HMGN1P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA synthesis involved in DNA repair (GO:0000731)6.34524330
2L-methionine biosynthetic process from methylthioadenosine (GO:0019509)6.19972710
3fatty acid elongation (GO:0030497)5.46698308
4DNA deamination (GO:0045006)5.40960617
5L-methionine salvage (GO:0071267)5.25580466
6L-methionine biosynthetic process (GO:0071265)5.25580466
7amino acid salvage (GO:0043102)5.25580466
8cell wall macromolecule metabolic process (GO:0044036)5.02144037
9regulation of regulatory T cell differentiation (GO:0045589)4.91869701
10negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.91402843
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.72132470
12negative regulation of immunoglobulin mediated immune response (GO:0002890)4.69292829
13negative regulation of B cell mediated immunity (GO:0002713)4.69292829
14axoneme assembly (GO:0035082)4.61005166
15negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.60244530
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18400968
17cardiolipin metabolic process (GO:0032048)4.16493782
18pyrimidine dimer repair (GO:0006290)4.13871562
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.04555493
20termination of RNA polymerase III transcription (GO:0006386)4.04555493
21regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.83761654
22methionine biosynthetic process (GO:0009086)3.83037538
23positive regulation of lamellipodium assembly (GO:0010592)3.74442703
24synaptonemal complex organization (GO:0070193)3.72044832
25negative regulation of DNA recombination (GO:0045910)3.69631834
26cytidine metabolic process (GO:0046087)3.68766582
27cytidine catabolic process (GO:0006216)3.68766582
28cytidine deamination (GO:0009972)3.68766582
29regulation of isotype switching to IgG isotypes (GO:0048302)3.62080555
30synaptonemal complex assembly (GO:0007130)3.61938633
31tolerance induction (GO:0002507)3.61762757
32aspartate family amino acid biosynthetic process (GO:0009067)3.58634116
33glucosamine-containing compound catabolic process (GO:1901072)3.55860735
34regulation of helicase activity (GO:0051095)3.55651182
35response to pheromone (GO:0019236)3.52662965
36regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.52060438
37aspartate family amino acid catabolic process (GO:0009068)3.51432628
38regulation of coenzyme metabolic process (GO:0051196)3.50311358
39regulation of cofactor metabolic process (GO:0051193)3.50311358
40negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.42383721
41negative regulation of interleukin-1 beta production (GO:0032691)3.36322895
42regulation of acyl-CoA biosynthetic process (GO:0050812)3.35813265
43negative regulation of signal transduction by p53 class mediator (GO:1901797)3.30503428
44methionine metabolic process (GO:0006555)3.28231192
45immunoglobulin mediated immune response (GO:0016064)3.26526675
46negative regulation of neurotransmitter transport (GO:0051589)3.24228764
47negative regulation of T cell apoptotic process (GO:0070233)3.22626877
48peptidyl-histidine modification (GO:0018202)3.15238602
49negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.14197341
50negative regulation of T cell receptor signaling pathway (GO:0050860)3.13706237
51positive regulation of mitochondrial fission (GO:0090141)3.12622163
52pyrimidine ribonucleoside catabolic process (GO:0046133)3.11555939
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.11331843
54negative regulation of neurotransmitter secretion (GO:0046929)3.09700985
55positive regulation of B cell differentiation (GO:0045579)3.09458011
56leukocyte aggregation (GO:0070486)3.07358252
57neuronal action potential propagation (GO:0019227)3.04581516
58water-soluble vitamin biosynthetic process (GO:0042364)2.95955314
59proteasome assembly (GO:0043248)2.95799815
60base-excision repair, AP site formation (GO:0006285)2.94926794
61regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.94660448
62platelet dense granule organization (GO:0060155)2.94135062
63negative regulation of interleukin-1 production (GO:0032692)2.92431347
64dicarboxylic acid catabolic process (GO:0043649)2.84801972
65mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.84764444
66positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.84764444
