HMGCR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cholesterol biosynthetic process (GO:0006695)9.55431675
2pyrimidine nucleobase catabolic process (GO:0006208)8.44975798
3* sterol biosynthetic process (GO:0016126)8.42499684
4nucleobase catabolic process (GO:0046113)6.55774924
5fatty acid elongation (GO:0030497)6.50064323
6* isoprenoid biosynthetic process (GO:0008299)5.82735841
7establishment of mitochondrion localization (GO:0051654)5.64870756
8neuron cell-cell adhesion (GO:0007158)5.23474233
9long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.06441190
10response to lipoprotein particle (GO:0055094)4.87570089
11establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.71527644
12mitochondrion transport along microtubule (GO:0047497)4.71527644
13central nervous system myelination (GO:0022010)4.70327294
14axon ensheathment in central nervous system (GO:0032291)4.70327294
15dendrite morphogenesis (GO:0048813)4.52371754
16long-chain fatty acid biosynthetic process (GO:0042759)4.51718288
17central nervous system projection neuron axonogenesis (GO:0021952)4.49688200
18fatty-acyl-CoA biosynthetic process (GO:0046949)4.33673974
19presynaptic membrane assembly (GO:0097105)4.33253126
20dendritic spine morphogenesis (GO:0060997)4.31020172
21long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.23567127
22layer formation in cerebral cortex (GO:0021819)4.22417401
23negative regulation of neurotransmitter secretion (GO:0046929)4.14514205
24axonal fasciculation (GO:0007413)4.02728682
25negative regulation of neurotransmitter transport (GO:0051589)3.95094949
26pre-miRNA processing (GO:0031054)3.94008139
27neuron recognition (GO:0008038)3.89446247
28presynaptic membrane organization (GO:0097090)3.85751857
29cerebral cortex radially oriented cell migration (GO:0021799)3.78629101
30ensheathment of neurons (GO:0007272)3.75126705
31axon ensheathment (GO:0008366)3.75126705
32postsynaptic membrane organization (GO:0001941)3.71769803
33myelination (GO:0042552)3.71526536
34cell migration in hindbrain (GO:0021535)3.65847439
35apical protein localization (GO:0045176)3.62776028
36regulation of collateral sprouting (GO:0048670)3.61200610
37central nervous system neuron axonogenesis (GO:0021955)3.60295314
38cellular response to cholesterol (GO:0071397)3.59904023
39establishment of integrated proviral latency (GO:0075713)3.59822967
40limb bud formation (GO:0060174)3.54101422
41* cholesterol metabolic process (GO:0008203)3.52492012
42negative regulation of axonogenesis (GO:0050771)3.44898968
43response to follicle-stimulating hormone (GO:0032354)3.44427007
44thioester biosynthetic process (GO:0035384)3.37432895
45acyl-CoA biosynthetic process (GO:0071616)3.37432895
46fatty-acyl-CoA metabolic process (GO:0035337)3.36049705
47transmission of nerve impulse (GO:0019226)3.30015851
48nuclear pore organization (GO:0006999)3.27632709
49* steroid biosynthetic process (GO:0006694)3.25571993
50nuclear pore complex assembly (GO:0051292)3.22593738
51* alcohol biosynthetic process (GO:0046165)3.22325763
52detection of temperature stimulus involved in sensory perception (GO:0050961)3.19885616
53detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.19885616
54* sterol metabolic process (GO:0016125)3.18652784
55negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.17351100
56negative regulation of axon extension (GO:0030517)3.16228401
57axon extension (GO:0048675)3.15536613
58synaptic vesicle maturation (GO:0016188)3.15340358
59locomotory exploration behavior (GO:0035641)3.12717450
60semaphorin-plexin signaling pathway (GO:0071526)3.12070555
61exploration behavior (GO:0035640)3.11560792
62asymmetric protein localization (GO:0008105)3.10478769
63positive regulation of actin filament depolymerization (GO:0030836)3.08719440
64clathrin coat assembly (GO:0048268)3.06073159
65regulation of extent of cell growth (GO:0061387)3.05633850
66regulation of synaptic vesicle exocytosis (GO:2000300)3.04616911
67glycerophospholipid catabolic process (GO:0046475)3.01519240
68response to methylmercury (GO:0051597)3.01276605
69organelle transport along microtubule (GO:0072384)2.98409049
70regulation of NFAT protein import into nucleus (GO:0051532)2.96554640
71cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.95722404
72dorsal/ventral axis specification (GO:0009950)2.95495637
73protein localization to synapse (GO:0035418)2.94411082
74Rap protein signal transduction (GO:0032486)2.90670154
75neuron projection extension (GO:1990138)2.87713655
76positive regulation of protein depolymerization (GO:1901881)2.85204420
77ER overload response (GO:0006983)2.84963532
78neurofilament cytoskeleton organization (GO:0060052)2.83342637
79nerve growth factor signaling pathway (GO:0038180)2.83217804
80substantia nigra development (GO:0021762)2.82538067
81paraxial mesoderm development (GO:0048339)2.81366349
82regulation of axon extension (GO:0030516)2.80759405
83forebrain neuron differentiation (GO:0021879)2.79166836
84olfactory bulb development (GO:0021772)2.79087803
85very long-chain fatty acid metabolic process (GO:0000038)2.78737203
86regulation of posttranscriptional gene silencing (GO:0060147)2.78261889
87regulation of gene silencing by miRNA (GO:0060964)2.78261889
88regulation of gene silencing by RNA (GO:0060966)2.78261889
89DNA double-strand break processing (GO:0000729)2.77548212
90neurotransmitter-gated ion channel clustering (GO:0072578)2.77042005
91kidney morphogenesis (GO:0060993)2.74229375
92acetyl-CoA metabolic process (GO:0006084)2.74050063
93glutamate secretion (GO:0014047)2.73840483
94negative regulation of microtubule polymerization (GO:0031115)2.70976303
95dendrite development (GO:0016358)2.70731460
96myelin maintenance (GO:0043217)2.70443688
97inner ear receptor cell development (GO:0060119)2.68245932
98response to cholesterol (GO:0070723)2.67572600
