ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	7.44986762
2	kynurenine metabolic process (GO:0070189)	5.20304047
3	indole-containing compound catabolic process (GO:0042436)	4.70973190
4	indolalkylamine catabolic process (GO:0046218)	4.70973190
5	tryptophan catabolic process (GO:0006569)	4.70973190
6	DNA deamination (GO:0045006)	4.48603003
7	negative regulation of mast cell activation (GO:0033004)	4.44237023
8	regulation of mitotic spindle checkpoint (GO:1903504)	4.27800849
9	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.27800849
10	positive regulation of vasculogenesis (GO:2001214)	4.08473781
11	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.96536943
12	negative regulation of inclusion body assembly (GO:0090084)	3.83649226
13	tryptophan metabolic process (GO:0006568)	3.81009493
14	cell wall macromolecule metabolic process (GO:0044036)	3.71800744
15	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.62217497
16	positive regulation of protein homodimerization activity (GO:0090073)	3.53702351
17	platelet dense granule organization (GO:0060155)	3.52366444
18	negative regulation of membrane potential (GO:0045837)	3.46931991
19	maturation of 5.8S rRNA (GO:0000460)	3.45622828
20	aldehyde catabolic process (GO:0046185)	3.36308753
21	GPI anchor metabolic process (GO:0006505)	3.13789758
22	terpenoid biosynthetic process (GO:0016114)	3.13662101
23	DNA double-strand break processing (GO:0000729)	3.13589256
24	regulation of vasculogenesis (GO:2001212)	3.13423194
25	protein refolding (GO:0042026)	3.12686004
26	carnitine metabolic process (GO:0009437)	3.11028875
27	cellular biogenic amine catabolic process (GO:0042402)	3.10604652
28	amine catabolic process (GO:0009310)	3.10604652
29	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.07389809
30	serotonin receptor signaling pathway (GO:0007210)	3.05924998
31	oxidative phosphorylation (GO:0006119)	3.05860248
32	transcription from mitochondrial promoter (GO:0006390)	3.05272851
33	synaptic transmission, cholinergic (GO:0007271)	3.03213388
34	adenosine metabolic process (GO:0046085)	3.02805655
35	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.99376353
36	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.98738466
37	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.98700103
38	preassembly of GPI anchor in ER membrane (GO:0016254)	2.92533835
39	regulation of heat generation (GO:0031650)	2.89516586
40	positive regulation of prostaglandin secretion (GO:0032308)	2.87623998
41	auditory receptor cell stereocilium organization (GO:0060088)	2.84603137
42	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.82233999
43	cellular response to ATP (GO:0071318)	2.82097505
44	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.80994218
45	indolalkylamine metabolic process (GO:0006586)	2.79069211
46	metallo-sulfur cluster assembly (GO:0031163)	2.78389040
47	iron-sulfur cluster assembly (GO:0016226)	2.78389040
48	sequestering of actin monomers (GO:0042989)	2.77796254
49	rRNA catabolic process (GO:0016075)	2.77339324
50	retinal cone cell development (GO:0046549)	2.76442135
51	positive regulation of defense response to virus by host (GO:0002230)	2.75661257
52	positive regulation of heat generation (GO:0031652)	2.75487108
53	nonmotile primary cilium assembly (GO:0035058)	2.75082291
54	behavioral response to ethanol (GO:0048149)	2.72936113
55	DNA demethylation (GO:0080111)	2.72012643
56	somite rostral/caudal axis specification (GO:0032525)	2.68266836
57	regulation of fever generation (GO:0031620)	2.67980042
58	negative regulation of phagocytosis (GO:0050765)	2.65353341
59	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.64948053
60	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.60866963
61	positive regulation of osteoclast differentiation (GO:0045672)	2.60213669
62	regulation of activation of Janus kinase activity (GO:0010533)	2.55743408
63	negative regulation of interleukin-1 production (GO:0032692)	2.54692375
64	negative regulation of interleukin-1 beta production (GO:0032691)	2.53807049
65	positive regulation of T-helper 1 type immune response (GO:0002827)	2.53486727
66	mannosylation (GO:0097502)	2.53394938
67	neuron fate determination (GO:0048664)	2.52481379
68	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.52354723
69	ATP synthesis coupled proton transport (GO:0015986)	2.52354723
70	benzene-containing compound metabolic process (GO:0042537)	2.51836563
