HMGN1P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)7.48034681
2maturation of 5.8S rRNA (GO:0000460)6.72597076
3protein deneddylation (GO:0000338)6.58407477
4nuclear pore organization (GO:0006999)6.57904679
5synapsis (GO:0007129)6.44211440
6negative regulation of histone acetylation (GO:0035067)6.29821416
7nuclear pore complex assembly (GO:0051292)6.17059865
8negative regulation of protein acetylation (GO:1901984)5.50134132
9negative regulation of peptidyl-lysine acetylation (GO:2000757)5.05518919
10mitotic nuclear envelope disassembly (GO:0007077)5.04020550
11regulation of response to osmotic stress (GO:0047484)4.95734978
12resolution of meiotic recombination intermediates (GO:0000712)4.83396437
13regulation of DNA endoreduplication (GO:0032875)4.72366911
14pore complex assembly (GO:0046931)4.71638320
152-deoxyribonucleotide biosynthetic process (GO:0009265)4.59314204
16deoxyribose phosphate biosynthetic process (GO:0046385)4.59314204
17membrane disassembly (GO:0030397)4.59073080
18nuclear envelope disassembly (GO:0051081)4.59073080
19UDP-N-acetylglucosamine metabolic process (GO:0006047)4.42808156
20ribosome assembly (GO:0042255)4.42131685
21diterpenoid biosynthetic process (GO:0016102)4.38115310
22terpenoid biosynthetic process (GO:0016114)4.32203135
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.28541769
24oxidative phosphorylation (GO:0006119)4.11705073
25regulation of translational fidelity (GO:0006450)4.07625613
26intra-S DNA damage checkpoint (GO:0031573)3.91997550
27DNA replication initiation (GO:0006270)3.88375371
28protoporphyrinogen IX metabolic process (GO:0046501)3.79962331
29positive regulation of DNA-dependent DNA replication (GO:2000105)3.79211809
30DNA replication checkpoint (GO:0000076)3.76437468
31folic acid-containing compound biosynthetic process (GO:0009396)3.70687741
32biotin metabolic process (GO:0006768)3.70528374
33protein-DNA complex disassembly (GO:0032986)3.61219412
34nucleosome disassembly (GO:0006337)3.61219412
35IMP biosynthetic process (GO:0006188)3.57152284
36mitotic sister chromatid segregation (GO:0000070)3.55941716
37rRNA catabolic process (GO:0016075)3.54945798
38mitochondrial DNA replication (GO:0006264)3.50430136
39DNA catabolic process, exonucleolytic (GO:0000738)3.49000655
40response to pheromone (GO:0019236)3.48105318
41regulation of translational elongation (GO:0006448)3.47838885
42proteasome assembly (GO:0043248)3.46243736
43IMP metabolic process (GO:0046040)3.44496109
44N-terminal protein amino acid acetylation (GO:0006474)3.38817126
45rRNA methylation (GO:0031167)3.33742300
46deoxyribonucleotide biosynthetic process (GO:0009263)3.33603871
47pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.32085157
48microtubule severing (GO:0051013)3.31510553
49organelle disassembly (GO:1903008)3.29188439
50DNA replication-dependent nucleosome assembly (GO:0006335)3.29036589
51DNA replication-dependent nucleosome organization (GO:0034723)3.29036589
52DNA unwinding involved in DNA replication (GO:0006268)3.28716823
53rRNA modification (GO:0000154)3.28429634
54regulation of mitotic spindle organization (GO:0060236)3.24731028
55nuclear envelope organization (GO:0006998)3.24457013
56sister chromatid segregation (GO:0000819)3.22500910
57formation of translation preinitiation complex (GO:0001731)3.22248609
58definitive hemopoiesis (GO:0060216)3.22067956
59meiotic chromosome segregation (GO:0045132)3.21056656
60regulation of B cell apoptotic process (GO:0002902)3.18755989
61microtubule depolymerization (GO:0007019)3.16215028
62viral mRNA export from host cell nucleus (GO:0046784)3.15423717
63protoporphyrinogen IX biosynthetic process (GO:0006782)3.15138079
64gas transport (GO:0015669)3.13574266
65tetrahydrofolate metabolic process (GO:0046653)3.08406240
66attachment of spindle microtubules to kinetochore (GO:0008608)3.05911291
67regulation of histone H3-K4 methylation (GO:0051569)3.04919274
68oxygen transport (GO:0015671)3.03965984
69negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.02801086
70protein-cofactor linkage (GO:0018065)3.01084309
71lipopolysaccharide biosynthetic process (GO:0009103)2.99798909
