HMGB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.92262572
2spermatid development (GO:0007286)9.89281149
3reproduction (GO:0000003)9.70326234
4axonemal dynein complex assembly (GO:0070286)9.60291034
5motile cilium assembly (GO:0044458)9.22549981
6response to pheromone (GO:0019236)8.99829138
7cilium or flagellum-dependent cell motility (GO:0001539)8.64591007
8regulation of cilium movement (GO:0003352)8.46163156
9cilium movement (GO:0003341)8.00621739
10single fertilization (GO:0007338)7.56581138
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.38540434
12sperm capacitation (GO:0048240)7.37334114
13protein targeting to Golgi (GO:0000042)7.35645782
14negative regulation of inclusion body assembly (GO:0090084)7.18950958
15rRNA methylation (GO:0031167)7.16861397
16establishment of protein localization to Golgi (GO:0072600)7.06037204
17synaptonemal complex organization (GO:0070193)7.05449865
18male meiosis (GO:0007140)6.97600340
19synaptonemal complex assembly (GO:0007130)6.97072781
20retrograde transport, vesicle recycling within Golgi (GO:0000301)6.85395830
21spermatogenesis (GO:0007283)6.79736904
22male gamete generation (GO:0048232)6.77269949
23piRNA metabolic process (GO:0034587)6.59402277
24microtubule depolymerization (GO:0007019)6.59387321
25organic cation transport (GO:0015695)6.57521261
26fertilization (GO:0009566)6.36436987
27gamete generation (GO:0007276)6.22410263
28phosphatidylethanolamine biosynthetic process (GO:0006646)6.18016080
29rRNA modification (GO:0000154)6.02302937
30regulation of inclusion body assembly (GO:0090083)6.00629446
31centriole replication (GO:0007099)5.92811229
32calcium ion-dependent exocytosis (GO:0017156)5.70153173
33phosphatidylethanolamine metabolic process (GO:0046337)5.69820632
34spermatid nucleus differentiation (GO:0007289)5.57068342
35germ cell development (GO:0007281)5.45569621
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.41201461
37chromosome condensation (GO:0030261)5.32463487
38protein localization to Golgi apparatus (GO:0034067)5.30085987
39glycerol ether metabolic process (GO:0006662)5.29132988
40cellular ketone body metabolic process (GO:0046950)5.20190042
41cell recognition (GO:0008037)5.12755129
42positive regulation of Rab GTPase activity (GO:0032851)5.11182354
43regulation of Rab GTPase activity (GO:0032313)5.11182354
44ventricular system development (GO:0021591)5.09640066
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05161136
46DNA packaging (GO:0006323)5.01208695
47regulation of microtubule-based movement (GO:0060632)4.99307377
48regulation of centriole replication (GO:0046599)4.96329904
49multicellular organismal reproductive process (GO:0048609)4.90079040
50ether metabolic process (GO:0018904)4.89183496
51microtubule severing (GO:0051013)4.81818453
52chromosome organization involved in meiosis (GO:0070192)4.75094882
53sexual reproduction (GO:0019953)4.70672174
54seminiferous tubule development (GO:0072520)4.59813801
55ketone body metabolic process (GO:1902224)4.58551002
56male meiosis I (GO:0007141)4.57091755
57single strand break repair (GO:0000012)4.44327433
58regulation of transcription involved in cell fate commitment (GO:0060850)4.34844786
59DNA methylation involved in gamete generation (GO:0043046)4.29283121
60chaperone-mediated protein complex assembly (GO:0051131)4.16244944
61meiotic nuclear division (GO:0007126)4.09658591
62left/right pattern formation (GO:0060972)4.05460102
63musculoskeletal movement (GO:0050881)4.01511867
64multicellular organismal movement (GO:0050879)4.01511867
65glomerular visceral epithelial cell development (GO:0072015)3.99233514
66multicellular organismal development (GO:0007275)3.95755474
67sequestering of actin monomers (GO:0042989)3.83979940
68glomerular epithelial cell development (GO:0072310)3.80229736
69coenzyme catabolic process (GO:0009109)3.79157489
70negative regulation of Rho protein signal transduction (GO:0035024)3.76617132
71protein K11-linked deubiquitination (GO:0035871)3.67934890
72meiosis I (GO:0007127)3.62729364
73genitalia morphogenesis (GO:0035112)3.60544754
74microtubule nucleation (GO:0007020)3.58848368
75protein polyglutamylation (GO:0018095)3.48893136
76monoubiquitinated protein deubiquitination (GO:0035520)3.47885901
77microtubule polymerization or depolymerization (GO:0031109)3.39674048
78cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.39431565
79protein-DNA complex disassembly (GO:0032986)3.35058894
80nucleosome disassembly (GO:0006337)3.35058894
81glycolytic process (GO:0006096)3.28914674
82protein refolding (GO:0042026)3.28711499
83negative regulation of gene expression, epigenetic (GO:0045814)3.21764238
84regulation of spindle checkpoint (GO:0090231)3.21111415
85histone H3-K9 demethylation (GO:0033169)3.18767412
86regulation of interleukin-13 production (GO:0032656)3.18739041
87meiotic cell cycle (GO:0051321)3.13853389
88nucleoside diphosphate phosphorylation (GO:0006165)3.12124571
89membrane protein intracellular domain proteolysis (GO:0031293)3.11379139
90protein depolymerization (GO:0051261)3.10984534
91response to acidic pH (GO:0010447)3.10627687
92cerebral cortex neuron differentiation (GO:0021895)3.10280825
93nucleus organization (GO:0006997)3.09841842
94cellular response to pH (GO:0071467)3.05295650
95polyol catabolic process (GO:0046174)3.04826550
96regulation of T-helper 2 cell differentiation (GO:0045628)3.03906112
97mitotic sister chromatid cohesion (GO:0007064)3.02910543
98amino-acid betaine transport (GO:0015838)3.02176453
99carnitine transport (GO:0015879)3.02176453
100regulation of somitogenesis (GO:0014807)3.02100247
101protein localization to cilium (GO:0061512)3.02037050
102GTP biosynthetic process (GO:0006183)3.00835923
