Rank | Gene Set | Z-score |
---|---|---|
1 | cullin deneddylation (GO:0010388) | 7.48034681 |
2 | maturation of 5.8S rRNA (GO:0000460) | 6.72597076 |
3 | protein deneddylation (GO:0000338) | 6.58407477 |
4 | nuclear pore organization (GO:0006999) | 6.57904679 |
5 | synapsis (GO:0007129) | 6.44211440 |
6 | negative regulation of histone acetylation (GO:0035067) | 6.29821416 |
7 | nuclear pore complex assembly (GO:0051292) | 6.17059865 |
8 | negative regulation of protein acetylation (GO:1901984) | 5.50134132 |
9 | negative regulation of peptidyl-lysine acetylation (GO:2000757) | 5.05518919 |
10 | mitotic nuclear envelope disassembly (GO:0007077) | 5.04020550 |
11 | regulation of response to osmotic stress (GO:0047484) | 4.95734978 |
12 | resolution of meiotic recombination intermediates (GO:0000712) | 4.83396437 |
13 | regulation of DNA endoreduplication (GO:0032875) | 4.72366911 |
14 | pore complex assembly (GO:0046931) | 4.71638320 |
15 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 4.59314204 |
16 | deoxyribose phosphate biosynthetic process (GO:0046385) | 4.59314204 |
17 | membrane disassembly (GO:0030397) | 4.59073080 |
18 | nuclear envelope disassembly (GO:0051081) | 4.59073080 |
19 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 4.42808156 |
20 | ribosome assembly (GO:0042255) | 4.42131685 |
21 | diterpenoid biosynthetic process (GO:0016102) | 4.38115310 |
22 | terpenoid biosynthetic process (GO:0016114) | 4.32203135 |
23 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.28541769 |
24 | oxidative phosphorylation (GO:0006119) | 4.11705073 |
25 | regulation of translational fidelity (GO:0006450) | 4.07625613 |
26 | intra-S DNA damage checkpoint (GO:0031573) | 3.91997550 |
27 | DNA replication initiation (GO:0006270) | 3.88375371 |
28 | protoporphyrinogen IX metabolic process (GO:0046501) | 3.79962331 |
29 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 3.79211809 |
30 | DNA replication checkpoint (GO:0000076) | 3.76437468 |
31 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.70687741 |
32 | biotin metabolic process (GO:0006768) | 3.70528374 |
33 | protein-DNA complex disassembly (GO:0032986) | 3.61219412 |
34 | nucleosome disassembly (GO:0006337) | 3.61219412 |
35 | IMP biosynthetic process (GO:0006188) | 3.57152284 |
36 | mitotic sister chromatid segregation (GO:0000070) | 3.55941716 |
37 | rRNA catabolic process (GO:0016075) | 3.54945798 |
38 | mitochondrial DNA replication (GO:0006264) | 3.50430136 |
39 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.49000655 |
40 | response to pheromone (GO:0019236) | 3.48105318 |
41 | regulation of translational elongation (GO:0006448) | 3.47838885 |
42 | proteasome assembly (GO:0043248) | 3.46243736 |
43 | IMP metabolic process (GO:0046040) | 3.44496109 |
44 | N-terminal protein amino acid acetylation (GO:0006474) | 3.38817126 |
45 | rRNA methylation (GO:0031167) | 3.33742300 |
46 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.33603871 |
47 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.32085157 |
48 | microtubule severing (GO:0051013) | 3.31510553 |
49 | organelle disassembly (GO:1903008) | 3.29188439 |
50 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.29036589 |
51 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.29036589 |
52 | DNA unwinding involved in DNA replication (GO:0006268) | 3.28716823 |
53 | rRNA modification (GO:0000154) | 3.28429634 |
54 | regulation of mitotic spindle organization (GO:0060236) | 3.24731028 |
55 | nuclear envelope organization (GO:0006998) | 3.24457013 |
56 | sister chromatid segregation (GO:0000819) | 3.22500910 |
57 | formation of translation preinitiation complex (GO:0001731) | 3.22248609 |
58 | definitive hemopoiesis (GO:0060216) | 3.22067956 |
59 | meiotic chromosome segregation (GO:0045132) | 3.21056656 |
60 | regulation of B cell apoptotic process (GO:0002902) | 3.18755989 |
61 | microtubule depolymerization (GO:0007019) | 3.16215028 |
62 | viral mRNA export from host cell nucleus (GO:0046784) | 3.15423717 |
63 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.15138079 |
64 | gas transport (GO:0015669) | 3.13574266 |
65 | tetrahydrofolate metabolic process (GO:0046653) | 3.08406240 |
