ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	retinal rod cell development (GO:0046548)	6.91730852
2	axoneme assembly (GO:0035082)	6.58752237
3	regulation of cilium movement (GO:0003352)	6.33997209
4	cilium or flagellum-dependent cell motility (GO:0001539)	6.32078911
5	response to nitrosative stress (GO:0051409)	6.22559666
6	cilium movement (GO:0003341)	5.26045338
7	nephron epithelium morphogenesis (GO:0072088)	5.17913672
8	nephron tubule morphogenesis (GO:0072078)	5.17913672
9	brain morphogenesis (GO:0048854)	5.16722514
10	retinal cone cell development (GO:0046549)	5.12587187
11	microtubule severing (GO:0051013)	4.96341037
12	regulation of microtubule-based movement (GO:0060632)	4.75664646
13	epithelial cilium movement (GO:0003351)	4.74285718
14	protein localization to cytoskeleton (GO:0044380)	4.60773461
15	negative regulation of response to food (GO:0032096)	4.52601955
16	negative regulation of appetite (GO:0032099)	4.52601955
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.51396725
18	cellular sodium ion homeostasis (GO:0006883)	4.49645292
19	regulation of autophagic vacuole assembly (GO:2000785)	4.44800977
20	renal tubule morphogenesis (GO:0061333)	4.24476889
21	regulation of neurotransmitter uptake (GO:0051580)	4.19187134
22	spinal cord motor neuron differentiation (GO:0021522)	4.11757850
23	dendritic spine morphogenesis (GO:0060997)	4.08686919
24	protein polyglutamylation (GO:0018095)	4.04515517
25	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.93192359
26	regulation of vacuole organization (GO:0044088)	3.90370816
27	cysteine metabolic process (GO:0006534)	3.90297735
28	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.76853066
29	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.76853066
30	regulation of transmission of nerve impulse (GO:0051969)	3.76517089
31	cilium morphogenesis (GO:0060271)	3.76014390
32	adult feeding behavior (GO:0008343)	3.74268227
33	microtubule bundle formation (GO:0001578)	3.69431458
34	protein localization to microtubule cytoskeleton (GO:0072698)	3.69354180
35	regulation of synapse structural plasticity (GO:0051823)	3.68281957
36	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.65992302
37	auditory behavior (GO:0031223)	3.63653056
38	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.61052843
39	lens development in camera-type eye (GO:0002088)	3.58362505
40	regulation of response to food (GO:0032095)	3.56685057
41	axonemal dynein complex assembly (GO:0070286)	3.55114780
42	regulation of cell fate specification (GO:0042659)	3.51933727
43	urinary tract smooth muscle contraction (GO:0014848)	3.48631916
44	peptidyl-cysteine modification (GO:0018198)	3.46142692
45	sodium ion homeostasis (GO:0055078)	3.43573574
46	nonmotile primary cilium assembly (GO:0035058)	3.42861717
47	motile cilium assembly (GO:0044458)	3.42344191
48	sequestering of actin monomers (GO:0042989)	3.37853741
49	artery smooth muscle contraction (GO:0014824)	3.34949917
50	cochlea development (GO:0090102)	3.33451744
51	spinal cord association neuron differentiation (GO:0021527)	3.30344043
52	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	3.29395882
53	dorsal/ventral axis specification (GO:0009950)	3.27933213
54	epithelial cell fate commitment (GO:0072148)	3.23947407
55	mechanosensory behavior (GO:0007638)	3.16388631
56	chemosensory behavior (GO:0007635)	3.15208007
57	regulation of appetite (GO:0032098)	3.12184735
58	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.09652865
59	ventricular system development (GO:0021591)	3.07369482
60	nodal signaling pathway (GO:0038092)	3.06795704
61	adaptation of signaling pathway (GO:0023058)	3.03730771
62	protein localization to cilium (GO:0061512)	3.02473788
63	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.01453061
64	axonal fasciculation (GO:0007413)	2.98533046
65	organelle membrane fusion (GO:0090174)	2.95734300
66	water-soluble vitamin biosynthetic process (GO:0042364)	2.95305640
67	serotonin metabolic process (GO:0042428)	2.94472700
68	pyrimidine nucleobase catabolic process (GO:0006208)	2.94411718
69	sleep (GO:0030431)	2.92739010
70	positive regulation of protein depolymerization (GO:1901881)	2.92094234
71	ventricular septum development (GO:0003281)	2.85313048
72	somite rostral/caudal axis specification (GO:0032525)	2.84274836
73	intraciliary transport (GO:0042073)	2.83276317