99vocalization behavior (GO:0071625)2.66722719
100neuron migration (GO:0001764)2.66163179
101regulation of axonogenesis (GO:0050770)2.63801652
102regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62288344
103calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.62208539
104terpenoid biosynthetic process (GO:0016114)2.61686264
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61641750
106heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.61368259
107regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.60129819
108detection of temperature stimulus (GO:0016048)2.59584466
109response to vitamin E (GO:0033197)2.59449788
110dendritic spine organization (GO:0097061)2.59424089
111axonogenesis (GO:0007409)2.58618036
112positive regulation of protein complex disassembly (GO:0043243)2.57840748
113cerebellum development (GO:0021549)2.57785214
114axon cargo transport (GO:0008088)2.57645689
115chromatin remodeling at centromere (GO:0031055)2.57499652
116estrogen biosynthetic process (GO:0006703)2.57082502
117cellular response to sterol (GO:0036315)2.57063152
118negative regulation of neuron projection development (GO:0010977)2.56445133
119gamma-aminobutyric acid transport (GO:0015812)2.56112515
120ectodermal placode formation (GO:0060788)2.54357123
121neuronal stem cell maintenance (GO:0097150)2.53990989
122protein localization to kinetochore (GO:0034501)2.52973324
123establishment of viral latency (GO:0019043)2.52363387
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.49693455
125regulation of non-canonical Wnt signaling pathway (GO:2000050)2.49401736
126CENP-A containing nucleosome assembly (GO:0034080)2.48545503
127negative regulation of oligodendrocyte differentiation (GO:0048715)2.47076309
128regulation of development, heterochronic (GO:0040034)2.46232409
129acrosome assembly (GO:0001675)2.46160182
130gastrulation with mouth forming second (GO:0001702)2.45995246
131G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.44439906
132DNA damage response, detection of DNA damage (GO:0042769)2.44113547
133retinal ganglion cell axon guidance (GO:0031290)2.37940766
134myelin assembly (GO:0032288)2.37442700
135regulation of cell fate specification (GO:0042659)2.36038720
136ATP-dependent chromatin remodeling (GO:0043044)2.34586476
137lateral sprouting from an epithelium (GO:0060601)2.34352263
138negative regulation of glial cell differentiation (GO:0045686)2.34253907
139regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.32074517
140ganglion development (GO:0061548)2.31621949
141cell fate commitment involved in formation of primary germ layer (GO:0060795)2.30581477
142DNA topological change (GO:0006265)2.29677334
143heterochromatin organization (GO:0070828)2.29508246
144nonmotile primary cilium assembly (GO:0035058)2.29311915
145hippocampus development (GO:0021766)2.28545836
146response to phenylpropanoid (GO:0080184)2.28304361
147L-serine metabolic process (GO:0006563)2.27407698
148ephrin receptor signaling pathway (GO:0048013)2.27087123
149regulation of mRNA splicing, via spliceosome (GO:0048024)2.26708861
150DNA replication-dependent nucleosome assembly (GO:0006335)2.25886011
151DNA replication-dependent nucleosome organization (GO:0034723)2.25886011
152neuron remodeling (GO:0016322)2.25053557
153DNA replication-independent nucleosome assembly (GO:0006336)2.24531134
154DNA replication-independent nucleosome organization (GO:0034724)2.24531134
155pore complex assembly (GO:0046931)2.24488521
156regulation of centriole replication (GO:0046599)2.22779482
157positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.22406800
158positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.22406800
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.22406800
160intraciliary transport (GO:0042073)2.22282878
161cellular response to gonadotropin stimulus (GO:0071371)2.19600291
162regulation of timing of cell differentiation (GO:0048505)2.18737436
163alpha-linolenic acid metabolic process (GO:0036109)2.18573722
164mitotic metaphase plate congression (GO:0007080)2.17433289
165regulation of sister chromatid cohesion (GO:0007063)2.16069364
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.15514096
167synapse assembly (GO:0007416)2.14862848
168histone exchange (GO:0043486)2.13788958
169cerebral cortex cell migration (GO:0021795)2.13104763
170DNA ligation (GO:0006266)2.13011019
171neuron projection extension involved in neuron projection guidance (GO:1902284)2.12805971
172axon extension involved in axon guidance (GO:0048846)2.12805971
173protein localization to chromosome, centromeric region (GO:0071459)2.12035297
174regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.09580469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.67906514
2AR_21572438_ChIP-Seq_LNCaP_Human2.99686954
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98388211
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.97536400
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70431932
6EZH2_22144423_ChIP-Seq_EOC_Human2.68996695
7E2F7_22180533_ChIP-Seq_HELA_Human2.60522935
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53735797
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.51644467
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39305386
11OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.34565214
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.32582441
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22329331
14* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21319145
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.19228016
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16822227
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16561258
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.16286495
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.15476422
20TAF15_26573619_Chip-Seq_HEK293_Human2.14669825