66 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.05911291 |
67 | regulation of histone H3-K4 methylation (GO:0051569) | 3.04919274 |
68 | oxygen transport (GO:0015671) | 3.03965984 |
69 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 3.02801086 |
70 | protein-cofactor linkage (GO:0018065) | 3.01084309 |
71 | lipopolysaccharide biosynthetic process (GO:0009103) | 2.99798909 |
72 | embryonic camera-type eye development (GO:0031076) | 2.98685014 |
73 | erythrocyte maturation (GO:0043249) | 2.93135558 |
74 | DNA methylation involved in gamete generation (GO:0043046) | 2.92747401 |
75 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.92701972 |
76 | DNA replication-independent nucleosome organization (GO:0034724) | 2.92701972 |
77 | CENP-A containing nucleosome assembly (GO:0034080) | 2.91101858 |
78 | short-chain fatty acid metabolic process (GO:0046459) | 2.89481070 |
79 | mitochondrial DNA metabolic process (GO:0032042) | 2.86711482 |
80 | pseudouridine synthesis (GO:0001522) | 2.86491689 |
81 | chromosome organization involved in meiosis (GO:0070192) | 2.81640346 |
82 | purine nucleobase biosynthetic process (GO:0009113) | 2.81490584 |
83 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.79979128 |
84 | GMP metabolic process (GO:0046037) | 2.78256401 |
85 | nucleobase biosynthetic process (GO:0046112) | 2.76421302 |
86 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.74648938 |
87 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.72743393 |
88 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.72255131 |
89 | organelle membrane fusion (GO:0090174) | 2.69050576 |
90 | erythrocyte development (GO:0048821) | 2.68754421 |
91 | chromatin remodeling at centromere (GO:0031055) | 2.66812716 |
92 | protein neddylation (GO:0045116) | 2.66032916 |
93 | transcription from mitochondrial promoter (GO:0006390) | 2.65904170 |
94 | histone exchange (GO:0043486) | 2.63892985 |
95 | mRNA cleavage (GO:0006379) | 2.62906193 |
96 | valine metabolic process (GO:0006573) | 2.61589783 |
97 | regulation of DNA-dependent DNA replication (GO:0090329) | 2.61528519 |
98 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.60869739 |
99 | inner mitochondrial membrane organization (GO:0007007) | 2.58062177 |
100 | phagocytosis, recognition (GO:0006910) | 2.57584176 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.68374570 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.77315031 |
3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.32248212 |
4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.19906266 |
5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.00978973 |
6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.97562566 |
7 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.93720046 |
8 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.88766362 |
9 | NCOR1_26117541_ChIP-Seq_K562_Human | 2.82345294 |
10 | GATA1_19941826_ChIP-Seq_K562_Human | 2.77236018 |
11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.76333665 |
12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.74055812 |
13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.71463695 |
14 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.63491128 |
15 | CIITA_25753668_ChIP-Seq_RAJI_Human | 2.60409446 |
16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.42084047 |
17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.40126076 |
18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.34461246 |
19 | VDR_22108803_ChIP-Seq_LS180_Human | 2.32218668 |
20 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.27495934 |
21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.27289796 |
22 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.22513414 |
23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.01837048 |
24 | GATA2_19941826_ChIP-Seq_K562_Human | 2.00130406 |
25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.92942827 |
26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.88775109 |
27 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.84172277 |
28 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.83228932 |
29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.80286072 |
