ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.07548849
2	cell proliferation in forebrain (GO:0021846)	5.92970991
3	sulfation (GO:0051923)	5.31032103
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.95896321
5	regulation of glomerulus development (GO:0090192)	4.86963136
6	cellular response to ATP (GO:0071318)	4.65105352
7	otic vesicle formation (GO:0030916)	4.62150780
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.46967584
9	NADH dehydrogenase complex assembly (GO:0010257)	4.46967584
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.46967584
11	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.44282591
12	positive regulation of fatty acid oxidation (GO:0046321)	4.22075734
13	regulation of cell proliferation involved in kidney development (GO:1901722)	4.17467827
14	pharyngeal system development (GO:0060037)	4.16213912
15	positive regulation of cAMP-mediated signaling (GO:0043950)	4.00673719
16	DNA deamination (GO:0045006)	3.88827616
17	protein complex biogenesis (GO:0070271)	3.85959745
18	negative regulation of systemic arterial blood pressure (GO:0003085)	3.84812589
19	protein polyglutamylation (GO:0018095)	3.79271944
20	negative regulation of cardiac muscle tissue development (GO:0055026)	3.65276112
21	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.63453517
22	regulation of sequestering of triglyceride (GO:0010889)	3.57377961
23	somite development (GO:0061053)	3.55047727
24	negative regulation of response to food (GO:0032096)	3.52922810
25	negative regulation of appetite (GO:0032099)	3.52922810
26	lung morphogenesis (GO:0060425)	3.49808683
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.49043098
28	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.48491754
29	gamma-aminobutyric acid transport (GO:0015812)	3.42457630
30	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.36278026
31	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.36278026
32	chaperone-mediated protein transport (GO:0072321)	3.35109998
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.29834232
34	regulation of collateral sprouting (GO:0048670)	3.24383644
35	mesonephros development (GO:0001823)	3.23929485
36	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.22619788
37	regulation of DNA endoreduplication (GO:0032875)	3.18471874
38	kynurenine metabolic process (GO:0070189)	3.17465957
39	regulation of gene silencing by RNA (GO:0060966)	3.14709240
40	regulation of posttranscriptional gene silencing (GO:0060147)	3.14709240
41	regulation of gene silencing by miRNA (GO:0060964)	3.14709240
42	negative regulation of telomere maintenance (GO:0032205)	3.11542474
43	forebrain morphogenesis (GO:0048853)	3.11360780
44	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.09654368
45	indole-containing compound catabolic process (GO:0042436)	3.09228427
46	indolalkylamine catabolic process (GO:0046218)	3.09228427
47	tryptophan catabolic process (GO:0006569)	3.09228427
48	positive regulation of metanephros development (GO:0072216)	3.08048844
49	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.06897555
50	indolalkylamine metabolic process (GO:0006586)	3.05803292
51	regulation of female receptivity (GO:0045924)	3.02667592
52	cellular anion homeostasis (GO:0030002)	3.02358494
53	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.98610854
54	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.98200589
55	ATP synthesis coupled proton transport (GO:0015986)	2.98200589
56	pituitary gland development (GO:0021983)	2.96760568
57	embryonic hindlimb morphogenesis (GO:0035116)	2.94889929
58	serotonin metabolic process (GO:0042428)	2.93323397
59	negative regulation of mast cell activation (GO:0033004)	2.93194816
60	regulation of phospholipid biosynthetic process (GO:0071071)	2.93190219
61	parturition (GO:0007567)	2.92533818
62	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.89121825
63	response to UV-C (GO:0010225)	2.86885647
64	dentate gyrus development (GO:0021542)	2.86262889
65	positive regulation of digestive system process (GO:0060456)	2.85466333
66	transmission of nerve impulse (GO:0019226)	2.83544216
67	positive regulation of glomerulus development (GO:0090193)	2.82961014
68	primary amino compound metabolic process (GO:1901160)	2.82208312
69	negative regulation of telomerase activity (GO:0051974)	2.81989393
70	tryptophan metabolic process (GO:0006568)	2.81313308
71	indole-containing compound metabolic process (GO:0042430)	2.74598717
