HMGCL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.34066368
2L-phenylalanine catabolic process (GO:0006559)7.34066368
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.04413034
4L-phenylalanine metabolic process (GO:0006558)7.04413034
5aromatic amino acid family catabolic process (GO:0009074)6.55553527
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.04782685
7exogenous drug catabolic process (GO:0042738)5.87854576
8tryptophan catabolic process (GO:0006569)5.86099938
9indole-containing compound catabolic process (GO:0042436)5.86099938
10indolalkylamine catabolic process (GO:0046218)5.86099938
11glyoxylate metabolic process (GO:0046487)5.80738870
12kynurenine metabolic process (GO:0070189)5.65038484
13bile acid biosynthetic process (GO:0006699)5.58123483
14tryptophan metabolic process (GO:0006568)5.57755561
15alpha-linolenic acid metabolic process (GO:0036109)5.36874970
16high-density lipoprotein particle remodeling (GO:0034375)5.24447255
17sulfur amino acid catabolic process (GO:0000098)5.18772954
18cysteine metabolic process (GO:0006534)5.15306939
19epoxygenase P450 pathway (GO:0019373)5.14588892
20urea cycle (GO:0000050)5.05199084
21urea metabolic process (GO:0019627)5.05199084
22negative regulation of fibrinolysis (GO:0051918)5.02845613
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93196423
24peptidyl-glutamic acid carboxylation (GO:0017187)4.90442258
25protein carboxylation (GO:0018214)4.90442258
26serine family amino acid catabolic process (GO:0009071)4.86765180
27aromatic amino acid family metabolic process (GO:0009072)4.82873395
28regulation of fibrinolysis (GO:0051917)4.82859015
29bile acid metabolic process (GO:0008206)4.80844377
30complement activation, alternative pathway (GO:0006957)4.79607562
31regulation of cholesterol esterification (GO:0010872)4.75194371
32regulation of protein activation cascade (GO:2000257)4.74897406
33nitrogen cycle metabolic process (GO:0071941)4.68028903
34regulation of triglyceride catabolic process (GO:0010896)4.64262606
35lysine metabolic process (GO:0006553)4.61168202
36lysine catabolic process (GO:0006554)4.61168202
37reverse cholesterol transport (GO:0043691)4.59116562
38tyrosine metabolic process (GO:0006570)4.56072745
39plasma lipoprotein particle remodeling (GO:0034369)4.53862970
40protein-lipid complex remodeling (GO:0034368)4.53862970
41macromolecular complex remodeling (GO:0034367)4.53862970
42amino-acid betaine metabolic process (GO:0006577)4.51052427
43* alpha-amino acid catabolic process (GO:1901606)4.45437591
44regulation of complement activation (GO:0030449)4.42617329
45omega-hydroxylase P450 pathway (GO:0097267)4.42580475
46homocysteine metabolic process (GO:0050667)4.41774513
47phospholipid efflux (GO:0033700)4.36496901
48acylglycerol homeostasis (GO:0055090)4.30931526
49triglyceride homeostasis (GO:0070328)4.30931526
50* cellular ketone body metabolic process (GO:0046950)4.27536962
51aldehyde catabolic process (GO:0046185)4.27521060
52plasma lipoprotein particle clearance (GO:0034381)4.27188842
53negative regulation of cholesterol transport (GO:0032375)4.24482564
54negative regulation of sterol transport (GO:0032372)4.24482564
55amine catabolic process (GO:0009310)4.23536653
56cellular biogenic amine catabolic process (GO:0042402)4.23536653
57glycine metabolic process (GO:0006544)4.21922175
58drug metabolic process (GO:0017144)4.21366126
59indolalkylamine metabolic process (GO:0006586)4.19639702
60xenobiotic catabolic process (GO:0042178)4.18238697
61coenzyme catabolic process (GO:0009109)4.15592671
62* cellular amino acid catabolic process (GO:0009063)4.14746520
63bile acid and bile salt transport (GO:0015721)4.14102154
64serine family amino acid metabolic process (GO:0009069)4.13923290
65serine family amino acid biosynthetic process (GO:0009070)4.11887657
66S-adenosylmethionine metabolic process (GO:0046500)4.06824451
67cholesterol efflux (GO:0033344)4.05552161
68imidazole-containing compound metabolic process (GO:0052803)4.01837809
69ethanol oxidation (GO:0006069)4.00028552
70cellular glucuronidation (GO:0052695)3.98821842
71phenylpropanoid metabolic process (GO:0009698)3.98328136
72low-density lipoprotein particle remodeling (GO:0034374)3.93344911
73benzene-containing compound metabolic process (GO:0042537)3.88793062
74oxidative demethylation (GO:0070989)3.88527087
75glutamate metabolic process (GO:0006536)3.87534637
76cofactor catabolic process (GO:0051187)3.85916491
77short-chain fatty acid metabolic process (GO:0046459)3.83529998
78positive regulation of lipoprotein lipase activity (GO:0051006)3.83168957
79positive regulation of triglyceride lipase activity (GO:0061365)3.83168957
80arginine metabolic process (GO:0006525)3.80665062
81cellular modified amino acid catabolic process (GO:0042219)3.79115856
82plasma lipoprotein particle assembly (GO:0034377)3.77385357
83* carboxylic acid catabolic process (GO:0046395)3.75775716
84* organic acid catabolic process (GO:0016054)3.75775716
85drug catabolic process (GO:0042737)3.70094287
86acetyl-CoA metabolic process (GO:0006084)3.68741817