30 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.79099975 |
31 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.72019494 |
32 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.71815433 |
33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.71602634 |
34 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.68869241 |
35 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.63981066 |
36 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.62981450 |
37 | GATA1_22025678_ChIP-Seq_K562_Human | 1.61591511 |
38 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.59806377 |
39 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.58845195 |
40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.58589576 |
41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.58556205 |
42 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.55195735 |
43 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.54343777 |
44 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.53840498 |
45 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.52988016 |
46 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.50927602 |
47 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.50771365 |
48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.50329107 |
49 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.50066811 |
50 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.49802266 |
51 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.46750853 |
52 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.46527726 |
53 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.46431279 |
54 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.45432949 |
55 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.45415693 |
56 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.45251725 |
57 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.41422974 |
58 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40810952 |
59 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.40105830 |
60 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.38582163 |
61 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.37796856 |
62 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.37124832 |
63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.36962433 |
64 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.35469740 |
65 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.29420037 |
66 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 1.28534151 |
67 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.28470383 |
68 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.24127225 |
69 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.19668924 |
70 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.17716274 |
71 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.16437144 |
72 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.12474630 |
73 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.11878179 |
74 | NFYA_21822215_ChIP-Seq_K562_Human | 1.11661005 |
75 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.11465065 |
76 | SPI1_23127762_ChIP-Seq_K562_Human | 1.08739557 |
77 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.08210383 |
78 | EWS_26573619_Chip-Seq_HEK293_Human | 1.05481587 |
79 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.04911620 |
80 | NFYB_21822215_ChIP-Seq_K562_Human | 1.04416836 |
81 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.02313128 |
82 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.02100608 |
83 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.00939897 |
84 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.00174061 |
85 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.99609343 |
86 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.98825140 |
87 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.97449533 |
88 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.96664857 |
89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96533826 |
90 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.94358736 |
91 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94070560 |
92 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93180740 |
