HMGN1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UMP biosynthetic process (GO:0006222)5.77520921
2pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)5.77520921
3UMP metabolic process (GO:0046049)5.77520921
4pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)5.77520921
5regulation of vacuole organization (GO:0044088)5.34643747
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.00602291
7neuronal action potential propagation (GO:0019227)4.98308219
8barbed-end actin filament capping (GO:0051016)4.50219613
9protein prenylation (GO:0018342)4.37745945
10prenylation (GO:0097354)4.37745945
11positive regulation of protein homooligomerization (GO:0032464)4.25542645
12pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.13196674
13ventricular septum development (GO:0003281)4.12001730
14myelin assembly (GO:0032288)4.10548397
15pyrimidine-containing compound salvage (GO:0008655)4.09103681
16pyrimidine nucleoside salvage (GO:0043097)4.09103681
17regulation of non-canonical Wnt signaling pathway (GO:2000050)3.95236560
18tongue development (GO:0043586)3.86025181
19artery development (GO:0060840)3.76733243
20gamma-aminobutyric acid transport (GO:0015812)3.76156878
21blood vessel maturation (GO:0001955)3.74127020
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69635271
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.69635271
24protein localization to microtubule cytoskeleton (GO:0072698)3.68631200
25negative regulation of activin receptor signaling pathway (GO:0032926)3.67738381
26pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.58212980
27negative regulation of macrophage differentiation (GO:0045650)3.50070021
28regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.48785828
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.47466288
30sulfur amino acid catabolic process (GO:0000098)3.46886949
31behavioral response to nicotine (GO:0035095)3.44089233
32nucleotide salvage (GO:0043173)3.42828118
33regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.42187237
34regulation of chemokine-mediated signaling pathway (GO:0070099)3.41737689
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32611913
36base-excision repair, AP site formation (GO:0006285)3.29723909
37protein localization to cytoskeleton (GO:0044380)3.18287943
38detection of light stimulus involved in sensory perception (GO:0050962)3.12472054
39detection of light stimulus involved in visual perception (GO:0050908)3.12472054
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.12057546
41positive regulation of cardiac muscle cell differentiation (GO:2000727)3.09593889
42cellular response to ATP (GO:0071318)2.99302630
43G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.98481656
44pathway-restricted SMAD protein phosphorylation (GO:0060389)2.96825029
45cardiac septum development (GO:0003279)2.92129236
46cytochrome complex assembly (GO:0017004)2.91668943
47ER overload response (GO:0006983)2.90100893
48nucleoside salvage (GO:0043174)2.85305774
49snRNA transcription (GO:0009301)2.83780119
50pre-miRNA processing (GO:0031054)2.83746408
51protein retention in ER lumen (GO:0006621)2.80623160
52face morphogenesis (GO:0060325)2.76676511
53pyrimidine ribonucleotide metabolic process (GO:0009218)2.75454780
54pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.74678536
55cellular modified amino acid catabolic process (GO:0042219)2.73757893
56protein-chromophore linkage (GO:0018298)2.73426836
57NLS-bearing protein import into nucleus (GO:0006607)2.72189191
58negative regulation of axon guidance (GO:1902668)2.71622141
59inner ear receptor cell development (GO:0060119)2.68156832
60peptidyl-proline hydroxylation (GO:0019511)2.67693047
61pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.65248368
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.65248264
63epithelial cilium movement (GO:0003351)2.64639108
64negative regulation of macroautophagy (GO:0016242)2.61434553
65interkinetic nuclear migration (GO:0022027)2.60514218
66UDP-N-acetylglucosamine metabolic process (GO:0006047)2.56182934
67positive regulation of synapse assembly (GO:0051965)2.55947131
