ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	translesion synthesis (GO:0019985)	5.79580490
2	interferon-gamma secretion (GO:0072643)	5.74119044
3	replication fork processing (GO:0031297)	5.62754719
4	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	5.58073656
5	cell wall macromolecule catabolic process (GO:0016998)	5.47548399
6	regulation of protein polyubiquitination (GO:1902914)	5.11218631
7	positive regulation of respiratory burst (GO:0060267)	5.10096189
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	5.02138693
9	regulation of translation, ncRNA-mediated (GO:0045974)	5.02138693
10	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	5.02138693
11	proteasome assembly (GO:0043248)	4.90378701
12	lateral sprouting from an epithelium (GO:0060601)	4.86002179
13	cellular response to interleukin-15 (GO:0071350)	4.85602443
14	negative regulation of DNA repair (GO:0045738)	4.75036221
15	nonmotile primary cilium assembly (GO:0035058)	4.71810520
16	postreplication repair (GO:0006301)	4.69069828
17	DNA strand renaturation (GO:0000733)	4.65301054
18	neural tube formation (GO:0001841)	4.64811167
19	cell wall macromolecule metabolic process (GO:0044036)	4.50625415
20	C4-dicarboxylate transport (GO:0015740)	4.19912068
21	DNA damage response, detection of DNA damage (GO:0042769)	4.12709553
22	transcription from mitochondrial promoter (GO:0006390)	4.00331121
23	heparan sulfate proteoglycan metabolic process (GO:0030201)	3.94525983
24	pre-miRNA processing (GO:0031054)	3.92580501
25	regulation of sarcomere organization (GO:0060297)	3.85880940
26	positive regulation of catenin import into nucleus (GO:0035413)	3.84965035
27	fatty acid elongation (GO:0030497)	3.78858278
28	negative regulation of DNA recombination (GO:0045910)	3.78838515
29	lens development in camera-type eye (GO:0002088)	3.76798783
30	lipid particle organization (GO:0034389)	3.76271865
31	limb bud formation (GO:0060174)	3.70022029
32	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.68231873
33	kidney morphogenesis (GO:0060993)	3.61753916
34	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.56497821
35	presynaptic membrane assembly (GO:0097105)	3.43996800
36	serine family amino acid catabolic process (GO:0009071)	3.32467927
37	response to interleukin-15 (GO:0070672)	3.28720712
38	indole-containing compound catabolic process (GO:0042436)	3.20808194
39	indolalkylamine catabolic process (GO:0046218)	3.20808194
40	tryptophan catabolic process (GO:0006569)	3.20808194
41	positive regulation of cell cycle G2/M phase transition (GO:1902751)	3.19733164
42	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	3.19733164
43	intraciliary transport (GO:0042073)	3.18151719
44	reciprocal DNA recombination (GO:0035825)	3.17417519
45	reciprocal meiotic recombination (GO:0007131)	3.17417519
46	positive regulation of DNA repair (GO:0045739)	3.15778077
47	linoleic acid metabolic process (GO:0043651)	3.11896403
48	regulation of penile erection (GO:0060405)	3.11831743
49	retinal cone cell development (GO:0046549)	3.11362425
50	proteoglycan biosynthetic process (GO:0030166)	3.11218595
51	ubiquinone biosynthetic process (GO:0006744)	3.10926626
52	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.09103307
53	peptidyl-histidine modification (GO:0018202)	3.05608623
54	positive regulation of glycolytic process (GO:0045821)	3.05157269
55	positive regulation of gastrulation (GO:2000543)	3.03698523
56	response to pheromone (GO:0019236)	3.00664526
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.97470887
58	termination of RNA polymerase III transcription (GO:0006386)	2.97470887
59	ubiquinone metabolic process (GO:0006743)	2.91596977
60	regulation of cilium movement (GO:0003352)	2.90046568
61	single strand break repair (GO:0000012)	2.86396802
62	glial cell proliferation (GO:0014009)	2.84226170
63	tongue development (GO:0043586)	2.80933169
64	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.80064461
65	negative regulation of axon guidance (GO:1902668)	2.77049670
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.76604746
67	NADH dehydrogenase complex assembly (GO:0010257)	2.76604746
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.76604746
69	DNA double-strand break processing (GO:0000729)	2.76387394
70	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.76377837