72embryonic camera-type eye development (GO:0031076)2.98685014
73erythrocyte maturation (GO:0043249)2.93135558
74DNA methylation involved in gamete generation (GO:0043046)2.92747401
75DNA replication-independent nucleosome assembly (GO:0006336)2.92701972
76DNA replication-independent nucleosome organization (GO:0034724)2.92701972
77CENP-A containing nucleosome assembly (GO:0034080)2.91101858
78short-chain fatty acid metabolic process (GO:0046459)2.89481070
79mitochondrial DNA metabolic process (GO:0032042)2.86711482
80pseudouridine synthesis (GO:0001522)2.86491689
81chromosome organization involved in meiosis (GO:0070192)2.81640346
82purine nucleobase biosynthetic process (GO:0009113)2.81490584
83poly(A)+ mRNA export from nucleus (GO:0016973)2.79979128
84GMP metabolic process (GO:0046037)2.78256401
85nucleobase biosynthetic process (GO:0046112)2.76421302
86nucleotide-sugar biosynthetic process (GO:0009226)2.74648938
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72743393
88negative regulation of erythrocyte differentiation (GO:0045647)2.72255131
89organelle membrane fusion (GO:0090174)2.69050576
90erythrocyte development (GO:0048821)2.68754421
91chromatin remodeling at centromere (GO:0031055)2.66812716
92protein neddylation (GO:0045116)2.66032916
93transcription from mitochondrial promoter (GO:0006390)2.65904170
94histone exchange (GO:0043486)2.63892985
95mRNA cleavage (GO:0006379)2.62906193
96valine metabolic process (GO:0006573)2.61589783
97regulation of DNA-dependent DNA replication (GO:0090329)2.61528519
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60869739
99inner mitochondrial membrane organization (GO:0007007)2.58062177
100phagocytosis, recognition (GO:0006910)2.57584176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.68374570
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77315031
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32248212
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19906266
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.00978973
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.97562566
7ELK1_19687146_ChIP-ChIP_HELA_Human2.93720046
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88766362
9NCOR1_26117541_ChIP-Seq_K562_Human2.82345294
10GATA1_19941826_ChIP-Seq_K562_Human2.77236018
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76333665
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74055812
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71463695
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.63491128
15CIITA_25753668_ChIP-Seq_RAJI_Human2.60409446
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42084047
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40126076
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.34461246
19VDR_22108803_ChIP-Seq_LS180_Human2.32218668
20AR_21909140_ChIP-Seq_LNCAP_Human2.27495934
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.27289796
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.22513414
23VDR_23849224_ChIP-Seq_CD4+_Human2.01837048
24GATA2_19941826_ChIP-Seq_K562_Human2.00130406
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92942827
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88775109
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84172277
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83228932
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80286072
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79099975
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72019494
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71815433
33FOXP3_21729870_ChIP-Seq_TREG_Human1.71602634
34ZNF263_19887448_ChIP-Seq_K562_Human1.68869241
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63981066
36GATA6_21074721_ChIP-Seq_CACO-2_Human1.62981450
37GATA1_22025678_ChIP-Seq_K562_Human1.61591511
38GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.59806377
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58845195
40TTF2_22483619_ChIP-Seq_HELA_Human1.58589576
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58556205