68regulation of macroautophagy (GO:0016241)2.55202546
69cyclooxygenase pathway (GO:0019371)2.54544451
70photoreceptor cell maintenance (GO:0045494)2.54451438
71pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.54390055
72negative regulation of translation, ncRNA-mediated (GO:0040033)2.54056703
73regulation of translation, ncRNA-mediated (GO:0045974)2.54056703
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54056703
75cilium morphogenesis (GO:0060271)2.53176424
76pharyngeal system development (GO:0060037)2.49889188
77regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.48296331
78rRNA catabolic process (GO:0016075)2.47826777
79sequestering of extracellular ligand from receptor (GO:0035581)2.45613116
80regulation of autophagic vacuole assembly (GO:2000785)2.45318058
81maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43372997
82blastocyst development (GO:0001824)2.43107345
83respiratory chain complex IV assembly (GO:0008535)2.42802891
84negative regulation of systemic arterial blood pressure (GO:0003085)2.42514684
85positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.41786907
86regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.41786907
87regulation of telomere maintenance via telomerase (GO:0032210)2.41398589
88mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.41015225
89positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.41015225
90pericardium development (GO:0060039)2.41014482
91ncRNA catabolic process (GO:0034661)2.40931126
92negative regulation of axon extension involved in axon guidance (GO:0048843)2.40817105
93pyrimidine ribonucleoside metabolic process (GO:0046131)2.40423441
94peristalsis (GO:0030432)2.38257569
95establishment of protein localization to Golgi (GO:0072600)2.37838949
96cilium movement (GO:0003341)2.37295797
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.36755296
98mitochondrion transport along microtubule (GO:0047497)2.36755296
99GMP metabolic process (GO:0046037)2.36749494
100embryonic hemopoiesis (GO:0035162)2.35985047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.34681638
2VDR_22108803_ChIP-Seq_LS180_Human4.55843873
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.62087161
4TP53_16413492_ChIP-PET_HCT116_Human3.05784624
5GBX2_23144817_ChIP-Seq_PC3_Human3.02538544
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97566146
7ZNF274_21170338_ChIP-Seq_K562_Hela2.77837789
8EZH2_22144423_ChIP-Seq_EOC_Human2.50080750
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38597129
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.33941014
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32434418
12CJUN_26792858_Chip-Seq_BT549_Human2.27389380
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15569559
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05675818
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05447383
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01922477
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.99781351
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97896280
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.97785744
20BRD4_25478319_ChIP-Seq_HGPS_Human1.84385378
21TP53_18474530_ChIP-ChIP_U2OS_Human1.79433531
22BCAT_22108803_ChIP-Seq_LS180_Human1.78452711
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76760576
24ETV2_25802403_ChIP-Seq_MESCs_Mouse1.70324431
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.64535245
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63728804
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60296720
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60290655
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59664232
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55920058
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54866195
32LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53730110
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53234129
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52492833
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.50771632
36TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50165138
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44110510