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.51663884
72	negative regulation of T cell differentiation in thymus (GO:0033085)	2.51497634
73	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.51147398
74	pyrimidine nucleobase catabolic process (GO:0006208)	2.51124509
75	regulation of prostaglandin secretion (GO:0032306)	2.50809129
76	regulation of interleukin-8 secretion (GO:2000482)	2.50587998
77	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.50304847
78	protein polyglutamylation (GO:0018095)	2.49540277
79	limb bud formation (GO:0060174)	2.49392944
80	mast cell activation involved in immune response (GO:0002279)	2.49106102
81	mast cell degranulation (GO:0043303)	2.49106102
82	GPI anchor biosynthetic process (GO:0006506)	2.49005417
83	protein complex biogenesis (GO:0070271)	2.47807310
84	cellular response to interleukin-15 (GO:0071350)	2.45918946
85	regulation of glucokinase activity (GO:0033131)	2.45724404
86	regulation of hexokinase activity (GO:1903299)	2.45724404
87	mitochondrial RNA metabolic process (GO:0000959)	2.44804569
88	presynaptic membrane assembly (GO:0097105)	2.44479913
89	isoprenoid biosynthetic process (GO:0008299)	2.43403610
90	amino-acid betaine metabolic process (GO:0006577)	2.42993621
91	DNA dealkylation (GO:0035510)	2.42896044
92	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.42724528
93	positive regulation of histone H3-K4 methylation (GO:0051571)	2.41938403
94	piRNA metabolic process (GO:0034587)	2.41184372
95	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.40124934
96	RNA destabilization (GO:0050779)	2.39613328
97	nucleotide transmembrane transport (GO:1901679)	2.39153709
98	regulation of hypersensitivity (GO:0002883)	2.39141084
99	mitochondrial DNA replication (GO:0006264)	2.37671682
100	indole-containing compound metabolic process (GO:0042430)	2.37090764

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.58236501
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.32996539
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.27904871
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.15759003
5	VDR_22108803_ChIP-Seq_LS180_Human	3.15097650
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00461249
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.99545429
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.81712048
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.81555047
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.76398708
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.59881195
12	EWS_26573619_Chip-Seq_HEK293_Human	2.55082900
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.54543390
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.50782425
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.40354919
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.38051581
17	FUS_26573619_Chip-Seq_HEK293_Human	2.30613970
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.21073399
19	ER_23166858_ChIP-Seq_MCF-7_Human	2.19040741
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.18431532
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17204204
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.15773769
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15196448
24	GBX2_23144817_ChIP-Seq_PC3_Human	2.08603538
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07772928
26	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.94651284
27	P300_19829295_ChIP-Seq_ESCs_Human	1.93877748
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.92317676
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83111057
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.78567516
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74180103
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.63516898
33	AR_20517297_ChIP-Seq_VCAP_Human	1.59593689
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51191715
35	GATA3_26560356_Chip-Seq_TH2_Human	1.50010229
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47605488
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47137303
38	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.39202832
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36085124
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36085124
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35875790
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.35318394
