ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.54433196
2	ATP synthesis coupled proton transport (GO:0015986)	5.54433196
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.47858066
4	DNA deamination (GO:0045006)	5.18023628
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.88950471
6	preassembly of GPI anchor in ER membrane (GO:0016254)	4.38013069
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.37917680
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.37917680
9	respiratory electron transport chain (GO:0022904)	4.31484589
10	protein complex biogenesis (GO:0070271)	4.29063497
11	electron transport chain (GO:0022900)	4.27893000
12	GPI anchor biosynthetic process (GO:0006506)	4.09686878
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.09080266
14	NADH dehydrogenase complex assembly (GO:0010257)	4.09080266
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.09080266
16	protein neddylation (GO:0045116)	4.06883689
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.06620424
18	GPI anchor metabolic process (GO:0006505)	3.97937873
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.95216806
20	platelet dense granule organization (GO:0060155)	3.91863115
21	proteasome assembly (GO:0043248)	3.89864357
22	mannosylation (GO:0097502)	3.87301167
23	chaperone-mediated protein transport (GO:0072321)	3.72805287
24	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.51584927
25	protein-cofactor linkage (GO:0018065)	3.49922397
26	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.45751657
27	respiratory chain complex IV assembly (GO:0008535)	3.38412732
28	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.34445423
29	regulation of mitotic spindle checkpoint (GO:1903504)	3.34445423
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.30956253
31	CENP-A containing nucleosome assembly (GO:0034080)	3.28996192
32	cytochrome complex assembly (GO:0017004)	3.28900903
33	chromatin remodeling at centromere (GO:0031055)	3.26432650
34	cytidine metabolic process (GO:0046087)	3.25394283
35	cytidine catabolic process (GO:0006216)	3.25394283
36	cytidine deamination (GO:0009972)	3.25394283
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.22441754
38	water-soluble vitamin biosynthetic process (GO:0042364)	3.22438841
39	hydrogen ion transmembrane transport (GO:1902600)	3.21560547
40	ATP biosynthetic process (GO:0006754)	3.15876577
41	C-terminal protein lipidation (GO:0006501)	3.14680482
42	proton transport (GO:0015992)	3.11124943
43	kynurenine metabolic process (GO:0070189)	3.06470331
44	hydrogen transport (GO:0006818)	3.05919315
45	L-methionine salvage (GO:0071267)	3.05470946
46	L-methionine biosynthetic process (GO:0071265)	3.05470946
47	amino acid salvage (GO:0043102)	3.05470946
48	peptidyl-histidine modification (GO:0018202)	3.05438722
49	tryptophan metabolic process (GO:0006568)	3.05046144
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.04552177
51	S-adenosylmethionine metabolic process (GO:0046500)	3.02872738
52	cullin deneddylation (GO:0010388)	3.00985874
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.00856213
54	regulation of cellular amino acid metabolic process (GO:0006521)	3.00608585
55	behavioral response to nicotine (GO:0035095)	2.96339729
56	pseudouridine synthesis (GO:0001522)	2.94757444
57	sequestering of actin monomers (GO:0042989)	2.94519877
58	positive regulation of prostaglandin secretion (GO:0032308)	2.93403153
59	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.92576530
60	ribosomal small subunit assembly (GO:0000028)	2.92438457
61	oxidative phosphorylation (GO:0006119)	2.91818806
62	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.89935690
63	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.89063647
64	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.89063647
65	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.89063647
66	fucose catabolic process (GO:0019317)	2.89048572
67	L-fucose metabolic process (GO:0042354)	2.89048572
68	L-fucose catabolic process (GO:0042355)	2.89048572
69	protein deneddylation (GO:0000338)	2.89047988
70	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.88935538
71	rRNA modification (GO:0000154)	2.87602623
72	DNA replication-dependent nucleosome organization (GO:0034723)	2.87292411
73	DNA replication-dependent nucleosome assembly (GO:0006335)	2.87292411
74	C-terminal protein amino acid modification (GO:0018410)	2.85677050
75	indole-containing compound catabolic process (GO:0042436)	2.85281577
76	indolalkylamine catabolic process (GO:0046218)	2.85281577
77	tryptophan catabolic process (GO:0006569)	2.85281577
78	protein targeting to mitochondrion (GO:0006626)	2.83074184
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.82858835
