HMGN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)6.47071987
2DNA unwinding involved in DNA replication (GO:0006268)6.41434922
3DNA strand elongation (GO:0022616)6.20557715
4telomere maintenance via semi-conservative replication (GO:0032201)6.12278491
5telomere maintenance via recombination (GO:0000722)5.44288269
6DNA replication initiation (GO:0006270)5.34310435
7mitotic recombination (GO:0006312)5.28544027
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.97889011
9nucleotide-excision repair, DNA gap filling (GO:0006297)4.67845089
10CENP-A containing nucleosome assembly (GO:0034080)4.63386183
11kinetochore organization (GO:0051383)4.49162440
12telomere maintenance via telomere lengthening (GO:0010833)4.48814803
13DNA replication checkpoint (GO:0000076)4.47397292
14chromatin remodeling at centromere (GO:0031055)4.45383606
15translesion synthesis (GO:0019985)4.41899003
16DNA replication-independent nucleosome organization (GO:0034724)4.18632927
17DNA replication-independent nucleosome assembly (GO:0006336)4.18632927
18kinetochore assembly (GO:0051382)4.15075782
19DNA topological change (GO:0006265)4.14330260
20DNA ligation (GO:0006266)4.07316903
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.03093085
22DNA deamination (GO:0045006)4.02691218
23protein localization to kinetochore (GO:0034501)4.02621527
24deoxyribonucleotide biosynthetic process (GO:0009263)4.01336826
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96047525
26mitotic metaphase plate congression (GO:0007080)3.88130038
27proteasome assembly (GO:0043248)3.86602426
28negative regulation of RNA splicing (GO:0033119)3.82932520
29protein localization to chromosome, centromeric region (GO:0071459)3.81160550
30mitotic chromosome condensation (GO:0007076)3.80532303
31mitotic sister chromatid segregation (GO:0000070)3.72989775
32attachment of spindle microtubules to kinetochore (GO:0008608)3.72069621
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71375713
34ribosomal small subunit assembly (GO:0000028)3.66989278
35viral mRNA export from host cell nucleus (GO:0046784)3.66801043
36deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.64211288
37histone exchange (GO:0043486)3.64066997
38sister chromatid segregation (GO:0000819)3.63188751
39establishment of integrated proviral latency (GO:0075713)3.61818706
40postreplication repair (GO:0006301)3.60822699
41DNA replication-dependent nucleosome assembly (GO:0006335)3.55334782
42DNA replication-dependent nucleosome organization (GO:0034723)3.55334782
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51476361
44establishment of viral latency (GO:0019043)3.50698062
45metaphase plate congression (GO:0051310)3.50252872
46deoxyribose phosphate biosynthetic process (GO:0046385)3.44549847
472-deoxyribonucleotide biosynthetic process (GO:0009265)3.44549847
48establishment of chromosome localization (GO:0051303)3.42214618
49mismatch repair (GO:0006298)3.41735645
50spliceosomal complex assembly (GO:0000245)3.40912147
51non-recombinational repair (GO:0000726)3.38397517
52double-strand break repair via nonhomologous end joining (GO:0006303)3.38397517
53negative regulation of mRNA processing (GO:0050686)3.37749949
54replication fork processing (GO:0031297)3.35215953
55regulation of mitochondrial translation (GO:0070129)3.34723026
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.33535937
57telomere maintenance (GO:0000723)3.32692944
58microtubule depolymerization (GO:0007019)3.32383632
59telomere organization (GO:0032200)3.31759231
60base-excision repair (GO:0006284)3.29774786
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29454141
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29454141
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29454141
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28642748
65negative regulation of sister chromatid segregation (GO:0033046)3.28642748
66negative regulation of mitotic sister chromatid separation (GO:2000816)3.28642748
67negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28642748
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28142882
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25370012
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25370012
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25051052
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24542822
73negative regulation of chromosome segregation (GO:0051985)3.23883432
74DNA double-strand break processing (GO:0000729)3.22842838
75negative regulation of oligodendrocyte differentiation (GO:0048715)3.22341274
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.22332107
77spindle assembly checkpoint (GO:0071173)3.21620054
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21097571
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19687538
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.19687538
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.19451569