103homeostasis of number of cells within a tissue (GO:0048873)3.00829628
104DNA conformation change (GO:0071103)2.99309219
105positive regulation of macrophage activation (GO:0043032)2.97566581
106mesenchymal cell differentiation involved in renal system development (GO:2001012)2.97175061
107mesenchymal cell differentiation involved in kidney development (GO:0072161)2.97175061
108alditol metabolic process (GO:0019400)2.96184958
109peptidyl-threonine dephosphorylation (GO:0035970)2.94869122
110regulation of phosphoprotein phosphatase activity (GO:0043666)2.91372395
111receptor recycling (GO:0001881)2.86422669
112cranial nerve morphogenesis (GO:0021602)2.86144132
113interferon-gamma secretion (GO:0072643)2.85142246
114carnitine transmembrane transport (GO:1902603)2.84534201
115cell differentiation involved in metanephros development (GO:0072202)2.84219592
116synapsis (GO:0007129)2.78256974
117lactate metabolic process (GO:0006089)2.77269765
118polyamine biosynthetic process (GO:0006596)2.76143527
119cilium organization (GO:0044782)2.75543412
120chromatin silencing (GO:0006342)2.73471537
121mitotic G1 DNA damage checkpoint (GO:0031571)2.72992068
122intra-Golgi vesicle-mediated transport (GO:0006891)2.71377226
123meiotic cell cycle process (GO:1903046)2.69899710
124microtubule-based movement (GO:0007018)2.69121406
125detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.68787695
126UTP biosynthetic process (GO:0006228)2.68504440
127cellular component assembly involved in morphogenesis (GO:0010927)2.67312555
128RNA localization (GO:0006403)2.66759608
129cilium assembly (GO:0042384)2.64434825
130cilium morphogenesis (GO:0060271)2.60158736
131intraciliary transport (GO:0042073)2.59812734
132regulation of cilium assembly (GO:1902017)2.59567786
133RNA destabilization (GO:0050779)2.52829273
134axoneme assembly (GO:0035082)2.51756649
135glycerol metabolic process (GO:0006071)2.47450831
136negative regulation of organelle assembly (GO:1902116)2.46209665
137UTP metabolic process (GO:0046051)2.44379995
138centriole assembly (GO:0098534)2.39982078
139sperm motility (GO:0030317)14.3976261
140fusion of sperm to egg plasma membrane (GO:0007342)13.6348464
141cell wall macromolecule metabolic process (GO:0044036)13.6144395
142cell wall macromolecule catabolic process (GO:0016998)13.6144395
143acrosome reaction (GO:0007340)12.2997553
144acrosome assembly (GO:0001675)12.2219727
145sperm-egg recognition (GO:0035036)11.7947341
146multicellular organism reproduction (GO:0032504)11.1308453
147binding of sperm to zona pellucida (GO:0007339)10.7556565
148cell-cell recognition (GO:0009988)10.5649088
149plasma membrane fusion (GO:0045026)10.3913464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.09150085
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.46584595
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.29677462
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20598331
5EZH2_22144423_ChIP-Seq_EOC_Human4.00687935
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.66207370
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30191081
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91592021
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87946153
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55771339
11VDR_22108803_ChIP-Seq_LS180_Human2.54370512
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.18224711
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15486222
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.14317600
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13620047
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.08955712
17ZNF274_21170338_ChIP-Seq_K562_Hela2.08236598
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.05744854
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.04308441
20FUS_26573619_Chip-Seq_HEK293_Human2.02811082
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.98592165
22ERA_21632823_ChIP-Seq_H3396_Human1.96225875
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.92482441
24RAC3_21632823_ChIP-Seq_H3396_Human1.91141028
25DROSHA_22980978_ChIP-Seq_HELA_Human1.90582587
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90459307
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85301474
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84122829
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78496567
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76429896
31NANOG_20526341_ChIP-Seq_ESCs_Human1.75503990
32STAT1_17558387_ChIP-Seq_HELA_Human1.74475752
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.71914485
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.71434221
35CTCF_27219007_Chip-Seq_Bcells_Human1.70290873
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69538995
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69183173
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68651428
39* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66137442
40ER_23166858_ChIP-Seq_MCF-7_Human1.65520033
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64421069
42MYC_19829295_ChIP-Seq_ESCs_Human1.61983384
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.61046652
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59731560
45* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58279024
46GATA3_21867929_ChIP-Seq_CD8_Mouse1.57383658
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.56171666
48BCL6_27268052_Chip-Seq_Bcells_Human1.56087857
49KDM2B_26808549_Chip-Seq_REH_Human1.55922758
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.55353285
51SMC4_20622854_ChIP-Seq_HELA_Human1.52266376
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52242476
