ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of actin filament depolymerization (GO:0030836)	5.33600063
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.04424232
3	sequestering of actin monomers (GO:0042989)	4.86526446
4	regulation of chemokine-mediated signaling pathway (GO:0070099)	4.65779250
5	purine nucleobase biosynthetic process (GO:0009113)	4.44825267
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.35328104
7	cell fate commitment involved in formation of primary germ layer (GO:0060795)	4.06477334
8	nucleobase biosynthetic process (GO:0046112)	3.96163560
9	DNA double-strand break processing (GO:0000729)	3.92216748
10	positive regulation of vesicle fusion (GO:0031340)	3.85790737
11	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.74781819
12	fatty acid elongation (GO:0030497)	3.73970113
13	negative regulation of cell cycle G2/M phase transition (GO:1902750)	3.69794844
14	protein localization to chromosome, centromeric region (GO:0071459)	3.67516500
15	cellular response to zinc ion (GO:0071294)	3.45873809
16	protein localization to kinetochore (GO:0034501)	3.44499946
17	phenol-containing compound catabolic process (GO:0019336)	3.42742080
18	SMAD protein complex assembly (GO:0007183)	3.40573272
19	multicellular organismal aging (GO:0010259)	3.39115280
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.36700986
21	ATP synthesis coupled proton transport (GO:0015986)	3.36700986
22	lymphangiogenesis (GO:0001946)	3.35853597
23	notochord development (GO:0030903)	3.31898534
24	serotonin metabolic process (GO:0042428)	3.30924649
25	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.29389973
26	response to pheromone (GO:0019236)	3.25830390
27	regulation of glomerular filtration (GO:0003093)	3.24449895
28	ganglion development (GO:0061548)	3.16754475
29	chondrocyte proliferation (GO:0035988)	3.15616964
30	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.15331913
31	AMP metabolic process (GO:0046033)	3.11646133
32	cytidine metabolic process (GO:0046087)	3.09978111
33	cytidine catabolic process (GO:0006216)	3.09978111
34	cytidine deamination (GO:0009972)	3.09978111
35	regulation of protein kinase A signaling (GO:0010738)	3.09938727
36	establishment of integrated proviral latency (GO:0075713)	3.08680162
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.00444278
38	formation of translation preinitiation complex (GO:0001731)	3.00389501
39	DNA strand renaturation (GO:0000733)	2.93343717
40	DNA deamination (GO:0045006)	2.93095935
41	response to vitamin E (GO:0033197)	2.90696202
42	positive regulation of Rho protein signal transduction (GO:0035025)	2.89586290
43	response to insecticide (GO:0017085)	2.88422336
44	positive regulation of fatty acid oxidation (GO:0046321)	2.85458792
45	histone H2B ubiquitination (GO:0033523)	2.79320629
46	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.77191117
47	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.77191117
48	primary amino compound metabolic process (GO:1901160)	2.72435134
49	mitotic sister chromatid segregation (GO:0000070)	2.72081909
50	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.69730268
51	negative regulation of fatty acid transport (GO:2000192)	2.69568488
52	respiratory electron transport chain (GO:0022904)	2.68294686
53	gamma-aminobutyric acid transport (GO:0015812)	2.68205715
54	dopamine biosynthetic process (GO:0042416)	2.66452592
55	indolalkylamine metabolic process (GO:0006586)	2.65989512
56	spliceosomal snRNP assembly (GO:0000387)	2.65786207
57	positive regulation of protein depolymerization (GO:1901881)	2.65512878
58	ribosome assembly (GO:0042255)	2.64209030
59	endothelium development (GO:0003158)	2.63688389
60	electron transport chain (GO:0022900)	2.61989391
61	regulation of hippo signaling (GO:0035330)	2.57968839
62	urogenital system development (GO:0001655)	2.57915145
63	purine deoxyribonucleotide catabolic process (GO:0009155)	2.57077956
64	toxin metabolic process (GO:0009404)	2.56892924
65	positive regulation of interleukin-8 secretion (GO:2000484)	2.54803878
66	DNA catabolic process, exonucleolytic (GO:0000738)	2.54061673
67	vascular smooth muscle contraction (GO:0014829)	2.50999094
68	ribosome biogenesis (GO:0042254)	2.50630952
69	mitotic cytokinesis (GO:0000281)	2.50515537
70	regulation of sarcomere organization (GO:0060297)	2.49965162