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.08320060
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97297896
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96184776
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96073087
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83738726
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83411085
27REST_21632747_ChIP-Seq_MESCs_Mouse1.82238775
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80862885
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79991044
30P300_19829295_ChIP-Seq_ESCs_Human1.79295530
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79225383
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77155858
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.76734293
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71500596
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69895776
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.69389867
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68590408
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.67323022
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66634355
40FUS_26573619_Chip-Seq_HEK293_Human1.66485482
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64895482
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64761407
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.64483603
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64090966
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.63896581
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.63819883
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63546747
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63210123
49AR_21909140_ChIP-Seq_LNCAP_Human1.63062168
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62773117
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62111472
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61853993
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61770778
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61770778
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58044331
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.57545126
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53310638
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52951670
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52557653
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49931092
61* STAT3_23295773_ChIP-Seq_U87_Human1.48642413
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48204890
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47342031
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.46901968
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46310624
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46310624
67ER_23166858_ChIP-Seq_MCF-7_Human1.46127166
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.42587141
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42087393
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42023466
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41492157
72* ELK1_19687146_ChIP-ChIP_HELA_Human1.40593859
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40212884
74SMAD4_21799915_ChIP-Seq_A2780_Human1.39546460
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38730794
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38570606
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38501417
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38240882
79* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37555765
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.36488660
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.34511030
82RNF2_27304074_Chip-Seq_NSC_Mouse1.34282648
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.33948712
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32462718
85* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29384507
86IGF1R_20145208_ChIP-Seq_DFB_Human1.28707935
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27448249
88* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.26248531
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26189744
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.24341798
91VDR_22108803_ChIP-Seq_LS180_Human1.24316723
92* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23785903
93TCF4_23295773_ChIP-Seq_U87_Human1.23107934
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.22662212
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21682315
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20678371
97JUN_21703547_ChIP-Seq_K562_Human1.20473277
98IRF1_19129219_ChIP-ChIP_H3396_Human1.20122313
99TP53_18474530_ChIP-ChIP_U2OS_Human1.19879108
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19770343
101SOX9_26525672_Chip-Seq_HEART_Mouse1.19323883
102TP53_16413492_ChIP-PET_HCT116_Human1.18955716
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.18700405
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18663246
105RUNX2_22187159_ChIP-Seq_PCA_Human1.18179701
106DROSHA_22980978_ChIP-Seq_HELA_Human1.18075164
107* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17990763
108* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17519386
109MYC_18555785_ChIP-Seq_MESCs_Mouse1.16791303
110* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16657453
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16417501
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14848898
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.13430869
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13316527
115POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.13205439
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12736181
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12339419
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12339419
119EWS_26573619_Chip-Seq_HEK293_Human1.12249356