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55195735
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54343777
44DCP1A_22483619_ChIP-Seq_HELA_Human1.53840498
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52988016
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50927602
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50771365
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50329107
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.50066811
50XRN2_22483619_ChIP-Seq_HELA_Human1.49802266
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46750853
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46527726
53PHF8_20622853_ChIP-Seq_HELA_Human1.46431279
54RBPJ_21746931_ChIP-Seq_IB4_Human1.45432949
55GABP_19822575_ChIP-Seq_HepG2_Human1.45415693
56HNFA_21074721_ChIP-Seq_CACO-2_Human1.45251725
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41422974
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40810952
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40105830
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.38582163
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37796856
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37124832
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36962433
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.35469740
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29420037
66ETS1_22383799_ChIP-Seq_G1ME_Mouse1.28534151
67ETV1_20927104_ChIP-Seq_GIST48_Human1.28470383
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24127225
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19668924
70KDM5A_27292631_Chip-Seq_BREAST_Human1.17716274
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16437144
72MYC_18940864_ChIP-ChIP_HL60_Human1.12474630
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11878179
74NFYA_21822215_ChIP-Seq_K562_Human1.11661005
75IGF1R_20145208_ChIP-Seq_DFB_Human1.11465065
76SPI1_23127762_ChIP-Seq_K562_Human1.08739557
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08210383
78EWS_26573619_Chip-Seq_HEK293_Human1.05481587
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04911620
80NFYB_21822215_ChIP-Seq_K562_Human1.04416836
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02313128
82SCL_19346495_ChIP-Seq_HPC-7_Human1.02100608
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.00939897
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00174061
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99609343
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98825140
87WT1_19549856_ChIP-ChIP_CCG9911_Human0.97449533
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.96664857
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96533826
90ELF5_23300383_ChIP-Seq_T47D_Human0.94358736
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94070560
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93180740
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92879763
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91865212
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91849184
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91823578
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89241555
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.86560669
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86470754
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85927304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.95733607
2MP0003786_premature_aging3.38523363
3MP0008995_early_reproductive_senescence3.36681816
4MP0009697_abnormal_copulation3.14837013
5MP0002132_abnormal_respiratory_system3.01918377
6MP0008007_abnormal_cellular_replicative2.92680487
7MP0004957_abnormal_blastocyst_morpholog2.91243874
8MP0003718_maternal_effect2.74766374
9MP0006036_abnormal_mitochondrial_physio2.61370288
10MP0004134_abnormal_chest_morphology2.49871496
11MP0003806_abnormal_nucleotide_metabolis2.49135109
12MP0003950_abnormal_plasma_membrane2.43909913
13MP0001542_abnormal_bone_strength2.42353173
14MP0004145_abnormal_muscle_electrophysio2.12826240
15MP0008058_abnormal_DNA_repair2.10110497
16MP0004084_abnormal_cardiac_muscle2.08241249