71	protein heterotetramerization (GO:0051290)	2.75939326
72	photoreceptor cell development (GO:0042461)	2.75474550
73	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.74994108
74	glycerophospholipid catabolic process (GO:0046475)	2.74297037
75	embryonic epithelial tube formation (GO:0001838)	2.73952770
76	DNA integration (GO:0015074)	2.73949604
77	presynaptic membrane organization (GO:0097090)	2.73688635
78	inner ear receptor stereocilium organization (GO:0060122)	2.73214819
79	histone H2A acetylation (GO:0043968)	2.72459632
80	photoreceptor cell maintenance (GO:0045494)	2.71833813
81	tryptophan metabolic process (GO:0006568)	2.71558525
82	protein sumoylation (GO:0016925)	2.70905862
83	protein K6-linked ubiquitination (GO:0085020)	2.70012185
84	positive regulation of neurological system process (GO:0031646)	2.67878009
85	negative regulation of astrocyte differentiation (GO:0048712)	2.67597049
86	kynurenine metabolic process (GO:0070189)	2.67075330
87	viral mRNA export from host cell nucleus (GO:0046784)	2.64854125
88	short-term memory (GO:0007614)	2.64127510
89	dentate gyrus development (GO:0021542)	2.62199111
90	mitochondrial RNA metabolic process (GO:0000959)	2.61418800
91	positive regulation of glycogen biosynthetic process (GO:0045725)	2.61266120
92	rRNA methylation (GO:0031167)	2.60494383
93	rRNA modification (GO:0000154)	2.60382923
94	cardiac ventricle formation (GO:0003211)	2.57455510
95	behavioral response to ethanol (GO:0048149)	2.57003879
96	positive regulation of protein import into nucleus, translocation (GO:0033160)	2.55502645
97	male sex determination (GO:0030238)	2.55478826
98	regulation of timing of cell differentiation (GO:0048505)	2.55386029
99	heparin metabolic process (GO:0030202)	10.8180574
100	heparin biosynthetic process (GO:0030210)	10.8180574

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	6.72890502
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	5.93747634
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.05132439
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.03675113
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.01222376
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.92821928
7	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.84261430
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.83747338
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.66004848
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.65043508
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.59198466
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58153948
13	FUS_26573619_Chip-Seq_HEK293_Human	2.46916781
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.27533679
15	P300_19829295_ChIP-Seq_ESCs_Human	2.25351664
16	EWS_26573619_Chip-Seq_HEK293_Human	2.19992815
17	VDR_22108803_ChIP-Seq_LS180_Human	2.17352424
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15534359
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09510951
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07486407
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03514164
22	EZH2_22144423_ChIP-Seq_EOC_Human	2.01860313
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91692805
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88564477
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.83121749
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.78850082
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76784727
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63493524
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60511509
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58306811
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57803823
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57636788
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57263731
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56319946
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55350700
36	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55350700
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40752168
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39375612
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38033904
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37058721
41	TCF4_23295773_ChIP-Seq_U87_Human	1.36671775
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35212633