71	DNA integration (GO:0015074)	2.49910073
72	positive regulation of cell size (GO:0045793)	2.49706182
73	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.49441149
74	sister chromatid segregation (GO:0000819)	2.48943212
75	adenosine metabolic process (GO:0046085)	2.48582632
76	phasic smooth muscle contraction (GO:0014821)	2.46450200
77	positive regulation of glomerulus development (GO:0090193)	2.45588638
78	proteasome assembly (GO:0043248)	2.45352779
79	cytoskeleton-dependent cytokinesis (GO:0061640)	2.44951357
80	histone H2A acetylation (GO:0043968)	2.43034273
81	pyrimidine dimer repair (GO:0006290)	2.41684905
82	somite rostral/caudal axis specification (GO:0032525)	2.41033456
83	thrombin receptor signaling pathway (GO:0070493)	2.38583923
84	regulation of protein kinase C signaling (GO:0090036)	2.37664551
85	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.37655949
86	alkaloid metabolic process (GO:0009820)	2.37279853
87	negative regulation of thymocyte apoptotic process (GO:0070244)	2.37137710
88	DNA replication-dependent nucleosome organization (GO:0034723)	2.36588927
89	DNA replication-dependent nucleosome assembly (GO:0006335)	2.36588927
90	regulation of chemokine secretion (GO:0090196)	2.36555095
91	regulation of interleukin-8 secretion (GO:2000482)	2.35575792
92	purine nucleotide salvage (GO:0032261)	2.35429254
93	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.35393791
94	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.34439770
95	axon extension involved in axon guidance (GO:0048846)	2.34439770
96	RNA localization (GO:0006403)	2.34208488
97	limb bud formation (GO:0060174)	2.33471265
98	heterochromatin organization (GO:0070828)	2.32504443
99	detection of temperature stimulus (GO:0016048)	2.31429876
100	DNA strand elongation involved in DNA replication (GO:0006271)	2.30049088

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.67911280
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.78033378
3	VDR_22108803_ChIP-Seq_LS180_Human	4.37061936
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45740881
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.13860422
6	AR_21909140_ChIP-Seq_LNCAP_Human	3.09529326
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.84782663
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.83171493
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.59731775
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.59626743
11	FUS_26573619_Chip-Seq_HEK293_Human	2.20303591
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.16974252
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.12672992
14	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.09011138
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08592819
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.06882365
17	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.04661838
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04163685
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.03258443
20	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.00458819
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97785689
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97590526
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93579992
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.91711677
25	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.89733304
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.88707483
27	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.86216890
28	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.79070479
29	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.77452203
30	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.66734941
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.61847669
32	GBX2_23144817_ChIP-Seq_PC3_Human	1.58307654
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.50832621
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49996985
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.44169880
36	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.43824850
37	XRN2_22483619_ChIP-Seq_HELA_Human	1.42747343
38	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.41697999
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.40779229
40	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.40014188