74	response to dietary excess (GO:0002021)	2.81275376
75	tonic smooth muscle contraction (GO:0014820)	2.80103396
76	positive regulation of meiosis (GO:0045836)	2.71479432
77	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.67549216
78	behavioral response to cocaine (GO:0048148)	2.66785493
79	positive regulation of glycolytic process (GO:0045821)	2.65800066
80	protein localization to synapse (GO:0035418)	2.65774525
81	inner ear receptor stereocilium organization (GO:0060122)	2.63799350
82	fucose catabolic process (GO:0019317)	2.62008986
83	L-fucose metabolic process (GO:0042354)	2.62008986
84	L-fucose catabolic process (GO:0042355)	2.62008986
85	cilium organization (GO:0044782)	2.61730877
86	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.59377463
87	regulation of phospholipid biosynthetic process (GO:0071071)	2.59232154
88	negative regulation of systemic arterial blood pressure (GO:0003085)	2.59201619
89	positive regulation of catecholamine secretion (GO:0033605)	2.58238000
90	innervation (GO:0060384)	2.56750060
91	positive regulation of amine transport (GO:0051954)	2.56460558
92	nucleobase catabolic process (GO:0046113)	2.56081740
93	response to histamine (GO:0034776)	2.53238282
94	short-term memory (GO:0007614)	2.52444584
95	snRNA transcription (GO:0009301)	2.51626144
96	peptide hormone processing (GO:0016486)	2.50816128
97	positive regulation of meiotic cell cycle (GO:0051446)	2.50387492
98	coenzyme A biosynthetic process (GO:0015937)	2.49814567
99	synapse assembly (GO:0007416)	2.49272143
100	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.47645871

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.18310431
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.83462368
3	VDR_22108803_ChIP-Seq_LS180_Human	3.29835130
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.02478436
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.79512880
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54174403
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.42688614
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35293184
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23689322
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.23164245
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.19904869
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.17658617
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13759587
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04859041
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.02338800
16	AR_21572438_ChIP-Seq_LNCaP_Human	1.99890813
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98313864
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.96837999
19	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.95461310
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94165069
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.89079626
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.83834847
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.83834847
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.82487949
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77618867
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.72348146
27	FUS_26573619_Chip-Seq_HEK293_Human	1.69927175
28	P300_19829295_ChIP-Seq_ESCs_Human	1.69273548
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63065351
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60358691
31	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60201267
32	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58535538
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.57665440
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.57129346
35	STAT3_23295773_ChIP-Seq_U87_Human	1.56812522
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55677926
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.49347038
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43182551
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43111949
40	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41533368
41	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.40756744
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40391271
43	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.37859827
44	TCF4_23295773_ChIP-Seq_U87_Human	1.37696289