67regulation of T cell receptor signaling pathway (GO:0050856)2.84333072
68positive regulation of tolerance induction (GO:0002645)2.83916206
69DNA double-strand break processing (GO:0000729)2.83064971
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.81784015
71negative regulation of protein acetylation (GO:1901984)2.79694631
72positive regulation of lamellipodium organization (GO:1902745)2.78982027
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.69343564
74aspartate family amino acid metabolic process (GO:0009066)2.67803179
75sulfur amino acid biosynthetic process (GO:0000097)2.67782166
76aldehyde catabolic process (GO:0046185)2.66229477
77positive regulation of protein homodimerization activity (GO:0090073)2.64895344
78regulation of glucokinase activity (GO:0033131)2.63871541
79regulation of hexokinase activity (GO:1903299)2.63871541
80protein prenylation (GO:0018342)2.63082616
81prenylation (GO:0097354)2.63082616
82glycosphingolipid biosynthetic process (GO:0006688)2.58667974
83regulation of B cell receptor signaling pathway (GO:0050855)2.57319949
84regulation of gamma-delta T cell differentiation (GO:0045586)2.54886220
85negative regulation of peptidyl-lysine acetylation (GO:2000757)2.53843951
86regulation of chronic inflammatory response (GO:0002676)2.53494465
87inositol phosphate dephosphorylation (GO:0046855)2.52175643
88phosphorylated carbohydrate dephosphorylation (GO:0046838)2.52175643
89isoprenoid biosynthetic process (GO:0008299)2.51216454
90epithelial cilium movement (GO:0003351)2.48587940
91production of molecular mediator involved in inflammatory response (GO:0002532)2.48409490
92single strand break repair (GO:0000012)2.46646034
93regulation of hydrogen peroxide metabolic process (GO:0010310)2.46209380
94negative regulation of membrane potential (GO:0045837)2.46115508
95negative regulation of mast cell activation (GO:0033004)2.45746603
96positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.42244283
97carnitine metabolic process (GO:0009437)2.41976297
98histone H2A ubiquitination (GO:0033522)2.40976966
99ganglioside metabolic process (GO:0001573)2.40957371
100positive T cell selection (GO:0043368)2.40097210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.66660572
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.00491807
3IGF1R_20145208_ChIP-Seq_DFB_Human3.70460311
4ZNF274_21170338_ChIP-Seq_K562_Hela2.88519061
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.76560775
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.51608655
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.33806415
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.29051430
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27819792
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23873017
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09354834
12GATA1_22025678_ChIP-Seq_K562_Human2.03415525
13ER_23166858_ChIP-Seq_MCF-7_Human2.02986283
14VDR_23849224_ChIP-Seq_CD4+_Human1.96434697
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88071218
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86930315
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79010800
18EWS_26573619_Chip-Seq_HEK293_Human1.78339322
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.77183760
20VDR_22108803_ChIP-Seq_LS180_Human1.71786529
21MYC_18940864_ChIP-ChIP_HL60_Human1.68257779
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67713071
23TP53_22573176_ChIP-Seq_HFKS_Human1.64884889
24RBPJ_21746931_ChIP-Seq_IB4_Human1.64784989
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60025097
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.58823783
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58431524
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.57077557
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56933925
30AR_20517297_ChIP-Seq_VCAP_Human1.56646303
31GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.53901787
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53841993
33RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.52136029
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51962504
35FUS_26573619_Chip-Seq_HEK293_Human1.51392088
36RUNX_20019798_ChIP-Seq_JUKART_Human1.50355400