93 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92879763 |
94 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.91865212 |
95 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.91849184 |
96 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.91823578 |
97 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.89241555 |
98 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.86560669 |
99 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.86470754 |
100 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.85927304 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0004147_increased_porphyrin_level | 4.95733607 |
2 | MP0003786_premature_aging | 3.38523363 |
3 | MP0008995_early_reproductive_senescence | 3.36681816 |
4 | MP0009697_abnormal_copulation | 3.14837013 |
5 | MP0002132_abnormal_respiratory_system | 3.01918377 |
6 | MP0008007_abnormal_cellular_replicative | 2.92680487 |
7 | MP0004957_abnormal_blastocyst_morpholog | 2.91243874 |
8 | MP0003718_maternal_effect | 2.74766374 |
9 | MP0006036_abnormal_mitochondrial_physio | 2.61370288 |
10 | MP0004134_abnormal_chest_morphology | 2.49871496 |
11 | MP0003806_abnormal_nucleotide_metabolis | 2.49135109 |
12 | MP0003950_abnormal_plasma_membrane | 2.43909913 |
13 | MP0001542_abnormal_bone_strength | 2.42353173 |
14 | MP0004145_abnormal_muscle_electrophysio | 2.12826240 |
15 | MP0008058_abnormal_DNA_repair | 2.10110497 |
16 | MP0004084_abnormal_cardiac_muscle | 2.08241249 |
17 | MP0000749_muscle_degeneration | 2.07244560 |
18 | MP0008932_abnormal_embryonic_tissue | 2.04939731 |
19 | MP0010094_abnormal_chromosome_stability | 2.03814481 |
20 | MP0005646_abnormal_pituitary_gland | 2.03049331 |
21 | MP0000678_abnormal_parathyroid_gland | 2.01350079 |
22 | MP0006035_abnormal_mitochondrial_morpho | 1.99827134 |
23 | MP0005275_abnormal_skin_tensile | 1.93193656 |
24 | MP0003111_abnormal_nucleus_morphology | 1.89547020 |
25 | MP0005360_urolithiasis | 1.87931383 |
26 | MP0009780_abnormal_chondrocyte_physiolo | 1.83931654 |
27 | MP0003186_abnormal_redox_activity | 1.83491545 |
28 | MP0005503_abnormal_tendon_morphology | 1.75896303 |
29 | MP0003656_abnormal_erythrocyte_physiolo | 1.75527862 |
30 | MP0008775_abnormal_heart_ventricle | 1.75261849 |
31 | MP0000681_abnormal_thyroid_gland | 1.75036456 |
32 | MP0002837_dystrophic_cardiac_calcinosis | 1.61592764 |
33 | MP0005464_abnormal_platelet_physiology | 1.60828104 |
34 | MP0008438_abnormal_cutaneous_collagen | 1.57796049 |
35 | MP0002876_abnormal_thyroid_physiology | 1.56988746 |
36 | MP0006292_abnormal_olfactory_placode | 1.55876541 |
37 | MP0010307_abnormal_tumor_latency | 1.50311282 |
38 | MP0000372_irregular_coat_pigmentation | 1.35416063 |
39 | MP0002396_abnormal_hematopoietic_system | 1.34835156 |
40 | MP0005083_abnormal_biliary_tract | 1.34414941 |
41 | MP0002736_abnormal_nociception_after | 1.33807380 |
42 | MP0004036_abnormal_muscle_relaxation | 1.33072256 |
43 | MP0003195_calcinosis | 1.32307063 |
44 | MP0005389_reproductive_system_phenotype | 1.31208480 |
45 | MP0002210_abnormal_sex_determination | 1.28304875 |
46 | MP0002160_abnormal_reproductive_system | 1.20086052 |
47 | MP0001929_abnormal_gametogenesis | 1.18678825 |
48 | MP0005171_absent_coat_pigmentation | 1.15372291 |
49 | MP0003077_abnormal_cell_cycle | 1.15026745 |
50 | MP0002138_abnormal_hepatobiliary_system | 1.11165270 |
51 | MP0003137_abnormal_impulse_conducting | 1.10243797 |
52 | MP0002102_abnormal_ear_morphology | 1.07123842 |
53 | MP0000358_abnormal_cell_content/ | 1.07067788 |
54 | MP0001661_extended_life_span | 1.06500057 |
55 | MP0005410_abnormal_fertilization | 1.06458999 |
56 | MP0003693_abnormal_embryo_hatching | 1.06228359 |
57 | MP0005332_abnormal_amino_acid | 1.04448741 |
58 | MP0000653_abnormal_sex_gland | 1.04267700 |
59 | MP0000465_gastrointestinal_hemorrhage | 1.02896119 |
60 | MP0001881_abnormal_mammary_gland | 0.98713992 |
61 | MP0008057_abnormal_DNA_replication | 0.97239600 |
62 | MP0000230_abnormal_systemic_arterial | 0.96110020 |
63 | MP0005397_hematopoietic_system_phenotyp | 0.95981066 |
64 | MP0001545_abnormal_hematopoietic_system | 0.95981066 |
65 | MP0008872_abnormal_physiological_respon | 0.95517165 |
