ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cullin deneddylation (GO:0010388)	7.48034681
2	maturation of 5.8S rRNA (GO:0000460)	6.72597076
3	protein deneddylation (GO:0000338)	6.58407477
4	nuclear pore organization (GO:0006999)	6.57904679
5	synapsis (GO:0007129)	6.44211440
6	negative regulation of histone acetylation (GO:0035067)	6.29821416
7	nuclear pore complex assembly (GO:0051292)	6.17059865
8	negative regulation of protein acetylation (GO:1901984)	5.50134132
9	negative regulation of peptidyl-lysine acetylation (GO:2000757)	5.05518919
10	mitotic nuclear envelope disassembly (GO:0007077)	5.04020550
11	regulation of response to osmotic stress (GO:0047484)	4.95734978
12	resolution of meiotic recombination intermediates (GO:0000712)	4.83396437
13	regulation of DNA endoreduplication (GO:0032875)	4.72366911
14	pore complex assembly (GO:0046931)	4.71638320
15	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.59314204
16	deoxyribose phosphate biosynthetic process (GO:0046385)	4.59314204
17	membrane disassembly (GO:0030397)	4.59073080
18	nuclear envelope disassembly (GO:0051081)	4.59073080
19	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.42808156
20	ribosome assembly (GO:0042255)	4.42131685
21	diterpenoid biosynthetic process (GO:0016102)	4.38115310
22	terpenoid biosynthetic process (GO:0016114)	4.32203135
23	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.28541769
24	oxidative phosphorylation (GO:0006119)	4.11705073
25	regulation of translational fidelity (GO:0006450)	4.07625613
26	intra-S DNA damage checkpoint (GO:0031573)	3.91997550
27	DNA replication initiation (GO:0006270)	3.88375371
28	protoporphyrinogen IX metabolic process (GO:0046501)	3.79962331
29	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.79211809
30	DNA replication checkpoint (GO:0000076)	3.76437468
31	folic acid-containing compound biosynthetic process (GO:0009396)	3.70687741
32	biotin metabolic process (GO:0006768)	3.70528374
33	protein-DNA complex disassembly (GO:0032986)	3.61219412
34	nucleosome disassembly (GO:0006337)	3.61219412
35	IMP biosynthetic process (GO:0006188)	3.57152284
36	mitotic sister chromatid segregation (GO:0000070)	3.55941716
37	rRNA catabolic process (GO:0016075)	3.54945798
38	mitochondrial DNA replication (GO:0006264)	3.50430136
39	DNA catabolic process, exonucleolytic (GO:0000738)	3.49000655
40	response to pheromone (GO:0019236)	3.48105318
41	regulation of translational elongation (GO:0006448)	3.47838885
42	proteasome assembly (GO:0043248)	3.46243736
43	IMP metabolic process (GO:0046040)	3.44496109
44	N-terminal protein amino acid acetylation (GO:0006474)	3.38817126
45	rRNA methylation (GO:0031167)	3.33742300
46	deoxyribonucleotide biosynthetic process (GO:0009263)	3.33603871
47	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.32085157
48	microtubule severing (GO:0051013)	3.31510553
49	organelle disassembly (GO:1903008)	3.29188439
50	DNA replication-dependent nucleosome assembly (GO:0006335)	3.29036589
51	DNA replication-dependent nucleosome organization (GO:0034723)	3.29036589
52	DNA unwinding involved in DNA replication (GO:0006268)	3.28716823
53	rRNA modification (GO:0000154)	3.28429634
54	regulation of mitotic spindle organization (GO:0060236)	3.24731028
55	nuclear envelope organization (GO:0006998)	3.24457013
56	sister chromatid segregation (GO:0000819)	3.22500910
57	formation of translation preinitiation complex (GO:0001731)	3.22248609
58	definitive hemopoiesis (GO:0060216)	3.22067956
59	meiotic chromosome segregation (GO:0045132)	3.21056656
60	regulation of B cell apoptotic process (GO:0002902)	3.18755989
61	microtubule depolymerization (GO:0007019)	3.16215028
62	viral mRNA export from host cell nucleus (GO:0046784)	3.15423717
63	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.15138079
64	gas transport (GO:0015669)	3.13574266
65	tetrahydrofolate metabolic process (GO:0046653)	3.08406240
66	attachment of spindle microtubules to kinetochore (GO:0008608)	3.05911291
67	regulation of histone H3-K4 methylation (GO:0051569)	3.04919274
68	oxygen transport (GO:0015671)	3.03965984
69	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	3.02801086
70	protein-cofactor linkage (GO:0018065)	3.01084309
71	lipopolysaccharide biosynthetic process (GO:0009103)	2.99798909
72	embryonic camera-type eye development (GO:0031076)	2.98685014