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38408380
39HTT_18923047_ChIP-ChIP_STHdh_Human1.36363830
40SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.36170313
41ER_23166858_ChIP-Seq_MCF-7_Human1.35603567
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35404518
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35404518
44JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32199042
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30981392
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.29727624
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.28514836
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27694632
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27509101
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25910652
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22193451
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22193451
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21634239
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17653698
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17606415
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17316441
57P300_19829295_ChIP-Seq_ESCs_Human1.15873913
58TBL1_22424771_ChIP-Seq_293T_Human1.15605786
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15496397
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14892625
61AR_25329375_ChIP-Seq_VCAP_Human1.13800315
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12612826
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10219002
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07619260
65CBP_20019798_ChIP-Seq_JUKART_Human1.07619260
66JUN_21703547_ChIP-Seq_K562_Human1.05899420
67KDM2B_26808549_Chip-Seq_REH_Human1.05400032
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.04818555
69CBP_21632823_ChIP-Seq_H3396_Human1.04281043
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.03540651
71STAT3_23295773_ChIP-Seq_U87_Human1.03476196
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02361321
73TAF15_26573619_Chip-Seq_HEK293_Human1.02258385
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01014259
75PHF8_20622853_ChIP-Seq_HELA_Human1.00511088
76SMAD_19615063_ChIP-ChIP_OVARY_Human0.99709066
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99379473
78TP63_23658742_ChIP-Seq_EP156T_Human0.98009280
79AHR_22903824_ChIP-Seq_MCF-7_Human0.97069255
80TCF4_23295773_ChIP-Seq_U87_Human0.95887527
81GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.94925084
82STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94798319
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93757921
84SMAD4_21799915_ChIP-Seq_A2780_Human0.93542568
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92714028
86RUNX2_22187159_ChIP-Seq_PCA_Human0.92573763
87CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92353719
88SOX9_26525672_Chip-Seq_HEART_Mouse0.91857711
89ELK1_19687146_ChIP-ChIP_HELA_Human0.91763506
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91379903
91LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91207847
92GF1B_26923725_Chip-Seq_HPCs_Mouse0.89250479
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89056964
94RXR_22108803_ChIP-Seq_LS180_Human0.87577774
95TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87354597
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87326709
97SOX2_21211035_ChIP-Seq_LN229_Gbm0.86943100
98NFYA_21822215_ChIP-Seq_K562_Human0.86901252
99GF1_26923725_Chip-Seq_HPCs_Mouse0.86277767
100TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85705791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.12795100
2MP0009780_abnormal_chondrocyte_physiolo3.77724997
3MP0002102_abnormal_ear_morphology3.75364367
4MP0004133_heterotaxia3.34295295
5MP0005623_abnormal_meninges_morphology3.17377902
6MP0002837_dystrophic_cardiac_calcinosis3.14824804
7MP0002938_white_spotting2.94537744
8MP0008438_abnormal_cutaneous_collagen2.81695420
9MP0002254_reproductive_system_inflammat2.44797294
10MP0001542_abnormal_bone_strength2.41102964
11MP0008058_abnormal_DNA_repair2.32700661
12MP0003656_abnormal_erythrocyte_physiolo2.23711114
