HMGN1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)5.79174921
2regulation of DNA endoreduplication (GO:0032875)5.24577654
3pyrimidine nucleobase catabolic process (GO:0006208)4.46503800
4response to pheromone (GO:0019236)4.30050952
5negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.15091582
6protein K11-linked deubiquitination (GO:0035871)4.03683577
7behavioral response to nicotine (GO:0035095)3.98108621
8neural tube formation (GO:0001841)3.97647837
9indolalkylamine metabolic process (GO:0006586)3.89899922
10negative regulation of DNA-dependent DNA replication (GO:2000104)3.76969565
11negative regulation of dendrite morphogenesis (GO:0050774)3.75736336
12DNA damage induced protein phosphorylation (GO:0006975)3.69503245
13meiotic chromosome segregation (GO:0045132)3.69286910
14tryptophan metabolic process (GO:0006568)3.68283509
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.61072926
16somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61072926
17single strand break repair (GO:0000012)3.58735737
18negative regulation of circadian rhythm (GO:0042754)3.58171746
19histone mRNA catabolic process (GO:0071044)3.55081115
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51425646
21ubiquinone metabolic process (GO:0006743)3.42905796
22neuron maturation (GO:0042551)3.40369619
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.40145195
24negative regulation of translation, ncRNA-mediated (GO:0040033)3.40145195
25regulation of translation, ncRNA-mediated (GO:0045974)3.40145195
26auditory behavior (GO:0031223)3.39271294
27regulation of acrosome reaction (GO:0060046)3.37754039
28nucleobase catabolic process (GO:0046113)3.35754383
29olfactory bulb development (GO:0021772)3.20126975
30microtubule nucleation (GO:0007020)3.17704175
31positive regulation of growth hormone secretion (GO:0060124)3.15869011
32regulation of stem cell maintenance (GO:2000036)3.13795762
33kynurenine metabolic process (GO:0070189)3.10694662
34negative regulation of dendrite development (GO:2000171)3.08955261
35synapsis (GO:0007129)3.08563705
36indolalkylamine catabolic process (GO:0046218)3.08407589
37tryptophan catabolic process (GO:0006569)3.08407589
38indole-containing compound catabolic process (GO:0042436)3.08407589
39negative regulation of DNA recombination (GO:0045910)3.07400713
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.05846088
41negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.04613305
42cellular biogenic amine catabolic process (GO:0042402)3.03530014
43amine catabolic process (GO:0009310)3.03530014
44regulation of chromatin binding (GO:0035561)3.02397285
45lysine metabolic process (GO:0006553)3.02192376
46lysine catabolic process (GO:0006554)3.02192376
47activated T cell proliferation (GO:0050798)3.00614079
48cornea development in camera-type eye (GO:0061303)2.97351254
49ubiquinone biosynthetic process (GO:0006744)2.96008554
50cerebellar Purkinje cell differentiation (GO:0021702)2.95433490
51epithelial cilium movement (GO:0003351)2.94475752
52protein import into peroxisome matrix (GO:0016558)2.88799092
53sulfate transmembrane transport (GO:1902358)2.85319799
54negative regulation of histone methylation (GO:0031061)2.81411070
55replication fork processing (GO:0031297)2.80728948
56regulation of fever generation (GO:0031620)2.80158086
57somatic diversification of immunoglobulins (GO:0016445)2.79542983
58ncRNA 3-end processing (GO:0043628)2.74875216
59regulation of growth hormone secretion (GO:0060123)2.74325055
60replicative senescence (GO:0090399)2.74193815
61histamine secretion (GO:0001821)2.73723130
62histone H3-K4 methylation (GO:0051568)2.73503945
63DNA-dependent DNA replication (GO:0006261)2.73053557
64regulation of meiosis I (GO:0060631)2.72124398
65regulation of heat generation (GO:0031650)2.71660820
66forebrain neuron differentiation (GO:0021879)2.71589587
67positive regulation of heat generation (GO:0031652)2.69836415
68regulation of helicase activity (GO:0051095)2.69593715
69regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.68939700
70protein localization to cilium (GO:0061512)2.68476343