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10783749
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10756661
122* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10230496
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10186499
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10035366
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08758011
126AHR_22903824_ChIP-Seq_MCF-7_Human1.08223567
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07268318
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07014903
129* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06023574
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.05842847
131MYC_18940864_ChIP-ChIP_HL60_Human1.05825016
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04698679
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03223798
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01442767
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01319501
136AR_25329375_ChIP-Seq_VCAP_Human1.01300526
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.00681539
138PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00480765
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00417330
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99728048
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.98672643
142* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98638368
143ZNF274_21170338_ChIP-Seq_K562_Hela0.98511749
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98387608
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.98294282
146* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97427288
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.97124413
148TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96149989
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95799245
150* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95227901
151REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93934174
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92425124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.98066002
2MP0000778_abnormal_nervous_system3.85665847
3MP0002139_abnormal_hepatobiliary_system3.02586848
4MP0003329_amyloid_beta_deposits2.88664082
5MP0003880_abnormal_central_pattern2.78935250
6MP0000920_abnormal_myelination2.72689759
7MP0004859_abnormal_synaptic_plasticity2.68287778
8MP0009780_abnormal_chondrocyte_physiolo2.55542508
9MP0002734_abnormal_mechanical_nocicepti2.42696041
10MP0005423_abnormal_somatic_nervous2.27279164
11MP0003121_genomic_imprinting2.20627545
12MP0002063_abnormal_learning/memory/cond2.15327065
13MP0003635_abnormal_synaptic_transmissio2.14372128
14MP0002735_abnormal_chemical_nociception2.06141557
15MP0004885_abnormal_endolymph2.05407145
16MP0000955_abnormal_spinal_cord2.01307709
17MP0000566_synostosis1.98498149
18MP0004858_abnormal_nervous_system1.98182940
19MP0003941_abnormal_skin_development1.96424682
20MP0002733_abnormal_thermal_nociception1.94531712
21MP0003632_abnormal_nervous_system1.87998367
22MP0003634_abnormal_glial_cell1.87765857
23MP0004134_abnormal_chest_morphology1.87587311
24MP0002184_abnormal_innervation1.82798791
25MP0000569_abnormal_digit_pigmentation1.79779927
26MP0000579_abnormal_nail_morphology1.77079601
27MP0001529_abnormal_vocalization1.77072147
28MP0000604_amyloidosis1.72530213
29MP0002572_abnormal_emotion/affect_behav1.70867445
30MP0001348_abnormal_lacrimal_gland1.63774287
31MP0001293_anophthalmia1.63583173
32MP0004742_abnormal_vestibular_system1.62986064
33MP0009379_abnormal_foot_pigmentation1.60073272
34MP0001968_abnormal_touch/_nociception1.59466538
35MP0002638_abnormal_pupillary_reflex1.59447934
36MP0008057_abnormal_DNA_replication1.58162744
37MP0005408_hypopigmentation1.55474813
38MP0002882_abnormal_neuron_morphology1.53008947
39MP0005386_behavior/neurological_phenoty1.52718919
40MP0004924_abnormal_behavior1.52718919
41MP0009745_abnormal_behavioral_response1.52565865
42MP0004811_abnormal_neuron_physiology1.50765511
43MP0001486_abnormal_startle_reflex1.49946886
44MP0003693_abnormal_embryo_hatching1.47498618
45MP0003890_abnormal_embryonic-extraembry1.47203128
46MP0005248_abnormal_Harderian_gland1.46838118
47MP0006292_abnormal_olfactory_placode1.46076594
48MP0001440_abnormal_grooming_behavior1.45473435
49MP0002557_abnormal_social/conspecific_i1.45091546
50MP0002064_seizures1.44522670
51MP0001299_abnormal_eye_distance/1.44077661
52MP0001905_abnormal_dopamine_level1.43603978
53MP0005187_abnormal_penis_morphology1.43292331
54MP0008789_abnormal_olfactory_epithelium1.43214399
55MP0000372_irregular_coat_pigmentation1.42952952
56MP0000631_abnormal_neuroendocrine_gland1.42327010
57MP0002751_abnormal_autonomic_nervous1.41894885
58MP0004133_heterotaxia1.40805652
59MP0002152_abnormal_brain_morphology1.39602220
60MP0001177_atelectasis1.39417493
61MP0002822_catalepsy1.39386925
62MP0003690_abnormal_glial_cell1.38568263
63MP0008932_abnormal_embryonic_tissue1.38518636
64MP0001286_abnormal_eye_development1.36745620
65MP0004957_abnormal_blastocyst_morpholog1.35576407
66MP0003868_abnormal_feces_composition1.34825705
67MP0000537_abnormal_urethra_morphology1.34763913
68MP0003861_abnormal_nervous_system1.34300802
69MP0005171_absent_coat_pigmentation1.34272624
70MP0006276_abnormal_autonomic_nervous1.34024901
71MP0003567_abnormal_fetal_cardiomyocyte1.31821809
72MP0001970_abnormal_pain_threshold1.30572325
73MP0002084_abnormal_developmental_patter1.27038853
74MP0000049_abnormal_middle_ear1.23457451
75MP0000462_abnormal_digestive_system1.23246398
76MP0004142_abnormal_muscle_tone1.22713183
77MP0005394_taste/olfaction_phenotype1.22277391
78MP0005499_abnormal_olfactory_system1.22277391
79MP0006072_abnormal_retinal_apoptosis1.21125177
80MP0003195_calcinosis1.20353923
81MP0002066_abnormal_motor_capabilities/c1.19646189
82MP0002736_abnormal_nociception_after1.18418013