73	erythrocyte maturation (GO:0043249)	2.93135558
74	DNA methylation involved in gamete generation (GO:0043046)	2.92747401
75	DNA replication-independent nucleosome assembly (GO:0006336)	2.92701972
76	DNA replication-independent nucleosome organization (GO:0034724)	2.92701972
77	CENP-A containing nucleosome assembly (GO:0034080)	2.91101858
78	short-chain fatty acid metabolic process (GO:0046459)	2.89481070
79	mitochondrial DNA metabolic process (GO:0032042)	2.86711482
80	pseudouridine synthesis (GO:0001522)	2.86491689
81	chromosome organization involved in meiosis (GO:0070192)	2.81640346
82	purine nucleobase biosynthetic process (GO:0009113)	2.81490584
83	poly(A)+ mRNA export from nucleus (GO:0016973)	2.79979128
84	GMP metabolic process (GO:0046037)	2.78256401
85	nucleobase biosynthetic process (GO:0046112)	2.76421302
86	nucleotide-sugar biosynthetic process (GO:0009226)	2.74648938
87	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.72743393
88	negative regulation of erythrocyte differentiation (GO:0045647)	2.72255131
89	organelle membrane fusion (GO:0090174)	2.69050576
90	erythrocyte development (GO:0048821)	2.68754421
91	chromatin remodeling at centromere (GO:0031055)	2.66812716
92	protein neddylation (GO:0045116)	2.66032916
93	transcription from mitochondrial promoter (GO:0006390)	2.65904170
94	histone exchange (GO:0043486)	2.63892985
95	mRNA cleavage (GO:0006379)	2.62906193
96	valine metabolic process (GO:0006573)	2.61589783
97	regulation of DNA-dependent DNA replication (GO:0090329)	2.61528519
98	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.60869739
99	inner mitochondrial membrane organization (GO:0007007)	2.58062177
100	phagocytosis, recognition (GO:0006910)	2.57584176

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.68374570
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.77315031
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.32248212
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.19906266
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.00978973
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.97562566
7	ELK1_19687146_ChIP-ChIP_HELA_Human	2.93720046
8	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.88766362
9	NCOR1_26117541_ChIP-Seq_K562_Human	2.82345294
10	GATA1_19941826_ChIP-Seq_K562_Human	2.77236018
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.76333665
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.74055812
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.71463695
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.63491128
15	CIITA_25753668_ChIP-Seq_RAJI_Human	2.60409446
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.42084047
17	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.40126076
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34461246
19	VDR_22108803_ChIP-Seq_LS180_Human	2.32218668
20	AR_21909140_ChIP-Seq_LNCAP_Human	2.27495934
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.27289796
22	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.22513414
23	VDR_23849224_ChIP-Seq_CD4+_Human	2.01837048
24	GATA2_19941826_ChIP-Seq_K562_Human	2.00130406
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.92942827
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.88775109
27	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.84172277
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.83228932
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.80286072
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.79099975
31	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.72019494
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71815433
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.71602634
34	ZNF263_19887448_ChIP-Seq_K562_Human	1.68869241
35	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.63981066
36	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.62981450
37	GATA1_22025678_ChIP-Seq_K562_Human	1.61591511
38	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.59806377
39	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.58845195
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.58589576
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.58556205
42	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.55195735
43	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.54343777
