HMGCS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.95170324
2central nervous system myelination (GO:0022010)9.95170324
3fatty acid elongation (GO:0030497)8.93925190
4* cholesterol biosynthetic process (GO:0006695)7.90230154
5* sterol biosynthetic process (GO:0016126)6.94124910
6ensheathment of neurons (GO:0007272)6.09950198
7axon ensheathment (GO:0008366)6.09950198
8long-chain fatty acid biosynthetic process (GO:0042759)6.07036183
9myelination (GO:0042552)6.06315087
10long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.42455633
11* isoprenoid biosynthetic process (GO:0008299)5.18788025
12long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.97804871
13establishment of mitochondrion localization (GO:0051654)4.87211386
14nucleobase catabolic process (GO:0046113)4.85069005
15fatty-acyl-CoA biosynthetic process (GO:0046949)4.81527942
16myelin maintenance (GO:0043217)4.51765891
17negative regulation of neurotransmitter transport (GO:0051589)4.48737551
18fatty-acyl-CoA metabolic process (GO:0035337)4.37305749
19regulation of collateral sprouting (GO:0048670)4.32878273
20negative regulation of neurotransmitter secretion (GO:0046929)4.31074400
21response to methylmercury (GO:0051597)4.28655716
22apical protein localization (GO:0045176)4.21386265
23glycerophospholipid catabolic process (GO:0046475)4.14039533
24thioester biosynthetic process (GO:0035384)4.10962162
25acyl-CoA biosynthetic process (GO:0071616)4.10962162
26postsynaptic membrane organization (GO:0001941)4.02828978
27negative regulation of protein localization to cell surface (GO:2000009)4.02798969
28very long-chain fatty acid metabolic process (GO:0000038)3.97400200
29substantia nigra development (GO:0021762)3.96530104
30oligodendrocyte differentiation (GO:0048709)3.87713323
31asymmetric protein localization (GO:0008105)3.86021559
32positive regulation of oligodendrocyte differentiation (GO:0048714)3.75916578
33layer formation in cerebral cortex (GO:0021819)3.75592197
34photoreceptor cell differentiation (GO:0046530)3.65873592
35eye photoreceptor cell differentiation (GO:0001754)3.65873592
36presynaptic membrane organization (GO:0097090)3.57228578
37olfactory bulb development (GO:0021772)3.57088945
38amyloid precursor protein metabolic process (GO:0042982)3.48751978
39L-amino acid import (GO:0043092)3.48316196
40creatine metabolic process (GO:0006600)3.45381700
41regulation of development, heterochronic (GO:0040034)3.40092930
42central nervous system projection neuron axonogenesis (GO:0021952)3.40068957
43presynaptic membrane assembly (GO:0097105)3.37704040
44negative regulation of astrocyte differentiation (GO:0048712)3.37701681
45limb bud formation (GO:0060174)3.37279903
46peripheral nervous system axon ensheathment (GO:0032292)3.34529147
47myelination in peripheral nervous system (GO:0022011)3.34529147
48astrocyte development (GO:0014002)3.34318335
49neuron cell-cell adhesion (GO:0007158)3.31112475
50regulation of lipoprotein metabolic process (GO:0050746)3.30363756
51response to redox state (GO:0051775)3.24550727
52L-serine metabolic process (GO:0006563)3.23820261
53* alcohol biosynthetic process (GO:0046165)3.17220686
54* cholesterol metabolic process (GO:0008203)3.16936239
55detection of temperature stimulus involved in sensory perception (GO:0050961)3.15717034
56detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.15717034
57negative regulation of axonogenesis (GO:0050771)3.15124537
58negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.12504085
59acyl-CoA metabolic process (GO:0006637)3.05834621
60thioester metabolic process (GO:0035383)3.05834621
61axon development (GO:0061564)3.05275027
62regulation of timing of cell differentiation (GO:0048505)3.01458471
63import into cell (GO:0098657)3.00871373
64spinal cord development (GO:0021510)2.99404963
65cerebral cortex radially oriented cell migration (GO:0021799)2.98048981
66serine family amino acid catabolic process (GO:0009071)2.97569323
67* steroid biosynthetic process (GO:0006694)2.97225467
68acetyl-CoA metabolic process (GO:0006084)2.96349379
69neuron remodeling (GO:0016322)2.95339851
70retinal ganglion cell axon guidance (GO:0031290)2.93349516
71* sterol metabolic process (GO:0016125)2.88997212
72DNA double-strand break processing (GO:0000729)2.88419538
73dendritic spine morphogenesis (GO:0060997)2.88000430
74negative regulation of axon extension (GO:0030517)2.86784972
75negative regulation of glial cell differentiation (GO:0045686)2.86095617
76nonmotile primary cilium assembly (GO:0035058)2.83878966
77positive regulation of actin filament depolymerization (GO:0030836)2.83168731
78peripheral nervous system development (GO:0007422)2.81887961
79peptidyl-tyrosine autophosphorylation (GO:0038083)2.81798698
80vocalization behavior (GO:0071625)2.81595953
81protein neddylation (GO:0045116)2.80852255
82pyrimidine nucleobase catabolic process (GO:0006208)2.78791155
83forebrain neuron differentiation (GO:0021879)2.78036885
84mechanosensory behavior (GO:0007638)2.76171773
85triglyceride biosynthetic process (GO:0019432)2.75106140
86magnesium ion transport (GO:0015693)2.73552454
87mitochondrion transport along microtubule (GO:0047497)2.73538999
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.73538999
89neural nucleus development (GO:0048857)2.73199242
90auditory behavior (GO:0031223)2.72982088
91protein palmitoylation (GO:0018345)2.71967428
92nucleotide transmembrane transport (GO:1901679)2.71677279
93estrogen biosynthetic process (GO:0006703)2.70740754
94lateral sprouting from an epithelium (GO:0060601)2.70037596
95amyloid precursor protein catabolic process (GO:0042987)2.69701452
96neuron recognition (GO:0008038)2.68395964
97dorsal/ventral axis specification (GO:0009950)2.66781351
98L-phenylalanine catabolic process (GO:0006559)2.66343312
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.66343312
100neurotransmitter-gated ion channel clustering (GO:0072578)2.62488176