13MP0010030_abnormal_orbit_morphology2.18693112
14MP0003566_abnormal_cell_adhesion2.03734887
15MP0003705_abnormal_hypodermis_morpholog1.91244146
16MP0000013_abnormal_adipose_tissue1.79295623
17MP0005503_abnormal_tendon_morphology1.77249636
18MP0004233_abnormal_muscle_weight1.71655108
19MP0003755_abnormal_palate_morphology1.63930694
20MP0004885_abnormal_endolymph1.62174981
21MP0003693_abnormal_embryo_hatching1.59854884
22MP0003941_abnormal_skin_development1.59145662
23MP0003385_abnormal_body_wall1.58409611
24MP0010368_abnormal_lymphatic_system1.43232400
25MP0003937_abnormal_limbs/digits/tail_de1.42820612
26MP0009053_abnormal_anal_canal1.42579592
27MP0005023_abnormal_wound_healing1.38632581
28MP0000003_abnormal_adipose_tissue1.36161436
29MP0000749_muscle_degeneration1.35335670
30MP0002282_abnormal_trachea_morphology1.34632757
31MP0000432_abnormal_head_morphology1.33338877
32MP0009046_muscle_twitch1.27526866
33MP0001243_abnormal_dermal_layer1.25231378
34MP0003828_pulmonary_edema1.23543555
35MP0005410_abnormal_fertilization1.23296449
36MP0000613_abnormal_salivary_gland1.23296066
37MP0002060_abnormal_skin_morphology1.22271360
38MP0005408_hypopigmentation1.19496653
39MP0001501_abnormal_sleep_pattern1.19013462
40MP0000751_myopathy1.15121781
41MP0000762_abnormal_tongue_morphology1.14970190
42MP0000358_abnormal_cell_content/1.14355116
43MP0003091_abnormal_cell_migration1.14220061
44MP0000767_abnormal_smooth_muscle1.12505302
45MP0005164_abnormal_response_to1.11576437
46MP0005508_abnormal_skeleton_morphology1.10111504
47MP0003786_premature_aging1.06401226
48MP0009250_abnormal_appendicular_skeleto1.05084556
49MP0002928_abnormal_bile_duct1.04786773
50MP0000049_abnormal_middle_ear1.02283270
51MP0008775_abnormal_heart_ventricle1.01566340
52MP0000467_abnormal_esophagus_morphology1.01300982
53MP0002896_abnormal_bone_mineralization0.99265472
54MP0008789_abnormal_olfactory_epithelium0.95558312
55MP0002653_abnormal_ependyma_morphology0.94189571
56MP0000566_synostosis0.94043087
57MP0000230_abnormal_systemic_arterial0.93740068
58MP0005551_abnormal_eye_electrophysiolog0.92290956
59MP0005397_hematopoietic_system_phenotyp0.92223205
60MP0001545_abnormal_hematopoietic_system0.92223205
61MP0001299_abnormal_eye_distance/0.91065771
62MP0002168_other_aberrant_phenotype0.90501388
63MP0008932_abnormal_embryonic_tissue0.90334927
64MP0005390_skeleton_phenotype0.89355051
65MP0001485_abnormal_pinna_reflex0.88805849
66MP0003943_abnormal_hepatobiliary_system0.88451814
67MP0003935_abnormal_craniofacial_develop0.87666574
68MP0002751_abnormal_autonomic_nervous0.87462248
69MP0008057_abnormal_DNA_replication0.84976213
70MP0010771_integument_phenotype0.83308171
71MP0002909_abnormal_adrenal_gland0.83145361
72MP0004883_abnormal_blood_vessel0.81262788
73MP0001879_abnormal_lymphatic_vessel0.81199261
74MP0005275_abnormal_skin_tensile0.81057211
75MP0003195_calcinosis0.81038130
76MP0002295_abnormal_pulmonary_circulatio0.80798609
77MP0002116_abnormal_craniofacial_bone0.77685149
78MP0004084_abnormal_cardiac_muscle0.76726205
79MP0005367_renal/urinary_system_phenotyp0.74933506
80MP0000516_abnormal_urinary_system0.74933506
81MP0000383_abnormal_hair_follicle0.74848093
82MP0002085_abnormal_embryonic_tissue0.73797071
83MP0009764_decreased_sensitivity_to0.72914501
84MP0000427_abnormal_hair_cycle0.71808472
85MP0000428_abnormal_craniofacial_morphol0.71003871
86MP0005395_other_phenotype0.70564874
87MP0003718_maternal_effect0.69128666
88MP0005389_reproductive_system_phenotype0.67755113
89MP0000678_abnormal_parathyroid_gland0.66921784
90MP0009745_abnormal_behavioral_response0.66007812
91MP0001440_abnormal_grooming_behavior0.64756604
92MP0002272_abnormal_nervous_system0.62541927
93MP0005257_abnormal_intraocular_pressure0.61213387
94MP0003632_abnormal_nervous_system0.60630626
95MP0003724_increased_susceptibility_to0.60118878
96MP0005501_abnormal_skin_physiology0.59601761
97MP0001533_abnormal_skeleton_physiology0.59571209
98MP0003880_abnormal_central_pattern0.59366559
99MP0002111_abnormal_tail_morphology0.59187844
100MP0005647_abnormal_sex_gland0.58973538

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)4.51460328
