HMGN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA topological change (GO:0006265)4.94656670
2DNA unwinding involved in DNA replication (GO:0006268)4.83852532
3DNA strand elongation involved in DNA replication (GO:0006271)4.32094002
4viral transcription (GO:0019083)4.27422288
5translational termination (GO:0006415)4.19069331
6maturation of SSU-rRNA (GO:0030490)4.18007623
7DNA ligation (GO:0006266)4.10612030
8DNA strand elongation (GO:0022616)4.08005311
9mitotic metaphase plate congression (GO:0007080)4.06423388
10DNA replication-dependent nucleosome organization (GO:0034723)4.03168223
11DNA replication-dependent nucleosome assembly (GO:0006335)4.03168223
12ribosomal small subunit assembly (GO:0000028)4.00289198
13DNA replication initiation (GO:0006270)3.98238006
14protein localization to kinetochore (GO:0034501)3.95795781
15ribosomal large subunit biogenesis (GO:0042273)3.87284386
16telomere maintenance via semi-conservative replication (GO:0032201)3.85582964
17negative regulation of mRNA metabolic process (GO:1903312)3.85329465
18paraxial mesoderm development (GO:0048339)3.84771091
19peptidyl-arginine omega-N-methylation (GO:0035247)3.80598457
20formation of translation preinitiation complex (GO:0001731)3.77999095
21translational elongation (GO:0006414)3.75708080
22establishment of viral latency (GO:0019043)3.71875853
23peptidyl-arginine N-methylation (GO:0035246)3.69596921
24peptidyl-arginine methylation (GO:0018216)3.69596921
25translational initiation (GO:0006413)3.69380282
26kinetochore organization (GO:0051383)3.68114179
27metaphase plate congression (GO:0051310)3.62708689
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62380793
29chromatin remodeling at centromere (GO:0031055)3.61480400
30mitotic nuclear envelope disassembly (GO:0007077)3.60961087
31CENP-A containing nucleosome assembly (GO:0034080)3.57723437
32mitotic recombination (GO:0006312)3.54307135
33protein-DNA complex disassembly (GO:0032986)3.52230358
34nucleosome disassembly (GO:0006337)3.52230358
35nuclear pore organization (GO:0006999)3.50018371
36telomere maintenance via recombination (GO:0000722)3.49297903
37ribosomal small subunit biogenesis (GO:0042274)3.48908217
38mRNA splice site selection (GO:0006376)3.48580659
39protein localization to chromosome, centromeric region (GO:0071459)3.45984508
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45060956
41DNA replication checkpoint (GO:0000076)3.44590295
42DNA replication-independent nucleosome assembly (GO:0006336)3.44147266
43DNA replication-independent nucleosome organization (GO:0034724)3.44147266
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.41784896
45nucleobase biosynthetic process (GO:0046112)3.39955689
46heterochromatin organization (GO:0070828)3.39908035
47nuclear envelope disassembly (GO:0051081)3.34924221
48membrane disassembly (GO:0030397)3.34924221
49kinetochore assembly (GO:0051382)3.34283633
50folic acid-containing compound biosynthetic process (GO:0009396)3.32876631
51mitotic chromosome condensation (GO:0007076)3.31543806
52spliceosomal snRNP assembly (GO:0000387)3.31222468
53protein targeting to ER (GO:0045047)3.31173782
54cotranslational protein targeting to membrane (GO:0006613)3.31046786
55histone arginine methylation (GO:0034969)3.30920207
56viral life cycle (GO:0019058)3.29453956
57cellular protein complex disassembly (GO:0043624)3.29300605
58DNA damage response, detection of DNA damage (GO:0042769)3.26406809
59telomere maintenance via telomere lengthening (GO:0010833)3.25519172
60negative regulation of RNA splicing (GO:0033119)3.25515374
61regulation of centriole replication (GO:0046599)3.21851147
62ribonucleoprotein complex biogenesis (GO:0022613)3.20785985
63purine nucleobase biosynthetic process (GO:0009113)3.18823304
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.16401225
65regulation of posttranscriptional gene silencing (GO:0060147)3.13772377
66regulation of gene silencing by miRNA (GO:0060964)3.13772377
67regulation of gene silencing by RNA (GO:0060966)3.13772377
68mitotic sister chromatid segregation (GO:0000070)3.13586926
69ribosome assembly (GO:0042255)3.12989158
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12711857
71nuclear pore complex assembly (GO:0051292)3.12136382
72regulation of spindle organization (GO:0090224)3.12046960
73establishment of chromosome localization (GO:0051303)3.11717940
74regulation of helicase activity (GO:0051095)3.11365289
75histone exchange (GO:0043486)3.11296749
76protein complex disassembly (GO:0043241)3.10756971
77non-recombinational repair (GO:0000726)3.10543270
78double-strand break repair via nonhomologous end joining (GO:0006303)3.10543270
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10418315
80negative regulation of chromosome segregation (GO:0051985)3.09671137
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07791715
82negative regulation of sister chromatid segregation (GO:0033046)3.07791715
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.07791715
84negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07791715
85sister chromatid segregation (GO:0000819)3.07656790
86mitotic sister chromatid cohesion (GO:0007064)3.06733433
87protein localization to endoplasmic reticulum (GO:0070972)3.06684607
88spindle assembly checkpoint (GO:0071173)3.06161941
89mitotic spindle assembly checkpoint (GO:0007094)3.05271549
90attachment of spindle microtubules to kinetochore (GO:0008608)3.04214519
91spindle checkpoint (GO:0031577)3.03960213
92spliceosomal complex assembly (GO:0000245)3.03667416
93establishment of integrated proviral latency (GO:0075713)3.03013110
94negative regulation of mRNA processing (GO:0050686)3.00573846
95RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.00448500
96mRNA splicing, via spliceosome (GO:0000398)3.00448500
97RNA splicing, via transesterification reactions (GO:0000375)2.99676750
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98631494
99mitotic spindle checkpoint (GO:0071174)2.98036228
100regulation of sister chromatid cohesion (GO:0007063)2.96606511
101IMP biosynthetic process (GO:0006188)2.95496450
102regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93665739
103ATP-dependent chromatin remodeling (GO:0043044)2.93198139
104DNA duplex unwinding (GO:0032508)2.93104047
105regulation of chromosome segregation (GO:0051983)2.92869979
106RNA export from nucleus (GO:0006405)2.92716845
107macromolecular complex disassembly (GO:0032984)2.92299502
108DNA geometric change (GO:0032392)2.91754129
109nuclear-transcribed mRNA catabolic process (GO:0000956)2.91382833
110V(D)J recombination (GO:0033151)2.90679093
111chromatin assembly or disassembly (GO:0006333)2.90527893
112somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90307790
113somatic hypermutation of immunoglobulin genes (GO:0016446)2.90307790
114ribosome biogenesis (GO:0042254)2.89770767
115base-excision repair (GO:0006284)2.89657197
116L-serine metabolic process (GO:0006563)2.88999062
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88559460
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86908432
119regulation of mRNA splicing, via spliceosome (GO:0048024)2.86762597
120RNA stabilization (GO:0043489)2.86277056
121mRNA stabilization (GO:0048255)2.86277056
122mRNA export from nucleus (GO:0006406)2.85269011
123regulation of centrosome cycle (GO:0046605)2.85264820
124viral mRNA export from host cell nucleus (GO:0046784)2.85063089
125regulation of histone H3-K9 methylation (GO:0051570)2.84128901
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.83882237
127pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83738389
128mRNA 3-end processing (GO:0031124)2.82583687
129termination of RNA polymerase II transcription (GO:0006369)2.82254275
130rRNA processing (GO:0006364)2.80567030
131RNA splicing (GO:0008380)2.79001722
132ribonucleoprotein complex assembly (GO:0022618)2.77967838
133alternative mRNA splicing, via spliceosome (GO:0000380)2.75208194
134regulation of mRNA stability (GO:0043488)2.74764204
135positive regulation of RNA splicing (GO:0033120)2.73868530
136pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73284235
137ribonucleoprotein complex subunit organization (GO:0071826)2.72884143
138regulation of translational fidelity (GO:0006450)2.72743433
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72605796
140regulation of double-strand break repair via homologous recombination (GO:0010569)2.69281071
141protein localization to chromosome (GO:0034502)2.65959160
142regulation of transcription from RNA polymerase I promoter (GO:0006356)2.64761506
143RNA 3-end processing (GO:0031123)2.64394481
144mRNA transport (GO:0051028)2.64068642
145DNA conformation change (GO:0071103)2.62121219
146histone H2B ubiquitination (GO:0033523)2.61837913
147translesion synthesis (GO:0019985)2.60311895
148DNA double-strand break processing (GO:0000729)2.59870853
149DNA-templated transcription, termination (GO:0006353)2.57304658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.82243475
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.64351702
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.54038058
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84182179
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47866660
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45975952
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24857488
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90235519
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73309123
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69889641
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.61825438
12XRN2_22483619_ChIP-Seq_HELA_Human2.56168657
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.50114269
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49337677
15AR_21909140_ChIP-Seq_LNCAP_Human2.40661212
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.40271973
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39131857
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30217444
