HMGN1P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)6.37125134
2negative regulation of response to food (GO:0032096)5.43441485
3negative regulation of appetite (GO:0032099)5.43441485
4negative regulation of cytosolic calcium ion concentration (GO:0051481)5.40164131
5cell wall macromolecule metabolic process (GO:0044036)5.25159129
6presynaptic membrane organization (GO:0097090)4.84725294
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.77300455
8gamma-aminobutyric acid transport (GO:0015812)4.74358794
9regulation of response to food (GO:0032095)4.43434993
10auditory behavior (GO:0031223)4.41327897
11mechanosensory behavior (GO:0007638)4.15739399
12atrial cardiac muscle cell action potential (GO:0086014)4.10244495
13nonmotile primary cilium assembly (GO:0035058)4.02825280
14striatum development (GO:0021756)3.90332267
15behavioral response to cocaine (GO:0048148)3.90121138
16maturation of SSU-rRNA (GO:0030490)3.76594593
17presynaptic membrane assembly (GO:0097105)3.73654600
18glutamate receptor signaling pathway (GO:0007215)3.72817485
19postsynaptic membrane organization (GO:0001941)3.68891589
20neuron cell-cell adhesion (GO:0007158)3.64230294
21regulation of appetite (GO:0032098)3.61417792
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.52495948
23positive regulation of vesicle fusion (GO:0031340)3.51143071
24response to histamine (GO:0034776)3.47881319
25vocalization behavior (GO:0071625)3.46012100
26neuron-neuron synaptic transmission (GO:0007270)3.44906001
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42372995
28histone H3-K4 trimethylation (GO:0080182)3.35200681
29axon ensheathment in central nervous system (GO:0032291)3.32709771
30central nervous system myelination (GO:0022010)3.32709771
31potassium ion homeostasis (GO:0055075)3.31736395
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31236956
33ATP synthesis coupled proton transport (GO:0015986)3.31236956
34regulation of synapse structural plasticity (GO:0051823)3.30928530
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30267206
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22770525
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.21201520
38meiotic chromosome segregation (GO:0045132)3.20079777
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19697431
40righting reflex (GO:0060013)3.19607657
41cell proliferation in forebrain (GO:0021846)3.18996895
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16782188
43synaptic transmission, glutamatergic (GO:0035249)3.16506131
44neuron recognition (GO:0008038)3.15627746
45pyrimidine nucleobase catabolic process (GO:0006208)3.15445789
46axonal fasciculation (GO:0007413)3.14298755
47C4-dicarboxylate transport (GO:0015740)3.10250601
48transmission of nerve impulse (GO:0019226)3.09664905
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.09011200
50regulation of cilium movement (GO:0003352)3.07075634
51cell migration in hindbrain (GO:0021535)2.99218682
52neurotransmitter uptake (GO:0001504)2.97065751
53positive regulation of synapse assembly (GO:0051965)2.95593468
54oxidative demethylation (GO:0070989)2.94365723
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93978064
56response to auditory stimulus (GO:0010996)2.93158647
57regulation of membrane repolarization (GO:0060306)2.89546166
58response to pheromone (GO:0019236)2.87472250
59protein localization to synapse (GO:0035418)2.86264700
60neurofilament cytoskeleton organization (GO:0060052)2.85341030
61positive regulation of action potential (GO:0045760)2.85273859
62substrate-independent telencephalic tangential migration (GO:0021826)2.84536232
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.84536232
64resolution of meiotic recombination intermediates (GO:0000712)2.84343930
65ventricular system development (GO:0021591)2.80332906
66regulation of respiratory system process (GO:0044065)2.80162963
67membrane hyperpolarization (GO:0060081)2.79659150
68regulation of action potential (GO:0098900)2.77256929
69somite development (GO:0061053)2.73512292
70limb bud formation (GO:0060174)2.70708846
71viral protein processing (GO:0019082)2.70244557