2Aplasia/Hypoplasia of the tibia (HP:0005772)4.14109040
3Short tibia (HP:0005736)4.04787918
4Abnormality of incisor morphology (HP:0011063)4.01206602
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.74860120
6Pancreatic fibrosis (HP:0100732)3.73259470
7Aplasia/Hypoplasia of the tongue (HP:0010295)3.72382856
8Tubular atrophy (HP:0000092)3.52828012
9Molar tooth sign on MRI (HP:0002419)3.47502912
10Abnormality of midbrain morphology (HP:0002418)3.47502912
11Entropion (HP:0000621)3.22484650
12Abnormality of dentin (HP:0010299)3.18890165
13Short 1st metacarpal (HP:0010034)3.02120726
14Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.02120726
15Pancreatic cysts (HP:0001737)2.99499552
16Nephronophthisis (HP:0000090)2.92055168
17Mitral valve prolapse (HP:0001634)2.91172392
18Concave nail (HP:0001598)2.89654295
19Cubitus valgus (HP:0002967)2.82567391
20Abnormality of the incisor (HP:0000676)2.77133738
21Hypoproteinemia (HP:0003075)2.76206603
22Arterial tortuosity (HP:0005116)2.63828813
23Increased corneal curvature (HP:0100692)2.62514624
24Keratoconus (HP:0000563)2.62514624
25Aplasia cutis congenita (HP:0001057)2.60531321
26Poikiloderma (HP:0001029)2.57495405
27Abnormality of the 1st metacarpal (HP:0010009)2.54542155
28Fair hair (HP:0002286)2.53873968
29Aortic dissection (HP:0002647)2.52506123
30Vascular tortuosity (HP:0004948)2.49671920
31Peritonitis (HP:0002586)2.47706642
32Narrow forehead (HP:0000341)2.47119607
33Abnormality of the phalanges of the hallux (HP:0010057)2.42670464
34Abnormal umbilical cord blood vessels (HP:0011403)2.42138521
35Single umbilical artery (HP:0001195)2.42138521
36Abnormality of the fetal cardiovascular system (HP:0010948)2.42138521
37Relative macrocephaly (HP:0004482)2.39622285
38Hyperventilation (HP:0002883)2.38547213
39True hermaphroditism (HP:0010459)2.36783378
40Abnormality of the renal medulla (HP:0100957)2.34505416
41Bile duct proliferation (HP:0001408)2.33274803
42Abnormal biliary tract physiology (HP:0012439)2.33274803
43Abnormal number of incisors (HP:0011064)2.27759109
44Type II lissencephaly (HP:0007260)2.26109011
45Curly hair (HP:0002212)2.23775435
46Septo-optic dysplasia (HP:0100842)2.18322629
47Cerebral aneurysm (HP:0004944)2.16051548
48Premature rupture of membranes (HP:0001788)2.15811029
49Asplenia (HP:0001746)2.11810315
50Tubulointerstitial fibrosis (HP:0005576)2.10493762
51Genu recurvatum (HP:0002816)2.08477036
52Optic nerve hypoplasia (HP:0000609)2.05911940
53Soft skin (HP:0000977)2.04500747
54Preauricular skin tag (HP:0000384)2.03052879
55Abnormal drinking behavior (HP:0030082)2.01862604
56Polydipsia (HP:0001959)2.01862604
57Postaxial foot polydactyly (HP:0001830)1.99327816
58Periodontitis (HP:0000704)1.98586846
59Delayed gross motor development (HP:0002194)1.98094488
60Atrophic scars (HP:0001075)1.96011690
61Rhinitis (HP:0012384)1.95952019
62Adrenal hypoplasia (HP:0000835)1.95639801
63Acute lymphatic leukemia (HP:0006721)1.94533597
64Narrow palate (HP:0000189)1.93361212
65Supernumerary spleens (HP:0009799)1.93094438
66Postaxial hand polydactyly (HP:0001162)1.91466332
67Congenital hepatic fibrosis (HP:0002612)1.90112020
68Death in childhood (HP:0003819)1.86983722
69Barrel-shaped chest (HP:0001552)1.86885910
70Long clavicles (HP:0000890)1.85928605
71Irregular vertebral endplates (HP:0003301)1.84679343
72Rectal fistula (HP:0100590)1.83640332
73Rectovaginal fistula (HP:0000143)1.83640332
74Preaxial hand polydactyly (HP:0001177)1.83187965
75Disproportionate short-trunk short stature (HP:0003521)1.82917227
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82778617
77Abnormality of the umbilical cord (HP:0010881)1.80562375
78Action tremor (HP:0002345)1.80447684
79Hypoplasia of the pons (HP:0012110)1.79711097
80Cystic liver disease (HP:0006706)1.78992507
81Occipital encephalocele (HP:0002085)1.78500446
82Osteomalacia (HP:0002749)1.77930064
83Cerebellar dysplasia (HP:0007033)1.77652340
84Medial flaring of the eyebrow (HP:0010747)1.77190077
85Erythroderma (HP:0001019)1.76153034
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.74658643
87Stenosis of the external auditory canal (HP:0000402)1.71821821