87heme transport (GO:0015886)3.67832900
88fibrinolysis (GO:0042730)3.63761700
89fatty acid beta-oxidation (GO:0006635)3.62811901
90glucuronate metabolic process (GO:0019585)3.61800154
91uronic acid metabolic process (GO:0006063)3.61800154
92* ketone body metabolic process (GO:1902224)3.60879750
93cholesterol homeostasis (GO:0042632)3.59140168
94aspartate family amino acid catabolic process (GO:0009068)3.58590075
95fatty acid oxidation (GO:0019395)3.58426406
96very-low-density lipoprotein particle assembly (GO:0034379)3.57812440
97blood coagulation, intrinsic pathway (GO:0007597)3.57584522
98phospholipid homeostasis (GO:0055091)3.56796696
99monocarboxylic acid catabolic process (GO:0072329)3.56357135
100NAD biosynthetic process (GO:0009435)3.54992877
101sterol homeostasis (GO:0055092)3.52868178
102lipid oxidation (GO:0034440)3.52506484
103drug transmembrane transport (GO:0006855)3.50614920
104fatty acid catabolic process (GO:0009062)3.50221690
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.49752197
106pyridine nucleotide biosynthetic process (GO:0019363)3.49752197
107flavonoid metabolic process (GO:0009812)3.49138229
108plasma lipoprotein particle organization (GO:0071827)3.46520033
109ethanol metabolic process (GO:0006067)3.41951960
110L-methionine salvage (GO:0071267)3.35463029
111L-methionine biosynthetic process (GO:0071265)3.35463029
112amino acid salvage (GO:0043102)3.35463029
113water-soluble vitamin biosynthetic process (GO:0042364)3.32884634
114vitamin biosynthetic process (GO:0009110)3.32782745
115fat-soluble vitamin biosynthetic process (GO:0042362)3.32680856
116doxorubicin metabolic process (GO:0044598)3.17354090
117daunorubicin metabolic process (GO:0044597)3.17354090
118polyketide metabolic process (GO:0030638)3.17354090
119arginine catabolic process (GO:0006527)3.13665660
120negative regulation of protein activation cascade (GO:2000258)3.09452947
121aminoglycoside antibiotic metabolic process (GO:0030647)2.94422959
122* branched-chain amino acid catabolic process (GO:0009083)2.91719577
123intestinal cholesterol absorption (GO:0030299)2.90867629
124xenobiotic metabolic process (GO:0006805)2.86159901
125quinone metabolic process (GO:1901661)2.85802327
126carnitine metabolic process (GO:0009437)2.81608192
127primary alcohol metabolic process (GO:0034308)2.76889270
128respiratory chain complex IV assembly (GO:0008535)2.75541736
129negative regulation of complement activation (GO:0045916)2.73390402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.81750783
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.76642043
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.70618364
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.94370923
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.27925665
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.16635218
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.86911210
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.18800897
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.43694922
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.94026150
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.31700183
12ZNF274_21170338_ChIP-Seq_K562_Hela2.26999444
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16687395
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.08666214
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2572604
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85685939
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.77855842
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68348708
19GATA1_22025678_ChIP-Seq_K562_Human1.67480604
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66449212
21GBX2_23144817_ChIP-Seq_PC3_Human1.65243103
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61317601
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.58799627
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57839278
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51346735
26HTT_18923047_ChIP-ChIP_STHdh_Human1.49844423
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49531056
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.48310223
29FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48310223
30VDR_22108803_ChIP-Seq_LS180_Human1.46226686
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43608766
32ER_23166858_ChIP-Seq_MCF-7_Human1.35514232
33NANOG_19829295_ChIP-Seq_ESCs_Human1.32893119
34SOX2_19829295_ChIP-Seq_ESCs_Human1.32893119
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.32675578
36FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32436766
37IGF1R_20145208_ChIP-Seq_DFB_Human1.32095575
38TP53_22573176_ChIP-Seq_HFKS_Human1.29423460
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29021197
40BCAT_22108803_ChIP-Seq_LS180_Human1.28812290
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28750445
42CLOCK_20551151_ChIP-Seq_293T_Human1.28391950
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25880869
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23511097
