ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	7.50927521
2	protein neddylation (GO:0045116)	4.90065027
3	heterochromatin organization (GO:0070828)	4.71059893
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.53005993
5	chaperone-mediated protein transport (GO:0072321)	4.34639812
6	outer ear morphogenesis (GO:0042473)	4.28803785
7	ATP synthesis coupled proton transport (GO:0015986)	4.17747396
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.17747396
9	base-excision repair, AP site formation (GO:0006285)	4.03839371
10	monocyte chemotaxis (GO:0002548)	3.94430928
11	regulation of mitochondrial translation (GO:0070129)	3.92867627
12	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.79850034
13	axoneme assembly (GO:0035082)	3.64323395
14	ribosomal small subunit biogenesis (GO:0042274)	3.61020597
15	regulation of mitotic spindle organization (GO:0060236)	3.59821950
16	replication fork processing (GO:0031297)	3.54039767
17	termination of RNA polymerase III transcription (GO:0006386)	3.48362797
18	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.48362797
19	viral transcription (GO:0019083)	3.38870560
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.34596173
21	electron transport chain (GO:0022900)	3.34021902
22	respiratory electron transport chain (GO:0022904)	3.32253797
23	interkinetic nuclear migration (GO:0022027)	3.32163565
24	cilium movement (GO:0003341)	3.29151533
25	translational termination (GO:0006415)	3.27935898
26	axonemal dynein complex assembly (GO:0070286)	3.26594352
27	maturation of SSU-rRNA (GO:0030490)	3.26134425
28	ribosomal small subunit assembly (GO:0000028)	3.20282108
29	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.19148312
30	chaperone-mediated protein complex assembly (GO:0051131)	3.17529874
31	DNA replication checkpoint (GO:0000076)	3.13688830
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.13489126
33	DNA deamination (GO:0045006)	3.11245836
34	purine nucleobase biosynthetic process (GO:0009113)	3.08534456
35	regulation of posttranscriptional gene silencing (GO:0060147)	3.08471303
36	regulation of gene silencing by miRNA (GO:0060964)	3.08471303
37	regulation of gene silencing by RNA (GO:0060966)	3.08471303
38	C4-dicarboxylate transport (GO:0015740)	3.07689952
39	translational elongation (GO:0006414)	3.05244857
40	behavioral response to ethanol (GO:0048149)	3.05083323
41	negative regulation of T cell differentiation in thymus (GO:0033085)	3.03282127
42	positive regulation of muscle cell apoptotic process (GO:0010661)	3.03252526
43	short-term memory (GO:0007614)	3.03003133
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.01905041
45	protein K6-linked ubiquitination (GO:0085020)	3.01540540
46	RNA localization (GO:0006403)	2.99445854
47	heparan sulfate proteoglycan metabolic process (GO:0030201)	2.98082523
48	intracellular protein transmembrane import (GO:0044743)	2.97874993
49	inner mitochondrial membrane organization (GO:0007007)	2.97454948
50	glomerular filtration (GO:0003094)	2.97176829
51	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.95741768
52	regulation of cardioblast proliferation (GO:0003264)	2.95308212
53	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.95308212
54	cotranslational protein targeting to membrane (GO:0006613)	2.94294340
55	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.94081048
56	pyrimidine nucleotide catabolic process (GO:0006244)	2.93638700
57	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.92849672
58	negative regulation of thymocyte apoptotic process (GO:0070244)	2.92035633
59	nephron epithelium morphogenesis (GO:0072088)	2.91650136
60	nephron tubule morphogenesis (GO:0072078)	2.91650136
61	intra-S DNA damage checkpoint (GO:0031573)	2.91263701
62	DNA damage response, detection of DNA damage (GO:0042769)	2.90708712
63	meiotic chromosome segregation (GO:0045132)	2.90003579
64	behavioral response to cocaine (GO:0048148)	2.87801994
65	resolution of meiotic recombination intermediates (GO:0000712)	2.87545739
66	cell proliferation in forebrain (GO:0021846)	2.87179201
67	protein polyglutamylation (GO:0018095)	2.86784140
68	protein targeting to ER (GO:0045047)	2.84917057
69	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.84389746
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.80549963
71	L-methionine salvage (GO:0071267)	2.80456867
72	L-methionine biosynthetic process (GO:0071265)	2.80456867