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29407534
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22530738
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21251309
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13312835
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07222887
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.05100703
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01704470
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.99494376
27TTF2_22483619_ChIP-Seq_HELA_Human1.99423075
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96009561
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.93690236
30DCP1A_22483619_ChIP-Seq_HELA_Human1.89782823
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89228317
32VDR_23849224_ChIP-Seq_CD4+_Human1.82808752
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79152693
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77655099
35* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74095008
36* GABP_19822575_ChIP-Seq_HepG2_Human1.73564652
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.73227888
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70441169
39FOXP3_21729870_ChIP-Seq_TREG_Human1.66002932
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62477200
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62434515
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61395273
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59291400
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59252606
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55157176
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55146545
47* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54433284
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54226960
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54178639
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53094428
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52872121
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52152125
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50803025
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49302112
55CIITA_25753668_ChIP-Seq_RAJI_Human1.48299887
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46495291
57ELK1_19687146_ChIP-ChIP_HELA_Human1.46471380
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42679847
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36448464
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.35605403
61KDM5A_27292631_Chip-Seq_BREAST_Human1.35486980
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34596839
63MYC_22102868_ChIP-Seq_BL_Human1.32562921
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30902394
65IRF1_19129219_ChIP-ChIP_H3396_Human1.30615228
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29713527
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27237694
68EWS_26573619_Chip-Seq_HEK293_Human1.25932558
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23068889
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22142848
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21791700
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19526940
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19526940
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19526940
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18557500
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.18091035
77* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17699833
78* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.16012076
79IGF1R_20145208_ChIP-Seq_DFB_Human1.14082997
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13682498
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13616022
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.11824942
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.11640065
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11621853
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11517001
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09891987
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06665360
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05951476
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05917244
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05752046
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03912896
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.02701693
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02028055
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.01881468
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01564320
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00577584
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99208651
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99090664
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98137593
100TFEB_21752829_ChIP-Seq_HELA_Human0.97711778
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97104607