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22942287
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.22627773
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.22598343
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22148206
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.18966757
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18793713
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.18234275
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17800394
53CDX2_22108803_ChIP-Seq_LS180_Human1.15815954
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15262765
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13163766
56FOXH1_21741376_ChIP-Seq_EPCs_Human1.12253165
57MYC_19829295_ChIP-Seq_ESCs_Human1.11928275
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11462207
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.11061381
60VDR_23849224_ChIP-Seq_CD4+_Human1.10454176
61NCOR_22424771_ChIP-Seq_293T_Human1.08798880
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08680353
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08291557
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06208089
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05718428
66* PHF8_20622853_ChIP-Seq_HELA_Human1.05209751
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04852374
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02074189
69TCF4_22108803_ChIP-Seq_LS180_Human1.01840680
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01778997
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99875464
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99295300
73CBP_20019798_ChIP-Seq_JUKART_Human0.99295300
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99212400
75HNFA_21074721_ChIP-Seq_CACO-2_Human0.98928991
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97951720
77NANOG_20526341_ChIP-Seq_ESCs_Human0.97875099
78P300_19829295_ChIP-Seq_ESCs_Human0.96907614
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96017944
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95997227
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95310022
82* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95300531
83GATA3_26560356_Chip-Seq_TH2_Human0.94401276
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93705204
85RBPJ_21746931_ChIP-Seq_IB4_Human0.93508000
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93476565
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93067356
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.93035883
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92696104
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.91724110
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91424234
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91092577
93* SRF_21415370_ChIP-Seq_HL-1_Mouse0.90297967
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89896001
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89189972
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.89124720
97TAF15_26573619_Chip-Seq_HEK293_Human0.89123547
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89088694
99ELK1_19687146_ChIP-ChIP_HELA_Human0.88863389
100STAT1_20625510_ChIP-Seq_HELA_Human0.88614425
101CBP_21632823_ChIP-Seq_H3396_Human0.88536096
102CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87862423
103GATA4_25053715_ChIP-Seq_YYC3_Human0.87562562
104* ETV1_20927104_ChIP-Seq_GIST48_Human0.86882838
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84805381
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80906449
107* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77361759
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76164839
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.75817317
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.74522147
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73521317
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72539854
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72426676
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70051379
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68752603
116RARB_24833708_ChIP-Seq_LIVER_Mouse0.68387649
117IRF1_19129219_ChIP-ChIP_H3396_Human0.67599532
118AR_20517297_ChIP-Seq_VCAP_Human0.67357089
119* CEBPB_22108803_ChIP-Seq_LS180_Human0.66245853
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.65188399
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64436242
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63978974
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62869101
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.62676719
125EGR1_19032775_ChIP-ChIP_M12_Human0.62085975
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.61484684
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61324833
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61156559
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.61024683
130* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.59021579
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.58979514