73	amino acid salvage (GO:0043102)	2.80456867
74	protein localization to endoplasmic reticulum (GO:0070972)	2.79126905
75	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.76493196
76	postreplication repair (GO:0006301)	2.75643203
77	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.74650484
78	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.74338870
79	epithelial cilium movement (GO:0003351)	2.74165986
80	myoblast migration (GO:0051451)	2.74160300
81	viral life cycle (GO:0019058)	2.72334976
82	regulation of spindle organization (GO:0090224)	2.70362225
83	establishment of protein localization to mitochondrion (GO:0072655)	2.67813194
84	nonmotile primary cilium assembly (GO:0035058)	2.64113774
85	translesion synthesis (GO:0019985)	2.63607479
86	ATP biosynthetic process (GO:0006754)	2.62714087
87	neuron fate determination (GO:0048664)	2.61958544
88	regulation of DNA endoreduplication (GO:0032875)	2.61023834
89	cellular protein complex disassembly (GO:0043624)	2.60693583
90	centriole replication (GO:0007099)	2.59729420
91	ribosomal large subunit biogenesis (GO:0042273)	2.59358610
92	negative regulation of appetite (GO:0032099)	2.58579304
93	negative regulation of response to food (GO:0032096)	2.58579304
94	hydrogen ion transmembrane transport (GO:1902600)	2.57113269
95	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.56421030
96	cardiac muscle cell proliferation (GO:0060038)	2.55863823
97	ribonucleoprotein complex biogenesis (GO:0022613)	2.53486248
98	DNA double-strand break processing (GO:0000729)	2.53203732
99	negative regulation of gene silencing (GO:0060969)	2.52618078
100	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.50508983

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.28988791
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.25243756
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84537105
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.79412391
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.40751546
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.12999888
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91533669
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.81586212
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.79359923
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.62840536
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.62434016
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.60760937
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.60707195
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.56783488
15	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.35248845
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.34674703
17	SOX2_18555785_ChIP-Seq_MESCs_Mouse	2.32654925
18	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.27244423
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.10544150
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08308808
21	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.99987818
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.98710819
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.98360426
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.97989461
25	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.95162611
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.92153955
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.87614415
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.85527948
29	EWS_26573619_Chip-Seq_HEK293_Human	1.82578742
30	XRN2_22483619_ChIP-Seq_HELA_Human	1.79823655
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.76935644
32	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.70475045
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.69722109
34	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.68992523
35	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.66289511
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63960640
37	VDR_22108803_ChIP-Seq_LS180_Human	1.62071269
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60429783
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59807850
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55864855
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.53061146
42	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.49470944
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.48737834
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47461507