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34678726
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29742673
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29567795
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28221985
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28123888
48	TAF15_26573619_Chip-Seq_HEK293_Human	1.27858802
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25830461
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.25830461
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25563577
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23169298
53	AR_25329375_ChIP-Seq_VCAP_Human	1.22916442
54	STAT3_23295773_ChIP-Seq_U87_Human	1.21582715
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.21271259
56	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.20502531
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.20025319
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.19612419
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19612166
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17061195
61	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.16121100
62	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.14842464
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13400082
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12237558
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12159128
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11979130
67	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.11024310
68	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08124627
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06706917
70	JUN_21703547_ChIP-Seq_K562_Human	1.04878294
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04861680
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04824858
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04435871
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04435871
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04348886
76	KDM2B_26808549_Chip-Seq_REH_Human	1.01658440
77	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.01447772
78	VDR_23849224_ChIP-Seq_CD4+_Human	0.97840583
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96979839
80	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96937885
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96862746
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96862746
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95812582
84	BCAT_22108803_ChIP-Seq_LS180_Human	0.94551679
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94411386
86	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94188032
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94073819
88	SOX9_26525672_Chip-Seq_HEART_Mouse	0.93060712
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.91742097
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.91695381
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.91405538
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90855317
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90754188
94	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.90599749
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.90081057
96	EGR1_19032775_ChIP-ChIP_M12_Human	0.89926021
97	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89155664
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88933111
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.88264878
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.88102520

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	4.09115762
2	MP0003880_abnormal_central_pattern	3.86389323
3	MP0002102_abnormal_ear_morphology	3.26820303
4	MP0000566_synostosis	2.83941180
5	MP0006292_abnormal_olfactory_placode	2.70079266
6	MP0008789_abnormal_olfactory_epithelium	2.45059633
7	MP0005423_abnormal_somatic_nervous	2.33793557
8	MP0008058_abnormal_DNA_repair	2.32178481
9	MP0002938_white_spotting	2.26648453
10	MP0001984_abnormal_olfaction	2.24438853
11	MP0002282_abnormal_trachea_morphology	2.20473118
12	MP0006036_abnormal_mitochondrial_physio	2.19976430
13	MP0005248_abnormal_Harderian_gland	2.19747768
14	MP0005551_abnormal_eye_electrophysiolog	2.15148255
15	MP0009053_abnormal_anal_canal	2.12132483
16	MP0004147_increased_porphyrin_level	2.08580033