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.49131322
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.48937934
55E2F1_20622854_ChIP-Seq_HELA_Human1.48559516
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48398138
57* TAF2_19829295_ChIP-Seq_ESCs_Human1.46866939
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46733219
59TP53_18474530_ChIP-ChIP_U2OS_Human1.44330923
60CTCF_20526341_ChIP-Seq_ESCs_Human1.44209604
61BCOR_27268052_Chip-Seq_Bcells_Human1.44151744
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43549196
63TP63_22573176_ChIP-Seq_HFKS_Human1.43435017
64P68_20966046_ChIP-Seq_HELA_Human1.43030321
65AR_25329375_ChIP-Seq_VCAP_Human1.42952443
66CBP_20019798_ChIP-Seq_JUKART_Human1.42721599
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42721599
68OCT4_20526341_ChIP-Seq_ESCs_Human1.41706949
69PHF8_20622854_ChIP-Seq_HELA_Human1.41558384
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38570327
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37910363
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.37136972
73LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35128950
74FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34965604
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34961393
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34766391
77* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34049198
78P53_21459846_ChIP-Seq_SAOS-2_Human1.33847469
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.32921937
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.32289052
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32152874
82* HNFA_21074721_ChIP-Seq_CACO-2_Human1.32004188
83P300_19829295_ChIP-Seq_ESCs_Human1.30460754
84* RBPJ_21746931_ChIP-Seq_IB4_Human1.28840995
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.28356374
86* REST_21632747_ChIP-Seq_MESCs_Mouse1.27513804
87CEBPB_22108803_ChIP-Seq_LS180_Human1.27123658
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27118157
89P300_27268052_Chip-Seq_Bcells_Human1.26684801
90LXR_22292898_ChIP-Seq_THP-1_Human1.26543511
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.26366786
92* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25749717
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.25246727
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24193743
95* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23756888
96* ETV1_20927104_ChIP-Seq_GIST48_Human1.23718156
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23630714
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23559313
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23216498
100GF1_26923725_Chip-Seq_HPCs_Mouse1.22719135
101* SMAD3_21741376_ChIP-Seq_ESCs_Human1.22541567
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22302860
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21981856
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21333163
105TAF15_26573619_Chip-Seq_HEK293_Human1.19125452
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18860585
107P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18342048
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17597971
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17597971
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17029054
111CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16342583
112* NFYB_21822215_ChIP-Seq_K562_Human1.15355545
113* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14528522
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14442354
115RUNX_20019798_ChIP-Seq_JUKART_Human1.14097240
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.13474243
117* TBL1_22424771_ChIP-Seq_293T_Human1.13292077
118SPI1_26923725_Chip-Seq_HPCs_Mouse1.13075386
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12742273
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12389396
121* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12205388
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11002718
123RUNX2_22187159_ChIP-Seq_PCA_Human1.10451808
124SA1_27219007_Chip-Seq_Bcells_Human1.09716390
125ERG_20517297_ChIP-Seq_VCAP_Human1.09149235
126* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08840625
127SMRT_27268052_Chip-Seq_Bcells_Human1.08194592
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07047165
129ESET_19884257_ChIP-Seq_ESCs_Mouse1.06989340
130RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06771587
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.05630163
132* SMAD4_21741376_ChIP-Seq_HESCs_Human1.05353140
133* PHF8_20622853_ChIP-Seq_HELA_Human1.05159488
134* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04806281
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.04711317
136ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04551651
137* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04125506
138P53_22387025_ChIP-Seq_ESCs_Mouse1.03867634
139RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02991006
140STAT3_23295773_ChIP-Seq_U87_Human1.02354084
141NANOG_19829295_ChIP-Seq_ESCs_Human1.02214339
142SOX2_19829295_ChIP-Seq_ESCs_Human1.02214339
143HOXB7_26014856_ChIP-Seq_BT474_Human1.01995897
144GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01988460
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01904121
146* GATA6_21074721_ChIP-Seq_CACO-2_Human1.01827930
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01773886
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00923120
149CMYC_18555785_Chip-Seq_ESCs_Mouse1.00898209
150AR_21572438_ChIP-Seq_LNCaP_Human1.00212131
151RNF2_27304074_Chip-Seq_NSC_Mouse0.99891724
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99775938
153RARA_24833708_ChIP-Seq_LIVER_Mouse0.98854335