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45857201
46	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.42705059
47	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.41468009
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41372380
49	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.40673045
50	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.34836899
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31982206
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.31087011
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29045279
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.28436066
55	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.27488252
56	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.27382191
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26620400
58	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.26221858
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22197410
60	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.20113780
61	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18561243
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.16433370
63	TP53_16413492_ChIP-PET_HCT116_Human	1.15522272
64	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.12984542
65	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10432097
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08774514
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08766805
68	ZNF274_21170338_ChIP-Seq_K562_Hela	1.08367746
69	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.08205229
70	FUS_26573619_Chip-Seq_HEK293_Human	1.05763463
71	TAF15_26573619_Chip-Seq_HEK293_Human	1.05366363
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04631009
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04631009
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04400714
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03493114
76	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.02938881
77	ERA_21632823_ChIP-Seq_H3396_Human	0.98919243
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98883883
79	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.98082463
80	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.98013834
81	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.97146768
82	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.95900068
83	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.95392405
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.92437863
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.91087464
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.90915767
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88885302
88	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.88281207
89	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.88273367
90	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.88256304
91	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.88135538
92	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.87850879
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86675494
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.86374082
95	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86341763
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85563140
97	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.84197570
98	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.83853342
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.83228115
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.81108321

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005174_abnormal_tail_pigmentation	3.61704629
2	MP0001188_hyperpigmentation	3.41985713
3	MP0006292_abnormal_olfactory_placode	3.19835102
4	MP0002234_abnormal_pharynx_morphology	3.17802562
5	MP0002938_white_spotting	2.69288723
6	MP0009379_abnormal_foot_pigmentation	2.63722385
7	MP0003136_yellow_coat_color	2.42361596
8	MP0005646_abnormal_pituitary_gland	2.23373099
9	MP0000569_abnormal_digit_pigmentation	10.5362911
10	MP0006072_abnormal_retinal_apoptosis	1.99989022
11	MP0002163_abnormal_gland_morphology	1.98066809
12	MP0003693_abnormal_embryo_hatching	1.88259014
13	MP0005623_abnormal_meninges_morphology	1.87797104
14	MP0001293_anophthalmia	1.84445598
15	MP0002277_abnormal_respiratory_mucosa	1.83493072
16	MP0002095_abnormal_skin_pigmentation	1.83335110
17	MP0008877_abnormal_DNA_methylation	1.75725058