82DNA catabolic process, exonucleolytic (GO:0000738)3.18977172
83mitotic spindle assembly checkpoint (GO:0007094)3.18584631
84protein K6-linked ubiquitination (GO:0085020)3.18019519
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.17906185
86nucleobase biosynthetic process (GO:0046112)3.17860511
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17725036
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17589756
89V(D)J recombination (GO:0033151)3.15647306
90cullin deneddylation (GO:0010388)3.14935437
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13087909
92energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12847867
93ATP synthesis coupled proton transport (GO:0015986)3.12847867
94G1/S transition of mitotic cell cycle (GO:0000082)3.10409246
95cell cycle G1/S phase transition (GO:0044843)3.10409246
96regulation of chromosome segregation (GO:0051983)3.10265750
97regulation of cellular amino acid metabolic process (GO:0006521)3.10261138
98termination of RNA polymerase II transcription (GO:0006369)3.10058102
99negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.08686999
100negative regulation of DNA-templated transcription, elongation (GO:0032785)3.08686999
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.07753259
102ATP-dependent chromatin remodeling (GO:0043044)3.07426114
103spindle checkpoint (GO:0031577)3.06650387
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06534516
105transcription-coupled nucleotide-excision repair (GO:0006283)3.06424551
106resolution of meiotic recombination intermediates (GO:0000712)3.06362436
107mRNA splicing, via spliceosome (GO:0000398)3.05603795
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.05603795
109pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05389876
110regulation of spindle organization (GO:0090224)3.05345037
111positive regulation of ligase activity (GO:0051351)3.04639329
112purine nucleobase biosynthetic process (GO:0009113)3.02767222
113mitotic cell cycle (GO:0000278)3.02554264
114protein deneddylation (GO:0000338)3.02049064
115chromosome segregation (GO:0007059)3.01882981
116spliceosomal snRNP assembly (GO:0000387)3.01874285
117dosage compensation (GO:0007549)3.01126601
118RNA splicing, via transesterification reactions (GO:0000375)3.01114585
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00756188
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00158890
121DNA strand renaturation (GO:0000733)2.99926229
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99619052
123histone H2A acetylation (GO:0043968)2.98526716
124DNA duplex unwinding (GO:0032508)2.95298835
125mitotic nuclear envelope disassembly (GO:0007077)2.94686940
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93742809
127negative regulation of ligase activity (GO:0051352)2.93645800
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93645800
129DNA geometric change (GO:0032392)2.93269676
130regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91737734
131DNA synthesis involved in DNA repair (GO:0000731)2.90105779
132mitotic spindle checkpoint (GO:0071174)2.89955508
133chromatin assembly or disassembly (GO:0006333)2.85804498
134meiotic chromosome segregation (GO:0045132)2.83595701
135regulation of sister chromatid segregation (GO:0033045)2.82723563
136regulation of mitotic sister chromatid separation (GO:0010965)2.82723563
137regulation of mitotic sister chromatid segregation (GO:0033047)2.82723563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.54300651
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.26706208
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.91555937
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.64865630
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53045443
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45089725
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86850009
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86261688
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76569677
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.74743767
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.66598266
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57645392
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51939935
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49899351
15XRN2_22483619_ChIP-Seq_HELA_Human2.48511841
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46131886
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.41181556
18AR_21909140_ChIP-Seq_LNCAP_Human2.36916338
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35433035
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27182009
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.20056369
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18132980
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08212600
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05694370
25VDR_23849224_ChIP-Seq_CD4+_Human2.00851400