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.47717273
38GATA6_21074721_ChIP-Seq_CACO-2_Human1.47236609
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47098669
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.46757216
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.44057460
42HTT_18923047_ChIP-ChIP_STHdh_Human1.43699857
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43094188
44GATA3_26560356_Chip-Seq_TH2_Human1.41771612
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.41513535
46ELK1_19687146_ChIP-ChIP_HELA_Human1.41245425
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40670137
48P300_19829295_ChIP-Seq_ESCs_Human1.38940257
49PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.38624936
50CDX2_22108803_ChIP-Seq_LS180_Human1.37841135
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.36952028
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36247189
53MYB_26560356_Chip-Seq_TH2_Human1.34979265
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34211438
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33661421
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31801611
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31373058
58GBX2_23144817_ChIP-Seq_PC3_Human1.31120197
59ETV1_20927104_ChIP-Seq_GIST48_Human1.29816559
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.29806706
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.29441386
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28487302
63PHF8_20622853_ChIP-Seq_HELA_Human1.27768394
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.26251540
65SMAD4_21799915_ChIP-Seq_A2780_Human1.25344122
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23079834
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22747717
68TAF15_26573619_Chip-Seq_HEK293_Human1.22390064
69GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20201865
70NCOR_22424771_ChIP-Seq_293T_Human1.19718157
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17756853
72P53_22387025_ChIP-Seq_ESCs_Mouse1.17312866
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16585618
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16143597
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.15553584
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14925567
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14901980
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.13837165
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12472177
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12182156
81CBP_20019798_ChIP-Seq_JUKART_Human1.12134189
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12134189
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11451359
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08360244
85AR_25329375_ChIP-Seq_VCAP_Human1.08127637
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07548019
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06806462
88HNFA_21074721_ChIP-Seq_CACO-2_Human1.06256946
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06250751
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06203347
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.06203347
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05530240
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05331382
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05292360
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05133472
96TCF4_22108803_ChIP-Seq_LS180_Human1.04882753
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04528667
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04267418
99P300_18555785_Chip-Seq_ESCs_Mouse1.03889352
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02778011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.42460574
2MP0000372_irregular_coat_pigmentation3.64195527
3MP0005171_absent_coat_pigmentation3.59539762
4MP0008058_abnormal_DNA_repair3.40703457
5MP0003136_yellow_coat_color3.21936239
6MP0001873_stomach_inflammation2.98211333
7MP0009697_abnormal_copulation2.85967570
8MP0006072_abnormal_retinal_apoptosis2.52138228
9MP0008877_abnormal_DNA_methylation2.43438167
10MP0005671_abnormal_response_to2.42242635
11MP0005174_abnormal_tail_pigmentation2.23889995