18	MP0000371_diluted_coat_color	1.73249898
19	MP0000566_synostosis	1.72739748
20	MP0000631_abnormal_neuroendocrine_gland	1.72362784
21	MP0001529_abnormal_vocalization	1.68249494
22	MP0001905_abnormal_dopamine_level	1.65595883
23	MP0001984_abnormal_olfaction	1.63661376
24	MP0008007_abnormal_cellular_replicative	1.59662881
25	MP0002638_abnormal_pupillary_reflex	1.59030871
26	MP0003011_delayed_dark_adaptation	1.58593801
27	MP0002249_abnormal_larynx_morphology	1.56580886
28	MP0002102_abnormal_ear_morphology	1.56325086
29	MP0005084_abnormal_gallbladder_morpholo	1.55093586
30	MP0003567_abnormal_fetal_cardiomyocyte	1.51746094
31	MP0001286_abnormal_eye_development	1.49475108
32	MP0009053_abnormal_anal_canal	1.46865169
33	MP0000049_abnormal_middle_ear	1.46231368
34	MP0002697_abnormal_eye_size	1.34902480
35	MP0003937_abnormal_limbs/digits/tail_de	1.31859188
36	MP0001186_pigmentation_phenotype	1.31073254
37	MP0001346_abnormal_lacrimal_gland	1.27010884
38	MP0000467_abnormal_esophagus_morphology	1.26902631
39	MP0008058_abnormal_DNA_repair	1.24449031
40	MP0000678_abnormal_parathyroid_gland	1.22395433
41	MP0002075_abnormal_coat/hair_pigmentati	1.18396361
42	MP0003137_abnormal_impulse_conducting	1.17835104
43	MP0004133_heterotaxia	1.17498836
44	MP0001485_abnormal_pinna_reflex	1.09859192
45	MP0008875_abnormal_xenobiotic_pharmacok	1.08118173
46	MP0004142_abnormal_muscle_tone	1.04626198
47	MP0003787_abnormal_imprinting	1.02094520
48	MP0006035_abnormal_mitochondrial_morpho	1.01298267
49	MP0000026_abnormal_inner_ear	0.97485684
50	MP0002282_abnormal_trachea_morphology	0.96036552
51	MP0010307_abnormal_tumor_latency	0.95055261
52	MP0003315_abnormal_perineum_morphology	0.94343638
53	MP0002177_abnormal_outer_ear	0.93250866
54	MP0004957_abnormal_blastocyst_morpholog	0.92431377
55	MP0000778_abnormal_nervous_system	0.92116118
56	MP0005379_endocrine/exocrine_gland_phen	0.91495755
57	MP0002653_abnormal_ependyma_morphology	0.91159214
58	MP0002928_abnormal_bile_duct	0.91040658
59	MP0002210_abnormal_sex_determination	0.90737147
60	MP0004145_abnormal_muscle_electrophysio	0.90561747
61	MP0003786_premature_aging	0.90327214
62	MP0003880_abnormal_central_pattern	0.88426255
63	MP0003111_abnormal_nucleus_morphology	0.87341690
64	MP0003942_abnormal_urinary_system	0.87192812
65	MP0002736_abnormal_nociception_after	0.87172019
66	MP0010094_abnormal_chromosome_stability	0.86984245
67	MP0004147_increased_porphyrin_level	0.86521078
68	MP0002160_abnormal_reproductive_system	0.85509865
69	MP0002877_abnormal_melanocyte_morpholog	0.81405987
70	MP0005195_abnormal_posterior_eye	0.79825280
71	MP0003938_abnormal_ear_development	0.78573018
72	MP0004858_abnormal_nervous_system	0.78187217
73	MP0000639_abnormal_adrenal_gland	0.78164644
74	MP0001727_abnormal_embryo_implantation	0.76575366
75	MP0002751_abnormal_autonomic_nervous	0.76386438
76	MP0003755_abnormal_palate_morphology	0.75439635
77	MP0002932_abnormal_joint_morphology	0.73462783
78	MP0002233_abnormal_nose_morphology	0.71602949
79	MP0008872_abnormal_physiological_respon	0.71388903
80	MP0001929_abnormal_gametogenesis	0.71152375
81	MP0003122_maternal_imprinting	0.71002306
82	MP0008995_early_reproductive_senescence	0.68984269
83	MP0008932_abnormal_embryonic_tissue	0.68518837
84	MP0003698_abnormal_male_reproductive	0.68313361
85	MP0001764_abnormal_homeostasis	0.68250541
86	MP0008789_abnormal_olfactory_epithelium	0.67905348
87	MP0005408_hypopigmentation	0.67047691
88	MP0002111_abnormal_tail_morphology	0.66709885
89	MP0000427_abnormal_hair_cycle	0.66627679
90	MP0001145_abnormal_male_reproductive	0.66501073
91	MP0005645_abnormal_hypothalamus_physiol	0.65404156
92	MP0005391_vision/eye_phenotype	0.65189079
93	MP0009250_abnormal_appendicular_skeleto	0.62302105
94	MP0000579_abnormal_nail_morphology	0.61936904
95	MP0003121_genomic_imprinting	0.61414503
96	MP0002092_abnormal_eye_morphology	0.61012823
97	MP0000627_abnormal_mammary_gland	0.60642839
98	MP0003077_abnormal_cell_cycle	0.59519821
99	MP0002557_abnormal_social/conspecific_i	0.58588044
100	MP0008770_decreased_survivor_rate	0.56467264

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the pons (HP:0012110)	5.53820073
2	Abnormality of the pons (HP:0007361)	5.38262053
3	Congenital, generalized hypertrichosis (HP:0004540)	4.86598521
4	Molar tooth sign on MRI (HP:0002419)	3.84845877
5	Abnormality of midbrain morphology (HP:0002418)	3.84845877
