HMGB3P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)6.98099251
2negative regulation of translation, ncRNA-mediated (GO:0040033)6.98099251
3regulation of translation, ncRNA-mediated (GO:0045974)6.98099251
4synaptic transmission, cholinergic (GO:0007271)6.94087694
5regulation of posttranscriptional gene silencing (GO:0060147)6.70857073
6regulation of gene silencing by miRNA (GO:0060964)6.70857073
7regulation of gene silencing by RNA (GO:0060966)6.70857073
8endoderm formation (GO:0001706)6.05551226
9protein polyglutamylation (GO:0018095)5.92831076
10regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.70752794
11positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.70752794
12pyrimidine nucleobase catabolic process (GO:0006208)5.64723259
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.59136274
14regulation of synapse structural plasticity (GO:0051823)5.22520824
15regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)5.16073037
16positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO5.16073037
17cerebral cortex neuron differentiation (GO:0021895)4.99174441
18N-glycan processing (GO:0006491)4.96527785
19behavioral response to nicotine (GO:0035095)4.94304650
20postsynaptic membrane organization (GO:0001941)4.87434380
21olfactory bulb development (GO:0021772)4.74771627
22head development (GO:0060322)4.73706325
23nucleobase catabolic process (GO:0046113)4.73660698
24nuclear envelope reassembly (GO:0031468)4.64350330
25mitotic nuclear envelope reassembly (GO:0007084)4.64350330
26protein K11-linked deubiquitination (GO:0035871)4.41750723
27cytoplasmic mRNA processing body assembly (GO:0033962)4.37105603
28central nervous system projection neuron axonogenesis (GO:0021952)4.25523144
29intraciliary transport (GO:0042073)4.24558276
30positive regulation of mRNA catabolic process (GO:0061014)3.99895107
31positive regulation of neurological system process (GO:0031646)3.87006540
32myoblast fusion (GO:0007520)3.73590122
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68607409
34aggressive behavior (GO:0002118)3.62257774
35tachykinin receptor signaling pathway (GO:0007217)3.59332554
36positive regulation of mRNA 3-end processing (GO:0031442)3.53331170
37regulation of mRNA catabolic process (GO:0061013)3.48360001
38detection of mechanical stimulus involved in sensory perception (GO:0050974)3.44947801
39regulation of mRNA 3-end processing (GO:0031440)3.42909196
40central nervous system neuron axonogenesis (GO:0021955)3.39060240
41positive regulation of antigen processing and presentation (GO:0002579)3.31460814
42positive regulation of muscle cell apoptotic process (GO:0010661)3.27980172
43long-chain fatty acid biosynthetic process (GO:0042759)3.21620761
44syncytium formation by plasma membrane fusion (GO:0000768)3.21600557
45epithelial cilium movement (GO:0003351)3.21479193
46adaptation of signaling pathway (GO:0023058)3.20415786
47brain morphogenesis (GO:0048854)3.19579397
48syncytium formation (GO:0006949)3.18420356
49meiotic chromosome segregation (GO:0045132)3.15325484
50histone H3-K4 trimethylation (GO:0080182)3.05400398
51axon extension (GO:0048675)3.02860217
52establishment or maintenance of monopolar cell polarity (GO:0061339)3.02182358
53establishment of monopolar cell polarity (GO:0061162)3.02182358
54cilium morphogenesis (GO:0060271)3.01296425
55spinal cord development (GO:0021510)2.98557472
56ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.94680505
57cell proliferation in forebrain (GO:0021846)2.88504539
58somite development (GO:0061053)2.88204297
59positive regulation of T-helper 1 type immune response (GO:0002827)2.85620469
60negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84775650
61calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84077835
62mitochondrion distribution (GO:0048311)2.79751423
63peptidyl-histidine modification (GO:0018202)2.77734687
64Sertoli cell development (GO:0060009)2.75403309
65behavioral response to ethanol (GO:0048149)2.74886993
66regulation of smooth muscle cell apoptotic process (GO:0034391)2.74446167
67ganglion development (GO:0061548)2.74257089
68regulation of hippo signaling (GO:0035330)2.73289506