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.33420222
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32767546
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.32767546
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.31134257
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31102691
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31102691
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23083945
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23083945
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21856772
52	NCOR_22424771_ChIP-Seq_293T_Human	1.20470292
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19172957
54	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17613842
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17146388
56	AR_25329375_ChIP-Seq_VCAP_Human	1.16527736
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16324648
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14210623
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13766744
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.12516732
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11474837
62	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10268110
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10204554
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06195519
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04794957
66	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04782178
67	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.04310714
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03952836
69	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.03703946
70	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03061526
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02943684
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02851982
73	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02366770
74	GATA3_26560356_Chip-Seq_TH1_Human	1.01835481
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01323541
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01145431
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01030292
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00917761
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00588207
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99909886
81	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.99843222
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98804734
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98379522
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98359578
85	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.97800110
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97515574
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96830773
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96258383
89	FOXP3_21729870_ChIP-Seq_TREG_Human	0.96164450
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94987768
91	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94188255
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93853510
93	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.92781747
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92267505
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92151408
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91469945
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.90075468
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89597259
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.89499687
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.89394430

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	3.91813937
2	MP0008877_abnormal_DNA_methylation	3.89741623
3	MP0003787_abnormal_imprinting	3.78199228
4	MP0004147_increased_porphyrin_level	3.68875465
5	MP0008875_abnormal_xenobiotic_pharmacok	3.27189894
6	MP0002638_abnormal_pupillary_reflex	3.14892356
7	MP0005167_abnormal_blood-brain_barrier	2.87142746
8	MP0003011_delayed_dark_adaptation	2.62145883
9	MP0005671_abnormal_response_to	2.35392679
10	MP0005084_abnormal_gallbladder_morpholo	2.10019042
11	MP0010386_abnormal_urinary_bladder	2.07969670
12	MP0005253_abnormal_eye_physiology	1.99389027
13	MP0001835_abnormal_antigen_presentation	1.94802158
14	MP0002928_abnormal_bile_duct	1.93617889
15	MP0000685_abnormal_immune_system	1.90780399
16	MP0003252_abnormal_bile_duct	1.90674140