17MP0000749_muscle_degeneration2.07244560
18MP0008932_abnormal_embryonic_tissue2.04939731
19MP0010094_abnormal_chromosome_stability2.03814481
20MP0005646_abnormal_pituitary_gland2.03049331
21MP0000678_abnormal_parathyroid_gland2.01350079
22MP0006035_abnormal_mitochondrial_morpho1.99827134
23MP0005275_abnormal_skin_tensile1.93193656
24MP0003111_abnormal_nucleus_morphology1.89547020
25MP0005360_urolithiasis1.87931383
26MP0009780_abnormal_chondrocyte_physiolo1.83931654
27MP0003186_abnormal_redox_activity1.83491545
28MP0005503_abnormal_tendon_morphology1.75896303
29MP0003656_abnormal_erythrocyte_physiolo1.75527862
30MP0008775_abnormal_heart_ventricle1.75261849
31MP0000681_abnormal_thyroid_gland1.75036456
32MP0002837_dystrophic_cardiac_calcinosis1.61592764
33MP0005464_abnormal_platelet_physiology1.60828104
34MP0008438_abnormal_cutaneous_collagen1.57796049
35MP0002876_abnormal_thyroid_physiology1.56988746
36MP0006292_abnormal_olfactory_placode1.55876541
37MP0010307_abnormal_tumor_latency1.50311282
38MP0000372_irregular_coat_pigmentation1.35416063
39MP0002396_abnormal_hematopoietic_system1.34835156
40MP0005083_abnormal_biliary_tract1.34414941
41MP0002736_abnormal_nociception_after1.33807380
42MP0004036_abnormal_muscle_relaxation1.33072256
43MP0003195_calcinosis1.32307063
44MP0005389_reproductive_system_phenotype1.31208480
45MP0002210_abnormal_sex_determination1.28304875
46MP0002160_abnormal_reproductive_system1.20086052
47MP0001929_abnormal_gametogenesis1.18678825
48MP0005171_absent_coat_pigmentation1.15372291
49MP0003077_abnormal_cell_cycle1.15026745
50MP0002138_abnormal_hepatobiliary_system1.11165270
51MP0003137_abnormal_impulse_conducting1.10243797
52MP0002102_abnormal_ear_morphology1.07123842
53MP0000358_abnormal_cell_content/1.07067788
54MP0001661_extended_life_span1.06500057
55MP0005410_abnormal_fertilization1.06458999
56MP0003693_abnormal_embryo_hatching1.06228359
57MP0005332_abnormal_amino_acid1.04448741
58MP0000653_abnormal_sex_gland1.04267700
59MP0000465_gastrointestinal_hemorrhage1.02896119
60MP0001881_abnormal_mammary_gland0.98713992
61MP0008057_abnormal_DNA_replication0.97239600
62MP0000230_abnormal_systemic_arterial0.96110020
63MP0005397_hematopoietic_system_phenotyp0.95981066
64MP0001545_abnormal_hematopoietic_system0.95981066
65MP0008872_abnormal_physiological_respon0.95517165
66MP0003646_muscle_fatigue0.94412713
67MP0005451_abnormal_body_composition0.92163284
68MP0004215_abnormal_myocardial_fiber0.90803436
69MP0001697_abnormal_embryo_size0.90106736
70MP0001919_abnormal_reproductive_system0.89737427
71MP0000350_abnormal_cell_proliferation0.86373958
72MP0004808_abnormal_hematopoietic_stem0.85178364
73MP0001119_abnormal_female_reproductive0.84972900
74MP0005395_other_phenotype0.84891003
75MP0005535_abnormal_body_temperature0.83467001
76MP0002139_abnormal_hepatobiliary_system0.83135454
77MP0003698_abnormal_male_reproductive0.82906366
78MP0001145_abnormal_male_reproductive0.82890311
79MP0006072_abnormal_retinal_apoptosis0.82693905
80MP0005636_abnormal_mineral_homeostasis0.82249275
81MP0001243_abnormal_dermal_layer0.81187039
82MP0002019_abnormal_tumor_incidence0.79897704
83MP0001730_embryonic_growth_arrest0.79751912
84MP0001764_abnormal_homeostasis0.79102295
85MP0000313_abnormal_cell_death0.75749600
86MP0009643_abnormal_urine_homeostasis0.73500747
87MP0000747_muscle_weakness0.72768491
88MP0002080_prenatal_lethality0.72045000
89MP0001485_abnormal_pinna_reflex0.71901720
90MP0005385_cardiovascular_system_phenoty0.71700237
91MP0001544_abnormal_cardiovascular_syste0.71700237
92MP0003942_abnormal_urinary_system0.71203713
93MP0003959_abnormal_lean_body0.69780458
94MP0004883_abnormal_blood_vessel0.68624831
95MP0008789_abnormal_olfactory_epithelium0.67538347
96MP0001968_abnormal_touch/_nociception0.67016128
97MP0000703_abnormal_thymus_morphology0.65493773
98MP0002234_abnormal_pharynx_morphology0.63509545
99MP0001756_abnormal_urination0.61029290
100MP0002161_abnormal_fertility/fecundity0.60738190

Predicted human phenotypes

RankGene SetZ-score
1Hyperthyroidism (HP:0000836)6.09180560
2Abnormal gallbladder physiology (HP:0012438)5.68928770