71photoreceptor cell differentiation (GO:0046530)2.68131433
72eye photoreceptor cell differentiation (GO:0001754)2.68131433
73neurofilament cytoskeleton organization (GO:0060052)2.66901941
74startle response (GO:0001964)2.66493929
75protoporphyrinogen IX biosynthetic process (GO:0006782)2.64041189
76negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63118727
77establishment of protein localization to mitochondrial membrane (GO:0090151)2.62619029
78microtubule depolymerization (GO:0007019)2.61632282
79kidney morphogenesis (GO:0060993)2.60893897
80embryonic epithelial tube formation (GO:0001838)2.59208311
81ncRNA catabolic process (GO:0034661)2.59148615
82intracellular protein transmembrane import (GO:0044743)2.58841393
83mitotic sister chromatid cohesion (GO:0007064)2.55431092
84purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.53718851
85negative regulation of neurotransmitter transport (GO:0051589)2.53111136
86mitochondrial DNA replication (GO:0006264)2.52184416
87protein complex biogenesis (GO:0070271)2.51640332
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48341558
89somatic recombination of immunoglobulin gene segments (GO:0016447)2.47412501
90peptidyl-lysine dimethylation (GO:0018027)2.46791286
91mechanosensory behavior (GO:0007638)2.45470478
92sensory perception of smell (GO:0007608)2.45214528
93intraciliary transport (GO:0042073)2.44250868
94photoreceptor cell maintenance (GO:0045494)2.43530807
95somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43278744
96somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43278744
97isotype switching (GO:0045190)2.43278744
98presynaptic membrane assembly (GO:0097105)2.40848630
99nephron tubule formation (GO:0072079)2.40522196
100reciprocal DNA recombination (GO:0035825)2.40510309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.14337511
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.76510346
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.34067706
4IGF1R_20145208_ChIP-Seq_DFB_Human3.13299045
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.12439490
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76403492
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76244052
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52367692
9GBX2_23144817_ChIP-Seq_PC3_Human2.44752435
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23902979
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.20696328
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20565810
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15781028
14IRF1_19129219_ChIP-ChIP_H3396_Human2.12520548
15FUS_26573619_Chip-Seq_HEK293_Human2.11183134
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07383826
17TAF15_26573619_Chip-Seq_HEK293_Human2.05700788
18ELK1_19687146_ChIP-ChIP_HELA_Human2.05383456
19EZH2_22144423_ChIP-Seq_EOC_Human2.04601302
20TP53_16413492_ChIP-PET_HCT116_Human2.04474339
21EWS_26573619_Chip-Seq_HEK293_Human1.98551625
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.98469789
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97116772
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93055228
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.92981582
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92608809
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85641790
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.85641790
29ER_23166858_ChIP-Seq_MCF-7_Human1.83174675
30P300_19829295_ChIP-Seq_ESCs_Human1.82550321
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.81116018
32VDR_22108803_ChIP-Seq_LS180_Human1.80460150
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77077759
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74361398
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.74024056
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72959830
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.71309723
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.70461550
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68371789