72head development (GO:0060322)2.68258696
73regulation of vesicle fusion (GO:0031338)2.68254549
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67320465
75negative regulation of potassium ion transport (GO:0043267)2.67299282
76startle response (GO:0001964)2.66443831
77adult walking behavior (GO:0007628)2.66117897
78potassium ion import (GO:0010107)2.65324707
79protein complex biogenesis (GO:0070271)2.64006835
80dentate gyrus development (GO:0021542)2.63900872
81negative regulation of mast cell activation (GO:0033004)2.62074793
82negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61130461
83epithelial cilium movement (GO:0003351)2.60601069
84regulation of translation, ncRNA-mediated (GO:0045974)2.59025605
85negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59025605
86negative regulation of translation, ncRNA-mediated (GO:0040033)2.59025605
87positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.57185323
88ribosomal small subunit biogenesis (GO:0042274)2.56712769
89adult behavior (GO:0030534)2.56094198
90negative regulation of membrane potential (GO:0045837)2.55793511
91nucleobase catabolic process (GO:0046113)2.55575516
92regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54428611
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.53583745
94NADH dehydrogenase complex assembly (GO:0010257)2.53583745
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53583745
96neuronal action potential propagation (GO:0019227)2.53365828
97behavioral defense response (GO:0002209)2.52392197
98behavioral fear response (GO:0001662)2.52392197
99potassium ion export (GO:0071435)2.51141362
100estrogen biosynthetic process (GO:0006703)2.50440953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63953622
2IGF1R_20145208_ChIP-Seq_DFB_Human3.31638343
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.81061103
4GBX2_23144817_ChIP-Seq_PC3_Human2.73984861
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62504459
6VDR_22108803_ChIP-Seq_LS180_Human2.61439933
7TAF15_26573619_Chip-Seq_HEK293_Human2.46688484
8FUS_26573619_Chip-Seq_HEK293_Human2.43522431
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42208820
10RNF2_27304074_Chip-Seq_NSC_Mouse2.29006518
11REST_21632747_ChIP-Seq_MESCs_Mouse2.24645350
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.23928199
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19981117
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17907223
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13095529
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09732044
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09558716
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.09339585
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09098400
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06369990
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.04843326
22P300_19829295_ChIP-Seq_ESCs_Human1.95813114
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91070327
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88641736
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81057123
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80140273
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80140273
28ZNF274_21170338_ChIP-Seq_K562_Hela1.79203653
29AR_21572438_ChIP-Seq_LNCaP_Human1.73979280
30SMAD4_21799915_ChIP-Seq_A2780_Human1.73843684
31ER_23166858_ChIP-Seq_MCF-7_Human1.73416180
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71725149
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71025608
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.69356299
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68757350
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65933244
37EWS_26573619_Chip-Seq_HEK293_Human1.62254170
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.60963152
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.58487039
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.57191821
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56209799
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52312858
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51969044