17	MP0000372_irregular_coat_pigmentation	1.99668656
18	MP0005499_abnormal_olfactory_system	1.96735441
19	MP0005394_taste/olfaction_phenotype	1.96735441
20	MP0008877_abnormal_DNA_methylation	1.96392631
21	MP0002090_abnormal_vision	1.85012356
22	MP0006276_abnormal_autonomic_nervous	1.74083465
23	MP0005253_abnormal_eye_physiology	1.73144945
24	MP0004043_abnormal_pH_regulation	1.62625483
25	MP0005365_abnormal_bile_salt	1.62509950
26	MP0002736_abnormal_nociception_after	1.59557836
27	MP0005408_hypopigmentation	1.57348130
28	MP0002697_abnormal_eye_size	1.56791334
29	MP0006035_abnormal_mitochondrial_morpho	1.56771829
30	MP0001486_abnormal_startle_reflex	1.55378971
31	MP0003938_abnormal_ear_development	1.52551309
32	MP0010030_abnormal_orbit_morphology	1.50657062
33	MP0003121_genomic_imprinting	1.50423584
34	MP0008775_abnormal_heart_ventricle	1.44938372
35	MP0003718_maternal_effect	1.39406386
36	MP0008875_abnormal_xenobiotic_pharmacok	1.38895900
37	MP0002332_abnormal_exercise_endurance	1.38323926
38	MP0010094_abnormal_chromosome_stability	1.36067077
39	MP0006072_abnormal_retinal_apoptosis	1.35310390
40	MP0000569_abnormal_digit_pigmentation	1.32969552
41	MP0003950_abnormal_plasma_membrane	1.29150499
42	MP0003011_delayed_dark_adaptation	1.27298529
43	MP0001299_abnormal_eye_distance/	1.26005942
44	MP0001968_abnormal_touch/_nociception	1.24185780
45	MP0002734_abnormal_mechanical_nocicepti	1.19627715
46	MP0000647_abnormal_sebaceous_gland	1.13047837
47	MP0002233_abnormal_nose_morphology	1.12696468
48	MP0001293_anophthalmia	1.09299942
49	MP0002653_abnormal_ependyma_morphology	1.04474766
50	MP0003937_abnormal_limbs/digits/tail_de	1.04204042
51	MP0005646_abnormal_pituitary_gland	1.03537669
52	MP0003646_muscle_fatigue	1.03207246
53	MP0000383_abnormal_hair_follicle	1.02102774
54	MP0008057_abnormal_DNA_replication	1.01481592
55	MP0005395_other_phenotype	1.00249555
56	MP0003119_abnormal_digestive_system	1.00215070
57	MP0005391_vision/eye_phenotype	0.99075754
58	MP0003786_premature_aging	0.98091316
59	MP0000778_abnormal_nervous_system	0.98085638
60	MP0005647_abnormal_sex_gland	0.97706543
61	MP0001986_abnormal_taste_sensitivity	0.97325769
62	MP0002095_abnormal_skin_pigmentation	0.96607991
63	MP0009046_muscle_twitch	0.96578137
64	MP0005195_abnormal_posterior_eye	0.96081232
65	MP0000428_abnormal_craniofacial_morphol	0.95290525
66	MP0001529_abnormal_vocalization	0.94966116
67	MP0002138_abnormal_hepatobiliary_system	0.91382854
68	MP0002168_other_aberrant_phenotype	0.90268727
69	MP0002160_abnormal_reproductive_system	0.89988655
70	MP0002638_abnormal_pupillary_reflex	0.89249484
71	MP0000427_abnormal_hair_cycle	0.88461888
72	MP0003698_abnormal_male_reproductive	0.87977833
73	MP0006054_spinal_hemorrhage	0.87736897
74	MP0001929_abnormal_gametogenesis	0.87182906
75	MP0002295_abnormal_pulmonary_circulatio	0.86444035
76	MP0003195_calcinosis	0.84862601
77	MP0003122_maternal_imprinting	0.84399738
78	MP0005310_abnormal_salivary_gland	0.83742926
79	MP0001853_heart_inflammation	0.82320284
80	MP0001145_abnormal_male_reproductive	0.81703924
81	MP0002751_abnormal_autonomic_nervous	0.81535091
82	MP0000653_abnormal_sex_gland	0.81238917
83	MP0001764_abnormal_homeostasis	0.80540363
84	MP0000631_abnormal_neuroendocrine_gland	0.78399787
85	MP0003111_abnormal_nucleus_morphology	0.78067265
86	MP0003136_yellow_coat_color	0.77734415
87	MP0009745_abnormal_behavioral_response	0.77418848
88	MP0005645_abnormal_hypothalamus_physiol	0.77071254
89	MP0003878_abnormal_ear_physiology	0.75179640
90	MP0005377_hearing/vestibular/ear_phenot	0.75179640
91	MP0002234_abnormal_pharynx_morphology	0.74501512
92	MP0002970_abnormal_white_adipose	0.73484550
93	MP0002752_abnormal_somatic_nervous	0.73002233
94	MP0000026_abnormal_inner_ear	0.71581502
95	MP0009765_abnormal_xenobiotic_induced	0.71322017
96	MP0001970_abnormal_pain_threshold	0.70826028
97	MP0001286_abnormal_eye_development	0.69650603
98	MP0001324_abnormal_eye_pigmentation	0.69323844
99	MP0003137_abnormal_impulse_conducting	0.69206308
100	MP0002735_abnormal_chemical_nociception	0.68675169

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplastic nipples (HP:0002557)	4.85547378
2	Medial flaring of the eyebrow (HP:0010747)	4.29708099
3	Intestinal atresia (HP:0011100)	4.23055524
4	Renal hypoplasia (HP:0000089)	4.14611685
5	Bifid scrotum (HP:0000048)	4.12811154