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.57116504
133* IRF8_21731497_ChIP-ChIP_J774_Mouse0.56705418
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55813696
135TAF2_19829295_ChIP-Seq_ESCs_Human0.55511618
136MYC_19915707_ChIP-ChIP_AK7_Human0.55336134
137CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54833935
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.54809601
139* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.54086252
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.54059927
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.53765128
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53710773
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53382392
144GATA1_19941826_ChIP-Seq_K562_Human0.53186314
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.52643801
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.52643801
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52163771
148SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.50731028
149P53_21459846_ChIP-Seq_SAOS-2_Human0.49512469
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.49353389
151ERG_20517297_ChIP-Seq_VCAP_Human0.48843280
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.48798061
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48485142
154BCOR_27268052_Chip-Seq_Bcells_Human0.48455984
155* IRF8_27001747_Chip-Seq_BMDM_Mouse0.48193660
156SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48097730
157CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47681920
158GATA2_22383799_ChIP-Seq_G1ME_Mouse0.47049826
159CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.46168460
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.45283379
161CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.44690452
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.44523200
163FOXA1_25552417_ChIP-Seq_VCAP_Human0.44179216
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43388240
165STAT1_17558387_ChIP-Seq_HELA_Human0.43110842
166BCL6_27268052_Chip-Seq_Bcells_Human0.43087866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.83194889
2MP0005360_urolithiasis7.09155685
3MP0005085_abnormal_gallbladder_physiolo5.95887974
4MP0005365_abnormal_bile_salt5.78106659
5MP0008875_abnormal_xenobiotic_pharmacok4.89937259
6MP0003806_abnormal_nucleotide_metabolis4.65659685
7MP0009840_abnormal_foam_cell3.65854955
8MP0003252_abnormal_bile_duct3.62239291
9MP0010329_abnormal_lipoprotein_level3.37102199
10MP0005083_abnormal_biliary_tract2.91852023
11MP0003195_calcinosis2.89410044
12MP0005332_abnormal_amino_acid2.89120147
13MP0003191_abnormal_cellular_cholesterol2.61775031
14MP0001666_abnormal_nutrient_absorption2.52354671
15MP0004019_abnormal_vitamin_homeostasis2.18650475
16MP0000609_abnormal_liver_physiology2.10138868
17MP0002118_abnormal_lipid_homeostasis2.07268331
18MP0005319_abnormal_enzyme/_coenzyme1.87472983
19MP0001764_abnormal_homeostasis1.86421494
20MP0002138_abnormal_hepatobiliary_system1.83110492
21MP0003186_abnormal_redox_activity1.72931412
22MP0005451_abnormal_body_composition1.72638068
23MP0005584_abnormal_enzyme/coenzyme_acti1.69690785
24MP0009697_abnormal_copulation1.61984665
25MP0003656_abnormal_erythrocyte_physiolo1.60077654
26MP0003868_abnormal_feces_composition1.56911442
27MP0000372_irregular_coat_pigmentation1.50429130
28MP0009643_abnormal_urine_homeostasis1.46261225
29MP0003011_delayed_dark_adaptation1.40699849
30MP0005551_abnormal_eye_electrophysiolog1.38045412
31MP0003646_muscle_fatigue1.37334858
32MP0010386_abnormal_urinary_bladder1.24503990
33MP0006036_abnormal_mitochondrial_physio1.22360551
34MP0000604_amyloidosis1.21962418
35MP0009780_abnormal_chondrocyte_physiolo1.21880606
36MP0001984_abnormal_olfaction1.20072177
37MP0005636_abnormal_mineral_homeostasis1.17493135
38MP0009764_decreased_sensitivity_to1.17157477
39* MP0000598_abnormal_liver_morphology1.16533539
40MP0005646_abnormal_pituitary_gland1.15737370
41MP0003183_abnormal_peptide_metabolism1.15380101
42MP0008469_abnormal_protein_level1.09675502
43MP0009763_increased_sensitivity_to1.07144928
44MP0005645_abnormal_hypothalamus_physiol1.06027816
45MP0002909_abnormal_adrenal_gland1.05608926
46MP0003172_abnormal_lysosome_physiology1.00892240
47MP0005379_endocrine/exocrine_gland_phen1.00244910
48MP0005647_abnormal_sex_gland0.99763151
49MP0003724_increased_susceptibility_to0.97487420
50MP0009642_abnormal_blood_homeostasis0.91528040
51MP0002876_abnormal_thyroid_physiology0.91343961
52MP0004145_abnormal_muscle_electrophysio0.90671388
53MP0005058_abnormal_lysosome_morphology0.89908373
54MP0005253_abnormal_eye_physiology0.89835837
55MP0005376_homeostasis/metabolism_phenot0.88714095
56MP0005084_abnormal_gallbladder_morpholo0.87935214
57MP0002148_abnormal_hypersensitivity_rea0.87286753
58MP0005377_hearing/vestibular/ear_phenot0.86277736
59MP0003878_abnormal_ear_physiology0.86277736
60MP0006035_abnormal_mitochondrial_morpho0.83211875
61MP0005670_abnormal_white_adipose0.82386585
62MP0005408_hypopigmentation0.81977620
63MP0009765_abnormal_xenobiotic_induced0.81497237