17	MP0005171_absent_coat_pigmentation	1.89324266
18	MP0000538_abnormal_urinary_bladder	1.87439669
19	MP0008058_abnormal_DNA_repair	1.83048691
20	MP0004742_abnormal_vestibular_system	1.82236169
21	MP0005646_abnormal_pituitary_gland	1.74019148
22	MP0002822_catalepsy	1.67707554
23	MP0004885_abnormal_endolymph	1.66241415
24	MP0003724_increased_susceptibility_to	1.60307387
25	MP0003763_abnormal_thymus_physiology	1.57242902
26	MP0005389_reproductive_system_phenotype	1.57219304
27	MP0002138_abnormal_hepatobiliary_system	1.51983094
28	MP0003195_calcinosis	1.47434243
29	MP0009785_altered_susceptibility_to	1.45682084
30	MP0009764_decreased_sensitivity_to	1.42034162
31	MP0002166_altered_tumor_susceptibility	1.39875488
32	MP0001501_abnormal_sleep_pattern	1.39824503
33	MP0008872_abnormal_physiological_respon	1.39808025
34	MP0006292_abnormal_olfactory_placode	1.39440853
35	MP0006276_abnormal_autonomic_nervous	1.39349929
36	MP0004133_heterotaxia	1.37353204
37	MP0009745_abnormal_behavioral_response	1.35511812
38	MP0001800_abnormal_humoral_immune	1.34947594
39	MP0002160_abnormal_reproductive_system	1.32823550
40	MP0001529_abnormal_vocalization	1.30364040
41	MP0001919_abnormal_reproductive_system	1.22836993
42	MP0005387_immune_system_phenotype	1.18209345
43	MP0001790_abnormal_immune_system	1.18209345
44	MP0000372_irregular_coat_pigmentation	1.15572930
45	MP0001986_abnormal_taste_sensitivity	1.14378549
46	MP0002723_abnormal_immune_serum	1.12078673
47	MP0002557_abnormal_social/conspecific_i	1.11825542
48	MP0008961_abnormal_basal_metabolism	1.11234119
49	MP0001486_abnormal_startle_reflex	1.09680760
50	MP0005000_abnormal_immune_tolerance	1.08484971
51	MP0003880_abnormal_central_pattern	1.06823332
52	MP0010329_abnormal_lipoprotein_level	1.06819998
53	MP0003638_abnormal_response/metabolism_	1.05684694
54	MP0002148_abnormal_hypersensitivity_rea	1.05394758
55	MP0004142_abnormal_muscle_tone	1.05093578
56	MP0000465_gastrointestinal_hemorrhage	1.04085232
57	MP0008995_early_reproductive_senescence	1.03468032
58	MP0005551_abnormal_eye_electrophysiolog	1.01747572
59	MP0003866_abnormal_defecation	1.01403033
60	MP0004924_abnormal_behavior	0.99752391
61	MP0005386_behavior/neurological_phenoty	0.99752391
62	MP0001905_abnormal_dopamine_level	0.99203477
63	MP0001440_abnormal_grooming_behavior	0.98305306
64	MP0002272_abnormal_nervous_system	0.96336450
65	MP0002572_abnormal_emotion/affect_behav	0.94879055
66	MP0002006_tumorigenesis	0.94706273
67	MP0003186_abnormal_redox_activity	0.94620198
68	MP0003656_abnormal_erythrocyte_physiolo	0.91464843
69	MP0005365_abnormal_bile_salt	0.91084165
70	MP0004145_abnormal_muscle_electrophysio	0.89564098
71	MP0002938_white_spotting	0.89477056
72	MP0001879_abnormal_lymphatic_vessel	0.89361003
73	MP0001819_abnormal_immune_cell	0.86506814
74	MP0009765_abnormal_xenobiotic_induced	0.86423443
75	MP0000427_abnormal_hair_cycle	0.86176891
76	MP0008775_abnormal_heart_ventricle	0.86036221
77	MP0002420_abnormal_adaptive_immunity	0.85186103
78	MP0002452_abnormal_antigen_presenting	0.84990412
79	MP0001542_abnormal_bone_strength	0.84926110
80	MP0001929_abnormal_gametogenesis	0.83743591
81	MP0001968_abnormal_touch/_nociception	0.81845425
82	MP0001661_extended_life_span	0.80851405
83	MP0005075_abnormal_melanosome_morpholog	0.80246416
84	MP0005085_abnormal_gallbladder_physiolo	0.80035871
85	MP0001485_abnormal_pinna_reflex	0.76090400
86	MP0002736_abnormal_nociception_after	0.75599748
87	MP0009763_increased_sensitivity_to	0.75581798
88	MP0002837_dystrophic_cardiac_calcinosis	0.74745837
89	MP0005391_vision/eye_phenotype	0.74711828
90	MP0010155_abnormal_intestine_physiology	0.73976029
91	MP0000689_abnormal_spleen_morphology	0.73642035
92	MP0000026_abnormal_inner_ear	0.72656479
93	MP0004043_abnormal_pH_regulation	0.71143425
94	MP0000716_abnormal_immune_system	0.70045301
95	MP0004215_abnormal_myocardial_fiber	0.69709162
96	MP0002751_abnormal_autonomic_nervous	0.69027805
97	MP0002722_abnormal_immune_system	0.68474210
98	MP0003136_yellow_coat_color	0.67811002
99	MP0001502_abnormal_circadian_rhythm	0.67205481
100	MP0002282_abnormal_trachea_morphology	0.67056533

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.08933424
2	Abnormality of alanine metabolism (HP:0010916)	4.08933424
3	Hyperalaninemia (HP:0003348)	4.08933424
4	Congenital, generalized hypertrichosis (HP:0004540)	4.07148561