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98779721
155OCT1_27270436_Chip-Seq_PROSTATE_Human0.98595736
156* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97296849
157* MYC_27129775_Chip-Seq_CORNEA_Mouse0.96818622
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.96785093
159P300_18555785_Chip-Seq_ESCs_Mouse0.96075884
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.95202372
161LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95112012
162* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94594173
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94175750
164SOX9_26525672_Chip-Seq_HEART_Mouse0.93419063
165KLF4_18555785_Chip-Seq_ESCs_Mouse0.93318146
166SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91794628
167* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91769060
168KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91687701
169SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91244461
170PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91058352
171FLI1_21867929_ChIP-Seq_CD8_Mouse0.90648591
172ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90495352
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.90116585
174GF1B_26923725_Chip-Seq_HPCs_Mouse0.89459814
175* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89283517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.12424228
2MP0001929_abnormal_gametogenesis5.59129946
3MP0008877_abnormal_DNA_methylation3.96229079
4MP0002210_abnormal_sex_determination3.35340311
5MP0002161_abnormal_fertility/fecundity3.33580375
6MP0005670_abnormal_white_adipose2.91742430
7MP0001145_abnormal_male_reproductive2.84192069
8MP0000678_abnormal_parathyroid_gland2.48430785
9MP0000653_abnormal_sex_gland2.45793940
10MP0003718_maternal_effect2.17007636
11MP0002653_abnormal_ependyma_morphology2.15861049
12MP0005410_abnormal_fertilization16.7213557
13MP0002132_abnormal_respiratory_system1.95717883
14MP0005379_endocrine/exocrine_gland_phen1.93575767
15MP0001485_abnormal_pinna_reflex1.72085086
16MP0005423_abnormal_somatic_nervous1.66257866
17MP0001486_abnormal_startle_reflex1.64055170
18MP0005310_abnormal_salivary_gland1.55515709
19MP0002249_abnormal_larynx_morphology1.53692100
20MP0002160_abnormal_reproductive_system1.53033086
21MP0005623_abnormal_meninges_morphology1.39277296
22MP0004510_myositis1.38501434
23MP0004233_abnormal_muscle_weight1.37239761
24MP0009053_abnormal_anal_canal1.36104587
25MP0003646_muscle_fatigue1.34048632
26MP0005451_abnormal_body_composition1.33223569
27MP0005248_abnormal_Harderian_gland1.21546894
28MP0001765_abnormal_ion_homeostasis1.20169439
29MP0002282_abnormal_trachea_morphology1.19369148
30MP0004859_abnormal_synaptic_plasticity1.18586057
31MP0001963_abnormal_hearing_physiology1.14239722
32MP0002138_abnormal_hepatobiliary_system1.14044992
33MP0002735_abnormal_chemical_nociception1.12379875
34MP0002127_abnormal_cardiovascular_syste1.10401330
35MP0001984_abnormal_olfaction1.02100287
36MP0005395_other_phenotype1.01259844
37MP0000026_abnormal_inner_ear1.00060802
38MP0005647_abnormal_sex_gland0.96056641
39MP0002234_abnormal_pharynx_morphology0.88859316
40MP0002822_catalepsy0.88638555
41MP0008058_abnormal_DNA_repair0.88601257
42MP0009046_muscle_twitch0.86415903
43MP0000955_abnormal_spinal_cord0.83583577
44MP0000681_abnormal_thyroid_gland0.80819278
45MP0002067_abnormal_sensory_capabilities0.75809208
46MP0005389_reproductive_system_phenotype0.74691944
47MP0000049_abnormal_middle_ear0.73768560
48MP0008995_early_reproductive_senescence0.73625774
49MP0004085_abnormal_heartbeat0.72742956
50MP0002733_abnormal_thermal_nociception0.71969704
51MP0001879_abnormal_lymphatic_vessel0.69608882
52MP0005167_abnormal_blood-brain_barrier0.68354833
53MP0002557_abnormal_social/conspecific_i0.67468462
54MP0005636_abnormal_mineral_homeostasis0.67305373
55MP0005367_renal/urinary_system_phenotyp0.67181064
56MP0000516_abnormal_urinary_system0.67181064
57MP0003011_delayed_dark_adaptation0.63944910
58MP0003115_abnormal_respiratory_system0.62832280
59MP0005083_abnormal_biliary_tract0.61500652
60MP0009697_abnormal_copulation0.61387815
61MP0002572_abnormal_emotion/affect_behav0.57503400
62MP0005666_abnormal_adipose_tissue0.56844982
63MP0004036_abnormal_muscle_relaxation0.56606283
64MP0003878_abnormal_ear_physiology0.56391088
65MP0005377_hearing/vestibular/ear_phenot0.56391088
66MP0002736_abnormal_nociception_after0.55807909
67MP0001666_abnormal_nutrient_absorption0.54522623
68MP0004484_altered_response_of0.53592427
69MP0000003_abnormal_adipose_tissue0.52660259
70MP0001764_abnormal_homeostasis0.52484868
71MP0001905_abnormal_dopamine_level0.51923835
72MP0003329_amyloid_beta_deposits0.50854901
73MP0001324_abnormal_eye_pigmentation0.50492579
74MP0003137_abnormal_impulse_conducting0.49373852
75MP0002272_abnormal_nervous_system0.49280204
76MP0001970_abnormal_pain_threshold0.48435025
77MP0009745_abnormal_behavioral_response0.48007402
78MP0002734_abnormal_mechanical_nocicepti0.47025756
79MP0005535_abnormal_body_temperature0.46924865
80MP0000569_abnormal_digit_pigmentation0.46799625
81MP0003699_abnormal_female_reproductive0.45984338
82MP0001501_abnormal_sleep_pattern0.45923690
83MP0003077_abnormal_cell_cycle0.45781113
84MP0001440_abnormal_grooming_behavior0.45497356
85MP0002269_muscular_atrophy0.44172002
86MP0000358_abnormal_cell_content/0.43682662
87MP0000230_abnormal_systemic_arterial0.42419469
88MP0003119_abnormal_digestive_system0.41486024
89MP0001293_anophthalmia0.40824714
90MP0010094_abnormal_chromosome_stability0.40739783
91MP0005253_abnormal_eye_physiology0.40271271
92MP0000249_abnormal_blood_vessel0.40162476
93MP0005551_abnormal_eye_electrophysiolog0.39627137
94MP0001545_abnormal_hematopoietic_system0.39199438