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65380701
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58580695
42CBP_20019798_ChIP-Seq_JUKART_Human1.58580695
43TCF4_23295773_ChIP-Seq_U87_Human1.57494235
44TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52947977
45STAT3_23295773_ChIP-Seq_U87_Human1.51847699
46E2F7_22180533_ChIP-Seq_HELA_Human1.51620246
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50823350
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50616230
49SMAD4_21799915_ChIP-Seq_A2780_Human1.47652858
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42003065
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37411719
52AR_21572438_ChIP-Seq_LNCaP_Human1.37074762
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36008424
54SOX9_26525672_Chip-Seq_HEART_Mouse1.34326283
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32102227
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30106511
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27840174
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27809397
59AR_25329375_ChIP-Seq_VCAP_Human1.27433713
60RUNX2_22187159_ChIP-Seq_PCA_Human1.27223581
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25216251
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21331410
63TCF4_22108803_ChIP-Seq_LS180_Human1.21040608
64RNF2_27304074_Chip-Seq_NSC_Mouse1.19923762
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19708445
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19647619
67AHR_22903824_ChIP-Seq_MCF-7_Human1.16923147
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.16201098
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16146960
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15773800
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14662725
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14372797
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.11031535
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.08154842
75MYC_18940864_ChIP-ChIP_HL60_Human1.06953158
76TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06742828
77SOX2_19829295_ChIP-Seq_ESCs_Human1.05854807
78NANOG_19829295_ChIP-Seq_ESCs_Human1.05854807
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04347386
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04237477
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04217934
82VDR_23849224_ChIP-Seq_CD4+_Human1.04182380
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.03815368
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02807609
85REST_21632747_ChIP-Seq_MESCs_Mouse1.02527446
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02505480
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.02355434
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00946078
89TP53_22573176_ChIP-Seq_HFKS_Human0.99925889
90FOXP3_21729870_ChIP-Seq_TREG_Human0.99553026
91E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99034893
92NCOR_22424771_ChIP-Seq_293T_Human0.97521301
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97316315
94STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97145883
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.96299857
96CDX2_22108803_ChIP-Seq_LS180_Human0.95509490
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95332494
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.94113986
99RXR_22108803_ChIP-Seq_LS180_Human0.92870004
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92433172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.49832906
2MP0003787_abnormal_imprinting4.27617258
3MP0002638_abnormal_pupillary_reflex3.70042430
4MP0000372_irregular_coat_pigmentation3.66715370
5MP0002163_abnormal_gland_morphology3.27945840
6MP0003123_paternal_imprinting2.99465987
7MP0001529_abnormal_vocalization2.91850326
8MP0008057_abnormal_DNA_replication2.80797549
9MP0010234_abnormal_vibrissa_follicle2.69051774
10MP0006276_abnormal_autonomic_nervous2.68580289
11MP0008995_early_reproductive_senescence2.53190006
12MP0002102_abnormal_ear_morphology2.52888616
13MP0002822_catalepsy2.50338030
14MP0008058_abnormal_DNA_repair2.41735060
