HMGN1P38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.03623476
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.98929587
3DNA deamination (GO:0045006)6.95282110
4cytidine metabolic process (GO:0046087)6.08126073
5cytidine catabolic process (GO:0006216)6.08126073
6cytidine deamination (GO:0009972)6.08126073
7maturation of SSU-rRNA (GO:0030490)5.69444108
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.57773186
9chaperone-mediated protein transport (GO:0072321)5.39104721
10sequestering of actin monomers (GO:0042989)5.29110414
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.21219953
12pyrimidine ribonucleoside catabolic process (GO:0046133)5.10423773
13viral transcription (GO:0019083)5.08388029
14translational termination (GO:0006415)4.98839094
15ribosomal small subunit biogenesis (GO:0042274)4.80623286
16ATP synthesis coupled proton transport (GO:0015986)4.55683067
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55683067
18translational elongation (GO:0006414)4.53206383
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.40882792
20cotranslational protein targeting to membrane (GO:0006613)4.38015251
21protein targeting to ER (GO:0045047)4.34087364
22respiratory electron transport chain (GO:0022904)4.27350455
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.24995185
24electron transport chain (GO:0022900)4.22979690
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15207394
26response to pheromone (GO:0019236)4.11868308
27regulation of mitochondrial translation (GO:0070129)4.05966699
28protein localization to endoplasmic reticulum (GO:0070972)4.01506568
29cellular protein complex disassembly (GO:0043624)3.98977889
30protein neddylation (GO:0045116)3.93869995
31dopamine transport (GO:0015872)3.90350256
32substrate-independent telencephalic tangential migration (GO:0021826)3.87435503
33substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.87435503
34viral life cycle (GO:0019058)3.84981329
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56334209
36negative regulation by host of viral transcription (GO:0043922)3.54373394
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49077878
38protein complex biogenesis (GO:0070271)3.44983061
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44799591
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.41634479
41protein complex disassembly (GO:0043241)3.36919665
42ribosomal large subunit biogenesis (GO:0042273)3.34810031
43cell proliferation in forebrain (GO:0021846)3.34688188
44proteasome assembly (GO:0043248)3.30883333
45regulation of activation of Janus kinase activity (GO:0010533)3.26729393
46deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21103826
47translational initiation (GO:0006413)3.20709440
48macromolecular complex disassembly (GO:0032984)3.19320429
49translation (GO:0006412)3.12312998
50mitochondrial respiratory chain complex assembly (GO:0033108)3.11570336
51platelet dense granule organization (GO:0060155)3.09340002
52protein-cofactor linkage (GO:0018065)3.08749914
53inner mitochondrial membrane organization (GO:0007007)3.07234183
54termination of RNA polymerase III transcription (GO:0006386)3.06052823
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.06052823
56water-soluble vitamin biosynthetic process (GO:0042364)3.01346740
57regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93816371
58regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93816371
59maturation of 5.8S rRNA (GO:0000460)2.89550072
60protein targeting to membrane (GO:0006612)2.82681980
61positive regulation of respiratory burst (GO:0060267)2.82503091
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78919750
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.78919750
64NADH dehydrogenase complex assembly (GO:0010257)2.78919750
65nuclear-transcribed mRNA catabolic process (GO:0000956)2.78349315
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.76853417
67transmission of nerve impulse (GO:0019226)2.73737561
68chromatin remodeling at centromere (GO:0031055)2.70970162
69protein polyglutamylation (GO:0018095)2.69598317
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69457503
71CENP-A containing nucleosome assembly (GO:0034080)2.69398078