80	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.81620212
81	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.81620212
82	base-excision repair, AP site formation (GO:0006285)	2.78664787
83	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.78289463
84	termination of RNA polymerase III transcription (GO:0006386)	2.78289463
85	regulation of mitochondrial translation (GO:0070129)	2.77823461
86	indolalkylamine metabolic process (GO:0006586)	2.77349544
87	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.74902491
88	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.74657890
89	establishment of protein localization to mitochondrion (GO:0072655)	2.73514436
90	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.73167695
91	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.72796699
92	histone exchange (GO:0043486)	2.72287960
93	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.72171004
94	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.72171004
95	tRNA processing (GO:0008033)	2.71123881
96	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.70070632
97	iron-sulfur cluster assembly (GO:0016226)	2.68507917
98	metallo-sulfur cluster assembly (GO:0031163)	2.68507917
99	maturation of 5.8S rRNA (GO:0000460)	2.67936016
100	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.67052710

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.60817254
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.22274697
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.52962021
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.24936424
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.19656145
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12623009
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.01877652
8	VDR_22108803_ChIP-Seq_LS180_Human	2.90550290
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.83172080
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76430232
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70328997
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.60225685
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59701372
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.55379758
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.54104608
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.48897139
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.33783919
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.32143148
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.29905993
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.22742303
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.08634832
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07043406
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.93660877
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.90833248
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.89541873
26	EWS_26573619_Chip-Seq_HEK293_Human	1.80568378
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.72461751
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.65644108
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63548892
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.61243966
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60462862
32	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.58666176
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.58016900
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53179429
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.50726766
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50683801
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50140749
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.48521838
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42047390
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.41722219
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41177069
42	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.38664131
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38018944
44	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.37547078
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.36948117
46	AR_20517297_ChIP-Seq_VCAP_Human	1.36532289
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36038784
48	FUS_26573619_Chip-Seq_HEK293_Human	1.35318557
49	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34714635
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32179607
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31250574
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31250574
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28115732
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.27288184
55	E2F7_22180533_ChIP-Seq_HELA_Human	1.26452562