12MP0008995_early_reproductive_senescence2.19378504
13MP0002837_dystrophic_cardiac_calcinosis2.18734542
14MP0000015_abnormal_ear_pigmentation2.05135321
15MP0002638_abnormal_pupillary_reflex2.04775392
16MP0000569_abnormal_digit_pigmentation1.99243435
17MP0004381_abnormal_hair_follicle1.97753138
18MP0004043_abnormal_pH_regulation1.91518670
19MP0005646_abnormal_pituitary_gland1.90641354
20MP0002166_altered_tumor_susceptibility1.85540734
21MP0005085_abnormal_gallbladder_physiolo1.60628231
22MP0001986_abnormal_taste_sensitivity1.59788253
23MP0009333_abnormal_splenocyte_physiolog1.55415248
24MP0005084_abnormal_gallbladder_morpholo1.54040795
25MP0005551_abnormal_eye_electrophysiolog1.50225614
26MP0002277_abnormal_respiratory_mucosa1.43718651
27MP0002102_abnormal_ear_morphology1.32333331
28MP0001984_abnormal_olfaction1.31845362
29MP0001835_abnormal_antigen_presentation1.30263598
30MP0005253_abnormal_eye_physiology1.28633418
31MP0002095_abnormal_skin_pigmentation1.23820937
32MP0006276_abnormal_autonomic_nervous1.23129317
33MP0001501_abnormal_sleep_pattern1.22361937
34MP0002009_preneoplasia1.22247056
35MP0001968_abnormal_touch/_nociception1.20879874
36MP0000465_gastrointestinal_hemorrhage1.19550096
37MP0002736_abnormal_nociception_after1.17579018
38MP0005360_urolithiasis1.15936187
39MP0002006_tumorigenesis1.13422363
40MP0003137_abnormal_impulse_conducting1.10920403
41MP0009745_abnormal_behavioral_response1.10084700
42MP0001905_abnormal_dopamine_level1.09071034
43MP0002877_abnormal_melanocyte_morpholog1.09041060
44MP0005645_abnormal_hypothalamus_physiol1.08795272
45MP0006082_CNS_inflammation1.05475842
46MP0003638_abnormal_response/metabolism_1.04847167
47MP0002272_abnormal_nervous_system1.03411244
48MP0009046_muscle_twitch1.03249074
49MP0005332_abnormal_amino_acid1.03131934
50MP0003718_maternal_effect1.02708230
51MP0003763_abnormal_thymus_physiology1.01093890
52MP0002405_respiratory_system_inflammati0.97548013
53MP0005365_abnormal_bile_salt0.95940374
54MP0008961_abnormal_basal_metabolism0.94845268
55MP0005083_abnormal_biliary_tract0.94570248
56MP0006036_abnormal_mitochondrial_physio0.92128008
57MP0009785_altered_susceptibility_to0.91621147
58MP0001800_abnormal_humoral_immune0.90142904
59MP0005075_abnormal_melanosome_morpholog0.88801982
60MP0005647_abnormal_sex_gland0.88066241
61MP0003252_abnormal_bile_duct0.87681842
62MP0004142_abnormal_muscle_tone0.87508762
63MP0001661_extended_life_span0.86714584
64MP0002933_joint_inflammation0.86562857
65MP0001486_abnormal_startle_reflex0.86343933
66MP0005000_abnormal_immune_tolerance0.85827817
67MP0001440_abnormal_grooming_behavior0.83866593
68MP0009763_increased_sensitivity_to0.83004737
69MP0004134_abnormal_chest_morphology0.82350115
70MP0002653_abnormal_ependyma_morphology0.82031067
71MP0004145_abnormal_muscle_electrophysio0.81891689
72MP0001663_abnormal_digestive_system0.80833425
73MP0003315_abnormal_perineum_morphology0.80533028
74MP0002928_abnormal_bile_duct0.80131147
75MP0002229_neurodegeneration0.79870080
76MP0003879_abnormal_hair_cell0.78057565
77MP0002572_abnormal_emotion/affect_behav0.77647429
78MP0005310_abnormal_salivary_gland0.75630137
79MP0002148_abnormal_hypersensitivity_rea0.75300973
80MP0005187_abnormal_penis_morphology0.75011559
81MP0002160_abnormal_reproductive_system0.74919663
82MP0008872_abnormal_physiological_respon0.74349626
83MP0003787_abnormal_imprinting0.72712193
84MP0005389_reproductive_system_phenotype0.72588061
85MP0001542_abnormal_bone_strength0.70195239
86MP0002557_abnormal_social/conspecific_i0.69383376
87MP0001929_abnormal_gametogenesis0.68616027
88MP0000689_abnormal_spleen_morphology0.67010792
89MP0002723_abnormal_immune_serum0.66505563
90MP0002420_abnormal_adaptive_immunity0.66458795
91MP0001191_abnormal_skin_condition0.65799595
92MP0001188_hyperpigmentation0.64702352
93MP0005410_abnormal_fertilization0.64509196
94MP0005535_abnormal_body_temperature0.64397534
95MP0004147_increased_porphyrin_level0.63462620
96MP0005367_renal/urinary_system_phenotyp0.63153193
97MP0000516_abnormal_urinary_system0.63153193
98MP0002452_abnormal_antigen_presenting0.62877330
99MP0000013_abnormal_adipose_tissue0.62727231
100MP0003866_abnormal_defecation0.62699406

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.34289800