44	DCP1A_22483619_ChIP-Seq_HELA_Human	1.53840498
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.52988016
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50927602
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50771365
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.50329107
49	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.50066811
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.49802266
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46750853
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46527726
53	PHF8_20622853_ChIP-Seq_HELA_Human	1.46431279
54	RBPJ_21746931_ChIP-Seq_IB4_Human	1.45432949
55	GABP_19822575_ChIP-Seq_HepG2_Human	1.45415693
56	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.45251725
57	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.41422974
58	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40810952
59	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.40105830
60	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.38582163
61	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.37796856
62	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.37124832
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36962433
64	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.35469740
65	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.29420037
66	ETS1_22383799_ChIP-Seq_G1ME_Mouse	1.28534151
67	ETV1_20927104_ChIP-Seq_GIST48_Human	1.28470383
68	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24127225
69	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.19668924
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.17716274
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16437144
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.12474630
73	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11878179
74	NFYA_21822215_ChIP-Seq_K562_Human	1.11661005
75	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11465065
76	SPI1_23127762_ChIP-Seq_K562_Human	1.08739557
77	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.08210383
78	EWS_26573619_Chip-Seq_HEK293_Human	1.05481587
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04911620
80	NFYB_21822215_ChIP-Seq_K562_Human	1.04416836
81	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.02313128
82	SCL_19346495_ChIP-Seq_HPC-7_Human	1.02100608
83	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.00939897
84	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.00174061
85	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.99609343
86	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.98825140
87	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.97449533
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96664857
89	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.96533826
90	ELF5_23300383_ChIP-Seq_T47D_Human	0.94358736
91	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.94070560
92	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93180740
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92879763
94	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.91865212
95	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.91849184
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91823578
97	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89241555
98	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.86560669
99	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.86470754
100	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.85927304

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.95733607
2	MP0003786_premature_aging	3.38523363
3	MP0008995_early_reproductive_senescence	3.36681816
4	MP0009697_abnormal_copulation	3.14837013
5	MP0002132_abnormal_respiratory_system	3.01918377
6	MP0008007_abnormal_cellular_replicative	2.92680487
7	MP0004957_abnormal_blastocyst_morpholog	2.91243874
8	MP0003718_maternal_effect	2.74766374
9	MP0006036_abnormal_mitochondrial_physio	2.61370288
10	MP0004134_abnormal_chest_morphology	2.49871496
11	MP0003806_abnormal_nucleotide_metabolis	2.49135109
12	MP0003950_abnormal_plasma_membrane	2.43909913
13	MP0001542_abnormal_bone_strength	2.42353173
14	MP0004145_abnormal_muscle_electrophysio	2.12826240
15	MP0008058_abnormal_DNA_repair	2.10110497
16	MP0004084_abnormal_cardiac_muscle	2.08241249
17	MP0000749_muscle_degeneration	2.07244560