26E2F7_22180533_ChIP-Seq_HELA_Human11.5239573
27CIITA_25753668_ChIP-Seq_RAJI_Human1.98172543
28FOXP3_21729870_ChIP-Seq_TREG_Human1.93339015
29DCP1A_22483619_ChIP-Seq_HELA_Human1.93315045
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91384546
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90429322
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82899921
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80865632
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80745076
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80702143
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79301620
37* TTF2_22483619_ChIP-Seq_HELA_Human1.77792960
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76206148
39GABP_19822575_ChIP-Seq_HepG2_Human1.75613330
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73454448
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72994010
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71159577
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69917013
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.63881106
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.62135804
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57682628
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53083481
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52861785
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49175324
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46983594
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44916027
52ELK1_19687146_ChIP-ChIP_HELA_Human1.41971108
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38843072
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.35973898
55VDR_21846776_ChIP-Seq_THP-1_Human1.35685626
56MYC_22102868_ChIP-Seq_BL_Human1.31718358
57* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28939519
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28044429
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.27453419
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27210900
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26457209
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25687676
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25500721
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24041467
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23420190
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22434394
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20785331
68* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17824523
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15345601
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15333456
71* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12815192
72KDM5A_27292631_Chip-Seq_BREAST_Human1.11968436
73ZNF274_21170338_ChIP-Seq_K562_Hela1.11484081
74EWS_26573619_Chip-Seq_HEK293_Human1.11361124
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.06479680
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04788379
77IRF1_19129219_ChIP-ChIP_H3396_Human1.04308161
78MYC_18940864_ChIP-ChIP_HL60_Human0.99629204
79RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97932193
80SPI1_23547873_ChIP-Seq_NB4_Human0.97679982
81SCL_19346495_ChIP-Seq_HPC-7_Human0.96786471
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94554026
83IGF1R_20145208_ChIP-Seq_DFB_Human0.92738971
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92375280
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91113212
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90305787
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86879710
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83568153
89TFEB_21752829_ChIP-Seq_HELA_Human0.82634166
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81829233
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80506099
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79556100
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.79264227
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78901807
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77961430
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.75825664
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75146259
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73968050
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73737964
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73472073
101* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72827006
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.71778623
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.71604753
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68582482
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68311768
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.67172981
107VDR_24763502_ChIP-Seq_THP-1_Human0.66068559
108FUS_26573619_Chip-Seq_HEK293_Human0.63526918
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63340658