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65851843
73mRNA catabolic process (GO:0006402)2.65054705
74cellular component biogenesis (GO:0044085)2.63595870
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63219000
76pyrimidine nucleotide catabolic process (GO:0006244)2.62686546
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62516692
78pyrimidine-containing compound catabolic process (GO:0072529)2.62172540
79ribonucleoprotein complex biogenesis (GO:0022613)2.61849008
80microtubule depolymerization (GO:0007019)2.61727658
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60254447
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60254447
83hydrogen ion transmembrane transport (GO:1902600)2.58889258
84spliceosomal complex assembly (GO:0000245)2.57734820
85negative regulation of telomere maintenance (GO:0032205)2.57179350
86monocyte chemotaxis (GO:0002548)2.55982417
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54845923
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54845923
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54845923
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54051126
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54051126
92modulation by host of viral transcription (GO:0043921)2.50968158
93modulation by host of symbiont transcription (GO:0052472)2.50968158
94DNA replication-dependent nucleosome organization (GO:0034723)2.49392263
95DNA replication-dependent nucleosome assembly (GO:0006335)2.49392263
96negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.48932384
97rRNA processing (GO:0006364)2.48469355
98pyrimidine nucleoside catabolic process (GO:0046135)2.48228168
99DNA replication checkpoint (GO:0000076)2.47274033
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45066379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.84443863
2EZH2_22144423_ChIP-Seq_EOC_Human3.69764078
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67137358
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.65242201
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.58484056
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44694069
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09501054
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01724399
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01022918
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80298860
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76765657
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75030351
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71102029
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67298332
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48693891
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.34810541
17VDR_23849224_ChIP-Seq_CD4+_Human2.34787695
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.34679800
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32405816
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08659282
21ELK1_19687146_ChIP-ChIP_HELA_Human1.94544649
22FOXP3_21729870_ChIP-Seq_TREG_Human1.91542093
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87771427
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84238484
25VDR_22108803_ChIP-Seq_LS180_Human1.82258560
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80976945
27MYC_18940864_ChIP-ChIP_HL60_Human1.80951807
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.75827519
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72768031
30ZNF274_21170338_ChIP-Seq_K562_Hela1.72737053
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71949926
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70755975
33EWS_26573619_Chip-Seq_HEK293_Human1.69358793
34TTF2_22483619_ChIP-Seq_HELA_Human1.57750134
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56093032
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55801726
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.53399302
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52968840
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47922054
40XRN2_22483619_ChIP-Seq_HELA_Human1.47765779
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.46011789