88Tubulointerstitial abnormality (HP:0001969)1.71725499
89Sclerocornea (HP:0000647)1.70924731
90Papillary thyroid carcinoma (HP:0002895)1.69837139
91Short phalanx of the thumb (HP:0009660)1.67411340
92Bowel diverticulosis (HP:0005222)1.66976908
93Generalized hypopigmentation of hair (HP:0011358)1.66645435
94Abnormality of the thoracic spine (HP:0100711)1.66069310
95Hyperextensible skin (HP:0000974)1.65987723
96Hypoplastic pelvis (HP:0008839)1.65557059
97Follicular hyperkeratosis (HP:0007502)1.65537979
98Renovascular hypertension (HP:0100817)1.65270531
99Intestinal fistula (HP:0100819)1.64992853
100Cervical subluxation (HP:0003308)1.64231229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK25.68586329
2MAP4K24.85209324
3INSRR4.17889573
4TLK13.31952192
5WNK32.90858075
6BRSK12.82995590
7MARK32.70558025
8TNIK2.60117782
9PTK2B2.41470064
10CCNB12.40075959
11TGFBR22.31985942
12STK242.01693792
13GRK11.89824339
14LIMK11.66029189
15CAMK1D1.62919786
16EPHA31.60521570
17AKT31.55780725
18ADRBK21.42026806
19CHEK21.40646839
20ZAK1.40219905
21CAMK1G1.38702216
22CDC42BPA1.34173102
23MAP3K61.29907550
24MAP3K31.26506871
25PAK31.21144683
26NLK1.13955215
27PRKD21.09313247
28NEK21.06548449
29PKN21.05122986
30DMPK1.02869125
31MAP2K41.02298837
32PTK21.02184326
33FRK1.00104370
34MKNK20.98679388
35PLK30.97013589
36STK30.96662523
37PNCK0.93678451
38LATS20.93078017
39PKN10.90677664
40IRAK30.89401706
41SIK20.86709660
42WNK40.84656442
43FLT30.83227022
44PRKCQ0.82213225
45IRAK10.82192088
46MAPKAPK20.80764850
47MAP3K40.78717834
48MAPKAPK30.78592618
49MAP2K30.77795465
50BRD40.77689304
51DDR20.76130606
52MAP3K120.75341812
53MELK0.74972249
54CASK0.72416798
55STK100.71668416
56STK38L0.69724004
57ADRBK10.67188020
58CHEK10.62936637
59PAK10.61451632
60MOS0.61238223
61PAK20.60112558
62PLK10.59595931
63FGFR10.59389467
64EPHA20.59198405
65BCKDK0.58075441
66PDK20.57127514
67ERBB40.53725474
68GRK50.51289301
69CDK11A0.51099627
70PDGFRB0.49079173
71EPHB10.47734110
72SGK30.47019557
73CDC70.46657481
74ABL20.45809692
75WNK10.45644874
76MAP3K50.44633645
77STK380.43770354
78CAMK2B0.41160053
79PRKCG0.39718908
80MAP2K70.38982296
81NTRK30.36788304
82CDK150.35459252
83SRPK10.35324189
84AURKA0.35135705
85ROCK10.33223554
86AKT10.33141921
87MAPK90.32017219
88INSR0.31035280
89MAP3K90.29982373
90CDK180.29026982
91SGK20.28509135
92ROCK20.27639884
93MAP3K80.27638667
94GSK3B0.26653783
95MAPK80.25815572
96ATM0.25587529
97GRK60.24606138
98CDK120.24362315
99RPS6KA10.23947839
100CDK10.23797827

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.92444169
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.50140085
3Sulfur relay system_Homo sapiens_hsa041223.21250064
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.99144352
5Dorso-ventral axis formation_Homo sapiens_hsa043202.91275840
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.54922915
7Nitrogen metabolism_Homo sapiens_hsa009102.41137700
8Pancreatic secretion_Homo sapiens_hsa049722.34526628
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.26347414
10Linoleic acid metabolism_Homo sapiens_hsa005912.12265731
11Hedgehog signaling pathway_Homo sapiens_hsa043402.09004811
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98856638
13Fat digestion and absorption_Homo sapiens_hsa049751.96288944
14Regulation of autophagy_Homo sapiens_hsa041401.85722910
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80444149
16Protein digestion and absorption_Homo sapiens_hsa049741.79699805
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72337362
18TGF-beta signaling pathway_Homo sapiens_hsa043501.69028034
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.59963937
20Arachidonic acid metabolism_Homo sapiens_hsa005901.53734363
21Fanconi anemia pathway_Homo sapiens_hsa034601.52831875
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50764917
23Selenocompound metabolism_Homo sapiens_hsa004501.39560319
24Phototransduction_Homo sapiens_hsa047441.32347269
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32041337
26Basal transcription factors_Homo sapiens_hsa030221.32007073
27ECM-receptor interaction_Homo sapiens_hsa045121.27025073
28Homologous recombination_Homo sapiens_hsa034401.26609409