101acylglycerol biosynthetic process (GO:0046463)2.61457213
102neutral lipid biosynthetic process (GO:0046460)2.61457213
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.60994156
104central nervous system neuron axonogenesis (GO:0021955)2.60806280
105transmission of nerve impulse (GO:0019226)2.60517898
106iron coordination entity transport (GO:1901678)2.60271059
107amino acid import (GO:0043090)2.59876248
108neuronal stem cell maintenance (GO:0097150)2.58048344
109positive regulation of cellular amine metabolic process (GO:0033240)2.57295055
110detection of temperature stimulus (GO:0016048)2.56719642
111negative regulation of oligodendrocyte differentiation (GO:0048715)2.56547015
112membrane tubulation (GO:0097320)2.55458556
113cerebral cortex cell migration (GO:0021795)2.54747227
114nerve growth factor signaling pathway (GO:0038180)2.54552092
115calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.54039504
116glycosylceramide metabolic process (GO:0006677)2.52830049
117somite development (GO:0061053)2.52161272
118glial cell differentiation (GO:0010001)2.51671746
119response to phenylpropanoid (GO:0080184)2.50564368
120peptidyl-cysteine modification (GO:0018198)2.50468831
121axonal fasciculation (GO:0007413)2.49339024
122heme transport (GO:0015886)2.49032183
123C4-dicarboxylate transport (GO:0015740)2.46131837
124enteric nervous system development (GO:0048484)2.45627444
125positive regulation of neurological system process (GO:0031646)2.45088262
126adult walking behavior (GO:0007628)2.43949504
127neurotransmitter uptake (GO:0001504)2.43499377
128alpha-linolenic acid metabolic process (GO:0036109)2.41051796
129regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40561133
130terpenoid biosynthetic process (GO:0016114)2.40055697
131fatty acid biosynthetic process (GO:0006633)2.39887139
132negative regulation of axon extension involved in axon guidance (GO:0048843)2.39516429
133mitotic sister chromatid cohesion (GO:0007064)2.39312539
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.36876522
135positive regulation of synapse assembly (GO:0051965)2.36626497
136intraciliary transport (GO:0042073)2.35242356
137response to auditory stimulus (GO:0010996)2.34562353
138gastrulation with mouth forming second (GO:0001702)2.33476535
139DNA damage response, detection of DNA damage (GO:0042769)2.32792471
140axon extension (GO:0048675)2.30992815
141embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30903735
142dendrite morphogenesis (GO:0048813)2.30649346
143cell proliferation in forebrain (GO:0021846)2.28048386
144regulation of growth hormone secretion (GO:0060123)2.27977858
145positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.26469898
146DNA topological change (GO:0006265)2.26408164
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.24999143
148synapse assembly (GO:0007416)2.24919928
149serine family amino acid metabolic process (GO:0009069)2.23057894
150hindbrain development (GO:0030902)2.22411879
151regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.22355076
152generation of neurons (GO:0048699)2.21953026
153neuron migration (GO:0001764)2.21561820
154ephrin receptor signaling pathway (GO:0048013)2.20032535
155regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.18869450
156mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.18539899
157establishment of nucleus localization (GO:0040023)2.18248820
158lens morphogenesis in camera-type eye (GO:0002089)2.18219052
159protein localization to synapse (GO:0035418)2.15975304
160acrosome assembly (GO:0001675)2.15546762
161hippocampus development (GO:0021766)2.15124842
162chromatin remodeling at centromere (GO:0031055)2.14450875
163cysteine metabolic process (GO:0006534)2.13774055
164cell fate commitment involved in formation of primary germ layer (GO:0060795)2.13704771
165cell surface receptor signaling pathway involved in heart development (GO:0061311)2.13656834
166ectodermal placode formation (GO:0060788)2.13486623
167* cellular response to cholesterol (GO:0071397)2.13306212
168serine family amino acid biosynthetic process (GO:0009070)2.12908774
169atrial cardiac muscle cell action potential (GO:0086014)2.12870577
170negative regulation of mRNA processing (GO:0050686)2.10103860
171glycine metabolic process (GO:0006544)2.07827122
172negative regulation of gliogenesis (GO:0014014)2.07511114
173neural tube formation (GO:0001841)2.07204574
174negative regulation of axon guidance (GO:1902668)2.06472584
175cerebral cortex neuron differentiation (GO:0021895)2.05545203
176negative regulation of DNA-dependent DNA replication (GO:2000104)2.04917022
177cerebral cortex development (GO:0021987)2.03775004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.58243360
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.57266729
3GBX2_23144817_ChIP-Seq_PC3_Human3.21290570
4SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.66885708
5EZH2_22144423_ChIP-Seq_EOC_Human2.64709709
6IGF1R_20145208_ChIP-Seq_DFB_Human2.46098167
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43908369
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34971214
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33746709
10TAF15_26573619_Chip-Seq_HEK293_Human2.33415519
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27565003
12ZNF274_21170338_ChIP-Seq_K562_Hela2.27233838
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.21224699
14AR_21572438_ChIP-Seq_LNCaP_Human2.18719883
15OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.15175092
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07135049
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03332535
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03332535
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.02678844
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97293121
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96093831
