chemokine signaling pathway_Homo sapiens_hsa040621.10743840
34Arachidonic acid metabolism_Homo sapiens_hsa005901.10377264
35Starch and sucrose metabolism_Homo sapiens_hsa005001.08477121
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04421091
37Protein export_Homo sapiens_hsa030601.00851438
38Renin-angiotensin system_Homo sapiens_hsa046140.97639416
39Small cell lung cancer_Homo sapiens_hsa052220.95922548
40Fanconi anemia pathway_Homo sapiens_hsa034600.95068132
41Acute myeloid leukemia_Homo sapiens_hsa052210.91889063
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90488693
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90070517
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.89068744
45Proteasome_Homo sapiens_hsa030500.87064069
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84994941
47Choline metabolism in cancer_Homo sapiens_hsa052310.84145694
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79806268
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78368444
50Other glycan degradation_Homo sapiens_hsa005110.77311903
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75655585
52Pancreatic cancer_Homo sapiens_hsa052120.73727814
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73395005
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72100715
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71659170
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71066084
57Legionellosis_Homo sapiens_hsa051340.70273755
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67917922
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65947602
60Olfactory transduction_Homo sapiens_hsa047400.65625322
61Pancreatic secretion_Homo sapiens_hsa049720.64939854
62Dorso-ventral axis formation_Homo sapiens_hsa043200.63634979
63Linoleic acid metabolism_Homo sapiens_hsa005910.60296000
64Platelet activation_Homo sapiens_hsa046110.59880421
65N-Glycan biosynthesis_Homo sapiens_hsa005100.59107235
66African trypanosomiasis_Homo sapiens_hsa051430.58306527
67FoxO signaling pathway_Homo sapiens_hsa040680.57207847
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57096360
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54831032
70Non-small cell lung cancer_Homo sapiens_hsa052230.53519651
71Thyroid hormone synthesis_Homo sapiens_hsa049180.53324936
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53253706
73VEGF signaling pathway_Homo sapiens_hsa043700.51967963
74Hematopoietic cell lineage_Homo sapiens_hsa046400.51743328
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51541177
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51179185
77Leishmaniasis_Homo sapiens_hsa051400.50178952
78Prostate cancer_Homo sapiens_hsa052150.49943816
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49221423
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.48158764
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46737413
82Long-term depression_Homo sapiens_hsa047300.46462361
83Hepatitis C_Homo sapiens_hsa051600.46216276
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46137957
85Taste transduction_Homo sapiens_hsa047420.46128736
86Insulin secretion_Homo sapiens_hsa049110.45612809
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.42960060
88Hepatitis B_Homo sapiens_hsa051610.42116588
89Type II diabetes mellitus_Homo sapiens_hsa049300.42078352
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40783239
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.39420693
92Notch signaling pathway_Homo sapiens_hsa043300.38067285
93Ras signaling pathway_Homo sapiens_hsa040140.37757612
94MicroRNAs in cancer_Homo sapiens_hsa052060.37282018
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.36839984
96Galactose metabolism_Homo sapiens_hsa000520.33099550
97Serotonergic synapse_Homo sapiens_hsa047260.32942076
98cAMP signaling pathway_Homo sapiens_hsa040240.32015418
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31694848
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30806098

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