95MP0005397_hematopoietic_system_phenotyp0.39199438
96MP0008961_abnormal_basal_metabolism0.39196192
97MP0002928_abnormal_bile_duct0.38969382
98MP0006292_abnormal_olfactory_placode0.38821228
99MP0006036_abnormal_mitochondrial_physio0.38722069
100MP0000470_abnormal_stomach_morphology0.36624568
101MP0009115_abnormal_fat_cell0.34986603
102MP0003936_abnormal_reproductive_system0.34523304
103MP0000534_abnormal_ureter_morphology0.34486778
104MP0005084_abnormal_gallbladder_morpholo0.34411281
105MP0003950_abnormal_plasma_membrane0.34175282
106MP0000613_abnormal_salivary_gland0.34035612
107MP0005408_hypopigmentation0.33698085
108MP0000566_synostosis0.33290957
109MP0001968_abnormal_touch/_nociception0.33080747
110MP0003635_abnormal_synaptic_transmissio0.32573645
111MP0009278_abnormal_bone_marrow0.31517503
112MP0002139_abnormal_hepatobiliary_system0.31003990
113MP0003633_abnormal_nervous_system0.30265777
114MP0004133_heterotaxia0.30119274
115MP0002971_abnormal_brown_adipose0.28588229
116MP0005391_vision/eye_phenotype0.28525134
117MP0003879_abnormal_hair_cell0.28135448
118MP0004019_abnormal_vitamin_homeostasis0.27946634
119MP0004811_abnormal_neuron_physiology0.27569616
120MP0002102_abnormal_ear_morphology0.26977967
121MP0001119_abnormal_female_reproductive0.26908497
122MP0000604_amyloidosis0.25961365
123MP0003786_premature_aging0.23537776
124MP0002169_no_abnormal_phenotype0.23028369
125MP0003631_nervous_system_phenotype0.22935556
126MP0002873_normal_phenotype0.22833474
127MP0003942_abnormal_urinary_system0.22263795
128MP0003948_abnormal_gas_homeostasis0.21322512
129MP0003861_abnormal_nervous_system0.21045663
130MP0004270_analgesia0.20982969
131MP0008057_abnormal_DNA_replication0.20917558
132MP0003111_abnormal_nucleus_morphology0.20192689
133MP0001730_embryonic_growth_arrest0.20130269
134MP0002152_abnormal_brain_morphology0.19938997
135MP0001727_abnormal_embryo_implantation0.19604667
136MP0004742_abnormal_vestibular_system0.19442104
137MP0004145_abnormal_muscle_electrophysio0.19229324
138MP0006035_abnormal_mitochondrial_morpho0.17988160
139MP0001348_abnormal_lacrimal_gland0.16989537
140MP0002295_abnormal_pulmonary_circulatio0.16895802
141MP0010307_abnormal_tumor_latency0.16523894
142MP0005375_adipose_tissue_phenotype0.16170036
143MP0008569_lethality_at_weaning0.15576731
144MP0001849_ear_inflammation0.15473886
145MP0005319_abnormal_enzyme/_coenzyme0.15134351
146MP0004043_abnormal_pH_regulation0.14892646
147MP0008875_abnormal_xenobiotic_pharmacok0.14822959
148MP0008007_abnormal_cellular_replicative0.14779469
149MP0002229_neurodegeneration0.14485912
150MP0002693_abnormal_pancreas_physiology0.14107312
151MP0000001_mammalian_phenotype0.13995936
152MP0000751_myopathy0.13505575
153MP0005365_abnormal_bile_salt0.12252596
154MP0002092_abnormal_eye_morphology0.12028710
155MP0000313_abnormal_cell_death0.11624388
156MP0004084_abnormal_cardiac_muscle0.11219636
157MP0000462_abnormal_digestive_system0.11166471
158MP0002405_respiratory_system_inflammati0.11065887
159MP0005195_abnormal_posterior_eye0.10646302
160MP0002118_abnormal_lipid_homeostasis0.10598998

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.51460207
2Abnormal respiratory motile cilium morphology (HP:0005938)9.37241781
3Abnormal respiratory epithelium morphology (HP:0012253)9.37241781
4Severe visual impairment (HP:0001141)8.06615482
5Abnormal ciliary motility (HP:0012262)7.66236300
6Chronic bronchitis (HP:0004469)7.45994283
7Rhinitis (HP:0012384)7.43760481
8Infertility (HP:0000789)6.91561887
9Nasal polyposis (HP:0100582)6.34957123
10Abnormality of the nasal mucosa (HP:0000433)5.21906522
11Chronic hepatic failure (HP:0100626)4.99762953
12Attenuation of retinal blood vessels (HP:0007843)4.96338567
13Male infertility (HP:0003251)4.86830656
14Bony spicule pigmentary retinopathy (HP:0007737)4.83774859
15Resting tremor (HP:0002322)4.67400260
16Bronchitis (HP:0012387)4.55616653
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.44483047
18Bronchiectasis (HP:0002110)4.35484749
19Hyperkalemia (HP:0002153)4.27469841
20Abnormality of macular pigmentation (HP:0008002)4.10176717
21Cone-rod dystrophy (HP:0000548)4.03971295
22Nephronophthisis (HP:0000090)4.02611092
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.77802436
24Potter facies (HP:0002009)3.76394901
25Facial shape deformation (HP:0011334)3.76394901
26Abnormal rod and cone electroretinograms (HP:0008323)3.69931494
27Abnormal spermatogenesis (HP:0008669)3.66624663
28Hypoplastic ischia (HP:0003175)3.64639642
29Recurrent sinusitis (HP:0011108)3.51309408
30Enlarged epiphyses (HP:0010580)3.48588644
31Hypoplasia of the thymus (HP:0000778)3.30240426
32Abnormality of the ischium (HP:0003174)3.26735560
33Recurrent otitis media (HP:0000403)3.26547484
34Progressive sensorineural hearing impairment (HP:0000408)3.18516779
35Hypoalphalipoproteinemia (HP:0003233)3.10689225
36Postural instability (HP:0002172)3.10396854
37Amelogenesis imperfecta (HP:0000705)3.04084506
38Abnormality of the renal medulla (HP:0100957)3.02798528
39Progressive cerebellar ataxia (HP:0002073)2.90198767
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.89878175
41Unilateral renal agenesis (HP:0000122)2.87201768
42Abnormality of dental color (HP:0011073)2.80788964
43Truncal obesity (HP:0001956)2.79426984
44Tubulointerstitial nephritis (HP:0001970)2.79036211
45Menstrual irregularities (HP:0000858)2.70912781
46Abnormality of the aortic arch (HP:0012303)2.66950654
47Renovascular hypertension (HP:0100817)2.64577874
48Recurrent bronchitis (HP:0002837)2.62031566
49Portal hypertension (HP:0001409)2.58194277
50Abnormality of midbrain morphology (HP:0002418)2.56852635
51Molar tooth sign on MRI (HP:0002419)2.56852635