18	MP0008932_abnormal_embryonic_tissue	2.04939731
19	MP0010094_abnormal_chromosome_stability	2.03814481
20	MP0005646_abnormal_pituitary_gland	2.03049331
21	MP0000678_abnormal_parathyroid_gland	2.01350079
22	MP0006035_abnormal_mitochondrial_morpho	1.99827134
23	MP0005275_abnormal_skin_tensile	1.93193656
24	MP0003111_abnormal_nucleus_morphology	1.89547020
25	MP0005360_urolithiasis	1.87931383
26	MP0009780_abnormal_chondrocyte_physiolo	1.83931654
27	MP0003186_abnormal_redox_activity	1.83491545
28	MP0005503_abnormal_tendon_morphology	1.75896303
29	MP0003656_abnormal_erythrocyte_physiolo	1.75527862
30	MP0008775_abnormal_heart_ventricle	1.75261849
31	MP0000681_abnormal_thyroid_gland	1.75036456
32	MP0002837_dystrophic_cardiac_calcinosis	1.61592764
33	MP0005464_abnormal_platelet_physiology	1.60828104
34	MP0008438_abnormal_cutaneous_collagen	1.57796049
35	MP0002876_abnormal_thyroid_physiology	1.56988746
36	MP0006292_abnormal_olfactory_placode	1.55876541
37	MP0010307_abnormal_tumor_latency	1.50311282
38	MP0000372_irregular_coat_pigmentation	1.35416063
39	MP0002396_abnormal_hematopoietic_system	1.34835156
40	MP0005083_abnormal_biliary_tract	1.34414941
41	MP0002736_abnormal_nociception_after	1.33807380
42	MP0004036_abnormal_muscle_relaxation	1.33072256
43	MP0003195_calcinosis	1.32307063
44	MP0005389_reproductive_system_phenotype	1.31208480
45	MP0002210_abnormal_sex_determination	1.28304875
46	MP0002160_abnormal_reproductive_system	1.20086052
47	MP0001929_abnormal_gametogenesis	1.18678825
48	MP0005171_absent_coat_pigmentation	1.15372291
49	MP0003077_abnormal_cell_cycle	1.15026745
50	MP0002138_abnormal_hepatobiliary_system	1.11165270
51	MP0003137_abnormal_impulse_conducting	1.10243797
52	MP0002102_abnormal_ear_morphology	1.07123842
53	MP0000358_abnormal_cell_content/	1.07067788
54	MP0001661_extended_life_span	1.06500057
55	MP0005410_abnormal_fertilization	1.06458999
56	MP0003693_abnormal_embryo_hatching	1.06228359
57	MP0005332_abnormal_amino_acid	1.04448741
58	MP0000653_abnormal_sex_gland	1.04267700
59	MP0000465_gastrointestinal_hemorrhage	1.02896119
60	MP0001881_abnormal_mammary_gland	0.98713992
61	MP0008057_abnormal_DNA_replication	0.97239600
62	MP0000230_abnormal_systemic_arterial	0.96110020
63	MP0005397_hematopoietic_system_phenotyp	0.95981066
64	MP0001545_abnormal_hematopoietic_system	0.95981066
65	MP0008872_abnormal_physiological_respon	0.95517165
66	MP0003646_muscle_fatigue	0.94412713
67	MP0005451_abnormal_body_composition	0.92163284
68	MP0004215_abnormal_myocardial_fiber	0.90803436
69	MP0001697_abnormal_embryo_size	0.90106736
70	MP0001919_abnormal_reproductive_system	0.89737427
71	MP0000350_abnormal_cell_proliferation	0.86373958
72	MP0004808_abnormal_hematopoietic_stem	0.85178364
73	MP0001119_abnormal_female_reproductive	0.84972900
74	MP0005395_other_phenotype	0.84891003
75	MP0005535_abnormal_body_temperature	0.83467001
76	MP0002139_abnormal_hepatobiliary_system	0.83135454
77	MP0003698_abnormal_male_reproductive	0.82906366
78	MP0001145_abnormal_male_reproductive	0.82890311
79	MP0006072_abnormal_retinal_apoptosis	0.82693905
80	MP0005636_abnormal_mineral_homeostasis	0.82249275
81	MP0001243_abnormal_dermal_layer	0.81187039
82	MP0002019_abnormal_tumor_incidence	0.79897704
83	MP0001730_embryonic_growth_arrest	0.79751912
84	MP0001764_abnormal_homeostasis	0.79102295
85	MP0000313_abnormal_cell_death	0.75749600
86	MP0009643_abnormal_urine_homeostasis	0.73500747
87	MP0000747_muscle_weakness	0.72768491
88	MP0002080_prenatal_lethality	0.72045000
89	MP0001485_abnormal_pinna_reflex	0.71901720
90	MP0005385_cardiovascular_system_phenoty	0.71700237
91	MP0001544_abnormal_cardiovascular_syste	0.71700237
92	MP0003942_abnormal_urinary_system	0.71203713
93	MP0003959_abnormal_lean_body	0.69780458
94	MP0004883_abnormal_blood_vessel	0.68624831
95	MP0008789_abnormal_olfactory_epithelium	0.67538347
96	MP0001968_abnormal_touch/_nociception	0.67016128
97	MP0000703_abnormal_thymus_morphology	0.65493773
98	MP0002234_abnormal_pharynx_morphology	0.63509545
99	MP0001756_abnormal_urination	0.61029290
100	MP0002161_abnormal_fertility/fecundity	0.60738190

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperthyroidism (HP:0000836)	6.09180560
2	Abnormal gallbladder physiology (HP:0012438)	5.68928770
3	Cholecystitis (HP:0001082)	5.68928770
4	Truncus arteriosus (HP:0001660)	5.29730185