15MP0004147_increased_porphyrin_level2.30302827
16MP0001188_hyperpigmentation2.27782565
17MP0008877_abnormal_DNA_methylation2.15556482
18MP0008872_abnormal_physiological_respon2.05483803
19MP0003136_yellow_coat_color2.02946867
20MP0005408_hypopigmentation1.85859898
21MP0005174_abnormal_tail_pigmentation1.77854863
22MP0003183_abnormal_peptide_metabolism1.77429177
23MP0000015_abnormal_ear_pigmentation1.76096506
24MP0005075_abnormal_melanosome_morpholog1.74522790
25MP0002090_abnormal_vision1.73852640
26MP0003880_abnormal_central_pattern1.71565611
27MP0003121_genomic_imprinting1.68023275
28MP0005551_abnormal_eye_electrophysiolog1.65545476
29MP0000778_abnormal_nervous_system1.61603473
30MP0005084_abnormal_gallbladder_morpholo1.61154847
31MP0005253_abnormal_eye_physiology1.59758904
32MP0005083_abnormal_biliary_tract1.57304597
33MP0002938_white_spotting1.56908245
34MP0003567_abnormal_fetal_cardiomyocyte1.56825274
35MP0005379_endocrine/exocrine_gland_phen1.54409069
36MP0009697_abnormal_copulation1.50646934
37MP0003646_muscle_fatigue1.48437549
38MP0000371_diluted_coat_color1.47640912
39MP0004924_abnormal_behavior1.47243568
40MP0005386_behavior/neurological_phenoty1.47243568
41MP0009046_muscle_twitch1.46915539
42MP0003786_premature_aging1.46680374
43MP0003890_abnormal_embryonic-extraembry1.40457237
44MP0003119_abnormal_digestive_system1.37826555
45MP0003718_maternal_effect1.34759796
46MP0006072_abnormal_retinal_apoptosis1.32900810
47MP0000427_abnormal_hair_cycle1.32619491
48MP0001986_abnormal_taste_sensitivity1.26920397
49MP0010678_abnormal_skin_adnexa1.26538759
50MP0006292_abnormal_olfactory_placode1.23509595
51MP0008007_abnormal_cellular_replicative1.23283593
52MP0002928_abnormal_bile_duct1.19873182
53MP0002653_abnormal_ependyma_morphology1.15973507
54MP0003656_abnormal_erythrocyte_physiolo1.15083862
55MP0001984_abnormal_olfaction1.13302874
56MP0001324_abnormal_eye_pigmentation1.04912103
57MP0005646_abnormal_pituitary_gland1.04905502
58MP0005670_abnormal_white_adipose1.00560121
59MP0001727_abnormal_embryo_implantation0.98358440
60MP0004043_abnormal_pH_regulation0.97870746
61MP0004381_abnormal_hair_follicle0.93871784
62MP0003111_abnormal_nucleus_morphology0.93094327
63MP0003943_abnormal_hepatobiliary_system0.92178126
64MP0002229_neurodegeneration0.91516721
65MP0005195_abnormal_posterior_eye0.91491277
66MP0002067_abnormal_sensory_capabilities0.88929107
67MP0001919_abnormal_reproductive_system0.88594748
68MP0005391_vision/eye_phenotype0.88270961
69MP0001485_abnormal_pinna_reflex0.88267018
70MP0004145_abnormal_muscle_electrophysio0.87618876
71MP0000647_abnormal_sebaceous_gland0.86988755
72MP0010094_abnormal_chromosome_stability0.86113755
73MP0003077_abnormal_cell_cycle0.84411449
74MP0004811_abnormal_neuron_physiology0.83995765
75MP0002095_abnormal_skin_pigmentation0.83132230
76MP0002075_abnormal_coat/hair_pigmentati0.82678596
77MP0005171_absent_coat_pigmentation0.81705449
78MP0002557_abnormal_social/conspecific_i0.76501396
79MP0002752_abnormal_somatic_nervous0.75834545
80MP0001486_abnormal_startle_reflex0.74595260
81MP0004742_abnormal_vestibular_system0.72399742
82MP0002882_abnormal_neuron_morphology0.71006553
83MP0001502_abnormal_circadian_rhythm0.69468740
84MP0000538_abnormal_urinary_bladder0.68598496
85MP0000383_abnormal_hair_follicle0.67629899
86MP0001968_abnormal_touch/_nociception0.67572950
87MP0002909_abnormal_adrenal_gland0.67420421
88MP0001970_abnormal_pain_threshold0.67242548
89MP0002210_abnormal_sex_determination0.67014512
90MP0004085_abnormal_heartbeat0.66598532
91MP0003252_abnormal_bile_duct0.66098978
92MP0001286_abnormal_eye_development0.65672851
93MP0002396_abnormal_hematopoietic_system0.65551457
94MP0002282_abnormal_trachea_morphology0.65455359
95MP0001293_anophthalmia0.65203058
96MP0002160_abnormal_reproductive_system0.63920910
97MP0009745_abnormal_behavioral_response0.63506606
98MP0001186_pigmentation_phenotype0.63367051
99MP0005389_reproductive_system_phenotype0.62229200
100MP0002735_abnormal_chemical_nociception0.60905082

Predicted human phenotypes

RankGene SetZ-score
1Diastasis recti (HP:0001540)5.80595645