52Tubular atrophy (HP:0000092)2.56654572
53Insulin-resistant diabetes mellitus (HP:0000831)2.52157483
54Abnormality of the costochondral junction (HP:0000919)2.48126732
55Generalized aminoaciduria (HP:0002909)2.47925551
56Abnormality of potassium homeostasis (HP:0011042)2.46961642
57Medial flaring of the eyebrow (HP:0010747)2.45190236
58Impulsivity (HP:0100710)2.39311365
59Tubulointerstitial abnormality (HP:0001969)2.39171681
60Abnormality of the hepatic vasculature (HP:0006707)2.36153716
61Ventricular tachycardia (HP:0004756)2.35307196
62Azoospermia (HP:0000027)2.27611663
63Abnormal gallbladder physiology (HP:0012438)2.24296685
64Cholecystitis (HP:0001082)2.24296685
65Focal segmental glomerulosclerosis (HP:0000097)2.23038337
66Gonadotropin excess (HP:0000837)2.20252693
67Polyuria (HP:0000103)2.18660560
68Dyschromatopsia (HP:0007641)2.16221237
69Abnormality of the parathyroid morphology (HP:0011766)2.13823322
70Osteomalacia (HP:0002749)2.13804696
71Flattened epiphyses (HP:0003071)2.11609091
72Intellectual disability, moderate (HP:0002342)2.06230189
73Increased purine levels (HP:0004368)2.05275289
74Hyperuricemia (HP:0002149)2.05275289
75Progressive hearing impairment (HP:0001730)2.04052897
76Epiphyseal dysplasia (HP:0002656)2.01633335
77Absent/shortened dynein arms (HP:0200106)13.7296787
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.7296787
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1624655
80Widely patent fontanelles and sutures (HP:0004492)1.99186761
81Hyponatremia (HP:0002902)1.98176705
82Decreased central vision (HP:0007663)1.94780298
83Tubulointerstitial fibrosis (HP:0005576)1.93504579
84Abnormality of the epiphysis of the femoral head (HP:0010574)1.91613280
85Hypophosphatemic rickets (HP:0004912)1.91256429
86Bradycardia (HP:0001662)1.90592302
87Myokymia (HP:0002411)1.90481698
88Recurrent pneumonia (HP:0006532)1.89414479
89Abnormality of the pubic bones (HP:0003172)1.84379356
90Choroideremia (HP:0001139)1.83536117
91Optic nerve hypoplasia (HP:0000609)1.83171075
92Recurrent corneal erosions (HP:0000495)1.81378904
93Tetany (HP:0001281)1.79489702
94Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78400216
95Abnormality of femoral epiphyses (HP:0006499)1.78400216
96Flat capital femoral epiphysis (HP:0003370)1.77901116
97Subcapsular cataract (HP:0000523)1.77369832
98Spastic tetraparesis (HP:0001285)1.75943873
99Glomerulosclerosis (HP:0000096)1.75721568
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74970779
101Postaxial foot polydactyly (HP:0001830)1.74011644
102Polydipsia (HP:0001959)1.73679140
103Abnormal drinking behavior (HP:0030082)1.73679140
104Spastic paraparesis (HP:0002313)1.72259936
105Stage 5 chronic kidney disease (HP:0003774)1.72202799
106Abnormal ventriculo-arterial connection (HP:0011563)1.70826907
107Abnormal connection of the cardiac segments (HP:0011545)1.70826907
108Congenital malformation of the right heart (HP:0011723)1.70359908
109Double outlet right ventricle (HP:0001719)1.70359908
110Abnormality of renal excretion (HP:0011036)1.66693890
111Congenital hepatic fibrosis (HP:0002612)1.65486170
112Asymmetric septal hypertrophy (HP:0001670)1.64213896
113Abnormal biliary tract physiology (HP:0012439)1.63650427
114Bile duct proliferation (HP:0001408)1.63650427
115Abnormality of the renal cortex (HP:0011035)1.63559869
116Hemorrhage of the eye (HP:0011885)1.62054331
117Heterotopia (HP:0002282)1.56430443
118Abnormality of permanent molar morphology (HP:0011071)1.51670772
119Abnormality of the dental root (HP:0006486)1.51670772
120Taurodontia (HP:0000679)1.51670772
121Oculomotor apraxia (HP:0000657)1.48076407
122Aplasia/Hypoplasia of the lens (HP:0008063)1.47997988
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.47629876
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.47141858
125Bell-shaped thorax (HP:0001591)1.46545892
126Short ribs (HP:0000773)1.46487403
127Fibular hypoplasia (HP:0003038)1.45094170
128Neurofibrillary tangles (HP:0002185)1.44656296
129Abnormality of the dental pulp (HP:0006479)1.41271376
130Abnormality of molar (HP:0011077)1.40263389
131Abnormality of molar morphology (HP:0011070)1.40263389
132Postaxial hand polydactyly (HP:0001162)1.40048038
133Bundle branch block (HP:0011710)1.39958919
134Abnormality of dentin (HP:0010299)1.38504758
135Cystic liver disease (HP:0006706)1.37470922
136Abnormality of the lower motor neuron (HP:0002366)1.37194624
137Abnormal urine output (HP:0012590)1.35584620
138Renal dysplasia (HP:0000110)1.34619193
139Constricted visual fields (HP:0001133)1.33156290
140Facial cleft (HP:0002006)1.32869114
141Chronic sinusitis (HP:0011109)1.32059973
142Congenital primary aphakia (HP:0007707)1.32031441
143Exercise-induced myalgia (HP:0003738)1.32007497
144Gait imbalance (HP:0002141)1.32004794
145Deformed sella turcica (HP:0002681)1.31332263
146Pancreatic fibrosis (HP:0100732)1.29772068
147Easy fatigability (HP:0003388)1.29418930
148Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.26316570
149Fatigable weakness (HP:0003473)1.23001735
150Abnormality of the neuromuscular junction (HP:0003398)1.23001735
151Sensory axonal neuropathy (HP:0003390)1.21297248
152Myoglobinuria (HP:0002913)1.21215076
153Amyotrophic lateral sclerosis (HP:0007354)1.18987426
154Absent frontal sinuses (HP:0002688)1.18935692
155Cerebral inclusion bodies (HP:0100314)1.17289118
156J-shaped sella turcica (HP:0002680)1.16341819
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.16127095
158Abnormality of saccadic eye movements (HP:0000570)1.15851911
159Absent epiphyses (HP:0010577)1.15245028
160Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.15245028
161Cerebellar dysplasia (HP:0007033)1.14995927
162Microglossia (HP:0000171)1.14898984