22EWS_26573619_Chip-Seq_HEK293_Human1.94358962
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93874064
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92874003
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91450466
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88246646
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86567008
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84898890
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83299894
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.81935972
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.77473639
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77303736
33E2F7_22180533_ChIP-Seq_HELA_Human1.73302813
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73230631
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71160115
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69770659
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.69645131
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66523950
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65626874
40ER_23166858_ChIP-Seq_MCF-7_Human1.65516938
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.64710395
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63779901
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63497053
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62699509
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62669623
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58384751
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56581313
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55225474
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.54274194
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52443862
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.51456217
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50434656
53VDR_22108803_ChIP-Seq_LS180_Human1.50178072
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48688799
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47007527
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46835248
57P300_19829295_ChIP-Seq_ESCs_Human1.44722887
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44246522
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44130024
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42041429
61FUS_26573619_Chip-Seq_HEK293_Human1.41434644
62SOX9_26525672_Chip-Seq_HEART_Mouse1.40785814
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37898925
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.37060114
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35801236
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33566847
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33566847
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32579662
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32579662
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.31702676
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28504099
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.27218708
73AR_21909140_ChIP-Seq_LNCAP_Human1.24940583
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.24529607
75POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.23768084
76REST_21632747_ChIP-Seq_MESCs_Mouse1.22207784
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21801675
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21786652
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21749638
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.20891882
81DROSHA_22980978_ChIP-Seq_HELA_Human1.20070585
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.16837546
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15684778
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14834931
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.14780608
86STAT3_23295773_ChIP-Seq_U87_Human1.13399368
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12396853
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12151327
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11562397
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11562352
91* ELK1_19687146_ChIP-ChIP_HELA_Human1.11249596
92RNF2_27304074_Chip-Seq_NSC_Mouse1.11144776
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09947521
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.08943211
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08932014
96HTT_18923047_ChIP-ChIP_STHdh_Human1.08930796
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08712156
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08307316
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08283949
100SMAD4_21799915_ChIP-Seq_A2780_Human1.08195188
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08017954
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07681170
103CBP_20019798_ChIP-Seq_JUKART_Human1.07117019
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07117019
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06520858
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.05463011
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05358091
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.04225327
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.03816173
110AR_25329375_ChIP-Seq_VCAP_Human1.03763079
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.03573275
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02656557
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02329190
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.02025759
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02023110
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01715758
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01205379
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.01101387
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.00940850
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00788356