6	Congenital primary aphakia (HP:0007707)	4.11560275
7	Gait imbalance (HP:0002141)	4.07575861
8	True hermaphroditism (HP:0010459)	3.77375113
9	Nephrogenic diabetes insipidus (HP:0009806)	3.62628943
10	Zonular cataract (HP:0010920)	3.61105726
11	Abolished electroretinogram (ERG) (HP:0000550)	3.50361888
12	Bile duct proliferation (HP:0001408)	3.43722615
13	Abnormal biliary tract physiology (HP:0012439)	3.43722615
14	Molar tooth sign on MRI (HP:0002419)	3.25483282
15	Abnormality of midbrain morphology (HP:0002418)	3.25483282
16	Pancreatic fibrosis (HP:0100732)	3.09084431
17	Genital tract atresia (HP:0001827)	3.08130956
18	Hypoglycemic coma (HP:0001325)	3.08055492
19	Pancreatic cysts (HP:0001737)	3.07173581
20	Long foot (HP:0001833)	3.05201179
21	Nephronophthisis (HP:0000090)	3.03513497
22	Vaginal atresia (HP:0000148)	2.99640401
23	Wide intermamillary distance (HP:0006610)	2.95912794
24	Progressive inability to walk (HP:0002505)	2.90537659
25	Hyperventilation (HP:0002883)	2.71519108
26	Cortical dysplasia (HP:0002539)	2.68182790
27	Poor coordination (HP:0002370)	2.68109008
28	Hypoglycemic seizures (HP:0002173)	2.64940650
29	Growth hormone deficiency (HP:0000824)	2.64645462
30	Pancytopenia (HP:0001876)	2.59658193
31	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.50334818
32	Amyotrophic lateral sclerosis (HP:0007354)	2.45702680
33	Micropenis (HP:0000054)	2.42850984
34	Testicular atrophy (HP:0000029)	2.42239661
35	Congenital stationary night blindness (HP:0007642)	2.40591186
36	Abnormality of the lower motor neuron (HP:0002366)	2.39366625
37	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.38915937
38	Congenital cataract (HP:0000519)	2.38557391
39	Gastrointestinal atresia (HP:0002589)	2.37474676
40	Type II lissencephaly (HP:0007260)	2.36222950
41	Chronic hepatic failure (HP:0100626)	2.35534261
42	Postaxial hand polydactyly (HP:0001162)	2.35406813
43	Decreased testicular size (HP:0008734)	2.35197103
44	Pancreatic islet-cell hyperplasia (HP:0004510)	2.34326599
45	Bone marrow hypocellularity (HP:0005528)	2.31557888
46	Anencephaly (HP:0002323)	2.30376390
47	Multicystic kidney dysplasia (HP:0000003)	2.29965472
48	Carpal bone hypoplasia (HP:0001498)	2.29493174
49	Postaxial foot polydactyly (HP:0001830)	2.29147877
50	Astigmatism (HP:0000483)	2.26545262
51	Ectopic kidney (HP:0000086)	2.26440285
52	Retinal dysplasia (HP:0007973)	2.26108493
53	Abnormality of the renal medulla (HP:0100957)	2.25923459
54	Hip dysplasia (HP:0001385)	2.25477283
55	Chronic otitis media (HP:0000389)	2.25031024
56	3-Methylglutaconic aciduria (HP:0003535)	2.23358836
57	Tented upper lip vermilion (HP:0010804)	2.21915896
58	Cerebellar dysplasia (HP:0007033)	2.19636638
59	Inability to walk (HP:0002540)	2.17520789
60	Abnormal lung lobation (HP:0002101)	2.17296798
61	Small hand (HP:0200055)	2.15348085
62	Broad foot (HP:0001769)	2.13401843
63	Tubulointerstitial nephritis (HP:0001970)	2.12362027
64	Papillary thyroid carcinoma (HP:0002895)	2.12206899
65	Spinal muscular atrophy (HP:0007269)	2.08273138
66	Oligodactyly (HP:0012165)	2.07009217
67	Vitreoretinal degeneration (HP:0000655)	2.06317910
68	Gonadotropin excess (HP:0000837)	2.01493590
69	Abnormality of the aortic arch (HP:0012303)	2.01192487
70	Aplasia/Hypoplasia of the lens (HP:0008063)	1.99385568
71	CNS hypomyelination (HP:0003429)	1.97421117
72	Broad-based gait (HP:0002136)	1.96704066
73	Hyperglycinemia (HP:0002154)	1.95862008
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94542420
75	Aganglionic megacolon (HP:0002251)	1.92082298
76	Hypothermia (HP:0002045)	1.91996037
77	Congenital, generalized hypertrichosis (HP:0004540)	1.91898220
78	Preaxial hand polydactyly (HP:0001177)	1.91017648
79	Epidermoid cyst (HP:0200040)	1.89599684
80	Oculomotor apraxia (HP:0000657)	1.89490616
81	Specific learning disability (HP:0001328)	1.89176511
82	Microvesicular hepatic steatosis (HP:0001414)	1.88526260
83	Type I transferrin isoform profile (HP:0003642)	1.88377131
84	Enlarged penis (HP:0000040)	1.87212214
85	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85892671
86	Dandy-Walker malformation (HP:0001305)	1.82941428
87	Congenital sensorineural hearing impairment (HP:0008527)	1.82635508
88	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82272841
89	Secondary amenorrhea (HP:0000869)	1.81489391
90	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.80620594