110CTCF_18555785_ChIP-Seq_MESCs_Mouse0.62920764
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.62327273
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.61905920
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.60154627
114VDR_22108803_ChIP-Seq_LS180_Human0.57729839
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.57450819
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.57354558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.94943128
2MP0003693_abnormal_embryo_hatching4.73661003
3MP0003077_abnormal_cell_cycle4.04361141
4MP0003111_abnormal_nucleus_morphology3.85224666
5MP0004957_abnormal_blastocyst_morpholog3.50215768
6MP0008057_abnormal_DNA_replication3.48148894
7MP0008058_abnormal_DNA_repair3.20566659
8MP0008007_abnormal_cellular_replicative3.18203315
9MP0010030_abnormal_orbit_morphology2.80429235
10MP0008932_abnormal_embryonic_tissue2.68956460
11MP0000566_synostosis2.45058282
12MP0000372_irregular_coat_pigmentation2.20852973
13MP0003718_maternal_effect2.07585645
14MP0003315_abnormal_perineum_morphology2.06147312
15MP0004147_increased_porphyrin_level2.04100237
16MP0009697_abnormal_copulation2.03569012
17MP0002653_abnormal_ependyma_morphology1.96608276
18MP0006054_spinal_hemorrhage1.92010312
19MP0002396_abnormal_hematopoietic_system1.90685836
20MP0000350_abnormal_cell_proliferation1.88973581
21MP0006036_abnormal_mitochondrial_physio1.87474268
22MP0002102_abnormal_ear_morphology1.85148944
23MP0001529_abnormal_vocalization1.80323360
24MP0004808_abnormal_hematopoietic_stem1.79313140
25MP0000490_abnormal_crypts_of1.76233502
26MP0002234_abnormal_pharynx_morphology1.76206445
27MP0002282_abnormal_trachea_morphology1.75958820
28MP0003806_abnormal_nucleotide_metabolis1.72856650
29MP0006292_abnormal_olfactory_placode1.72153495
30MP0001730_embryonic_growth_arrest1.71096381
31MP0006072_abnormal_retinal_apoptosis1.67951885
32MP0005499_abnormal_olfactory_system1.65121317
33MP0005394_taste/olfaction_phenotype1.65121317
34MP0002938_white_spotting1.62493560
35MP0003283_abnormal_digestive_organ1.62422979
36MP0006035_abnormal_mitochondrial_morpho1.58585926
37MP0008877_abnormal_DNA_methylation1.56874732
38MP0003786_premature_aging1.52030265
39MP0000049_abnormal_middle_ear1.50706015
40MP0003123_paternal_imprinting1.42617964
41MP0004133_heterotaxia1.41106325
42MP0000313_abnormal_cell_death1.38494682
43MP0009053_abnormal_anal_canal1.37828478
44MP0000537_abnormal_urethra_morphology1.37418255
45MP0001764_abnormal_homeostasis1.34396955
46MP0002019_abnormal_tumor_incidence1.29229152
47MP0009379_abnormal_foot_pigmentation1.27195092
48MP0002751_abnormal_autonomic_nervous1.27082699
49MP0003186_abnormal_redox_activity1.25570037
50MP0001697_abnormal_embryo_size1.25398149
51MP0003763_abnormal_thymus_physiology1.24158471
52MP0002085_abnormal_embryonic_tissue1.20921363
53MP0002080_prenatal_lethality1.17316604
54MP0002095_abnormal_skin_pigmentation1.16456803
55MP0000703_abnormal_thymus_morphology1.15146380
56MP0001293_anophthalmia1.14389365
57MP0003121_genomic_imprinting1.14372177
58MP0002398_abnormal_bone_marrow1.07946304
59MP0005253_abnormal_eye_physiology1.07725243
60MP0003136_yellow_coat_color1.07717994
61MP0010307_abnormal_tumor_latency1.07060822
62MP0005174_abnormal_tail_pigmentation1.06155676
63MP0003943_abnormal_hepatobiliary_system1.06139545
64MP0000358_abnormal_cell_content/1.05790075
65MP0008789_abnormal_olfactory_epithelium1.02914211
66MP0002932_abnormal_joint_morphology1.00658312
67MP0003890_abnormal_embryonic-extraembry1.00376617
68MP0005380_embryogenesis_phenotype0.98795120
69MP0001672_abnormal_embryogenesis/_devel0.98795120
70MP0005084_abnormal_gallbladder_morpholo0.98112526
71MP0002210_abnormal_sex_determination0.98093973
72MP0008995_early_reproductive_senescence0.97977674
73MP0002429_abnormal_blood_cell0.93716076
74MP0002084_abnormal_developmental_patter0.93515625
75MP0005645_abnormal_hypothalamus_physiol0.93213869
76MP0002722_abnormal_immune_system0.92733356
77MP0001919_abnormal_reproductive_system0.92388192
78MP0005076_abnormal_cell_differentiation0.92365704
79MP0000631_abnormal_neuroendocrine_gland0.92044830
80MP0002233_abnormal_nose_morphology0.91958308
81MP0005075_abnormal_melanosome_morpholog0.89908005
82MP0003567_abnormal_fetal_cardiomyocyte0.88975871
83MP0003984_embryonic_growth_retardation0.88222274
84MP0003698_abnormal_male_reproductive0.87727487
85MP0000383_abnormal_hair_follicle0.87534194
86MP0002249_abnormal_larynx_morphology0.87201997
87MP0002163_abnormal_gland_morphology0.85719666
88MP0002160_abnormal_reproductive_system0.85205458
89MP0001346_abnormal_lacrimal_gland0.84994182
90MP0002088_abnormal_embryonic_growth/wei0.84708086
91MP0001270_distended_abdomen0.84384097
92MP0000689_abnormal_spleen_morphology0.84330687
93MP0009333_abnormal_splenocyte_physiolog0.83852975
94MP0005671_abnormal_response_to0.83812036
95MP0001727_abnormal_embryo_implantation0.83572626
96MP0001119_abnormal_female_reproductive0.83092693