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.45017896
43DCP1A_22483619_ChIP-Seq_HELA_Human1.42754563
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.42180064
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39704348
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39011936
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37834719
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36364463
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32004377
50FUS_26573619_Chip-Seq_HEK293_Human1.27365235
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22966436
52GABP_19822575_ChIP-Seq_HepG2_Human1.22735715
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21518274
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21390777
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20220189
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19535633
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17635853
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.16375956
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13734588
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12062740
61AR_20517297_ChIP-Seq_VCAP_Human1.11750343
62E2F7_22180533_ChIP-Seq_HELA_Human1.10997704
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09108618
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09041711
65HTT_18923047_ChIP-ChIP_STHdh_Human1.05591422
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05434280
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05111998
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04960657
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04127131
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.03521831
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.03465135
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.02443994
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02443994
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01650350
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01197027
76TP53_22573176_ChIP-Seq_HFKS_Human1.00946033
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99986990
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98517017
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98189645
80CBP_20019798_ChIP-Seq_JUKART_Human0.98189645
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97039210
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96731805
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94182077
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93327718
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.92505714
86RNF2_27304074_Chip-Seq_NSC_Mouse0.91289095
87CIITA_25753668_ChIP-Seq_RAJI_Human0.91249878
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90309858
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90251672
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90059343
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89210894
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87856962
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85963427
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85607790
95TAF15_26573619_Chip-Seq_HEK293_Human0.84423693
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83514873
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83361927
98TAF2_19829295_ChIP-Seq_ESCs_Human0.83194887
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82453433
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81136350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.24410006
2MP0003880_abnormal_central_pattern5.40426137
3MP0002653_abnormal_ependyma_morphology4.33917080
4MP0003136_yellow_coat_color3.69375842
5MP0006292_abnormal_olfactory_placode3.31872803
6MP0005671_abnormal_response_to2.93338765
7MP0002102_abnormal_ear_morphology2.83244290
8MP0002234_abnormal_pharynx_morphology2.50807658
9MP0001293_anophthalmia2.26661695
10MP0003011_delayed_dark_adaptation2.16901408
11MP0006072_abnormal_retinal_apoptosis1.91443224
12MP0005084_abnormal_gallbladder_morpholo1.89397966
13MP0005645_abnormal_hypothalamus_physiol1.81679939
14MP0001529_abnormal_vocalization1.74662220
15MP0003693_abnormal_embryo_hatching1.69760150