56	GATA3_26560356_Chip-Seq_TH2_Human	1.24774561
57	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.22853655
58	P300_19829295_ChIP-Seq_ESCs_Human	1.21414910
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.20695356
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.19413075
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.18168347
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18168347
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.16043770
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12699474
65	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08996048
66	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.08201205
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07661908
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07661908
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06749393
70	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06005277
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04797349
72	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.04622387
73	NCOR_22424771_ChIP-Seq_293T_Human	1.03455364
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03410396
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02740487
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02626146
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02168444
78	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00679141
79	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00343861
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99198819
81	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99061501
82	ERG_20517297_ChIP-Seq_VCAP_Human	0.98663863
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97756953
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97716378
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96776306
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96561927
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95971386
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95830467
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95541893
90	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.92788979
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.92210277
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91401025
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90505046
94	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89277069
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88174153
96	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.86902015
97	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.86397216
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86386010
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86355156
100	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.85814514

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	3.44081708
2	MP0004147_increased_porphyrin_level	3.33938613
3	MP0005646_abnormal_pituitary_gland	2.70966007
4	MP0000372_irregular_coat_pigmentation	2.50279089
5	MP0002837_dystrophic_cardiac_calcinosis	2.47602322
6	MP0003806_abnormal_nucleotide_metabolis	2.31351764
7	MP0008877_abnormal_DNA_methylation	2.26928896
8	MP0005671_abnormal_response_to	2.25877633
9	MP0003786_premature_aging	2.15793133
10	MP0001529_abnormal_vocalization	2.13151126
11	MP0008875_abnormal_xenobiotic_pharmacok	2.10040208
12	MP0001986_abnormal_taste_sensitivity	1.96861350
13	MP0005253_abnormal_eye_physiology	1.93781219
14	MP0008872_abnormal_physiological_respon	1.93745069
15	MP0002736_abnormal_nociception_after	1.93403213
16	MP0001968_abnormal_touch/_nociception	1.91705226
17	MP0004885_abnormal_endolymph	1.88037462
18	MP0005084_abnormal_gallbladder_morpholo	1.86883626
19	MP0005075_abnormal_melanosome_morpholog	1.86543478
20	MP0002102_abnormal_ear_morphology	1.86136527
21	MP0006292_abnormal_olfactory_placode	1.84206148
22	MP0006036_abnormal_mitochondrial_physio	1.81225722
23	MP0005551_abnormal_eye_electrophysiolog	1.80772771
24	MP0008995_early_reproductive_senescence	1.78815544
25	MP0010094_abnormal_chromosome_stability	1.78669918
26	MP0008058_abnormal_DNA_repair	1.78459916
27	MP0003011_delayed_dark_adaptation	1.78099730
28	MP0001835_abnormal_antigen_presentation	1.77524268
29	MP0003195_calcinosis	1.73163435
30	MP0002876_abnormal_thyroid_physiology	1.70095008
31	MP0003724_increased_susceptibility_to	1.68327183
32	MP0009379_abnormal_foot_pigmentation	1.65277786
33	MP0001919_abnormal_reproductive_system	1.60036843
34	MP0004142_abnormal_muscle_tone	1.52963613
35	MP0008789_abnormal_olfactory_epithelium	1.52174637
36	MP0002095_abnormal_skin_pigmentation	1.47178595
37	MP0005389_reproductive_system_phenotype	1.45354697
38	MP0003186_abnormal_redox_activity	1.42529648