64MP0001756_abnormal_urination0.81486244
65MP0003690_abnormal_glial_cell0.81044975
66MP0006072_abnormal_retinal_apoptosis0.80753369
67MP0001661_extended_life_span0.80469384
68MP0005671_abnormal_response_to0.77155763
69MP0003329_amyloid_beta_deposits0.75124421
70MP0003879_abnormal_hair_cell0.74214707
71MP0002078_abnormal_glucose_homeostasis0.73318375
72MP0010368_abnormal_lymphatic_system0.73189100
73MP0005266_abnormal_metabolism0.72589096
74MP0000685_abnormal_immune_system0.72408328
75MP0002254_reproductive_system_inflammat0.72336555
76MP0005464_abnormal_platelet_physiology0.72301879
77MP0006082_CNS_inflammation0.72025119
78MP0002090_abnormal_vision0.71677929
79MP0002168_other_aberrant_phenotype0.70016807
80MP0005220_abnormal_exocrine_pancreas0.69954635
81MP0005367_renal/urinary_system_phenotyp0.69891834
82MP0000516_abnormal_urinary_system0.69891834
83MP0005410_abnormal_fertilization0.68787902
84MP0002693_abnormal_pancreas_physiology0.67786135
85MP0004142_abnormal_muscle_tone0.67494112
86MP0004130_abnormal_muscle_cell0.67232222
87MP0003436_decreased_susceptibility_to0.67092762
88MP0005535_abnormal_body_temperature0.66974795
89MP0004147_increased_porphyrin_level0.66880209
90MP0001986_abnormal_taste_sensitivity0.66784527
91MP0005167_abnormal_blood-brain_barrier0.66187707
92MP0002971_abnormal_brown_adipose0.65600401
93MP0004043_abnormal_pH_regulation0.64837115
94MP0003045_fibrosis0.64715719
95MP0002136_abnormal_kidney_physiology0.64575159
96MP0002928_abnormal_bile_duct0.64181682
97MP0005334_abnormal_fat_pad0.64121075
98MP0002837_dystrophic_cardiac_calcinosis0.62700031
99MP0001905_abnormal_dopamine_level0.62517756
100MP0002163_abnormal_gland_morphology0.62252361
101MP0003718_maternal_effect0.61326333
102MP0002132_abnormal_respiratory_system0.58734048
103MP0004782_abnormal_surfactant_physiolog0.58162961
104MP0001944_abnormal_pancreas_morphology0.58093996
105MP0000013_abnormal_adipose_tissue0.58049973
106MP0009785_altered_susceptibility_to0.56658086
107MP0001853_heart_inflammation0.54965207
108MP0004381_abnormal_hair_follicle0.53382027
109MP0008873_increased_physiological_sensi0.51809538
110MP0000639_abnormal_adrenal_gland0.50231702
111MP0001845_abnormal_inflammatory_respons0.49950708
112MP0003705_abnormal_hypodermis_morpholog0.48466516
113MP0003638_abnormal_response/metabolism_0.48001500
114MP0005448_abnormal_energy_balance0.47997695
115MP0003075_altered_response_to0.47291605
116MP0005395_other_phenotype0.46242949
117MP0005025_abnormal_response_to0.45328577
118MP0002419_abnormal_innate_immunity0.45298237
119MP0000230_abnormal_systemic_arterial0.44354470
120MP0002822_catalepsy0.43211937
121MP0005166_decreased_susceptibility_to0.39179924
122MP0000249_abnormal_blood_vessel0.39071573
123MP0004883_abnormal_blood_vessel0.36402089
124MP0003953_abnormal_hormone_level0.36086230
125MP0005075_abnormal_melanosome_morpholog0.35725334
126MP0001835_abnormal_antigen_presentation0.35432496
127MP0001243_abnormal_dermal_layer0.33028915
128MP0005164_abnormal_response_to0.32758954
129MP0008872_abnormal_physiological_respon0.32710303
130MP0008874_decreased_physiological_sensi0.32668140
131MP0005666_abnormal_adipose_tissue0.32644167
132MP0009115_abnormal_fat_cell0.31012039
133MP0000920_abnormal_myelination0.29151291
134MP0001765_abnormal_ion_homeostasis0.27660419
135MP0005595_abnormal_vascular_smooth0.26586365
136MP0002135_abnormal_kidney_morphology0.25956599

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01184094
2Intrahepatic cholestasis (HP:0001406)6.52106522
3Deep venous thrombosis (HP:0002625)6.29905454
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.92776567
5Prolonged partial thromboplastin time (HP:0003645)5.92048705
6Hypobetalipoproteinemia (HP:0003563)5.84296114
7Xanthomatosis (HP:0000991)5.75432322
8Hyperlipoproteinemia (HP:0010980)5.15274070
9Complement deficiency (HP:0004431)4.60995018
10* Hyperammonemia (HP:0001987)4.43666358
11Joint hemorrhage (HP:0005261)4.39378912
12Hypolipoproteinemia (HP:0010981)4.32389621
13Hyperglycinemia (HP:0002154)4.26520404
14Ketosis (HP:0001946)4.10322175
15Abnormality of methionine metabolism (HP:0010901)4.06985308
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99232027
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97538821
18Hypoglycemic coma (HP:0001325)3.97293742
19Abnormality of glycine metabolism (HP:0010895)3.95475437
20Abnormality of serine family amino acid metabolism (HP:0010894)3.95475437
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.95205472
22Hyperglycinuria (HP:0003108)3.94289447
23Abnormality of the common coagulation pathway (HP:0010990)3.86496330
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83679155
25Fat malabsorption (HP:0002630)3.82099802
26Epidermoid cyst (HP:0200040)3.80148724
27Hypoalphalipoproteinemia (HP:0003233)3.70311202
28* Abnormality of fatty-acid metabolism (HP:0004359)3.66625134
29Abnormality of pyrimidine metabolism (HP:0004353)3.58533743
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.53434010
31Vacuolated lymphocytes (HP:0001922)3.49165267