5	Hyperglycinemia (HP:0002154)	4.64246502
6	Hyperglycinuria (HP:0003108)	4.19877883
7	Acute encephalopathy (HP:0006846)	3.99252507
8	Hypertensive crisis (HP:0100735)	3.98719757
9	Limb hypertonia (HP:0002509)	3.91270076
10	Polycythemia (HP:0001901)	3.82259054
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.63109821
12	Termporal pattern (HP:0011008)	3.53479814
13	Insidious onset (HP:0003587)	3.53479814
14	Chromsome breakage (HP:0040012)	3.46903046
15	Prolonged bleeding time (HP:0003010)	3.46784961
16	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.43451350
17	Increased serum pyruvate (HP:0003542)	3.36212954
18	Abnormality of glycolysis (HP:0004366)	3.21142832
19	Abnormal hemoglobin (HP:0011902)	3.12307808
20	Abnormality of the tricuspid valve (HP:0001702)	3.09166907
21	Seborrheic dermatitis (HP:0001051)	3.07591517
22	Reticulocytosis (HP:0001923)	3.07577149
23	Ankyloglossia (HP:0010296)	3.02849870
24	Spinal muscular atrophy (HP:0007269)	3.02260048
25	Cholelithiasis (HP:0001081)	3.01469799
26	Menorrhagia (HP:0000132)	2.97523091
27	Redundant skin (HP:0001582)	2.97206910
28	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.88855303
29	Metaphyseal dysplasia (HP:0100255)	2.87902356
30	Abnormality of serine family amino acid metabolism (HP:0010894)	2.86972108
31	Abnormality of glycine metabolism (HP:0010895)	2.86972108
32	Hyperammonemia (HP:0001987)	2.86613885
33	Abnormal platelet function (HP:0011869)	2.81680864
34	Impaired platelet aggregation (HP:0003540)	2.81680864
35	Abnormal large intestine physiology (HP:0012700)	2.79518985
36	Duplicated collecting system (HP:0000081)	2.78860310
37	Bowel incontinence (HP:0002607)	2.76808019
38	Poikilocytosis (HP:0004447)	2.75165785
39	Poor head control (HP:0002421)	2.71280513
40	Acute myeloid leukemia (HP:0004808)	2.70671028
41	Abnormal gallbladder morphology (HP:0012437)	2.61963175
42	Pancytopenia (HP:0001876)	2.61960589
43	Abnormality of reticulocytes (HP:0004312)	2.60049071
44	Upper limb muscle weakness (HP:0003484)	2.59912612
45	Male infertility (HP:0003251)	2.56689768
46	Abnormality of the anterior horn cell (HP:0006802)	2.54554181
47	Degeneration of anterior horn cells (HP:0002398)	2.54554181
48	Abnormality of the renal collecting system (HP:0004742)	2.51544380
49	Long clavicles (HP:0000890)	2.47801408
50	Venous insufficiency (HP:0005293)	2.46840147
51	Atelectasis (HP:0100750)	2.45814914
52	Hepatocellular carcinoma (HP:0001402)	2.44893556
53	Aplastic anemia (HP:0001915)	2.43337925
54	Short tibia (HP:0005736)	2.43094300
55	Abnormal lung lobation (HP:0002101)	2.43001787
56	Ileus (HP:0002595)	2.42982649
57	Genetic anticipation (HP:0003743)	2.42967264
58	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.35822546
59	Hepatocellular necrosis (HP:0001404)	2.34340813
60	Abnormality of oral frenula (HP:0000190)	2.34007687
61	Cerebral edema (HP:0002181)	2.33347523
62	Abnormality of serum amino acid levels (HP:0003112)	2.29323820
63	Myelodysplasia (HP:0002863)	2.29114282
64	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.26404909
65	Submucous cleft hard palate (HP:0000176)	2.25441500
66	Supernumerary spleens (HP:0009799)	2.24453553
67	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.24195293
68	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.24195293
69	Hepatic necrosis (HP:0002605)	2.20183152
70	Cerebral palsy (HP:0100021)	2.15425699
71	Abnormality of the corticospinal tract (HP:0002492)	2.11214609
72	Increased CSF lactate (HP:0002490)	2.10331302
73	Cerebral hemorrhage (HP:0001342)	2.09533784
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07010538
75	Abnormality of DNA repair (HP:0003254)	2.05002994
76	Back pain (HP:0003418)	2.04437442
77	Flat cornea (HP:0007720)	2.01875552
78	Acute necrotizing encephalopathy (HP:0006965)	2.01369743
79	Tinnitus (HP:0000360)	2.00632084
80	Acanthocytosis (HP:0001927)	1.96130100
81	Mitochondrial inheritance (HP:0001427)	1.93406984
82	Abnormality of the gallbladder (HP:0005264)	1.93086275
83	Venous abnormality (HP:0002624)	1.92867268
84	Median cleft lip (HP:0000161)	1.92471405
85	Short middle phalanx of the 5th finger (HP:0004220)	1.92366218
86	Hyperbilirubinemia (HP:0002904)	1.92292563
87	Secondary amenorrhea (HP:0000869)	1.90920971
88	Duodenal stenosis (HP:0100867)	1.90708918
89	Small intestinal stenosis (HP:0012848)	1.90708918