69positive regulation of histone H3-K4 methylation (GO:0051571)2.73243898
70glycosphingolipid biosynthetic process (GO:0006688)2.71294090
71coenzyme catabolic process (GO:0009109)2.70060794
72positive regulation of mRNA processing (GO:0050685)2.68627445
73negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.68051628
74neuron projection extension (GO:1990138)2.66956294
75serotonin metabolic process (GO:0042428)2.66293920
76synapse assembly (GO:0007416)2.66184112
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64808995
78detection of calcium ion (GO:0005513)2.64075381
79regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63354305
80thyroid hormone metabolic process (GO:0042403)2.62498996
81negative regulation of multicellular organism growth (GO:0040015)2.62363923
82substantia nigra development (GO:0021762)2.62095765
83positive regulation of amino acid transport (GO:0051957)2.61723843
84negative regulation of sodium ion transport (GO:0010766)2.61525584
85regulation of Rac protein signal transduction (GO:0035020)2.58535740
86response to pheromone (GO:0019236)2.58134708
87neurofilament cytoskeleton organization (GO:0060052)2.58012309
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.57328594
89regulation of glycogen (starch) synthase activity (GO:2000465)2.55371648
90positive regulation of vesicle fusion (GO:0031340)2.55186351
91regulation of calcium ion-dependent exocytosis (GO:0017158)2.54310109
92regulation of somitogenesis (GO:0014807)2.52709721
93presynaptic membrane assembly (GO:0097105)2.52258680
94establishment of nucleus localization (GO:0040023)2.50021944
95stress granule assembly (GO:0034063)2.49409566
96inositol metabolic process (GO:0006020)2.49245684
97transmission of nerve impulse (GO:0019226)2.48229940
98gene silencing by RNA (GO:0031047)2.47873225
99phospholipid translocation (GO:0045332)2.47684596
100lipid translocation (GO:0034204)2.47684596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.19615762
2GBX2_23144817_ChIP-Seq_PC3_Human2.91572517
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.67584100
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59716976
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58524848
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49784339
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.48186251
8RNF2_27304074_Chip-Seq_NSC_Mouse2.19171718
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10715683
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.09922455
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99870554
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97829730
13POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90220451
14SMAD4_21799915_ChIP-Seq_A2780_Human1.88060827
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86167563
16P300_19829295_ChIP-Seq_ESCs_Human1.84277018
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83040757
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82758395
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81218497
20MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76181312
21FUS_26573619_Chip-Seq_HEK293_Human1.71647936
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68677417
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64779538
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.60287831
25ER_23166858_ChIP-Seq_MCF-7_Human1.60203121
26REST_21632747_ChIP-Seq_MESCs_Mouse1.59640980
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59368401
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56417040
29STAT3_23295773_ChIP-Seq_U87_Human1.56022664
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.50972433
31VDR_22108803_ChIP-Seq_LS180_Human1.50361395
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.47859709
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44836095
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44285404
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43532480
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41825821
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40757397
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.40753541