41	EWS_26573619_Chip-Seq_HEK293_Human	1.39545529
42	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.33060881
43	RXR_22108803_ChIP-Seq_LS180_Human	1.31327180
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29240210
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28277848
46	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.28178662
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27414963
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.27307607
49	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.25139152
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.22968760
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.20706316
52	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.18388582
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.14016547
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.11283772
55	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06514397
56	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.04986668
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.04527501
58	SOX9_26525672_Chip-Seq_HEART_Mouse	1.04067552
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03760984
60	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.03566464
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03161339
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01684709
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.01009734
64	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.00960878
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97518642
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96914584
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94920868
68	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94810196
69	CBP_21632823_ChIP-Seq_H3396_Human	0.94740383
70	IGF1R_20145208_ChIP-Seq_DFB_Human	0.94567590
71	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.93871379
72	AR_21572438_ChIP-Seq_LNCaP_Human	0.91088289
73	NFYB_21822215_ChIP-Seq_K562_Human	0.91032221
74	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89375872
75	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88713870
76	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.87340845
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.83651213
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.81358112
79	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.81131172
80	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.80746806
81	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.80252437
82	CJUN_26792858_Chip-Seq_BT549_Human	0.79656923
83	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.79516815
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.79183659
85	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.79101419
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.78714512
87	NANOG_19829295_ChIP-Seq_ESCs_Human	0.78714512
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.78648760
89	NFYA_21822215_ChIP-Seq_K562_Human	0.77283139
90	TBL1_22424771_ChIP-Seq_293T_Human	0.76225908
91	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.75696969
92	TAF15_26573619_Chip-Seq_HEK293_Human	0.75506691
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.75062880
94	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.74373352
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.74349618
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.73781611
97	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.73074715
98	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.72408892
99	P300_19829295_ChIP-Seq_ESCs_Human	0.71331961
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.70788266

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	5.07376604
2	MP0005670_abnormal_white_adipose	3.96312523
3	MP0004185_abnormal_adipocyte_glucose	3.91531602
4	MP0010368_abnormal_lymphatic_system	3.65304332
5	MP0001879_abnormal_lymphatic_vessel	3.31521987
6	MP0000569_abnormal_digit_pigmentation	2.93788970
7	MP0005666_abnormal_adipose_tissue	2.89839019
8	MP0004134_abnormal_chest_morphology	2.79532210
9	MP0005451_abnormal_body_composition	2.47388358
10	MP0009780_abnormal_chondrocyte_physiolo	2.33380876
11	MP0004043_abnormal_pH_regulation	2.20121999
12	MP0005360_urolithiasis	2.07840620
13	MP0003806_abnormal_nucleotide_metabolis	2.06458436
14	MP0003868_abnormal_feces_composition	1.90713475