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50675306
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.48209570
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46961034
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45971678
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43647921
49AR_25329375_ChIP-Seq_VCAP_Human1.43328494
50TCF4_23295773_ChIP-Seq_U87_Human1.41323199
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.41214844
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41127182
53BCAT_22108803_ChIP-Seq_LS180_Human1.40311444
54STAT3_23295773_ChIP-Seq_U87_Human1.38390149
55RUNX2_22187159_ChIP-Seq_PCA_Human1.37917852
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37349539
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35859027
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35378371
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35015007
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.33994747
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33877840
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33036740
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32156033
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31632222
65CBP_20019798_ChIP-Seq_JUKART_Human1.31474893
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31474893
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29736321
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28544207
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26388891
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25144173
71TP53_22573176_ChIP-Seq_HFKS_Human1.24796042
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24641140
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.21455614
74TCF4_22108803_ChIP-Seq_LS180_Human1.21239946
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.20291975
76KDM2B_26808549_Chip-Seq_REH_Human1.19224789
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.18965366
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18439246
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16755545
80JUN_21703547_ChIP-Seq_K562_Human1.15704367
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15665732
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13941834
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13507221
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.13281059
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11394334
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10827584
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10827584
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10414237
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08866187
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.08008514
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.07896282
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.06061686
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05805001
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05476053
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03964682
96SOX2_19829295_ChIP-Seq_ESCs_Human1.03420921
97NANOG_19829295_ChIP-Seq_ESCs_Human1.03420921
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01582784
99RXR_22108803_ChIP-Seq_LS180_Human1.00408385
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98496753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction3.44963079
2MP0005423_abnormal_somatic_nervous3.27193437
3MP0003880_abnormal_central_pattern3.08158822
4MP0001968_abnormal_touch/_nociception3.05949221
5MP0002736_abnormal_nociception_after2.61565817
6MP0009046_muscle_twitch2.55447316
7MP0009745_abnormal_behavioral_response2.51933111
8MP0004885_abnormal_endolymph2.49845567
9MP0004270_analgesia2.47007793
10MP0003787_abnormal_imprinting2.45509255
11MP0002272_abnormal_nervous_system2.38053302
12MP0001485_abnormal_pinna_reflex2.36322037
13MP0003635_abnormal_synaptic_transmissio2.35900137
14MP0008877_abnormal_DNA_methylation2.35457650
15MP0002734_abnormal_mechanical_nocicepti2.32282379
16MP0003011_delayed_dark_adaptation2.27402803