5	Hypoplasia of the uterus (HP:0000013)	3.58938858
6	True hermaphroditism (HP:0010459)	3.54290962
7	Genetic anticipation (HP:0003743)	3.53378934
8	3-Methylglutaconic aciduria (HP:0003535)	3.25772960
9	Stomatitis (HP:0010280)	3.20439000
10	Thyroiditis (HP:0100646)	3.18620677
11	Methylmalonic acidemia (HP:0002912)	3.13491334
12	Congenital sensorineural hearing impairment (HP:0008527)	3.09775536
13	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.06381897
14	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.06381897
15	Aplasia/hypoplasia of the uterus (HP:0008684)	2.97800175
16	Increased hepatocellular lipid droplets (HP:0006565)	2.95290116
17	Severe combined immunodeficiency (HP:0004430)	2.89314363
18	Pancreatic cysts (HP:0001737)	2.83466380
19	Pancreatic fibrosis (HP:0100732)	2.79403855
20	Type II lissencephaly (HP:0007260)	2.76343381
21	Spastic paraparesis (HP:0002313)	2.70856649
22	Congenital stationary night blindness (HP:0007642)	2.64854339
23	Abnormality of midbrain morphology (HP:0002418)	2.63191377
24	Molar tooth sign on MRI (HP:0002419)	2.63191377
25	Lipid accumulation in hepatocytes (HP:0006561)	2.58942180
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.57711589
27	Mitochondrial inheritance (HP:0001427)	2.56317469
28	Elevated erythrocyte sedimentation rate (HP:0003565)	2.52680378
29	Short tibia (HP:0005736)	2.51614742
30	Increased CSF lactate (HP:0002490)	2.49738247
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.47266672
32	Nephronophthisis (HP:0000090)	2.43831417
33	Abnormality of secondary sexual hair (HP:0009888)	2.33458923
34	Abnormality of the axillary hair (HP:0100134)	2.33458923
35	Synostosis involving the elbow (HP:0003938)	2.28822295
36	Humeroradial synostosis (HP:0003041)	2.28822295
37	Acute necrotizing encephalopathy (HP:0006965)	2.25271950
38	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.24023317
39	Abnormality of the aortic arch (HP:0012303)	2.22557938
40	Increased serum pyruvate (HP:0003542)	2.21109648
41	Male pseudohermaphroditism (HP:0000037)	2.19815148
42	Increased serum lactate (HP:0002151)	2.19305145
43	Fibular hypoplasia (HP:0003038)	2.18329926
44	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.15499575
45	Occipital encephalocele (HP:0002085)	2.14351193
46	Methylmalonic aciduria (HP:0012120)	2.12095979
47	Abolished electroretinogram (ERG) (HP:0000550)	2.11740637
48	Homocystinuria (HP:0002156)	2.10766571
49	Abnormality of homocysteine metabolism (HP:0010919)	2.10766571
50	Progressive macrocephaly (HP:0004481)	2.10719414
51	Adactyly (HP:0009776)	2.09124961
52	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.08373812
53	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.06490561
54	Panhypogammaglobulinemia (HP:0003139)	2.04820609
55	Delayed CNS myelination (HP:0002188)	2.04421780
56	Volvulus (HP:0002580)	2.03961043
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.03817800
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.03817800
59	Abnormality of the renal medulla (HP:0100957)	2.03766479
60	IgG deficiency (HP:0004315)	2.00899003
61	Abnormality of the corticospinal tract (HP:0002492)	1.97312346
62	Combined immunodeficiency (HP:0005387)	1.95512015
63	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.94876966
64	Stomach cancer (HP:0012126)	1.91774116
65	Abnormality of the renal cortex (HP:0011035)	1.91581198
66	Rhinitis (HP:0012384)	1.90768600
67	Neoplasm of the adrenal cortex (HP:0100641)	1.90743436
68	Progressive cerebellar ataxia (HP:0002073)	1.89300382
69	Abnormal mitochondria in muscle tissue (HP:0008316)	1.89235568
70	Agammaglobulinemia (HP:0004432)	1.89173655
71	Sclerocornea (HP:0000647)	1.88864760
72	Agitation (HP:0000713)	1.88553330
73	Hypoproteinemia (HP:0003075)	1.88160109
74	Renal Fanconi syndrome (HP:0001994)	1.84317564
75	Large for gestational age (HP:0001520)	1.83821600
76	Lactic acidosis (HP:0003128)	1.83703140
77	Exertional dyspnea (HP:0002875)	1.83672574
78	Morphological abnormality of the pyramidal tract (HP:0002062)	1.83662973
79	Renal cortical cysts (HP:0000803)	1.83408112
80	Pachygyria (HP:0001302)	1.82569351
81	Abnormality of serum amino acid levels (HP:0003112)	1.81942028
82	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.80132751
83	Oligodactyly (HP:0012165)	1.78495175
84	Tetraparesis (HP:0002273)	1.78440610
85	Anorexia (HP:0002039)	1.77571424
86	Brushfield spots (HP:0001088)	1.76808405