39AR_25329375_ChIP-Seq_VCAP_Human1.39652738
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39480919
41IGF1R_20145208_ChIP-Seq_DFB_Human1.39342285
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39057838
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37834053
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.36324644
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36121469
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.35131072
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34495003
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34495003
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34255249
50TP53_16413492_ChIP-PET_HCT116_Human1.33941151
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33825989
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32322829
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31829242
54P53_22387025_ChIP-Seq_ESCs_Mouse1.31002616
55ZNF274_21170338_ChIP-Seq_K562_Hela1.29477551
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29394759
57AHR_22903824_ChIP-Seq_MCF-7_Human1.27295663
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.27077599
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.26947230
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.26721013
61TCF4_23295773_ChIP-Seq_U87_Human1.26649009
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26184760
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24130254
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23082248
65TCF4_22108803_ChIP-Seq_LS180_Human1.21273980
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.20144254
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18238710
68CBP_20019798_ChIP-Seq_JUKART_Human1.18238710
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17913161
70SOX9_26525672_Chip-Seq_HEART_Mouse1.17889732
71TBL1_22424771_ChIP-Seq_293T_Human1.16879065
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.15990547
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15780747
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14276533
75TAF15_26573619_Chip-Seq_HEK293_Human1.13976214
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13757187
77EWS_26573619_Chip-Seq_HEK293_Human1.13539911
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.13335799
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12949752
80AR_19668381_ChIP-Seq_PC3_Human1.12856265
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12093125
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11899811
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10391936
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.10096617
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09569311
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09550273
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08524181
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.08260143
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07604589
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.07419550
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05722069
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05713401
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05612066
94BCAT_22108803_ChIP-Seq_LS180_Human1.05506600
95P300_18555785_Chip-Seq_ESCs_Mouse1.05058882
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.04326828
97KDM2B_26808549_Chip-Seq_REH_Human1.02879062
98CDX2_22108803_ChIP-Seq_LS180_Human1.01981630
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01981100
100RUNX2_22187159_ChIP-Seq_PCA_Human1.01482922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous4.08028427
2MP0006072_abnormal_retinal_apoptosis3.74486725
3MP0003880_abnormal_central_pattern3.45583573
4MP0006276_abnormal_autonomic_nervous3.43459657
5MP0005083_abnormal_biliary_tract3.10445074
6MP0003787_abnormal_imprinting3.09876910
7MP0000778_abnormal_nervous_system3.04463626
8MP0004147_increased_porphyrin_level2.99724540
9MP0003879_abnormal_hair_cell2.95742057
10MP0008877_abnormal_DNA_methylation2.92199804
11MP0003890_abnormal_embryonic-extraembry2.73914427
12MP0008057_abnormal_DNA_replication2.62272244
