ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	4.75400659
2	DNA deamination (GO:0045006)	4.46822151
3	L-fucose metabolic process (GO:0042354)	4.04695975
4	L-fucose catabolic process (GO:0042355)	4.04695975
5	fucose catabolic process (GO:0019317)	4.04695975
6	indole-containing compound catabolic process (GO:0042436)	3.98541336
7	indolalkylamine catabolic process (GO:0046218)	3.98541336
8	tryptophan catabolic process (GO:0006569)	3.98541336
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.62206320
10	response to pheromone (GO:0019236)	3.55093837
11	retinal cone cell development (GO:0046549)	3.48267720
12	preassembly of GPI anchor in ER membrane (GO:0016254)	3.47657345
13	S-adenosylmethionine metabolic process (GO:0046500)	3.46214571
14	piRNA metabolic process (GO:0034587)	3.45947331
15	indolalkylamine metabolic process (GO:0006586)	3.39298585
16	platelet dense granule organization (GO:0060155)	3.37274913
17	kynurenine metabolic process (GO:0070189)	3.36377266
18	sleep (GO:0030431)	3.31164058
19	tryptophan metabolic process (GO:0006568)	3.30224017
20	regulation of microtubule-based movement (GO:0060632)	3.27167589
21	protein-cofactor linkage (GO:0018065)	3.18638827
22	protein localization to cilium (GO:0061512)	3.16928123
23	behavioral response to nicotine (GO:0035095)	3.12966095
24	protein K11-linked deubiquitination (GO:0035871)	3.08069130
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.07109141
26	mannosylation (GO:0097502)	3.06386908
27	auditory receptor cell stereocilium organization (GO:0060088)	2.99114281
28	cellular biogenic amine catabolic process (GO:0042402)	2.98065055
29	amine catabolic process (GO:0009310)	2.98065055
30	inositol phosphate catabolic process (GO:0071545)	2.96206269
31	cilium morphogenesis (GO:0060271)	2.95360367
32	cellular ketone body metabolic process (GO:0046950)	2.95085102
33	positive regulation of mitochondrial fission (GO:0090141)	2.88984106
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.82496012
35	GPI anchor metabolic process (GO:0006505)	2.81155104
36	axoneme assembly (GO:0035082)	2.79184636
37	nonmotile primary cilium assembly (GO:0035058)	2.78883654
38	cytidine metabolic process (GO:0046087)	2.78460098
39	cytidine catabolic process (GO:0006216)	2.78460098
40	cytidine deamination (GO:0009972)	2.78460098
41	mitotic cell cycle arrest (GO:0071850)	2.78087617
42	C-terminal protein lipidation (GO:0006501)	2.76302692
43	neuronal action potential propagation (GO:0019227)	2.73345741
44	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70963644
45	ketone body metabolic process (GO:1902224)	2.68684953
46	detection of light stimulus involved in sensory perception (GO:0050962)	2.68182749
47	detection of light stimulus involved in visual perception (GO:0050908)	2.68182749
48	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.67784554
49	multicellular organism reproduction (GO:0032504)	2.65086210
50	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.64929704
51	inositol phosphate dephosphorylation (GO:0046855)	2.64929704
52	dopamine transport (GO:0015872)	2.63424853
53	C4-dicarboxylate transport (GO:0015740)	2.63379627
54	regulation of memory T cell differentiation (GO:0043380)	2.60791770
55	rhodopsin mediated signaling pathway (GO:0016056)	2.60662834
56	photoreceptor cell development (GO:0042461)	2.60419661
57	positive regulation of prostaglandin secretion (GO:0032308)	2.60194445
58	indole-containing compound metabolic process (GO:0042430)	2.59074715
59	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.58943198
60	respiratory chain complex IV assembly (GO:0008535)	2.58454257
61	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.57978875
62	adenosine metabolic process (GO:0046085)	2.57628134
63	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.57366159
64	aromatic amino acid family catabolic process (GO:0009074)	2.57362847
65	C-terminal protein amino acid modification (GO:0018410)	2.56345287
66	hindbrain development (GO:0030902)	2.54247415
67	anterograde synaptic vesicle transport (GO:0048490)	2.54007594
68	sulfation (GO:0051923)	2.52430920
69	protein K6-linked ubiquitination (GO:0085020)	2.52275442
70	DNA double-strand break processing (GO:0000729)	2.52272648
71	proline transport (GO:0015824)	2.50783093
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50154683