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00716161
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00533322
123RARB_27405468_Chip-Seq_BRAIN_Mouse1.00045096
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.99314563
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98704175
126REST_18959480_ChIP-ChIP_MESCs_Mouse0.98292915
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97815790
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96617091
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96605371
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96460050
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96404159
132HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96025091
133IRF1_19129219_ChIP-ChIP_H3396_Human0.95978270
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95880889
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95263684
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94861561
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94329292
138AHR_22903824_ChIP-Seq_MCF-7_Human0.93761682
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.93422288
140RUNX2_22187159_ChIP-Seq_PCA_Human0.92853834
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92772680
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91975626
143SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90876476
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.90769946
145TCF4_23295773_ChIP-Seq_U87_Human0.90533683
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90310902
147EOMES_21245162_ChIP-Seq_HESCs_Human0.90287423
148JUN_21703547_ChIP-Seq_K562_Human0.89810034
149NANOG_19829295_ChIP-Seq_ESCs_Human0.89325298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.76265975
2MP0003880_abnormal_central_pattern3.57664934
3MP0004270_analgesia3.52209741
4MP0001529_abnormal_vocalization3.02939703
5MP0003122_maternal_imprinting3.01306859
6MP0003329_amyloid_beta_deposits2.90789077
7MP0000778_abnormal_nervous_system2.87517298
8MP0003690_abnormal_glial_cell2.70282945
9MP0003950_abnormal_plasma_membrane2.55730664
10MP0004742_abnormal_vestibular_system2.42969669
11MP0004885_abnormal_endolymph2.34794078
12MP0001905_abnormal_dopamine_level2.34740781
13MP0003890_abnormal_embryonic-extraembry2.30032958
14MP0003121_genomic_imprinting2.28508595
15MP0005248_abnormal_Harderian_gland2.26011017
16MP0003634_abnormal_glial_cell2.25895537
17MP0003806_abnormal_nucleotide_metabolis2.23088966
18MP0006292_abnormal_olfactory_placode2.21333456
19MP0001486_abnormal_startle_reflex2.18310054
20MP0003136_yellow_coat_color2.15197416
21MP0002272_abnormal_nervous_system2.14858693
22MP0004142_abnormal_muscle_tone2.10446570
23MP0002734_abnormal_mechanical_nocicepti2.04982051
24MP0005171_absent_coat_pigmentation1.99981768
25MP0004859_abnormal_synaptic_plasticity1.93470366
26MP0005423_abnormal_somatic_nervous1.88563336
27MP0003632_abnormal_nervous_system1.88380813
28MP0002064_seizures1.88065500
29MP0001485_abnormal_pinna_reflex1.85961216
30MP0001984_abnormal_olfaction1.80300620
31MP0001293_anophthalmia1.78723572
32MP0005394_taste/olfaction_phenotype1.71830627
33MP0005499_abnormal_olfactory_system1.71830627
34MP0005187_abnormal_penis_morphology1.70690968
35MP0003635_abnormal_synaptic_transmissio1.69400785
36MP0004134_abnormal_chest_morphology1.66196478
37MP0008789_abnormal_olfactory_epithelium1.65861732
38MP0005451_abnormal_body_composition1.62819354
39MP0000955_abnormal_spinal_cord1.59032111
40MP0003119_abnormal_digestive_system1.54865149
41MP0005409_darkened_coat_color1.54546202
42MP0002229_neurodegeneration1.54451209
43MP0009745_abnormal_behavioral_response1.53436148
44MP0000462_abnormal_digestive_system1.53425982
45MP0000604_amyloidosis1.53007781
46MP0002063_abnormal_learning/memory/cond1.47909713
47MP0002139_abnormal_hepatobiliary_system1.43676880
48MP0003787_abnormal_imprinting1.42833324
49MP0002735_abnormal_chemical_nociception1.42747188
50MP0002653_abnormal_ependyma_morphology1.42605917
51MP0002882_abnormal_neuron_morphology1.42011128
52MP0003195_calcinosis1.40704272
53MP0003567_abnormal_fetal_cardiomyocyte1.40692653
54MP0010678_abnormal_skin_adnexa1.40074575
55MP0002733_abnormal_thermal_nociception1.39505186
56MP0002572_abnormal_emotion/affect_behav1.38587976
57MP0001968_abnormal_touch/_nociception1.38337720
58MP0001286_abnormal_eye_development1.38190060
59MP0002638_abnormal_pupillary_reflex1.38138321
60MP0002697_abnormal_eye_size1.37453207
61MP0001440_abnormal_grooming_behavior1.37034843
62MP0003631_nervous_system_phenotype1.35893753
63MP0009046_muscle_twitch1.35414742
64MP0006276_abnormal_autonomic_nervous1.35108765
65MP0002234_abnormal_pharynx_morphology1.34622568
66MP0003755_abnormal_palate_morphology1.34103086
67MP0001970_abnormal_pain_threshold1.33634952
68MP0000631_abnormal_neuroendocrine_gland1.29842274
69MP0005410_abnormal_fertilization1.29241917
70MP0010094_abnormal_chromosome_stability1.28929887
71MP0006072_abnormal_retinal_apoptosis1.27401628
72MP0001188_hyperpigmentation1.26064383
73MP0003385_abnormal_body_wall1.25956577
74MP0000647_abnormal_sebaceous_gland1.25745125
75MP0004924_abnormal_behavior1.24535827
76MP0005386_behavior/neurological_phenoty1.24535827
77MP0002092_abnormal_eye_morphology1.24396081
78MP0001299_abnormal_eye_distance/1.24032138
79MP0002067_abnormal_sensory_capabilities1.23233006
80MP0005391_vision/eye_phenotype1.21815603
81MP0008932_abnormal_embryonic_tissue1.21758967
82MP0002066_abnormal_motor_capabilities/c1.21647355
83MP0000049_abnormal_middle_ear1.21430273
84MP0004133_heterotaxia1.19766648
85MP0005551_abnormal_eye_electrophysiolog1.17706140
86MP0002752_abnormal_somatic_nervous1.17564385
87MP0002736_abnormal_nociception_after1.16518075
88MP0001177_atelectasis1.15979335
89MP0001963_abnormal_hearing_physiology1.15436156
90MP0002102_abnormal_ear_morphology1.14135543
91MP0002751_abnormal_autonomic_nervous1.14096177
92MP0003942_abnormal_urinary_system1.13584928