16MP0003938_abnormal_ear_development1.69480151
17MP0004145_abnormal_muscle_electrophysio1.67252959
18MP0004147_increased_porphyrin_level1.65321237
19MP0002277_abnormal_respiratory_mucosa1.63310207
20MP0005174_abnormal_tail_pigmentation1.58019012
21MP0004142_abnormal_muscle_tone1.54401077
22MP0005253_abnormal_eye_physiology1.47756877
23MP0002095_abnormal_skin_pigmentation1.45621494
24MP0000026_abnormal_inner_ear1.44733023
25MP0009046_muscle_twitch1.40856910
26MP0003786_premature_aging1.39676506
27MP0003646_muscle_fatigue1.39108451
28MP0002638_abnormal_pupillary_reflex1.37788831
29MP0002876_abnormal_thyroid_physiology1.32908682
30MP0001905_abnormal_dopamine_level1.31955909
31MP0008058_abnormal_DNA_repair1.31456231
32MP0008877_abnormal_DNA_methylation1.24878034
33MP0001485_abnormal_pinna_reflex1.21904777
34MP0009785_altered_susceptibility_to1.18557528
35MP0003763_abnormal_thymus_physiology1.18048554
36MP0000631_abnormal_neuroendocrine_gland1.17496413
37MP0004742_abnormal_vestibular_system1.16597223
38MP0000049_abnormal_middle_ear1.15020234
39MP0005075_abnormal_melanosome_morpholog1.09742132
40MP0001764_abnormal_homeostasis1.09307731
41MP0008872_abnormal_physiological_respon1.09175932
42MP0005391_vision/eye_phenotype1.08699170
43MP0003878_abnormal_ear_physiology1.07482309
44MP0005377_hearing/vestibular/ear_phenot1.07482309
45MP0010094_abnormal_chromosome_stability1.05774687
46MP0000372_irregular_coat_pigmentation1.03752690
47MP0000778_abnormal_nervous_system1.03603084
48MP0008007_abnormal_cellular_replicative1.01545439
49MP0002736_abnormal_nociception_after0.99581594
50MP0001188_hyperpigmentation0.98534935
51MP0001873_stomach_inflammation0.94481541
52MP0002938_white_spotting0.93279017
53MP0003866_abnormal_defecation0.93166502
54MP0005551_abnormal_eye_electrophysiolog0.93065227
55MP0002160_abnormal_reproductive_system0.92746554
56MP0008789_abnormal_olfactory_epithelium0.92575407
57MP0002822_catalepsy0.89543039
58MP0003806_abnormal_nucleotide_metabolis0.88832925
59MP0003787_abnormal_imprinting0.87177329
60MP0002210_abnormal_sex_determination0.84534854
61MP0004957_abnormal_blastocyst_morpholog0.82484858
62MP0005389_reproductive_system_phenotype0.81061870
63MP0006276_abnormal_autonomic_nervous0.81052572
64MP0003111_abnormal_nucleus_morphology0.80920254
65MP0001800_abnormal_humoral_immune0.80725605
66MP0008995_early_reproductive_senescence0.80091409
67MP0001286_abnormal_eye_development0.79692156
68MP0002928_abnormal_bile_duct0.79296964
69MP0005195_abnormal_posterior_eye0.76942732
70MP0000685_abnormal_immune_system0.76836202
71MP0003937_abnormal_limbs/digits/tail_de0.76324564
72MP0001324_abnormal_eye_pigmentation0.75366122
73MP0001919_abnormal_reproductive_system0.72681323
74MP0000703_abnormal_thymus_morphology0.72459150
75MP0001984_abnormal_olfaction0.69438475
76MP0002751_abnormal_autonomic_nervous0.68063822
77MP0005387_immune_system_phenotype0.66957111
78MP0001790_abnormal_immune_system0.66957111
79MP0002697_abnormal_eye_size0.66953514
80MP0002272_abnormal_nervous_system0.66630985
81MP0001963_abnormal_hearing_physiology0.66480794
82MP0001879_abnormal_lymphatic_vessel0.66440641
83MP0009745_abnormal_behavioral_response0.64398527
84MP0002420_abnormal_adaptive_immunity0.63822772
85MP0002249_abnormal_larynx_morphology0.63735650
86MP0002752_abnormal_somatic_nervous0.63480353
87MP0003119_abnormal_digestive_system0.63069725
88MP0002398_abnormal_bone_marrow0.62278792
89MP0002233_abnormal_nose_morphology0.62082175
90MP0001929_abnormal_gametogenesis0.61786922
91MP0004885_abnormal_endolymph0.61720887
92MP0001968_abnormal_touch/_nociception0.60915081
93MP0001819_abnormal_immune_cell0.60473078
94MP0002837_dystrophic_cardiac_calcinosis0.60385866
95MP0008932_abnormal_embryonic_tissue0.60164801
96MP0006036_abnormal_mitochondrial_physio0.59934545
97MP0005646_abnormal_pituitary_gland0.58989083
98MP0002166_altered_tumor_susceptibility0.57438721
99MP0001119_abnormal_female_reproductive0.57425340
100MP0002723_abnormal_immune_serum0.57116142

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.70857971
2Acute necrotizing encephalopathy (HP:0006965)4.53809594
3Reticulocytopenia (HP:0001896)4.37127635