66 | MP0003646_muscle_fatigue | 0.94412713 |
67 | MP0005451_abnormal_body_composition | 0.92163284 |
68 | MP0004215_abnormal_myocardial_fiber | 0.90803436 |
69 | MP0001697_abnormal_embryo_size | 0.90106736 |
70 | MP0001919_abnormal_reproductive_system | 0.89737427 |
71 | MP0000350_abnormal_cell_proliferation | 0.86373958 |
72 | MP0004808_abnormal_hematopoietic_stem | 0.85178364 |
73 | MP0001119_abnormal_female_reproductive | 0.84972900 |
74 | MP0005395_other_phenotype | 0.84891003 |
75 | MP0005535_abnormal_body_temperature | 0.83467001 |
76 | MP0002139_abnormal_hepatobiliary_system | 0.83135454 |
77 | MP0003698_abnormal_male_reproductive | 0.82906366 |
78 | MP0001145_abnormal_male_reproductive | 0.82890311 |
79 | MP0006072_abnormal_retinal_apoptosis | 0.82693905 |
80 | MP0005636_abnormal_mineral_homeostasis | 0.82249275 |
81 | MP0001243_abnormal_dermal_layer | 0.81187039 |
82 | MP0002019_abnormal_tumor_incidence | 0.79897704 |
83 | MP0001730_embryonic_growth_arrest | 0.79751912 |
84 | MP0001764_abnormal_homeostasis | 0.79102295 |
85 | MP0000313_abnormal_cell_death | 0.75749600 |
86 | MP0009643_abnormal_urine_homeostasis | 0.73500747 |
87 | MP0000747_muscle_weakness | 0.72768491 |
88 | MP0002080_prenatal_lethality | 0.72045000 |
89 | MP0001485_abnormal_pinna_reflex | 0.71901720 |
90 | MP0005385_cardiovascular_system_phenoty | 0.71700237 |
91 | MP0001544_abnormal_cardiovascular_syste | 0.71700237 |
92 | MP0003942_abnormal_urinary_system | 0.71203713 |
93 | MP0003959_abnormal_lean_body | 0.69780458 |
94 | MP0004883_abnormal_blood_vessel | 0.68624831 |
95 | MP0008789_abnormal_olfactory_epithelium | 0.67538347 |
96 | MP0001968_abnormal_touch/_nociception | 0.67016128 |
97 | MP0000703_abnormal_thymus_morphology | 0.65493773 |
98 | MP0002234_abnormal_pharynx_morphology | 0.63509545 |
99 | MP0001756_abnormal_urination | 0.61029290 |
100 | MP0002161_abnormal_fertility/fecundity | 0.60738190 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Hyperthyroidism (HP:0000836) | 6.09180560 |
2 | Abnormal gallbladder physiology (HP:0012438) | 5.68928770 |
3 | Cholecystitis (HP:0001082) | 5.68928770 |
4 | Truncus arteriosus (HP:0001660) | 5.29730185 |
5 | Hyperglycinemia (HP:0002154) | 4.64246502 |
6 | Hyperglycinuria (HP:0003108) | 4.19877883 |
7 | Acute encephalopathy (HP:0006846) | 3.99252507 |
8 | Hypertensive crisis (HP:0100735) | 3.98719757 |
9 | Limb hypertonia (HP:0002509) | 3.91270076 |
10 | Polycythemia (HP:0001901) | 3.82259054 |
11 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.63109821 |
12 | Termporal pattern (HP:0011008) | 3.53479814 |
13 | Insidious onset (HP:0003587) | 3.53479814 |
14 | Chromsome breakage (HP:0040012) | 3.46903046 |
15 | Prolonged bleeding time (HP:0003010) | 3.46784961 |
16 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.43451350 |
17 | Increased serum pyruvate (HP:0003542) | 3.36212954 |
18 | Abnormality of glycolysis (HP:0004366) | 3.21142832 |
19 | Abnormal hemoglobin (HP:0011902) | 3.12307808 |
20 | Abnormality of the tricuspid valve (HP:0001702) | 3.09166907 |
21 | Seborrheic dermatitis (HP:0001051) | 3.07591517 |
22 | Reticulocytosis (HP:0001923) | 3.07577149 |
23 | Ankyloglossia (HP:0010296) | 3.02849870 |
24 | Spinal muscular atrophy (HP:0007269) | 3.02260048 |
25 | Cholelithiasis (HP:0001081) | 3.01469799 |
26 | Menorrhagia (HP:0000132) | 2.97523091 |
27 | Redundant skin (HP:0001582) | 2.97206910 |
28 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.88855303 |
29 | Metaphyseal dysplasia (HP:0100255) | 2.87902356 |
30 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.86972108 |
31 | Abnormality of glycine metabolism (HP:0010895) | 2.86972108 |
32 | Hyperammonemia (HP:0001987) | 2.86613885 |
33 | Abnormal platelet function (HP:0011869) | 2.81680864 |
34 | Impaired platelet aggregation (HP:0003540) | 2.81680864 |
35 | Abnormal large intestine physiology (HP:0012700) | 2.79518985 |
36 | Duplicated collecting system (HP:0000081) | 2.78860310 |
37 | Bowel incontinence (HP:0002607) | 2.76808019 |
38 | Poikilocytosis (HP:0004447) | 2.75165785 |
39 | Poor head control (HP:0002421) | 2.71280513 |
40 | Acute myeloid leukemia (HP:0004808) | 2.70671028 |