72	neurofilament cytoskeleton organization (GO:0060052)	2.73713344
73	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72861364
74	regulation of mesoderm development (GO:2000380)	2.69899295
75	lymphangiogenesis (GO:0001946)	2.69698545
76	organ induction (GO:0001759)	2.69163859
77	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.68846492
78	flavonoid metabolic process (GO:0009812)	2.66210801
79	outer ear morphogenesis (GO:0042473)	2.65087150
80	tooth mineralization (GO:0034505)	2.64899799
81	endoderm formation (GO:0001706)	2.64284492
82	peristalsis (GO:0030432)	2.63983102
83	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.63954841
84	branching involved in labyrinthine layer morphogenesis (GO:0060670)	2.63907975
85	white fat cell differentiation (GO:0050872)	2.63702850
86	negative regulation of multicellular organism growth (GO:0040015)	2.63232602
87	dorsal/ventral axis specification (GO:0009950)	2.61429240
88	negative regulation of gene silencing (GO:0060969)	2.60990083
89	lateral sprouting from an epithelium (GO:0060601)	2.59970290
90	adaptation of signaling pathway (GO:0023058)	2.59551425
91	cell migration involved in gastrulation (GO:0042074)	2.58003136
92	forebrain neuron development (GO:0021884)	2.57783146
93	mitochondrion morphogenesis (GO:0070584)	2.56289936
94	signal transduction involved in regulation of gene expression (GO:0023019)	2.55764926
95	GPI anchor metabolic process (GO:0006505)	2.55744556
96	N-acetylglucosamine metabolic process (GO:0006044)	2.54596014
97	female mating behavior (GO:0060180)	2.53683970
98	positive regulation of fatty acid transport (GO:2000193)	2.53204886
99	metanephros development (GO:0001656)	2.52056521
100	negative regulation of astrocyte differentiation (GO:0048712)	2.50753686

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.71852628
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.24528075
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.62908741
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.95126066
5	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.74171652
6	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.72124948
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54550236
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.48705926
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.38101694
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30223972
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.27304288
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.26300384
13	VDR_22108803_ChIP-Seq_LS180_Human	2.13063094
14	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.10153047
15	FUS_26573619_Chip-Seq_HEK293_Human	2.02552567
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99719556
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92921054
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.90270155
19	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.89393017
20	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.89260571
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89006739
22	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.85942007
23	EWS_26573619_Chip-Seq_HEK293_Human	1.78980864
24	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.72617323
25	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.71174394
26	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.71174394
27	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.66449598
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.65935920
29	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.65907600
30	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.64641541
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.63178690
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60474961
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.59565148
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.59080161
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.58385930
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58278769
37	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.55595209
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53862785
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.53514250
40	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.53504135
41	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.52031660
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51974887