163Vascular calcification (HP:0004934)1.13740242
164Nephropathy (HP:0000112)1.12937847
165Broad distal phalanx of finger (HP:0009836)1.12428328
166True hermaphroditism (HP:0010459)1.12215651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.61328831
2PDK48.61328831
3TESK15.79505400
4PDK25.60860975
5PRKD34.64402907
6DDR24.38223675
7INSRR4.27068900
8ICK4.21927916
9BRD43.62370214
10PLK23.45964592
11MAP4K23.27459553
12PTK2B2.20818103
13WNK42.12327794
14PIK3CG2.06414025
15STK392.04415038
16PNCK1.75225482
17STK381.68561545
18DYRK1B1.59948031
19MST1R1.53641945
20NEK21.43054305
21CDK121.37935748
22PDK11.26746305
23CDK71.20097705
24MAP3K90.98217961
25KSR20.97044249
26CAMK1D0.93512020
27LATS20.89612654
28DYRK30.87676108
29TYRO30.86639671
30AKT30.82090362
31IRAK10.81497970
32WNK10.78898667
33SIK20.78834787
34PDPK10.78103450
35MAPK150.75898029
36MAP3K110.71308303
37RIPK40.70964653
38CCNB10.66842430
39PASK0.64453217
40PRKAA20.64247563
41UHMK10.63490203
42TIE10.61989962
43MAP2K60.61771775
44RPS6KA20.61571104
45LMTK20.58850730
46TTK0.56981277
47CAMK10.56841894
48STK30.55998508
49TESK20.55930771
50LATS10.55757211
51EEF2K0.55379535
52MAP2K20.54721628
53CHEK20.54358067
54PINK10.52847063
55MAP3K20.52346265
56CDK30.50764743
57CAMK1G0.47653380
58SGK4940.47331663
59SGK2230.47331663
60BMPR1B0.46737947
61ROCK10.46013600
62MAP3K80.45681693
63STK38L0.44888475
64IRAK20.43685215
65MUSK0.41583118
66NTRK20.40531578
67MAPK10.39784603
68PAK10.38645297
69PRKCG0.37287913
70CHEK10.36755593
71CAMK40.36579917
72NTRK30.34856933
73MAP3K10.32406222
74MAP3K100.32217808
75CDK40.31162206
76FRK0.30277826
77RPS6KC10.29218816
78RPS6KL10.29218816
79SGK10.28463954
80RPS6KA60.27562502
81MAPKAPK50.25808195
82PAK20.25401644
83ARAF0.25150655
84ATM0.25138033
85CAMKK10.24016718
86PLK40.23714628
87BRSK20.22235859
88NEK60.21622446
89MAPK140.21610244
90MARK20.21446963
91TLK10.20985275
92ATR0.20092093
93MTOR0.19745495
94MAPK100.19535016
95PRKCZ0.19393975
96WEE10.19125294
97MAPK110.17983091
98PAK40.17959784
99SGK20.17828572
100MET0.17239322
101AKT10.16733809
102BLK0.16276581
103PRKAA10.15900491
104CDK150.15787615
105PRKCQ0.15778411
106PRKG20.15438735
107RPS6KB10.15099896
108CDK180.13297868
109TNIK0.12727461
110CDK11A0.11816686
111BRSK10.11571185
112FER0.10969212
113PLK10.10529718
114OXSR10.10458975
115CDC70.09681905
116JAK30.08938113
117MARK30.08500860
118CDK140.08479416
119BRAF0.07866894
120ADRBK20.07830149
121CSNK2A10.07506333
122GSK3B0.06666050
123RPS6KA10.06628015
124CHUK0.06142496
125MAPK90.05879055
126SGK30.05589231
127PRKG10.05410514
128PRKACG0.05131532
129PKN10.05116412
130STK100.04462243
131PRKCD0.04064343
132CSNK1D0.03200613
133CAMK2A0.03186863
134MAPK80.02962860
135PIM10.02763924
136CDK10.02618192
137STK110.02385676
138CSNK2A20.02273034
139CSF1R0.02227549
140PRKCB0.02107737
141CDK20.01770914
142PRKCA0.01480642
143WNK30.01404996
144CDK60.01169935
145MAP3K40.00821157
146MARK1-0.0373669
147PRKDC-0.0355293
148CLK1-0.0351987
149PDGFRB-0.0341486
150MAP3K5-0.0285507
151PRKACB-0.0228791
152MAP2K7-0.0226536
153AURKA-0.0221702
154RPS6KA3-0.0201846
155PRKACA-0.0193429
156ZAP70-0.0129439
157EGFR-0.0126452

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.52167225
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.63174786
3Fatty acid biosynthesis_Homo sapiens_hsa000614.57579522
4Olfactory transduction_Homo sapiens_hsa047403.91556666
5Vitamin B6 metabolism_Homo sapiens_hsa007503.77750001
6Pyruvate metabolism_Homo sapiens_hsa006203.62009028
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.04451469
8Linoleic acid metabolism_Homo sapiens_hsa005912.94773737
9Propanoate metabolism_Homo sapiens_hsa006402.82798202
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.78801443
11Glucagon signaling pathway_Homo sapiens_hsa049222.63235381
12Butanoate metabolism_Homo sapiens_hsa006502.54101520
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.28281640
14Basal transcription factors_Homo sapiens_hsa030222.20647364
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05288160
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.04259842
17Glycerolipid metabolism_Homo sapiens_hsa005611.91963032
18Selenocompound metabolism_Homo sapiens_hsa004501.87498905
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.87159094
20PPAR signaling pathway_Homo sapiens_hsa033201.86607516
21Type I diabetes mellitus_Homo sapiens_hsa049401.84874531
22Allograft rejection_Homo sapiens_hsa053301.82340388
23Autoimmune thyroid disease_Homo sapiens_hsa053201.77525269
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.75199735
25Pentose phosphate pathway_Homo sapiens_hsa000301.74265731
26Graft-versus-host disease_Homo sapiens_hsa053321.68025392
27Type II diabetes mellitus_Homo sapiens_hsa049301.62311298
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.62148650
29Oocyte meiosis_Homo sapiens_hsa041141.60059999
30Fructose and mannose metabolism_Homo sapiens_hsa000511.58044908
31Phenylalanine metabolism_Homo sapiens_hsa003601.56513165
32Mineral absorption_Homo sapiens_hsa049781.56207172
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51890883
34Amphetamine addiction_Homo sapiens_hsa050311.49879399
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46749907
36Fat digestion and absorption_Homo sapiens_hsa049751.43544925
37Carbon metabolism_Homo sapiens_hsa012001.42335796
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38759630
39Ether lipid metabolism_Homo sapiens_hsa005651.37540299
40Fatty acid degradation_Homo sapiens_hsa000711.37082134
41Fatty acid metabolism_Homo sapiens_hsa012121.36655628
42Cardiac muscle contraction_Homo sapiens_hsa042601.30818431
43Viral myocarditis_Homo sapiens_hsa054161.30357237
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.24425639