17MP0001486_abnormal_startle_reflex2.22232491
18MP0002064_seizures2.15588026
19MP0004859_abnormal_synaptic_plasticity2.15162531
20MP0001529_abnormal_vocalization2.13171185
21MP0000566_synostosis2.06531282
22MP0002733_abnormal_thermal_nociception2.05069834
23MP0002735_abnormal_chemical_nociception2.04861189
24MP0001970_abnormal_pain_threshold2.03694029
25MP0005551_abnormal_eye_electrophysiolog1.98408417
26MP0004142_abnormal_muscle_tone1.92894582
27MP0002063_abnormal_learning/memory/cond1.87030259
28MP0008875_abnormal_xenobiotic_pharmacok1.82502533
29MP0005171_absent_coat_pigmentation1.80999129
30MP0002572_abnormal_emotion/affect_behav1.79685561
31MP0003121_genomic_imprinting1.74818551
32MP0002067_abnormal_sensory_capabilities1.71044268
33MP0003122_maternal_imprinting1.63686402
34MP0008789_abnormal_olfactory_epithelium1.51924688
35MP0005499_abnormal_olfactory_system1.48859549
36MP0005394_taste/olfaction_phenotype1.48859549
37MP0000778_abnormal_nervous_system1.48673825
38MP0002638_abnormal_pupillary_reflex1.47632199
39MP0002234_abnormal_pharynx_morphology1.45621763
40MP0002160_abnormal_reproductive_system1.44252180
41MP0005386_behavior/neurological_phenoty1.43532529
42MP0004924_abnormal_behavior1.43532529
43MP0003123_paternal_imprinting1.42953205
44MP0002938_white_spotting1.41834609
45MP0004742_abnormal_vestibular_system1.38549420
46MP0000026_abnormal_inner_ear1.33970205
47MP0000631_abnormal_neuroendocrine_gland1.33639552
48MP0006292_abnormal_olfactory_placode1.32277066
49MP0000955_abnormal_spinal_cord1.32015432
50MP0003136_yellow_coat_color1.31559130
51MP0001905_abnormal_dopamine_level1.30525637
52MP0001963_abnormal_hearing_physiology1.29930632
53MP0005248_abnormal_Harderian_gland1.22951673
54MP0004133_heterotaxia1.22606911
55MP0001919_abnormal_reproductive_system1.22577862
56MP0009379_abnormal_foot_pigmentation1.20426221
57MP0005195_abnormal_posterior_eye1.19833078
58MP0001299_abnormal_eye_distance/1.19037946
59MP0001501_abnormal_sleep_pattern1.18648636
60MP0001440_abnormal_grooming_behavior1.18407998
61MP0000049_abnormal_middle_ear1.15433207
62MP0002882_abnormal_neuron_morphology1.14828973
63MP0002653_abnormal_ependyma_morphology1.14719720
64MP0003879_abnormal_hair_cell1.11827908
65MP0002752_abnormal_somatic_nervous1.10822310
66MP0002557_abnormal_social/conspecific_i1.09139865
67MP0002095_abnormal_skin_pigmentation1.05696669
68MP0005253_abnormal_eye_physiology1.05215498
69MP0000569_abnormal_digit_pigmentation1.04238823
70MP0002066_abnormal_motor_capabilities/c1.04110079
71MP0002229_neurodegeneration1.04082198
72MP0002152_abnormal_brain_morphology1.03344895
73MP0002184_abnormal_innervation0.98409206
74MP0005389_reproductive_system_phenotype0.96992967
75MP0006276_abnormal_autonomic_nervous0.96951306
76MP0003937_abnormal_limbs/digits/tail_de0.96171446
77MP0005379_endocrine/exocrine_gland_phen0.96005784
78MP0002102_abnormal_ear_morphology0.95951829
79MP0004134_abnormal_chest_morphology0.95868956
80MP0001324_abnormal_eye_pigmentation0.91448900
81MP0002233_abnormal_nose_morphology0.91332896
82MP0003633_abnormal_nervous_system0.89981053
83MP0003755_abnormal_palate_morphology0.88433418
84MP0002928_abnormal_bile_duct0.87016676
85MP0010386_abnormal_urinary_bladder0.85966180
86MP0004811_abnormal_neuron_physiology0.80998514
87MP0006072_abnormal_retinal_apoptosis0.80891713
88MP0003868_abnormal_feces_composition0.79664211
89MP0001286_abnormal_eye_development0.77755805
90MP0003646_muscle_fatigue0.77234464
91MP0003861_abnormal_nervous_system0.76971863
92MP0004145_abnormal_muscle_electrophysio0.76056677
93MP0005646_abnormal_pituitary_gland0.73584535
94MP0000647_abnormal_sebaceous_gland0.70915328
95MP0001188_hyperpigmentation0.70576552
96MP0006035_abnormal_mitochondrial_morpho0.69690337
97MP0002163_abnormal_gland_morphology0.69087886
98MP0003698_abnormal_male_reproductive0.68166081
99MP0003950_abnormal_plasma_membrane0.67910536
100MP0002837_dystrophic_cardiac_calcinosis0.67240086

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.12180489
2Gait imbalance (HP:0002141)4.32658576
3Medial flaring of the eyebrow (HP:0010747)4.29936306
4Congenital primary aphakia (HP:0007707)4.14909384