39	MP0001905_abnormal_dopamine_level	1.40612449
40	MP0003878_abnormal_ear_physiology	1.38974966
41	MP0005377_hearing/vestibular/ear_phenot	1.38974966
42	MP0002148_abnormal_hypersensitivity_rea	1.34711782
43	MP0005645_abnormal_hypothalamus_physiol	1.33641786
44	MP0006276_abnormal_autonomic_nervous	1.30875974
45	MP0003718_maternal_effect	1.30786964
46	MP0001764_abnormal_homeostasis	1.25618974
47	MP0003880_abnormal_central_pattern	1.25067845
48	MP0006035_abnormal_mitochondrial_morpho	1.25037450
49	MP0003787_abnormal_imprinting	1.22013092
50	MP0005379_endocrine/exocrine_gland_phen	1.19944316
51	MP0003646_muscle_fatigue	1.17942848
52	MP0002163_abnormal_gland_morphology	1.16750479
53	MP0001501_abnormal_sleep_pattern	1.11712144
54	MP0001984_abnormal_olfaction	1.11537139
55	MP0002272_abnormal_nervous_system	1.09260910
56	MP0009745_abnormal_behavioral_response	1.07960663
57	MP0009764_decreased_sensitivity_to	1.07334399
58	MP0004145_abnormal_muscle_electrophysio	1.06144792
59	MP0001188_hyperpigmentation	1.04065601
60	MP0005332_abnormal_amino_acid	1.03994844
61	MP0009785_altered_susceptibility_to	1.03109580
62	MP0001800_abnormal_humoral_immune	1.02202600
63	MP0009046_muscle_twitch	1.00466304
64	MP0005636_abnormal_mineral_homeostasis	1.00346713
65	MP0000685_abnormal_immune_system	0.99581577
66	MP0002638_abnormal_pupillary_reflex	0.98812326
67	MP0005174_abnormal_tail_pigmentation	0.98615107
68	MP0000427_abnormal_hair_cycle	0.97847346
69	MP0005167_abnormal_blood-brain_barrier	0.97669934
70	MP0005000_abnormal_immune_tolerance	0.97655614
71	MP0000631_abnormal_neuroendocrine_gland	0.94346608
72	MP0003866_abnormal_defecation	0.94333111
73	MP0005360_urolithiasis	0.87928582
74	MP0002938_white_spotting	0.87705921
75	MP0001486_abnormal_startle_reflex	0.86472430
76	MP0005410_abnormal_fertilization	0.86166558
77	MP0002723_abnormal_immune_serum	0.85674527
78	MP0002138_abnormal_hepatobiliary_system	0.83475634
79	MP0002751_abnormal_autonomic_nervous	0.83301476
80	MP0003252_abnormal_bile_duct	0.81742267
81	MP0002452_abnormal_antigen_presenting	0.79047832
82	MP0005499_abnormal_olfactory_system	0.78007279
83	MP0005394_taste/olfaction_phenotype	0.78007279
84	MP0001929_abnormal_gametogenesis	0.77937255
85	MP0002160_abnormal_reproductive_system	0.77223425
86	MP0002234_abnormal_pharynx_morphology	0.76459093
87	MP0002210_abnormal_sex_determination	0.76254654
88	MP0002909_abnormal_adrenal_gland	0.75445274
89	MP0000465_gastrointestinal_hemorrhage	0.74206698
90	MP0005195_abnormal_posterior_eye	0.73761390
91	MP0000653_abnormal_sex_gland	0.73557316
92	MP0001765_abnormal_ion_homeostasis	0.73414253
93	MP0001485_abnormal_pinna_reflex	0.73262042
94	MP0001819_abnormal_immune_cell	0.72655140
95	MP0000230_abnormal_systemic_arterial	0.72266240
96	MP0002420_abnormal_adaptive_immunity	0.71526246
97	MP0001145_abnormal_male_reproductive	0.71358545
98	MP0000639_abnormal_adrenal_gland	0.71188439
99	MP0003137_abnormal_impulse_conducting	0.68882297
100	MP0000689_abnormal_spleen_morphology	0.68510719

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.86757993
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.35784031
3	Mitochondrial inheritance (HP:0001427)	4.35528019
4	Acute encephalopathy (HP:0006846)	4.21054270
5	Progressive macrocephaly (HP:0004481)	4.13780372
6	Hepatocellular necrosis (HP:0001404)	4.07306206
7	Increased CSF lactate (HP:0002490)	4.01745300
8	3-Methylglutaconic aciduria (HP:0003535)	3.73075202
9	Abnormality of alanine metabolism (HP:0010916)	3.70046643
10	Hyperalaninemia (HP:0003348)	3.70046643
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.70046643
12	Hepatic necrosis (HP:0002605)	3.61478915
13	Congenital, generalized hypertrichosis (HP:0004540)	3.61010651
14	Lipid accumulation in hepatocytes (HP:0006561)	3.38995467
15	Methylmalonic acidemia (HP:0002912)	3.29435987
16	Increased hepatocellular lipid droplets (HP:0006565)	3.26896983
17	Cerebral edema (HP:0002181)	3.14383350
18	Abnormality of midbrain morphology (HP:0002418)	3.09870089
19	Molar tooth sign on MRI (HP:0002419)	3.09870089
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.05565620
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.05565620
22	Pancreatic cysts (HP:0001737)	2.99067760
23	Increased serum lactate (HP:0002151)	2.98761329
24	IgG deficiency (HP:0004315)	2.87966319
25	Congenital stationary night blindness (HP:0007642)	2.83675039
26	True hermaphroditism (HP:0010459)	2.83105840
27	Lactic acidosis (HP:0003128)	2.72274773
28	Pancreatic fibrosis (HP:0100732)	2.69862287
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.69149991
30	Methylmalonic aciduria (HP:0012120)	2.65158470
31	Optic disc pallor (HP:0000543)	2.62902648
32	Medial flaring of the eyebrow (HP:0010747)	2.60748839