6	Abnormal number of incisors (HP:0011064)	3.69868935
7	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.58654773
8	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.58654773
9	Abnormal ciliary motility (HP:0012262)	3.32724407
10	Aplastic anemia (HP:0001915)	3.28644551
11	Septo-optic dysplasia (HP:0100842)	3.26763358
12	Cortical visual impairment (HP:0100704)	3.20385946
13	Abnormal respiratory motile cilium physiology (HP:0012261)	3.13399843
14	Microretrognathia (HP:0000308)	3.06853612
15	Chronic hepatic failure (HP:0100626)	2.95126054
16	Panhypogammaglobulinemia (HP:0003139)	2.89216398
17	Dry hair (HP:0011359)	2.88309865
18	Squamous cell carcinoma (HP:0002860)	2.83339868
19	Increased hepatocellular lipid droplets (HP:0006565)	2.82369691
20	Pancreatic cysts (HP:0001737)	2.81139459
21	Sclerocornea (HP:0000647)	2.78066847
22	Recurrent cutaneous fungal infections (HP:0011370)	2.76293121
23	Chronic mucocutaneous candidiasis (HP:0002728)	2.76293121
24	Acute necrotizing encephalopathy (HP:0006965)	2.67521755
25	Macrocytic anemia (HP:0001972)	2.64794254
26	Woolly hair (HP:0002224)	2.63058078
27	Degeneration of anterior horn cells (HP:0002398)	2.62164030
28	Abnormality of the anterior horn cell (HP:0006802)	2.62164030
29	Mitochondrial inheritance (HP:0001427)	2.59090669
30	Abnormality of the 4th metacarpal (HP:0010012)	2.58443033
31	Nephronophthisis (HP:0000090)	2.56001454
32	Abnormality of cells of the erythroid lineage (HP:0012130)	2.55577834
33	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.54749720
34	Abnormality of secondary sexual hair (HP:0009888)	2.52442626
35	Abnormality of the axillary hair (HP:0100134)	2.52442626
36	Acute encephalopathy (HP:0006846)	2.49198830
37	Methylmalonic acidemia (HP:0002912)	2.48250931
38	Abnormal number of erythroid precursors (HP:0012131)	2.46542730
39	Epileptic encephalopathy (HP:0200134)	2.45710309
40	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42093978
41	Slow-growing hair (HP:0002217)	2.39517804
42	Abnormality of hair growth rate (HP:0011363)	2.39517804
43	Pancreatic fibrosis (HP:0100732)	2.39396798
44	Maternal diabetes (HP:0009800)	2.35396743
45	Esophageal atresia (HP:0002032)	2.34381504
46	Broad distal phalanx of finger (HP:0009836)	2.33384008
47	Pendular nystagmus (HP:0012043)	2.33365560
48	Lipid accumulation in hepatocytes (HP:0006561)	2.26370305
49	Methylmalonic aciduria (HP:0012120)	2.26099866
50	Abnormality of the middle phalanges of the toes (HP:0010183)	2.25751626
51	Concave nail (HP:0001598)	2.25360563
52	True hermaphroditism (HP:0010459)	2.23347511
53	Hepatic necrosis (HP:0002605)	2.20250874
54	Medial flaring of the eyebrow (HP:0010747)	2.19859397
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.18421734
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.18421734
57	Agammaglobulinemia (HP:0004432)	2.17726222
58	IgG deficiency (HP:0004315)	2.17089997
59	Patent foramen ovale (HP:0001655)	2.16475587
60	Progressive macrocephaly (HP:0004481)	2.15287395
61	Abolished electroretinogram (ERG) (HP:0000550)	2.12937343
62	Renal Fanconi syndrome (HP:0001994)	2.04994599
63	Aplasia/Hypoplasia of the patella (HP:0006498)	2.04617907
64	Hepatocellular necrosis (HP:0001404)	2.04381950
65	Increased intramyocellular lipid droplets (HP:0012240)	2.02515838
66	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.01604023
67	Increased CSF lactate (HP:0002490)	2.01384494
68	Hypotrichosis (HP:0001006)	1.99120242
69	Cerebral edema (HP:0002181)	1.98452533
70	Rib fusion (HP:0000902)	1.97530753
71	Patellar aplasia (HP:0006443)	1.96416220
72	Bifid tongue (HP:0010297)	1.95649829
73	Abnormality of the renal medulla (HP:0100957)	1.95085536
74	Intellectual disability, profound (HP:0002187)	1.92751064
75	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.92639252
76	Absent septum pellucidum (HP:0001331)	1.92506432
77	Bronchiectasis (HP:0002110)	1.92080954
78	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.91327183
79	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.89487126
80	Anophthalmia (HP:0000528)	1.88854588
81	Chronic bronchitis (HP:0004469)	1.87014316
82	Generalized aminoaciduria (HP:0002909)	1.83799118
83	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.83252870
84	Short middle phalanx of the 5th finger (HP:0004220)	1.82456184
85	Birth length less than 3rd percentile (HP:0003561)	1.80813542
86	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.78944991