2Carpal bone hypoplasia (HP:0001498)4.25352559
3Ependymoma (HP:0002888)4.05916287
4Neoplasm of the adrenal cortex (HP:0100641)3.73970614
5Abnormal biliary tract physiology (HP:0012439)3.67574450
6Bile duct proliferation (HP:0001408)3.67574450
7Abnormal pancreas size (HP:0012094)3.39419306
8Hip dysplasia (HP:0001385)3.25619361
911 pairs of ribs (HP:0000878)3.14063520
10Volvulus (HP:0002580)3.08306093
11Abnormality of macular pigmentation (HP:0008002)3.05031489
12Abnormality of the astrocytes (HP:0100707)3.03984096
13Astrocytoma (HP:0009592)3.03984096
14Glioma (HP:0009733)2.95968093
15Pancreatic cysts (HP:0001737)2.94160080
16Abnormality of the renal cortex (HP:0011035)2.82142391
17Thyroiditis (HP:0100646)2.77386238
18Hyperventilation (HP:0002883)2.76662625
19True hermaphroditism (HP:0010459)2.75875903
20Albinism (HP:0001022)2.71449680
21Fair hair (HP:0002286)2.66292894
22Pancreatic fibrosis (HP:0100732)2.62345326
23Metaphyseal dysplasia (HP:0100255)2.59470082
24Progressive cerebellar ataxia (HP:0002073)2.58441249
25Bony spicule pigmentary retinopathy (HP:0007737)2.52613796
26Hepatoblastoma (HP:0002884)2.48758563
27Broad alveolar ridges (HP:0000187)2.48065224
28Lissencephaly (HP:0001339)2.42894796
29Drooling (HP:0002307)2.39268921
30Tubulointerstitial nephritis (HP:0001970)2.37845085
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.37607444
32Severe combined immunodeficiency (HP:0004430)2.30999830
33Nephrogenic diabetes insipidus (HP:0009806)2.28575981
34Absent eyebrow (HP:0002223)2.27616451
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.26061678
36Curly hair (HP:0002212)2.25298823
37Aqueductal stenosis (HP:0002410)2.25294070
38Protruding tongue (HP:0010808)2.24804885
39Gaze-evoked nystagmus (HP:0000640)2.24658454
40Adrenal hypoplasia (HP:0000835)2.23986653
41Sparse lateral eyebrow (HP:0005338)2.22967873
42Generalized hypopigmentation of hair (HP:0011358)2.18620925
43Renal cortical cysts (HP:0000803)2.16099656
44Limb hypertonia (HP:0002509)2.13880408
45Anophthalmia (HP:0000528)2.13720961
46Excessive salivation (HP:0003781)2.13418748
47Genetic anticipation (HP:0003743)2.11648645
48Hypoplastic iliac wings (HP:0002866)2.11084942
49Disproportionate short-trunk short stature (HP:0003521)2.09097135
50Concave nail (HP:0001598)2.06970924
51Stomach cancer (HP:0012126)2.05938061
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04934395
53Chronic hepatic failure (HP:0100626)2.04618743
54Bifid tongue (HP:0010297)2.00947735
55Chorioretinal atrophy (HP:0000533)1.99290688
56Generalized hypopigmentation (HP:0007513)1.97627033
57Overgrowth (HP:0001548)1.97233714
58Hypoplastic labia majora (HP:0000059)1.96281103
59Abnormal rod and cone electroretinograms (HP:0008323)1.96054544
60Pachygyria (HP:0001302)1.95278587
61Lip pit (HP:0100267)1.93087051
62Abnormality of lateral ventricle (HP:0030047)1.92259247
63Wide intermamillary distance (HP:0006610)1.89282041
64Neonatal hypoglycemia (HP:0001998)1.87983861
65Fibular hypoplasia (HP:0003038)1.87390449
66Medial flaring of the eyebrow (HP:0010747)1.86678055
67Breast carcinoma (HP:0003002)1.83782785
68Renal hypoplasia (HP:0000089)1.83523991
69Birth length less than 3rd percentile (HP:0003561)1.83200227
70Absent speech (HP:0001344)1.82414218
71Abolished electroretinogram (ERG) (HP:0000550)1.82142115
72Widely spaced teeth (HP:0000687)1.81672069
73Neoplasm of the tracheobronchial system (HP:0100552)1.81668199
74Alveolar cell carcinoma (HP:0006519)1.81204436
75Broad-based gait (HP:0002136)1.79969467
763-Methylglutaconic aciduria (HP:0003535)1.79555781
77Vaginal atresia (HP:0000148)1.77499996
78Sloping forehead (HP:0000340)1.77434922
79Genital tract atresia (HP:0001827)1.77251930
80Supernumerary spleens (HP:0009799)1.76802911
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.76518340
82Abnormality of midbrain morphology (HP:0002418)1.76429930
83Molar tooth sign on MRI (HP:0002419)1.76429930
84Abnormality of dental color (HP:0011073)1.76283103
85Decreased central vision (HP:0007663)1.75152504
86Abnormality of the labia majora (HP:0012881)1.75133138