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36267657
46	EWS_26573619_Chip-Seq_HEK293_Human	1.34501558
47	AR_25329375_ChIP-Seq_VCAP_Human	1.32684863
48	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.32112323
49	P53_22387025_ChIP-Seq_ESCs_Mouse	1.31082046
50	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30600798
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29451523
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28436737
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26204883
54	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25797575
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24730192
56	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.24159883
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23712017
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22948370
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22427775
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21620784
61	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.21355855
62	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.20804297
63	KDM2B_26808549_Chip-Seq_REH_Human	1.19881155
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.18391116
65	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.17854274
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17778962
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17415615
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.13716020
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13283042
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13057671
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.12531695
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10733760
73	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.08314202
74	JUN_21703547_ChIP-Seq_K562_Human	1.07444875
75	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06860973
76	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06684470
77	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.06512884
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05667035
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04954874
80	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04314755
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.03878466
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02435954
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.02411457
84	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.02374804
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02161919
86	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02157106
87	TP53_16413492_ChIP-PET_HCT116_Human	1.02130179
88	DROSHA_22980978_ChIP-Seq_HELA_Human	1.00377437
89	TP53_22573176_ChIP-Seq_HFKS_Human	0.99767040
90	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98637768
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98637768
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98342226
93	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.97872775
94	AHR_22903824_ChIP-Seq_MCF-7_Human	0.97736169
95	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.96860460
96	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.95937815
97	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95815997
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95485292
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.93947367
100	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.93484659

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004270_analgesia	3.81848365
2	MP0002822_catalepsy	3.79274619
3	MP0005645_abnormal_hypothalamus_physiol	3.28628969
4	MP0002837_dystrophic_cardiac_calcinosis	3.28211142
5	MP0009780_abnormal_chondrocyte_physiolo	3.21448072
6	MP0008995_early_reproductive_senescence	3.09522422
7	MP0002909_abnormal_adrenal_gland	3.06873476
8	MP0002876_abnormal_thyroid_physiology	2.81076874
9	MP0003122_maternal_imprinting	2.73450547
10	MP0006072_abnormal_retinal_apoptosis	2.56072043
11	MP0001984_abnormal_olfaction	2.43854765
12	MP0005551_abnormal_eye_electrophysiolog	2.26846242
13	MP0004885_abnormal_endolymph	2.23186486
14	MP0003938_abnormal_ear_development	2.19528244
15	MP0001529_abnormal_vocalization	2.17604843
16	MP0005253_abnormal_eye_physiology	2.13339094
17	MP0002734_abnormal_mechanical_nocicepti	2.12544117
18	MP0003787_abnormal_imprinting	2.11555505