87	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.76879577
88	Reticulocytopenia (HP:0001896)	1.76136610
89	Optic disc pallor (HP:0000543)	1.75831587
90	Cutaneous melanoma (HP:0012056)	1.73493875
91	Homocystinuria (HP:0002156)	1.72672471
92	Abnormality of homocysteine metabolism (HP:0010919)	1.72672471
93	Occipital encephalocele (HP:0002085)	1.72557432
94	Narrow forehead (HP:0000341)	1.71403866
95	Preaxial hand polydactyly (HP:0001177)	1.71309186
96	Hypoplasia of the radius (HP:0002984)	1.69290263
97	Anencephaly (HP:0002323)	1.69182937
98	Optic nerve hypoplasia (HP:0000609)	1.67997142
99	Nonprogressive disorder (HP:0003680)	1.67191378
100	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.67088124

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.66473858
2	MAPKAPK3	3.61450966
3	DYRK3	3.28915687
4	TSSK6	3.06436306
5	WEE1	3.03907733
6	ZAK	2.89687208
7	CDK19	2.32017408
8	CDC7	2.31127946
9	AKT3	2.25516151
10	NEK2	2.23656385
11	NEK1	2.19671648
12	TXK	2.02234733
13	VRK2	1.96819208
14	BMPR1B	1.95377296
15	MAP2K7	1.92162853
16	NUAK1	1.87654367
17	CSNK1G3	1.86284802
18	MAP4K2	1.85460809
19	MAP3K4	1.80505125
20	MKNK2	1.77523567
21	TTK	1.77420271
22	TYRO3	1.75732182
23	TLK1	1.70732533
24	ADRBK2	1.67194095
25	VRK1	1.66263942
26	CSNK1A1L	1.63362352
27	CSNK1G1	1.61962699
28	KDR	1.52562482
29	STK16	1.50089279
30	ERBB2	1.49227693
31	PLK3	1.43767101
32	MAPK15	1.42446574
33	MAP3K9	1.41222087
34	CSNK1G2	1.39187009
35	BUB1	1.33455306
36	FES	1.32902246
37	BCKDK	1.31089847
38	CDK8	1.26000512
39	MAP3K10	1.22684674
40	PLK4	1.19677164
41	TNK2	1.19559760
42	PLK2	1.18468137
43	BRSK2	1.13249035
44	ATR	1.01640000
45	FRK	0.97034923
46	OXSR1	0.95399122
47	TAOK3	0.86554869
48	PLK1	0.86511165
49	MKNK1	0.84486523
50	WNK4	0.78558810
51	AURKA	0.78478452
52	NTRK3	0.78288457
53	DYRK2	0.76628255
54	MAP2K4	0.76001617
55	JAK3	0.75237523
56	CHEK2	0.73104042
57	STK11	0.72895393
58	PIK3CA	0.61464919
59	EPHB2	0.59860740
60	CDK3	0.59769106
61	SRPK1	0.58928130
62	PRKCG	0.58482663
63	PBK	0.55113153
64	BRAF	0.54907912
65	MARK3	0.54154391
66	EPHA4	0.53802621
67	WNK3	0.50172868
68	RPS6KA5	0.49977539
69	AURKB	0.48094358
70	CAMK1D	0.46803249
71	TAF1	0.46624872
72	CSNK2A2	0.46304230
73	TAOK2	0.45942968
74	CSNK1A1	0.45768000
75	PTK6	0.45521520
76	RPS6KA4	0.45073784
77	RIPK4	0.44098992
78	CSNK2A1	0.42689457
79	STK24	0.42181666
80	MOS	0.42014836
81	NME1	0.40229128
82	DAPK1	0.39187619
83	CASK	0.35618740
84	CHUK	0.34889398
85	ATM	0.34111308
86	CDK4	0.32903995
87	PIM1	0.32798386
88	CAMK1G	0.31969243
89	CSNK1E	0.31016045
90	CCNB1	0.29021434
91	ADRBK1	0.28398022
92	GRK1	0.27290757
93	DMPK	0.27125973
94	MST4	0.23732510
95	IRAK2	0.23039010
96	STK39	0.22693030
97	INSRR	0.19468395
98	ITK	0.17700089
99	PRKACA	0.17434298
100	KIT	0.16631380

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.07756967
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.55712184
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.51264076
4	Homologous recombination_Homo sapiens_hsa03440	2.69425842
5	RNA polymerase_Homo sapiens_hsa03020	2.68637747
6	Proteasome_Homo sapiens_hsa03050	2.57646752
7	Parkinsons disease_Homo sapiens_hsa05012	2.56894804
8	Basal transcription factors_Homo sapiens_hsa03022	2.54465549
9	Mismatch repair_Homo sapiens_hsa03430	2.46382192
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.35571372
11	Sulfur relay system_Homo sapiens_hsa04122	2.27585463
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.19600760
13	Spliceosome_Homo sapiens_hsa03040	2.17784008
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.14114367
15	Primary immunodeficiency_Homo sapiens_hsa05340	2.07609000
16	Asthma_Homo sapiens_hsa05310	2.01807470
17	Huntingtons disease_Homo sapiens_hsa05016	1.95838168
18	Allograft rejection_Homo sapiens_hsa05330	1.92219494
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90933105
20	Protein export_Homo sapiens_hsa03060	1.88131852
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.84453743
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84318377
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.73146461
24	Alzheimers disease_Homo sapiens_hsa05010	1.69030664
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.64306842
26	Base excision repair_Homo sapiens_hsa03410	1.56839275
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.47254140
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.46988082