15	MP0008057_abnormal_DNA_replication	1.89054553
16	MP0005167_abnormal_blood-brain_barrier	1.84814048
17	MP0002006_tumorigenesis	1.84251849
18	MP0000372_irregular_coat_pigmentation	1.79433101
19	MP0010094_abnormal_chromosome_stability	1.75915703
20	MP0008872_abnormal_physiological_respon	1.75591111
21	MP0003283_abnormal_digestive_organ	1.64694131
22	MP0005085_abnormal_gallbladder_physiolo	1.63698650
23	MP0000049_abnormal_middle_ear	1.62575358
24	MP0005379_endocrine/exocrine_gland_phen	1.58372479
25	MP0003880_abnormal_central_pattern	1.57992093
26	MP0008058_abnormal_DNA_repair	1.55628852
27	MP0004130_abnormal_muscle_cell	1.54956114
28	MP0005375_adipose_tissue_phenotype	1.52606930
29	MP0001177_atelectasis	1.51167539
30	MP0004272_abnormal_basement_membrane	1.49699932
31	MP0006138_congestive_heart_failure	1.49651993
32	MP0005084_abnormal_gallbladder_morpholo	1.46120969
33	MP0009115_abnormal_fat_cell	1.46019914
34	MP0003221_abnormal_cardiomyocyte_apopto	1.45690341
35	MP0003385_abnormal_body_wall	1.42584202
36	MP0001730_embryonic_growth_arrest	1.40220449
37	MP0002971_abnormal_brown_adipose	1.39182567
38	MP0004957_abnormal_blastocyst_morpholog	1.36160876
39	MP0005330_cardiomyopathy	1.32405077
40	MP0003693_abnormal_embryo_hatching	1.31092087
41	MP0001346_abnormal_lacrimal_gland	1.27873697
42	MP0003011_delayed_dark_adaptation	1.26164798
43	MP0002184_abnormal_innervation	1.20563727
44	MP0004084_abnormal_cardiac_muscle	1.15325790
45	MP0002876_abnormal_thyroid_physiology	1.13985524
46	MP0008007_abnormal_cellular_replicative	1.13950755
47	MP0002127_abnormal_cardiovascular_syste	1.12315938
48	MP0003567_abnormal_fetal_cardiomyocyte	1.10352677
49	MP0003186_abnormal_redox_activity	1.08761743
50	MP0001915_intracranial_hemorrhage	1.08096538
51	MP0006072_abnormal_retinal_apoptosis	1.04592911
52	MP0003935_abnormal_craniofacial_develop	1.04229933
53	MP0002837_dystrophic_cardiac_calcinosis	1.03311102
54	MP0006036_abnormal_mitochondrial_physio	1.01035825
55	MP0004036_abnormal_muscle_relaxation	1.00056259
56	MP0000013_abnormal_adipose_tissue	0.97049772
57	MP0003755_abnormal_palate_morphology	0.92933699
58	MP0008932_abnormal_embryonic_tissue	0.91630134
59	MP0002970_abnormal_white_adipose	0.91375181
60	MP0005257_abnormal_intraocular_pressure	0.90480516
61	MP0001661_extended_life_span	0.90252748
62	MP0003938_abnormal_ear_development	0.89580342
63	MP0002269_muscular_atrophy	0.88497614
64	MP0003252_abnormal_bile_duct	0.87654414
65	MP0002733_abnormal_thermal_nociception	0.86988329
66	MP0005187_abnormal_penis_morphology	0.86203744
67	MP0002102_abnormal_ear_morphology	0.86060367
68	MP0002166_altered_tumor_susceptibility	0.85928644
69	MP0004233_abnormal_muscle_weight	0.85232070
70	MP0002233_abnormal_nose_morphology	0.81006828
71	MP0002751_abnormal_autonomic_nervous	0.79922348
72	MP0002090_abnormal_vision	0.77214617
73	MP0005385_cardiovascular_system_phenoty	0.77102246
74	MP0001544_abnormal_cardiovascular_syste	0.77102246
75	MP0000749_muscle_degeneration	0.77091865
76	MP0003937_abnormal_limbs/digits/tail_de	0.76821434
77	MP0002108_abnormal_muscle_morphology	0.76158561
78	MP0002132_abnormal_respiratory_system	0.75708070
79	MP0000733_abnormal_muscle_development	0.75014290
80	MP0002111_abnormal_tail_morphology	0.74966601
81	MP0006035_abnormal_mitochondrial_morpho	0.74054645
82	MP0003077_abnormal_cell_cycle	0.72856526
83	MP0005408_hypopigmentation	0.72618827
84	MP0010329_abnormal_lipoprotein_level	0.68844559
85	MP0003136_yellow_coat_color	0.67880619
86	MP0005171_absent_coat_pigmentation	0.67464949
87	MP0001943_abnormal_respiration	0.66666693
88	MP0002938_white_spotting	0.66534681
89	MP0001286_abnormal_eye_development	0.66458657
90	MP0005501_abnormal_skin_physiology	0.66346963
91	MP0001666_abnormal_nutrient_absorption	0.64011757
92	MP0009250_abnormal_appendicular_skeleto	0.63632424
93	MP0001293_anophthalmia	0.63299669
94	MP0005253_abnormal_eye_physiology	0.63093191
95	MP0000566_synostosis	0.61589678
96	MP0005075_abnormal_melanosome_morpholog	0.60883200
97	MP0000647_abnormal_sebaceous_gland	0.60253844
98	MP0005620_abnormal_muscle_contractility	0.60151682
99	MP0003984_embryonic_growth_retardation	0.60126100
100	MP0000762_abnormal_tongue_morphology	0.58654992

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Late onset (HP:0003584)	4.49205767
2	Hypothermia (HP:0002045)	4.46697991