29TNF signaling pathway_Homo sapiens_hsa046681.22775492
30Ether lipid metabolism_Homo sapiens_hsa005651.22057028
31Base excision repair_Homo sapiens_hsa034101.16221727
32Hippo signaling pathway_Homo sapiens_hsa043901.12609941
33Basal cell carcinoma_Homo sapiens_hsa052171.11457073
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07773806
35Melanoma_Homo sapiens_hsa052181.05479937
36MAPK signaling pathway_Homo sapiens_hsa040101.03638555
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03314540
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98717006
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97436172
40MicroRNAs in cancer_Homo sapiens_hsa052060.95349593
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95219209
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93199394
43Legionellosis_Homo sapiens_hsa051340.92040249
44Proteoglycans in cancer_Homo sapiens_hsa052050.89432436
45Lysine degradation_Homo sapiens_hsa003100.88790910
46Dilated cardiomyopathy_Homo sapiens_hsa054140.88252917
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.86516735
48Glycerolipid metabolism_Homo sapiens_hsa005610.85321573
49Malaria_Homo sapiens_hsa051440.81494365
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.79184381
51Sphingolipid metabolism_Homo sapiens_hsa006000.78458642
52Protein export_Homo sapiens_hsa030600.78385240
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75173635
54Starch and sucrose metabolism_Homo sapiens_hsa005000.70049475
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69961553
56Pathways in cancer_Homo sapiens_hsa052000.69529567
57Prostate cancer_Homo sapiens_hsa052150.68025332
58Nucleotide excision repair_Homo sapiens_hsa034200.66873786
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66690831
60Amoebiasis_Homo sapiens_hsa051460.64870513
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.63831116
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62589354
63Adherens junction_Homo sapiens_hsa045200.62183368
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60094440
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59786043
66Hepatitis C_Homo sapiens_hsa051600.56604458
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56273384
68Ras signaling pathway_Homo sapiens_hsa040140.53150790
69Ovarian steroidogenesis_Homo sapiens_hsa049130.49541118
70Pertussis_Homo sapiens_hsa051330.49118617
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47868818
72RNA degradation_Homo sapiens_hsa030180.43714092
73Bladder cancer_Homo sapiens_hsa052190.43454381
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43223292
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42713640
76Wnt signaling pathway_Homo sapiens_hsa043100.42695204
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42296649
78FoxO signaling pathway_Homo sapiens_hsa040680.41816504
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41512259
80Focal adhesion_Homo sapiens_hsa045100.41440339
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41018764
82Type II diabetes mellitus_Homo sapiens_hsa049300.39761349
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38870855
84Apoptosis_Homo sapiens_hsa042100.34924040
85Steroid biosynthesis_Homo sapiens_hsa001000.34231806
86HIF-1 signaling pathway_Homo sapiens_hsa040660.34217888
87Nicotine addiction_Homo sapiens_hsa050330.33878507
88Complement and coagulation cascades_Homo sapiens_hsa046100.30690836
89Chemical carcinogenesis_Homo sapiens_hsa052040.30154121
90Olfactory transduction_Homo sapiens_hsa047400.29750646
91Renal cell carcinoma_Homo sapiens_hsa052110.29465000
92Hepatitis B_Homo sapiens_hsa051610.29344438
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28973377
94Melanogenesis_Homo sapiens_hsa049160.28928056
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28847576
96Cell cycle_Homo sapiens_hsa041100.28828723
97Calcium signaling pathway_Homo sapiens_hsa040200.28010433
98Thyroid cancer_Homo sapiens_hsa052160.27076557
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26873407
100Tight junction_Homo sapiens_hsa045300.25880388

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