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51862466
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51031654
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.49200995
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.49134647
47	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48342907
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.41805090
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38606618
50	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.36003871
51	P300_19829295_ChIP-Seq_ESCs_Human	1.33474973
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.32247418
53	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.27245745
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21631909
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.18398414
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18398414
57	NCOR_22424771_ChIP-Seq_293T_Human	1.16622781
58	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.16192296
59	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.15009629
60	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.14798913
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14005558
62	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.13132171
63	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.12538413
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.10990028
65	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.10372556
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08383444
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04494152
68	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02748226
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02709131
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01419634
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.01369374
72	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00955735
73	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.99066818
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98223330
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97314263
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97314263
77	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.96869681
78	AR_25329375_ChIP-Seq_VCAP_Human	0.96797507
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96574569
80	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96124726
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95000578
82	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94691211
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94094551
84	TCF4_23295773_ChIP-Seq_U87_Human	0.93722026
85	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93585375
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.91591420
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88143430
88	KDM2B_26808549_Chip-Seq_REH_Human	0.87845360
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86299197
90	STAT3_23295773_ChIP-Seq_U87_Human	0.86233506
91	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.85739295
92	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85395799
93	JUN_21703547_ChIP-Seq_K562_Human	0.84990911
94	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.84663097
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83989830
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.83596466
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.81145331
98	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.80594934
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.78618380
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.78618380

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.52170466
2	MP0002138_abnormal_hepatobiliary_system	3.45827712
3	MP0005646_abnormal_pituitary_gland	3.29160742
4	MP0002160_abnormal_reproductive_system	2.92744118
5	MP0000049_abnormal_middle_ear	2.87472871
6	MP0005670_abnormal_white_adipose	2.52657797
7	MP0001485_abnormal_pinna_reflex	2.50698165
8	MP0004885_abnormal_endolymph	2.38210544
9	MP0004134_abnormal_chest_morphology	2.25374165
10	MP0000631_abnormal_neuroendocrine_gland	2.17362682
11	MP0000678_abnormal_parathyroid_gland	2.15738417
12	MP0004145_abnormal_muscle_electrophysio	2.11177793
13	MP0005389_reproductive_system_phenotype	2.10555278
14	MP0002876_abnormal_thyroid_physiology	2.04889073
15	MP0002837_dystrophic_cardiac_calcinosis	2.04502886
16	MP0009379_abnormal_foot_pigmentation	1.94338221