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.96718058
103SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96342374
104ZNF263_19887448_ChIP-Seq_K562_Human0.95963305
105* MYC_18940864_ChIP-ChIP_HL60_Human0.95676891
106TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95652819
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95000683
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94532733
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93675297
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93406154
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93091690
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92710339
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91196861
114CHD1_26751641_Chip-Seq_LNCaP_Human0.87912341
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87199646
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.86809565
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.86354817
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85736940
119* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85619407
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84672507
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84672042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.01336140
2MP0004957_abnormal_blastocyst_morpholog3.60663435
3MP0010030_abnormal_orbit_morphology3.42465162
4MP0003111_abnormal_nucleus_morphology3.34481684
5MP0010094_abnormal_chromosome_stability3.31897112
6* MP0003077_abnormal_cell_cycle3.06714761
7MP0003123_paternal_imprinting2.79005988
8MP0008932_abnormal_embryonic_tissue2.47973263
9MP0000537_abnormal_urethra_morphology2.39821407
10MP0008007_abnormal_cellular_replicative2.38924166
11MP0008058_abnormal_DNA_repair2.27092626
12MP0008057_abnormal_DNA_replication2.21606440
13MP0009053_abnormal_anal_canal2.15610477
14MP0001730_embryonic_growth_arrest2.09098602
15MP0002877_abnormal_melanocyte_morpholog2.05388055
16MP0010352_gastrointestinal_tract_polyps1.99766292
17MP0005499_abnormal_olfactory_system1.98053357
18MP0005394_taste/olfaction_phenotype1.98053357
19* MP0000350_abnormal_cell_proliferation1.90281655
20MP0003315_abnormal_perineum_morphology1.81091641
21MP0003890_abnormal_embryonic-extraembry1.80295641
22MP0003119_abnormal_digestive_system1.75077163
23MP0002085_abnormal_embryonic_tissue1.73306216
24MP0001188_hyperpigmentation1.72315041
25MP0003121_genomic_imprinting1.71932972
26MP0003941_abnormal_skin_development1.71377108
27MP0001697_abnormal_embryo_size1.67248751
28MP0002084_abnormal_developmental_patter1.66754858
29MP0003221_abnormal_cardiomyocyte_apopto1.65013021
30MP0005380_embryogenesis_phenotype1.64994233
31MP0001672_abnormal_embryogenesis/_devel1.64994233
32MP0001293_anophthalmia1.64618687
33MP0002009_preneoplasia1.62893712
34MP0003705_abnormal_hypodermis_morpholog1.60067600
35MP0003937_abnormal_limbs/digits/tail_de1.58055301
36MP0002653_abnormal_ependyma_morphology1.57783494
37MP0004197_abnormal_fetal_growth/weight/1.55341283
38MP0000778_abnormal_nervous_system1.55164758
39MP0001529_abnormal_vocalization1.55141075
40MP0008995_early_reproductive_senescence1.53806046
41MP0003011_delayed_dark_adaptation1.52414975
42MP0000566_synostosis1.51156518
43MP0003567_abnormal_fetal_cardiomyocyte1.46203092
44MP0003984_embryonic_growth_retardation1.46193118
45MP0002088_abnormal_embryonic_growth/wei1.45096763
46MP0004133_heterotaxia1.44092755
47MP0000049_abnormal_middle_ear1.43792194
48MP0005076_abnormal_cell_differentiation1.40672159
49* MP0002080_prenatal_lethality1.39166098
50MP0008877_abnormal_DNA_methylation1.36322421
51MP0002086_abnormal_extraembryonic_tissu1.29444960
52MP0003942_abnormal_urinary_system1.28336822
53MP0009697_abnormal_copulation1.24205141
54MP0003786_premature_aging1.24121773
55MP0006072_abnormal_retinal_apoptosis1.23255168
56MP0002111_abnormal_tail_morphology1.23019790
57MP0001286_abnormal_eye_development1.22962163
58MP0000428_abnormal_craniofacial_morphol1.22947334
59MP0002938_white_spotting1.21878204
60MP0006292_abnormal_olfactory_placode1.20609083
61MP0003385_abnormal_body_wall1.19537880
62MP0002282_abnormal_trachea_morphology1.19186068
63MP0008789_abnormal_olfactory_epithelium1.19174516
64MP0002249_abnormal_larynx_morphology1.13900928
65MP0002932_abnormal_joint_morphology1.13707581
66MP0001727_abnormal_embryo_implantation1.13222040
67MP0003755_abnormal_palate_morphology1.13129397
68MP0003935_abnormal_craniofacial_develop1.12348290
69MP0002751_abnormal_autonomic_nervous1.11394107
70MP0009379_abnormal_foot_pigmentation1.10794256
71MP0002697_abnormal_eye_size1.09168313
72MP0006054_spinal_hemorrhage1.06633701
73MP0002092_abnormal_eye_morphology1.06313016
74MP0003115_abnormal_respiratory_system1.06091565
75MP0004147_increased_porphyrin_level1.04997382
76MP0003283_abnormal_digestive_organ1.04182088
77MP0000490_abnormal_crypts_of1.01001168
78MP0000432_abnormal_head_morphology1.00239766
79MP0010307_abnormal_tumor_latency0.99693737
80* MP0000313_abnormal_cell_death0.96939105