73	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50154683
74	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.49943246
75	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.49348320
76	polyol catabolic process (GO:0046174)	2.49107751
77	DNA methylation involved in gamete generation (GO:0043046)	2.48528363
78	neural tube formation (GO:0001841)	2.48239340
79	negative regulation by host of viral transcription (GO:0043922)	2.47252297
80	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.46537924
81	negative regulation of mast cell activation (GO:0033004)	2.44566401
82	inner ear receptor stereocilium organization (GO:0060122)	2.43321967
83	negative regulation of telomere maintenance (GO:0032205)	2.43197803
84	eye photoreceptor cell development (GO:0042462)	2.41648671
85	regulation of neurotransmitter uptake (GO:0051580)	2.41631299
86	amino acid salvage (GO:0043102)	2.40004149
87	L-methionine salvage (GO:0071267)	2.40004149
88	L-methionine biosynthetic process (GO:0071265)	2.40004149
89	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.39417349
90	regulation of mitotic spindle checkpoint (GO:1903504)	2.39304364
91	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.39304364
92	benzene-containing compound metabolic process (GO:0042537)	2.38176187
93	magnesium ion transport (GO:0015693)	2.37635615
94	rRNA catabolic process (GO:0016075)	2.37546786
95	epithelial cilium movement (GO:0003351)	2.35656968
96	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.35623206
97	cilium or flagellum-dependent cell motility (GO:0001539)	2.35536951
98	photoreceptor cell maintenance (GO:0045494)	2.34966809
99	tRNA processing (GO:0008033)	2.34682184
100	ribonucleoprotein complex disassembly (GO:0032988)	2.31814723

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.04298116
2	IGF1R_20145208_ChIP-Seq_DFB_Human	2.95359877
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.91066388
4	VDR_22108803_ChIP-Seq_LS180_Human	2.79795384
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.67200752
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65053961
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.61906380
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60949403
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54515577
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.39301261
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22816748
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21699393
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.19860786
14	FUS_26573619_Chip-Seq_HEK293_Human	2.14577146
15	P300_19829295_ChIP-Seq_ESCs_Human	2.11161767
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05185804
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03627750
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.96612068
19	EWS_26573619_Chip-Seq_HEK293_Human	1.94425600
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94018328
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90580253
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85811296
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.72640701
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.67165182
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.63099470
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.60113021
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60113021
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59589425
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57377506
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.57208494
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57102814
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54128150
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50924879
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45994324
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.44059086
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43392590
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42407057
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42325058
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42325058
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.41940318
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40866139
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40235731
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39714373