17	MP0002163_abnormal_gland_morphology	1.85406996
18	MP0003646_muscle_fatigue	1.81018318
19	MP0008872_abnormal_physiological_respon	1.75943611
20	MP0004130_abnormal_muscle_cell	1.72603413
21	MP0005551_abnormal_eye_electrophysiolog	1.71902040
22	MP0004142_abnormal_muscle_tone	1.66932978
23	MP0002102_abnormal_ear_morphology	1.65110653
24	MP0001968_abnormal_touch/_nociception	1.64447722
25	MP0003938_abnormal_ear_development	1.64392807
26	MP0008877_abnormal_DNA_methylation	1.64056292
27	MP0009250_abnormal_appendicular_skeleto	1.63282926
28	MP0002653_abnormal_ependyma_morphology	1.63222212
29	MP0003195_calcinosis	1.59671609
30	MP0002272_abnormal_nervous_system	1.57920522
31	MP0009053_abnormal_anal_canal	1.57698294
32	MP0004133_heterotaxia	1.50097429
33	MP0003942_abnormal_urinary_system	1.46424350
34	MP0003787_abnormal_imprinting	1.41263185
35	MP0001440_abnormal_grooming_behavior	1.40673689
36	MP0005084_abnormal_gallbladder_morpholo	1.39704262
37	MP0009745_abnormal_behavioral_response	1.38536301
38	MP0003937_abnormal_limbs/digits/tail_de	1.35659818
39	MP0006072_abnormal_retinal_apoptosis	1.34109643
40	MP0003119_abnormal_digestive_system	1.29123237
41	MP0002249_abnormal_larynx_morphology	1.23901288
42	MP0005379_endocrine/exocrine_gland_phen	1.19947010
43	MP0003879_abnormal_hair_cell	1.19100813
44	MP0002734_abnormal_mechanical_nocicepti	1.18861583
45	MP0000026_abnormal_inner_ear	1.18525312
46	MP0001986_abnormal_taste_sensitivity	1.18269418
47	MP0001963_abnormal_hearing_physiology	1.13812004
48	MP0002733_abnormal_thermal_nociception	1.11953045
49	MP0009384_cardiac_valve_regurgitation	1.11938256
50	MP0003638_abnormal_response/metabolism_	1.10479683
51	MP0002139_abnormal_hepatobiliary_system	1.10146646
52	MP0001188_hyperpigmentation	1.10103769
53	MP0002277_abnormal_respiratory_mucosa	1.09502987
54	MP0002736_abnormal_nociception_after	1.09321870
55	MP0003724_increased_susceptibility_to	1.08607435
56	MP0005083_abnormal_biliary_tract	1.08063514
57	MP0001919_abnormal_reproductive_system	1.07944350
58	MP0006276_abnormal_autonomic_nervous	1.06035710
59	MP0001486_abnormal_startle_reflex	1.05652633
60	MP0000613_abnormal_salivary_gland	1.05504882
61	MP0002735_abnormal_chemical_nociception	1.04258427
62	MP0003567_abnormal_fetal_cardiomyocyte	1.04055137
63	MP0002064_seizures	1.02082371
64	MP0005195_abnormal_posterior_eye	1.01375308
65	MP0003880_abnormal_central_pattern	1.01195163
66	MP0003283_abnormal_digestive_organ	0.99882806
67	MP0001542_abnormal_bone_strength	0.98301072
68	MP0009046_muscle_twitch	0.97929012
69	MP0001970_abnormal_pain_threshold	0.96515061
70	MP0002928_abnormal_bile_duct	0.95366079
71	MP0008995_early_reproductive_senescence	0.94420380
72	MP0003936_abnormal_reproductive_system	0.92469546
73	MP0002752_abnormal_somatic_nervous	0.92255530
74	MP0008789_abnormal_olfactory_epithelium	0.92077041
75	MP0000013_abnormal_adipose_tissue	0.91651777
76	MP0005360_urolithiasis	0.91144495
77	MP0003635_abnormal_synaptic_transmissio	0.90294024
78	MP0002638_abnormal_pupillary_reflex	0.90038946
79	MP0002282_abnormal_trachea_morphology	0.89796759
80	MP0002184_abnormal_innervation	0.89032163
81	MP0002557_abnormal_social/conspecific_i	0.88927770
82	MP0003011_delayed_dark_adaptation	0.88048273
83	MP0001293_anophthalmia	0.87759846
84	MP0001905_abnormal_dopamine_level	0.85929846
85	MP0004742_abnormal_vestibular_system	0.85512363
86	MP0000372_irregular_coat_pigmentation	0.84194349
87	MP0000537_abnormal_urethra_morphology	0.83992698
88	MP0002063_abnormal_learning/memory/cond	0.81751999
89	MP0009780_abnormal_chondrocyte_physiolo	0.79854200
90	MP0005423_abnormal_somatic_nervous	0.79024241
91	MP0002938_white_spotting	0.78526829
92	MP0002572_abnormal_emotion/affect_behav	0.76809016
93	MP0000230_abnormal_systemic_arterial	0.76305500
94	MP0004185_abnormal_adipocyte_glucose	0.74387950
95	MP0000516_abnormal_urinary_system	0.74300885
96	MP0005367_renal/urinary_system_phenotyp	0.74300885
97	MP0005253_abnormal_eye_physiology	0.72980268
98	MP0003315_abnormal_perineum_morphology	0.72598807
99	MP0003123_paternal_imprinting	0.71903775
100	MP0002116_abnormal_craniofacial_bone	0.70056924

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	4.79545211
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.10093517
3	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.60209792
4	Short 1st metacarpal (HP:0010034)	3.60209792
5	Pancreatic fibrosis (HP:0100732)	3.49674737