81MP0002234_abnormal_pharynx_morphology0.96936463
82MP0003718_maternal_effect0.96803824
83MP0005391_vision/eye_phenotype0.96704619
84MP0002081_perinatal_lethality0.96443811
85MP0000358_abnormal_cell_content/0.96428570
86MP0002233_abnormal_nose_morphology0.96261632
87MP0009672_abnormal_birth_weight0.96173608
88MP0000762_abnormal_tongue_morphology0.96062642
89MP0009250_abnormal_appendicular_skeleto0.95418418
90MP0002210_abnormal_sex_determination0.94016560
91MP0003122_maternal_imprinting0.93456448
92MP0002098_abnormal_vibrissa_morphology0.93201448
93MP0004811_abnormal_neuron_physiology0.90910067
94MP0006035_abnormal_mitochondrial_morpho0.90592707
95MP0002160_abnormal_reproductive_system0.89384318
96MP0000631_abnormal_neuroendocrine_gland0.87137632
97MP0002152_abnormal_brain_morphology0.86149162
98MP0001346_abnormal_lacrimal_gland0.85186387
99MP0000534_abnormal_ureter_morphology0.84803517
100MP0001984_abnormal_olfaction0.84308398
101MP0002116_abnormal_craniofacial_bone0.84120596
102MP0000647_abnormal_sebaceous_gland0.83940005
103* MP0002019_abnormal_tumor_incidence0.83915169
104MP0001849_ear_inflammation0.83767633
105MP0000733_abnormal_muscle_development0.82943295
106MP0003861_abnormal_nervous_system0.81273750
107MP0002736_abnormal_nociception_after0.80654327
108MP0005023_abnormal_wound_healing0.80552343
109MP0001145_abnormal_male_reproductive0.80467897
110MP0001915_intracranial_hemorrhage0.78664086
111MP0005275_abnormal_skin_tensile0.78529160
112MP0003938_abnormal_ear_development0.78298460
113MP0004808_abnormal_hematopoietic_stem0.78191331
114MP0001299_abnormal_eye_distance/0.78100530
115MP0000955_abnormal_spinal_cord0.78084850
116MP0002184_abnormal_innervation0.77855092
117MP0003787_abnormal_imprinting0.77467165
118MP0001929_abnormal_gametogenesis0.76999404
119MP0005253_abnormal_eye_physiology0.76366717
120MP0004272_abnormal_basement_membrane0.76288111
121MP0002102_abnormal_ear_morphology0.76214402
122MP0002114_abnormal_axial_skeleton0.75638678
123MP0003136_yellow_coat_color0.75170461
124MP0005503_abnormal_tendon_morphology0.75154011
125MP0009703_decreased_birth_body0.74882661
126MP0005257_abnormal_intraocular_pressure0.74325417
127MP0002177_abnormal_outer_ear0.73792019
128MP0002396_abnormal_hematopoietic_system0.73622434
129MP0005248_abnormal_Harderian_gland0.73165438
130MP0005187_abnormal_penis_morphology0.71314141

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.72395666
2Colon cancer (HP:0003003)4.15296435
3Reticulocytopenia (HP:0001896)4.08627506
4Selective tooth agenesis (HP:0001592)3.21818237
5Medulloblastoma (HP:0002885)3.04643492
6Ependymoma (HP:0002888)3.02615640
7Patellar aplasia (HP:0006443)3.01421419
8Birth length less than 3rd percentile (HP:0003561)3.01294306
9Breast hypoplasia (HP:0003187)3.00466118
10Aplasia/Hypoplasia of the patella (HP:0006498)2.90215996
11Spastic diplegia (HP:0001264)2.87220879
12Abnormality of cells of the erythroid lineage (HP:0012130)2.75542791
13Pendular nystagmus (HP:0012043)2.71118701
14Oral leukoplakia (HP:0002745)2.69828269
15Shoulder girdle muscle weakness (HP:0003547)2.60014051
16Trismus (HP:0000211)2.58529560
17Abnormal number of incisors (HP:0011064)2.49666619
18Rectal prolapse (HP:0002035)2.48070940
19Absent radius (HP:0003974)2.47397522
20Atresia of the external auditory canal (HP:0000413)2.46652551
21Abnormal number of erythroid precursors (HP:0012131)2.44063107
22Neoplasm of the pancreas (HP:0002894)2.43596612
23Short 4th metacarpal (HP:0010044)2.38738004
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.38738004
25Abnormality of the anterior horn cell (HP:0006802)2.38632939
26Degeneration of anterior horn cells (HP:0002398)2.38632939
27Missing ribs (HP:0000921)2.38585308
28Volvulus (HP:0002580)2.37709391
2911 pairs of ribs (HP:0000878)2.35745276
30Renal duplication (HP:0000075)2.33941621
31Macrocytic anemia (HP:0001972)2.33754344
32Congenital stationary night blindness (HP:0007642)2.33285605
33Absent thumb (HP:0009777)2.31998555
34Meckel diverticulum (HP:0002245)2.31745532
35Chromsome breakage (HP:0040012)2.30711664
36Absent forearm bone (HP:0003953)2.30169480
37Aplasia involving forearm bones (HP:0009822)2.30169480
38Abdominal situs inversus (HP:0003363)2.28682300
39Abnormality of abdominal situs (HP:0011620)2.28682300
40Multiple enchondromatosis (HP:0005701)2.28458937
41Abnormal lung lobation (HP:0002101)2.27642439
42Rhabdomyosarcoma (HP:0002859)2.26757486
43Pallor (HP:0000980)2.26267974
44Supernumerary spleens (HP:0009799)2.25616139
45Microvesicular hepatic steatosis (HP:0001414)2.23284509
46Increased nuchal translucency (HP:0010880)2.20280304
47Abnormality of the ileum (HP:0001549)2.19034760
48Proximal placement of thumb (HP:0009623)2.15394683
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12796420
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12744696
51Termporal pattern (HP:0011008)2.12256386
52Insidious onset (HP:0003587)2.12256386
53Deviation of the thumb (HP:0009603)2.12242502
54Biliary tract neoplasm (HP:0100574)2.08578325