3	Limb dystonia (HP:0002451)	3.85705099
4	Retinal dysplasia (HP:0007973)	3.76086777
5	Neonatal hypoglycemia (HP:0001998)	3.56759510
6	Abnormal pupillary function (HP:0007686)	3.44228919
7	Mesangial abnormality (HP:0001966)	3.30458784
8	Limb hypertonia (HP:0002509)	3.28560233
9	Cerebral hemorrhage (HP:0001342)	3.23840228
10	Arterial tortuosity (HP:0005116)	3.15940541
11	B lymphocytopenia (HP:0010976)	2.92119086
12	Severe combined immunodeficiency (HP:0004430)	2.85298599
13	Large for gestational age (HP:0001520)	2.77409252
14	Cupped ear (HP:0000378)	2.71348123
15	Vascular tortuosity (HP:0004948)	2.65313001
16	Combined immunodeficiency (HP:0005387)	2.55888191
17	Cerebral edema (HP:0002181)	2.48659610
18	Irregular epiphyses (HP:0010582)	2.46990584
19	Gonadotropin excess (HP:0000837)	2.45927383
20	Hyperglycinemia (HP:0002154)	2.40626247
21	Nephroblastoma (Wilms tumor) (HP:0002667)	2.39773610
22	Areflexia of lower limbs (HP:0002522)	2.37190855
23	Hepatic necrosis (HP:0002605)	2.35076022
24	Embryonal renal neoplasm (HP:0011794)	2.31834534
25	Horizontal nystagmus (HP:0000666)	2.29463312
26	Focal motor seizures (HP:0011153)	2.19378462
27	Congenital stationary night blindness (HP:0007642)	2.16857219
28	Round ear (HP:0100830)	2.15560696
29	Visceral angiomatosis (HP:0100761)	2.13848788
30	Asymmetry of the thorax (HP:0001555)	2.12718165
31	Chronic sinusitis (HP:0011109)	2.11867437
32	Increased serum pyruvate (HP:0003542)	2.10763951
33	Stenosis of the external auditory canal (HP:0000402)	2.10134974
34	Thyroiditis (HP:0100646)	2.09572062
35	Hypoglycemic coma (HP:0001325)	2.09116835
36	Gout (HP:0001997)	2.08764549
37	Abnormality of the left ventricular outflow tract (HP:0011103)	2.08428814
38	Subaortic stenosis (HP:0001682)	2.08428814
39	Hemangiomatosis (HP:0007461)	2.06969250
40	Abnormality of dentin (HP:0010299)	2.04112398
41	Mitochondrial inheritance (HP:0001427)	2.03695467
42	Ependymoma (HP:0002888)	2.02742207
43	Increased CSF lactate (HP:0002490)	2.02405703
44	Rimmed vacuoles (HP:0003805)	1.99632105
45	Aortic dissection (HP:0002647)	1.99358255
46	Decreased central vision (HP:0007663)	1.98326270
47	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.97436680
48	Acute encephalopathy (HP:0006846)	1.97264185
49	Acute necrotizing encephalopathy (HP:0006965)	1.96247048
50	Striae distensae (HP:0001065)	1.94594667
51	Benign neoplasm of the central nervous system (HP:0100835)	1.94474864
52	Bundle branch block (HP:0011710)	1.92397764
53	Pancytopenia (HP:0001876)	1.92228373
54	Hepatocellular necrosis (HP:0001404)	1.88190050
55	Aortic aneurysm (HP:0004942)	1.87916015
56	Lipid accumulation in hepatocytes (HP:0006561)	1.87640730
57	Abnormality of B cell number (HP:0010975)	1.87286520
58	Exertional dyspnea (HP:0002875)	1.85952637
59	Aplastic anemia (HP:0001915)	1.85909863
60	Acute hepatic failure (HP:0006554)	1.85672647
61	Increased hepatocellular lipid droplets (HP:0006565)	1.85283835
62	Pigmentary retinal degeneration (HP:0001146)	1.84787396
63	Constricted visual fields (HP:0001133)	1.83906594
64	Abnormality of cells of the erythroid lineage (HP:0012130)	1.83338914
65	Poor eye contact (HP:0000817)	1.82631940
66	Increased nuchal translucency (HP:0010880)	1.80992945
67	Abnormality of incisor morphology (HP:0011063)	1.79105221
68	Small epiphyses (HP:0010585)	1.78526308
69	Protrusio acetabuli (HP:0003179)	1.77834899
70	Absent eyebrow (HP:0002223)	1.77802233
71	Progressive macrocephaly (HP:0004481)	1.77739181
72	Myoglobinuria (HP:0002913)	1.74416082
73	Renal cortical cysts (HP:0000803)	1.74338515
74	Hypobetalipoproteinemia (HP:0003563)	1.73287405
75	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.73099228
76	Type II lissencephaly (HP:0007260)	1.72653515
77	Hemiparesis (HP:0001269)	1.70001316
78	Renal Fanconi syndrome (HP:0001994)	1.69801251
79	Medial flaring of the eyebrow (HP:0010747)	1.69103837
80	Large earlobe (HP:0009748)	1.68637523
81	Microvesicular hepatic steatosis (HP:0001414)	1.66883827
82	Nasal speech (HP:0001611)	1.66532945
83	Spinal rigidity (HP:0003306)	1.65962881
84	Abnormality of urine glucose concentration (HP:0011016)	1.64893716
85	Glycosuria (HP:0003076)	1.64893716
86	Generalized aminoaciduria (HP:0002909)	1.64841264
87	Hypoplastic scapulae (HP:0000882)	1.62949200
88	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.62949200