19	MP0009046_muscle_twitch	2.10484884
20	MP0002572_abnormal_emotion/affect_behav	2.09016649
21	MP0002557_abnormal_social/conspecific_i	2.04776189
22	MP0002063_abnormal_learning/memory/cond	2.00499234
23	MP0002735_abnormal_chemical_nociception	1.94990760
24	MP0001299_abnormal_eye_distance/	1.94304309
25	MP0005386_behavior/neurological_phenoty	1.79409941
26	MP0004924_abnormal_behavior	1.79409941
27	MP0000631_abnormal_neuroendocrine_gland	1.77001068
28	MP0003137_abnormal_impulse_conducting	1.74798211
29	MP0001502_abnormal_circadian_rhythm	1.72827551
30	MP0000569_abnormal_digit_pigmentation	1.72296449
31	MP0003121_genomic_imprinting	1.71071818
32	MP0003635_abnormal_synaptic_transmissio	1.66081708
33	MP0009745_abnormal_behavioral_response	1.64157283
34	MP0005379_endocrine/exocrine_gland_phen	1.62114820
35	MP0009384_cardiac_valve_regurgitation	1.60924276
36	MP0001501_abnormal_sleep_pattern	1.56348714
37	MP0002009_preneoplasia	1.51741691
38	MP0002064_seizures	1.50400688
39	MP0004742_abnormal_vestibular_system	1.50011783
40	MP0002272_abnormal_nervous_system	1.48321310
41	MP0001970_abnormal_pain_threshold	1.46429770
42	MP0000013_abnormal_adipose_tissue	1.45614974
43	MP0004142_abnormal_muscle_tone	1.44768314
44	MP0001188_hyperpigmentation	1.44481471
45	MP0008877_abnormal_DNA_methylation	1.39014140
46	MP0004215_abnormal_myocardial_fiber	1.36504443
47	MP0004133_heterotaxia	1.35374973
48	MP0002733_abnormal_thermal_nociception	1.32539037
49	MP0001944_abnormal_pancreas_morphology	1.31283204
50	MP0001765_abnormal_ion_homeostasis	1.30243250
51	MP0002067_abnormal_sensory_capabilities	1.27043111
52	MP0003937_abnormal_limbs/digits/tail_de	1.25188025
53	MP0005220_abnormal_exocrine_pancreas	1.24432425
54	MP0004019_abnormal_vitamin_homeostasis	1.23841957
55	MP0001968_abnormal_touch/_nociception	1.23209756
56	MP0002693_abnormal_pancreas_physiology	1.22444384
57	MP0003567_abnormal_fetal_cardiomyocyte	1.22396517
58	MP0000566_synostosis	1.14623650
59	MP0005310_abnormal_salivary_gland	1.14622410
60	MP0000026_abnormal_inner_ear	1.13295608
61	MP0001486_abnormal_startle_reflex	1.11055112
62	MP0001986_abnormal_taste_sensitivity	1.10420892
63	MP0001324_abnormal_eye_pigmentation	1.07876960
64	MP0000427_abnormal_hair_cycle	1.05360958
65	MP0003633_abnormal_nervous_system	1.04565306
66	MP0003329_amyloid_beta_deposits	1.03994822
67	MP0005332_abnormal_amino_acid	1.02703896
68	MP0005623_abnormal_meninges_morphology	1.02572448
69	MP0002069_abnormal_eating/drinking_beha	1.02278513
70	MP0010329_abnormal_lipoprotein_level	1.02258348
71	MP0005535_abnormal_body_temperature	1.01728238
72	MP0005083_abnormal_biliary_tract	1.00878156
73	MP0001905_abnormal_dopamine_level	0.99224150
74	MP0008961_abnormal_basal_metabolism	0.98066089
75	MP0002184_abnormal_innervation	0.97962524
76	MP0002139_abnormal_hepatobiliary_system	0.96076012
77	MP0002163_abnormal_gland_morphology	0.95835836
78	MP0003879_abnormal_hair_cell	0.95833966
79	MP0005636_abnormal_mineral_homeostasis	0.94786490
80	MP0002736_abnormal_nociception_after	0.92439618
81	MP0000383_abnormal_hair_follicle	0.90642730
82	MP0002229_neurodegeneration	0.90259070
83	MP0002882_abnormal_neuron_morphology	0.89667829
84	MP0001440_abnormal_grooming_behavior	0.87982370
85	MP0005195_abnormal_posterior_eye	0.87343105
86	MP0002066_abnormal_motor_capabilities/c	0.86766837
87	MP0005448_abnormal_energy_balance	0.86728383
88	MP0002078_abnormal_glucose_homeostasis	0.86608638
89	MP0008789_abnormal_olfactory_epithelium	0.86593618
90	MP0004085_abnormal_heartbeat	0.84923119
91	MP0004811_abnormal_neuron_physiology	0.84536408
92	MP0003195_calcinosis	0.83827832
93	MP0001756_abnormal_urination	0.77925687
94	MP0002102_abnormal_ear_morphology	0.76222668
95	MP0010678_abnormal_skin_adnexa	0.75909349
96	MP0002752_abnormal_somatic_nervous	0.75203640
97	MP0004859_abnormal_synaptic_plasticity	0.74679420
98	MP0003953_abnormal_hormone_level	0.70671104
99	MP0005391_vision/eye_phenotype	0.68604893
100	MP0005646_abnormal_pituitary_gland	0.67364557

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased circulating renin level (HP:0003351)	7.93958845
2	Hyperactive renin-angiotensin system (HP:0000841)	7.37131068
3	Increased circulating renin level (HP:0000848)	6.83320202
4	Hyperkalemia (HP:0002153)	6.70984827
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.50406766