4Abnormal mitochondria in muscle tissue (HP:0008316)4.11413785
5Mitochondrial inheritance (HP:0001427)4.10708701
6Increased hepatocellular lipid droplets (HP:0006565)4.07984568
7Lipid accumulation in hepatocytes (HP:0006561)3.85097525
811 pairs of ribs (HP:0000878)3.74860771
9Acute encephalopathy (HP:0006846)3.67154153
10Progressive macrocephaly (HP:0004481)3.59445040
11Fibular aplasia (HP:0002990)3.57575056
12Abnormal number of erythroid precursors (HP:0012131)3.46907992
13Increased CSF lactate (HP:0002490)3.44204054
14Renal Fanconi syndrome (HP:0001994)3.43910539
15Abnormality of cells of the erythroid lineage (HP:0012130)3.32360310
16Increased intramyocellular lipid droplets (HP:0012240)3.23005406
17Hepatocellular necrosis (HP:0001404)3.07320057
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06237702
19Adactyly (HP:0009776)2.97167149
20Radial bowing (HP:0002986)2.96463646
21Hypoplastic pelvis (HP:0008839)2.95176478
22Macrocytic anemia (HP:0001972)2.92541132
23Congenital stationary night blindness (HP:0007642)2.91790186
24Cerebral edema (HP:0002181)2.90476518
25Synostosis involving the elbow (HP:0003938)2.85510449
26Humeroradial synostosis (HP:0003041)2.85510449
27Hepatic necrosis (HP:0002605)2.82719483
28Increased muscle lipid content (HP:0009058)2.80400848
29Absent thumb (HP:0009777)2.71179761
30Abnormality of the parietal bone (HP:0002696)2.71095466
313-Methylglutaconic aciduria (HP:0003535)2.69634252
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65197485
33IgG deficiency (HP:0004315)2.60669811
34Aplasia/hypoplasia of the uterus (HP:0008684)2.60064254
35Respiratory difficulties (HP:0002880)2.57477294
36Exertional dyspnea (HP:0002875)2.51638793
37T lymphocytopenia (HP:0005403)2.50793361
38Hypoplasia of the radius (HP:0002984)2.42924068
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42216982
40Pallor (HP:0000980)2.37684340
41Abnormal number of incisors (HP:0011064)2.33183944
42Molar tooth sign on MRI (HP:0002419)2.31391899
43Abnormality of midbrain morphology (HP:0002418)2.31391899
44Abnormality of T cell number (HP:0011839)2.31230142
45Pancreatic cysts (HP:0001737)2.28578068
46Aplasia/Hypoplasia of the fibula (HP:0006492)2.26955566
47Symphalangism affecting the phalanges of the hand (HP:0009773)2.26776360
48Colon cancer (HP:0003003)2.23931006
49Pancytopenia (HP:0001876)2.23354829
50Methylmalonic acidemia (HP:0002912)2.19411321
51Abnormality of renal resorption (HP:0011038)2.17952783
52Oligodactyly (hands) (HP:0001180)2.17054737
53Aplasia/Hypoplasia of the patella (HP:0006498)2.15958940
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.14696497
55Leukodystrophy (HP:0002415)2.14634961
56Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.14240913
57Oral leukoplakia (HP:0002745)2.13911204
58Short tibia (HP:0005736)2.13178531
59Missing ribs (HP:0000921)2.12476063
60Partial duplication of thumb phalanx (HP:0009944)2.12386501
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11436306
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11436306
63Exercise intolerance (HP:0003546)2.10387866
64Methylmalonic aciduria (HP:0012120)2.09785433
65Sclerocornea (HP:0000647)2.07347067
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05284455
67Optic disc pallor (HP:0000543)2.04730367
68Forearm undergrowth (HP:0009821)1.99773396
69Lactic acidosis (HP:0003128)1.98373044
70Aplasia/Hypoplasia of the ulna (HP:0006495)1.96551214
71Partial duplication of the phalanx of hand (HP:0009999)1.96452862
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.94916726
73Abnormality of the pons (HP:0007361)1.93297957
74Hypoplasia of the pons (HP:0012110)1.91900944
75Increased serum lactate (HP:0002151)1.91630238
76Abnormality of urine glucose concentration (HP:0011016)1.91591946
77Glycosuria (HP:0003076)1.91591946
78Patellar aplasia (HP:0006443)1.90465446
79Abnormality of T cells (HP:0002843)1.88928642
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88872541
81Duplication of thumb phalanx (HP:0009942)1.88228747
82Oligodactyly (HP:0012165)1.87753974
83Severe combined immunodeficiency (HP:0004430)1.85192794
84Bilateral microphthalmos (HP:0007633)1.83925127
85Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82972902