5Nephrogenic diabetes insipidus (HP:0009806)3.90890143
6Febrile seizures (HP:0002373)3.87148296
7Reticulocytopenia (HP:0001896)3.65039320
8Hyperventilation (HP:0002883)3.59965659
9Sensory axonal neuropathy (HP:0003390)3.59175051
10Molar tooth sign on MRI (HP:0002419)3.47243001
11Abnormality of midbrain morphology (HP:0002418)3.47243001
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.44887787
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.44887787
14Dialeptic seizures (HP:0011146)3.37693798
15Genital tract atresia (HP:0001827)3.37336979
16Poor coordination (HP:0002370)3.35110923
17Vaginal atresia (HP:0000148)3.31756166
18Hyperglycinemia (HP:0002154)3.16468095
19Atonic seizures (HP:0010819)3.15841183
20Absence seizures (HP:0002121)2.97646260
21Myokymia (HP:0002411)2.87731693
22Abnormality of the corticospinal tract (HP:0002492)2.85477239
23Pancreatic fibrosis (HP:0100732)2.83279938
24Congenital stationary night blindness (HP:0007642)2.68132720
25Focal seizures (HP:0007359)2.62533584
26Broad-based gait (HP:0002136)2.61153464
27Abnormal rod and cone electroretinograms (HP:0008323)2.51259644
28Methylmalonic acidemia (HP:0002912)2.48265967
29True hermaphroditism (HP:0010459)2.47783553
30Absent speech (HP:0001344)2.40310105
31Acute necrotizing encephalopathy (HP:0006965)2.39429417
32Large earlobe (HP:0009748)2.38356591
33Dyschromatopsia (HP:0007641)2.37136895
34Protruding tongue (HP:0010808)2.37120137
35Broad foot (HP:0001769)2.36213451
36Pancreatic cysts (HP:0001737)2.30977826
37Nephronophthisis (HP:0000090)2.26146886
38Aplasia/Hypoplasia of the lens (HP:0008063)2.25765839
39Drooling (HP:0002307)2.23103397
40Abnormal mitochondria in muscle tissue (HP:0008316)2.20938575
41Short foot (HP:0001773)2.19070645
42Prolonged QT interval (HP:0001657)2.18629295
43Morphological abnormality of the inner ear (HP:0011390)2.18601567
44Acute encephalopathy (HP:0006846)2.17243732
45Epileptic encephalopathy (HP:0200134)2.15465659
46Chronic hepatic failure (HP:0100626)2.14048176
47Type II lissencephaly (HP:0007260)2.13377472
48Abnormal drinking behavior (HP:0030082)2.12713603
49Polydipsia (HP:0001959)2.12713603
50Hepatocellular necrosis (HP:0001404)2.12658147
51Mitral stenosis (HP:0001718)2.10674886
52Progressive cerebellar ataxia (HP:0002073)2.09998508
53Methylmalonic aciduria (HP:0012120)2.09029448
54Postaxial foot polydactyly (HP:0001830)2.08885368
55Optic nerve hypoplasia (HP:0000609)2.07571148
56Septo-optic dysplasia (HP:0100842)2.07388459
57Abnormality of the labia minora (HP:0012880)2.07382335
58Increased circulating renin level (HP:0000848)2.06199202
59Decreased testicular size (HP:0008734)2.05964667
60Postaxial hand polydactyly (HP:0001162)2.05116834
61Abnormality of the phalanges of the hallux (HP:0010057)2.04779795
62Arthropathy (HP:0003040)2.03629025
63Partial duplication of thumb phalanx (HP:0009944)2.01808467
64Excessive salivation (HP:0003781)2.01694445
65Abnormal eating behavior (HP:0100738)2.00840838
66Abnormality of cochlea (HP:0000375)1.96409041
67Progressive macrocephaly (HP:0004481)1.96327614
68Colon cancer (HP:0003003)1.93988151
69Mitochondrial inheritance (HP:0001427)1.91754068
70Dysdiadochokinesis (HP:0002075)1.90061615
71Abnormal urine output (HP:0012590)1.89073146
72Optic disc pallor (HP:0000543)1.86777744
73Intellectual disability, severe (HP:0010864)1.85769120
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84693749
75Gaze-evoked nystagmus (HP:0000640)1.83960929
76Polyphagia (HP:0002591)1.83190667
77Genetic anticipation (HP:0003743)1.82545291
78Micropenis (HP:0000054)1.81995019
79Leukodystrophy (HP:0002415)1.81876293
80Abnormality of renal excretion (HP:0011036)1.79870439
81Hypomagnesemia (HP:0002917)1.79846427
82Spastic tetraplegia (HP:0002510)1.79088620
83Specific learning disability (HP:0001328)1.77762422
84Attenuation of retinal blood vessels (HP:0007843)1.77484815
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77465645
86Potter facies (HP:0002009)1.77065964
87Facial shape deformation (HP:0011334)1.77065964
88Generalized tonic-clonic seizures (HP:0002069)1.76148897
89Epidermoid cyst (HP:0200040)1.76005875