83MP0003136_yellow_coat_color1.18164026
84MP0003119_abnormal_digestive_system1.17441903
85MP0010094_abnormal_chromosome_stability1.17067845
86MP0008877_abnormal_DNA_methylation1.15235683
87MP0002102_abnormal_ear_morphology1.14913186
88MP0009703_decreased_birth_body1.14737392
89MP0003631_nervous_system_phenotype1.13854639
90MP0002233_abnormal_nose_morphology1.13693000
91MP0002067_abnormal_sensory_capabilities1.13436925
92MP0002272_abnormal_nervous_system1.13037167
93MP0003315_abnormal_perineum_morphology1.12219486
94MP0002909_abnormal_adrenal_gland1.11101537
95MP0000383_abnormal_hair_follicle1.10210916
96MP0008058_abnormal_DNA_repair1.09764057
97MP0004197_abnormal_fetal_growth/weight/1.08966148
98MP0002085_abnormal_embryonic_tissue1.08599280
99MP0005083_abnormal_biliary_tract1.08374207
100MP0002752_abnormal_somatic_nervous1.07633887
101MP0000647_abnormal_sebaceous_gland1.06709477
102MP0003787_abnormal_imprinting1.04437147
103MP0002653_abnormal_ependyma_morphology1.03813812
104MP0005645_abnormal_hypothalamus_physiol1.03378729
105MP0001485_abnormal_pinna_reflex1.03377866
106MP0001730_embryonic_growth_arrest1.03155301
107MP0002111_abnormal_tail_morphology1.02171697
108MP0002092_abnormal_eye_morphology1.01854893
109MP0005391_vision/eye_phenotype1.01225072
110MP0003937_abnormal_limbs/digits/tail_de1.01193673
111MP0002229_neurodegeneration1.00334066
112MP0003111_abnormal_nucleus_morphology0.99373537
113MP0010678_abnormal_skin_adnexa0.99023497
114MP0001672_abnormal_embryogenesis/_devel0.98819855
115MP0005380_embryogenesis_phenotype0.98819855
116MP0003123_paternal_imprinting0.98796554
117MP0003935_abnormal_craniofacial_develop0.98451646
118MP0003806_abnormal_nucleotide_metabolis0.97515648
119MP0005195_abnormal_posterior_eye0.97392299
120MP0003942_abnormal_urinary_system0.95852422
121MP0003718_maternal_effect0.95685482
122MP0001984_abnormal_olfaction0.94713177
123MP0002089_abnormal_postnatal_growth/wei0.94580894
124MP0005360_urolithiasis0.92128371
125MP0003077_abnormal_cell_cycle0.89951825
126MP0009250_abnormal_appendicular_skeleto0.89619226
127MP0002234_abnormal_pharynx_morphology0.89610880
128MP0001963_abnormal_hearing_physiology0.89079229
129MP0000428_abnormal_craniofacial_morphol0.89053611
130MP0003755_abnormal_palate_morphology0.88622931
131MP0000015_abnormal_ear_pigmentation0.87435046
132MP0009046_muscle_twitch0.84946906
133MP0003984_embryonic_growth_retardation0.83980334
134MP0002088_abnormal_embryonic_growth/wei0.82960205
135MP0001697_abnormal_embryo_size0.82901610
136MP0008995_early_reproductive_senescence0.81395776
137MP0002938_white_spotting0.81370898
138MP0003385_abnormal_body_wall0.80997366
139MP0002697_abnormal_eye_size0.80499257
140MP0003172_abnormal_lysosome_physiology0.80491557
141MP0003122_maternal_imprinting0.79722712
142MP0002282_abnormal_trachea_morphology0.78953463
143MP0003938_abnormal_ear_development0.78801389
144MP0010030_abnormal_orbit_morphology0.78608045
145MP0003011_delayed_dark_adaptation0.78349130
146MP0009672_abnormal_birth_weight0.77113228
147MP0002896_abnormal_bone_mineralization0.75733065
148MP0002081_perinatal_lethality0.74634374
149MP0001188_hyperpigmentation0.73447643
150MP0002090_abnormal_vision0.73358465
151MP0005409_darkened_coat_color0.73186108
152MP0005253_abnormal_eye_physiology0.73174746

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the corticospinal tract (HP:0002492)5.98507018
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.55198765
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.55198765
4Termporal pattern (HP:0011008)5.22324093
5Insidious onset (HP:0003587)5.22324093
6Neurofibrillary tangles (HP:0002185)4.35638118
7Cerebral inclusion bodies (HP:0100314)4.09060427
8Akinesia (HP:0002304)3.95641819
9Epiphyseal dysplasia (HP:0002656)3.88601750
10Hypoplastic pelvis (HP:0008839)3.41724538
11Supranuclear gaze palsy (HP:0000605)3.41387984
12Irregular epiphyses (HP:0010582)3.27765176
13Relative macrocephaly (HP:0004482)3.25345347
14Parakeratosis (HP:0001036)3.21681667
15Small epiphyses (HP:0010585)3.18877773
16Morphological abnormality of the pyramidal tract (HP:0002062)3.12385812
17Increased serum pyruvate (HP:0003542)3.02713364
18Abnormality of glycolysis (HP:0004366)3.02713364
19Abnormality of the labia minora (HP:0012880)3.00493533
20Hepatoblastoma (HP:0002884)2.94504335
21Medulloblastoma (HP:0002885)2.84367943
22Spastic gait (HP:0002064)2.83912548
23Vitreoretinal degeneration (HP:0000655)2.81187067
24Bifid tongue (HP:0010297)2.78956634
25Delayed epiphyseal ossification (HP:0002663)2.63182766
26Amyotrophic lateral sclerosis (HP:0007354)2.57143194
27Pachygyria (HP:0001302)2.56261927
28Abnormal lung lobation (HP:0002101)2.55925632
29Mild short stature (HP:0003502)2.55300765
30Ankle clonus (HP:0011448)2.55041562
31Epidermoid cyst (HP:0200040)2.51772852
32Broad alveolar ridges (HP:0000187)2.48371082
33Colon cancer (HP:0003003)2.40097363
34Hyperglycinemia (HP:0002154)2.40047698
35Overlapping toe (HP:0001845)2.39329244
36Excessive salivation (HP:0003781)2.38394215
37Drooling (HP:0002307)2.38394215
38Myelomeningocele (HP:0002475)2.37806414
39Septo-optic dysplasia (HP:0100842)2.33553679
40Scrotal hypoplasia (HP:0000046)2.33235840
41Partial agenesis of the corpus callosum (HP:0001338)2.30844400
42Ulnar claw (HP:0001178)2.27510271
43High anterior hairline (HP:0009890)2.27240627
44Enlarged epiphyses (HP:0010580)2.26058714
45Pheochromocytoma (HP:0002666)2.23772765
46Limb dystonia (HP:0002451)2.22173408
47Hypophosphatemic rickets (HP:0004912)2.20358033
48Aplasia/Hypoplasia of the sternum (HP:0006714)2.19902615
49Megalencephaly (HP:0001355)2.19191968
50Urinary urgency (HP:0000012)2.16441882
51Septate vagina (HP:0001153)2.16086210
52Hypsarrhythmia (HP:0002521)2.15787719
53Esophageal atresia (HP:0002032)2.13559528
54Increased nuchal translucency (HP:0010880)2.12950306
55Hammertoe (HP:0001765)2.11704235