29	RNA degradation_Homo sapiens_hsa03018	1.42311587
30	Folate biosynthesis_Homo sapiens_hsa00790	1.39340838
31	Caffeine metabolism_Homo sapiens_hsa00232	1.38862995
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32417505
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.31915691
34	DNA replication_Homo sapiens_hsa03030	1.24081835
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22147473
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18003794
37	p53 signaling pathway_Homo sapiens_hsa04115	1.17439886
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.14074624
39	Notch signaling pathway_Homo sapiens_hsa04330	1.09976018
40	RNA transport_Homo sapiens_hsa03013	1.07665119
41	One carbon pool by folate_Homo sapiens_hsa00670	1.04277458
42	Phototransduction_Homo sapiens_hsa04744	1.04244126
43	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.04012704
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01291968
45	Tryptophan metabolism_Homo sapiens_hsa00380	1.00462262
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98335711
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.97429609
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.96854896
49	Viral myocarditis_Homo sapiens_hsa05416	0.96108619
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.95762756
51	Purine metabolism_Homo sapiens_hsa00230	0.93872261
52	Sulfur metabolism_Homo sapiens_hsa00920	0.92446454
53	Regulation of autophagy_Homo sapiens_hsa04140	0.86321116
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.84560964
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.80776130
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.78942829
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.75190790
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74855910
59	Fatty acid elongation_Homo sapiens_hsa00062	0.64980448
60	Butanoate metabolism_Homo sapiens_hsa00650	0.64479408
61	Olfactory transduction_Homo sapiens_hsa04740	0.63658788
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.61697675
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60960345
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59967876
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.58005513
66	Cell cycle_Homo sapiens_hsa04110	0.56237465
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55173553
68	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.55051824
69	Propanoate metabolism_Homo sapiens_hsa00640	0.47870648
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.46969826
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45947880
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45870089
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44625382
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.44540196
75	Metabolic pathways_Homo sapiens_hsa01100	0.43522147
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42409187
77	Wnt signaling pathway_Homo sapiens_hsa04310	0.41017962
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.37757325
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37638209
80	Prion diseases_Homo sapiens_hsa05020	0.36529827
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36077497
82	Peroxisome_Homo sapiens_hsa04146	0.36009332
83	Fatty acid degradation_Homo sapiens_hsa00071	0.35422886
84	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35146456
85	Oocyte meiosis_Homo sapiens_hsa04114	0.34675831
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33486414
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32964599
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.31864384
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30658032
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.29805568
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.28905943
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.27832672
93	Retinol metabolism_Homo sapiens_hsa00830	0.26966838
94	Shigellosis_Homo sapiens_hsa05131	0.26516814
95	Herpes simplex infection_Homo sapiens_hsa05168	0.25873265
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25669369
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.24104376
98	Leishmaniasis_Homo sapiens_hsa05140	0.23411355
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23301437
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22406034

HMGN1P37

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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