86Dicarboxylic aciduria (HP:0003215)1.82972902
87Congenital, generalized hypertrichosis (HP:0004540)1.82238758
88Triphalangeal thumb (HP:0001199)1.82120151
89Hyperglycinemia (HP:0002154)1.81530095
90Short thumb (HP:0009778)1.81419165
91Respiratory failure (HP:0002878)1.80614168
92Chromsome breakage (HP:0040012)1.79080738
93Abnormality of the renal collecting system (HP:0004742)1.77594344
94Pancreatic fibrosis (HP:0100732)1.75321095
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75171867
96Short 4th metacarpal (HP:0010044)1.75171867
97Hemivertebrae (HP:0002937)1.74346938
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73522985
99Lethargy (HP:0001254)1.73039757
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70934689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.24039862
2TESK24.48849278
3VRK24.04478653
4TXK3.94420384
5VRK13.16738447
6BUB13.07232024
7KDR3.05520039
8ZAK2.77070769
9BCKDK2.60430835
10STK161.98417530
11TAF11.89622459
12MAP4K21.84797934
13DYRK21.75715458
14CDC71.73154635
15NUAK11.70748971
16GRK11.63188859
17CDK191.60081225
18BRSK21.52987648
19ADRBK21.46681285
20TNIK1.36764812
21WEE11.31713393
22SRPK11.23734221
23MAP4K11.23624993
24NME11.21423142
25LIMK11.17727678
26WNK41.17629334
27GRK71.16554495
28SYK1.11168909
29AURKA1.07520440
30WNK31.05302134
31ACVR1B1.04431092
32INSRR1.02965265
33ITK0.99722360
34TAOK30.99577201
35TESK10.99303836
36MAP3K120.96177912
37RPS6KA50.92519333
38MAP2K70.89928815
39CHEK20.87610061
40OXSR10.86132013
41MAPK150.83033400
42MAP3K40.82158542
43BMPR1B0.81869615
44PIK3CA0.79852961
45MAPK130.79669081
46MAPKAPK50.76981987
47PRKCQ0.74028704
48NTRK20.73146633
49NEK20.72688506
50EPHB20.72494543
51ADRBK10.70623554
52PLK10.70195551
53AURKB0.69125332
54PLK30.68198268
55DAPK30.65764990
56MUSK0.65488161
57PRKCG0.65137752
58CLK10.64310529
59CCNB10.61510095
60TIE10.61181884
61TYRO30.61076602
62UHMK10.60618773
63PLK40.56786218
64MKNK20.54437823
65LCK0.53428162
66CDK80.52607092
67ATR0.52185947
68NEK10.51282795
69PINK10.51208632
70PASK0.49567431
71CSNK2A10.47951767
72KIT0.46281311
73FES0.46261560
74MAP3K130.43434233
75PIM10.43082868
76MKNK10.43039091
77LYN0.41100453
78CAMKK20.40946001
79PHKG20.40488648
80PHKG10.40488648
81STK390.39671636
82CSF1R0.39265112
83CSNK2A20.39209369
84CDK11A0.38797550
85PKN10.38580507
86MST40.38054203
87DAPK10.37381478
88BRSK10.36966411
89MAP3K110.35596591
90PNCK0.35470737
91DYRK1A0.35316431
92IKBKE0.34899864
93EIF2AK20.33128444
94CDK150.32972443
95GRK50.32305381
96STK38L0.31267324
97PRKACA0.30728904
98DAPK20.30128662
99CDK180.29510559
100MARK10.29292923

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.73404446
2Oxidative phosphorylation_Homo sapiens_hsa001904.19877905
3Parkinsons disease_Homo sapiens_hsa050123.87659372
4Proteasome_Homo sapiens_hsa030503.55879256
5Primary immunodeficiency_Homo sapiens_hsa053403.36556909
6RNA polymerase_Homo sapiens_hsa030202.72399560
7Huntingtons disease_Homo sapiens_hsa050162.54834118
8Alzheimers disease_Homo sapiens_hsa050102.53568650
9Protein export_Homo sapiens_hsa030602.48164101
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35186381
11Systemic lupus erythematosus_Homo sapiens_hsa053222.21564345
12Cardiac muscle contraction_Homo sapiens_hsa042602.20827516
13Homologous recombination_Homo sapiens_hsa034402.10174811
14Mismatch repair_Homo sapiens_hsa034301.87988518
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85623516
16DNA replication_Homo sapiens_hsa030301.82202455
17Fanconi anemia pathway_Homo sapiens_hsa034601.72394787
18Spliceosome_Homo sapiens_hsa030401.70581946
19Autoimmune thyroid disease_Homo sapiens_hsa053201.68263814
20Antigen processing and presentation_Homo sapiens_hsa046121.64092462
21Phototransduction_Homo sapiens_hsa047441.57055663
22Nucleotide excision repair_Homo sapiens_hsa034201.52427877
23Allograft rejection_Homo sapiens_hsa053301.50960665
24Basal transcription factors_Homo sapiens_hsa030221.49044342
25Graft-versus-host disease_Homo sapiens_hsa053321.47684190
26RNA degradation_Homo sapiens_hsa030181.41105072
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31121788
28One carbon pool by folate_Homo sapiens_hsa006701.29455442
29Alcoholism_Homo sapiens_hsa050341.28844508
