HMGN2P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.49925332
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.95506247
3ATP synthesis coupled proton transport (GO:0015986)5.46217757
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.46217757
5Arp2/3 complex-mediated actin nucleation (GO:0034314)5.37905112
6cullin deneddylation (GO:0010388)5.12928322
7DNA deamination (GO:0045006)4.96972916
8sequestering of actin monomers (GO:0042989)4.90140450
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.81461867
10actin nucleation (GO:0045010)4.77451345
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.72664265
12protein deneddylation (GO:0000338)4.56988873
13protein neddylation (GO:0045116)4.47026816
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.45080248
15regulation of cellular amino acid metabolic process (GO:0006521)4.42598840
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.41451235
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37784319
18intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.33409727
19signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.33409727
20signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.33307733
21signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.33307733
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.33307733
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.30834752
24cytidine metabolic process (GO:0046087)4.17268551
25cytidine catabolic process (GO:0006216)4.17268551
26cytidine deamination (GO:0009972)4.17268551
27piRNA metabolic process (GO:0034587)4.15041358
28signal transduction involved in DNA integrity checkpoint (GO:0072401)4.14154685
29signal transduction involved in DNA damage checkpoint (GO:0072422)4.14154685
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.12674143
31DNA double-strand break processing (GO:0000729)4.10603315
32signal transduction involved in cell cycle checkpoint (GO:0072395)4.08792949
33fucose catabolic process (GO:0019317)3.99501075
34L-fucose metabolic process (GO:0042354)3.99501075
35L-fucose catabolic process (GO:0042355)3.99501075
36rRNA modification (GO:0000154)3.97993670
37negative regulation of ligase activity (GO:0051352)3.95372068
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.95372068
39DNA catabolic process, exonucleolytic (GO:0000738)3.94506749
40mismatch repair (GO:0006298)3.92564410
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.88558838
42respiratory electron transport chain (GO:0022904)3.84557698
43electron transport chain (GO:0022900)3.80973701
44DNA ligation (GO:0006266)3.79105101
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.69613036
46rRNA methylation (GO:0031167)3.67903665
47proteasome assembly (GO:0043248)3.64966781
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.62521696
49resolution of meiotic recombination intermediates (GO:0000712)3.58993653
50pyrimidine ribonucleoside catabolic process (GO:0046133)3.55844984
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50414340
52ribosomal small subunit assembly (GO:0000028)3.48568780
53activated T cell proliferation (GO:0050798)3.45260570
54positive regulation of ligase activity (GO:0051351)3.44497074
55male meiosis I (GO:0007141)3.44086802
56chromosome organization involved in meiosis (GO:0070192)3.42874082
57response to pheromone (GO:0019236)3.41566922
58male meiosis (GO:0007140)3.40967404
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.34783986
60DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.34284120
61regulation of RIG-I signaling pathway (GO:0039535)3.33033729
62regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.31178301
63behavioral response to nicotine (GO:0035095)3.30651336
64DNA methylation involved in gamete generation (GO:0043046)3.30376570
65meiosis I (GO:0007127)3.30034692
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29954281
67establishment of integrated proviral latency (GO:0075713)3.27128879
68pseudouridine synthesis (GO:0001522)3.25932669
69positive regulation of cell cycle arrest (GO:0071158)3.23160125
70negative regulation by host of viral transcription (GO:0043922)3.22064516
71regulation of ubiquitin-protein transferase activity (GO:0051438)3.09833199