97MP0001145_abnormal_male_reproductive0.82920112
98MP0003938_abnormal_ear_development0.82176173
99MP0003115_abnormal_respiratory_system0.80483707
100MP0000716_abnormal_immune_system0.79844969
101MP0003646_muscle_fatigue0.79583354
102MP0002075_abnormal_coat/hair_pigmentati0.79144256
103MP0000465_gastrointestinal_hemorrhage0.79085535
104MP0001929_abnormal_gametogenesis0.76574888
105MP0002092_abnormal_eye_morphology0.76004007
106MP0004197_abnormal_fetal_growth/weight/0.75451453
107MP0002111_abnormal_tail_morphology0.73986014
108MP0009785_altered_susceptibility_to0.73117481
109MP0010352_gastrointestinal_tract_polyps0.72929050
110MP0005220_abnormal_exocrine_pancreas0.72132005
111MP0003861_abnormal_nervous_system0.71832683
112MP0002736_abnormal_nociception_after0.70540515
113MP0001286_abnormal_eye_development0.69975593
114MP0003937_abnormal_limbs/digits/tail_de0.69103264
115MP0002098_abnormal_vibrissa_morphology0.68173427
116MP0002090_abnormal_vision0.67676578
117MP0008872_abnormal_physiological_respon0.67584413
118MP0000685_abnormal_immune_system0.67497163
119MP0005391_vision/eye_phenotype0.67193092
120MP0002116_abnormal_craniofacial_bone0.67137595
121MP0005171_absent_coat_pigmentation0.66997203
122MP0005397_hematopoietic_system_phenotyp0.65853103
123MP0001545_abnormal_hematopoietic_system0.65853103
124MP0005248_abnormal_Harderian_gland0.65834917
125MP0002420_abnormal_adaptive_immunity0.64595592
126MP0005389_reproductive_system_phenotype0.64134478
127MP0000428_abnormal_craniofacial_morphol0.63757076
128MP0000653_abnormal_sex_gland0.62795604
129MP0001819_abnormal_immune_cell0.62406787
130MP0002161_abnormal_fertility/fecundity0.62012513
131MP0005646_abnormal_pituitary_gland0.59953592
132MP0002009_preneoplasia0.59235846
133MP0009672_abnormal_birth_weight0.59220028
134MP0005408_hypopigmentation0.56750580
135MP0003787_abnormal_imprinting0.56647703
136MP0000647_abnormal_sebaceous_gland0.55929051
137MP0002822_catalepsy0.54606320

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.03056810
2Birth length less than 3rd percentile (HP:0003561)3.96895863
3Acute necrotizing encephalopathy (HP:0006965)3.74399470
4Abnormal number of incisors (HP:0011064)3.73138994
511 pairs of ribs (HP:0000878)3.61341558
6Abnormal mitochondria in muscle tissue (HP:0008316)3.52365966
7Degeneration of anterior horn cells (HP:0002398)3.51581886
8Abnormality of the anterior horn cell (HP:0006802)3.51581886
9Mitochondrial inheritance (HP:0001427)3.44091670
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43656289
11Chromsome breakage (HP:0040012)3.41955578
12Acute encephalopathy (HP:0006846)3.40439206
13Oral leukoplakia (HP:0002745)3.39899792
14Hepatocellular necrosis (HP:0001404)3.37135629
15Colon cancer (HP:0003003)3.33783243
16Patellar aplasia (HP:0006443)3.30287780
17Increased CSF lactate (HP:0002490)3.24438473
18Hepatic necrosis (HP:0002605)3.18285765
19Aplastic anemia (HP:0001915)3.16364314
20Pendular nystagmus (HP:0012043)3.05370085
21Aplasia/Hypoplasia of the patella (HP:0006498)3.03105575
22Progressive macrocephaly (HP:0004481)2.96546420
23Abnormality of the labia minora (HP:0012880)2.91274864
24Increased hepatocellular lipid droplets (HP:0006565)2.90254617
25Abnormal number of erythroid precursors (HP:0012131)2.89175759
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.86683654
27Lipid accumulation in hepatocytes (HP:0006561)2.79808528
28Abnormality of chromosome stability (HP:0003220)2.79578224
29Abnormality of cells of the erythroid lineage (HP:0012130)2.79483203
30Microvesicular hepatic steatosis (HP:0001414)2.78415165
31Ectopic kidney (HP:0000086)2.71431676
32Small intestinal stenosis (HP:0012848)2.69199001
33Duodenal stenosis (HP:0100867)2.69199001
34Abnormality of the ileum (HP:0001549)2.68582943
35Selective tooth agenesis (HP:0001592)2.65604974
36Cerebral edema (HP:0002181)2.62849871
37Short middle phalanx of the 5th finger (HP:0004220)2.61350922
38Meckel diverticulum (HP:0002245)2.59361722
39Hypoplasia of the capital femoral epiphysis (HP:0003090)2.58911708
40Increased serum lactate (HP:0002151)2.58882890
41Microretrognathia (HP:0000308)2.58736082
42IgM deficiency (HP:0002850)2.51636063
43Increased nuchal translucency (HP:0010880)2.49858088
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48499846
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48499846
46Intestinal atresia (HP:0011100)2.46130481
47Medulloblastoma (HP:0002885)2.45607100
48Abnormality of the duodenum (HP:0002246)2.45572477
49Abnormality of the preputium (HP:0100587)2.44816729
50Lactic acidosis (HP:0003128)2.43565654
51Breast hypoplasia (HP:0003187)2.40999840
52Clubbing of toes (HP:0100760)2.40946574
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40263112
54Severe visual impairment (HP:0001141)2.36160787
55Abnormal lung lobation (HP:0002101)2.34237054
56Increased serum pyruvate (HP:0003542)2.32733387
57Type I transferrin isoform profile (HP:0003642)2.32570294