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37900618
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.35950400
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34916745
47	AR_25329375_ChIP-Seq_VCAP_Human	1.34571679
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34518796
49	STAT3_23295773_ChIP-Seq_U87_Human	1.34429376
50	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.34041025
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33262932
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33141144
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33043954
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31120951
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30237103
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30237103
57	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29906820
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29208250
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.29094627
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29061497
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28980696
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28146042
63	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.28137553
64	TCF4_23295773_ChIP-Seq_U87_Human	1.26657803
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24385440
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23504247
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.23443842
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22438256
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21881567
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21278478
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20667182
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20127012
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19195209
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18818194
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13520771
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13377772
77	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.12641561
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12568938
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12298986
80	AR_20517297_ChIP-Seq_VCAP_Human	1.12209646
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.09723682
82	EZH2_22144423_ChIP-Seq_EOC_Human	1.09400861
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08718386
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08140727
85	NCOR_22424771_ChIP-Seq_293T_Human	1.07384358
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07030141
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06028740
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05677467
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.05140190
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04989943
91	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.04334833
92	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04076940
93	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02332676
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02295288
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01722167
96	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.99399876
97	GATA3_26560356_Chip-Seq_TH2_Human	0.98834260
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98729248
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98510370
100	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97703584

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.28228361
2	MP0008877_abnormal_DNA_methylation	2.97996096
3	MP0002837_dystrophic_cardiac_calcinosis	2.76623905
4	MP0006072_abnormal_retinal_apoptosis	2.56965593
5	MP0000372_irregular_coat_pigmentation	2.52715559
6	MP0001984_abnormal_olfaction	2.43635467
7	MP0005645_abnormal_hypothalamus_physiol	2.38768315
8	MP0005646_abnormal_pituitary_gland	2.37272864
9	MP0001968_abnormal_touch/_nociception	2.23901194
10	MP0005551_abnormal_eye_electrophysiolog	2.17495321
11	MP0005253_abnormal_eye_physiology	2.02896385
12	MP0002876_abnormal_thyroid_physiology	2.00068443
13	MP0001529_abnormal_vocalization	1.99537400
14	MP0003787_abnormal_imprinting	1.97080628
15	MP0003195_calcinosis	1.94791756
16	MP0004147_increased_porphyrin_level	1.89963321
17	MP0002254_reproductive_system_inflammat	1.87341927
18	MP0001501_abnormal_sleep_pattern	1.85725741