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.08667486
73regulation of cellular amine metabolic process (GO:0033238)3.06643520
74protein-cofactor linkage (GO:0018065)3.06106361
75negative regulation of cell cycle G1/S phase transition (GO:1902807)3.04343178
76negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.04343178
77ATP biosynthetic process (GO:0006754)3.00896883
78mannosylation (GO:0097502)2.98040078
79inner mitochondrial membrane organization (GO:0007007)2.95640062
80ribonucleoprotein complex disassembly (GO:0032988)2.91897796
81regulation of ligase activity (GO:0051340)2.91266345
82cellular response to interferon-beta (GO:0035458)2.90960619
83protein complex biogenesis (GO:0070271)2.90563600
84negative T cell selection (GO:0043383)2.90193879
85aldehyde catabolic process (GO:0046185)2.86281012
86regulation of double-strand break repair via homologous recombination (GO:0010569)2.84249408
87CENP-A containing nucleosome assembly (GO:0034080)2.83839805
88cytolysis (GO:0019835)2.82172931
89signal transduction in response to DNA damage (GO:0042770)2.81217793
90regulation of DNA endoreduplication (GO:0032875)2.80923954
91chaperone-mediated protein transport (GO:0072321)2.80640013
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.79411068
93mitochondrial respiratory chain complex assembly (GO:0033108)2.78456213
94hydrogen ion transmembrane transport (GO:1902600)2.75919643
95reciprocal DNA recombination (GO:0035825)2.71268998
96reciprocal meiotic recombination (GO:0007131)2.71268998
97regulation of cell cycle arrest (GO:0071156)2.70277505
98chromatin remodeling at centromere (GO:0031055)2.69573849
99intracellular protein transmembrane import (GO:0044743)2.68771063
100replication fork processing (GO:0031297)2.66846743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78975302
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.54616700
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.26969621
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.93875468
5IGF1R_20145208_ChIP-Seq_DFB_Human3.17484174
6VDR_22108803_ChIP-Seq_LS180_Human3.10132496
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02792374
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89300094
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83475181
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77448600
11ELK1_19687146_ChIP-ChIP_HELA_Human2.68492771
12VDR_23849224_ChIP-Seq_CD4+_Human2.55850184
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54032917
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.38246602
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30482363
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27215065
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17184050
18FOXP3_21729870_ChIP-Seq_TREG_Human2.14458760
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12163210
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00203252
21ZNF274_21170338_ChIP-Seq_K562_Hela1.97530740
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93832316
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93255339
24E2F7_22180533_ChIP-Seq_HELA_Human1.89241400
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83687375
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.76759196
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.76093723
28EWS_26573619_Chip-Seq_HEK293_Human1.73538799
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.66980849
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.66900127
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.58617807
32MYC_18940864_ChIP-ChIP_HL60_Human1.56812423
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53058449
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42732496
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41928891
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41142452
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.40560643
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37450757
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36191916
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30644146