41 | Abnormal gallbladder morphology (HP:0012437) | 2.61963175 |
42 | Pancytopenia (HP:0001876) | 2.61960589 |
43 | Abnormality of reticulocytes (HP:0004312) | 2.60049071 |
44 | Upper limb muscle weakness (HP:0003484) | 2.59912612 |
45 | Male infertility (HP:0003251) | 2.56689768 |
46 | Abnormality of the anterior horn cell (HP:0006802) | 2.54554181 |
47 | Degeneration of anterior horn cells (HP:0002398) | 2.54554181 |
48 | Abnormality of the renal collecting system (HP:0004742) | 2.51544380 |
49 | Long clavicles (HP:0000890) | 2.47801408 |
50 | Venous insufficiency (HP:0005293) | 2.46840147 |
51 | Atelectasis (HP:0100750) | 2.45814914 |
52 | Hepatocellular carcinoma (HP:0001402) | 2.44893556 |
53 | Aplastic anemia (HP:0001915) | 2.43337925 |
54 | Short tibia (HP:0005736) | 2.43094300 |
55 | Abnormal lung lobation (HP:0002101) | 2.43001787 |
56 | Ileus (HP:0002595) | 2.42982649 |
57 | Genetic anticipation (HP:0003743) | 2.42967264 |
58 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.35822546 |
59 | Hepatocellular necrosis (HP:0001404) | 2.34340813 |
60 | Abnormality of oral frenula (HP:0000190) | 2.34007687 |
61 | Cerebral edema (HP:0002181) | 2.33347523 |
62 | Abnormality of serum amino acid levels (HP:0003112) | 2.29323820 |
63 | Myelodysplasia (HP:0002863) | 2.29114282 |
64 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.26404909 |
65 | Submucous cleft hard palate (HP:0000176) | 2.25441500 |
66 | Supernumerary spleens (HP:0009799) | 2.24453553 |
67 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.24195293 |
68 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.24195293 |
69 | Hepatic necrosis (HP:0002605) | 2.20183152 |
70 | Cerebral palsy (HP:0100021) | 2.15425699 |
71 | Abnormality of the corticospinal tract (HP:0002492) | 2.11214609 |
72 | Increased CSF lactate (HP:0002490) | 2.10331302 |
73 | Cerebral hemorrhage (HP:0001342) | 2.09533784 |
74 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.07010538 |
75 | Abnormality of DNA repair (HP:0003254) | 2.05002994 |
76 | Back pain (HP:0003418) | 2.04437442 |
77 | Flat cornea (HP:0007720) | 2.01875552 |
78 | Acute necrotizing encephalopathy (HP:0006965) | 2.01369743 |
79 | Tinnitus (HP:0000360) | 2.00632084 |
80 | Acanthocytosis (HP:0001927) | 1.96130100 |
81 | Mitochondrial inheritance (HP:0001427) | 1.93406984 |
82 | Abnormality of the gallbladder (HP:0005264) | 1.93086275 |
83 | Venous abnormality (HP:0002624) | 1.92867268 |
84 | Median cleft lip (HP:0000161) | 1.92471405 |
85 | Short middle phalanx of the 5th finger (HP:0004220) | 1.92366218 |
86 | Hyperbilirubinemia (HP:0002904) | 1.92292563 |
87 | Secondary amenorrhea (HP:0000869) | 1.90920971 |
88 | Duodenal stenosis (HP:0100867) | 1.90708918 |
89 | Small intestinal stenosis (HP:0012848) | 1.90708918 |
90 | Increased mean platelet volume (HP:0011877) | 1.86819361 |
91 | Abnormality of the pons (HP:0007361) | 1.86294704 |
92 | Increased serum lactate (HP:0002151) | 1.84913522 |
93 | Hypoparathyroidism (HP:0000829) | 1.84459618 |
94 | Esophageal neoplasm (HP:0100751) | 1.84203432 |
95 | Neoplasm of head and neck (HP:0012288) | 1.84203432 |
96 | Small hand (HP:0200055) | 1.84004965 |
97 | Abnormally folded helix (HP:0008544) | 1.83591725 |
98 | Abnormality of the costochondral junction (HP:0000919) | 1.83479434 |
99 | Nausea (HP:0002018) | 1.83472741 |
100 | Nonimmune hydrops fetalis (HP:0001790) | 1.83214686 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EIF2AK1 | 6.62389360 |
2 | EIF2AK3 | 5.18958556 |
3 | STK39 | 4.05193967 |
4 | MKNK2 | 3.88491270 |
5 | BUB1 | 3.69461612 |
6 | ACVR1B | 3.59113472 |
7 | RIPK4 | 3.33623058 |
8 | OXSR1 | 2.77402987 |
9 | MKNK1 | 2.60498564 |
10 | NEK1 | 2.53914217 |
11 | RAF1 | 2.08656928 |
12 | PLK4 | 2.06534726 |
13 | BMPR2 | 2.06314727 |
14 | PLK2 | 1.98945240 |
15 | STK16 | 1.86117590 |
16 | CLK1 | 1.65317580 |
17 | WEE1 | 1.56593794 |
18 | MAP3K2 | 1.47020549 |
19 | EIF2AK2 | 1.45370491 |
20 | NTRK3 | 1.44941270 |
21 | KSR2 | 1.43195973 |
22 | WNK4 | 1.41697449 |
23 | MST4 | 1.41587025 |
24 | NME1 | 1.36339305 |
25 | TTK | 1.21287139 |
26 | CDC7 | 1.18825942 |
27 | STK3 | 1.12608060 |
28 | BCR | 1.10342402 |
29 | PLK3 | 1.03703659 |
30 | TESK2 | 0.99752544 |