93MP0000383_abnormal_hair_follicle1.11578260
94MP0003937_abnormal_limbs/digits/tail_de1.10957151
95MP0002282_abnormal_trachea_morphology1.09828120
96MP0009703_decreased_birth_body1.09679932
97MP0008058_abnormal_DNA_repair1.07423483
98MP0004043_abnormal_pH_regulation1.07388096
99MP0003011_delayed_dark_adaptation1.06986633
100MP0009053_abnormal_anal_canal1.06779385
101MP0002184_abnormal_innervation1.06632207
102MP0009672_abnormal_birth_weight1.06302261
103MP0003633_abnormal_nervous_system1.05854923
104MP0003315_abnormal_perineum_morphology1.05733970
105MP0002111_abnormal_tail_morphology1.04541591
106MP0005408_hypopigmentation1.01970120
107MP0005083_abnormal_biliary_tract1.01227814
108MP0008877_abnormal_DNA_methylation1.00139915
109MP0002152_abnormal_brain_morphology0.99694867
110MP0000534_abnormal_ureter_morphology0.99550711
111MP0005195_abnormal_posterior_eye0.98942347
112MP0000762_abnormal_tongue_morphology0.98524230
113MP0003938_abnormal_ear_development0.98438477
114MP0000372_irregular_coat_pigmentation0.97377464
115MP0009250_abnormal_appendicular_skeleto0.95983119
116MP0003935_abnormal_craniofacial_develop0.95891381
117MP0002081_perinatal_lethality0.94975248
118MP0004858_abnormal_nervous_system0.94143265
119MP0004957_abnormal_blastocyst_morpholog0.94010948
120MP0002084_abnormal_developmental_patter0.93821246
121MP0004381_abnormal_hair_follicle0.92844794
122MP0000428_abnormal_craniofacial_morphol0.91745861
123MP0008569_lethality_at_weaning0.91041112
124MP0004197_abnormal_fetal_growth/weight/0.90820984
125MP0003941_abnormal_skin_development0.88062171
126MP0003111_abnormal_nucleus_morphology0.87907173
127MP0003123_paternal_imprinting0.87743682
128MP0008438_abnormal_cutaneous_collagen0.86992241
129MP0005623_abnormal_meninges_morphology0.86584740
130MP0002295_abnormal_pulmonary_circulatio0.86496359
131MP0002085_abnormal_embryonic_tissue0.86205666
132MP0000516_abnormal_urinary_system0.86115034
133MP0005367_renal/urinary_system_phenotyp0.86115034
134MP0000026_abnormal_inner_ear0.83826454
135MP0002557_abnormal_social/conspecific_i0.83813264
136MP0003718_maternal_effect0.82923272
137MP0000566_synostosis0.82820290
138MP0010030_abnormal_orbit_morphology0.82727657
139MP0002909_abnormal_adrenal_gland0.81302173
140MP0002822_catalepsy0.81188308
141MP0001346_abnormal_lacrimal_gland0.80549369
142MP0000747_muscle_weakness0.79166592
143MP0009780_abnormal_chondrocyte_physiolo0.78779947
144MP0004185_abnormal_adipocyte_glucose0.78749607
145MP0000579_abnormal_nail_morphology0.77918125
146MP0001340_abnormal_eyelid_morphology0.77712302
147MP0001661_extended_life_span0.75968433
148MP0003861_abnormal_nervous_system0.75903049
149MP0008260_abnormal_autophagy0.75713103
150MP0002090_abnormal_vision0.75459762
151MP0002938_white_spotting0.74088790
152MP0004811_abnormal_neuron_physiology0.73840868
153MP0000467_abnormal_esophagus_morphology0.70834824
154MP0005253_abnormal_eye_physiology0.70586657
155MP0000537_abnormal_urethra_morphology0.69624019
156MP0002233_abnormal_nose_morphology0.68986099
157MP0002118_abnormal_lipid_homeostasis0.66475923
158MP0001348_abnormal_lacrimal_gland0.65212924

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.40058559
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.40058559
3Neurofibrillary tangles (HP:0002185)5.71170968
4Parakeratosis (HP:0001036)5.29839679
5Abnormality of the corticospinal tract (HP:0002492)5.27950182
6Abnormality of glycolysis (HP:0004366)4.77650550
7Increased serum pyruvate (HP:0003542)4.77650550
8Termporal pattern (HP:0011008)4.62317556
9Insidious onset (HP:0003587)4.62317556
10Cerebral inclusion bodies (HP:0100314)4.40698277
11Sensory axonal neuropathy (HP:0003390)3.97377257
12Peripheral hypomyelination (HP:0007182)3.81965663
13Hepatoblastoma (HP:0002884)3.74207711
14Cortical dysplasia (HP:0002539)3.74139099
15Hypoplastic pelvis (HP:0008839)3.68494244
16Abnormality of the labia minora (HP:0012880)3.61557995
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.45772018
18Onion bulb formation (HP:0003383)3.45509023
19Supranuclear gaze palsy (HP:0000605)3.41105175
20Spastic gait (HP:0002064)3.38174002
21Hyperglycinemia (HP:0002154)3.29184195
22Congenital ichthyosiform erythroderma (HP:0007431)3.00123997
23Myokymia (HP:0002411)2.96410685
24Segmental peripheral demyelination/remyelination (HP:0003481)2.95344412
25Facial hemangioma (HP:0000329)2.91801152
26Akinesia (HP:0002304)2.85634131
27Leukodystrophy (HP:0002415)2.83330931
28Pheochromocytoma (HP:0002666)2.78025663
29Ankle clonus (HP:0011448)2.77103374
30Intention tremor (HP:0002080)2.75297515
31Abnormal auditory evoked potentials (HP:0006958)2.73233220
32Drooling (HP:0002307)2.70573373
33Cerebral hypomyelination (HP:0006808)2.67012410
34Myelomeningocele (HP:0002475)2.65883335
35Retinal dysplasia (HP:0007973)2.63475296
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.55759715
37Bifid tongue (HP:0010297)2.54661142
38Autoamputation (HP:0001218)2.52195941
39Dysmetria (HP:0001310)2.51655590
40Abnormal lung lobation (HP:0002101)2.49227626
41Volvulus (HP:0002580)2.48552956
42Stridor (HP:0010307)2.47686298
43Partial agenesis of the corpus callosum (HP:0001338)2.45231142
44Scanning speech (HP:0002168)2.43704595
45Renal hypoplasia (HP:0000089)2.39899164
46Hammertoe (HP:0001765)2.39448144
47Cerebral hemorrhage (HP:0001342)2.37193958
48Excessive salivation (HP:0003781)2.37099041
49Morphological abnormality of the pyramidal tract (HP:0002062)2.36515704
50Neuroendocrine neoplasm (HP:0100634)2.35391031
51Absent septum pellucidum (HP:0001331)2.31266307
52Slow saccadic eye movements (HP:0000514)2.30624511
53Spastic paraparesis (HP:0002313)2.29525283
54True hermaphroditism (HP:0010459)2.29506284
55Action tremor (HP:0002345)2.26116560
56Megalencephaly (HP:0001355)2.25298058
57Adrenal hypoplasia (HP:0000835)2.22915445
58Ulnar claw (HP:0001178)2.21826089
59Increased nuchal translucency (HP:0010880)2.21816017
60Alacrima (HP:0000522)2.20412856