6	Absent/shortened dynein arms (HP:0200106)	5.50406766
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.35869436
8	Hyperaldosteronism (HP:0000859)	4.48255154
9	Abnormal respiratory motile cilium physiology (HP:0012261)	4.37613252
10	Toxemia of pregnancy (HP:0100603)	4.27247198
11	Nuclear cataract (HP:0100018)	4.14744552
12	Chronic bronchitis (HP:0004469)	4.02956684
13	Abnormal ciliary motility (HP:0012262)	3.97418851
14	Abnormality of renin-angiotensin system (HP:0000847)	3.94954482
15	Abnormal respiratory motile cilium morphology (HP:0005938)	3.89779355
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.89779355
17	Agitation (HP:0000713)	3.87313295
18	Retinal atrophy (HP:0001105)	3.75393826
19	Rhinitis (HP:0012384)	3.43947721
20	Congenital malformation of the right heart (HP:0011723)	3.39080865
21	Double outlet right ventricle (HP:0001719)	3.39080865
22	Abnormality of potassium homeostasis (HP:0011042)	3.35941532
23	Genetic anticipation (HP:0003743)	3.33345639
24	Severe visual impairment (HP:0001141)	3.32013734
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.10021041
26	Progressive cerebellar ataxia (HP:0002073)	3.09086009
27	Abnormality of chloride homeostasis (HP:0011422)	3.02601103
28	Limb dystonia (HP:0002451)	2.99418701
29	Intestinal atresia (HP:0011100)	2.94503050
30	Myokymia (HP:0002411)	2.88039841
31	Hyponatremia (HP:0002902)	2.87043774
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.77322800
33	Pendular nystagmus (HP:0012043)	2.70687688
34	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.70189115
35	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.70189115
36	Polyphagia (HP:0002591)	2.63148357
37	Action tremor (HP:0002345)	2.61940087
38	Gait imbalance (HP:0002141)	2.51157688
39	Sensory axonal neuropathy (HP:0003390)	2.50996131
40	Chronic hepatic failure (HP:0100626)	2.44038678
41	Labial hypoplasia (HP:0000066)	2.43234504
42	Macroorchidism (HP:0000053)	2.19181997
43	Abnormality of sodium homeostasis (HP:0010931)	2.18637053
44	Bronchiectasis (HP:0002110)	2.16795559
45	Adrenal overactivity (HP:0002717)	2.16251936
46	Hypoplastic female external genitalia (HP:0012815)	2.14408553
47	Insidious onset (HP:0003587)	2.12479885
48	Termporal pattern (HP:0011008)	2.12479885
49	Papilledema (HP:0001085)	2.11708787
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08818675
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08818675
52	Congenital cataract (HP:0000519)	2.07966196
53	Abnormality of the corticospinal tract (HP:0002492)	2.02203397
54	Increased hepatocellular lipid droplets (HP:0006565)	2.01400596
55	Broad-based gait (HP:0002136)	1.99081834
56	Lipid accumulation in hepatocytes (HP:0006561)	1.95901020
57	Bony spicule pigmentary retinopathy (HP:0007737)	1.95411403
58	Depression (HP:0000716)	1.94649757
59	Nephrogenic diabetes insipidus (HP:0009806)	1.93156659
60	Hematochezia (HP:0002573)	1.89418872
61	Congenital primary aphakia (HP:0007707)	1.88161673
62	Postural tremor (HP:0002174)	1.87715839
63	Medial flaring of the eyebrow (HP:0010747)	1.87710855
64	Oligodactyly (hands) (HP:0001180)	1.87402074
65	Absent eyebrow (HP:0002223)	1.87046051
66	Colon cancer (HP:0003003)	1.86718127
67	Hyperventilation (HP:0002883)	1.86094580
68	Pancreatic fibrosis (HP:0100732)	1.83194501
69	Bronchitis (HP:0012387)	1.83101574
70	Zonular cataract (HP:0010920)	1.82953416
71	Neonatal respiratory distress (HP:0002643)	1.82875815
72	Hypoplastic labia majora (HP:0000059)	1.80170464
73	Genital tract atresia (HP:0001827)	1.79407330
74	Gaze-evoked nystagmus (HP:0000640)	1.78844277
75	Renal Fanconi syndrome (HP:0001994)	1.77987835
76	Disinhibition (HP:0000734)	1.77647640
77	Restlessness (HP:0000711)	1.77178911
78	Large for gestational age (HP:0001520)	1.76130840
79	Congenital stationary night blindness (HP:0007642)	1.75942247
80	Hypotension (HP:0002615)	1.74255213
81	True hermaphroditism (HP:0010459)	1.74158819
82	Nephronophthisis (HP:0000090)	1.73949446
83	Dysmetric saccades (HP:0000641)	1.73716399
84	Abnormality of the labia (HP:0000058)	1.72457692
85	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.71250746
86	Limb hypertonia (HP:0002509)	1.70117003
87	Tubulointerstitial nephritis (HP:0001970)	1.69071301
88	Progressive sensorineural hearing impairment (HP:0000408)	1.68972500
89	Molar tooth sign on MRI (HP:0002419)	1.68939529
90	Abnormality of midbrain morphology (HP:0002418)	1.68939529
91	Unilateral renal agenesis (HP:0000122)	1.67309062
92	Progressive macrocephaly (HP:0004481)	1.65190593
93	Epileptic encephalopathy (HP:0200134)	1.63606514
94	Popliteal pterygium (HP:0009756)	1.62895748
95	Abnormality of the labia majora (HP:0012881)	1.62029199
96	Hypokalemic alkalosis (HP:0001949)	1.61027441
97	Hypoalbuminemia (HP:0003073)	1.60961978
98	Abnormal albumin level (HP:0012116)	1.60961978
99	Hypokalemia (HP:0002900)	1.60258093
100	Vaginal atresia (HP:0000148)	1.60177714

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	6.13124192
2	CASK	5.39295596
3	MARK1	4.30175957
4	MAP2K6	4.20421822
5	MAP3K9	2.94950146
6	DAPK2	2.68253680
7	IRAK4	2.62415711
8	MAP3K2	2.50720965
9	TNIK	2.41904188
10	MAP3K3	2.35542373
11	PHKG1	2.31280358
12	PHKG2	2.31280358
13	BCR	2.15808116
14	FRK	2.08528256
15	MKNK2	1.87423872
16	MAP3K4	1.80491421
17	PAK3	1.75345961
18	MAP2K7	1.65231122
19	MAPK13	1.62810281
20	PINK1	1.59174345
21	NTRK3	1.54421470
22	GRK1	1.43641522
23	NTRK2	1.42131925
24	DYRK2	1.31486149
25	BMPR1B	1.30487523
26	EPHB2	1.27447316
27	ADRBK2	1.24140337
28	PLK2	1.20749876
29	KSR1	1.10987944
30	ZAK	1.05996856
31	TAOK1	1.05717120
32	PRKCG	1.04220115
33	CSNK1A1L	1.03526028
34	MAP2K4	1.02426338
35	MST4	0.98707133
36	MAP4K2	0.92364919
37	SGK1	0.87893225
38	ERBB2	0.87079918
39	INSRR	0.84421307
40	CSNK1G2	0.84311374
41	DYRK1A	0.79602481
42	CSNK1G3	0.76657474
43	MKNK1	0.76034555
44	PRKCE	0.74259670
45	PKN1	0.73130677
46	PRKD3	0.72966601
47	UHMK1	0.72065953
48	PRKCI	0.69072376
49	LIMK1	0.68873514
50	CSNK1D	0.68133546
51	CSNK1G1	0.60453971
52	ERBB3	0.58882828
53	NLK	0.58356508
54	PRKCZ	0.57952832
55	SGK223	0.56250395
56	SGK494	0.56250395
57	CDK12	0.56052808
58	CAMK2A	0.53728085
59	WNK4	0.51526874
60	CSNK1E	0.51242112
61	MAP2K2	0.51046233
62	TAOK3	0.48337445
63	ACVR1B	0.47588878
64	STK11	0.46287606
65	MAPK12	0.45580260
66	PDK2	0.44919852
67	MAP3K6	0.44304412
68	EPHA4	0.43635274
69	CDK5	0.42751267
70	MAPK15	0.42156472
71	MARK2	0.41909781
72	PRKACB	0.41296664
73	STK16	0.40766339
74	RPS6KA3	0.38161342
75	CAMK1	0.36695029
76	ALK	0.36175375
77	AKT2	0.36049307
78	EIF2AK2	0.35630025
79	CAMK2D	0.33864772
80	CSNK1A1	0.33351830
81	RPS6KA4	0.32941555
82	MAP2K1	0.29755717
83	PRKCB	0.29752932
84	ZAP70	0.28916091
85	MUSK	0.28220814
86	MAPK8	0.27349008
87	SGK2	0.27072879
88	MAPK4	0.27056378
89	NME1	0.26803317
90	MINK1	0.26199848
91	PRKACA	0.25494388
92	PRKG1	0.24806016
93	CHUK	0.24186520
94	GSK3B	0.23570109
95	CAMK2B	0.23065325
96	ADRBK1	0.23040096
97	PTK6	0.21833191
98	RPS6KB1	0.21197394
99	PRKAA1	0.20313886
100	ROCK2	0.18854358

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.98876863
2	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.81995521
3	Sulfur metabolism_Homo sapiens_hsa00920	2.76530569
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.72724917
5	Morphine addiction_Homo sapiens_hsa05032	2.67736991
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.46494109
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.36406862
8	Circadian rhythm_Homo sapiens_hsa04710	2.34980322
9	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.33044696
10	Protein export_Homo sapiens_hsa03060	2.29714237
11	Serotonergic synapse_Homo sapiens_hsa04726	2.12167205
12	Folate biosynthesis_Homo sapiens_hsa00790	2.11524708
13	Sulfur relay system_Homo sapiens_hsa04122	2.07721632
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.06163390
15	GABAergic synapse_Homo sapiens_hsa04727	1.97944115
16	Parkinsons disease_Homo sapiens_hsa05012	1.89122517
17	Huntingtons disease_Homo sapiens_hsa05016	1.86166420
18	Circadian entrainment_Homo sapiens_hsa04713	1.74616963
19	Phototransduction_Homo sapiens_hsa04744	1.64445662
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.63349777
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.60253356
22	Alzheimers disease_Homo sapiens_hsa05010	1.60201223
23	Dopaminergic synapse_Homo sapiens_hsa04728	1.58492744
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58352697
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.57927130
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.55513691
27	Taste transduction_Homo sapiens_hsa04742	1.52945322
28	Insulin secretion_Homo sapiens_hsa04911	1.49531187
29	ABC transporters_Homo sapiens_hsa02010	1.39435960
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34552037