45Dorso-ventral axis formation_Homo sapiens_hsa043201.21923963
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18817342
47Arginine and proline metabolism_Homo sapiens_hsa003301.15831928
48Phototransduction_Homo sapiens_hsa047441.15082864
49Renin secretion_Homo sapiens_hsa049241.12526443
50Fanconi anemia pathway_Homo sapiens_hsa034601.11583634
51Antigen processing and presentation_Homo sapiens_hsa046121.06775500
52Collecting duct acid secretion_Homo sapiens_hsa049661.04601364
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03932484
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02834237
55Purine metabolism_Homo sapiens_hsa002301.00112052
56Glutathione metabolism_Homo sapiens_hsa004800.97786023
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97647548
58Arginine biosynthesis_Homo sapiens_hsa002200.94793057
59Biosynthesis of amino acids_Homo sapiens_hsa012300.94569244
60Huntingtons disease_Homo sapiens_hsa050160.91738056
61Morphine addiction_Homo sapiens_hsa050320.87866033
62mRNA surveillance pathway_Homo sapiens_hsa030150.85963336
63Influenza A_Homo sapiens_hsa051640.85273173
64Insulin secretion_Homo sapiens_hsa049110.83698352
65Chemical carcinogenesis_Homo sapiens_hsa052040.83379155
66Arachidonic acid metabolism_Homo sapiens_hsa005900.80639279
67Hedgehog signaling pathway_Homo sapiens_hsa043400.80616926
68Nicotine addiction_Homo sapiens_hsa050330.77074868
69Thyroid hormone synthesis_Homo sapiens_hsa049180.76433329
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.74929511
71Bile secretion_Homo sapiens_hsa049760.74730909
72Long-term potentiation_Homo sapiens_hsa047200.74501593
73Renin-angiotensin system_Homo sapiens_hsa046140.69437385
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69436256
75Estrogen signaling pathway_Homo sapiens_hsa049150.68804750
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.66061544
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65506784
78RNA transport_Homo sapiens_hsa030130.65416749
79Tyrosine metabolism_Homo sapiens_hsa003500.64257996
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59791679
81Legionellosis_Homo sapiens_hsa051340.59053835
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56147092
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.56097492
84Pancreatic secretion_Homo sapiens_hsa049720.55999033
85Salivary secretion_Homo sapiens_hsa049700.54920105
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54051976
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52785608
88Calcium signaling pathway_Homo sapiens_hsa040200.52611233
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.52004784
90Synaptic vesicle cycle_Homo sapiens_hsa047210.51543290
91MAPK signaling pathway_Homo sapiens_hsa040100.50134560
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49137754
93Sulfur metabolism_Homo sapiens_hsa009200.49084450
94Protein digestion and absorption_Homo sapiens_hsa049740.48641994
95Serotonergic synapse_Homo sapiens_hsa047260.48233525
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46553710
97ABC transporters_Homo sapiens_hsa020100.43757301
98Gastric acid secretion_Homo sapiens_hsa049710.42926517
99Nitrogen metabolism_Homo sapiens_hsa009100.41758869
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.41735436
101Systemic lupus erythematosus_Homo sapiens_hsa053220.41570311
102Endocytosis_Homo sapiens_hsa041440.41078182
103Acute myeloid leukemia_Homo sapiens_hsa052210.40817821
104Inositol phosphate metabolism_Homo sapiens_hsa005620.40608157
105Metabolic pathways_Homo sapiens_hsa011000.39295627
106Cholinergic synapse_Homo sapiens_hsa047250.38987042
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38732307
108AMPK signaling pathway_Homo sapiens_hsa041520.38583118
109Tight junction_Homo sapiens_hsa045300.36981225
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36791380
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36136956
112VEGF signaling pathway_Homo sapiens_hsa043700.35652770
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35511966
114GABAergic synapse_Homo sapiens_hsa047270.32759630
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32672695
116Oxytocin signaling pathway_Homo sapiens_hsa049210.32656915
117Taste transduction_Homo sapiens_hsa047420.31064974
118cAMP signaling pathway_Homo sapiens_hsa040240.30533573
119ECM-receptor interaction_Homo sapiens_hsa045120.29207810
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28852359
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.28418188
122Circadian entrainment_Homo sapiens_hsa047130.25675320
123Pyrimidine metabolism_Homo sapiens_hsa002400.22514522
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22471390
125Herpes simplex infection_Homo sapiens_hsa051680.22126800
126Viral carcinogenesis_Homo sapiens_hsa052030.20842600
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20223420
128Prolactin signaling pathway_Homo sapiens_hsa049170.18487132
129Cocaine addiction_Homo sapiens_hsa050300.17918984
130Alcoholism_Homo sapiens_hsa050340.16782424
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16735110
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.15554089
133B cell receptor signaling pathway_Homo sapiens_hsa046620.13025726
134Wnt signaling pathway_Homo sapiens_hsa043100.09986691
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08959966
136Salmonella infection_Homo sapiens_hsa051320.08928434
137Retinol metabolism_Homo sapiens_hsa008300.07234924
138HIF-1 signaling pathway_Homo sapiens_hsa040660.07055389
139Glutamatergic synapse_Homo sapiens_hsa047240.06345225
140N-Glycan biosynthesis_Homo sapiens_hsa005100.04853731

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