56Cutaneous finger syndactyly (HP:0010554)2.11395106
57Lissencephaly (HP:0001339)2.11146813
58Lower limb muscle weakness (HP:0007340)2.10930242
59EEG with generalized epileptiform discharges (HP:0011198)2.09947549
60Mutism (HP:0002300)2.06108705
61Cortical dysplasia (HP:0002539)2.05809584
62Intrahepatic cholestasis (HP:0001406)2.04427780
63Action tremor (HP:0002345)2.04379686
64Cutaneous syndactyly (HP:0012725)2.03992956
65Absent eyebrow (HP:0002223)2.03400447
66Aqueductal stenosis (HP:0002410)2.03122837
67Labial hypoplasia (HP:0000066)2.02215557
68Vertebral clefting (HP:0008428)2.01786282
69Spastic paraplegia (HP:0001258)2.01715963
70Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01713515
71Hypoplasia of the brainstem (HP:0002365)2.01713515
72Large earlobe (HP:0009748)2.01093314
73Arthropathy (HP:0003040)2.00970558
74Thyroid carcinoma (HP:0002890)2.00453157
75Epileptiform EEG discharges (HP:0011182)1.98568404
76Heterotopia (HP:0002282)1.98391028
77Epileptic encephalopathy (HP:0200134)1.96861548
78Papillary thyroid carcinoma (HP:0002895)1.96187846
79Segmental peripheral demyelination/remyelination (HP:0003481)1.95721715
80Renal hypoplasia (HP:0000089)1.93310586
81Paraplegia (HP:0010550)1.92916237
82Ependymoma (HP:0002888)1.92764004
83Sensory axonal neuropathy (HP:0003390)1.92615818
84Hypoplastic female external genitalia (HP:0012815)1.90547882
85Hemivertebrae (HP:0002937)1.89832925
86Rhabdomyosarcoma (HP:0002859)1.89288940
87Bicornuate uterus (HP:0000813)1.89150330
88Clonus (HP:0002169)1.88775555
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.88347819
90Peripheral hypomyelination (HP:0007182)1.87011621
91Glioma (HP:0009733)1.86571479
92Anophthalmia (HP:0000528)1.85649398
93Abnormality of the vitreous humor (HP:0004327)1.85426552
94Pseudobulbar signs (HP:0002200)1.85380453
95Astrocytoma (HP:0009592)1.83013495
96Abnormality of the astrocytes (HP:0100707)1.83013495
97Trigonocephaly (HP:0000243)1.82738635
98Urinary bladder sphincter dysfunction (HP:0002839)1.82358041
99Asymmetric growth (HP:0100555)1.82066230
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81599498
101Polyphagia (HP:0002591)1.80009267
102Neuroendocrine neoplasm (HP:0100634)1.78524770
103Micropenis (HP:0000054)1.78440545
104Gastrointestinal atresia (HP:0002589)1.77302884
105Abnormal tarsal ossification (HP:0008369)1.77143521
106Nephroblastoma (Wilms tumor) (HP:0002667)1.75852896
107Decreased motor nerve conduction velocity (HP:0003431)1.75526317
108Blue irides (HP:0000635)1.74455066
109Abnormality of the parathyroid morphology (HP:0011766)1.74383501
110Cupped ribs (HP:0000887)1.73966317
111Lower limb asymmetry (HP:0100559)1.73372458
112Onion bulb formation (HP:0003383)1.73036022
113Anteriorly placed anus (HP:0001545)1.72663318
114Midline defect of the nose (HP:0004122)1.72350379
115Absent eyelashes (HP:0000561)1.72232184
116Absent frontal sinuses (HP:0002688)1.72065617
117Specific learning disability (HP:0001328)1.71709641
118Myokymia (HP:0002411)1.71393101
119Intestinal atresia (HP:0011100)1.70769956
120Proximal placement of thumb (HP:0009623)1.70711454
121Diminished movement (HP:0002374)1.70621833
122Abnormality of the lower motor neuron (HP:0002366)1.70108650
123Abnormality of incisor morphology (HP:0011063)1.69132325
124Embryonal renal neoplasm (HP:0011794)1.69105957
125Vaginal atresia (HP:0000148)1.68783825
126Narrow forehead (HP:0000341)1.68254379
127Genital tract atresia (HP:0001827)1.67793694
128Neoplasm of striated muscle (HP:0009728)1.67664291
129Turricephaly (HP:0000262)1.66610353
130Absent epiphyses (HP:0010577)1.66510054
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66510054
132Optic nerve hypoplasia (HP:0000609)1.65973880
133Vertebral arch anomaly (HP:0008438)1.65613625
134Abnormality of the antihelix (HP:0009738)1.65479345
135Hyperventilation (HP:0002883)1.65361958
136Fragile nails (HP:0001808)1.64837407
137Generalized hypotonia (HP:0001290)1.64323738
138Facial hemangioma (HP:0000329)1.64222015
139Skull defect (HP:0001362)1.64208866
140Apathy (HP:0000741)1.63658108
141Preaxial hand polydactyly (HP:0001177)1.62533985
142Omphalocele (HP:0001539)1.60574968
143Deviation of the thumb (HP:0009603)1.60367989
144Postaxial hand polydactyly (HP:0001162)1.60167046
145Bilateral microphthalmos (HP:0007633)1.59434820
146Vertebral hypoplasia (HP:0008417)1.58747176
147Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58747176
148Genu varum (HP:0002970)1.58457737
149Abnormality of the septum pellucidum (HP:0007375)1.58427914
150Cupped ear (HP:0000378)1.57901202
151Progressive cerebellar ataxia (HP:0002073)1.57399713
152Abnormality of salivation (HP:0100755)1.57389791
153Poor suck (HP:0002033)1.56892824
154Intention tremor (HP:0002080)1.56506593
155Abnormality of the metopic suture (HP:0005556)1.56238172
156Meckel diverticulum (HP:0002245)1.55785274
157Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.54635681
158Abdominal situs inversus (HP:0003363)1.53869830
159Abnormality of abdominal situs (HP:0011620)1.53869830
160Meningocele (HP:0002435)1.53635812
161Impaired vibration sensation in the lower limbs (HP:0002166)1.53420968
162Absent septum pellucidum (HP:0001331)1.53095041
163Abnormal sex determination (HP:0012244)1.52964440
164Sex reversal (HP:0012245)1.52964440
165Volvulus (HP:0002580)1.51703022
166Exotropia (HP:0000577)1.51275296
167Heterochromia iridis (HP:0001100)1.50942211
168Dandy-Walker malformation (HP:0001305)1.50567635
169Synostosis involving the elbow (HP:0003938)1.50441609
170Humeroradial synostosis (HP:0003041)1.50441609
171Supernumerary spleens (HP:0009799)1.50298401
172Capillary hemangiomas (HP:0005306)1.50037536
173Neoplasm of the oral cavity (HP:0100649)1.49056307
174Bifid scrotum (HP:0000048)1.48493477
175Arnold-Chiari malformation (HP:0002308)1.47973739
176Postaxial foot polydactyly (HP:0001830)1.47296360