90Bony spicule pigmentary retinopathy (HP:0007737)1.74198565
91Impaired vibration sensation in the lower limbs (HP:0002166)1.74190397
92Hepatic necrosis (HP:0002605)1.73512180
93Retinitis pigmentosa (HP:0000510)1.73390354
94Urinary urgency (HP:0000012)1.72640023
95Esotropia (HP:0000565)1.71622275
96Spastic paraparesis (HP:0002313)1.71348604
97Abnormality of glycine metabolism (HP:0010895)1.71138180
98Abnormality of serine family amino acid metabolism (HP:0010894)1.71138180
99Cerebellar dysplasia (HP:0007033)1.70868072
100Hyperalaninemia (HP:0003348)1.70350873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.89515827
2CAMKK25.13516768
3MAP3K44.16216294
4MAP2K73.38804606
5MAP4K22.48110541
6TRIM282.41944880
7MAP3K62.26969821
8PINK12.23282985
9EPHA42.19221342
10MARK12.15915628
11SIK21.87371544
12CAMKK11.82744818
13SGK21.78626997
14WNK31.72747788
15MAP2K41.71906155
16PRKCG1.70478159
17ERBB31.66573477
18SGK4941.65409619
19SGK2231.65409619
20TYRO31.53301766
21TNIK1.52666837
22MAPK131.52408799
23FRK1.43480410
24CDK191.40535410
25ADRBK21.39707077
26CAMK41.39590339
27PLK21.38094322
28STK161.33045445
29IRAK21.25897046
30DAPK21.18990845
31PRKCZ1.18545241
32NTRK21.17871526
33BCR1.09911291
34CSNK1G11.07898295
35CSNK1G21.07808626
36OXSR11.07543415
37CAMK11.06659291
38SGK31.06450844
39UHMK11.05851236
40PRKCE1.05434092
41NUAK11.03801226
42CSNK1G31.02856043
43PNCK1.01917542
44MINK11.01562546
45CSNK1A1L1.00351866
46DYRK21.00249771
47BRD40.96403362
48GRK10.94171864
49CAMK2A0.91513096
50KSR10.91310354
51PDK20.86556438
52NTRK30.86310271
53PRKCQ0.84754458
54PAK30.80888357
55FER0.79630908
56CDK30.78836780
57MKNK20.78772118
58CDK50.76206214
59CAMK1D0.75128592
60CAMK1G0.74706264
61STK38L0.67500039
62DYRK1A0.65361885
63INSRR0.64909034
64CAMK2D0.64634364
65BMPR1B0.63057523
66SGK10.63052957
67PRKCI0.62532720
68PKN10.52183178
69MAP3K50.49674385
70PRKACA0.49666140
71ZAK0.48020426
72CAMK2B0.47746121
73STK390.46236334
74WNK40.42358305
75PRKACB0.41104374
76PRKCA0.40840264
77ABL20.40559844
78CDC70.38749008
79RPS6KA30.37377185
80ACVR1B0.36877336
81MARK30.35122843
82GRK70.35061537
83PRKCD0.34770863
84STK380.34108419
85CSNK1A10.33471789
86PRKCB0.31237384
87PAK60.30663771
88GRK50.29657648
89MAPKAPK50.28740595
90MAPK90.28466942
91STK30.25445887
92IRAK10.25189234
93CSNK1E0.24857559
94DYRK30.24526481
95SRPK10.24505301
96DAPK30.24201431
97PRKG10.23985675
98DAPK10.22270304
99ADRBK10.21868873
100CDK140.21324364

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.24720513
2Caffeine metabolism_Homo sapiens_hsa002323.32682737
3Oxidative phosphorylation_Homo sapiens_hsa001902.80427999
4GABAergic synapse_Homo sapiens_hsa047272.64354820
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40426601
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34920515
7Phototransduction_Homo sapiens_hsa047442.28727415
8Glutamatergic synapse_Homo sapiens_hsa047242.21774378
9Morphine addiction_Homo sapiens_hsa050322.19834498
10Taste transduction_Homo sapiens_hsa047422.17615802
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16056999
12Parkinsons disease_Homo sapiens_hsa050122.09499469
13Cardiac muscle contraction_Homo sapiens_hsa042602.01350853
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82888343
15Cocaine addiction_Homo sapiens_hsa050301.81441451
16Amphetamine addiction_Homo sapiens_hsa050311.73616654
17Propanoate metabolism_Homo sapiens_hsa006401.67907722
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61789183
19Synaptic vesicle cycle_Homo sapiens_hsa047211.58041983
20Dopaminergic synapse_Homo sapiens_hsa047281.57290590
21Collecting duct acid secretion_Homo sapiens_hsa049661.55950895
22Alzheimers disease_Homo sapiens_hsa050101.54331439
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52730637
24Huntingtons disease_Homo sapiens_hsa050161.46065973
25Protein export_Homo sapiens_hsa030601.43116193
26Circadian entrainment_Homo sapiens_hsa047131.42837439
27Butanoate metabolism_Homo sapiens_hsa006501.41971887
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39676219
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39189218
30Linoleic acid metabolism_Homo sapiens_hsa005911.29606267