55Chorioretinal atrophy (HP:0000533)2.08506190
56Rough bone trabeculation (HP:0100670)2.06435309
57Triphalangeal thumb (HP:0001199)2.05733522
58Retinal dysplasia (HP:0007973)2.05732065
59Irregular epiphyses (HP:0010582)2.05466829
60Abnormality of the musculature of the pelvis (HP:0001469)2.03664228
61Abnormality of the hip-girdle musculature (HP:0001445)2.03664228
62Astrocytoma (HP:0009592)2.03190567
63Abnormality of the astrocytes (HP:0100707)2.03190567
64Microretrognathia (HP:0000308)1.99246314
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.98555578
66Carpal bone hypoplasia (HP:0001498)1.97830155
67Abnormality of the labia minora (HP:0012880)1.97808352
68Facial cleft (HP:0002006)1.97684623
69Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96780794
70Duodenal stenosis (HP:0100867)1.95503028
71Small intestinal stenosis (HP:0012848)1.95503028
72Abnormality of the preputium (HP:0100587)1.95117804
73Neoplasm of the colon (HP:0100273)1.94658017
74Horseshoe kidney (HP:0000085)1.93390156
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.92362575
76Abnormality of the carotid arteries (HP:0005344)1.91962244
77Rib fusion (HP:0000902)1.90620655
78Bony spicule pigmentary retinopathy (HP:0007737)1.89964490
79Protrusio acetabuli (HP:0003179)1.89824201
80Abnormality of chromosome stability (HP:0003220)1.89624165
81Neoplasm of striated muscle (HP:0009728)1.88193575
82Malignant gastrointestinal tract tumors (HP:0006749)1.86633190
83Gastrointestinal carcinoma (HP:0002672)1.86633190
84Sex reversal (HP:0012245)1.86144259
85Abnormal sex determination (HP:0012244)1.86144259
86Hemivertebrae (HP:0002937)1.85946194
87Hyperglycinemia (HP:0002154)1.85697749
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.85155984
89Morphological abnormality of the middle ear (HP:0008609)1.84702737
90Ectopic kidney (HP:0000086)1.84629823
91Hepatoblastoma (HP:0002884)1.84378572
92Glioma (HP:0009733)1.84325481
93Esophageal atresia (HP:0002032)1.82605928
94Tracheoesophageal fistula (HP:0002575)1.82509002
95Overlapping toe (HP:0001845)1.81399739
96Abnormality of the 4th metacarpal (HP:0010012)1.80490077
97Breech presentation (HP:0001623)1.77885648
98Short middle phalanx of the 5th finger (HP:0004220)1.77859585
99Postnatal microcephaly (HP:0005484)1.77333389
100Abnormality of the duodenum (HP:0002246)1.77091573
101Posterior subcapsular cataract (HP:0007787)1.76967241
102Glossoptosis (HP:0000162)1.76925109
103Myelodysplasia (HP:0002863)1.75706741
104Abnormality of glycolysis (HP:0004366)1.75062295
105Impulsivity (HP:0100710)1.74786606
106Preauricular skin tag (HP:0000384)1.74594064
107Aplasia/hypoplasia of the humerus (HP:0006507)1.74484626
108Pelvic girdle muscle weakness (HP:0003749)1.74288377
109Nephroblastoma (Wilms tumor) (HP:0002667)1.73618473
110Stenosis of the external auditory canal (HP:0000402)1.73227967
111Short 5th finger (HP:0009237)1.72759303
112Ovarian neoplasm (HP:0100615)1.72660371
113Absent eyebrow (HP:0002223)1.72319500
114High anterior hairline (HP:0009890)1.70821584
115Shawl scrotum (HP:0000049)1.70488953
116Abnormal hemoglobin (HP:0011902)1.70233038
117Oligodactyly (HP:0012165)1.69991622
118Calcaneovalgus deformity (HP:0001848)1.69754040
119Aplastic anemia (HP:0001915)1.69722651
120Lissencephaly (HP:0001339)1.68789331
121Embryonal renal neoplasm (HP:0011794)1.68610734
122Optic nerve coloboma (HP:0000588)1.68401930
123Angiofibromas (HP:0010615)1.68105696
124Adenoma sebaceum (HP:0009720)1.68105696
125Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68080380
126Failure to thrive in infancy (HP:0001531)1.67921515
127Premature graying of hair (HP:0002216)1.67769389
128Breast carcinoma (HP:0003002)1.66776228
129Broad foot (HP:0001769)1.65927327
130Abnormality of the calcaneus (HP:0008364)1.64495334
131Coarctation of aorta (HP:0001680)1.63752544
132Partial agenesis of the corpus callosum (HP:0001338)1.63651244
133Increased serum pyruvate (HP:0003542)1.62454294
134Drooling (HP:0002307)1.60866475
135Unilateral renal agenesis (HP:0000122)1.59636764
136Sloping forehead (HP:0000340)1.59355695
137Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.59347285
138Trigonocephaly (HP:0000243)1.58703894
139Hypoplastic pelvis (HP:0008839)1.57610298
140Aplasia/Hypoplasia of the brainstem (HP:0007362)1.56796872
141Hypoplasia of the brainstem (HP:0002365)1.56796872
142Vitreoretinal degeneration (HP:0000655)1.56103871
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.55787427
144Overriding aorta (HP:0002623)1.54213040
145Obsessive-compulsive behavior (HP:0000722)1.53835855
146Amyotrophic lateral sclerosis (HP:0007354)1.52721234
147Bifid tongue (HP:0010297)1.51408050
148Generalized hypotonia (HP:0001290)1.50320423
149Preaxial hand polydactyly (HP:0001177)1.49795774
150Broad distal phalanx of finger (HP:0009836)1.48914796
151Radioulnar synostosis (HP:0002974)1.48611511
152Abnormality of reticulocytes (HP:0004312)1.47911452
153Micropenis (HP:0000054)1.47819747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.42005115