61Lower limb muscle weakness (HP:0007340)2.19383230
62Colon cancer (HP:0003003)2.18776181
63Relative macrocephaly (HP:0004482)2.17757882
64Epidermoid cyst (HP:0200040)2.17278375
65Coronal craniosynostosis (HP:0004440)2.15199906
66Cutaneous finger syndactyly (HP:0010554)2.15108236
67Long clavicles (HP:0000890)2.14004887
68Foot dorsiflexor weakness (HP:0009027)2.13579998
69Lissencephaly (HP:0001339)2.12840390
70Hypophosphatemic rickets (HP:0004912)2.12648291
71Scrotal hypoplasia (HP:0000046)2.12045917
72Decreased motor nerve conduction velocity (HP:0003431)2.10979036
73Pancreatic fibrosis (HP:0100732)2.09648342
74Intestinal atresia (HP:0011100)2.09240652
75Abnormality of glycine metabolism (HP:0010895)2.08021725
76Abnormality of serine family amino acid metabolism (HP:0010894)2.08021725
77Urinary urgency (HP:0000012)2.07697926
78Broad alveolar ridges (HP:0000187)2.07479994
79Labial hypoplasia (HP:0000066)2.06921070
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06658283
81Abnormality of the phalanges of the 2nd finger (HP:0009541)2.05922190
82Abnormality of the metopic suture (HP:0005556)2.05851961
83Anomalous pulmonary venous return (HP:0010772)2.05811124
84Hypoplastic female external genitalia (HP:0012815)2.04702873
85Postaxial hand polydactyly (HP:0001162)2.03670317
86Intrahepatic cholestasis (HP:0001406)2.03016269
87Hemivertebrae (HP:0002937)2.02848138
88Steppage gait (HP:0003376)2.02264938
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99143120
90Short 4th metacarpal (HP:0010044)1.99143120
91Increased circulating renin level (HP:0000848)1.98717889
92Abnormality of the septum pellucidum (HP:0007375)1.98214399
93Focal motor seizures (HP:0011153)1.98049138
94Postaxial foot polydactyly (HP:0001830)1.96975450
95Methylmalonic acidemia (HP:0002912)1.96857052
96Supernumerary spleens (HP:0009799)1.95958859
97Genital tract atresia (HP:0001827)1.94491971
98Pachygyria (HP:0001302)1.94039800
99Abnormality of the foot musculature (HP:0001436)1.93745324
100Medulloblastoma (HP:0002885)1.93605211
101High anterior hairline (HP:0009890)1.93568966
102Narrow forehead (HP:0000341)1.92051918
103Vitreoretinal degeneration (HP:0000655)1.91992521
104Gait imbalance (HP:0002141)1.91944085
105Thickened helices (HP:0000391)1.91300315
106Anteriorly placed anus (HP:0001545)1.90864106
107Clonus (HP:0002169)1.90028306
108Overlapping toe (HP:0001845)1.89643870
109Infantile muscular hypotonia (HP:0008947)1.89600662
110Clumsiness (HP:0002312)1.89476857
111Cupped ear (HP:0000378)1.89260387
112Cutaneous syndactyly (HP:0012725)1.88765183
113Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.88648048
114Hyperglycinuria (HP:0003108)1.87054143
115Aplasia involving bones of the upper limbs (HP:0009823)1.86826009
116Aplasia of the phalanges of the hand (HP:0009802)1.86826009
117Aplasia involving bones of the extremities (HP:0009825)1.86826009
118Sclerocornea (HP:0000647)1.86126208
119Meningocele (HP:0002435)1.86072846
120Distal sensory impairment (HP:0002936)1.85695450
121Abnormality of the middle phalanges of the toes (HP:0010183)1.85601125
122Micropenis (HP:0000054)1.84622392
123Septate vagina (HP:0001153)1.84521906
124Molar tooth sign on MRI (HP:0002419)1.83905252
125Abnormality of midbrain morphology (HP:0002418)1.83905252
126Epiphyseal dysplasia (HP:0002656)1.83814109
127Split foot (HP:0001839)1.83678707
128Preaxial hand polydactyly (HP:0001177)1.82856286
129Hypomagnesemia (HP:0002917)1.82121027
130Septo-optic dysplasia (HP:0100842)1.81360182
131Morphological abnormality of the inner ear (HP:0011390)1.80423957
132Generalized hypotonia (HP:0001290)1.80181593
133Papillary thyroid carcinoma (HP:0002895)1.79924233
134Premature skin wrinkling (HP:0100678)1.79815503
135Optic nerve hypoplasia (HP:0000609)1.79478866
136Hemiparesis (HP:0001269)1.79277337
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.78683458
138Spastic tetraparesis (HP:0001285)1.78320795
139Abnormality of the vitreous humor (HP:0004327)1.76823445
140Abnormality of the pulmonary veins (HP:0011718)1.75195678
141Bicornuate uterus (HP:0000813)1.74476091
142Spastic paraplegia (HP:0001258)1.74153988
143Trigonocephaly (HP:0000243)1.74128107
144Oligodactyly (hands) (HP:0001180)1.74035373
145Oligodactyly (HP:0012165)1.72540973
146Dandy-Walker malformation (HP:0001305)1.72406291
147Absent eyebrow (HP:0002223)1.72325312
148Polyphagia (HP:0002591)1.72039769
149Anophthalmia (HP:0000528)1.70751458
150Pancreatic cysts (HP:0001737)1.70274667
151Gastrointestinal atresia (HP:0002589)1.70111433
152Glioma (HP:0009733)1.69979949
153Broad foot (HP:0001769)1.69870284
154Hypoplastic labia majora (HP:0000059)1.69193194
155Esophageal atresia (HP:0002032)1.69051140
156Specific learning disability (HP:0001328)1.68965871
157Congenital primary aphakia (HP:0007707)1.67689345
158Nephronophthisis (HP:0000090)1.67636732
159Nephrogenic diabetes insipidus (HP:0009806)1.67323813
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.67239525
161Short tibia (HP:0005736)1.67131891
162Hypoplasia of the iris (HP:0007676)1.67096100
163Urinary incontinence (HP:0000020)1.66856865
164Acute necrotizing encephalopathy (HP:0006965)1.66759650
165Synostosis involving the elbow (HP:0003938)1.66418780
166Humeroradial synostosis (HP:0003041)1.66418780
167Morphological abnormality of the middle ear (HP:0008609)1.66351694
168Abnormality of the diencephalon (HP:0010662)1.66078886
169Bifid scrotum (HP:0000048)1.64009350
170Impaired vibration sensation in the lower limbs (HP:0002166)1.64006515
171Hypoplastic left heart (HP:0004383)1.63548383
172Vaginal atresia (HP:0000148)1.63469862
173Decreased lacrimation (HP:0000633)1.63389315
174Paraplegia (HP:0010550)1.62991278
175Acute encephalopathy (HP:0006846)1.62248713
176Hepatosplenomegaly (HP:0001433)1.61952817
177Limb dystonia (HP:0002451)1.61859054
178Barrel-shaped chest (HP:0001552)1.61543696
179Neoplasm of the oral cavity (HP:0100649)1.61004808