31 | MAP3K8 | 0.94613499 |
32 | NUAK1 | 0.94568861 |
33 | ILK | 0.94468813 |
34 | MAP2K1 | 0.90340338 |
35 | BMX | 0.85277413 |
36 | TLK1 | 0.84720717 |
37 | TSSK6 | 0.84437925 |
38 | EEF2K | 0.83409576 |
39 | TEC | 0.79985746 |
40 | CCNB1 | 0.77456283 |
41 | MAPKAPK3 | 0.74348759 |
42 | MYLK | 0.74309220 |
43 | PAK1 | 0.71514889 |
44 | WNK1 | 0.70573930 |
45 | RPS6KA5 | 0.69983668 |
46 | KSR1 | 0.69909654 |
47 | BRSK2 | 0.68139386 |
48 | PAK4 | 0.66178666 |
49 | ERBB3 | 0.64502328 |
50 | NEK2 | 0.63942415 |
51 | KDR | 0.63792715 |
52 | TRPM7 | 0.63671009 |
53 | PHKG2 | 0.62366276 |
54 | PHKG1 | 0.62366276 |
55 | RPS6KA4 | 0.61268763 |
56 | DMPK | 0.59054000 |
57 | MINK1 | 0.56603055 |
58 | BRD4 | 0.53503338 |
59 | PIK3CG | 0.51740445 |
60 | ROCK1 | 0.46270503 |
61 | CSNK2A1 | 0.46240524 |
62 | PLK1 | 0.44149010 |
63 | MAPKAPK5 | 0.43814512 |
64 | CSNK2A2 | 0.42168459 |
65 | CHEK1 | 0.42139151 |
66 | MUSK | 0.41649214 |
67 | ATM | 0.41551787 |
68 | ALK | 0.40873656 |
69 | BTK | 0.36141682 |
70 | IRAK3 | 0.35955715 |
71 | CHEK2 | 0.35442102 |
72 | CDK1 | 0.34777972 |
73 | CSNK1E | 0.34019734 |
74 | PIM2 | 0.33835414 |
75 | ATR | 0.33062156 |
76 | CDK2 | 0.32043359 |
77 | GRK5 | 0.31997018 |
78 | LRRK2 | 0.31554183 |
79 | MAP2K2 | 0.31321334 |
80 | SCYL2 | 0.30688591 |
81 | PTK2B | 0.30557229 |
82 | PIM1 | 0.29765257 |
83 | MAP3K12 | 0.29258861 |
84 | INSRR | 0.28883249 |
85 | PDK2 | 0.26975340 |
86 | CDK8 | 0.24866268 |
87 | JAK2 | 0.24406424 |
88 | TYRO3 | 0.24367258 |
89 | RET | 0.23166749 |
90 | IRAK1 | 0.22492711 |
91 | AURKB | 0.21623511 |
92 | DYRK3 | 0.21574792 |
93 | ADRBK2 | 0.20346600 |
94 | PTK6 | 0.20200392 |
95 | SRPK1 | 0.20176982 |
96 | STK4 | 0.20165333 |
97 | PRKACG | 0.20047903 |
98 | GRK7 | 0.18785995 |
99 | TAOK3 | 0.18596648 |
100 | PAK2 | 0.18585444 |
Rank | Gene Set | Z-score |
---|---|---|
1 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.77146410 |
2 | Proteasome_Homo sapiens_hsa03050 | 3.59082435 |
3 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 3.56910756 |
4 | Sulfur metabolism_Homo sapiens_hsa00920 | 3.40224938 |
5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.30524418 |
6 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.27302617 |
7 | RNA transport_Homo sapiens_hsa03013 | 3.24045118 |
8 | DNA replication_Homo sapiens_hsa03030 | 2.99461187 |
9 | Mismatch repair_Homo sapiens_hsa03430 | 2.90924837 |
10 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 2.75758130 |
11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.73566729 |
12 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.20698102 |
13 | Spliceosome_Homo sapiens_hsa03040 | 2.18560781 |
14 | Basal transcription factors_Homo sapiens_hsa03022 | 2.17721012 |
15 | Parkinsons disease_Homo sapiens_hsa05012 | 1.98616907 |
16 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.91211618 |
17 | Homologous recombination_Homo sapiens_hsa03440 | 1.77708375 |
18 | RNA degradation_Homo sapiens_hsa03018 | 1.68504189 |
19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.67424796 |
20 | RNA polymerase_Homo sapiens_hsa03020 | 1.63533063 |
21 | Carbon metabolism_Homo sapiens_hsa01200 | 1.60839375 |
22 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.50552162 |
23 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.49601351 |
24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.48415936 |
25 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.44024789 |
26 | Protein export_Homo sapiens_hsa03060 | 1.41389521 |
27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35963169 |
28 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.35754159 |
29 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.34591048 |
30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.29863724 |
31 | Cell cycle_Homo sapiens_hsa04110 | 1.27310027 |
32 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.24671104 |
33 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.21118113 |
34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.16443952 |
35 | Olfactory transduction_Homo sapiens_hsa04740 | 1.16196417 |
36 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.02823923 |
37 | Alzheimers disease_Homo sapiens_hsa05010 | 1.00605461 |