2Molar tooth sign on MRI (HP:0002419)4.24291610
3Abnormality of midbrain morphology (HP:0002418)4.24291610
4Pancreatic cysts (HP:0001737)3.64649134
5Posterior subcapsular cataract (HP:0007787)3.58021862
6Abnormality of the fovea (HP:0000493)3.46678682
7Limb dystonia (HP:0002451)3.44456516
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.37281799
9Hypoplasia of the fovea (HP:0007750)3.37281799
10Hypothermia (HP:0002045)3.24180219
11Microretrognathia (HP:0000308)3.16562585
12Absent rod-and cone-mediated responses on ERG (HP:0007688)2.86338712
13Hypoproteinemia (HP:0003075)2.82917000
143-Methylglutaconic aciduria (HP:0003535)2.79610376
15Delusions (HP:0000746)2.74753888
16Intrahepatic cholestasis (HP:0001406)2.71759925
17Sensorimotor neuropathy (HP:0007141)2.70355177
18Abnormality of the prostate (HP:0008775)2.68714982
19Methylmalonic acidemia (HP:0002912)2.65114802
20Decreased central vision (HP:0007663)2.62127904
21Abnormality of alanine metabolism (HP:0010916)2.60566634
22Hyperalaninemia (HP:0003348)2.60566634
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60566634
24Congenital sensorineural hearing impairment (HP:0008527)2.59800250
25Lip pit (HP:0100267)2.56898094
26Abnormality of macular pigmentation (HP:0008002)2.51990610
27Attenuation of retinal blood vessels (HP:0007843)2.47601820
28Gastrointestinal infarctions (HP:0005244)2.44616021
29Cystic liver disease (HP:0006706)2.43711709
30Aplasia/hypoplasia of the uterus (HP:0008684)2.42624542
31Aplasia/Hypoplasia of the macula (HP:0008059)2.36643069
32Spastic paraparesis (HP:0002313)2.31791714
33Absent speech (HP:0001344)2.30199400
34Ileus (HP:0002595)2.29930557
35Stomach cancer (HP:0012126)2.26380365
36Unsteady gait (HP:0002317)2.25958763
37Elevated erythrocyte sedimentation rate (HP:0003565)2.23899238
38Aplasia/Hypoplasia affecting the retina (HP:0008061)2.22864199
39Hyperglycinuria (HP:0003108)2.22711641
40Hypoplasia of the uterus (HP:0000013)2.19681159
41Tetraparesis (HP:0002273)2.19493384
42Submucous cleft hard palate (HP:0000176)2.18083298
43Abnormality of serine family amino acid metabolism (HP:0010894)2.17866324
44Abnormality of glycine metabolism (HP:0010895)2.17866324
45Albinism (HP:0001022)2.14494576
46Reduced antithrombin III activity (HP:0001976)2.14429624
47Congenital stationary night blindness (HP:0007642)2.10991981
48True hermaphroditism (HP:0010459)2.10167818
49Pancreatic fibrosis (HP:0100732)2.09422196
50Abnormal protein glycosylation (HP:0012346)2.08905351
51Abnormal glycosylation (HP:0012345)2.08905351
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08905351
53Abnormal protein N-linked glycosylation (HP:0012347)2.08905351
54Cutaneous melanoma (HP:0012056)2.08426810
55Acute necrotizing encephalopathy (HP:0006965)2.06531169
56Generalized aminoaciduria (HP:0002909)2.05298294
57Optic disc pallor (HP:0000543)2.04378530
58Abnormal rod and cone electroretinograms (HP:0008323)2.04375041
59Cerebral hypomyelination (HP:0006808)2.02923152
60Reduced subcutaneous adipose tissue (HP:0003758)2.02513162
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02369080
62Abnormality of vitamin B metabolism (HP:0004340)2.01508258
63Pendular nystagmus (HP:0012043)2.01114546
64Increased serum pyruvate (HP:0003542)2.00820010
65Amyotrophic lateral sclerosis (HP:0007354)1.97586979
66Concave nail (HP:0001598)1.91064319
67Thyroiditis (HP:0100646)1.90884013
68Patchy hypopigmentation of hair (HP:0011365)1.89901411
69Broad alveolar ridges (HP:0000187)1.89594924
70Methylmalonic aciduria (HP:0012120)1.88532398
71Abnormality of urine glucose concentration (HP:0011016)1.88158155
72Glycosuria (HP:0003076)1.88158155
73Nephrogenic diabetes insipidus (HP:0009806)1.87965407
74Autoimmune hemolytic anemia (HP:0001890)1.86581917
75Hyperammonemia (HP:0001987)1.86266950
76Colon cancer (HP:0003003)1.85273780
77Progressive macrocephaly (HP:0004481)1.84912576
78Lethargy (HP:0001254)1.83699217
79Dyskinesia (HP:0100660)1.83400721
80Type I transferrin isoform profile (HP:0003642)1.83289560
81Abnormal mitochondria in muscle tissue (HP:0008316)1.83032052
82Nephronophthisis (HP:0000090)1.82930384
83Severe combined immunodeficiency (HP:0004430)1.82691819
84Cerebral edema (HP:0002181)1.82540735
85Abnormality of liposaccharide metabolism (HP:0010968)1.81295813