13MP0003121_genomic_imprinting2.52108118
14MP0003122_maternal_imprinting2.25100548
15MP0000427_abnormal_hair_cycle2.20760049
16MP0005670_abnormal_white_adipose2.17407882
17MP0004043_abnormal_pH_regulation2.07554150
18MP0005253_abnormal_eye_physiology2.07209500
19MP0005645_abnormal_hypothalamus_physiol1.97579179
20MP0005171_absent_coat_pigmentation1.89483401
21MP0000955_abnormal_spinal_cord1.88584440
22MP0009046_muscle_twitch1.84891181
23MP0001324_abnormal_eye_pigmentation1.77947622
24MP0002234_abnormal_pharynx_morphology1.71747649
25MP0003123_paternal_imprinting1.71703874
26MP0002184_abnormal_innervation1.61487275
27MP0002557_abnormal_social/conspecific_i1.58936075
28MP0004142_abnormal_muscle_tone1.56693338
29MP0002751_abnormal_autonomic_nervous1.52152507
30MP0004885_abnormal_endolymph1.51860746
31MP0002009_preneoplasia1.45172874
32MP0005084_abnormal_gallbladder_morpholo1.41244433
33MP0002095_abnormal_skin_pigmentation1.38803923
34MP0002752_abnormal_somatic_nervous1.34075317
35MP0004811_abnormal_neuron_physiology1.30715542
36MP0005195_abnormal_posterior_eye1.30624935
37MP0005551_abnormal_eye_electrophysiolog1.28804506
38MP0009780_abnormal_chondrocyte_physiolo1.28339915
39MP0002837_dystrophic_cardiac_calcinosis1.27608567
40MP0002735_abnormal_chemical_nociception1.24035448
41MP0001486_abnormal_startle_reflex1.23260467
42MP0001440_abnormal_grooming_behavior1.23225470
43MP0001905_abnormal_dopamine_level1.19693140
44MP0000566_synostosis1.17921793
45MP0000049_abnormal_middle_ear1.16970231
46MP0004084_abnormal_cardiac_muscle1.15823559
47MP0002067_abnormal_sensory_capabilities1.13274406
48MP0004924_abnormal_behavior1.12985547
49MP0005386_behavior/neurological_phenoty1.12985547
50MP0003252_abnormal_bile_duct1.11536725
51MP0001188_hyperpigmentation1.10644911
52MP0003943_abnormal_hepatobiliary_system1.10138288
53MP0002882_abnormal_neuron_morphology1.07590951
54MP0003635_abnormal_synaptic_transmissio1.05269431
55MP0002572_abnormal_emotion/affect_behav1.03028844
56MP0000569_abnormal_digit_pigmentation1.01497409
57MP0001348_abnormal_lacrimal_gland1.01347231
58MP0009745_abnormal_behavioral_response1.00440365
59MP0000613_abnormal_salivary_gland1.00058434
60MP0002272_abnormal_nervous_system0.97896997
61MP0002269_muscular_atrophy0.95301970
62MP0003959_abnormal_lean_body0.94888154
63MP0002063_abnormal_learning/memory/cond0.92459064
64MP0002295_abnormal_pulmonary_circulatio0.91565160
65MP0000631_abnormal_neuroendocrine_gland0.88618331
66MP0001963_abnormal_hearing_physiology0.88540831
67MP0003115_abnormal_respiratory_system0.88504768
68MP0005174_abnormal_tail_pigmentation0.87474810
69MP0005391_vision/eye_phenotype0.83661985
70MP0002734_abnormal_mechanical_nocicepti0.83275841
71MP0001485_abnormal_pinna_reflex0.82993192
72MP0004133_heterotaxia0.82153970
73MP0002877_abnormal_melanocyte_morpholog0.80977843
74MP0002229_neurodegeneration0.80635407
75MP0003937_abnormal_limbs/digits/tail_de0.79631116
76MP0002928_abnormal_bile_duct0.79596848
77MP0003633_abnormal_nervous_system0.78623124
78MP0004484_altered_response_of0.77790074
79MP0001299_abnormal_eye_distance/0.76768615
80MP0000015_abnormal_ear_pigmentation0.76627555
81MP0005266_abnormal_metabolism0.76574921
82MP0001286_abnormal_eye_development0.75880829
83MP0002282_abnormal_trachea_morphology0.75439169
84MP0008770_decreased_survivor_rate0.73689877
85MP0004859_abnormal_synaptic_plasticity0.73557575
86MP0000647_abnormal_sebaceous_gland0.73477946
87MP0004270_analgesia0.71836238
88MP0002733_abnormal_thermal_nociception0.71316629
89MP0003861_abnormal_nervous_system0.70444803
90MP0008995_early_reproductive_senescence0.70224408
91MP0003385_abnormal_body_wall0.69598416
92MP0004215_abnormal_myocardial_fiber0.69448696
93MP0002332_abnormal_exercise_endurance0.68149255
94MP0005360_urolithiasis0.67598831
95MP0002152_abnormal_brain_morphology0.66771434
96MP0004145_abnormal_muscle_electrophysio0.66274509
97MP0008775_abnormal_heart_ventricle0.64724087
98MP0001944_abnormal_pancreas_morphology0.64098261
99MP0003183_abnormal_peptide_metabolism0.64088020
100MP0000372_irregular_coat_pigmentation0.63944791

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)7.24504078