19	MP0005360_urolithiasis	1.82336897
20	MP0002822_catalepsy	1.75430910
21	MP0004885_abnormal_endolymph	1.73277698
22	MP0006276_abnormal_autonomic_nervous	1.70720690
23	MP0001986_abnormal_taste_sensitivity	1.70573813
24	MP0005379_endocrine/exocrine_gland_phen	1.68823265
25	MP0008875_abnormal_xenobiotic_pharmacok	1.67989037
26	MP0008872_abnormal_physiological_respon	1.61400828
27	MP0002736_abnormal_nociception_after	1.58807927
28	MP0002234_abnormal_pharynx_morphology	1.57841212
29	MP0001486_abnormal_startle_reflex	1.57773420
30	MP0002272_abnormal_nervous_system	1.55917178
31	MP0000427_abnormal_hair_cycle	1.54273892
32	MP0009745_abnormal_behavioral_response	1.54231321
33	MP0002653_abnormal_ependyma_morphology	1.53057772
34	MP0002638_abnormal_pupillary_reflex	1.45114389
35	MP0004133_heterotaxia	1.43015446
36	MP0000631_abnormal_neuroendocrine_gland	1.42077803
37	MP0005084_abnormal_gallbladder_morpholo	1.41889718
38	MP0003011_delayed_dark_adaptation	1.41166023
39	MP0005389_reproductive_system_phenotype	1.39852174
40	MP0005075_abnormal_melanosome_morpholog	1.39268792
41	MP0003136_yellow_coat_color	1.38997636
42	MP0001919_abnormal_reproductive_system	1.36834140
43	MP0009046_muscle_twitch	1.34911461
44	MP0002909_abnormal_adrenal_gland	1.30637806
45	MP0002733_abnormal_thermal_nociception	1.30058096
46	MP0002557_abnormal_social/conspecific_i	1.29754457
47	MP0004145_abnormal_muscle_electrophysio	1.26868797
48	MP0004043_abnormal_pH_regulation	1.25840894
49	MP0003880_abnormal_central_pattern	1.25051751
50	MP0005671_abnormal_response_to	1.24897006
51	MP0005085_abnormal_gallbladder_physiolo	1.24479729
52	MP0002938_white_spotting	1.23593695
53	MP0006292_abnormal_olfactory_placode	1.22881638
54	MP0004924_abnormal_behavior	1.19680338
55	MP0005386_behavior/neurological_phenoty	1.19680338
56	MP0003121_genomic_imprinting	1.19259952
57	MP0005174_abnormal_tail_pigmentation	1.19110651
58	MP0008789_abnormal_olfactory_epithelium	1.18865903
59	MP0001970_abnormal_pain_threshold	1.17505006
60	MP0004142_abnormal_muscle_tone	1.14523531
61	MP0002572_abnormal_emotion/affect_behav	1.12422411
62	MP0003646_muscle_fatigue	1.11615042
63	MP0003122_maternal_imprinting	1.10000445
64	MP0002160_abnormal_reproductive_system	1.09909377
65	MP0003724_increased_susceptibility_to	1.08744439
66	MP0005410_abnormal_fertilization	1.08655793
67	MP0005332_abnormal_amino_acid	1.07996733
68	MP0002751_abnormal_autonomic_nervous	1.06499889
69	MP0008995_early_reproductive_senescence	1.05305201
70	MP0002163_abnormal_gland_morphology	1.04631271
71	MP0003252_abnormal_bile_duct	1.03896679
72	MP0002735_abnormal_chemical_nociception	1.03749220
73	MP0000569_abnormal_digit_pigmentation	1.03593026
74	MP0001905_abnormal_dopamine_level	1.03154958
75	MP0009780_abnormal_chondrocyte_physiolo	0.98627693
76	MP0010386_abnormal_urinary_bladder	0.98161502
77	MP0002138_abnormal_hepatobiliary_system	0.96662804
78	MP0001764_abnormal_homeostasis	0.95672250
79	MP0002063_abnormal_learning/memory/cond	0.91075686
80	MP0000647_abnormal_sebaceous_gland	0.89722747
81	MP0002277_abnormal_respiratory_mucosa	0.89495496
82	MP0008058_abnormal_DNA_repair	0.88586805
83	MP0001756_abnormal_urination	0.88075176
84	MP0002064_seizures	0.87769384
85	MP0005365_abnormal_bile_salt	0.87594392
86	MP0010329_abnormal_lipoprotein_level	0.87203713
87	MP0000538_abnormal_urinary_bladder	0.86008456
88	MP0001873_stomach_inflammation	0.85710168
89	MP0002067_abnormal_sensory_capabilities	0.83188733
90	MP0005394_taste/olfaction_phenotype	0.82270729
91	MP0005499_abnormal_olfactory_system	0.82270729
92	MP0002229_neurodegeneration	0.81609481
93	MP0002693_abnormal_pancreas_physiology	0.81494944
94	MP0000230_abnormal_systemic_arterial	0.81114973
95	MP0003137_abnormal_impulse_conducting	0.80341955
96	MP0005195_abnormal_posterior_eye	0.80004191
97	MP0002095_abnormal_skin_pigmentation	0.78726709
98	MP0003635_abnormal_synaptic_transmissio	0.78180658
99	MP0001485_abnormal_pinna_reflex	0.75944526
100	MP0005636_abnormal_mineral_homeostasis	0.75205008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.70062078
2	Type II lissencephaly (HP:0007260)	3.67548504
3	Nephronophthisis (HP:0000090)	3.63314889
4	Congenital stationary night blindness (HP:0007642)	3.53782206
5	Renal cortical cysts (HP:0000803)	3.49864757
6	Abnormality of the renal cortex (HP:0011035)	3.44381951