2CDC73.86338158
3WEE13.72479687
4EIF2AK12.89393656
5NEK22.68464542
6SRPK12.59676612
7ACVR1B2.46816643
8TTK2.46139452
9TLK12.01529508
10NEK12.01292214
11MKNK12.01204470
12TRIM281.96812055
13DYRK31.95714387
14PLK11.95376874
15MAP3K41.93379781
16PASK1.89712280
17EPHA21.89288264
18PLK41.87862460
19RPS6KB21.87406726
20MAP2K71.85615017
21MAP3K101.77904166
22AURKB1.76684734
23CDK71.75611103
24VRK21.75608228
25TGFBR11.71895650
26TESK21.68417382
27CDK121.67536585
28BRSK21.66396458
29NME21.65407570
30PBK1.57737247
31CDK191.57024977
32ATR1.51861284
33PAK41.51548005
34PLK31.51105435
35TNIK1.46192344
36VRK11.43914743
37STK38L1.43379778
38CHEK21.42563492
39CSNK1G21.40597822
40LATS11.40301047
41MKNK21.39655052
42AURKA1.39174993
43CSNK1G31.33541257
44MAP3K81.32576484
45BRSK11.27245461
46LATS21.25958592
47CDK41.24124760
48CSNK1A1L1.21441424
49CHEK11.19337328
50TSSK61.17454498
51EEF2K1.16768539
52EIF2AK31.15739492
53TAF11.15435803
54BRD41.15335810
55STK101.14058916
56TESK11.13997704
57BCKDK1.13738869
58SCYL21.10529461
59STK161.09004395
60CSNK1G11.05973238
61EPHB21.04844922
62CDK61.01778649
63MAP4K20.98481234
64MELK0.96628391
65PKN20.92837890
66LRRK20.92820656
67CDK140.91865970
68CDK180.90614089
69CDK11A0.90510636
70SIK30.89252999
71CDK150.83334680
72ATM0.83218347
73CDK20.82137837
74FGFR10.81070626
75MARK10.80461834
76NTRK10.79287883
77STK40.79054997
78ZAK0.76286900
79CCNB10.74730213
80CASK0.74422961
81CLK10.72652489
82STK30.72467847
83MAPKAPK30.71419989
84UHMK10.70484818
85CDK80.69029967
86KDR0.66610891
87PAK10.66599140
88PRKCI0.66283598
89ERBB30.65827599
90DYRK20.65286147
91CDK10.63794448
92SMG10.62826679
93CDK30.60622092
94CSNK2A20.60313682
95* CSNK2A10.59764621
96MTOR0.58155528
97ERBB20.57655788
98NUAK10.57313959
99LIMK10.55790828
100MINK10.55432551
101DYRK1B0.55156596
102EIF2AK20.55121375
103MAP3K110.54269813
104AKT20.54188506
105WNK30.53440945
106NTRK20.50617831
107BRAF0.49403710
108ILK0.48964696
109SIK20.48551056
110PAK20.47870104
111CDK90.46330884
112CSNK1E0.45881061
113TAOK20.43081209
114FLT30.42878069
115PDGFRA0.42823276
116MAP3K30.42473437
117NME10.41788523
118PLK20.41374081
119MET0.40326885
120* RPS6KA40.40325111
121NEK90.39874843
122ALK0.39815919
123DDR20.39073136
124MAPK90.38523072
125CSNK1D0.37883555
126YES10.37771612
127BCR0.37013822
128PRKDC0.36722334
129KSR10.36604575
130PTK60.33738744
131DAPK10.32094233
132PIM10.31224136
133PNCK0.28835889
134TRIB30.28523947
135GRK10.28310649

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74352776
2Mismatch repair_Homo sapiens_hsa034304.23920001
3Ribosome_Homo sapiens_hsa030103.90297042
4Spliceosome_Homo sapiens_hsa030403.84968410
5RNA transport_Homo sapiens_hsa030133.17932583
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14907049
7Base excision repair_Homo sapiens_hsa034102.95523453
8Cell cycle_Homo sapiens_hsa041102.94263300
9Homologous recombination_Homo sapiens_hsa034402.91376657
10Nucleotide excision repair_Homo sapiens_hsa034202.87935511
11Proteasome_Homo sapiens_hsa030502.78959397
12RNA polymerase_Homo sapiens_hsa030202.71405499
13One carbon pool by folate_Homo sapiens_hsa006702.48164655
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36150310
15Pyrimidine metabolism_Homo sapiens_hsa002402.24112958
16Fanconi anemia pathway_Homo sapiens_hsa034602.09562869
17mRNA surveillance pathway_Homo sapiens_hsa030152.01502447
18RNA degradation_Homo sapiens_hsa030181.88165265
19Phototransduction_Homo sapiens_hsa047441.80434607
20p53 signaling pathway_Homo sapiens_hsa041151.78973677
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71754500
22Basal transcription factors_Homo sapiens_hsa030221.68173133
23Non-homologous end-joining_Homo sapiens_hsa034501.55131778
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51517019
25Basal cell carcinoma_Homo sapiens_hsa052171.50687550
26Systemic lupus erythematosus_Homo sapiens_hsa053221.46254075
27Hippo signaling pathway_Homo sapiens_hsa043901.33874811
28Steroid biosynthesis_Homo sapiens_hsa001001.30821237
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30537716
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22829940
31Purine metabolism_Homo sapiens_hsa002301.14129107
32Hedgehog signaling pathway_Homo sapiens_hsa043401.10826625
33Epstein-Barr virus infection_Homo sapiens_hsa051691.09614774
34Oocyte meiosis_Homo sapiens_hsa041141.06637934
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05642350
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03994058
37Fatty acid elongation_Homo sapiens_hsa000621.03816472
38MicroRNAs in cancer_Homo sapiens_hsa052061.03475083
39TGF-beta signaling pathway_Homo sapiens_hsa043501.00279851
40Viral carcinogenesis_Homo sapiens_hsa052031.00141272
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97524534
42Small cell lung cancer_Homo sapiens_hsa052220.97132426
43HTLV-I infection_Homo sapiens_hsa051660.96267971
44Parkinsons disease_Homo sapiens_hsa050120.92421617
45Pyruvate metabolism_Homo sapiens_hsa006200.91639595
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91523798