87	Brittle hair (HP:0002299)	1.76469904
88	Abnormality of eosinophils (HP:0001879)	1.76036801
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.75660123
90	Broad ribs (HP:0000885)	1.74907259
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73828874
92	Acute encephalopathy (HP:0006846)	1.72357662
93	Absent/shortened dynein arms (HP:0200106)	1.70591022
94	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.70591022
95	Concave nail (HP:0001598)	1.70416973
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.70155216
97	Macular degeneration (HP:0000608)	1.68903144
98	Abnormality of T cell number (HP:0011839)	1.68387998
99	Type 2 muscle fiber atrophy (HP:0003554)	1.68154054
100	Abnormality of glycolysis (HP:0004366)	1.67460977

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.02855915
2	ZAK	3.97703028
3	FRK	3.31969289
4	MUSK	3.15116431
5	TSSK6	2.72674179
6	TLK1	2.46903013
7	INSRR	2.32523908
8	TXK	2.29090109
9	MAP4K2	2.22345602
10	NUAK1	2.20886080
11	RPS6KA4	2.05891488
12	EIF2AK3	1.86213020
13	ERBB3	1.80693529
14	MAPKAPK5	1.74075619
15	GRK6	1.68650881
16	ADRBK2	1.68031289
17	MAP3K14	1.64271839
18	TAOK3	1.63520550
19	MAP2K2	1.62402016
20	FES	1.59479396
21	KDR	1.55876157
22	BMPR1B	1.51826255
23	SIK2	1.50919462
24	SIK3	1.43328427
25	MKNK1	1.40190805
26	VRK1	1.39761456
27	OXSR1	1.33190913
28	TGFBR1	1.32421340
29	PIK3CA	1.26777946
30	MKNK2	1.22718094
31	CAMKK2	1.17653517
32	MAPK13	1.15800912
33	PINK1	1.12947065
34	GRK1	1.09689448
35	DYRK3	1.09247162
36	SYK	1.08945073
37	TEC	1.02437270
38	IKBKB	1.02036054
39	IKBKE	1.01985746
40	TIE1	1.01609473
41	LIMK1	1.01323935
42	EIF2AK1	0.98406476
43	ITK	0.88320645
44	SRPK1	0.87325709
45	CSNK1G2	0.84811264
46	MATK	0.84037480
47	PASK	0.83998699
48	TBK1	0.81828037
49	TESK2	0.78870350
50	STK39	0.78027808
51	VRK2	0.75748323
52	WNK3	0.75697244
53	MAPKAPK3	0.74436912
54	LCK	0.73719153
55	PLK2	0.72783856
56	BTK	0.72643175
57	KIT	0.72152211
58	RPS6KA5	0.71493208
59	MAPK7	0.69793030
60	CDK19	0.67404172
61	ACVR1B	0.67342107
62	FGFR2	0.67047467
63	MAP4K1	0.66947643
64	NEK1	0.66460730
65	PLK3	0.65833026
66	CHUK	0.65788194
67	LYN	0.63730585
68	EIF2AK2	0.63140147
69	TRPM7	0.61493244
70	IGF1R	0.58829643
71	CSNK1G3	0.58043804
72	CAMKK1	0.56272270
73	EGFR	0.55565087
74	CASK	0.55336240
75	TRIM28	0.54159674
76	PHKG2	0.53261020
77	PHKG1	0.53261020
78	FER	0.52991504
79	PRKCE	0.52661632
80	CSNK1A1L	0.52462601
81	ABL1	0.51615832
82	ADRBK1	0.51354190
83	PNCK	0.47875043
84	BCR	0.46357665
85	DDR2	0.43804184
86	PKN1	0.43532000
87	CCNB1	0.41933852
88	FLT3	0.41667046
89	PRKCQ	0.40564716
90	JAK3	0.40021478
91	PRKG1	0.34400544
92	CAMK4	0.33904134
93	OBSCN	0.33534517
94	STK38L	0.33135691
95	HCK	0.31830706
96	CHEK2	0.31739179
97	PAK6	0.31381799
98	MAPK4	0.31257357
99	CAMK2A	0.31250438
100	DAPK2	0.31145738

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	5.82601902
2	Asthma_Homo sapiens_hsa05310	3.43552021
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.75180065
4	Allograft rejection_Homo sapiens_hsa05330	2.38581327
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.28734675
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.26862990
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.13757759
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.06740462
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.01685014
10	Type I diabetes mellitus_Homo sapiens_hsa04940	1.99027836
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91900635
12	Butanoate metabolism_Homo sapiens_hsa00650	1.90382614
13	Proteasome_Homo sapiens_hsa03050	1.84159120
14	Sulfur metabolism_Homo sapiens_hsa00920	1.82817904
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82417113
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.80238486
17	Protein export_Homo sapiens_hsa03060	1.75587263
18	Parkinsons disease_Homo sapiens_hsa05012	1.70941043
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70492371
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.66923982
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65557397
22	Phototransduction_Homo sapiens_hsa04744	1.64488666
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64278728
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.62180759
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.61089932
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56922791
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.54001581