7	Pancreatic fibrosis (HP:0100732)	3.25400659
8	True hermaphroditism (HP:0010459)	3.23001692
9	Medial flaring of the eyebrow (HP:0010747)	3.22995324
10	Abnormality of midbrain morphology (HP:0002418)	3.17427891
11	Molar tooth sign on MRI (HP:0002419)	3.17427891
12	Abnormality of the renal medulla (HP:0100957)	3.14472730
13	Attenuation of retinal blood vessels (HP:0007843)	3.03345312
14	3-Methylglutaconic aciduria (HP:0003535)	2.92839767
15	Hyperventilation (HP:0002883)	2.89548278
16	Cerebellar dysplasia (HP:0007033)	2.88305473
17	Abolished electroretinogram (ERG) (HP:0000550)	2.73355259
18	Lissencephaly (HP:0001339)	2.63089921
19	Severe muscular hypotonia (HP:0006829)	2.58412922
20	Hyperalaninemia (HP:0003348)	2.56680572
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.56680572
22	Abnormality of alanine metabolism (HP:0010916)	2.56680572
23	Methylmalonic acidemia (HP:0002912)	2.52131031
24	Progressive inability to walk (HP:0002505)	2.51552000
25	Inability to walk (HP:0002540)	2.49957599
26	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.49427047
27	Focal motor seizures (HP:0011153)	2.46409873
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.42803166
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.40335121
30	Gait imbalance (HP:0002141)	2.38600861
31	Acute necrotizing encephalopathy (HP:0006965)	2.36432192
32	Congenital primary aphakia (HP:0007707)	2.34383459
33	Increased CSF lactate (HP:0002490)	2.31360664
34	Intestinal atresia (HP:0011100)	2.29869059
35	Chronic hepatic failure (HP:0100626)	2.28656011
36	Gaze-evoked nystagmus (HP:0000640)	2.28589139
37	Constricted visual fields (HP:0001133)	2.27977834
38	Mitochondrial inheritance (HP:0001427)	2.26932936
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25157385
40	Methylmalonic aciduria (HP:0012120)	2.23166583
41	Stomatitis (HP:0010280)	2.22855269
42	Nephrogenic diabetes insipidus (HP:0009806)	2.18741748
43	Decreased central vision (HP:0007663)	2.17609102
44	Optic disc pallor (HP:0000543)	2.16839786
45	Progressive cerebellar ataxia (HP:0002073)	2.15763279
46	Broad-based gait (HP:0002136)	2.15511569
47	Hypothermia (HP:0002045)	2.15458485
48	Hemiparesis (HP:0001269)	2.13133768
49	Progressive macrocephaly (HP:0004481)	2.10250062
50	Tubulointerstitial nephritis (HP:0001970)	2.09982905
51	Acute encephalopathy (HP:0006846)	2.09430195
52	Pachygyria (HP:0001302)	2.08411229
53	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05152214
54	Hepatic necrosis (HP:0002605)	2.02512811
55	Hepatocellular necrosis (HP:0001404)	2.00837817
56	Cystic liver disease (HP:0006706)	2.00757099
57	Tongue fasciculations (HP:0001308)	2.00349441
58	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00209673
59	Abnormal protein N-linked glycosylation (HP:0012347)	2.00209673
60	Abnormal protein glycosylation (HP:0012346)	2.00209673
61	Abnormal glycosylation (HP:0012345)	2.00209673
62	Thyroid-stimulating hormone excess (HP:0002925)	1.99307245
63	Brushfield spots (HP:0001088)	1.97141557
64	Keratoconus (HP:0000563)	1.95639300
65	Increased corneal curvature (HP:0100692)	1.95639300
66	Chronic bronchitis (HP:0004469)	1.95589363
67	Hyperglycinemia (HP:0002154)	1.94782467
68	Abnormal drinking behavior (HP:0030082)	1.94736428
69	Polydipsia (HP:0001959)	1.94736428
70	Tubular atrophy (HP:0000092)	1.92543246
71	Abnormality of the labia minora (HP:0012880)	1.92440543
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.91800669
73	Abnormality of vitamin B metabolism (HP:0004340)	1.91260918
74	Stomach cancer (HP:0012126)	1.91169996
75	Pendular nystagmus (HP:0012043)	1.89057573
76	Increased serum lactate (HP:0002151)	1.85143355
77	Furrowed tongue (HP:0000221)	1.84028099
78	Abnormal biliary tract physiology (HP:0012439)	1.81764637
79	Bile duct proliferation (HP:0001408)	1.81764637
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79984201
81	Genital tract atresia (HP:0001827)	1.79080721
82	Retinal dysplasia (HP:0007973)	1.77321756
83	Large for gestational age (HP:0001520)	1.77138565
84	Vaginal atresia (HP:0000148)	1.77110050
85	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75915222
86	Absent/shortened dynein arms (HP:0200106)	1.75915222
87	Thyroiditis (HP:0100646)	1.75327166
88	Progressive microcephaly (HP:0000253)	1.75170749
89	Agitation (HP:0000713)	1.74096974
90	Postaxial foot polydactyly (HP:0001830)	1.73442972