58Neoplasm of the pancreas (HP:0002894)2.32239837
59Duplicated collecting system (HP:0000081)2.31548746
60True hermaphroditism (HP:0010459)2.31049838
61Glossoptosis (HP:0000162)2.28607508
62Nephroblastoma (Wilms tumor) (HP:0002667)2.26469077
63Premature graying of hair (HP:0002216)2.25659747
64Optic nerve coloboma (HP:0000588)2.25124777
65Combined immunodeficiency (HP:0005387)2.24564281
66Myelodysplasia (HP:0002863)2.24521229
67Abnormality of the renal collecting system (HP:0004742)2.24445628
683-Methylglutaconic aciduria (HP:0003535)2.23405112
69Hyperglycinemia (HP:0002154)2.22142457
70Agnosia (HP:0010524)2.22095822
71Pancreatic cysts (HP:0001737)2.21400436
72Triphalangeal thumb (HP:0001199)2.20429875
73Bone marrow hypocellularity (HP:0005528)2.19906884
74Increased intramyocellular lipid droplets (HP:0012240)2.19392186
75Reduced antithrombin III activity (HP:0001976)2.15793701
76Molar tooth sign on MRI (HP:0002419)2.14292986
77Abnormality of midbrain morphology (HP:0002418)2.14292986
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.14208088
79Cellular immunodeficiency (HP:0005374)2.14054978
80Pallor (HP:0000980)2.13024253
81Severe combined immunodeficiency (HP:0004430)2.12857886
82Atrophy/Degeneration involving motor neurons (HP:0007373)2.12363527
83Abnormality of glycolysis (HP:0004366)2.10998724
84Pancreatic fibrosis (HP:0100732)2.10556163
85Embryonal renal neoplasm (HP:0011794)2.06734224
86Renal Fanconi syndrome (HP:0001994)2.06516853
87Tracheoesophageal fistula (HP:0002575)2.04755499
88Respiratory failure (HP:0002878)2.03576810
89Hyperalaninemia (HP:0003348)2.02320492
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02320492
91Abnormality of alanine metabolism (HP:0010916)2.02320492
92Renal duplication (HP:0000075)2.02150170
93Thrombocytosis (HP:0001894)2.01324234
94Rough bone trabeculation (HP:0100670)2.00602370
95Absent epiphyses (HP:0010577)2.00344495
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.00344495
97Sloping forehead (HP:0000340)1.99732978
98Exercise intolerance (HP:0003546)1.98686821
99Lymphoma (HP:0002665)1.97735888
100Cortical dysplasia (HP:0002539)1.95114708
101Ependymoma (HP:0002888)1.94977880
102Volvulus (HP:0002580)1.92416153
103Abnormality of the carotid arteries (HP:0005344)1.92410061
104Medial flaring of the eyebrow (HP:0010747)1.88628191
105Absent thumb (HP:0009777)1.86105293
106Abnormal protein glycosylation (HP:0012346)1.85695005
107Abnormal glycosylation (HP:0012345)1.85695005
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85695005
109Abnormal protein N-linked glycosylation (HP:0012347)1.85695005
110Abnormal sex determination (HP:0012244)1.85624512
111Sex reversal (HP:0012245)1.85624512
112Optic disc pallor (HP:0000543)1.85432371
113Neoplasm of the adrenal gland (HP:0100631)1.85431425
114Increased muscle lipid content (HP:0009058)1.84950383
115Macrocytic anemia (HP:0001972)1.84546907
116Pancytopenia (HP:0001876)1.84305434
117Anencephaly (HP:0002323)1.84056671
118Slender long bone (HP:0003100)1.82811698
119Broad distal phalanx of finger (HP:0009836)1.81970112
120Leukodystrophy (HP:0002415)1.81200120
121Dicarboxylic aciduria (HP:0003215)1.80649545
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80649545
123Progressive microcephaly (HP:0000253)1.80539923
124Methylmalonic acidemia (HP:0002912)1.80526796
125Abnormality of DNA repair (HP:0003254)1.79500558
126Retinal dysplasia (HP:0007973)1.79145775
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78890728
128Hypoplastic pelvis (HP:0008839)1.78233927
129Preaxial hand polydactyly (HP:0001177)1.78199928
130Short thumb (HP:0009778)1.78146204
131Aplasia/Hypoplasia of the thymus (HP:0010515)1.77033183
132Multiple enchondromatosis (HP:0005701)1.76058839
133Horseshoe kidney (HP:0000085)1.75190359
134Congenital primary aphakia (HP:0007707)1.75181049
135Absent radius (HP:0003974)1.74152466
136High anterior hairline (HP:0009890)1.73780825
137Abnormality of B cell number (HP:0010975)1.72537551
138B lymphocytopenia (HP:0010976)1.72537551
139Lissencephaly (HP:0001339)1.72432105
140Carpal bone hypoplasia (HP:0001498)1.71028119
141High pitched voice (HP:0001620)1.70533379
142Short 5th finger (HP:0009237)1.70348991
143Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69092186
144Prominent metopic ridge (HP:0005487)1.68507354
145Poor head control (HP:0002421)1.67536777
146Aplasia involving forearm bones (HP:0009822)1.64791234
147Absent forearm bone (HP:0003953)1.64791234
148Abnormality of chromosome segregation (HP:0002916)1.64517123
149Cleft eyelid (HP:0000625)1.63539259
150Acute lymphatic leukemia (HP:0006721)1.63174823
151Proximal placement of thumb (HP:0009623)1.61093448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.80133682
2VRK24.38393412
3CDC74.24220219
4WEE14.08069886
5CCNB13.93106732
6BRSK13.38433112
7EIF2AK13.01689412
8ACVR1B2.68676597
9STK162.51649848
10VRK12.41684367
11BRSK22.40478103
12ZAK2.27818559
13SIK32.24536098
14SRPK12.15429370