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26844227
31Pyrimidine metabolism_Homo sapiens_hsa002401.25862682
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19544148
33Folate biosynthesis_Homo sapiens_hsa007901.18537474
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.17469791
35Hedgehog signaling pathway_Homo sapiens_hsa043401.13642432
36Type I diabetes mellitus_Homo sapiens_hsa049401.07883873
37Sulfur relay system_Homo sapiens_hsa041221.06291567
38Base excision repair_Homo sapiens_hsa034101.05191113
39Hematopoietic cell lineage_Homo sapiens_hsa046400.96571108
40Nitrogen metabolism_Homo sapiens_hsa009100.92061027
41Rheumatoid arthritis_Homo sapiens_hsa053230.89146590
42Collecting duct acid secretion_Homo sapiens_hsa049660.85509577
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84393773
44Butanoate metabolism_Homo sapiens_hsa006500.84340354
45Basal cell carcinoma_Homo sapiens_hsa052170.82437038
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81819865
47Asthma_Homo sapiens_hsa053100.81317480
48Purine metabolism_Homo sapiens_hsa002300.81029840
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75378267
50Linoleic acid metabolism_Homo sapiens_hsa005910.75018098
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71581108
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.70752577
53Propanoate metabolism_Homo sapiens_hsa006400.69916744
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67783479
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66977529
56RNA transport_Homo sapiens_hsa030130.66559903
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65535754
58Nicotine addiction_Homo sapiens_hsa050330.65285333
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64032666
60Vitamin digestion and absorption_Homo sapiens_hsa049770.60784911
61Peroxisome_Homo sapiens_hsa041460.56960952
62p53 signaling pathway_Homo sapiens_hsa041150.55843029
63T cell receptor signaling pathway_Homo sapiens_hsa046600.55649439
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53552012
65Metabolic pathways_Homo sapiens_hsa011000.52349072
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48883635
67Steroid biosynthesis_Homo sapiens_hsa001000.47156946
68Renin-angiotensin system_Homo sapiens_hsa046140.46203392
69Olfactory transduction_Homo sapiens_hsa047400.42212299
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.41822099
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40587563
72Tyrosine metabolism_Homo sapiens_hsa003500.38053125
73Epstein-Barr virus infection_Homo sapiens_hsa051690.36562207
74mRNA surveillance pathway_Homo sapiens_hsa030150.36021845
75Regulation of autophagy_Homo sapiens_hsa041400.34901925
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34782247
77Tryptophan metabolism_Homo sapiens_hsa003800.34160760
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.33337577
79Pyruvate metabolism_Homo sapiens_hsa006200.32853286
80Retinol metabolism_Homo sapiens_hsa008300.32852351
81Fatty acid elongation_Homo sapiens_hsa000620.31556678
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30943176
83Prion diseases_Homo sapiens_hsa050200.30619894
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.29504246
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25941881
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25675620
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.24722710
88Shigellosis_Homo sapiens_hsa051310.24647556
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24281030
90Sulfur metabolism_Homo sapiens_hsa009200.24207245
91Morphine addiction_Homo sapiens_hsa050320.23169827
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22773332
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22025745
94Viral myocarditis_Homo sapiens_hsa054160.21680285
95Caffeine metabolism_Homo sapiens_hsa002320.21601440
96Fatty acid degradation_Homo sapiens_hsa000710.21165403
97Cell cycle_Homo sapiens_hsa041100.20640952
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.18564595
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16409322
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15731138

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