28	Olfactory transduction_Homo sapiens_hsa04740	1.45459724
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.44910144
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.39635352
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32112840
32	Peroxisome_Homo sapiens_hsa04146	1.20620056
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.17672915
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15829566
35	Ribosome_Homo sapiens_hsa03010	1.14711750
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.12280700
37	Spliceosome_Homo sapiens_hsa03040	1.10337694
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.09539268
39	Leishmaniasis_Homo sapiens_hsa05140	1.05432476
40	Basal transcription factors_Homo sapiens_hsa03022	1.04233791
41	Nicotine addiction_Homo sapiens_hsa05033	1.02464852
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01583181
43	RNA polymerase_Homo sapiens_hsa03020	0.98010950
44	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.96060029
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.94160049
46	RNA degradation_Homo sapiens_hsa03018	0.90325062
47	Huntingtons disease_Homo sapiens_hsa05016	0.88773032
48	Taste transduction_Homo sapiens_hsa04742	0.87668203
49	Alzheimers disease_Homo sapiens_hsa05010	0.86277006
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84734095
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83911818
52	Retinol metabolism_Homo sapiens_hsa00830	0.83541037
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82604037
54	Circadian rhythm_Homo sapiens_hsa04710	0.79446627
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79098201
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77066007
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75725407
58	Regulation of autophagy_Homo sapiens_hsa04140	0.75319199
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75310032
60	Homologous recombination_Homo sapiens_hsa03440	0.73836674
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.72921154
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.71970113
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71436888
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71195848
65	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.70587348
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70226891
67	Legionellosis_Homo sapiens_hsa05134	0.69351467
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68178380
69	Morphine addiction_Homo sapiens_hsa05032	0.67467498
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.64498703
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60964253
72	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.60433420
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57454504
74	Herpes simplex infection_Homo sapiens_hsa05168	0.57058548
75	One carbon pool by folate_Homo sapiens_hsa00670	0.56181973
76	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55790525
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55171896
78	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.53785200
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53193786
80	Serotonergic synapse_Homo sapiens_hsa04726	0.50661140
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49594336
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49218451
83	Viral myocarditis_Homo sapiens_hsa05416	0.46515712
84	Propanoate metabolism_Homo sapiens_hsa00640	0.41118091
85	Metabolic pathways_Homo sapiens_hsa01100	0.39629965
86	Purine metabolism_Homo sapiens_hsa00230	0.34513802
87	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.34191265
88	Shigellosis_Homo sapiens_hsa05131	0.33233274
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33088108
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32501898
91	GABAergic synapse_Homo sapiens_hsa04727	0.31664138
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29044349
93	Salivary secretion_Homo sapiens_hsa04970	0.28707483
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27253417
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.26162442
96	Malaria_Homo sapiens_hsa05144	0.26129723
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26100034
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.25905132
99	Non-homologous end-joining_Homo sapiens_hsa03450	0.24707396
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24280207

HMGN1P35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »