HMGN1P36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.42360150
2translational termination (GO:0006415)6.13296484
3response to pheromone (GO:0019236)5.87390676
4cotranslational protein targeting to membrane (GO:0006613)5.22107982
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.05210107
6protein targeting to ER (GO:0045047)5.04164996
7somite development (GO:0061053)4.97193549
8sequestering of actin monomers (GO:0042989)4.93631110
9establishment of protein localization to endoplasmic reticulum (GO:0072599)4.79365442
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.66652446
11translational elongation (GO:0006414)4.65551378
12protein localization to endoplasmic reticulum (GO:0070972)4.62055955
13cellular protein complex disassembly (GO:0043624)4.60999362
14ribosomal small subunit biogenesis (GO:0042274)4.57448939
15dopaminergic neuron differentiation (GO:0071542)4.55232553
16viral life cycle (GO:0019058)4.52118330
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.50706548
18diacylglycerol metabolic process (GO:0046339)4.46390324
19midbrain development (GO:0030901)4.41665206
20primitive streak formation (GO:0090009)4.24927278
21urogenital system development (GO:0001655)4.22756711
22otic vesicle formation (GO:0030916)4.19963439
23adult feeding behavior (GO:0008343)4.02209040
24positive regulation of gastrulation (GO:2000543)3.94872234
25protein complex disassembly (GO:0043241)3.90061955
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.89931085
27artery smooth muscle contraction (GO:0014824)3.86276100
28heme transport (GO:0015886)3.85203412
29macromolecular complex disassembly (GO:0032984)3.66205645
30positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.62403352
31translational initiation (GO:0006413)3.60478518
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58896282
33ribosomal small subunit assembly (GO:0000028)3.54935848
34hindbrain development (GO:0030902)3.54884010
35intestinal epithelial cell development (GO:0060576)3.53651611
36spinal cord development (GO:0021510)3.43376786
37protein targeting to membrane (GO:0006612)3.41216450
38neuronal stem cell maintenance (GO:0097150)3.37791248
39histone H2A monoubiquitination (GO:0035518)3.35508186
40tonic smooth muscle contraction (GO:0014820)3.27690396
41thalamus development (GO:0021794)3.26061294
42ATP synthesis coupled proton transport (GO:0015986)3.19532295
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19532295
44respiratory chain complex IV assembly (GO:0008535)3.10711349
45regulation of feeding behavior (GO:0060259)3.10700621
46embryonic foregut morphogenesis (GO:0048617)3.09721726
47sulfation (GO:0051923)3.08925711
48regulation of hexokinase activity (GO:1903299)3.08335938
49regulation of glucokinase activity (GO:0033131)3.08335938
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.05908204
51neuron fate determination (GO:0048664)3.04872062
52limb bud formation (GO:0060174)3.04254890
53response to folic acid (GO:0051593)3.02999734
54dendritic spine morphogenesis (GO:0060997)3.02629769
55establishment of planar polarity (GO:0001736)2.97868269
56establishment of tissue polarity (GO:0007164)2.97868269
57G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.96667659
58iron coordination entity transport (GO:1901678)2.95251231
59somite rostral/caudal axis specification (GO:0032525)2.94252417
60DNA damage response, detection of DNA damage (GO:0042769)2.94101549
61pyrimidine nucleobase catabolic process (GO:0006208)2.90903209
62mRNA catabolic process (GO:0006402)2.90625830
63retinal ganglion cell axon guidance (GO:0031290)2.87551090
64neural crest cell development (GO:0014032)2.87219628
65renal system development (GO:0072001)2.86124017
66behavioral response to nicotine (GO:0035095)2.85294947
67positive regulation of odontogenesis (GO:0042482)2.84944480
68regulation of glycogen (starch) synthase activity (GO:2000465)2.83827242
69seminiferous tubule development (GO:0072520)2.82897539
70protein polyglutamylation (GO:0018095)2.82369954
71forebrain neuron differentiation (GO:0021879)2.81862913
72glycerol metabolic process (GO:0006071)2.79773131
73negative regulation of leukocyte chemotaxis (GO:0002689)2.79280109
74positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.78592305
75ventricular septum morphogenesis (GO:0060412)2.67574089
76regulation of cGMP metabolic process (GO:0030823)2.67463645
77nephron epithelium morphogenesis (GO:0072088)2.67376611
78nephron tubule morphogenesis (GO:0072078)2.67376611
79pancreas development (GO:0031016)2.67088689
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.65625010
81regulation of translation, ncRNA-mediated (GO:0045974)2.65625010
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65625010
83epithelial cilium movement (GO:0003351)2.64875191
84regulation of vasculogenesis (GO:2001212)2.64846958
85urate metabolic process (GO:0046415)2.63106545
86maturation of SSU-rRNA (GO:0030490)2.63100152
87phospholipid homeostasis (GO:0055091)2.60048630
88negative regulation of inclusion body assembly (GO:0090084)2.59966001
89positive regulation of vasculogenesis (GO:2001214)2.59295662
90pericardium development (GO:0060039)2.59240195
91pituitary gland development (GO:0021983)2.58975899
92positive regulation of cGMP metabolic process (GO:0030825)2.58958462
93positive regulation of cGMP biosynthetic process (GO:0030828)2.58353569
94dorsal/ventral neural tube patterning (GO:0021904)2.57484511
95auditory behavior (GO:0031223)2.56777289
96epithelial tube branching involved in lung morphogenesis (GO:0060441)2.54785173
97regulation of mesoderm development (GO:2000380)2.53865052
98high-density lipoprotein particle remodeling (GO:0034375)2.53690303
99regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53448708
100vascular smooth muscle contraction (GO:0014829)2.52463763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.85508027
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.62095110
3CBX2_27304074_Chip-Seq_ESCs_Mouse3.07389308
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.96796388
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.68937505
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.63970732
7TAF15_26573619_Chip-Seq_HEK293_Human2.57161933
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.52422181
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47097019
10ZNF274_21170338_ChIP-Seq_K562_Hela2.45242167
11FUS_26573619_Chip-Seq_HEK293_Human2.44707971
12VDR_22108803_ChIP-Seq_LS180_Human2.41039220
13RNF2_27304074_Chip-Seq_NSC_Mouse2.38702894
14EWS_26573619_Chip-Seq_HEK293_Human2.25579794
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24899907
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24706826
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24324654
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20683773
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18011338
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.14566016
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11725576
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01449367
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99392441
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96711584
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.88410446
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88410446
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88181117
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87518445
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87518445
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86821343
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.85685095
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.85442191
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83304948
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77738915
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75949369
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.71478852
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.66068986
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65467642
39REST_21632747_ChIP-Seq_MESCs_Mouse1.62190954
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62137167
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62129273
42MYC_18940864_ChIP-ChIP_HL60_Human1.61986994
43IRF1_19129219_ChIP-ChIP_H3396_Human1.53250523
44KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.46772052
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45908621
46P300_19829295_ChIP-Seq_ESCs_Human1.44666456
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44051370
48AR_21572438_ChIP-Seq_LNCaP_Human1.43862337
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.43680032
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.43524300
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42596874
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.39186822
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.38839726
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38225790
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.37665444
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35017170
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33986890
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32245774
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31372187
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29951169
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.27144823
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.25725967
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.24644456
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23552712
65TP53_22573176_ChIP-Seq_HFKS_Human1.22402353
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.21542060
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20878028
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20600791
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19465711
70AR_25329375_ChIP-Seq_VCAP_Human1.18934051
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18113591
72BCAT_22108803_ChIP-Seq_LS180_Human1.16187868
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15733607
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15550145
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14190051
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13346789
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13174362
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12874411
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12864358
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12667906
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.12568061
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10323057
83GBX2_23144817_ChIP-Seq_PC3_Human1.09333387
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07760776
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07097026
86ELK1_19687146_ChIP-ChIP_HELA_Human1.05974689
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04398146
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04299261
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03190098
90RUNX2_22187159_ChIP-Seq_PCA_Human1.03097566
91TP53_18474530_ChIP-ChIP_U2OS_Human1.02671692
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02435369
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01306520
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00256921
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00199202
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.98082709
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95358379
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93542687
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.93151728
100SMAD4_21799915_ChIP-Seq_A2780_Human0.92704521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.49658708
2MP0003283_abnormal_digestive_organ4.35745266
3MP0001986_abnormal_taste_sensitivity4.27869196
4MP0009379_abnormal_foot_pigmentation4.20881901
5MP0006292_abnormal_olfactory_placode4.12046372
6MP0000569_abnormal_digit_pigmentation3.82608177
7MP0004147_increased_porphyrin_level3.54915890
8MP0002277_abnormal_respiratory_mucosa2.97572648
9MP0000566_synostosis2.68687182
10MP0002938_white_spotting2.37218962
11MP0005085_abnormal_gallbladder_physiolo2.32740561
12MP0005187_abnormal_penis_morphology2.26467551
13MP0003880_abnormal_central_pattern2.11143693
14MP0006276_abnormal_autonomic_nervous2.09086131
15MP0003890_abnormal_embryonic-extraembry2.05801725
16MP0005084_abnormal_gallbladder_morpholo2.04788631
17MP0001293_anophthalmia2.03602837
18MP0003119_abnormal_digestive_system1.94131798
19MP0000462_abnormal_digestive_system1.93351609
20MP0002822_catalepsy1.84342642
21MP0001346_abnormal_lacrimal_gland1.76618216
22MP0001879_abnormal_lymphatic_vessel1.76305431
23MP0004133_heterotaxia1.72454269
24MP0000778_abnormal_nervous_system1.70002088
25MP0004142_abnormal_muscle_tone1.66674341
26MP0000631_abnormal_neuroendocrine_gland1.63785369
27MP0009697_abnormal_copulation1.62411796
28MP0003315_abnormal_perineum_morphology1.59104149
29MP0006072_abnormal_retinal_apoptosis1.56264491
30MP0002735_abnormal_chemical_nociception1.49609428
31MP0003011_delayed_dark_adaptation1.49564823
32MP0001299_abnormal_eye_distance/1.48840233
33MP0000372_irregular_coat_pigmentation1.48554206
34MP0000049_abnormal_middle_ear1.41003236
35MP0003959_abnormal_lean_body1.38346159
36MP0001286_abnormal_eye_development1.33705774
37MP0002736_abnormal_nociception_after1.31812717
38MP0001661_extended_life_span1.28166535
39MP0008961_abnormal_basal_metabolism1.23171419
40MP0001529_abnormal_vocalization1.21511415
41MP0002697_abnormal_eye_size1.20310731
42MP0005167_abnormal_blood-brain_barrier1.16352096
43MP0003938_abnormal_ear_development1.11724376
44MP0010030_abnormal_orbit_morphology1.11080924
45MP0002928_abnormal_bile_duct1.10507331
46MP0003878_abnormal_ear_physiology1.09450700
47MP0005377_hearing/vestibular/ear_phenot1.09450700
48MP0000537_abnormal_urethra_morphology1.09233281
49MP0003121_genomic_imprinting1.07681989
50MP0002282_abnormal_trachea_morphology1.06170695
51MP0003122_maternal_imprinting1.05480562
52MP0005391_vision/eye_phenotype1.03095707
53MP0002733_abnormal_thermal_nociception1.02382862
54MP0001485_abnormal_pinna_reflex1.01625606
55MP0005551_abnormal_eye_electrophysiolog0.99593652
56MP0005253_abnormal_eye_physiology0.97496821
57MP0001968_abnormal_touch/_nociception0.97247409
58MP0000026_abnormal_inner_ear0.95555923
59MP0002638_abnormal_pupillary_reflex0.95052183
60MP0003123_paternal_imprinting0.94303015
61MP0003937_abnormal_limbs/digits/tail_de0.92808126
62MP0002092_abnormal_eye_morphology0.91897516
63MP0002751_abnormal_autonomic_nervous0.91303888
64MP0002234_abnormal_pharynx_morphology0.91288557
65MP0005171_absent_coat_pigmentation0.90215041
66MP0002557_abnormal_social/conspecific_i0.89927409
67MP0002102_abnormal_ear_morphology0.89620907
68MP0002067_abnormal_sensory_capabilities0.88595087
69MP0001905_abnormal_dopamine_level0.88461025
70MP0000762_abnormal_tongue_morphology0.85562325
71MP0000516_abnormal_urinary_system0.84726286
72MP0005367_renal/urinary_system_phenotyp0.84726286
73MP0003137_abnormal_impulse_conducting0.84408424
74MP0002734_abnormal_mechanical_nocicepti0.82482916
75MP0009745_abnormal_behavioral_response0.82346482
76MP0004885_abnormal_endolymph0.81671980
77MP0004742_abnormal_vestibular_system0.80472993
78MP0005195_abnormal_posterior_eye0.80365084
79MP0002572_abnormal_emotion/affect_behav0.79793106
80MP0003693_abnormal_embryo_hatching0.77438134
81MP0003755_abnormal_palate_morphology0.75963309
82MP0002116_abnormal_craniofacial_bone0.75563723
83MP0009250_abnormal_appendicular_skeleto0.75559961
84MP0003718_maternal_effect0.73882219
85MP0001970_abnormal_pain_threshold0.72291286
86MP0009053_abnormal_anal_canal0.72220706
87MP0005423_abnormal_somatic_nervous0.71413635
88MP0002752_abnormal_somatic_nervous0.71176572
89MP0003935_abnormal_craniofacial_develop0.69765098
90MP0005535_abnormal_body_temperature0.69740925
91MP0003638_abnormal_response/metabolism_0.69286861
92MP0002272_abnormal_nervous_system0.66563966
93MP0000383_abnormal_hair_follicle0.66558826
94MP0002233_abnormal_nose_morphology0.66533406
95MP0004215_abnormal_myocardial_fiber0.64980449
96MP0001324_abnormal_eye_pigmentation0.63762109
97MP0003861_abnormal_nervous_system0.61043927
98MP0002111_abnormal_tail_morphology0.60155072
99MP0002653_abnormal_ependyma_morphology0.60119982
100MP0002152_abnormal_brain_morphology0.59568726

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.42396785
2Congenital, generalized hypertrichosis (HP:0004540)4.15133742
3Reticulocytopenia (HP:0001896)4.05388171
4Chronic hepatic failure (HP:0100626)3.96660569
5Nephronophthisis (HP:0000090)3.83351844
6Abnormality of midbrain morphology (HP:0002418)3.75503168
7Molar tooth sign on MRI (HP:0002419)3.75503168
8Hyperlipoproteinemia (HP:0010980)3.70022470
9Maternal diabetes (HP:0009800)3.41795979
10Supernumerary bones of the axial skeleton (HP:0009144)3.38092121
11Delayed CNS myelination (HP:0002188)3.32685160
12Concave nail (HP:0001598)3.30007183
13Optic nerve hypoplasia (HP:0000609)3.27875587
14Supernumerary ribs (HP:0005815)3.26173246
15Stenosis of the external auditory canal (HP:0000402)3.25793785
16Abnormal number of incisors (HP:0011064)3.25366648
17Abnormality of the renal medulla (HP:0100957)3.13046572
18True hermaphroditism (HP:0010459)3.03532827
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92594217
20Short 4th metacarpal (HP:0010044)2.92594217
21Esophageal atresia (HP:0002032)2.90304344
22Medial flaring of the eyebrow (HP:0010747)2.85904231
23Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.82918154
24Supernumerary spleens (HP:0009799)2.80519045
25Macrocytic anemia (HP:0001972)2.79187183
26Absent septum pellucidum (HP:0001331)2.77465731
27Pendular nystagmus (HP:0012043)2.74239715
28Abnormality of the 4th metacarpal (HP:0010012)2.73289009
29Increased hepatocellular lipid droplets (HP:0006565)2.71654186
30Pancreatic cysts (HP:0001737)2.70984894
31Abnormality of the septum pellucidum (HP:0007375)2.66187583
32Abnormality of cells of the erythroid lineage (HP:0012130)2.59370760
33Intestinal atresia (HP:0011100)2.57990626
34Abnormal number of erythroid precursors (HP:0012131)2.57939114
35Pancreatic fibrosis (HP:0100732)2.57273264
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.52738433
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52738433
38Renal Fanconi syndrome (HP:0001994)2.46543114
39Decreased central vision (HP:0007663)2.46492944
40Anophthalmia (HP:0000528)2.45439331
41Congenital hepatic fibrosis (HP:0002612)2.43930699
42Abnormality of the axillary hair (HP:0100134)2.42816136
43Abnormality of secondary sexual hair (HP:0009888)2.42816136
44Abnormality of the parietal bone (HP:0002696)2.40983526
45Gastrointestinal atresia (HP:0002589)2.39000515
463-Methylglutaconic aciduria (HP:0003535)2.37897113
47Abnormality of the lower motor neuron (HP:0002366)2.34121638
48Tubular atrophy (HP:0000092)2.33071394
49Bilateral microphthalmos (HP:0007633)2.31669827
50Down-sloping shoulders (HP:0200021)2.30352020
51Oligodactyly (hands) (HP:0001180)2.29979203
52Occipital encephalocele (HP:0002085)2.22161488
53Optic nerve coloboma (HP:0000588)2.20447750
54Anencephaly (HP:0002323)2.18152493
55Sclerocornea (HP:0000647)2.16000179
56Stomach cancer (HP:0012126)2.15643776
57Hepatocellular necrosis (HP:0001404)2.13644355
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13258889
59Abnormality of renal resorption (HP:0011038)2.11415823
60Bile duct proliferation (HP:0001408)2.10393019
61Abnormal biliary tract physiology (HP:0012439)2.10393019
62Anterior segment dysgenesis (HP:0007700)2.07835332
63Lipid accumulation in hepatocytes (HP:0006561)2.07478391
64Woolly hair (HP:0002224)2.06108922
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.04205149
66Neoplasm of the heart (HP:0100544)2.03866206
67Hemivertebrae (HP:0002937)2.03436987
68Pallor (HP:0000980)2.03204368
69Short hallux (HP:0010109)2.02882272
70Congenital stationary night blindness (HP:0007642)2.00638235
71Intellectual disability, moderate (HP:0002342)1.98867037
72Mitochondrial inheritance (HP:0001427)1.97293806
73Abnormality of the phalanges of the 2nd finger (HP:0009541)1.97051376
74Aplasia/Hypoplasia of the hallux (HP:0008362)1.92479087
75Preaxial foot polydactyly (HP:0001841)1.91094892
76Gait imbalance (HP:0002141)1.91067562
77Absent speech (HP:0001344)1.88453137
78Hypoplasia of the pons (HP:0012110)1.87898598
79Abnormality of the diencephalon (HP:0010662)1.87387195
80Optic disc pallor (HP:0000543)1.85615445
81Depressed nasal ridge (HP:0000457)1.83738195
82Cystic liver disease (HP:0006706)1.83696193
83Abnormality of the labia minora (HP:0012880)1.82831075
84Focal motor seizures (HP:0011153)1.80187836
85Tubulointerstitial fibrosis (HP:0005576)1.78810064
86Congenital primary aphakia (HP:0007707)1.78378805
87Growth hormone deficiency (HP:0000824)1.76749689
88Patellar aplasia (HP:0006443)1.75477066
89Severe visual impairment (HP:0001141)1.74664938
90Amblyopia (HP:0000646)1.73134405
91Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71772278
92Neoplasm of the oral cavity (HP:0100649)1.71729024
93Gonadotropin excess (HP:0000837)1.70925567
94Cerebellar dysplasia (HP:0007033)1.70526243
95Exertional dyspnea (HP:0002875)1.70248620
96Male pseudohermaphroditism (HP:0000037)1.67867716
97Abnormality of the corticospinal tract (HP:0002492)1.65996076
98Genu varum (HP:0002970)1.64993659
99Enlarged penis (HP:0000040)1.63416544
100Hepatic necrosis (HP:0002605)1.62997353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.10018863
2BMPR1B3.76511690
3CASK3.75171252
4WEE13.16996424
5EPHB22.87604629
6EPHA42.83269556
7TIE12.73390209
8TNIK2.66288257
9TGFBR12.39988285
10ACVR1B2.36167947
11TSSK62.32682332
12ZAK2.30224733
13TLK12.22664313
14NTRK32.18473865
15SRPK12.18131422
16MAPK152.13043679
17WNK32.05712626
18CDC71.70032178
19VRK11.58356046
20PINK11.55673941
21DYRK31.49872627
22DYRK21.49173327
23TESK21.32994216
24NEK21.32584192
25ABL21.20666912
26MAP3K41.20056061
27WNK41.20007835
28MAPK131.17505545
29AKT31.11444274
30STK391.11232558
31CDK31.10767312
32MARK11.10108229
33ADRBK21.07371900
34UHMK11.07260555
35STK31.07208660
36PRKCG1.03808149
37PASK0.99184752
38GRK10.95943625
39PLK30.94098922
40ADRBK10.92636064
41CDK80.91269142
42NTRK20.83392589
43CHUK0.79067116
44PIM10.73721953
45MAPKAPK50.72114913
46MAP2K70.71254407
47FGFR20.70008796
48STK38L0.69620186
49LATS10.62027026
50PAK30.61199487
51INSRR0.61074168
52MAP2K40.60889096
53MAPK70.59792211
54IRAK20.57525258
55MAP2K10.56483867
56NEK10.56422988
57BUB10.55774140
58FGFR10.55264299
59RPS6KA60.53442644
60MAP3K100.51920379
61VRK20.50636992
62PRKCE0.49497540
63OXSR10.49077933
64KDR0.47577977
65AURKA0.46011644
66CDK120.44321826
67OBSCN0.41704394
68MINK10.41331245
69PRKACB0.40983808
70MKNK10.39583127
71CSNK1G20.37619455
72ERBB20.35838136
73AURKB0.35529101
74BCKDK0.34238860
75CAMK1G0.33806845
76NLK0.33748670
77CHEK20.33586472
78PRKG10.32270996
79RPS6KA40.30370711
80IKBKB0.30107669
81CSNK2A10.29554397
82PRKACA0.28830841
83IRAK10.28413721
84FRK0.27400338
85PRKCH0.26540558
86HIPK20.25116536
87TTK0.24961657
88CDK90.23697855
89SGK10.23673128
90ATR0.23317720
91PTK2B0.23277644
92BCR0.22911695
93PLK10.22817597
94SGK20.22708263
95RPS6KA50.22468268
96CAMK2A0.22241586
97CSNK2A20.21445396
98MAP3K20.20899218
99CSNK1E0.20167823
100NUAK10.19908291

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.00779524
2Caffeine metabolism_Homo sapiens_hsa002323.78386161
3Oxidative phosphorylation_Homo sapiens_hsa001903.42453736
4Parkinsons disease_Homo sapiens_hsa050122.92882247
5Basal cell carcinoma_Homo sapiens_hsa052172.57478610
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.45036458
7Linoleic acid metabolism_Homo sapiens_hsa005912.26592808
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.22640109
9Cardiac muscle contraction_Homo sapiens_hsa042602.16204022
10Nicotine addiction_Homo sapiens_hsa050332.09107319
11Nitrogen metabolism_Homo sapiens_hsa009101.97431030
12Phototransduction_Homo sapiens_hsa047441.94273870
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88505580
14Alzheimers disease_Homo sapiens_hsa050101.88351128
15Huntingtons disease_Homo sapiens_hsa050161.85052163
16Selenocompound metabolism_Homo sapiens_hsa004501.67800579
17Protein export_Homo sapiens_hsa030601.66592687
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61534124
19Basal transcription factors_Homo sapiens_hsa030221.58494512
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50746191
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48333396
22Hedgehog signaling pathway_Homo sapiens_hsa043401.47650418
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44975196
24Homologous recombination_Homo sapiens_hsa034401.35472572
25Dorso-ventral axis formation_Homo sapiens_hsa043201.31577493
26Chemical carcinogenesis_Homo sapiens_hsa052041.28665270
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27484334
28Ovarian steroidogenesis_Homo sapiens_hsa049131.26267893
29Bile secretion_Homo sapiens_hsa049761.25251318
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20036622
31Glycerolipid metabolism_Homo sapiens_hsa005611.17026463
32Hippo signaling pathway_Homo sapiens_hsa043901.16205692
33RNA polymerase_Homo sapiens_hsa030201.12603611
34Vitamin digestion and absorption_Homo sapiens_hsa049771.10572007
35Taste transduction_Homo sapiens_hsa047421.09532719
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04634104
37Axon guidance_Homo sapiens_hsa043601.03915134
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.00941307
39Insulin secretion_Homo sapiens_hsa049110.99601595
40Olfactory transduction_Homo sapiens_hsa047400.98703053
41Fanconi anemia pathway_Homo sapiens_hsa034600.97435985
42Glutamatergic synapse_Homo sapiens_hsa047240.97155441
43Cocaine addiction_Homo sapiens_hsa050300.96466838
44GABAergic synapse_Homo sapiens_hsa047270.95489612
45ABC transporters_Homo sapiens_hsa020100.91747007
46Spliceosome_Homo sapiens_hsa030400.84292166
47Arachidonic acid metabolism_Homo sapiens_hsa005900.83461368
48TGF-beta signaling pathway_Homo sapiens_hsa043500.82003984
49Tight junction_Homo sapiens_hsa045300.81593632
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81039337
51RNA degradation_Homo sapiens_hsa030180.80561199
52Wnt signaling pathway_Homo sapiens_hsa043100.78170246
53Circadian entrainment_Homo sapiens_hsa047130.77976173
54Melanogenesis_Homo sapiens_hsa049160.77515158
55Morphine addiction_Homo sapiens_hsa050320.77095049
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75016542
57Serotonergic synapse_Homo sapiens_hsa047260.74732731
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72632587
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70530311
60Gap junction_Homo sapiens_hsa045400.63825327
61Long-term depression_Homo sapiens_hsa047300.63589683
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63438183
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59051161
64cAMP signaling pathway_Homo sapiens_hsa040240.58516093
65Tryptophan metabolism_Homo sapiens_hsa003800.55312478
66Retinol metabolism_Homo sapiens_hsa008300.54959611
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54304836
68Notch signaling pathway_Homo sapiens_hsa043300.53873737
69Histidine metabolism_Homo sapiens_hsa003400.52975929
70Sulfur metabolism_Homo sapiens_hsa009200.50582031
71Collecting duct acid secretion_Homo sapiens_hsa049660.50419249
72Complement and coagulation cascades_Homo sapiens_hsa046100.49204283
73Glutathione metabolism_Homo sapiens_hsa004800.48625506
74Nucleotide excision repair_Homo sapiens_hsa034200.48577415
75Mineral absorption_Homo sapiens_hsa049780.44669586
76Calcium signaling pathway_Homo sapiens_hsa040200.43486410
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43178435
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.40170802
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39098027
80Butanoate metabolism_Homo sapiens_hsa006500.37739048
81Cholinergic synapse_Homo sapiens_hsa047250.35940326
82Protein digestion and absorption_Homo sapiens_hsa049740.35803399
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35623093
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.33788765
85Pathways in cancer_Homo sapiens_hsa052000.33626213
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32781672
87Folate biosynthesis_Homo sapiens_hsa007900.32284011
88Peroxisome_Homo sapiens_hsa041460.31718738
89Proteasome_Homo sapiens_hsa030500.31686692
90Amphetamine addiction_Homo sapiens_hsa050310.30934147
91Purine metabolism_Homo sapiens_hsa002300.30430625
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30202397
93Non-homologous end-joining_Homo sapiens_hsa034500.28657589
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28133384
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27616240
96ECM-receptor interaction_Homo sapiens_hsa045120.27338457
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.26373703
98Regulation of autophagy_Homo sapiens_hsa041400.24974057
99Ether lipid metabolism_Homo sapiens_hsa005650.23815466
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23133733

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