15TESK22.14400670
16DYRK32.10055982
17NEK22.07611148
18PASK2.02351480
19UHMK12.00494284
20TRIM281.95354410
21NUAK11.93171594
22MKNK11.81470174
23ATR1.70260889
24CDK71.63992947
25PLK11.61420267
26KSR11.57118708
27MELK1.52183177
28MAP4K21.51688241
29CSNK1G31.50760512
30PBK1.45290893
31EIF2AK31.43509806
32TGFBR11.43260508
33NEK11.41732921
34* AURKB1.39142453
35RPS6KA41.36611926
36AURKA1.33168004
37PLK41.33033329
38TESK11.32848937
39YES11.26537029
40TTK1.24940745
41BCR1.23222318
42CDK81.21805782
43LIMK11.20925684
44EPHB21.20575118
45PLK31.20380539
46CSNK1A1L1.19838110
47PAK41.16070918
48CSNK1G11.15155143
49CDK191.12552047
50CSNK1G21.10762328
51TAF11.09776654
52MAP3K101.04921779
53ERBB31.04309460
54WNK31.03123792
55DYRK20.97089443
56TLK10.92811465
57CHEK20.91943583
58BTK0.90103746
59MAPK110.88265169
60STK100.88130578
61MAP3K80.87537270
62CLK10.85476534
63IRAK40.83825628
64CDK40.80292021
65CHEK10.79590663
66MAP4K10.78512922
67TSSK60.78477823
68EIF2AK20.77265445
69NME10.76651697
70NME20.75454199
71BLK0.74725538
72PLK20.74600291
73MAPK130.70697906
74STK40.68784759
75DYRK1B0.68019126
76MST40.65702515
77MINK10.63100713
78ERBB20.61933356
79KDR0.61349599
80AKT20.59103507
81DAPK10.57444163
82KIT0.53169293
83BRD40.51692262
84TAOK20.51228037
85MAP2K70.50385607
86CSNK2A10.49858853
87CDK10.49396282
88RPS6KB20.48704269
89CDK20.47172203
90TEC0.46311339
91BMPR1B0.44634956
92LRRK20.44112216
93MKNK20.44013307
94ILK0.43544477
95PAK10.42858704
96MAPKAPK50.42429724
97ATM0.40911119
98MAPKAPK20.40792875
99CDK180.39100798
100CSF1R0.38295367
101LYN0.37646556
102STK390.35828616
103CDK90.34280459
104RPS6KA10.32984657
105BRAF0.32207986
106CDK11A0.32060025
107RPS6KA50.31917747
108PDK20.31048950
109SCYL20.29925622
110CSNK2A20.29644292
111BCKDK0.28366561
112CDK140.28214546
113SMG10.27650866
114PIM10.27067822
115CDK150.27034901
116PRKCI0.25699357
117CDK30.25523474
118ZAP700.25061420
119CDK60.25002927
120TRIB30.24855919
121PRKDC0.24271679
122MARK30.23907682
123MAP3K120.23866885
124CSNK1A10.21832166
125FLT30.21733184
126WNK40.19810924
127MAPKAPK30.19293394
128SYK0.18590122
129PIM20.18587362
130PNCK0.16909534
131CSNK1E0.15384049
132MAP3K40.13881018

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.69690457
2Mismatch repair_Homo sapiens_hsa034304.96493697
3Base excision repair_Homo sapiens_hsa034104.12052755
4Homologous recombination_Homo sapiens_hsa034403.70660442
5Spliceosome_Homo sapiens_hsa030403.69284312
6Cell cycle_Homo sapiens_hsa041103.46604607
7Nucleotide excision repair_Homo sapiens_hsa034202.96185966
8Proteasome_Homo sapiens_hsa030502.96103009
9Ribosome_Homo sapiens_hsa030102.73383792
10Pyrimidine metabolism_Homo sapiens_hsa002402.59513131
11Fanconi anemia pathway_Homo sapiens_hsa034602.31102951
12RNA transport_Homo sapiens_hsa030132.28762210
13RNA polymerase_Homo sapiens_hsa030202.22395439
14Non-homologous end-joining_Homo sapiens_hsa034502.04072903
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90863394
16One carbon pool by folate_Homo sapiens_hsa006701.67674091
17RNA degradation_Homo sapiens_hsa030181.67479713
18p53 signaling pathway_Homo sapiens_hsa041151.62182852
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50261036
20mRNA surveillance pathway_Homo sapiens_hsa030151.43471110
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41649465
22Fatty acid elongation_Homo sapiens_hsa000621.41265569
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40781275
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35066717
25Notch signaling pathway_Homo sapiens_hsa043301.31919163
26Basal transcription factors_Homo sapiens_hsa030221.31917131
27Purine metabolism_Homo sapiens_hsa002301.31001006
28Systemic lupus erythematosus_Homo sapiens_hsa053221.27952267
29Propanoate metabolism_Homo sapiens_hsa006401.25325235
30Protein export_Homo sapiens_hsa030601.19733413
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13380258
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12920892
33Oocyte meiosis_Homo sapiens_hsa041141.08723396
34Epstein-Barr virus infection_Homo sapiens_hsa051691.06157060
35Pyruvate metabolism_Homo sapiens_hsa006201.04083851
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02285295
37Herpes simplex infection_Homo sapiens_hsa051681.00034413
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98412890
39N-Glycan biosynthesis_Homo sapiens_hsa005100.92369759
40HTLV-I infection_Homo sapiens_hsa051660.91842098
41Steroid biosynthesis_Homo sapiens_hsa001000.90943322
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89098763
43Viral carcinogenesis_Homo sapiens_hsa052030.84106964
44Butanoate metabolism_Homo sapiens_hsa006500.82306368
45Basal cell carcinoma_Homo sapiens_hsa052170.81162740
46Parkinsons disease_Homo sapiens_hsa050120.76818968
47Peroxisome_Homo sapiens_hsa041460.71145871
48Legionellosis_Homo sapiens_hsa051340.66151168
49MicroRNAs in cancer_Homo sapiens_hsa052060.65432837
50Alcoholism_Homo sapiens_hsa050340.65172652