33	Severe combined immunodeficiency (HP:0004430)	2.59407589
34	Renal Fanconi syndrome (HP:0001994)	2.57443403
35	Abolished electroretinogram (ERG) (HP:0000550)	2.53740878
36	Nephronophthisis (HP:0000090)	2.48788812
37	Increased intramyocellular lipid droplets (HP:0012240)	2.46087345
38	Hyperglycinemia (HP:0002154)	2.44491368
39	Respiratory failure (HP:0002878)	2.37935396
40	Lethargy (HP:0001254)	2.31278824
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.27738723
42	Thyroiditis (HP:0100646)	2.24892268
43	Hypothermia (HP:0002045)	2.23204902
44	Type 2 muscle fiber atrophy (HP:0003554)	2.21262771
45	Increased muscle lipid content (HP:0009058)	2.21246011
46	Leukodystrophy (HP:0002415)	2.21143968
47	Renal cortical cysts (HP:0000803)	2.20703712
48	Congenital primary aphakia (HP:0007707)	2.20610214
49	Aplasia/hypoplasia of the uterus (HP:0008684)	2.18268494
50	Type II lissencephaly (HP:0007260)	2.16128860
51	Exertional dyspnea (HP:0002875)	2.13331919
52	Gait imbalance (HP:0002141)	2.13328172
53	Constricted visual fields (HP:0001133)	2.11713836
54	Abnormality of the renal cortex (HP:0011035)	2.10442448
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.08736555
56	Progressive microcephaly (HP:0000253)	2.07681488
57	Nephrogenic diabetes insipidus (HP:0009806)	2.07110958
58	Exercise intolerance (HP:0003546)	2.06066420
59	Abnormality of serum amino acid levels (HP:0003112)	2.00802628
60	Abnormal rod and cone electroretinograms (HP:0008323)	1.97556501
61	CNS demyelination (HP:0007305)	1.95333577
62	Combined immunodeficiency (HP:0005387)	1.95010229
63	Pendular nystagmus (HP:0012043)	1.93940070
64	Abnormality of the renal medulla (HP:0100957)	1.93444766
65	Abnormality of the prostate (HP:0008775)	1.92821789
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.89947685
67	Attenuation of retinal blood vessels (HP:0007843)	1.89685391
68	Abnormal number of erythroid precursors (HP:0012131)	1.89601464
69	Short tibia (HP:0005736)	1.89126509
70	Delayed CNS myelination (HP:0002188)	1.86861948
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86349384
72	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.86193949
73	Dicarboxylic aciduria (HP:0003215)	1.86193949
74	Retinal dysplasia (HP:0007973)	1.86045297
75	Sclerocornea (HP:0000647)	1.85765770
76	Aplastic anemia (HP:0001915)	1.85344396
77	Degeneration of anterior horn cells (HP:0002398)	1.84940642
78	Abnormality of the anterior horn cell (HP:0006802)	1.84940642
79	Abnormality of serine family amino acid metabolism (HP:0010894)	1.83153053
80	Abnormality of glycine metabolism (HP:0010895)	1.83153053
81	Type I transferrin isoform profile (HP:0003642)	1.82820099
82	Abnormality of vitamin B metabolism (HP:0004340)	1.82090895
83	Hypoplasia of the uterus (HP:0000013)	1.81934327
84	Abnormal protein glycosylation (HP:0012346)	1.80804776
85	Abnormal glycosylation (HP:0012345)	1.80804776
86	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.80804776
87	Abnormal protein N-linked glycosylation (HP:0012347)	1.80804776
88	Cleft eyelid (HP:0000625)	1.80099633
89	Pancytopenia (HP:0001876)	1.79247449
90	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.78483899
91	Hyperglycinuria (HP:0003108)	1.77407391
92	Abnormality of B cell number (HP:0010975)	1.77141136
93	Ketosis (HP:0001946)	1.76010073
94	Muscle fiber atrophy (HP:0100295)	1.74523766
95	Panhypogammaglobulinemia (HP:0003139)	1.73651194
96	B lymphocytopenia (HP:0010976)	1.73613540
97	Absent thumb (HP:0009777)	1.72888177
98	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.71367419
99	Abnormality of the fovea (HP:0000493)	1.67523826
100	Abnormality of cells of the erythroid lineage (HP:0012130)	1.65701442

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.20724935
2	MAP4K2	3.09463913
3	TXK	3.03677745
4	BCKDK	2.60591046
5	TLK1	2.38993910
6	TAOK3	2.34469275
7	EIF2AK3	2.22408166
8	VRK2	2.21139741
9	NUAK1	2.20591471
10	GRK1	2.10996188
11	ADRBK2	2.08103920
12	TESK2	1.99600976
13	FRK	1.98485948
14	STK16	1.92613811
15	INSRR	1.80109285
16	BMPR1B	1.74444484
17	MST4	1.69464196
18	ERBB3	1.61367259
19	SRPK1	1.55501202
20	BUB1	1.53690352
21	WNK3	1.47831318
22	CSNK1G3	1.47736991
23	TRIM28	1.46507871
24	EIF2AK1	1.45507147
25	KDR	1.40866827
26	PLK2	1.36584097
27	BMPR2	1.36400060
28	OXSR1	1.35932947
29	PLK4	1.35143681
30	CDK8	1.31820732
31	GRK6	1.28573424
32	WNK4	1.28432201
33	VRK1	1.28326146
34	RPS6KA4	1.28029739
35	PINK1	1.25519264
36	NEK1	1.24284968
37	CSNK1G2	1.21059324
38	CCNB1	1.14404067
39	DYRK2	1.11806698
40	KIT	1.08427746
41	CSNK1G1	1.07062949
42	STK39	1.05567709
43	PLK3	1.03272208
44	CSNK1A1L	1.01152081
45	GRK7	1.01142958
46	BCR	0.99884203
47	TIE1	0.99306160
48	PHKG1	0.94089501
49	PHKG2	0.94089501
50	NME1	0.91606692
51	EIF2AK2	0.88494624