2Abnormality of the corticospinal tract (HP:0002492)5.53645704
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.17658898
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.17658898
5Spinal muscular atrophy (HP:0007269)4.82129939
6High anterior hairline (HP:0009890)3.73082709
7Shawl scrotum (HP:0000049)3.62963220
8Genetic anticipation (HP:0003743)3.54096031
9Coronal craniosynostosis (HP:0004440)3.52326883
10Molar tooth sign on MRI (HP:0002419)3.41615833
11Abnormality of midbrain morphology (HP:0002418)3.41615833
12Breast hypoplasia (HP:0003187)3.28890708
13Urinary bladder sphincter dysfunction (HP:0002839)3.12081272
14Impaired vibration sensation in the lower limbs (HP:0002166)2.85000668
15Morphological abnormality of the pyramidal tract (HP:0002062)2.76458910
16Increased number of teeth (HP:0011069)2.76088352
17Diastasis recti (HP:0001540)2.75883423
18True hermaphroditism (HP:0010459)2.75686873
19Small hand (HP:0200055)2.70903851
20Nephronophthisis (HP:0000090)2.68393881
21Decreased muscle mass (HP:0003199)2.65949961
22Type 2 muscle fiber atrophy (HP:0003554)2.63501442
23Pancreatic fibrosis (HP:0100732)2.63106172
24Pancreatic cysts (HP:0001737)2.62841899
25Drooling (HP:0002307)2.61830001
26Pendular nystagmus (HP:0012043)2.58415210
27Lissencephaly (HP:0001339)2.57789824
28Thickened helices (HP:0000391)2.57021942
29Severe visual impairment (HP:0001141)2.56003504
30Gaze-evoked nystagmus (HP:0000640)2.53003511
31Exotropia (HP:0000577)2.49457233
32Truncal obesity (HP:0001956)2.48937024
33Polyphagia (HP:0002591)2.44740239
34Colon cancer (HP:0003003)2.42969667
35Hypercholesterolemia (HP:0003124)2.36877934
36Excessive salivation (HP:0003781)2.35835999
37Abnormality of incisor morphology (HP:0011063)2.34488971
38Insidious onset (HP:0003587)2.32868008
39Termporal pattern (HP:0011008)2.32868008
40Gait imbalance (HP:0002141)2.32626801
41Progressive cerebellar ataxia (HP:0002073)2.31988714
42Paraplegia (HP:0010550)2.23023093
43Nephrogenic diabetes insipidus (HP:0009806)2.22833516
44Pachygyria (HP:0001302)2.19866738
45Fatigable weakness (HP:0003473)2.17049664
46Abnormality of the neuromuscular junction (HP:0003398)2.17049664
47Muscle fiber atrophy (HP:0100295)2.16545657
48Irregular vertebral endplates (HP:0003301)2.15950441
49Nonprogressive disorder (HP:0003680)2.15614545
50Medial flaring of the eyebrow (HP:0010747)2.13316555
51Slow-growing hair (HP:0002217)2.13194609
52Abnormality of hair growth rate (HP:0011363)2.13194609
53Hypoplastic iliac wings (HP:0002866)2.12180337
54Down-sloping shoulders (HP:0200021)2.09179251
55Turricephaly (HP:0000262)2.08103017
56Midline defect of the nose (HP:0004122)2.07489025
57Abnormality of the renal medulla (HP:0100957)2.07230433
58Disproportionate short-trunk short stature (HP:0003521)2.04421953
59Weak cry (HP:0001612)2.03680097
60Poor coordination (HP:0002370)2.02829477
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.98821519
62Congenital primary aphakia (HP:0007707)1.96635185
63Birth length less than 3rd percentile (HP:0003561)1.96362007
64Trigonocephaly (HP:0000243)1.93024435
65Partial agenesis of the corpus callosum (HP:0001338)1.91001564
66Spastic tetraplegia (HP:0002510)1.90660885
67Chronic hepatic failure (HP:0100626)1.90360590
68Intestinal atresia (HP:0011100)1.89156629
69Woolly hair (HP:0002224)1.88392779
70Thickened nuchal skin fold (HP:0000474)1.86840864
71Focal seizures (HP:0007359)1.86776520
72Plagiocephaly (HP:0001357)1.84305176
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84030843
74Abnormal pancreas size (HP:0012094)1.82944671
75Labial hypoplasia (HP:0000066)1.81456146
76Occipital encephalocele (HP:0002085)1.80078049
77Fetal akinesia sequence (HP:0001989)1.79181957
78Sclerocornea (HP:0000647)1.78048018
79Cutaneous syndactyly (HP:0012725)1.75779011
80Sandal gap (HP:0001852)1.74613544
81Pterygium (HP:0001059)1.74284007
82Abnormality of the vertebral endplates (HP:0005106)1.74041691
83Absent speech (HP:0001344)1.72452882
84Agitation (HP:0000713)1.72405466
85Autoamputation (HP:0001218)1.71400933
86Attenuation of retinal blood vessels (HP:0007843)1.71173697
87Difficulty running (HP:0009046)1.71010706
88Aplasia/Hypoplasia of the nipples (HP:0006709)1.70943292
89Urinary urgency (HP:0000012)1.69618155
90Preaxial foot polydactyly (HP:0001841)1.68792964
91Hip dysplasia (HP:0001385)1.68137668
92Abnormality of the ischium (HP:0003174)1.67444303
93Prolonged QT interval (HP:0001657)1.65742600
94Fibular hypoplasia (HP:0003038)1.65647712
95Papillary thyroid carcinoma (HP:0002895)1.63389336
96Abnormality of dental color (HP:0011073)1.63317819
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.62805813
98Bony spicule pigmentary retinopathy (HP:0007737)1.62759004
99Oligodactyly (hands) (HP:0001180)1.61775839
100Cutaneous finger syndactyly (HP:0010554)1.61391784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.23012601
2DYRK1B4.59801877
3FRK3.86989536
4MARK13.42113845
5MAP3K122.99493245
6WNK32.56620021
7AKT32.39636901
8ICK2.15211600
9OXSR12.10555235
10NTRK11.96500528
11YES11.75631291
12DYRK21.74183430
13CASK1.72586655
14MAP3K61.62971704
15MAP3K111.55024523
16NTRK21.54760727
17NME11.53054580
18CDK191.45741876
19MKNK21.45388023
20GRK51.42557646
21PAK31.42070800
22CAMK1D1.37853462
23MAP3K41.37314349
24CSNK1G21.36769455
25SGK21.36329209
26CSNK1A1L1.35266748
27MARK21.33266552
28MAP2K71.32771949
29CAMK1G1.27003900
30CSNK1G31.20859416
31PIK3CA1.19203570
32MAP2K41.18425916
33MAPK131.16917423
34WNK41.16332926
35SIK21.15794216
36STK391.11589903
37BMPR1B1.10752632
38DYRK1A1.07828581
39PINK11.07229394
40SGK4941.05010909
41SGK2231.05010909
42GSK3A1.04432231
43PRKCZ1.03009657
44CAMKK21.02041920
45CDC71.01318214
46PRKCG1.00927014
47ERBB31.00362530
48CSNK1G11.00278210
49CHEK20.99085963
50FER0.91681710
51CAMK40.91503867
52CAMK10.87821436
53PLK20.87666572
54MINK10.84136714
55STK40.82154451
56STK110.79727078
57DAPK20.76116001
58CDK50.75291677
59GRK10.73947992
60NEK90.72351510
61STK30.72280078
62PAK60.69255620
63MARK30.67460263
64NUAK10.67339781
65PNCK0.65677120
66SGK30.65662515
67SGK10.64237656
68CDK140.63592640
69TNIK0.62574643
70EIF2AK20.60863933
71PRKAA10.59587688
72CHUK0.55641741
73TNK20.55545191
74UHMK10.53561929
75ROCK10.51768019
76STK380.50361759
77ADRBK20.50344356
78CSNK1D0.50309272
79PRKG10.48196344
80OBSCN0.43819452
81PRKCE0.43584512
82PLK40.43338422
83PKN10.43009455
84EPHB10.42995600
85PHKG10.42840794
86PHKG20.42840794
87CDK150.41689265
88CDK90.41344006
89CDK180.40828633
90CSNK1E0.40028109
91RPS6KA10.39746402
92WEE10.38230580
93MKNK10.35216447
94CDK11A0.35147370
95CSNK1A10.34871349
96BCR0.34325932
97MAPK80.32809064
98INSRR0.32713832
99CHEK10.32629797
100MAP3K70.31984447

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043204.39409059
2Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.04810483
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.74006328
4Non-homologous end-joining_Homo sapiens_hsa034502.60164365
5Butanoate metabolism_Homo sapiens_hsa006502.50479553
6Fatty acid elongation_Homo sapiens_hsa000622.39409141
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.10865341
8Nicotine addiction_Homo sapiens_hsa050332.09554966
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01502492
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87948203
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80410267
12ABC transporters_Homo sapiens_hsa020101.72568168
13Axon guidance_Homo sapiens_hsa043601.68123603
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60311552
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.51318867
16Taste transduction_Homo sapiens_hsa047421.48610305
17Fatty acid metabolism_Homo sapiens_hsa012121.48369908
18Homologous recombination_Homo sapiens_hsa034401.46794363
19Dopaminergic synapse_Homo sapiens_hsa047281.46245084
20Insulin secretion_Homo sapiens_hsa049111.45432215
21Oxidative phosphorylation_Homo sapiens_hsa001901.43386759
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39444437
23Morphine addiction_Homo sapiens_hsa050321.37059323
24Peroxisome_Homo sapiens_hsa041461.36636384
25Tight junction_Homo sapiens_hsa045301.36426920
26Fanconi anemia pathway_Homo sapiens_hsa034601.35243324
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26268641
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16327258