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30469366
42NCOR_22424771_ChIP-Seq_293T_Human1.30331912
43FUS_26573619_Chip-Seq_HEK293_Human1.30290992
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.30240902
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30240902
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28138833
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27861084
48ER_23166858_ChIP-Seq_MCF-7_Human1.27640710
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27409452
50TP53_22573176_ChIP-Seq_HFKS_Human1.26156722
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25575790
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23153759
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22683542
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22196524
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21432874
56TTF2_22483619_ChIP-Seq_HELA_Human1.21382398
57CIITA_25753668_ChIP-Seq_RAJI_Human1.17618664
58XRN2_22483619_ChIP-Seq_HELA_Human1.17498163
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17422423
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17387340
61DCP1A_22483619_ChIP-Seq_HELA_Human1.16298253
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14081177
63GABP_19822575_ChIP-Seq_HepG2_Human1.12502685
64AR_20517297_ChIP-Seq_VCAP_Human1.11934503
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11061922
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11013845
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09201079
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08929022
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08054757
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05413067
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04250443
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03669686
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03092399
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02870783
75NANOG_19829295_ChIP-Seq_ESCs_Human1.02385094
76SOX2_19829295_ChIP-Seq_ESCs_Human1.02385094
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01928716
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01369534
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.00588096
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98174151
81P300_19829295_ChIP-Seq_ESCs_Human0.97745582
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97678537
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.96923134
84GATA3_26560356_Chip-Seq_TH2_Human0.96703433
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.95975445
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95947463
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95632088
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.95062881
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95049828
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94252297
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94125625
92IRF8_21731497_ChIP-ChIP_J774_Mouse0.93386875
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92697742
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91148580
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90167850
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89958234
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.89847395
98HOXB7_26014856_ChIP-Seq_BT474_Human0.89089396
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88861850
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88731106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.44896581
2MP0008877_abnormal_DNA_methylation3.05766962
3MP0005671_abnormal_response_to2.58627907
4MP0003786_premature_aging2.45793825
5MP0002166_altered_tumor_susceptibility2.45746579
6MP0002736_abnormal_nociception_after2.43269541
7MP0006072_abnormal_retinal_apoptosis2.40869048
8MP0002102_abnormal_ear_morphology2.29832377
9MP0001968_abnormal_touch/_nociception2.28604202
10MP0008995_early_reproductive_senescence2.26068853
11MP0004147_increased_porphyrin_level2.25176644
12MP0005084_abnormal_gallbladder_morpholo2.17179600
13MP0003646_muscle_fatigue2.14320622
14MP0003806_abnormal_nucleotide_metabolis2.12555368
15MP0008007_abnormal_cellular_replicative2.10988891