87Tented upper lip vermilion (HP:0010804)1.74383873
88Cystic liver disease (HP:0006706)1.74290745
89Abnormality of B cell number (HP:0010975)1.73615973
90Gait imbalance (HP:0002141)1.73347049
91Enlarged kidneys (HP:0000105)1.72047800
92Agnosia (HP:0010524)1.71611832
93B lymphocytopenia (HP:0010976)1.71236430
94Medulloblastoma (HP:0002885)1.70633735
95Cone-rod dystrophy (HP:0000548)1.70083248
96Severe Myopia (HP:0011003)1.69873321
97Decreased circulating renin level (HP:0003351)1.69756286
98Rhabdomyosarcoma (HP:0002859)1.68957168
99Biliary tract neoplasm (HP:0100574)1.68717419
100Astigmatism (HP:0000483)1.68285530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.36721938
2NTRK33.34657306
3FRK3.17633186
4MARK13.15487976
5MST43.00201439
6BMPR1B2.76532351
7NUAK12.67856909
8STK162.60548491
9ACVR1B2.52104158
10MAP3K122.47624048
11ZAK2.45300878
12DYRK32.26111422
13EIF2AK32.18183413
14BCR1.90791067
15TNIK1.85680286
16BRSK21.81325188
17CAMKK21.73660711
18FLT31.68411536
19MINK11.51235517
20MKNK21.43517704
21SRPK11.32495176
22DYRK21.25366083
23PDK21.22434534
24SGK21.21296653
25LATS11.20138691
26MAP3K141.19848527
27CASK1.19119081
28WNK31.11318265
29TRIM281.09642892
30INSRR1.09624592
31EIF2AK11.05615519
32SIK21.03558633
33MAP3K21.01341273
34MAP3K40.96720653
35GRK70.94751427
36OXSR10.94723293
37SIK30.92223199
38CDC70.91692227
39BRD40.91353062
40ATM0.86542283
41CSNK1G20.86526694
42MAPK130.86011618
43SGK2230.85298604
44SGK4940.85298604
45PNCK0.84607673
46DYRK1A0.84593575
47TGFBR10.83390270
48TYRO30.81603744
49CAMK1G0.76604008
50WEE10.74797894
51CSNK1A1L0.74397624
52IRAK10.73232923
53GRK10.73010812
54PIK3CA0.72400750
55STK390.72273512
56PAK30.71888812
57AKT30.71371771
58EPHA40.67995188
59MAP2K70.67528121
60STK30.66835303
61CAMK10.66267016
62CSNK1G30.66162700
63ERBB20.64876197
64FGFR20.63423913
65CSNK1E0.63042921
66CSNK1G10.60306298
67PIK3CG0.60288134
68MKNK10.59816625
69BRSK10.59047459
70ERBB30.58979967
71MAP2K40.58926271
72FER0.58297499
73PLK30.58167268
74CAMK40.56932216
75CLK10.56336672
76NME10.55814199
77ATR0.55656561
78MAP3K100.55476026
79CCNB10.55198108
80PLK10.55101011
81DMPK0.53069464
82YES10.52636733
83BCKDK0.52137759
84CDK190.51869794
85CSNK1D0.50399162
86PRKCH0.48353385
87CSNK1A10.45202423
88BMPR20.44330464
89EPHA30.44126302
90SGK10.43445465
91MARK30.42319433
92TEC0.40625638
93MATK0.39054290
94CDK30.38916981
95PRKACB0.38909659
96CDK50.38193630
97MAPK80.37411170
98PRKDC0.37358981
99CHEK20.35515563
100SGK30.33884320

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.67554334
2Non-homologous end-joining_Homo sapiens_hsa034503.31445600
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.99328144
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.84095167
5Protein export_Homo sapiens_hsa030602.78064984
6Steroid biosynthesis_Homo sapiens_hsa001002.75034679
7Homologous recombination_Homo sapiens_hsa034402.55392637
8Nitrogen metabolism_Homo sapiens_hsa009102.23759869
9Fanconi anemia pathway_Homo sapiens_hsa034602.17217781
10Phototransduction_Homo sapiens_hsa047442.12970858
11RNA degradation_Homo sapiens_hsa030181.96972229
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90991004
13Lysine degradation_Homo sapiens_hsa003101.87349368
14Selenocompound metabolism_Homo sapiens_hsa004501.77484999
15Parkinsons disease_Homo sapiens_hsa050121.72865637
16Cocaine addiction_Homo sapiens_hsa050301.68063830
17DNA replication_Homo sapiens_hsa030301.61086530
18Propanoate metabolism_Homo sapiens_hsa006401.60719119
19Caffeine metabolism_Homo sapiens_hsa002321.56364935
20Cell cycle_Homo sapiens_hsa041101.54947945
21Olfactory transduction_Homo sapiens_hsa047401.53619566
22Tryptophan metabolism_Homo sapiens_hsa003801.51373588
23Basal transcription factors_Homo sapiens_hsa030221.49312142
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46784218
25Nucleotide excision repair_Homo sapiens_hsa034201.43260617
26Butanoate metabolism_Homo sapiens_hsa006501.42824495
27RNA polymerase_Homo sapiens_hsa030201.42414294
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41882207
29Oxidative phosphorylation_Homo sapiens_hsa001901.37740600