86Abnormality of glycosphingolipid metabolism (HP:0004343)1.81295813
87Abnormality of glycolipid metabolism (HP:0010969)1.81295813
88Abnormality of the vitamin B12 metabolism (HP:0004341)1.80704375
89Nausea (HP:0002018)1.80244081
90Bilateral sensorineural hearing impairment (HP:0008619)1.79615990
91Agitation (HP:0000713)1.78047377
92Encephalitis (HP:0002383)1.77780313
93Gangrene (HP:0100758)1.77244014
94Lissencephaly (HP:0001339)1.72669369
95Type II lissencephaly (HP:0007260)1.72149401
96Anhidrosis (HP:0000970)1.72040362
97Abnormality of binocular vision (HP:0011514)1.71648729
98Diplopia (HP:0000651)1.71648729
99Abolished electroretinogram (ERG) (HP:0000550)1.70135040
100Increased hepatocellular lipid droplets (HP:0006565)1.69233956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.49932905
2MUSK3.62321958
3NUAK13.55469273
4PAK33.08350493
5FRK2.80622249
6FER2.70955254
7TRIM282.43270484
8AKT32.34620662
9TAOK32.26631303
10MAP3K62.14802414
11FES2.09336013
12MKNK11.93314548
13NEK11.93281557
14GRK61.86379319
15KDR1.71168808
16GRK71.64725573
17RAF11.58470097
18PDK21.56147532
19TLK11.55691655
20BCR1.52383457
21EIF2AK31.52219542
22GRK11.48277912
23PAK61.46584793
24MAPKAPK51.46442558
25TESK21.42788906
26MARK31.31623969
27CSNK1G21.30554693
28CSNK1G31.30209312
29ADRBK21.29463768
30ERBB31.28385983
31VRK11.24974921
32RPS6KA41.22766779
33MAP2K11.21672410
34PRKCI1.13445419
35PINK11.10252731
36MKNK21.08170530
37DMPK1.06545862
38PLK21.04025691
39ZAK1.01679942
40DYRK30.99983521
41STK380.99373636
42TYRO30.98524699
43MATK0.97232408
44CSNK1G10.95942875
45CSK0.95875081
46TAOK10.91320983
47VRK20.88009261
48CSNK1A1L0.87345841
49PLK30.85687138
50RPS6KA50.84646171
51LCK0.83085378
52PIM20.82576691
53PRKCE0.81560144
54MAP3K50.79714075
55MAPK130.77463657
56SIK30.73573143
57WNK30.72081058
58INSRR0.71510856
59TSSK60.70284398
60STK160.70273346
61CAMKK20.67214639
62FGFR10.65087789
63BCKDK0.65014828
64ADRBK10.62458147
65GRK50.61457530
66MAP4K20.59602353
67STK30.58832659
68CAMK2A0.57588879
69PHKG10.56412343
70PHKG20.56412343
71PAK10.51692631
72EGFR0.51150338
73PIM10.51101556
74ABL10.50774487
75MINK10.50305513
76TRPM70.50207223
77PRKCH0.49094524
78PIK3CA0.48768186
79IGF1R0.46133918
80DAPK20.45366978
81PRKACG0.43593342
82BRSK10.43382192
83OXSR10.42322867
84MAP3K20.40968060
85MST40.40803018
86STK38L0.39321376
87PRKACA0.39065768
88PRKAA10.36930581
89PRKCQ0.35409039
90WNK40.34666888
91PRKCA0.34626245
92TNK20.34359775
93PLK40.33821485
94PRKCG0.33557866
95MAPK30.32920217
96PRKD20.32253804
97RPS6KA10.31910064
98FGR0.31585384
99PRKG10.31056605
100SYK0.30920456

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.15465366
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.43424999
3Proteasome_Homo sapiens_hsa030502.98172121
4RNA polymerase_Homo sapiens_hsa030202.70966236
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.69118989
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50967773
7Protein export_Homo sapiens_hsa030602.19804321
8Fatty acid metabolism_Homo sapiens_hsa012122.19082283
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07716569
10Butanoate metabolism_Homo sapiens_hsa006502.01669091
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00640907
12Linoleic acid metabolism_Homo sapiens_hsa005911.96797335
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96463814
14Oxidative phosphorylation_Homo sapiens_hsa001901.90073614
15Phototransduction_Homo sapiens_hsa047441.87794278
16Nitrogen metabolism_Homo sapiens_hsa009101.73820097
17Propanoate metabolism_Homo sapiens_hsa006401.72360596
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70703435
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64708377
20Ether lipid metabolism_Homo sapiens_hsa005651.59384623
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59003583
22Parkinsons disease_Homo sapiens_hsa050121.58757384
23Regulation of autophagy_Homo sapiens_hsa041401.54314717
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50893013
25Autoimmune thyroid disease_Homo sapiens_hsa053201.48096286
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40973145
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36127905
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35676549