3Cholecystitis (HP:0001082)5.68928770
4Truncus arteriosus (HP:0001660)5.29730185
5Hyperglycinemia (HP:0002154)4.64246502
6Hyperglycinuria (HP:0003108)4.19877883
7Acute encephalopathy (HP:0006846)3.99252507
8Hypertensive crisis (HP:0100735)3.98719757
9Limb hypertonia (HP:0002509)3.91270076
10Polycythemia (HP:0001901)3.82259054
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63109821
12Termporal pattern (HP:0011008)3.53479814
13Insidious onset (HP:0003587)3.53479814
14Chromsome breakage (HP:0040012)3.46903046
15Prolonged bleeding time (HP:0003010)3.46784961
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.43451350
17Increased serum pyruvate (HP:0003542)3.36212954
18Abnormality of glycolysis (HP:0004366)3.21142832
19Abnormal hemoglobin (HP:0011902)3.12307808
20Abnormality of the tricuspid valve (HP:0001702)3.09166907
21Seborrheic dermatitis (HP:0001051)3.07591517
22Reticulocytosis (HP:0001923)3.07577149
23Ankyloglossia (HP:0010296)3.02849870
24Spinal muscular atrophy (HP:0007269)3.02260048
25Cholelithiasis (HP:0001081)3.01469799
26Menorrhagia (HP:0000132)2.97523091
27Redundant skin (HP:0001582)2.97206910
28Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.88855303
29Metaphyseal dysplasia (HP:0100255)2.87902356
30Abnormality of serine family amino acid metabolism (HP:0010894)2.86972108
31Abnormality of glycine metabolism (HP:0010895)2.86972108
32Hyperammonemia (HP:0001987)2.86613885
33Abnormal platelet function (HP:0011869)2.81680864
34Impaired platelet aggregation (HP:0003540)2.81680864
35Abnormal large intestine physiology (HP:0012700)2.79518985
36Duplicated collecting system (HP:0000081)2.78860310
37Bowel incontinence (HP:0002607)2.76808019
38Poikilocytosis (HP:0004447)2.75165785
39Poor head control (HP:0002421)2.71280513
40Acute myeloid leukemia (HP:0004808)2.70671028
41Abnormal gallbladder morphology (HP:0012437)2.61963175
42Pancytopenia (HP:0001876)2.61960589
43Abnormality of reticulocytes (HP:0004312)2.60049071
44Upper limb muscle weakness (HP:0003484)2.59912612
45Male infertility (HP:0003251)2.56689768
46Abnormality of the anterior horn cell (HP:0006802)2.54554181
47Degeneration of anterior horn cells (HP:0002398)2.54554181
48Abnormality of the renal collecting system (HP:0004742)2.51544380
49Long clavicles (HP:0000890)2.47801408
50Venous insufficiency (HP:0005293)2.46840147
51Atelectasis (HP:0100750)2.45814914
52Hepatocellular carcinoma (HP:0001402)2.44893556
53Aplastic anemia (HP:0001915)2.43337925
54Short tibia (HP:0005736)2.43094300
55Abnormal lung lobation (HP:0002101)2.43001787
56Ileus (HP:0002595)2.42982649
57Genetic anticipation (HP:0003743)2.42967264
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.35822546
59Hepatocellular necrosis (HP:0001404)2.34340813
60Abnormality of oral frenula (HP:0000190)2.34007687
61Cerebral edema (HP:0002181)2.33347523
62Abnormality of serum amino acid levels (HP:0003112)2.29323820
63Myelodysplasia (HP:0002863)2.29114282
64Aplasia/Hypoplasia of the earlobes (HP:0009906)2.26404909
65Submucous cleft hard palate (HP:0000176)2.25441500
66Supernumerary spleens (HP:0009799)2.24453553
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24195293
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.24195293
69Hepatic necrosis (HP:0002605)2.20183152
70Cerebral palsy (HP:0100021)2.15425699
71Abnormality of the corticospinal tract (HP:0002492)2.11214609
72Increased CSF lactate (HP:0002490)2.10331302
73Cerebral hemorrhage (HP:0001342)2.09533784
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.07010538
75Abnormality of DNA repair (HP:0003254)2.05002994
76Back pain (HP:0003418)2.04437442
77Flat cornea (HP:0007720)2.01875552
78Acute necrotizing encephalopathy (HP:0006965)2.01369743
79Tinnitus (HP:0000360)2.00632084
80Acanthocytosis (HP:0001927)1.96130100
81Mitochondrial inheritance (HP:0001427)1.93406984
82Abnormality of the gallbladder (HP:0005264)1.93086275
83Venous abnormality (HP:0002624)1.92867268
84Median cleft lip (HP:0000161)1.92471405
85Short middle phalanx of the 5th finger (HP:0004220)1.92366218
86Hyperbilirubinemia (HP:0002904)1.92292563
87Secondary amenorrhea (HP:0000869)1.90920971