6	True hermaphroditism (HP:0010459)	3.41526472
7	Pancreatic cysts (HP:0001737)	3.41128651
8	Abolished electroretinogram (ERG) (HP:0000550)	3.38882605
9	Genetic anticipation (HP:0003743)	3.32148797
10	Abnormality of the renal collecting system (HP:0004742)	3.27802560
11	Severe visual impairment (HP:0001141)	3.25806461
12	Methylmalonic acidemia (HP:0002912)	3.19389252
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.17737358
14	Increased corneal curvature (HP:0100692)	3.15942560
15	Keratoconus (HP:0000563)	3.15942560
16	Abnormality of the 1st metacarpal (HP:0010009)	3.14602834
17	Stenosis of the external auditory canal (HP:0000402)	3.11142841
18	Absent thumb (HP:0009777)	3.08938331
19	Abnormality of DNA repair (HP:0003254)	3.01433498
20	Ectopic kidney (HP:0000086)	2.90415712
21	Agitation (HP:0000713)	2.85192756
22	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.84216610
23	Progressive cerebellar ataxia (HP:0002073)	2.82909752
24	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.78547634
25	Porencephaly (HP:0002132)	2.76884531
26	Asplenia (HP:0001746)	2.73981218
27	Methylmalonic aciduria (HP:0012120)	2.72729457
28	Morphological abnormality of the middle ear (HP:0008609)	2.71413489
29	Abnormality of the nasal septum (HP:0000419)	2.69254683
30	Septo-optic dysplasia (HP:0100842)	2.68854372
31	Acute necrotizing encephalopathy (HP:0006965)	2.67245950
32	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.66432202
33	Short phalanx of the thumb (HP:0009660)	2.66135455
34	Decreased central vision (HP:0007663)	2.65699281
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.61015851
36	Confusion (HP:0001289)	2.60942641
37	Abnormality of the middle phalanges of the toes (HP:0010183)	2.57901014
38	Short hallux (HP:0010109)	2.56734623
39	3-Methylglutaconic aciduria (HP:0003535)	2.54194384
40	Molar tooth sign on MRI (HP:0002419)	2.53314924
41	Abnormality of midbrain morphology (HP:0002418)	2.53314924
42	Congenital stationary night blindness (HP:0007642)	2.51615628
43	Congenital sensorineural hearing impairment (HP:0008527)	2.47839232
44	Reticulocytopenia (HP:0001896)	2.44870355
45	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.43432765
46	Nephronophthisis (HP:0000090)	2.42492067
47	Carpal bone hypoplasia (HP:0001498)	2.40327687
48	Abnormal mitochondria in muscle tissue (HP:0008316)	2.36454634
49	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.32978701
50	Mitochondrial inheritance (HP:0001427)	2.28992463
51	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.26464726
52	Congenital, generalized hypertrichosis (HP:0004540)	2.25220046
53	Progressive macrocephaly (HP:0004481)	2.24734282
54	Synostosis of carpal bones (HP:0005048)	2.24621483
55	Duplicated collecting system (HP:0000081)	2.21534219
56	Acute encephalopathy (HP:0006846)	2.20129378
57	Chorioretinal atrophy (HP:0000533)	2.18778269
58	Humeroradial synostosis (HP:0003041)	2.17412862
59	Synostosis involving the elbow (HP:0003938)	2.17412862
60	Hypoplasia of the uterus (HP:0000013)	2.15273830
61	Anomalous pulmonary venous return (HP:0010772)	2.12695567
62	Cystic liver disease (HP:0006706)	2.11083164
63	Sclerocornea (HP:0000647)	2.10913543
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.10533425
65	Visual hallucinations (HP:0002367)	2.09348032
66	Abnormality of cochlea (HP:0000375)	2.06962058
67	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05445272
68	Furrowed tongue (HP:0000221)	2.04878539
69	Abnormal number of erythroid precursors (HP:0012131)	2.04872111
70	Decreased subcutaneous fat (HP:0001002)	2.00048522
71	Small hand (HP:0200055)	2.00010690
72	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98731156
73	Maternal diabetes (HP:0009800)	1.97395472
74	Male pseudohermaphroditism (HP:0000037)	1.97143736
75	Anencephaly (HP:0002323)	1.96319033
76	Meckel diverticulum (HP:0002245)	1.95794268
77	Horseshoe kidney (HP:0000085)	1.95736576
78	Abnormality of homocysteine metabolism (HP:0010919)	1.95143799
79	Homocystinuria (HP:0002156)	1.95143799
80	Thyroid-stimulating hormone excess (HP:0002925)	1.94944791
81	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94506385
82	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.92944969
83	Increased CSF lactate (HP:0002490)	1.92248662
84	Abnormality of the ileum (HP:0001549)	1.91714033
85	Abnormality of the pulmonary veins (HP:0011718)	1.90772897
86	Abnormality of the renal cortex (HP:0011035)	1.90719442