91	Hypoplasia of the uterus (HP:0000013)	1.72052471
92	Lipid accumulation in hepatocytes (HP:0006561)	1.71946565
93	Hyperglycinuria (HP:0003108)	1.70167356
94	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69077939
95	Congenital hepatic fibrosis (HP:0002612)	1.68002512
96	Lactic acidosis (HP:0003128)	1.67601364
97	Type I transferrin isoform profile (HP:0003642)	1.67010286
98	Hypoproteinemia (HP:0003075)	1.65969162
99	Abnormality of glycine metabolism (HP:0010895)	1.65948266
100	Abnormality of serine family amino acid metabolism (HP:0010894)	1.65948266

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.50526073
2	WNK3	3.99897927
3	TAOK3	3.19126316
4	FRK	3.16542234
5	BCKDK	2.70102265
6	BMPR1B	2.64285603
7	PINK1	2.55941159
8	ZAK	2.55779803
9	ADRBK2	2.31575087
10	GRK1	2.22372024
11	NUAK1	2.21066488
12	TRIM28	2.18020383
13	MST4	2.14106857
14	CASK	2.07118859
15	TXK	1.90634110
16	OXSR1	1.78648679
17	INSRR	1.62315152
18	WNK4	1.58039690
19	BCR	1.57829315
20	MAP3K4	1.52845771
21	PAK3	1.50793058
22	ACVR1B	1.41020785
23	TLK1	1.40909224
24	CAMKK2	1.38224897
25	MAPK13	1.32518370
26	TRPM7	1.26154438
27	STK39	1.22465112
28	MAP2K6	1.18958749
29	CSNK1G1	1.07762916
30	MAPKAPK3	1.06279154
31	PLK2	1.03504417
32	PRKCE	1.01212747
33	ERBB3	1.00617962
34	SIK3	1.00238747
35	PHKG1	0.98946714
36	PHKG2	0.98946714
37	CSNK1G3	0.97200489
38	FLT3	0.95450746
39	TGFBR1	0.91257352
40	MARK1	0.90688732
41	MAP2K2	0.88696536
42	CSNK1G2	0.84395650
43	MKNK1	0.81805704
44	IKBKB	0.80893463
45	GRK6	0.79282600
46	DAPK2	0.78741068
47	EPHA3	0.78588909
48	NEK1	0.78068549
49	DYRK2	0.77683284
50	TNK2	0.76946529
51	CSNK1A1L	0.76197084
52	MKNK2	0.73884705
53	GRK5	0.72896582
54	PRKCG	0.72632782
55	VRK1	0.72487871
56	FER	0.71035418
57	STK38L	0.69516958
58	BRSK2	0.68612397
59	ADRBK1	0.65813864
60	MUSK	0.65783029
61	MAPKAPK5	0.65566867
62	IRAK1	0.65562270
63	DAPK1	0.63333442
64	LIMK1	0.58909254
65	PRKCQ	0.57510919
66	TNIK	0.56936988
67	EIF2AK3	0.55126521
68	TSSK6	0.53726535
69	PDK2	0.53071478
70	PLK3	0.52908710
71	TIE1	0.51561514
72	MAP2K7	0.51060295
73	ITK	0.48120891
74	PAK6	0.47540762
75	RPS6KA4	0.47103912
76	KIT	0.46306152
77	PTK2B	0.45036389
78	TEC	0.44716285
79	PNCK	0.44337664
80	CAMK2A	0.42771189
81	IGF1R	0.42367312
82	PRKCI	0.42353452
83	CDK8	0.41448379
84	RPS6KA5	0.41305162
85	MATK	0.40727079
86	CSNK1A1	0.40204910
87	DYRK3	0.40171040
88	NLK	0.38978020
89	FGFR2	0.38150451
90	CAMK2D	0.38079314
91	DYRK1A	0.36977660
92	PRKACA	0.34910979
93	MAP2K1	0.32023538
94	PRKCA	0.31050000
95	EPHA4	0.30470798
96	MAP3K14	0.29154639
97	SRPK1	0.28306928
98	CSNK1D	0.27773287
99	CHUK	0.27210044
100	NEK6	0.26135424

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.04786567
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.95789012
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.80424872
4	Protein export_Homo sapiens_hsa03060	2.76025296
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.48814192
6	RNA polymerase_Homo sapiens_hsa03020	2.47977818
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.27515998
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.22116525
9	Butanoate metabolism_Homo sapiens_hsa00650	2.17441308
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.01379674
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99063292
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96777987
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.80809952
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.76296137
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.75463172
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.70933297
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70505913
18	Propanoate metabolism_Homo sapiens_hsa00640	1.69443617
19	Parkinsons disease_Homo sapiens_hsa05012	1.69332122
20	Peroxisome_Homo sapiens_hsa04146	1.65044638
21	Nicotine addiction_Homo sapiens_hsa05033	1.62051348
22	One carbon pool by folate_Homo sapiens_hsa00670	1.61424439
23	Taste transduction_Homo sapiens_hsa04742	1.60269867
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59977152
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56043750
26	RNA degradation_Homo sapiens_hsa03018	1.52415875
27	Proteasome_Homo sapiens_hsa03050	1.50567119
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46852658
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.43638972
30	Basal transcription factors_Homo sapiens_hsa03022	1.40633901