32Conjugated hyperbilirubinemia (HP:0002908)3.42036931
33Abnormality of complement system (HP:0005339)3.33157409
34Abnormality of the intrinsic pathway (HP:0010989)3.31724488
35Hyperbilirubinemia (HP:0002904)3.28633739
36Hypercholesterolemia (HP:0003124)3.15217730
37Delayed CNS myelination (HP:0002188)3.09131899
38Abnormality of serum amino acid levels (HP:0003112)3.05448075
39Steatorrhea (HP:0002570)3.01256338
40* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.00781364
41* Dicarboxylic aciduria (HP:0003215)3.00781364
42Abnormality of nucleobase metabolism (HP:0010932)3.00618814
43Lethargy (HP:0001254)2.97269771
44Ketoacidosis (HP:0001993)2.96981385
45Systemic lupus erythematosus (HP:0002725)2.87490708
46Cerebral edema (HP:0002181)2.85721783
47* Metabolic acidosis (HP:0001942)2.84399461
48Generalized aminoaciduria (HP:0002909)2.81628605
49Hepatocellular necrosis (HP:0001404)2.78390476
50Abnormality of purine metabolism (HP:0004352)2.71661349
51Hepatocellular carcinoma (HP:0001402)2.70413299
52Mitochondrial inheritance (HP:0001427)2.64144765
53Gout (HP:0001997)2.63479065
54Spontaneous abortion (HP:0005268)2.60772763
55Increased CSF lactate (HP:0002490)2.54612163
56Myocardial infarction (HP:0001658)2.51674976
57Vascular calcification (HP:0004934)2.49728161
58Abnormality of the renal cortex (HP:0011035)2.42193651
59Acute necrotizing encephalopathy (HP:0006965)2.42007012
60Recurrent gram-negative bacterial infections (HP:0005420)2.41773117
61Abnormal gallbladder morphology (HP:0012437)2.40916313
62Vomiting (HP:0002013)2.40209690
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40085747
64Abnormality of polysaccharide metabolism (HP:0011012)2.40085747
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40085747
66Acanthocytosis (HP:0001927)2.39974669
67Bile duct proliferation (HP:0001408)2.39071322
68Abnormal biliary tract physiology (HP:0012439)2.39071322
69Cholecystitis (HP:0001082)2.38631888
70Abnormal gallbladder physiology (HP:0012438)2.38631888
71Glomerulonephritis (HP:0000099)2.36009282
72Medial flaring of the eyebrow (HP:0010747)2.35469929
73Irritability (HP:0000737)2.35307657
74Proximal tubulopathy (HP:0000114)2.34149800
75Cholelithiasis (HP:0001081)2.33175281
76Skin nodule (HP:0200036)2.33046944
77Opisthotonus (HP:0002179)2.32537842
78Mucopolysacchariduria (HP:0008155)2.32214658
79Urinary glycosaminoglycan excretion (HP:0003541)2.32214658
80Pancreatic cysts (HP:0001737)2.32184760
81Abnormality of glycolipid metabolism (HP:0010969)2.30480073
82Abnormality of liposaccharide metabolism (HP:0010968)2.30480073
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.30480073
84Glycosuria (HP:0003076)2.30361141
85Abnormality of urine glucose concentration (HP:0011016)2.30361141
86Hypochromic microcytic anemia (HP:0004840)2.28737384
87Hepatic necrosis (HP:0002605)2.28541605
88Hypothermia (HP:0002045)2.28454998
89Hypoglycemic seizures (HP:0002173)2.27929558
90Spastic diplegia (HP:0001264)2.27750584
91Abnormal mitochondria in muscle tissue (HP:0008316)2.27089556
92Sensorimotor neuropathy (HP:0007141)2.23921934
93Amyloidosis (HP:0011034)2.23367461
94Reduced antithrombin III activity (HP:0001976)2.23117991
95Brushfield spots (HP:0001088)2.21811344
96Lipid accumulation in hepatocytes (HP:0006561)2.20480190
97Progressive macrocephaly (HP:0004481)2.20424864
98Pancreatitis (HP:0001733)2.19625218
99Abolished electroretinogram (ERG) (HP:0000550)2.17545050
100Malnutrition (HP:0004395)2.17452307
101Pancreatic fibrosis (HP:0100732)2.17066476
102Type I transferrin isoform profile (HP:0003642)2.16670854
103Cardiovascular calcification (HP:0011915)2.14882441
104CNS demyelination (HP:0007305)2.14463454
105Renal Fanconi syndrome (HP:0001994)2.14426602
106Lactic acidosis (HP:0003128)2.13308271
107Dysostosis multiplex (HP:0000943)2.12092077
108Nausea (HP:0002018)2.12023614
109True hermaphroditism (HP:0010459)2.11188346
110Mitral stenosis (HP:0001718)2.11012087
111Gingival bleeding (HP:0000225)2.10012274
112Cerebral palsy (HP:0100021)2.08049896
113Rhabdomyolysis (HP:0003201)2.07339576
114Renal cortical cysts (HP:0000803)2.07062558
115Hydroxyprolinuria (HP:0003080)2.05196590
116Abnormality of proline metabolism (HP:0010907)2.05196590
117Chronic hepatic failure (HP:0100626)2.04559519
118Hyperphosphaturia (HP:0003109)2.03994220
119Alkalosis (HP:0001948)2.03906478
120Late onset (HP:0003584)2.02459577
121Abnormal protein glycosylation (HP:0012346)2.01792210
122Abnormal glycosylation (HP:0012345)2.01792210
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01792210
124Abnormal protein N-linked glycosylation (HP:0012347)2.01792210
125Abnormality of iron homeostasis (HP:0011031)2.00402042
126Retinal atrophy (HP:0001105)2.00119153
127Abnormality of midbrain morphology (HP:0002418)1.98231410
128Molar tooth sign on MRI (HP:0002419)1.98231410
129Enlarged kidneys (HP:0000105)1.97974295
130Neonatal onset (HP:0003623)1.97744265
131Thrombophlebitis (HP:0004418)1.97168582
132Abnormality of the gallbladder (HP:0005264)1.95856740
133Esophageal varix (HP:0002040)1.95722415