87	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.90078306
88	Abnormality of alanine metabolism (HP:0010916)	1.87884833
89	Hyperalaninemia (HP:0003348)	1.87884833
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87884833
91	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.86136919
92	Concave nail (HP:0001598)	1.85465610
93	Abnormality of the renal medulla (HP:0100957)	1.85383620
94	Short femoral neck (HP:0100864)	1.84500065
95	Abnormality of the carotid arteries (HP:0005344)	1.84499322
96	Short thumb (HP:0009778)	1.84405014
97	Fused cervical vertebrae (HP:0002949)	1.83959615
98	Goiter (HP:0000853)	1.83175790
99	Hyperglycinemia (HP:0002154)	1.81852667
100	Abnormality of chromosome stability (HP:0003220)	1.80492437

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	4.59949061
2	STK16	4.08418367
3	ADRBK2	4.01861565
4	TAOK3	3.27800394
5	FRK	2.88195164
6	TLK1	2.82178311
7	PINK1	2.38986006
8	TXK	2.35804144
9	PRKD2	2.07824091
10	MAP4K2	2.03178451
11	ZAK	1.82912645
12	NUAK1	1.80846831
13	WNK3	1.75362890
14	DYRK2	1.64971833
15	WNK4	1.64294042
16	BMPR1B	1.62437580
17	CDC7	1.53907595
18	ACVR1B	1.52904729
19	TNIK	1.50430678
20	MAPK13	1.36097124
21	BCKDK	1.34607668
22	PRKCG	1.25906966
23	STK39	1.25294701
24	PLK2	1.24524354
25	VRK2	1.19773693
26	MAP2K7	1.16825929
27	VRK1	1.16059214
28	MAP3K9	1.07208066
29	CASK	1.07145806
30	MAP3K4	1.03558725
31	INSRR	1.01359862
32	TAF1	1.01190191
33	MUSK	1.00170794
34	OXSR1	0.98270819
35	PRKCE	0.97753110
36	CDK9	0.97601139
37	NTRK2	0.97410730
38	CSNK1G1	0.85802994
39	PRKCI	0.85143188
40	AURKA	0.84820899
41	PAK3	0.82663229
42	PLK4	0.82392972
43	NME1	0.81598415
44	IKBKB	0.81508386
45	ADRBK1	0.79800048
46	ABL2	0.79470555
47	CSNK1A1	0.78824915
48	MAP2K2	0.76355273
49	FLT3	0.75280973
50	PRKCQ	0.74719790
51	PDK2	0.73636895
52	MAP4K1	0.73291459
53	RPS6KA5	0.73236637
54	CSNK1G2	0.73179354
55	DYRK3	0.70749169
56	PIK3CA	0.70201718
57	CSNK1G3	0.69637270
58	PRKACA	0.69549097
59	TIE1	0.68340185
60	GRK6	0.68001900
61	GRK5	0.67487815
62	ERBB2	0.66682558
63	GRK7	0.65793520
64	SGK1	0.63144431
65	CAMK1	0.62425048
66	PRKCH	0.61795247
67	DAPK2	0.61734371
68	MAP2K1	0.61424897
69	RPS6KA6	0.60754461
70	SGK2	0.58333004
71	SGK223	0.58177503
72	SGK494	0.58177503
73	MAPKAPK5	0.53719008
74	CDK8	0.53229003
75	TEC	0.52574290
76	CAMK2A	0.49752255
77	MAP2K4	0.49503678
78	MARK1	0.49385004
79	ITK	0.48531159
80	PRKCA	0.48411455
81	ATR	0.47469083
82	PIM1	0.46501593
83	STK3	0.46007399
84	PKN1	0.45964891
85	PRKCZ	0.45562630
86	CSNK2A1	0.45236351
87	PHKG1	0.43961328
88	PHKG2	0.43961328
89	PLK1	0.42994426
90	BLK	0.42766678
91	RPS6KB1	0.42380706
92	CSNK1A1L	0.39440270
93	STK11	0.38837958
94	MAPK15	0.38089033
95	MST4	0.36839166
96	SYK	0.35650211
97	DAPK3	0.34896728
98	MKNK2	0.34504097
99	EPHA4	0.34439380
100	CSNK1D	0.32827592

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.11273041
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.06719647
3	Ribosome_Homo sapiens_hsa03010	2.86101904
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.49311767
5	Parkinsons disease_Homo sapiens_hsa05012	2.46870194
6	Nicotine addiction_Homo sapiens_hsa05033	2.43128628
7	Sulfur metabolism_Homo sapiens_hsa00920	2.31035314
8	Homologous recombination_Homo sapiens_hsa03440	2.25807425
9	Phototransduction_Homo sapiens_hsa04744	2.14738795
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.00953267
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95161094
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.82684552
13	Alzheimers disease_Homo sapiens_hsa05010	1.79429448
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74064133
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.74061527
16	RNA polymerase_Homo sapiens_hsa03020	1.68783994
17	Huntingtons disease_Homo sapiens_hsa05016	1.67062074
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.66011419
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.65322782
20	Morphine addiction_Homo sapiens_hsa05032	1.63231232
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.56481037
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.53020682
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51953193
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48360772
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39344705
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.38376493
27	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.33993207