38 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.99590647 |
39 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.99171087 |
40 | Purine metabolism_Homo sapiens_hsa00230 | 0.99044794 |
41 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.97224327 |
42 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.94673981 |
43 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.94254427 |
44 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.91173004 |
45 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82526698 |
46 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.79144534 |
47 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.78834835 |
48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.74903465 |
49 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.74103737 |
50 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.72106252 |
51 | Platelet activation_Homo sapiens_hsa04611 | 0.68898121 |
52 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.65890473 |
53 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.65852240 |
54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.62797424 |
55 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62611918 |
56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.58668619 |
57 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.58154257 |
58 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.57722356 |
59 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.57628363 |
60 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.57594346 |
61 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.55869883 |
62 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.53536382 |
63 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52473530 |
64 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.49165567 |
65 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.47218536 |
66 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.47078920 |
67 | Melanoma_Homo sapiens_hsa05218 | 0.47038059 |
68 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.46302332 |
69 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.46027979 |
70 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.45997577 |
71 | Malaria_Homo sapiens_hsa05144 | 0.45714560 |
72 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.44952042 |
73 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41563787 |
74 | Shigellosis_Homo sapiens_hsa05131 | 0.41110320 |
75 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.39546678 |
76 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.38678640 |
77 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.37571180 |
78 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.34295772 |
79 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.33993497 |
80 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.32341471 |
81 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.29821800 |
82 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29148972 |
83 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.29118884 |
84 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.27636760 |
85 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.26818423 |
86 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.25443836 |
87 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.25059848 |
88 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.24638075 |
89 | Phototransduction_Homo sapiens_hsa04744 | 0.23390275 |
90 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.22792225 |
91 | Peroxisome_Homo sapiens_hsa04146 | 0.21735912 |
92 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21097738 |
93 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.20966162 |
94 | Ribosome_Homo sapiens_hsa03010 | 0.20272354 |
95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.20237578 |
96 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.20159169 |
97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.19442845 |
98 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.18150111 |
99 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.17839852 |
100 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.17327921 |