180Abnormality of the lower motor neuron (HP:0002366)1.59759841
181Poor suck (HP:0002033)1.59457577
182Preaxial foot polydactyly (HP:0001841)1.59391572
183Medial flaring of the eyebrow (HP:0010747)1.59147438
184Anencephaly (HP:0002323)1.59123337
185Chronic hepatic failure (HP:0100626)1.58186769
186Microglossia (HP:0000171)1.58068921
187Impulsivity (HP:0100710)1.57915321
188Spastic diplegia (HP:0001264)1.57236578
189Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56332893
190Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.55901574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.80616659
2OXSR13.87143431
3EPHB13.61596150
4BCR3.27992241
5WNK42.65735479
6PBK2.57223282
7MARK12.53276246
8LIMK12.47340239
9PKN12.45789181
10MKNK22.38491081
11MAPKAPK52.30410806
12TRIM282.23973508
13UHMK12.05695404
14TSSK62.01839132
15FGFR21.98380890
16MET1.96255678
17CSNK1G31.95585770
18WEE11.92473131
19CSNK1A1L1.78935247
20NTRK11.77350869
21DYRK21.77318574
22CASK1.74550251
23PNCK1.72076183
24TNIK1.71880193
25ERBB31.71701533
26SRPK11.71200030
27TESK21.70266759
28CDK191.59352970
29NEK11.58864085
30WNK11.57451174
31MST41.56157028
32CSNK1G21.55431891
33PLK41.49236244
34CSNK1G11.48596638
35EPHA31.47996109
36SGK2231.44226737
37SGK4941.44226737
38FGR1.40368427
39ROCK21.39544052
40TYRO31.39416744
41CDC71.38989163
42PAK61.35890083
43PLK31.35610058
44NUAK11.34756647
45ERBB41.26952166
46PAK31.22619362
47CAMK2B1.20912564
48MAPK131.19416074
49YES11.13200150
50TTK1.12857071
51NTRK21.12779478
52EPHA41.12580886
53PRKD31.12229613
54ICK1.08246338
55LATS11.07027755
56NEK61.06649645
57CLK11.05100693
58BRD41.04753790
59CDK141.01389727
60BMPR1B0.98142822
61DYRK30.97804180
62PRPF4B0.96661716
63CAMK2D0.93821958
64EIF2AK30.90558645
65PLK20.89660039
66CDK50.88722895
67KSR20.88049457
68PHKG10.87570554
69PHKG20.87570554
70BRSK20.86088766
71MAP4K20.84915160
72CDK150.84241081
73CDK180.83599357
74NEK20.82382448
75CAMK2A0.82333007
76LATS20.82262464
77RPS6KA40.80498108
78PLK10.77683358
79EIF2AK10.75736134
80MAP3K100.75212959
81MINK10.73708917
82CDK11A0.73708361
83MAP3K90.72871763
84MAP3K40.70586030
85CAMK2G0.70118851
86ARAF0.69380767
87MARK20.68713835
88TAF10.66928833
89PRKCE0.65841295
90PINK10.64466098
91PRKCQ0.64285693
92ATM0.63071221
93BUB10.61400038
94IRAK20.61019779
95ATR0.60107851
96WNK30.60068469
97FGFR10.59908125
98ZAK0.59425500
99GSK3A0.55439899
100PRKD10.55431361
101MKNK10.55260966
102MAP3K20.54927659
103DYRK1A0.54259737
104CDK30.54239808
105EIF2AK20.53244111
106DDR20.53181178
107TGFBR10.52545477
108CAMK1D0.52315725
109FER0.52125169
110CSNK1D0.51932552
111VRK10.50726955
112KSR10.50487755
113SIK30.48753503
114STK30.48243480
115CCNB10.47287054
116CAMK1G0.46769019
117CHEK20.46732448
118FYN0.46385452
119PRKDC0.45545713
120ROCK10.44548515
121MAPK150.44230748
122PRKG10.43636869
123CHEK10.42711803
124MAP2K20.41263222
125* CDK10.41167809
126MAP2K40.40923790
127NTRK30.39237033
128PRKACB0.39173240
129PDPK10.38770957
130ACVR1B0.38696715
131SGK20.38091459
132BRSK10.35733898
133RET0.35561218
134CSNK1A10.35168671
135EPHB20.35000096
136ADRBK10.33167131
137CSNK1E0.32463512
138MAP2K70.32154005
139PDGFRB0.30748602
140PRKACA0.30639696
141GRK50.30531402
142RPS6KA50.29194261
143ERBB20.28777258
144LMTK20.27667764
145DAPK20.25726318
146PAK10.25456899
147PIK3CA0.25376188
148PRKCZ0.25215713
149STK110.24944051
150GRK70.23867063
151PRKCG0.23739676

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001006.84630647
2* Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.35592176
3Fatty acid elongation_Homo sapiens_hsa000624.35194263
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.65984023
5* Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14358710
6Ether lipid metabolism_Homo sapiens_hsa005652.48761520
7Sulfur metabolism_Homo sapiens_hsa009201.87980808
8* Butanoate metabolism_Homo sapiens_hsa006501.74462229
9Fatty acid metabolism_Homo sapiens_hsa012121.73294840
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70666145
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65686856
12Axon guidance_Homo sapiens_hsa043601.64800057
13Histidine metabolism_Homo sapiens_hsa003401.58232284
14Nitrogen metabolism_Homo sapiens_hsa009101.57518452
15Oxidative phosphorylation_Homo sapiens_hsa001901.52298875
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42058017
17Propanoate metabolism_Homo sapiens_hsa006401.39962324
18Basal cell carcinoma_Homo sapiens_hsa052171.36813472
19Non-homologous end-joining_Homo sapiens_hsa034501.27217771
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26296240
21Linoleic acid metabolism_Homo sapiens_hsa005911.23882344
22Sphingolipid metabolism_Homo sapiens_hsa006001.21361278
23Basal transcription factors_Homo sapiens_hsa030221.17291801
24Hippo signaling pathway_Homo sapiens_hsa043901.16105189
25Vitamin B6 metabolism_Homo sapiens_hsa007501.15508881
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.11358981
27Spliceosome_Homo sapiens_hsa030401.10223387
28mRNA surveillance pathway_Homo sapiens_hsa030151.09043686
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08011417
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06833301
31Parkinsons disease_Homo sapiens_hsa050121.06611900
32Fatty acid biosynthesis_Homo sapiens_hsa000611.05446105
33* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04982057
34Serotonergic synapse_Homo sapiens_hsa047261.04174474
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02756085
36Fanconi anemia pathway_Homo sapiens_hsa034601.01721835
37Cell cycle_Homo sapiens_hsa041101.00252626
38Peroxisome_Homo sapiens_hsa041460.99262965
39Alzheimers disease_Homo sapiens_hsa050100.99162525
40Pyruvate metabolism_Homo sapiens_hsa006200.99161622
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.97287260
42Mismatch repair_Homo sapiens_hsa034300.96136565
43RNA transport_Homo sapiens_hsa030130.94577439
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92306394
45Glutamatergic synapse_Homo sapiens_hsa047240.91706878