88Duodenal stenosis (HP:0100867)1.90708918
89Small intestinal stenosis (HP:0012848)1.90708918
90Increased mean platelet volume (HP:0011877)1.86819361
91Abnormality of the pons (HP:0007361)1.86294704
92Increased serum lactate (HP:0002151)1.84913522
93Hypoparathyroidism (HP:0000829)1.84459618
94Esophageal neoplasm (HP:0100751)1.84203432
95Neoplasm of head and neck (HP:0012288)1.84203432
96Small hand (HP:0200055)1.84004965
97Abnormally folded helix (HP:0008544)1.83591725
98Abnormality of the costochondral junction (HP:0000919)1.83479434
99Nausea (HP:0002018)1.83472741
100Nonimmune hydrops fetalis (HP:0001790)1.83214686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.62389360
2EIF2AK35.18958556
3STK394.05193967
4MKNK23.88491270
5BUB13.69461612
6ACVR1B3.59113472
7RIPK43.33623058
8OXSR12.77402987
9MKNK12.60498564
10NEK12.53914217
11RAF12.08656928
12PLK42.06534726
13BMPR22.06314727
14PLK21.98945240
15STK161.86117590
16CLK11.65317580
17WEE11.56593794
18MAP3K21.47020549
19EIF2AK21.45370491
20NTRK31.44941270
21KSR21.43195973
22WNK41.41697449
23MST41.41587025
24NME11.36339305
25TTK1.21287139
26CDC71.18825942
27STK31.12608060
28BCR1.10342402
29PLK31.03703659
30TESK20.99752544
31MAP3K80.94613499
32NUAK10.94568861
33ILK0.94468813
34MAP2K10.90340338
35BMX0.85277413
36TLK10.84720717
37TSSK60.84437925
38EEF2K0.83409576
39TEC0.79985746
40CCNB10.77456283
41MAPKAPK30.74348759
42MYLK0.74309220
43PAK10.71514889
44WNK10.70573930
45RPS6KA50.69983668
46KSR10.69909654
47BRSK20.68139386
48PAK40.66178666
49ERBB30.64502328
50NEK20.63942415
51KDR0.63792715
52TRPM70.63671009
53PHKG20.62366276
54PHKG10.62366276
55RPS6KA40.61268763
56DMPK0.59054000
57MINK10.56603055
58BRD40.53503338
59PIK3CG0.51740445
60ROCK10.46270503
61CSNK2A10.46240524
62PLK10.44149010
63MAPKAPK50.43814512
64CSNK2A20.42168459
65CHEK10.42139151
66MUSK0.41649214
67ATM0.41551787
68ALK0.40873656
69BTK0.36141682
70IRAK30.35955715
71CHEK20.35442102
72CDK10.34777972
73CSNK1E0.34019734
74PIM20.33835414
75ATR0.33062156
76CDK20.32043359
77GRK50.31997018
78LRRK20.31554183
79MAP2K20.31321334
80SCYL20.30688591
81PTK2B0.30557229
82PIM10.29765257
83MAP3K120.29258861
84INSRR0.28883249
85PDK20.26975340
86CDK80.24866268
87JAK20.24406424
88TYRO30.24367258
89RET0.23166749
90IRAK10.22492711
91AURKB0.21623511
92DYRK30.21574792
93ADRBK20.20346600
94PTK60.20200392
95SRPK10.20176982
96STK40.20165333
97PRKACG0.20047903
98GRK70.18785995
99TAOK30.18596648
100PAK20.18585444

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.77146410
2Proteasome_Homo sapiens_hsa030503.59082435
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.56910756
4Sulfur metabolism_Homo sapiens_hsa009203.40224938
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30524418
6Propanoate metabolism_Homo sapiens_hsa006403.27302617
7RNA transport_Homo sapiens_hsa030133.24045118
8DNA replication_Homo sapiens_hsa030302.99461187
9Mismatch repair_Homo sapiens_hsa034302.90924837
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.75758130
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73566729
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20698102
13Spliceosome_Homo sapiens_hsa030402.18560781
14Basal transcription factors_Homo sapiens_hsa030222.17721012
15Parkinsons disease_Homo sapiens_hsa050121.98616907
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91211618
17Homologous recombination_Homo sapiens_hsa034401.77708375
18RNA degradation_Homo sapiens_hsa030181.68504189
19Oxidative phosphorylation_Homo sapiens_hsa001901.67424796
20RNA polymerase_Homo sapiens_hsa030201.63533063
21Carbon metabolism_Homo sapiens_hsa012001.60839375
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50552162
23Selenocompound metabolism_Homo sapiens_hsa004501.49601351
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48415936
25Nucleotide excision repair_Homo sapiens_hsa034201.44024789
26Protein export_Homo sapiens_hsa030601.41389521
27Pyruvate metabolism_Homo sapiens_hsa006201.35963169
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35754159
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34591048
30Huntingtons disease_Homo sapiens_hsa050161.29863724