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.79797963
92	Attenuation of retinal blood vessels (HP:0007843)	1.79327714
93	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.76806934
94	Dyskinesia (HP:0100660)	1.76062279
95	Abnormality of chromosome stability (HP:0003220)	1.75597187
96	Short foot (HP:0001773)	1.74683357
97	Ependymoma (HP:0002888)	1.74675604
98	Occipital encephalocele (HP:0002085)	1.74228478
99	Gaze-evoked nystagmus (HP:0000640)	1.74076875
100	Chromsome breakage (HP:0040012)	1.73807171

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	6.67732698
2	FRK	3.81044850
3	NUAK1	3.35780106
4	BCKDK	3.14785155
5	MAP3K4	3.07743628
6	JAK3	3.04997075
7	MAP3K10	2.74348142
8	CCNB1	2.27419096
9	MAP2K7	2.18126072
10	BMPR1B	2.07352961
11	PIK3CG	2.05202635
12	EPHA3	2.01482775
13	TRIM28	1.97730207
14	CDC7	1.71320993
15	LATS1	1.70247561
16	SRPK1	1.66784210
17	ACVR1B	1.57392758
18	FGFR2	1.51720495
19	ZAK	1.48051710
20	ADRBK2	1.46423195
21	STK39	1.38659235
22	WNK4	1.35036669
23	MAP3K6	1.33551003
24	GRK1	1.26109578
25	MAP2K4	1.25567444
26	STK3	1.20001187
27	FER	1.19614447
28	CAMK1D	1.18455311
29	TGFBR1	1.16979689
30	VRK1	1.16869290
31	CAMK1G	1.15703069
32	PINK1	1.13852726
33	MKNK1	1.12471462
34	GRK7	1.10048701
35	MARK1	1.09629424
36	MAP3K5	1.04454477
37	NME1	1.04265216
38	DAPK1	1.04039151
39	EPHA4	1.03502310
40	DYRK2	1.01801896
41	STK16	1.00201355
42	CASK	0.99755002
43	ERBB3	0.99598022
44	MAP3K12	0.99469674
45	WNK3	0.98910730
46	VRK2	0.90410125
47	MKNK2	0.90034470
48	PRKCE	0.89300731
49	TLK1	0.82547850
50	ERBB4	0.82494669
51	TEC	0.78266078
52	PLK3	0.77129693
53	OXSR1	0.74719650
54	PLK2	0.73435918
55	TIE1	0.72665485
56	ATR	0.68012458
57	ATM	0.66007105
58	ADRBK1	0.65932462
59	PRKAA1	0.64873556
60	IRAK1	0.63914388
61	STK38L	0.60212765
62	PLK4	0.59938647
63	DAPK2	0.59307481
64	MAPKAPK3	0.59243767
65	WNK1	0.57534218
66	CDK8	0.56263158
67	MAPK13	0.53736557
68	CSNK1D	0.51575064
69	CHEK2	0.51170228
70	RPS6KB1	0.48663486
71	DYRK1A	0.48136535
72	CSNK1G1	0.47217269
73	NEK1	0.44880884
74	MAP4K2	0.44595233
75	PRKCG	0.44070134
76	CDK3	0.43805505
77	CSNK1G2	0.43295460
78	PRKAA2	0.39988715
79	BUB1	0.39443665
80	BCR	0.39050350
81	PRKCB	0.38869107
82	MINK1	0.38731225
83	ITK	0.38233173
84	PBK	0.36699131
85	CDK9	0.36508369
86	CSNK1G3	0.36221037
87	PNCK	0.34300863
88	CSNK2A1	0.33181201
89	PLK1	0.30086207
90	PRKACA	0.29017202
91	CSNK1A1	0.28927487
92	CAMKK2	0.28505887
93	PRKDC	0.28022299
94	CHUK	0.27632063
95	TNIK	0.26312574
96	BMPR2	0.26297741
97	STK11	0.25178744
98	PRKACG	0.24170259
99	MAPKAPK5	0.23548376
100	PASK	0.22825205

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	5.05064363
2	RNA polymerase_Homo sapiens_hsa03020	3.85665222
3	Fanconi anemia pathway_Homo sapiens_hsa03460	3.83278229
4	Protein export_Homo sapiens_hsa03060	3.83265225
5	Homologous recombination_Homo sapiens_hsa03440	3.74672206
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.54877630
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.53551376
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.15185103
9	Propanoate metabolism_Homo sapiens_hsa00640	2.11704211
10	Fatty acid elongation_Homo sapiens_hsa00062	2.05356475
11	Proteasome_Homo sapiens_hsa03050	2.01535955
12	Base excision repair_Homo sapiens_hsa03410	1.94587699
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.84313708
14	Olfactory transduction_Homo sapiens_hsa04740	1.79941821
15	DNA replication_Homo sapiens_hsa03030	1.73861141
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.59978864
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54405974
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46167985
19	Phototransduction_Homo sapiens_hsa04744	1.46060230
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44753927
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.44321651
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.40806084
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33958242
24	Basal transcription factors_Homo sapiens_hsa03022	1.32674969
25	RNA transport_Homo sapiens_hsa03013	1.32041851
26	Lysine degradation_Homo sapiens_hsa00310	1.27184433
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24181764
28	Butanoate metabolism_Homo sapiens_hsa00650	1.16923582
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15985759