30mRNA surveillance pathway_Homo sapiens_hsa030151.27821286
31Colorectal cancer_Homo sapiens_hsa052101.24955487
32RNA transport_Homo sapiens_hsa030131.23270007
33Thyroid cancer_Homo sapiens_hsa052161.20506465
34Circadian rhythm_Homo sapiens_hsa047101.09647604
35Dopaminergic synapse_Homo sapiens_hsa047281.08538013
36Basal cell carcinoma_Homo sapiens_hsa052171.08531942
37One carbon pool by folate_Homo sapiens_hsa006701.07681526
38Huntingtons disease_Homo sapiens_hsa050161.05919063
39Fatty acid biosynthesis_Homo sapiens_hsa000611.05871584
40Base excision repair_Homo sapiens_hsa034101.05006416
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02916839
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.99533240
43Cholinergic synapse_Homo sapiens_hsa047250.96383757
44Alcoholism_Homo sapiens_hsa050340.94440084
45Proteasome_Homo sapiens_hsa030500.94400134
46Nicotine addiction_Homo sapiens_hsa050330.92625127
47Taste transduction_Homo sapiens_hsa047420.91553867
48Hedgehog signaling pathway_Homo sapiens_hsa043400.90626308
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90382073
50Linoleic acid metabolism_Homo sapiens_hsa005910.86294470
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85242592
52Long-term depression_Homo sapiens_hsa047300.84769991
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84382924
54Prostate cancer_Homo sapiens_hsa052150.83914352
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78846003
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77914014
57Amphetamine addiction_Homo sapiens_hsa050310.77201395
58Melanogenesis_Homo sapiens_hsa049160.73700473
59Alzheimers disease_Homo sapiens_hsa050100.73018443
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70878346
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70254356
62Peroxisome_Homo sapiens_hsa041460.66190424
63Purine metabolism_Homo sapiens_hsa002300.65169915
64Glutamatergic synapse_Homo sapiens_hsa047240.64926499
65Circadian entrainment_Homo sapiens_hsa047130.61184704
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60658798
67Hippo signaling pathway_Homo sapiens_hsa043900.59826818
68Type II diabetes mellitus_Homo sapiens_hsa049300.59125751
69Serotonergic synapse_Homo sapiens_hsa047260.59055108
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57056588
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.56489440
72Ovarian steroidogenesis_Homo sapiens_hsa049130.55556847
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55420055
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55003823
75Wnt signaling pathway_Homo sapiens_hsa043100.54893236
76Dorso-ventral axis formation_Homo sapiens_hsa043200.53017297
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51671186
78cAMP signaling pathway_Homo sapiens_hsa040240.51327653
79Endometrial cancer_Homo sapiens_hsa052130.50891586
80Axon guidance_Homo sapiens_hsa043600.48506463
81Ether lipid metabolism_Homo sapiens_hsa005650.46749560
82Spliceosome_Homo sapiens_hsa030400.45025686
83Regulation of autophagy_Homo sapiens_hsa041400.44724981
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44323033
85Insulin secretion_Homo sapiens_hsa049110.44140710
86Collecting duct acid secretion_Homo sapiens_hsa049660.43191003
87Acute myeloid leukemia_Homo sapiens_hsa052210.42748827
88Morphine addiction_Homo sapiens_hsa050320.41170405
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40311489
90p53 signaling pathway_Homo sapiens_hsa041150.39154245
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39060958
92Metabolic pathways_Homo sapiens_hsa011000.35356149
93FoxO signaling pathway_Homo sapiens_hsa040680.35267680
94Fatty acid metabolism_Homo sapiens_hsa012120.32762725
95Adherens junction_Homo sapiens_hsa045200.32329517
96Pyrimidine metabolism_Homo sapiens_hsa002400.30935790
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28280753
98Calcium signaling pathway_Homo sapiens_hsa040200.28163410
99Oocyte meiosis_Homo sapiens_hsa041140.27816139
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27291724

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