31Cell cycle_Homo sapiens_hsa041101.27310027
32Fanconi anemia pathway_Homo sapiens_hsa034601.24671104
33Nitrogen metabolism_Homo sapiens_hsa009101.21118113
34Pyrimidine metabolism_Homo sapiens_hsa002401.16443952
35Olfactory transduction_Homo sapiens_hsa047401.16196417
36mRNA surveillance pathway_Homo sapiens_hsa030151.02823923
37Alzheimers disease_Homo sapiens_hsa050101.00605461
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99590647
39Oocyte meiosis_Homo sapiens_hsa041140.99171087
40Purine metabolism_Homo sapiens_hsa002300.99044794
41Butanoate metabolism_Homo sapiens_hsa006500.97224327
42Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94673981
43mTOR signaling pathway_Homo sapiens_hsa041500.94254427
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91173004
45Glutathione metabolism_Homo sapiens_hsa004800.82526698
46Caffeine metabolism_Homo sapiens_hsa002320.79144534
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78834835
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.74903465
49Linoleic acid metabolism_Homo sapiens_hsa005910.74103737
50p53 signaling pathway_Homo sapiens_hsa041150.72106252
51Platelet activation_Homo sapiens_hsa046110.68898121
52Biosynthesis of amino acids_Homo sapiens_hsa012300.65890473
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65852240
54Metabolic pathways_Homo sapiens_hsa011000.62797424
55Retinol metabolism_Homo sapiens_hsa008300.62611918
56Arginine and proline metabolism_Homo sapiens_hsa003300.58668619
57Epstein-Barr virus infection_Homo sapiens_hsa051690.58154257
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.57722356
59HIF-1 signaling pathway_Homo sapiens_hsa040660.57628363
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57594346
61Steroid biosynthesis_Homo sapiens_hsa001000.55869883
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53536382
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52473530
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.49165567
65Glycerolipid metabolism_Homo sapiens_hsa005610.47218536
66Type II diabetes mellitus_Homo sapiens_hsa049300.47078920
67Melanoma_Homo sapiens_hsa052180.47038059
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46302332
69Fatty acid metabolism_Homo sapiens_hsa012120.46027979
70Arginine biosynthesis_Homo sapiens_hsa002200.45997577
71Malaria_Homo sapiens_hsa051440.45714560
72beta-Alanine metabolism_Homo sapiens_hsa004100.44952042
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41563787
74Shigellosis_Homo sapiens_hsa051310.41110320
75Pentose phosphate pathway_Homo sapiens_hsa000300.39546678
76Viral carcinogenesis_Homo sapiens_hsa052030.38678640
77Cardiac muscle contraction_Homo sapiens_hsa042600.37571180
78Acute myeloid leukemia_Homo sapiens_hsa052210.34295772
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33993497
80Fat digestion and absorption_Homo sapiens_hsa049750.32341471
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29821800
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29148972
83Fatty acid elongation_Homo sapiens_hsa000620.29118884
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27636760
85Herpes simplex infection_Homo sapiens_hsa051680.26818423
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25443836
87Hematopoietic cell lineage_Homo sapiens_hsa046400.25059848
88Non-homologous end-joining_Homo sapiens_hsa034500.24638075
89Phototransduction_Homo sapiens_hsa047440.23390275
90Insulin signaling pathway_Homo sapiens_hsa049100.22792225
91Peroxisome_Homo sapiens_hsa041460.21735912
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21097738
93Arachidonic acid metabolism_Homo sapiens_hsa005900.20966162
94Ribosome_Homo sapiens_hsa030100.20272354
95N-Glycan biosynthesis_Homo sapiens_hsa005100.20237578
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20159169
97Ether lipid metabolism_Homo sapiens_hsa005650.19442845
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18150111
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17839852
100Chemical carcinogenesis_Homo sapiens_hsa052040.17327921

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