16MP0002822_catalepsy2.10336241
17MP0002837_dystrophic_cardiac_calcinosis2.08142487
18MP0002006_tumorigenesis2.03971591
19MP0008058_abnormal_DNA_repair2.00667106
20MP0006036_abnormal_mitochondrial_physio1.76329928
21MP0010094_abnormal_chromosome_stability1.66506591
22MP0001529_abnormal_vocalization1.64909991
23MP0002938_white_spotting1.63755399
24MP0002163_abnormal_gland_morphology1.63141865
25MP0005075_abnormal_melanosome_morpholog1.56501275
26MP0005551_abnormal_eye_electrophysiolog1.55368450
27MP0009333_abnormal_splenocyte_physiolog1.54978741
28MP0002160_abnormal_reproductive_system1.52517995
29MP0005379_endocrine/exocrine_gland_phen1.50663640
30MP0005389_reproductive_system_phenotype1.49395010
31MP0002876_abnormal_thyroid_physiology1.47430055
32MP0010386_abnormal_urinary_bladder1.46766195
33MP0002210_abnormal_sex_determination1.42854341
34MP0001835_abnormal_antigen_presentation1.42807371
35MP0004381_abnormal_hair_follicle1.41999578
36MP0001346_abnormal_lacrimal_gland1.40856823
37MP0006292_abnormal_olfactory_placode1.38665096
38MP0003718_maternal_effect1.36768635
39MP0002009_preneoplasia1.36377947
40MP0002095_abnormal_skin_pigmentation1.32704961
41MP0001485_abnormal_pinna_reflex1.25756898
42MP0000372_irregular_coat_pigmentation1.23647919
43MP0004957_abnormal_blastocyst_morpholog1.22380706
44MP0000685_abnormal_immune_system1.22369286
45MP0005645_abnormal_hypothalamus_physiol1.22325171
46MP0008872_abnormal_physiological_respon1.22172772
47MP0001764_abnormal_homeostasis1.21155277
48MP0005253_abnormal_eye_physiology1.19884576
49MP0006035_abnormal_mitochondrial_morpho1.15613793
50MP0001929_abnormal_gametogenesis1.15436418
51MP0002638_abnormal_pupillary_reflex1.13372079
52MP0004145_abnormal_muscle_electrophysio1.13336806
53MP0001145_abnormal_male_reproductive1.13214098
54MP0000653_abnormal_sex_gland1.13200713
55MP0006082_CNS_inflammation1.11842096
56MP0001905_abnormal_dopamine_level1.11592326
57MP0003252_abnormal_bile_duct1.10981178
58MP0005646_abnormal_pituitary_gland1.08796615
59MP0001119_abnormal_female_reproductive1.06949810
60MP0000631_abnormal_neuroendocrine_gland1.06277958
61MP0003880_abnormal_central_pattern1.06141909
62MP0002138_abnormal_hepatobiliary_system1.05858836
63MP0004885_abnormal_endolymph1.04483840
64MP0002928_abnormal_bile_duct1.03411962
65MP0004142_abnormal_muscle_tone1.02022260
66MP0001919_abnormal_reproductive_system1.01080749
67MP0004215_abnormal_myocardial_fiber1.00293123
68MP0004043_abnormal_pH_regulation0.99605913
69MP0005167_abnormal_blood-brain_barrier0.99043925
70MP0002282_abnormal_trachea_morphology0.98858128
71MP0003698_abnormal_male_reproductive0.95327586
72MP0008932_abnormal_embryonic_tissue0.94859992
73MP0003763_abnormal_thymus_physiology0.94624828
74MP0003195_calcinosis0.94294377
75MP0004036_abnormal_muscle_relaxation0.93732864
76MP0003693_abnormal_embryo_hatching0.92869673
77MP0001800_abnormal_humoral_immune0.92558317
78MP0005503_abnormal_tendon_morphology0.87666731
79MP0002751_abnormal_autonomic_nervous0.86131683
80MP0002653_abnormal_ependyma_morphology0.85541414
81MP0005377_hearing/vestibular/ear_phenot0.82789815
82MP0003878_abnormal_ear_physiology0.82789815
83MP0001293_anophthalmia0.82344271
84MP0002272_abnormal_nervous_system0.80682006
85MP0002723_abnormal_immune_serum0.77092694
86MP0009745_abnormal_behavioral_response0.76287513
87MP0001661_extended_life_span0.73862167
88MP0009697_abnormal_copulation0.73425028
89MP0008789_abnormal_olfactory_epithelium0.73032102
90MP0005670_abnormal_white_adipose0.72381042
91MP0002420_abnormal_adaptive_immunity0.71912170
92MP0005647_abnormal_sex_gland0.71894144
93MP0006276_abnormal_autonomic_nervous0.68447561
94MP0001819_abnormal_immune_cell0.66688733
95MP0001963_abnormal_hearing_physiology0.65140633
96MP0009046_muscle_twitch0.64881891
97MP0005000_abnormal_immune_tolerance0.64359795
98MP0009379_abnormal_foot_pigmentation0.63676421
99MP0005195_abnormal_posterior_eye0.63372024
100MP0001984_abnormal_olfaction0.62751422

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.66681130
2Mitochondrial inheritance (HP:0001427)4.00117418
3Increased hepatocellular lipid droplets (HP:0006565)3.93690515
4Lipid accumulation in hepatocytes (HP:0006561)3.71823397