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12816957
31	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.09779437
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08422427
33	Spliceosome_Homo sapiens_hsa03040	1.07867154
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06012686
35	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.05836607
36	RNA degradation_Homo sapiens_hsa03018	1.05624343
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.04420933
38	Regulation of autophagy_Homo sapiens_hsa04140	1.04163673
39	mRNA surveillance pathway_Homo sapiens_hsa03015	0.99982757
40	Nicotine addiction_Homo sapiens_hsa05033	0.99004921
41	Mismatch repair_Homo sapiens_hsa03430	0.98800150
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98014134
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96929682
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96667313
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92894749
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91846178
47	Purine metabolism_Homo sapiens_hsa00230	0.90717637
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89831715
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.88842557
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.87005134
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82678902
52	Parkinsons disease_Homo sapiens_hsa05012	0.80816761
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79272825
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.78952881
55	Peroxisome_Homo sapiens_hsa04146	0.78695534
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.74166896
57	One carbon pool by folate_Homo sapiens_hsa00670	0.73627121
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71983230
59	Huntingtons disease_Homo sapiens_hsa05016	0.70057521
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69828837
61	Legionellosis_Homo sapiens_hsa05134	0.69210037
62	Alcoholism_Homo sapiens_hsa05034	0.69042102
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66285652
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65867715
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65480707
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65232684
67	Taste transduction_Homo sapiens_hsa04742	0.63373436
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60819830
69	Basal cell carcinoma_Homo sapiens_hsa05217	0.60692144
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.55804426
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.55109712
72	Caffeine metabolism_Homo sapiens_hsa00232	0.54455231
73	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.52038183
74	Metabolic pathways_Homo sapiens_hsa01100	0.51119264
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.48548099
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47176525
77	Morphine addiction_Homo sapiens_hsa05032	0.45678423
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.44594170
79	GABAergic synapse_Homo sapiens_hsa04727	0.43752260
80	Mineral absorption_Homo sapiens_hsa04978	0.42948161
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41978640
82	Histidine metabolism_Homo sapiens_hsa00340	0.41140060
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40037591
84	Retinol metabolism_Homo sapiens_hsa00830	0.38581930
85	Glutathione metabolism_Homo sapiens_hsa00480	0.35371940
86	Circadian rhythm_Homo sapiens_hsa04710	0.32711823
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32111588
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.31533944
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31286168
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.30542766
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.30253270
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29619477
93	Asthma_Homo sapiens_hsa05310	0.27885323
94	Fatty acid degradation_Homo sapiens_hsa00071	0.27236847
95	Alzheimers disease_Homo sapiens_hsa05010	0.22011579
96	p53 signaling pathway_Homo sapiens_hsa04115	0.18341453
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.18310462
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.18133638
99	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.17987627
100	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.16884105

HMGN1P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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