90	Increased mean platelet volume (HP:0011877)	1.86819361
91	Abnormality of the pons (HP:0007361)	1.86294704
92	Increased serum lactate (HP:0002151)	1.84913522
93	Hypoparathyroidism (HP:0000829)	1.84459618
94	Esophageal neoplasm (HP:0100751)	1.84203432
95	Neoplasm of head and neck (HP:0012288)	1.84203432
96	Small hand (HP:0200055)	1.84004965
97	Abnormally folded helix (HP:0008544)	1.83591725
98	Abnormality of the costochondral junction (HP:0000919)	1.83479434
99	Nausea (HP:0002018)	1.83472741
100	Nonimmune hydrops fetalis (HP:0001790)	1.83214686

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	6.62389360
2	EIF2AK3	5.18958556
3	STK39	4.05193967
4	MKNK2	3.88491270
5	BUB1	3.69461612
6	ACVR1B	3.59113472
7	RIPK4	3.33623058
8	OXSR1	2.77402987
9	MKNK1	2.60498564
10	NEK1	2.53914217
11	RAF1	2.08656928
12	PLK4	2.06534726
13	BMPR2	2.06314727
14	PLK2	1.98945240
15	STK16	1.86117590
16	CLK1	1.65317580
17	WEE1	1.56593794
18	MAP3K2	1.47020549
19	EIF2AK2	1.45370491
20	NTRK3	1.44941270
21	KSR2	1.43195973
22	WNK4	1.41697449
23	MST4	1.41587025
24	NME1	1.36339305
25	TTK	1.21287139
26	CDC7	1.18825942
27	STK3	1.12608060
28	BCR	1.10342402
29	PLK3	1.03703659
30	TESK2	0.99752544
31	MAP3K8	0.94613499
32	NUAK1	0.94568861
33	ILK	0.94468813
34	MAP2K1	0.90340338
35	BMX	0.85277413
36	TLK1	0.84720717
37	TSSK6	0.84437925
38	EEF2K	0.83409576
39	TEC	0.79985746
40	CCNB1	0.77456283
41	MAPKAPK3	0.74348759
42	MYLK	0.74309220
43	PAK1	0.71514889
44	WNK1	0.70573930
45	RPS6KA5	0.69983668
46	KSR1	0.69909654
47	BRSK2	0.68139386
48	PAK4	0.66178666
49	ERBB3	0.64502328
50	NEK2	0.63942415
51	KDR	0.63792715
52	TRPM7	0.63671009
53	PHKG2	0.62366276
54	PHKG1	0.62366276
55	RPS6KA4	0.61268763
56	DMPK	0.59054000
57	MINK1	0.56603055
58	BRD4	0.53503338
59	PIK3CG	0.51740445
60	ROCK1	0.46270503
61	CSNK2A1	0.46240524
62	PLK1	0.44149010
63	MAPKAPK5	0.43814512
64	CSNK2A2	0.42168459
65	CHEK1	0.42139151
66	MUSK	0.41649214
67	ATM	0.41551787
68	ALK	0.40873656
69	BTK	0.36141682
70	IRAK3	0.35955715
71	CHEK2	0.35442102
72	CDK1	0.34777972
73	CSNK1E	0.34019734
74	PIM2	0.33835414
75	ATR	0.33062156
76	CDK2	0.32043359
77	GRK5	0.31997018
78	LRRK2	0.31554183
79	MAP2K2	0.31321334
80	SCYL2	0.30688591
81	PTK2B	0.30557229
82	PIM1	0.29765257
83	MAP3K12	0.29258861
84	INSRR	0.28883249
85	PDK2	0.26975340
86	CDK8	0.24866268
87	JAK2	0.24406424
88	TYRO3	0.24367258
89	RET	0.23166749
90	IRAK1	0.22492711
91	AURKB	0.21623511
92	DYRK3	0.21574792
93	ADRBK2	0.20346600
94	PTK6	0.20200392
95	SRPK1	0.20176982
96	STK4	0.20165333
97	PRKACG	0.20047903
98	GRK7	0.18785995
99	TAOK3	0.18596648
100	PAK2	0.18585444

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.77146410
2	Proteasome_Homo sapiens_hsa03050	3.59082435
3	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	3.56910756
4	Sulfur metabolism_Homo sapiens_hsa00920	3.40224938
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.30524418
6	Propanoate metabolism_Homo sapiens_hsa00640	3.27302617
7	RNA transport_Homo sapiens_hsa03013	3.24045118
8	DNA replication_Homo sapiens_hsa03030	2.99461187
9	Mismatch repair_Homo sapiens_hsa03430	2.90924837
10	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.75758130
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.73566729
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.20698102
13	Spliceosome_Homo sapiens_hsa03040	2.18560781
14	Basal transcription factors_Homo sapiens_hsa03022	2.17721012
15	Parkinsons disease_Homo sapiens_hsa05012	1.98616907
16	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.91211618
17	Homologous recombination_Homo sapiens_hsa03440	1.77708375
18	RNA degradation_Homo sapiens_hsa03018	1.68504189
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.67424796
20	RNA polymerase_Homo sapiens_hsa03020	1.63533063
21	Carbon metabolism_Homo sapiens_hsa01200	1.60839375
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50552162
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.49601351
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48415936
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.44024789
26	Protein export_Homo sapiens_hsa03060	1.41389521
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.35963169
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35754159
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.34591048
30	Huntingtons disease_Homo sapiens_hsa05016	1.29863724