46Arginine and proline metabolism_Homo sapiens_hsa003300.91666202
47Protein export_Homo sapiens_hsa030600.89291079
48GABAergic synapse_Homo sapiens_hsa047270.88914762
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87804217
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86477322
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86305807
52Lysine degradation_Homo sapiens_hsa003100.85229688
53RNA degradation_Homo sapiens_hsa030180.83775841
54Biosynthesis of amino acids_Homo sapiens_hsa012300.83273621
55Wnt signaling pathway_Homo sapiens_hsa043100.82730347
56Oocyte meiosis_Homo sapiens_hsa041140.82666267
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.81441751
58Long-term depression_Homo sapiens_hsa047300.80522149
59Renal cell carcinoma_Homo sapiens_hsa052110.80279028
60Carbon metabolism_Homo sapiens_hsa012000.79394840
61Tight junction_Homo sapiens_hsa045300.78895819
62Collecting duct acid secretion_Homo sapiens_hsa049660.78801387
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70918751
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70772999
65Glutathione metabolism_Homo sapiens_hsa004800.70709403
66Ovarian steroidogenesis_Homo sapiens_hsa049130.70016750
67Fatty acid degradation_Homo sapiens_hsa000710.67740464
68Caffeine metabolism_Homo sapiens_hsa002320.67699031
69DNA replication_Homo sapiens_hsa030300.67233000
70Nucleotide excision repair_Homo sapiens_hsa034200.67199688
71Adherens junction_Homo sapiens_hsa045200.66963317
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66543469
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66181975
74Vibrio cholerae infection_Homo sapiens_hsa051100.65599750
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65377712
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.64161228
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63734834
78Selenocompound metabolism_Homo sapiens_hsa004500.62377666
79Homologous recombination_Homo sapiens_hsa034400.61997005
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60335584
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59468513
82Tyrosine metabolism_Homo sapiens_hsa003500.59453791
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58518822
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58481881
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58063322
86Cocaine addiction_Homo sapiens_hsa050300.57546909
87Chemical carcinogenesis_Homo sapiens_hsa052040.57036713
88Dopaminergic synapse_Homo sapiens_hsa047280.55962532
89Colorectal cancer_Homo sapiens_hsa052100.55818542
90One carbon pool by folate_Homo sapiens_hsa006700.54519985
91Amphetamine addiction_Homo sapiens_hsa050310.52801074
92Tryptophan metabolism_Homo sapiens_hsa003800.52622190
93Synaptic vesicle cycle_Homo sapiens_hsa047210.52184787
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51267890
95Hedgehog signaling pathway_Homo sapiens_hsa043400.51203921
96Retinol metabolism_Homo sapiens_hsa008300.51010767
97PPAR signaling pathway_Homo sapiens_hsa033200.50565123
98Morphine addiction_Homo sapiens_hsa050320.50329765
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49480491
100Cholinergic synapse_Homo sapiens_hsa047250.48825915
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.48739837
102TGF-beta signaling pathway_Homo sapiens_hsa043500.47793396
103ErbB signaling pathway_Homo sapiens_hsa040120.46770875
104Huntingtons disease_Homo sapiens_hsa050160.46747757
105Ras signaling pathway_Homo sapiens_hsa040140.46081252
106Circadian entrainment_Homo sapiens_hsa047130.45609835
107Taste transduction_Homo sapiens_hsa047420.44917777
108beta-Alanine metabolism_Homo sapiens_hsa004100.44415774
109Bile secretion_Homo sapiens_hsa049760.44168448
110Dorso-ventral axis formation_Homo sapiens_hsa043200.42819722
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41943208
112Fat digestion and absorption_Homo sapiens_hsa049750.41730839
113Alcoholism_Homo sapiens_hsa050340.41256135
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41055975
115* Metabolic pathways_Homo sapiens_hsa011000.40864315
116Nicotine addiction_Homo sapiens_hsa050330.40297570
117MicroRNAs in cancer_Homo sapiens_hsa052060.40243085
118Gap junction_Homo sapiens_hsa045400.38807128
119Phagosome_Homo sapiens_hsa041450.38804512
120Base excision repair_Homo sapiens_hsa034100.38794766
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38082134
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37247660
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.37111961
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36709559
125Arachidonic acid metabolism_Homo sapiens_hsa005900.36699490
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35875634
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35761477
128Cardiac muscle contraction_Homo sapiens_hsa042600.35099826
129Prion diseases_Homo sapiens_hsa050200.34075554
130Endocytosis_Homo sapiens_hsa041440.33698240
131AMPK signaling pathway_Homo sapiens_hsa041520.31667252
132ECM-receptor interaction_Homo sapiens_hsa045120.29749982
133Rheumatoid arthritis_Homo sapiens_hsa053230.28644591
134Gastric acid secretion_Homo sapiens_hsa049710.28623149
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28178039
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.27710922
137Mineral absorption_Homo sapiens_hsa049780.26744322
138Phenylalanine metabolism_Homo sapiens_hsa003600.26021909
139Salivary secretion_Homo sapiens_hsa049700.24847619
140Phototransduction_Homo sapiens_hsa047440.24216693
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24026280
142Renin secretion_Homo sapiens_hsa049240.23432615
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20287712
144Glycerolipid metabolism_Homo sapiens_hsa005610.19640191
145Choline metabolism in cancer_Homo sapiens_hsa052310.19046274
146Melanogenesis_Homo sapiens_hsa049160.18898811

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