28	RNA degradation_Homo sapiens_hsa03018	1.31482947
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.28703345
30	Basal transcription factors_Homo sapiens_hsa03022	1.28434761
31	Retinol metabolism_Homo sapiens_hsa00830	1.27912461
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24031749
33	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.21350282
34	One carbon pool by folate_Homo sapiens_hsa00670	1.20182270
35	Taste transduction_Homo sapiens_hsa04742	1.19723640
36	Melanoma_Homo sapiens_hsa05218	1.18727933
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.16741713
38	Basal cell carcinoma_Homo sapiens_hsa05217	1.14298550
39	Olfactory transduction_Homo sapiens_hsa04740	1.12507073
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.09492871
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.09272703
42	Sulfur relay system_Homo sapiens_hsa04122	1.08535867
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07584246
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.06972377
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06497155
46	Glutamatergic synapse_Homo sapiens_hsa04724	1.06396076
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.03433529
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.02081629
49	Protein export_Homo sapiens_hsa03060	1.01102227
50	Insulin secretion_Homo sapiens_hsa04911	1.00412629
51	GABAergic synapse_Homo sapiens_hsa04727	0.99422652
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.96804220
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93264937
54	DNA replication_Homo sapiens_hsa03030	0.92589770
55	Caffeine metabolism_Homo sapiens_hsa00232	0.92474693
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91842309
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.88422920
58	Serotonergic synapse_Homo sapiens_hsa04726	0.87410602
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83290363
60	Circadian entrainment_Homo sapiens_hsa04713	0.82185870
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.80937978
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.80107810
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.73879271
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71548608
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66575987
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64649565
67	Renin secretion_Homo sapiens_hsa04924	0.64606621
68	Alcoholism_Homo sapiens_hsa05034	0.62970598
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62659084
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62264903
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.61281969
72	Butanoate metabolism_Homo sapiens_hsa00650	0.60509182
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59398848
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58860796
75	Purine metabolism_Homo sapiens_hsa00230	0.58103804
76	Peroxisome_Homo sapiens_hsa04146	0.57923727
77	Cholinergic synapse_Homo sapiens_hsa04725	0.55760320
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54866030
79	Renin-angiotensin system_Homo sapiens_hsa04614	0.54227351
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53300113
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53240861
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52346226
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.52136882
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.51429188
85	Asthma_Homo sapiens_hsa05310	0.51081784
86	Metabolic pathways_Homo sapiens_hsa01100	0.49975845
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49835624
88	Cocaine addiction_Homo sapiens_hsa05030	0.48433421
89	Folate biosynthesis_Homo sapiens_hsa00790	0.47583502
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46094756
91	Regulation of autophagy_Homo sapiens_hsa04140	0.45186901
92	Salivary secretion_Homo sapiens_hsa04970	0.45113422
93	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.44206913
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.43955419
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43423322
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43407880
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.40771031
98	Axon guidance_Homo sapiens_hsa04360	0.38935516
99	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36855844
100	Mismatch repair_Homo sapiens_hsa03430	0.34055490

HMGN1P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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