31	Cell cycle_Homo sapiens_hsa04110	1.27310027
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24671104
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.21118113
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16443952
35	Olfactory transduction_Homo sapiens_hsa04740	1.16196417
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.02823923
37	Alzheimers disease_Homo sapiens_hsa05010	1.00605461
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.99590647
39	Oocyte meiosis_Homo sapiens_hsa04114	0.99171087
40	Purine metabolism_Homo sapiens_hsa00230	0.99044794
41	Butanoate metabolism_Homo sapiens_hsa00650	0.97224327
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.94673981
43	mTOR signaling pathway_Homo sapiens_hsa04150	0.94254427
44	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.91173004
45	Glutathione metabolism_Homo sapiens_hsa00480	0.82526698
46	Caffeine metabolism_Homo sapiens_hsa00232	0.79144534
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78834835
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74903465
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74103737
50	p53 signaling pathway_Homo sapiens_hsa04115	0.72106252
51	Platelet activation_Homo sapiens_hsa04611	0.68898121
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.65890473
53	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.65852240
54	Metabolic pathways_Homo sapiens_hsa01100	0.62797424
55	Retinol metabolism_Homo sapiens_hsa00830	0.62611918
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58668619
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.58154257
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57722356
59	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.57628363
60	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.57594346
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.55869883
62	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53536382
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52473530
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49165567
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47218536
66	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47078920
67	Melanoma_Homo sapiens_hsa05218	0.47038059
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46302332
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.46027979
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.45997577
71	Malaria_Homo sapiens_hsa05144	0.45714560
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44952042
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41563787
74	Shigellosis_Homo sapiens_hsa05131	0.41110320
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.39546678
76	Viral carcinogenesis_Homo sapiens_hsa05203	0.38678640
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37571180
78	Acute myeloid leukemia_Homo sapiens_hsa05221	0.34295772
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.33993497
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.32341471
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29821800
82	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.29148972
83	Fatty acid elongation_Homo sapiens_hsa00062	0.29118884
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.27636760
85	Herpes simplex infection_Homo sapiens_hsa05168	0.26818423
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.25443836
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.25059848
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.24638075
89	Phototransduction_Homo sapiens_hsa04744	0.23390275
90	Insulin signaling pathway_Homo sapiens_hsa04910	0.22792225
91	Peroxisome_Homo sapiens_hsa04146	0.21735912
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.21097738
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.20966162
94	Ribosome_Homo sapiens_hsa03010	0.20272354
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20237578
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.20159169
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.19442845
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.18150111
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.17839852
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.17327921

HMGN1P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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