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31312384
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.24924119
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23473442
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22191785
35	Peroxisome_Homo sapiens_hsa04146	1.17302123
36	Regulation of autophagy_Homo sapiens_hsa04140	1.15988340
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.12211050
38	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.10697112
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09793386
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.06198826
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.06158007
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05203187
43	Cocaine addiction_Homo sapiens_hsa05030	0.99468266
44	Renal cell carcinoma_Homo sapiens_hsa05211	0.93813127
45	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93281207
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.93072267
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.92624895
48	Sphingolipid metabolism_Homo sapiens_hsa00600	0.87883356
49	Gap junction_Homo sapiens_hsa04540	0.87114595
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.86856533
51	Gastric acid secretion_Homo sapiens_hsa04971	0.85317298
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83145825
53	Butanoate metabolism_Homo sapiens_hsa00650	0.82928607
54	Glutathione metabolism_Homo sapiens_hsa00480	0.81549939
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79339042
56	Ras signaling pathway_Homo sapiens_hsa04014	0.78330209
57	Long-term depression_Homo sapiens_hsa04730	0.78252934
58	Olfactory transduction_Homo sapiens_hsa04740	0.77967152
59	Amphetamine addiction_Homo sapiens_hsa05031	0.76549350
60	Retinol metabolism_Homo sapiens_hsa00830	0.73309087
61	Salivary secretion_Homo sapiens_hsa04970	0.73238972
62	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.70955509
63	Cholinergic synapse_Homo sapiens_hsa04725	0.69581549
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.68092446
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67956405
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63620668
67	Arginine biosynthesis_Homo sapiens_hsa00220	0.63472291
68	Basal transcription factors_Homo sapiens_hsa03022	0.62783652
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59602636
70	Renin secretion_Homo sapiens_hsa04924	0.59007548
71	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.58921823
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56666453
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55302437
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.53101332
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52202033
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52059374
77	Histidine metabolism_Homo sapiens_hsa00340	0.51671032
78	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.50218700
79	Axon guidance_Homo sapiens_hsa04360	0.47403833
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.45142580
81	Melanogenesis_Homo sapiens_hsa04916	0.44268222
82	Tight junction_Homo sapiens_hsa04530	0.43857549
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.43672466
84	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43162782
85	Pancreatic secretion_Homo sapiens_hsa04972	0.42127652
86	Oocyte meiosis_Homo sapiens_hsa04114	0.41984705
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.41402088
88	Phenylalanine metabolism_Homo sapiens_hsa00360	0.40963459
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.40728275
90	Metabolic pathways_Homo sapiens_hsa01100	0.37035795
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.36474508
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35231144
93	GnRH signaling pathway_Homo sapiens_hsa04912	0.35229038
94	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.34875207
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34311597
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34141639
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.33307521
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33180802
99	Bile secretion_Homo sapiens_hsa04976	0.32136874
100	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.31929631

HMGB3P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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