89	Prominent supraorbital ridges (HP:0000336)	1.62593148
90	Increased muscle lipid content (HP:0009058)	1.61070735
91	Wide intermamillary distance (HP:0006610)	1.60950053
92	Abnormality of the incisor (HP:0000676)	1.60464924
93	Abnormality of the lacrimal duct (HP:0011481)	1.60158964
94	Thyroid-stimulating hormone excess (HP:0002925)	1.59254842
95	Lissencephaly (HP:0001339)	1.58208455
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.57409512
97	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.56821874
98	Humeroradial synostosis (HP:0003041)	1.55838854
99	Synostosis involving the elbow (HP:0003938)	1.55838854
100	Megaloblastic anemia (HP:0001889)	1.55453022

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	5.44801181
2	KDR	3.65132016
3	VRK2	3.29222520
4	CDK8	3.05754589
5	BRD4	2.87875788
6	ILK	2.86428290
7	TESK2	2.49098889
8	STK38L	2.28006754
9	RPS6KA4	2.20374312
10	BMPR1B	2.18836240
11	PINK1	2.17048134
12	CDC7	2.15990173
13	TESK1	2.09850137
14	BUB1	2.05983338
15	CDK9	1.93721346
16	EIF2AK1	1.89918099
17	MYLK	1.86551724
18	LATS2	1.86215394
19	MST4	1.81449280
20	TAF1	1.79686683
21	VRK1	1.76390380
22	LATS1	1.75013278
23	DMPK	1.74258648
24	LIMK1	1.69296586
25	MAP3K12	1.68593488
26	TLK1	1.64163879
27	TIE1	1.62674207
28	NUAK1	1.55399121
29	NEK1	1.48726246
30	DAPK1	1.37685374
31	EPHB2	1.30281539
32	NEK2	1.17394367
33	CDK7	1.13920701
34	DAPK3	1.13559370
35	SRPK1	1.03064854
36	PTK2B	0.98107099
37	PAK6	0.97070291
38	BCKDK	0.96211689
39	CDK3	0.92075687
40	TGFBR1	0.86162750
41	PKN1	0.84483218
42	WNK4	0.84410879
43	MAP3K6	0.82738191
44	STK39	0.80211470
45	OBSCN	0.79504606
46	AURKB	0.75634907
47	DYRK3	0.74228183
48	NEK6	0.71137757
49	BCR	0.68594468
50	TSSK6	0.68487530
51	ZAK	0.65938860
52	CSNK1A1L	0.65806269
53	PAK4	0.65289023
54	PTK2	0.65113694
55	WNK3	0.65069051
56	FGFR2	0.64636278
57	PDGFRA	0.63122342
58	PAK1	0.60931688
59	MAP2K7	0.58904204
60	ROCK1	0.57985259
61	ATR	0.56949276
62	CSNK1G3	0.53693889
63	IRAK3	0.52518971
64	TTK	0.51081338
65	CDK14	0.51053893
66	SMG1	0.50337921
67	STK38	0.50305791
68	PHKG1	0.50079311
69	PHKG2	0.50079311
70	ERBB2	0.47471920
71	CDK12	0.47341479
72	PLK4	0.46273650
73	ICK	0.46076224
74	PLK3	0.45314109
75	CDK15	0.45128271
76	SIK2	0.45044499
77	PLK1	0.44480350
78	MET	0.43339577
79	CSNK1G1	0.43243122
80	ADRBK2	0.43157786
81	CDK4	0.42818164
82	MAPKAPK3	0.41354858
83	CDK18	0.41083345
84	CDK11A	0.41032563
85	AKT2	0.40584966
86	PNCK	0.40551937
87	MELK	0.40485859
88	CSNK1G2	0.40019587
89	NME1	0.39741377
90	WEE1	0.39072668
91	MARK1	0.38826315
92	CAMK2B	0.38272602
93	MAPK12	0.37484626
94	EIF2AK3	0.35714886
95	ERBB4	0.34842623
96	NTRK2	0.34715540
97	MAP3K7	0.33938436
98	PRKCE	0.33623559
99	TGFBR2	0.32283237
100	RET	0.32082841

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.68078944
2	Proteasome_Homo sapiens_hsa03050	3.50543407
3	Fatty acid elongation_Homo sapiens_hsa00062	3.22935498
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.19141282
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.79623421
6	Phenylalanine metabolism_Homo sapiens_hsa00360	2.68808455
7	DNA replication_Homo sapiens_hsa03030	2.61313267
8	Propanoate metabolism_Homo sapiens_hsa00640	2.21686592
9	Fatty acid metabolism_Homo sapiens_hsa01212	2.14535905
10	Parkinsons disease_Homo sapiens_hsa05012	2.06234233
11	One carbon pool by folate_Homo sapiens_hsa00670	1.86721236
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.80090738
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79887159
14	Spliceosome_Homo sapiens_hsa03040	1.78849526
15	Base excision repair_Homo sapiens_hsa03410	1.73799476
16	Tyrosine metabolism_Homo sapiens_hsa00350	1.71354632
17	RNA transport_Homo sapiens_hsa03013	1.70172538
18	Basal transcription factors_Homo sapiens_hsa03022	1.54444113
19	RNA polymerase_Homo sapiens_hsa03020	1.49682892
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.38857247
21	Mismatch repair_Homo sapiens_hsa03430	1.38261446
22	Ribosome_Homo sapiens_hsa03010	1.36102940
23	Huntingtons disease_Homo sapiens_hsa05016	1.35633950
24	Histidine metabolism_Homo sapiens_hsa00340	1.34273748
25	Nicotine addiction_Homo sapiens_hsa05033	1.33298291
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32277871
27	Butanoate metabolism_Homo sapiens_hsa00650	1.30330270
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.23718314
29	GABAergic synapse_Homo sapiens_hsa04727	1.20919181