134Abnormality of transition element cation homeostasis (HP:0011030)1.95653420
135Respiratory failure (HP:0002878)1.95575730
136Elevated hepatic transaminases (HP:0002910)1.94258022
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93443777
138Menorrhagia (HP:0000132)1.92378445
139Increased serum pyruvate (HP:0003542)1.92064621
140Abnormality of glycolysis (HP:0004366)1.92064621
141Acute encephalopathy (HP:0006846)1.91125654
142Acute hepatic failure (HP:0006554)1.89326547
143Poikilocytosis (HP:0004447)1.89197986
144Rickets (HP:0002748)1.88445685
145Abnormal enzyme/coenzyme activity (HP:0012379)1.83371920
146Hyperinsulinemic hypoglycemia (HP:0000825)1.82357420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.61056775
2MAP4K23.99397798
3FGFR43.69421404
4ERN13.39729158
5SIK13.22870120
6BMPR1B2.94081278
7TIE12.61518735
8ADRBK22.54313323
9TAOK32.50993405
10STK162.37432267
11KDR2.35644096
12ERBB42.32388451
13ACVR1B2.31877078
14INSRR2.27268801
15MST42.09980636
16TYK21.98867536
17PHKG11.94699558
18PHKG21.94699558
19PIK3CG1.75683242
20ZAK1.75209319
21MST1R1.73907325
22NUAK11.73163945
23ABL21.67552919
24TBK11.65023769
25MAP2K31.64059716
26MAPK111.62234758
27PIM21.61120337
28FLT31.42481822
29PBK1.42480996
30MAP3K141.41529832
31MAPKAPK31.39990828
32EPHB11.36361906
33MAP2K41.34683569
34IRAK31.33026751
35TRIM281.32074360
36MUSK1.28269022
37TLK11.27477909
38PINK11.27002673
39MAP3K111.22899817
40MYLK1.21712480
41NEK91.20623079
42FRK1.19387885
43MAP3K31.15835103
44MAP4K11.15060101
45FER1.12389819
46FGFR21.09642891
47NME21.09146220
48TGFBR21.08363881
49MAP3K121.06510177
50JAK21.04948334
51EIF2AK11.04569023
52IKBKE1.04317271
53NLK0.99229830
54BLK0.96402425
55GRK60.95452889
56MAPK40.94973850
57PRKCE0.94001211
58TNK20.92190991
59PRKAA20.90852852
60PKN20.89538262
61ADRBK10.88452240
62JAK10.87986905
63MET0.84787113
64OXSR10.84401442
65CSF1R0.84253789
66TGFBR10.84099642
67CAMK2G0.83291875
68LIMK10.82996029
69MAPK120.82810558
70PDK20.81976991
71ZAP700.78090718
72KIT0.77099906
73VRK10.76983247
74VRK20.75344063
75GRK10.74966465
76TRIB30.73599101
77PTK60.73355946
78MAPK150.72666911
79DAPK20.72261621
80ERBB30.72104147
81MAP2K60.71160860
82MAP3K40.69995007
83MAP2K20.69679791
84IRAK20.68191944
85PRKCZ0.67460995
86TAOK20.67453455
87GSK3A0.65485564
88MAP3K70.65206099
89MAPK130.64797475
90IRAK40.63444905
91PRKACG0.61428290
92PKN10.61228712
93CSK0.60260114
94BTK0.59633293
95CSNK1G10.58952558
96WNK30.58935369
97PDPK10.58380901
98PRKCG0.58270367
99TEC0.57631614
100PAK30.57413206
101CSNK1G30.57235133
102PRKCQ0.57221847
103MAPK70.56501439
104EPHB20.54772695
105TESK20.54304979
106PDK40.54265424
107PDK30.54265424
108TXK0.53160761
109IRAK10.52397344
110OBSCN0.50084546
111PRKACA0.49283752
112NEK10.49188286
113LYN0.47762093
114CAMKK20.47683737
115IKBKB0.47605765
116STK38L0.47581607
117PRKCA0.47166697
118PTK2B0.47055586
119PIK3CA0.46540035
120JAK30.46511714
121CDK90.46025227
122MATK0.45222102
123ERBB20.44985167
124PRKAA10.44875366
125MAP2K70.43024966
126CSNK1A10.42876727
127CAMK2D0.41880830
128RPS6KA50.41456155
129PRKG10.41414335
130PRKCD0.40877395
131EIF2AK30.40876478
132FGFR30.40535932
133TRPM70.37710520
134MAP3K100.37668229
135GRK70.37524460
136ROCK10.37247618
137DYRK20.36697131
138PRKCI0.35413300
139IGF1R0.35329843
140DAPK30.34735409
141CSNK1G20.34495860
142LMTK20.33949446
143MAP2K10.32801493
144WNK40.32667429
145EPHA30.31821870
146SGK4940.31037513
147SGK2230.31037513
148ITK0.30339947
149SYK0.29924478
150STK390.29057903
151DYRK1B0.28697866

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.13346427
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17205248
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02763391
4Nitrogen metabolism_Homo sapiens_hsa009102.93873195
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77964417
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75015541
7Arginine biosynthesis_Homo sapiens_hsa002202.69888706
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59909689
9Tryptophan metabolism_Homo sapiens_hsa003802.59306301
10Fatty acid degradation_Homo sapiens_hsa000712.55984316
11* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53647156
12Complement and coagulation cascades_Homo sapiens_hsa046102.48893134
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22861922
14* Peroxisome_Homo sapiens_hsa041462.16879866
15* Butanoate metabolism_Homo sapiens_hsa006502.13929461
16Propanoate metabolism_Homo sapiens_hsa006402.13017690
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09984677
18Histidine metabolism_Homo sapiens_hsa003401.99465943
19Fatty acid metabolism_Homo sapiens_hsa012121.89121650
20Chemical carcinogenesis_Homo sapiens_hsa052041.88749223
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88581644
22PPAR signaling pathway_Homo sapiens_hsa033201.83854166
23beta-Alanine metabolism_Homo sapiens_hsa004101.80033598
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.78495911
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77199934
26Fatty acid elongation_Homo sapiens_hsa000621.75901946