5Acute necrotizing encephalopathy (HP:0006965)3.70944600
6Increased CSF lactate (HP:0002490)3.67265647
7Hepatocellular necrosis (HP:0001404)3.54286643
8Renal Fanconi syndrome (HP:0001994)3.53928306
9Acute encephalopathy (HP:0006846)3.52451257
10Abnormal mitochondria in muscle tissue (HP:0008316)3.45338731
11Congenital, generalized hypertrichosis (HP:0004540)3.41151344
12Autoimmune thrombocytopenia (HP:0001973)3.38902354
13Hepatic necrosis (HP:0002605)3.36491066
14Congenital stationary night blindness (HP:0007642)3.18421247
15Elevated erythrocyte sedimentation rate (HP:0003565)3.16533936
16Progressive macrocephaly (HP:0004481)3.10936885
17Increased IgM level (HP:0003496)3.06563764
18Autoimmune hemolytic anemia (HP:0001890)3.06470741
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.03209539
20Pancreatic cysts (HP:0001737)2.93760038
21Increased intramyocellular lipid droplets (HP:0012240)2.90902410
22Severe combined immunodeficiency (HP:0004430)2.89652093
23Abnormal number of erythroid precursors (HP:0012131)2.89456531
24Supernumerary spleens (HP:0009799)2.84572997
25Amyotrophic lateral sclerosis (HP:0007354)2.80927897
26Oligodactyly (hands) (HP:0001180)2.74760637
27Cerebral edema (HP:0002181)2.74041019
28Abnormality of the labia minora (HP:0012880)2.69949840
29Absent thumb (HP:0009777)2.59219735
30Abnormality of cells of the erythroid lineage (HP:0012130)2.58931664
31Atrophy/Degeneration involving motor neurons (HP:0007373)2.52726347
32Pancreatic fibrosis (HP:0100732)2.52172773
33Meckel diverticulum (HP:0002245)2.50276956
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.49541619
353-Methylglutaconic aciduria (HP:0003535)2.47421729
36True hermaphroditism (HP:0010459)2.46753795
37Increased muscle lipid content (HP:0009058)2.46016695
38Clubbing of toes (HP:0100760)2.45707982
39Exertional dyspnea (HP:0002875)2.43088291
40Combined immunodeficiency (HP:0005387)2.36453391
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35574687
42Abnormality of the ileum (HP:0001549)2.33823857
43Abnormality of eosinophils (HP:0001879)2.33650270
44Increased serum lactate (HP:0002151)2.31698453
45Eosinophilia (HP:0001880)2.31612936
46Thyroiditis (HP:0100646)2.29139994
47Pancytopenia (HP:0001876)2.28818613
48Hyperglycinuria (HP:0003108)2.28443711
49Abnormality of chromosome stability (HP:0003220)2.28359150
50Abnormality of T cells (HP:0002843)2.27272221
51Abnormality of T cell number (HP:0011839)2.25683867
52Abnormality of renal resorption (HP:0011038)2.24676296
53Abolished electroretinogram (ERG) (HP:0000550)2.23565136
54Optic disc pallor (HP:0000543)2.23001818
55Generalized aminoaciduria (HP:0002909)2.21942789
56Nephronophthisis (HP:0000090)2.21209593
57Pendular nystagmus (HP:0012043)2.20826977
58Abnormal lung lobation (HP:0002101)2.17265504
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16100820
60Panhypogammaglobulinemia (HP:0003139)2.14846388
61Hyperglycinemia (HP:0002154)2.14229618
62Lactic acidosis (HP:0003128)2.14048284
63Abnormality of T cell physiology (HP:0011840)2.10863350
64Abnormality of serum amino acid levels (HP:0003112)2.07898739
65IgG deficiency (HP:0004315)2.07189451
66Glycosuria (HP:0003076)2.07147899
67Abnormality of urine glucose concentration (HP:0011016)2.07147899
68Abnormality of alanine metabolism (HP:0010916)2.03903557
69Hyperalaninemia (HP:0003348)2.03903557
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03903557
71Medial flaring of the eyebrow (HP:0010747)2.03588347
72Delayed CNS myelination (HP:0002188)2.01851456
73Respiratory difficulties (HP:0002880)2.01410716
74Respiratory failure (HP:0002878)2.00020302
75Duodenal stenosis (HP:0100867)1.99474174
76Small intestinal stenosis (HP:0012848)1.99474174
77Abnormality of the renal medulla (HP:0100957)1.98790046
78Colon cancer (HP:0003003)1.98277823
79CNS demyelination (HP:0007305)1.98201468
80Abnormality of serine family amino acid metabolism (HP:0010894)1.96357704
81Abnormality of glycine metabolism (HP:0010895)1.96357704
82Hypoglycemic seizures (HP:0002173)1.95623001
83Abnormal rod and cone electroretinograms (HP:0008323)1.94760516
84Abnormality of the preputium (HP:0100587)1.92529097