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.46893038
178Abnormality of the ileum (HP:0001549)1.46499815
179Shoulder girdle muscle weakness (HP:0003547)1.45469659
180Shawl scrotum (HP:0000049)1.44849154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK17.31724052
2DYRK23.14696225
3TSSK63.09087256
4CASK2.76570622
5ERBB32.69260484
6BCR2.47871170
7EPHB12.35952861
8SRPK12.35629205
9MAPK132.34892666
10STK392.30082427
11TRIM282.29401823
12CDC72.07943297
13NEK12.03417333
14TNIK1.88069236
15PKN11.85108838
16UHMK11.81835337
17LIMK11.78272664
18WEE11.76796515
19PLK21.76497923
20PLK41.75237820
21TTK1.74148157
22MAP3K91.74012490
23MINK11.69390861
24CSNK1G21.67350789
25NTRK11.64876389
26KSR11.57903889
27NTRK21.52891178
28OXSR11.48610486
29CSNK1G31.47230809
30PNCK1.40914210
31CSNK1A1L1.36738777
32MKNK11.36415984
33MAP3K41.36226066
34FGR1.35959499
35MET1.33190175
36ERBB41.32163880
37BRD41.32010259
38PINK11.30975248
39PAK61.30484296
40LATS11.30323914
41ZAK1.27990239
42PAK31.22699812
43EPHA41.20274076
44NTRK31.17020007
45BUB11.16798770
46PBK1.16119707
47SGK4941.13850705
48SGK2231.13850705
49BRSK21.11686977
50MAP3K21.11525946
51DYRK31.09019868
52TYRO31.04099404
53CDK51.04047736
54PRPF4B1.03525131
55WNK41.02041022
56RET1.01380210
57FGFR21.01290646
58DYRK1A1.00174233
59CDK140.99918244
60EIF2AK30.99077979
61MAP3K100.98059239
62CSNK1G10.95953606
63KSR20.92348413
64MAP2K70.92092054
65PHKG20.91968023
66PHKG10.91968023
67TAF10.91633477
68PLK10.88449140
69CDK180.87314476
70EPHB20.86995223
71CDK150.85475971
72MARK20.83886363
73SCYL20.83791657
74WNK30.82862436
75CAMK1G0.80009294
76STK38L0.79658338
77BMPR1B0.79631861
78DAPK20.78472360
79ICK0.78106338
80ATR0.76847885
81EEF2K0.75331299
82GSK3A0.73829124
83CSNK1D0.73362903
84NUAK10.73039947
85TGFBR10.72032330
86MAP4K20.71877637
87CDK11A0.70893971
88CLK10.70338780
89PRKD30.69497788
90VRK10.69469090
91MST40.68918042
92LATS20.64833764
93ATM0.64812345
94PASK0.64812311
95STK240.63905786
96PRKCZ0.63794155
97CSNK1E0.63507011
98CHEK20.62181883
99STK30.61709156
100DYRK1B0.61574676
101EIF2AK20.61366184
102SIK20.57168172
103ALK0.55682199
104PRKCE0.54670036
105NEK20.54630353
106SGK20.53962393
107EPHA30.53950641
108RPS6KA20.53482339
109CDK10.53420740
110YES10.52931461
111TESK10.52814322
112RPS6KA40.51828619
113MAP2K40.51767165
114PRKCG0.51749994
115MKNK20.51426605
116FYN0.50968558
117PLK30.49209941
118BMPR20.49050601
119CAMK1D0.48976680
120RPS6KB10.48118056
121NEK90.48043580
122ROCK20.47558808
123PDGFRB0.47229604
124CHEK10.47140714
125MAPKAPK50.46768773
126DDR20.46512889
127TESK20.46050480
128PRKCH0.44899543
129SGK10.42627111
130BRSK10.42378142
131MAP3K60.40063944
132FGFR10.40033140
133CAMK2A0.39936176
134CSNK1A10.39260244
135PRKDC0.38759016
136NEK60.38519542
137CDK190.38473297
138CDK20.37959709
139MAPK90.36003832
140PTK20.35937175
141ADRBK10.34860078
142PRKCQ0.33993355
143AURKA0.33469785
144MST1R0.33455442

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001007.77283407
2* Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.33630121
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.95563732
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.91465390
5Butanoate metabolism_Homo sapiens_hsa006502.55653393
6Fatty acid elongation_Homo sapiens_hsa000622.38092931
7Axon guidance_Homo sapiens_hsa043602.30550441
8Protein export_Homo sapiens_hsa030602.05964412
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58023018
10Propanoate metabolism_Homo sapiens_hsa006401.56996315
11Sulfur metabolism_Homo sapiens_hsa009201.51509430
12Non-homologous end-joining_Homo sapiens_hsa034501.50451061
13Cell cycle_Homo sapiens_hsa041101.33825114
14Spliceosome_Homo sapiens_hsa030401.30005327
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29300237
16RNA transport_Homo sapiens_hsa030131.28873171
17Ether lipid metabolism_Homo sapiens_hsa005651.28817041
18Pyruvate metabolism_Homo sapiens_hsa006201.26235699
19mRNA surveillance pathway_Homo sapiens_hsa030151.24325521
20Basal transcription factors_Homo sapiens_hsa030221.20884113
21Serotonergic synapse_Homo sapiens_hsa047261.20049579
22Dopaminergic synapse_Homo sapiens_hsa047281.17689034
23Synaptic vesicle cycle_Homo sapiens_hsa047211.17335851
24Cholinergic synapse_Homo sapiens_hsa047251.13560702
25ErbB signaling pathway_Homo sapiens_hsa040121.09475904
26Fatty acid metabolism_Homo sapiens_hsa012121.07898359
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07613217
28Renal cell carcinoma_Homo sapiens_hsa052111.07161741
29Fanconi anemia pathway_Homo sapiens_hsa034601.05223248
30Long-term depression_Homo sapiens_hsa047301.04529141
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04302190
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01959765
33Endometrial cancer_Homo sapiens_hsa052130.99840788
34Vitamin B6 metabolism_Homo sapiens_hsa007500.97637529
35Glutamatergic synapse_Homo sapiens_hsa047240.96705210
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96624595
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.95153023
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94350392
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.93928067
40Mismatch repair_Homo sapiens_hsa034300.93496186
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93031614
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92531630
43Wnt signaling pathway_Homo sapiens_hsa043100.90276787
44RNA degradation_Homo sapiens_hsa030180.90213466
45GABAergic synapse_Homo sapiens_hsa047270.89932693
46Biosynthesis of amino acids_Homo sapiens_hsa012300.88940467
47Oocyte meiosis_Homo sapiens_hsa041140.87149419
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86880138
49Long-term potentiation_Homo sapiens_hsa047200.84774822
50Prion diseases_Homo sapiens_hsa050200.83884760
51Vibrio cholerae infection_Homo sapiens_hsa051100.83733959
52Adherens junction_Homo sapiens_hsa045200.81284966