27Staphylococcus aureus infection_Homo sapiens_hsa051501.72164095
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70109082
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68699254
30Retinol metabolism_Homo sapiens_hsa008301.64871174
31Sulfur metabolism_Homo sapiens_hsa009201.61712039
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61281752
33* Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60496790
34Caffeine metabolism_Homo sapiens_hsa002321.55539329
35Pyruvate metabolism_Homo sapiens_hsa006201.53164234
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53119154
37Phenylalanine metabolism_Homo sapiens_hsa003601.51277304
38Folate biosynthesis_Homo sapiens_hsa007901.48624950
39Selenocompound metabolism_Homo sapiens_hsa004501.45764659
40Tyrosine metabolism_Homo sapiens_hsa003501.38339970
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.37034666
42Steroid biosynthesis_Homo sapiens_hsa001001.31959668
43Carbon metabolism_Homo sapiens_hsa012001.30349857
44Bile secretion_Homo sapiens_hsa049761.28600050
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26113011
46Biosynthesis of amino acids_Homo sapiens_hsa012301.23380725
47Vitamin B6 metabolism_Homo sapiens_hsa007501.21735621
48Starch and sucrose metabolism_Homo sapiens_hsa005001.20242468
49Sulfur relay system_Homo sapiens_hsa041221.15262840
50Fat digestion and absorption_Homo sapiens_hsa049751.15088935
51ABC transporters_Homo sapiens_hsa020101.09920804
52Arginine and proline metabolism_Homo sapiens_hsa003301.08270274
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05081163
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.03631029
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.95950449
56Vitamin digestion and absorption_Homo sapiens_hsa049770.95531534
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92483608
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89783718
59Glutathione metabolism_Homo sapiens_hsa004800.88393544
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82228150
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81804842
62Pentose phosphate pathway_Homo sapiens_hsa000300.78795378
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75461900
64One carbon pool by folate_Homo sapiens_hsa006700.70169934
65Collecting duct acid secretion_Homo sapiens_hsa049660.69874579
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65448045
67Glycerolipid metabolism_Homo sapiens_hsa005610.63097437
68Lysine degradation_Homo sapiens_hsa003100.62569720
69* Metabolic pathways_Homo sapiens_hsa011000.60659903
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58821118
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55471814
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53430417
73Mineral absorption_Homo sapiens_hsa049780.53154178
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44373183
75Fructose and mannose metabolism_Homo sapiens_hsa000510.44242943
76Sphingolipid metabolism_Homo sapiens_hsa006000.43037956
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39579529
78Galactose metabolism_Homo sapiens_hsa000520.35463867
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34533380
80Linoleic acid metabolism_Homo sapiens_hsa005910.34325245
81Oxidative phosphorylation_Homo sapiens_hsa001900.28629649
82Prion diseases_Homo sapiens_hsa050200.28070402
83Phototransduction_Homo sapiens_hsa047440.27962370
84Fatty acid biosynthesis_Homo sapiens_hsa000610.27935496
85Type I diabetes mellitus_Homo sapiens_hsa049400.23689991
86N-Glycan biosynthesis_Homo sapiens_hsa005100.22153378
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20017397
88Rheumatoid arthritis_Homo sapiens_hsa053230.19413766
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.17021749
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16771157
91Parkinsons disease_Homo sapiens_hsa050120.13934727
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.12495145
93Insulin resistance_Homo sapiens_hsa049310.07553779
94Regulation of autophagy_Homo sapiens_hsa041400.07269270
95Arachidonic acid metabolism_Homo sapiens_hsa005900.07077390
96Other glycan degradation_Homo sapiens_hsa005110.03782579
97Proteasome_Homo sapiens_hsa030500.02927157
98Alzheimers disease_Homo sapiens_hsa050100.00936090
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.00318545
100Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1730735
101Hepatitis C_Homo sapiens_hsa05160-0.1661621
102Pertussis_Homo sapiens_hsa05133-0.1656092
103African trypanosomiasis_Homo sapiens_hsa05143-0.1631229
104Huntingtons disease_Homo sapiens_hsa05016-0.1418180
105Renin-angiotensin system_Homo sapiens_hsa04614-0.1210522
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1139211
107AMPK signaling pathway_Homo sapiens_hsa04152-0.0984539
108Glucagon signaling pathway_Homo sapiens_hsa04922-0.0938550
109Ether lipid metabolism_Homo sapiens_hsa00565-0.0586428
110Pyrimidine metabolism_Homo sapiens_hsa00240-0.0340738
111Lysosome_Homo sapiens_hsa04142-0.0154581
112Protein export_Homo sapiens_hsa03060-0.0095998

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