51Folate biosynthesis_Homo sapiens_hsa007900.64233432
52Primary immunodeficiency_Homo sapiens_hsa053400.63963582
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63093084
54Shigellosis_Homo sapiens_hsa051310.60944137
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59621437
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59458191
57Hepatitis B_Homo sapiens_hsa051610.58052724
58Huntingtons disease_Homo sapiens_hsa050160.57911928
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54859277
60Fatty acid metabolism_Homo sapiens_hsa012120.53966302
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53458249
62Small cell lung cancer_Homo sapiens_hsa052220.51725795
63Cardiac muscle contraction_Homo sapiens_hsa042600.51530549
64Measles_Homo sapiens_hsa051620.51521019
65Hedgehog signaling pathway_Homo sapiens_hsa043400.51141328
66Pentose phosphate pathway_Homo sapiens_hsa000300.50913653
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.50673319
68Glutathione metabolism_Homo sapiens_hsa004800.48956399
69Oxidative phosphorylation_Homo sapiens_hsa001900.48906078
70Colorectal cancer_Homo sapiens_hsa052100.48556903
71Hippo signaling pathway_Homo sapiens_hsa043900.45683716
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45557799
73Leishmaniasis_Homo sapiens_hsa051400.40656518
74Antigen processing and presentation_Homo sapiens_hsa046120.39905730
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38582327
76Chronic myeloid leukemia_Homo sapiens_hsa052200.37867214
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37666588
78Selenocompound metabolism_Homo sapiens_hsa004500.37360681
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36539782
80Apoptosis_Homo sapiens_hsa042100.36187737
81Bladder cancer_Homo sapiens_hsa052190.32667387
82Pancreatic cancer_Homo sapiens_hsa052120.32134949
83Biosynthesis of amino acids_Homo sapiens_hsa012300.29804008
84Thyroid cancer_Homo sapiens_hsa052160.29271817
85Tryptophan metabolism_Homo sapiens_hsa003800.29103450
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27057810
87Fatty acid degradation_Homo sapiens_hsa000710.26141878
88Wnt signaling pathway_Homo sapiens_hsa043100.25771457
89Pathways in cancer_Homo sapiens_hsa052000.25462117
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25429542
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25259244
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24691835
93Viral myocarditis_Homo sapiens_hsa054160.24574737
94Caffeine metabolism_Homo sapiens_hsa002320.24151124
95Non-small cell lung cancer_Homo sapiens_hsa052230.23863530
96Regulation of autophagy_Homo sapiens_hsa041400.23415823
97Vitamin B6 metabolism_Homo sapiens_hsa007500.22677561
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22285061
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.22037259
100Influenza A_Homo sapiens_hsa051640.21958296
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20580810
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.19680117
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.19658009
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19425750
105Carbon metabolism_Homo sapiens_hsa012000.18656464
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17511214
107beta-Alanine metabolism_Homo sapiens_hsa004100.17199998
108Sulfur relay system_Homo sapiens_hsa041220.16168068
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15976386
110TGF-beta signaling pathway_Homo sapiens_hsa043500.15700967
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.15295008
112Alzheimers disease_Homo sapiens_hsa050100.14849055
113Arginine and proline metabolism_Homo sapiens_hsa003300.14711993
114Tyrosine metabolism_Homo sapiens_hsa003500.14635531
115Asthma_Homo sapiens_hsa053100.14301158
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14282811
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14120196
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13452341
119Nitrogen metabolism_Homo sapiens_hsa009100.12578601
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12205223
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12127603
122Hematopoietic cell lineage_Homo sapiens_hsa046400.12034165
123Metabolic pathways_Homo sapiens_hsa011000.11524998
124Lysine degradation_Homo sapiens_hsa003100.10061918
125B cell receptor signaling pathway_Homo sapiens_hsa046620.09855169
126Pertussis_Homo sapiens_hsa051330.09181019
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08581900
128Phototransduction_Homo sapiens_hsa047440.07323599
129Olfactory transduction_Homo sapiens_hsa047400.03726501
130Collecting duct acid secretion_Homo sapiens_hsa049660.03233781
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.01803383
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.01299801
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00743414
134Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0047653

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