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.18865501
31	Alzheimers disease_Homo sapiens_hsa05010	1.11399938
32	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.06994471
33	Adherens junction_Homo sapiens_hsa04520	1.05181616
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04944137
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.04324879
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02656895
37	Purine metabolism_Homo sapiens_hsa00230	1.02239120
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00979432
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97795635
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.97012197
41	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.96332128
42	Protein export_Homo sapiens_hsa03060	0.90457953
43	PPAR signaling pathway_Homo sapiens_hsa03320	0.89837341
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.89822237
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88559092
46	Amphetamine addiction_Homo sapiens_hsa05031	0.87940099
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87828503
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.87766464
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.83575710
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83480662
51	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.83191394
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.79676720
53	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.79475608
54	Glutathione metabolism_Homo sapiens_hsa00480	0.78106992
55	African trypanosomiasis_Homo sapiens_hsa05143	0.77320605
56	RNA degradation_Homo sapiens_hsa03018	0.75743052
57	Cocaine addiction_Homo sapiens_hsa05030	0.71809892
58	Fatty acid degradation_Homo sapiens_hsa00071	0.70244907
59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.69781796
60	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.67578311
61	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.64842381
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64541346
63	Morphine addiction_Homo sapiens_hsa05032	0.62542639
64	Shigellosis_Homo sapiens_hsa05131	0.61337647
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61317347
66	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.61166276
67	Cell cycle_Homo sapiens_hsa04110	0.60268208
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59698144
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58853117
70	Axon guidance_Homo sapiens_hsa04360	0.58472710
71	Tight junction_Homo sapiens_hsa04530	0.58415093
72	Folate biosynthesis_Homo sapiens_hsa00790	0.53759357
73	Serotonergic synapse_Homo sapiens_hsa04726	0.53049888
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52620745
75	Renin secretion_Homo sapiens_hsa04924	0.50865016
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48676873
77	Focal adhesion_Homo sapiens_hsa04510	0.47909479
78	Oocyte meiosis_Homo sapiens_hsa04114	0.46669004
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.45372904
80	Phototransduction_Homo sapiens_hsa04744	0.45055784
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42603446
82	Peroxisome_Homo sapiens_hsa04146	0.42420771
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41657717
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40864862
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.40838625
86	Olfactory transduction_Homo sapiens_hsa04740	0.40510125
87	Gap junction_Homo sapiens_hsa04540	0.39715626
88	Melanoma_Homo sapiens_hsa05218	0.38947384
89	Metabolic pathways_Homo sapiens_hsa01100	0.37041709
90	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.36238801
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35368125
92	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.35273570
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.33809705
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.33690709
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33597005
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33436911
97	Homologous recombination_Homo sapiens_hsa03440	0.33370547
98	Circadian entrainment_Homo sapiens_hsa04713	0.32536245
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.31751433
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31556502

HMGN2P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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