31Long-term potentiation_Homo sapiens_hsa047201.29546531
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24907878
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22622786
34Tryptophan metabolism_Homo sapiens_hsa003801.20223238
35Serotonergic synapse_Homo sapiens_hsa047261.19895842
36Insulin secretion_Homo sapiens_hsa049111.19020401
37Fanconi anemia pathway_Homo sapiens_hsa034601.17276764
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13821443
39Non-homologous end-joining_Homo sapiens_hsa034501.08999962
40Salivary secretion_Homo sapiens_hsa049701.07847731
41Fatty acid biosynthesis_Homo sapiens_hsa000611.05140517
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04434375
43Dorso-ventral axis formation_Homo sapiens_hsa043201.00494121
44Calcium signaling pathway_Homo sapiens_hsa040200.99635418
45cAMP signaling pathway_Homo sapiens_hsa040240.96666712
46Regulation of autophagy_Homo sapiens_hsa041400.96341682
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95114813
48Renin secretion_Homo sapiens_hsa049240.90635469
49Gastric acid secretion_Homo sapiens_hsa049710.88400257
50Ribosome_Homo sapiens_hsa030100.87216971
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.86170476
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.84262780
53RNA degradation_Homo sapiens_hsa030180.84191411
54Olfactory transduction_Homo sapiens_hsa047400.83736637
55Peroxisome_Homo sapiens_hsa041460.82775766
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.81598090
57Cholinergic synapse_Homo sapiens_hsa047250.78938824
58Histidine metabolism_Homo sapiens_hsa003400.76828049
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76001824
60Fatty acid degradation_Homo sapiens_hsa000710.72341028
61Circadian rhythm_Homo sapiens_hsa047100.71944457
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70427911
63Chemical carcinogenesis_Homo sapiens_hsa052040.67736715
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66573850
65Retinol metabolism_Homo sapiens_hsa008300.66138732
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65547009
67Arginine and proline metabolism_Homo sapiens_hsa003300.64320759
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62851897
69Fatty acid metabolism_Homo sapiens_hsa012120.59785590
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59581536
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58859837
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56205493
73Basal transcription factors_Homo sapiens_hsa030220.55749401
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54340812
75Long-term depression_Homo sapiens_hsa047300.54077356
76Oxytocin signaling pathway_Homo sapiens_hsa049210.53864896
77beta-Alanine metabolism_Homo sapiens_hsa004100.51756672
78Gap junction_Homo sapiens_hsa045400.51198161
79Steroid biosynthesis_Homo sapiens_hsa001000.50418762
80Ether lipid metabolism_Homo sapiens_hsa005650.48755352
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48169021
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47192483
83Nitrogen metabolism_Homo sapiens_hsa009100.43597424
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43344200
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43084240
86Basal cell carcinoma_Homo sapiens_hsa052170.42204024
87Axon guidance_Homo sapiens_hsa043600.42203108
88Oocyte meiosis_Homo sapiens_hsa041140.40354393
89Ras signaling pathway_Homo sapiens_hsa040140.39683998
90Renin-angiotensin system_Homo sapiens_hsa046140.38203936
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37687210
92Hedgehog signaling pathway_Homo sapiens_hsa043400.37417856
93Hippo signaling pathway_Homo sapiens_hsa043900.37129981
94RNA polymerase_Homo sapiens_hsa030200.36601303
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36549727
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36197533
97Selenocompound metabolism_Homo sapiens_hsa004500.34795137
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33535282
99Metabolic pathways_Homo sapiens_hsa011000.33048664
100Alcoholism_Homo sapiens_hsa050340.31654739

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