47Bladder cancer_Homo sapiens_hsa052190.88333057
48Thyroid cancer_Homo sapiens_hsa052160.84639148
49Adherens junction_Homo sapiens_hsa045200.80916793
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78436914
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77019568
52Notch signaling pathway_Homo sapiens_hsa043300.76617628
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76533862
54Selenocompound metabolism_Homo sapiens_hsa004500.74636161
55Propanoate metabolism_Homo sapiens_hsa006400.70648552
56Alcoholism_Homo sapiens_hsa050340.69745310
57* Herpes simplex infection_Homo sapiens_hsa051680.69223885
58Folate biosynthesis_Homo sapiens_hsa007900.68314856
59Colorectal cancer_Homo sapiens_hsa052100.68121556
60Biosynthesis of amino acids_Homo sapiens_hsa012300.66528291
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65904679
62Oxidative phosphorylation_Homo sapiens_hsa001900.65667968
63Wnt signaling pathway_Homo sapiens_hsa043100.65046735
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.58976775
65Tight junction_Homo sapiens_hsa045300.58886916
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57927815
67Pathways in cancer_Homo sapiens_hsa052000.56993452
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56916920
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.56435551
70Axon guidance_Homo sapiens_hsa043600.56308760
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.56109318
72Antigen processing and presentation_Homo sapiens_hsa046120.55046148
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54133041
74Nicotine addiction_Homo sapiens_hsa050330.52161542
75Proteoglycans in cancer_Homo sapiens_hsa052050.51856330
76Chronic myeloid leukemia_Homo sapiens_hsa052200.51281859
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48973929
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48813184
79Sulfur relay system_Homo sapiens_hsa041220.48368657
80Protein export_Homo sapiens_hsa030600.46078209
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45287713
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44401522
83Glutathione metabolism_Homo sapiens_hsa004800.42895819
84Melanoma_Homo sapiens_hsa052180.41436279
85Prostate cancer_Homo sapiens_hsa052150.39170298
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.38274750
87Huntingtons disease_Homo sapiens_hsa050160.37829347
88Fatty acid metabolism_Homo sapiens_hsa012120.36867929
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36684206
90N-Glycan biosynthesis_Homo sapiens_hsa005100.35556211
91ECM-receptor interaction_Homo sapiens_hsa045120.35276311
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33638737
93Metabolic pathways_Homo sapiens_hsa011000.33171612
94Pentose phosphate pathway_Homo sapiens_hsa000300.32949708
95Apoptosis_Homo sapiens_hsa042100.32731842
96Butanoate metabolism_Homo sapiens_hsa006500.32699837
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32326687
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32010579
99Legionellosis_Homo sapiens_hsa051340.31775546
100Fructose and mannose metabolism_Homo sapiens_hsa000510.30053660
101Endometrial cancer_Homo sapiens_hsa052130.29594991
102Alzheimers disease_Homo sapiens_hsa050100.29257881
103Shigellosis_Homo sapiens_hsa051310.27319885
104Carbon metabolism_Homo sapiens_hsa012000.26310703
105Lysine degradation_Homo sapiens_hsa003100.26288309
106mTOR signaling pathway_Homo sapiens_hsa041500.24648390
107Hepatitis B_Homo sapiens_hsa051610.24481590
108Viral myocarditis_Homo sapiens_hsa054160.22663764
109HIF-1 signaling pathway_Homo sapiens_hsa040660.22367290
110AMPK signaling pathway_Homo sapiens_hsa041520.22356358
111Gap junction_Homo sapiens_hsa045400.22161625
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19336266
113Focal adhesion_Homo sapiens_hsa045100.19150517
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18802240
115Renin-angiotensin system_Homo sapiens_hsa046140.17468265
116Pancreatic cancer_Homo sapiens_hsa052120.16247487
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16066977
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14509335
119Renal cell carcinoma_Homo sapiens_hsa052110.14201900
120Non-small cell lung cancer_Homo sapiens_hsa052230.13618254
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13103696
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12559786
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12145041
124FoxO signaling pathway_Homo sapiens_hsa040680.11941631
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11624027
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.11230001
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.09984613
128Galactose metabolism_Homo sapiens_hsa000520.09304381
129Melanogenesis_Homo sapiens_hsa049160.07980231
130Acute myeloid leukemia_Homo sapiens_hsa052210.07640103
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.06275866
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.05652407

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