29Parkinsons disease_Homo sapiens_hsa050121.15913744
30Cardiac muscle contraction_Homo sapiens_hsa042601.14163766
31Protein export_Homo sapiens_hsa030601.13946364
32Inositol phosphate metabolism_Homo sapiens_hsa005621.12576182
33Ether lipid metabolism_Homo sapiens_hsa005651.08966504
34Nitrogen metabolism_Homo sapiens_hsa009101.08802574
35Linoleic acid metabolism_Homo sapiens_hsa005911.07368082
36Huntingtons disease_Homo sapiens_hsa050161.07309433
37Alzheimers disease_Homo sapiens_hsa050101.00040654
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97525283
39Vitamin B6 metabolism_Homo sapiens_hsa007500.96345831
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93408508
41Serotonergic synapse_Homo sapiens_hsa047260.93116232
42Glutamatergic synapse_Homo sapiens_hsa047240.92112374
43GABAergic synapse_Homo sapiens_hsa047270.90930183
44Basal transcription factors_Homo sapiens_hsa030220.90033107
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.88699945
46Collecting duct acid secretion_Homo sapiens_hsa049660.87789479
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86956934
48Melanoma_Homo sapiens_hsa052180.84081259
49Salivary secretion_Homo sapiens_hsa049700.80493507
50Circadian entrainment_Homo sapiens_hsa047130.79040308
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77921547
52cAMP signaling pathway_Homo sapiens_hsa040240.76843017
53Tryptophan metabolism_Homo sapiens_hsa003800.76052687
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73572379
55RNA polymerase_Homo sapiens_hsa030200.70213716
56Synaptic vesicle cycle_Homo sapiens_hsa047210.69781046
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69434732
58Sulfur metabolism_Homo sapiens_hsa009200.68046975
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65593781
60Olfactory transduction_Homo sapiens_hsa047400.65525540
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62982004
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62633041
63Cocaine addiction_Homo sapiens_hsa050300.62217751
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62118224
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.60826486
66Phototransduction_Homo sapiens_hsa047440.59822650
67mRNA surveillance pathway_Homo sapiens_hsa030150.59028712
68Fatty acid degradation_Homo sapiens_hsa000710.58584564
69Long-term depression_Homo sapiens_hsa047300.58305553
70Endocytosis_Homo sapiens_hsa041440.57299828
71Glycerolipid metabolism_Homo sapiens_hsa005610.56996270
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.55904715
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55587324
74RNA degradation_Homo sapiens_hsa030180.55416818
75Calcium signaling pathway_Homo sapiens_hsa040200.53360329
76AMPK signaling pathway_Homo sapiens_hsa041520.52919230
77Cholinergic synapse_Homo sapiens_hsa047250.52828076
78Ras signaling pathway_Homo sapiens_hsa040140.52726622
79Lysine degradation_Homo sapiens_hsa003100.52003627
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50625799
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50332078
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49354425
83Chemical carcinogenesis_Homo sapiens_hsa052040.49313398
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47607592
85Glioma_Homo sapiens_hsa052140.47447269
86Oxytocin signaling pathway_Homo sapiens_hsa049210.46011963
87MicroRNAs in cancer_Homo sapiens_hsa052060.45085416
88Ovarian steroidogenesis_Homo sapiens_hsa049130.43946679
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43847663
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43693905
91Hippo signaling pathway_Homo sapiens_hsa043900.43466783
92RNA transport_Homo sapiens_hsa030130.42981123
93Metabolic pathways_Homo sapiens_hsa011000.42829215
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41673025
95Caffeine metabolism_Homo sapiens_hsa002320.39179245
96Alcoholism_Homo sapiens_hsa050340.39071623
97N-Glycan biosynthesis_Homo sapiens_hsa005100.37242174
98Folate biosynthesis_Homo sapiens_hsa007900.35211973
99Starch and sucrose metabolism_Homo sapiens_hsa005000.33825742
100ErbB signaling pathway_Homo sapiens_hsa040120.33653470

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