85Abnormal drinking behavior (HP:0030082)1.92468073
86Polydipsia (HP:0001959)1.92468073
87Cystic liver disease (HP:0006706)1.91206155
88Oral leukoplakia (HP:0002745)1.91056617
89Lethargy (HP:0001254)1.89657667
90Molar tooth sign on MRI (HP:0002419)1.89573945
91Abnormality of midbrain morphology (HP:0002418)1.89573945
92Encephalitis (HP:0002383)1.82437338
93Decreased central vision (HP:0007663)1.82042641
94Limb hypertonia (HP:0002509)1.80977647
95Reticulocytopenia (HP:0001896)1.79974029
96Oligodactyly (HP:0012165)1.79900535
97Gonadotropin excess (HP:0000837)1.79425920
98Abnormality of the renal cortex (HP:0011035)1.76652064
99Chromsome breakage (HP:0040012)1.76386855
100Abnormality of the duodenum (HP:0002246)1.76223676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.78646048
2STK163.53166023
3VRK23.40305142
4EIF2AK33.32664514
5MAP3K122.97548006
6KDR2.96576868
7EPHA32.44720975
8EIF2AK12.43763045
9SRPK12.30391752
10BCR2.20902099
11TESK22.15605188
12ZAK1.94959865
13NUAK11.93646439
14OXSR11.92781973
15VRK11.86709034
16ADRBK21.82511151
17TXK1.79409921
18DYRK21.79091002
19TSSK61.75349335
20BRSK21.71214183
21TLK11.66448455
22PASK1.55525319
23MKNK11.47362984
24BRSK11.43136319
25GRK11.39314898
26MAP4K21.38305354
27EPHB11.35686888
28TAOK31.31517662
29TNIK1.30120472
30STK391.29594676
31BCKDK1.26074337
32CSNK1G31.26015017
33PLK31.25664513
34MKNK21.22426547
35NEK11.22058776
36ACVR1B1.15239293
37MST41.15028659
38EIF2AK21.13394745
39RPS6KA51.03067314
40PLK21.02810201
41WNK30.98348724
42CSNK1G20.97471851
43FRK0.97425945
44CSNK1A1L0.96792137
45CDC70.96023703
46DAPK10.95087734
47TGFBR20.94837266
48WNK40.90095924
49MAPK150.87153824
50PAK40.85301479
51MAP4K10.84560700
52CSNK1G10.83645360
53FGFR20.80787670
54STK38L0.80155573
55NLK0.79186092
56NME10.78564741
57PINK10.76910667
58LIMK10.74927430
59PDK20.74559125
60MAP3K110.73854940
61RPS6KA40.71102792
62DAPK20.68553778
63MAPKAPK50.66756744
64MARK30.62626701
65EPHA40.62297222
66WEE10.61446110
67PNCK0.58812225
68GRK50.56327718
69AURKB0.55271401
70ITK0.53386895
71ATR0.53198205
72PRKCQ0.52487951
73INSRR0.51166237
74CDK190.50464669
75MAP3K50.50344074
76DYRK30.50097685
77PLK10.48493200
78MAPKAPK30.45661328
79FES0.43545835
80CSNK2A10.42289722
81PRKCI0.42134833
82PRKCG0.41874476
83GRK70.41468421
84TRIM280.40141114
85BTK0.39196516
86GRK60.39099404
87CSNK2A20.39073060
88IKBKB0.38377776
89SYK0.36699583
90MINK10.35964573
91PKN10.35779354
92LYN0.34446124
93MAPKAPK20.32614768
94AURKA0.30398132
95KIT0.30044602
96TEC0.29126792
97DYRK1B0.28299354
98ATM0.28254636
99IRAK40.27562061
100PRKCE0.26875252

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.99740581
2Oxidative phosphorylation_Homo sapiens_hsa001903.90945614
3Parkinsons disease_Homo sapiens_hsa050123.45240841
4Protein export_Homo sapiens_hsa030602.89834037
5Ribosome_Homo sapiens_hsa030102.88386026
6Mismatch repair_Homo sapiens_hsa034302.73266956
7DNA replication_Homo sapiens_hsa030302.45641812
8Phototransduction_Homo sapiens_hsa047442.39192580
9Huntingtons disease_Homo sapiens_hsa050162.34078651
10Alzheimers disease_Homo sapiens_hsa050102.27191691
11Primary immunodeficiency_Homo sapiens_hsa053402.20180508
12Homologous recombination_Homo sapiens_hsa034402.02823706
13Non-homologous end-joining_Homo sapiens_hsa034501.99837888
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95402012
15RNA polymerase_Homo sapiens_hsa030201.91347501
16Propanoate metabolism_Homo sapiens_hsa006401.90214933
17Antigen processing and presentation_Homo sapiens_hsa046121.88959517
18Fanconi anemia pathway_Homo sapiens_hsa034601.77256422
19Spliceosome_Homo sapiens_hsa030401.67595352
20RNA degradation_Homo sapiens_hsa030181.63843129
21RNA transport_Homo sapiens_hsa030131.49412214
22One carbon pool by folate_Homo sapiens_hsa006701.47368032
23Autoimmune thyroid disease_Homo sapiens_hsa053201.46063217
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44281806
25Allograft rejection_Homo sapiens_hsa053301.43185618
26Cardiac muscle contraction_Homo sapiens_hsa042601.42043616
27Graft-versus-host disease_Homo sapiens_hsa053321.41996868
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40317708
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36723475