31	Caffeine metabolism_Homo sapiens_hsa00232	1.36924876
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.33135867
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.28877950
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26903567
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.15254867
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.14483741
37	Homologous recombination_Homo sapiens_hsa03440	1.12586017
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12167654
39	Regulation of autophagy_Homo sapiens_hsa04140	1.10258670
40	Fatty acid elongation_Homo sapiens_hsa00062	1.09858393
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08393504
42	Sulfur metabolism_Homo sapiens_hsa00920	1.07681355
43	Morphine addiction_Homo sapiens_hsa05032	0.99476861
44	Type I diabetes mellitus_Homo sapiens_hsa04940	0.98434316
45	ABC transporters_Homo sapiens_hsa02010	0.98374950
46	Olfactory transduction_Homo sapiens_hsa04740	0.98206191
47	Alzheimers disease_Homo sapiens_hsa05010	0.96400307
48	Huntingtons disease_Homo sapiens_hsa05016	0.95284356
49	Retinol metabolism_Homo sapiens_hsa00830	0.92601126
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.92221952
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89990814
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89354807
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87350087
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.87242625
55	Serotonergic synapse_Homo sapiens_hsa04726	0.86461911
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.84649925
57	Purine metabolism_Homo sapiens_hsa00230	0.84188132
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83881420
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83403326
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82592750
61	Insulin secretion_Homo sapiens_hsa04911	0.81712837
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81610563
63	Circadian rhythm_Homo sapiens_hsa04710	0.79166806
64	GABAergic synapse_Homo sapiens_hsa04727	0.77427384
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.75863526
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73565733
67	Metabolic pathways_Homo sapiens_hsa01100	0.72530962
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70951677
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70295161
70	Folate biosynthesis_Homo sapiens_hsa00790	0.68261576
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68059740
72	Circadian entrainment_Homo sapiens_hsa04713	0.67389908
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66540800
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66010076
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65313285
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65237642
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.62373874
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62095255
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61803455
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61701422
81	Salivary secretion_Homo sapiens_hsa04970	0.59575593
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53166558
83	Mineral absorption_Homo sapiens_hsa04978	0.52588397
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51559518
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.51132617
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.49714038
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49673540
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49458217
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49318174
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.49215382
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46934645
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.46290671
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45390252
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.43728154
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.41477817
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40729154
97	Allograft rejection_Homo sapiens_hsa05330	0.39868280
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.39748162
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.39475317
100	Asthma_Homo sapiens_hsa05310	0.39290152

HMGN1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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