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32243972
30Basal transcription factors_Homo sapiens_hsa030221.31430299
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.29025070
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27840510
33Selenocompound metabolism_Homo sapiens_hsa004501.20954835
34Peroxisome_Homo sapiens_hsa041461.20948200
35Fatty acid degradation_Homo sapiens_hsa000711.19547195
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.19358667
37Sulfur metabolism_Homo sapiens_hsa009201.18125500
38Other glycan degradation_Homo sapiens_hsa005111.16413131
39Type I diabetes mellitus_Homo sapiens_hsa049401.06747533
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05658460
41Primary immunodeficiency_Homo sapiens_hsa053401.04290059
42beta-Alanine metabolism_Homo sapiens_hsa004101.01618039
43Graft-versus-host disease_Homo sapiens_hsa053321.00732051
44Allograft rejection_Homo sapiens_hsa053301.00337892
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99602516
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99530837
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99446879
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96876697
49Shigellosis_Homo sapiens_hsa051310.94922397
50Rheumatoid arthritis_Homo sapiens_hsa053230.91281591
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88854800
52Alzheimers disease_Homo sapiens_hsa050100.87935079
53Arachidonic acid metabolism_Homo sapiens_hsa005900.87170181
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.86735262
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86073488
56Collecting duct acid secretion_Homo sapiens_hsa049660.85750273
57Olfactory transduction_Homo sapiens_hsa047400.85721542
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.85548811
59Chemical carcinogenesis_Homo sapiens_hsa052040.82995013
60Tryptophan metabolism_Homo sapiens_hsa003800.80813711
61Ovarian steroidogenesis_Homo sapiens_hsa049130.80764089
62Asthma_Homo sapiens_hsa053100.74157409
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70762692
64Synaptic vesicle cycle_Homo sapiens_hsa047210.70548740
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70359110
66Hematopoietic cell lineage_Homo sapiens_hsa046400.69379547
67Viral myocarditis_Homo sapiens_hsa054160.68375054
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66607835
69Taste transduction_Homo sapiens_hsa047420.64205705
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61894778
71Long-term depression_Homo sapiens_hsa047300.61374111
72Amphetamine addiction_Homo sapiens_hsa050310.60077507
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.56978665
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56655829
75Huntingtons disease_Homo sapiens_hsa050160.55932169
76Metabolic pathways_Homo sapiens_hsa011000.54305094
77Serotonergic synapse_Homo sapiens_hsa047260.54239622
78Systemic lupus erythematosus_Homo sapiens_hsa053220.52157163
79Antigen processing and presentation_Homo sapiens_hsa046120.50977925
80Steroid biosynthesis_Homo sapiens_hsa001000.50465944
81Glycerolipid metabolism_Homo sapiens_hsa005610.49727716
82Caffeine metabolism_Homo sapiens_hsa002320.49051859
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.48751495
84ABC transporters_Homo sapiens_hsa020100.44057622
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43813608
86Spliceosome_Homo sapiens_hsa030400.41926137
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40415721
88Fat digestion and absorption_Homo sapiens_hsa049750.40159756
89Retinol metabolism_Homo sapiens_hsa008300.37287881
90Pyrimidine metabolism_Homo sapiens_hsa002400.37130529
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36719875
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36144263
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35230193
94Nicotine addiction_Homo sapiens_hsa050330.35170764
95Salivary secretion_Homo sapiens_hsa049700.34859959
96Circadian rhythm_Homo sapiens_hsa047100.34761788
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32309609
98RNA transport_Homo sapiens_hsa030130.31534971
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30487779
100Tyrosine metabolism_Homo sapiens_hsa003500.30099868

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