53Glioma_Homo sapiens_hsa052140.80941968
54Circadian entrainment_Homo sapiens_hsa047130.80479112
55TGF-beta signaling pathway_Homo sapiens_hsa043500.79544927
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79023857
57Colorectal cancer_Homo sapiens_hsa052100.78005951
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76354280
59Cocaine addiction_Homo sapiens_hsa050300.75827405
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.74269548
61Gap junction_Homo sapiens_hsa045400.72479020
62Fatty acid degradation_Homo sapiens_hsa000710.71160704
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71130862
64Fat digestion and absorption_Homo sapiens_hsa049750.71000845
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70430092
66Alcoholism_Homo sapiens_hsa050340.70176406
67DNA replication_Homo sapiens_hsa030300.68516145
68Type II diabetes mellitus_Homo sapiens_hsa049300.67974678
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65680344
70Morphine addiction_Homo sapiens_hsa050320.65282891
71Lysine degradation_Homo sapiens_hsa003100.64114875
72Phagosome_Homo sapiens_hsa041450.63965487
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.63579349
74Dorso-ventral axis formation_Homo sapiens_hsa043200.62100410
75Carbon metabolism_Homo sapiens_hsa012000.61483609
76Fatty acid biosynthesis_Homo sapiens_hsa000610.60167399
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.58090457
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57777869
79Estrogen signaling pathway_Homo sapiens_hsa049150.57701092
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57695542
81Tryptophan metabolism_Homo sapiens_hsa003800.57314583
82Peroxisome_Homo sapiens_hsa041460.57275636
83Nucleotide excision repair_Homo sapiens_hsa034200.56851415
84Melanogenesis_Homo sapiens_hsa049160.56471032
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56193394
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55559362
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55251384
88Tight junction_Homo sapiens_hsa045300.55168877
89One carbon pool by folate_Homo sapiens_hsa006700.54624344
90RNA polymerase_Homo sapiens_hsa030200.54156096
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52047551
92p53 signaling pathway_Homo sapiens_hsa041150.51020994
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50886355
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50615657
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50476328
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.49987239
97Taste transduction_Homo sapiens_hsa047420.49466784
98Olfactory transduction_Homo sapiens_hsa047400.48990286
99Amphetamine addiction_Homo sapiens_hsa050310.48930431
100Ras signaling pathway_Homo sapiens_hsa040140.48814066
101Ovarian steroidogenesis_Homo sapiens_hsa049130.48381069
102Histidine metabolism_Homo sapiens_hsa003400.47819957
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47174080
104Sphingolipid metabolism_Homo sapiens_hsa006000.46501423
105Homologous recombination_Homo sapiens_hsa034400.45725869
106Insulin secretion_Homo sapiens_hsa049110.45631644
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45359860
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44906961
109Base excision repair_Homo sapiens_hsa034100.44574449
110Viral myocarditis_Homo sapiens_hsa054160.44490996
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43496764
112Arginine and proline metabolism_Homo sapiens_hsa003300.43358690
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42603743
114Hippo signaling pathway_Homo sapiens_hsa043900.42160906
115Nicotine addiction_Homo sapiens_hsa050330.42072076
116Vitamin digestion and absorption_Homo sapiens_hsa049770.42062174
117Thyroid hormone synthesis_Homo sapiens_hsa049180.41880384
118Collecting duct acid secretion_Homo sapiens_hsa049660.41590572
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40897134
120Prostate cancer_Homo sapiens_hsa052150.40085333
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39749913
122beta-Alanine metabolism_Homo sapiens_hsa004100.36755151
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36334230
124Hedgehog signaling pathway_Homo sapiens_hsa043400.35966831
125Selenocompound metabolism_Homo sapiens_hsa004500.35741051
126* Metabolic pathways_Homo sapiens_hsa011000.35582514
127GnRH signaling pathway_Homo sapiens_hsa049120.35340586
128Renin secretion_Homo sapiens_hsa049240.35320320
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35047790
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33054875
131MicroRNAs in cancer_Homo sapiens_hsa052060.31613511
132Pancreatic cancer_Homo sapiens_hsa052120.30814753
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.29343741
134Prolactin signaling pathway_Homo sapiens_hsa049170.29124264
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28989479
136Basal cell carcinoma_Homo sapiens_hsa052170.27185943
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.26114156
138Choline metabolism in cancer_Homo sapiens_hsa052310.25771744
139Nitrogen metabolism_Homo sapiens_hsa009100.24387773
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24383812
141Tyrosine metabolism_Homo sapiens_hsa003500.24307708
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24042753
143Hepatitis C_Homo sapiens_hsa051600.24014881
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23374855
145Melanoma_Homo sapiens_hsa052180.23102102
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22518652
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21368607
148Chemokine signaling pathway_Homo sapiens_hsa040620.20925998
149Type I diabetes mellitus_Homo sapiens_hsa049400.20681831
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20556698
151* Bile secretion_Homo sapiens_hsa049760.20234007
152N-Glycan biosynthesis_Homo sapiens_hsa005100.20102361

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