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31907067
31Type I diabetes mellitus_Homo sapiens_hsa049401.28355595
32Nucleotide excision repair_Homo sapiens_hsa034201.26643083
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23980593
34Basal transcription factors_Homo sapiens_hsa030221.23855252
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17262637
36Fatty acid elongation_Homo sapiens_hsa000621.15619934
37Asthma_Homo sapiens_hsa053101.14193641
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02314887
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.01631192
40Pyrimidine metabolism_Homo sapiens_hsa002401.00669705
41Pyruvate metabolism_Homo sapiens_hsa006200.97378805
42Purine metabolism_Homo sapiens_hsa002300.91734622
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90390166
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90341752
45Butanoate metabolism_Homo sapiens_hsa006500.89444399
46Tryptophan metabolism_Homo sapiens_hsa003800.87420503
47Linoleic acid metabolism_Homo sapiens_hsa005910.86994257
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80984518
49Selenocompound metabolism_Homo sapiens_hsa004500.78210729
50Peroxisome_Homo sapiens_hsa041460.76631708
51Collecting duct acid secretion_Homo sapiens_hsa049660.73156095
52Base excision repair_Homo sapiens_hsa034100.71261358
53Hematopoietic cell lineage_Homo sapiens_hsa046400.71091703
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69054456
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68928935
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66232764
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64874445
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.64604068
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60895093
60Systemic lupus erythematosus_Homo sapiens_hsa053220.60841849
61Cell cycle_Homo sapiens_hsa041100.60289693
62Ether lipid metabolism_Homo sapiens_hsa005650.60086676
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59860516
64beta-Alanine metabolism_Homo sapiens_hsa004100.58099811
65Sulfur relay system_Homo sapiens_hsa041220.55164044
66Metabolic pathways_Homo sapiens_hsa011000.54327933
67Fatty acid metabolism_Homo sapiens_hsa012120.54156485
68N-Glycan biosynthesis_Homo sapiens_hsa005100.53094849
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52746333
70Taste transduction_Homo sapiens_hsa047420.50869520
71Rheumatoid arthritis_Homo sapiens_hsa053230.47981504
72Fatty acid degradation_Homo sapiens_hsa000710.45939320
73Shigellosis_Homo sapiens_hsa051310.45863074
74Nitrogen metabolism_Homo sapiens_hsa009100.45203168
75Regulation of autophagy_Homo sapiens_hsa041400.44620131
76Olfactory transduction_Homo sapiens_hsa047400.41679415
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41534382
78Epstein-Barr virus infection_Homo sapiens_hsa051690.40564642
79Viral myocarditis_Homo sapiens_hsa054160.39649196
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.38093727
81Mineral absorption_Homo sapiens_hsa049780.37438585
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35761189
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35335847
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34875115
85Basal cell carcinoma_Homo sapiens_hsa052170.34172805
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34172778
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.33204436
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.32085352
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31333845
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31090941
91Hedgehog signaling pathway_Homo sapiens_hsa043400.30776724
92Retinol metabolism_Homo sapiens_hsa008300.29322153
93mRNA surveillance pathway_Homo sapiens_hsa030150.27731118
94Sulfur metabolism_Homo sapiens_hsa009200.26776997
95Caffeine metabolism_Homo sapiens_hsa002320.23337869
96Measles_Homo sapiens_hsa051620.22739124
97p53 signaling pathway_Homo sapiens_hsa041150.21363357
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19811668
99Oocyte meiosis_Homo sapiens_hsa041140.19344974
100Arachidonic acid metabolism_Homo sapiens_hsa005900.18436472

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