52	MAP2K7	0.88190747
53	DAPK2	0.87713900
54	RPS6KA5	0.86405533
55	CDC7	0.85779941
56	LIMK1	0.82965197
57	IKBKB	0.81679584
58	CDK19	0.78426949
59	MAPK13	0.77811198
60	DAPK1	0.75982448
61	MAP3K12	0.75876248
62	TEC	0.74732842
63	SYK	0.71757159
64	MAP2K2	0.70369576
65	MAP3K4	0.70133490
66	ATR	0.69731614
67	AURKB	0.68650786
68	MAP4K1	0.65206570
69	MKNK1	0.63500405
70	ITK	0.62262242
71	DYRK3	0.61241516
72	CSF1R	0.60808312
73	TNK2	0.58020231
74	LYN	0.56369954
75	PRKCE	0.55506090
76	FES	0.55318681
77	CSNK2A1	0.55215106
78	ACVR1B	0.53209465
79	PLK1	0.51273218
80	MAPKAPK3	0.49129443
81	PRKCQ	0.49119335
82	CHEK2	0.48217643
83	ADRBK1	0.48187222
84	GRK5	0.46547194
85	FLT3	0.45676595
86	PIM2	0.45517252
87	PIM1	0.45135850
88	CSNK1A1	0.44828526
89	CSNK2A2	0.44592997
90	MAP2K6	0.44333950
91	EPHA3	0.44267920
92	TSSK6	0.43883032
93	MATK	0.43501031
94	ABL2	0.42256179
95	PDK2	0.41106449
96	IGF1R	0.37845159
97	OBSCN	0.37621636
98	MUSK	0.37429862
99	LCK	0.36972360
100	PRKACA	0.36889710

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.08893171
2	Proteasome_Homo sapiens_hsa03050	3.74830706
3	Protein export_Homo sapiens_hsa03060	3.40657811
4	Parkinsons disease_Homo sapiens_hsa05012	3.39430503
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.78020285
6	Ribosome_Homo sapiens_hsa03010	2.34371652
7	RNA polymerase_Homo sapiens_hsa03020	2.25903310
8	Huntingtons disease_Homo sapiens_hsa05016	2.21978594
9	Alzheimers disease_Homo sapiens_hsa05010	2.20461007
10	Homologous recombination_Homo sapiens_hsa03440	2.09975136
11	Asthma_Homo sapiens_hsa05310	2.05434900
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.01964405
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92155973
14	Mismatch repair_Homo sapiens_hsa03430	1.91273883
15	DNA replication_Homo sapiens_hsa03030	1.90869416
16	One carbon pool by folate_Homo sapiens_hsa00670	1.86257172
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.85209094
18	Caffeine metabolism_Homo sapiens_hsa00232	1.84303490
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61907873
20	RNA degradation_Homo sapiens_hsa03018	1.47351499
21	Spliceosome_Homo sapiens_hsa03040	1.45856776
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45802393
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42512134
24	Phototransduction_Homo sapiens_hsa04744	1.40871801
25	Basal transcription factors_Homo sapiens_hsa03022	1.40622774
26	Base excision repair_Homo sapiens_hsa03410	1.40470608
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40042820
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34693484
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.34692260
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34225834
31	Primary immunodeficiency_Homo sapiens_hsa05340	1.34036018
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.33657278
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.30408071
34	Propanoate metabolism_Homo sapiens_hsa00640	1.28229968
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.26337975
36	Allograft rejection_Homo sapiens_hsa05330	1.25442493
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.23709639
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.23377929
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21066963
40	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.18927039
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.13087264
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11906128
43	Butanoate metabolism_Homo sapiens_hsa00650	1.08950653
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08019353
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07810970
46	Sulfur metabolism_Homo sapiens_hsa00920	1.06311207
47	Nitrogen metabolism_Homo sapiens_hsa00910	1.00673860
48	Purine metabolism_Homo sapiens_hsa00230	0.99739775
49	Peroxisome_Homo sapiens_hsa04146	0.99205693
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90650656
51	RNA transport_Homo sapiens_hsa03013	0.89180383
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88463799
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86899803
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86794989
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86415918
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82306625
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81558164
58	Folate biosynthesis_Homo sapiens_hsa00790	0.81434569
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74442038
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74033876
61	Metabolic pathways_Homo sapiens_hsa01100	0.72771254
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.72592737
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.71499851
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70595982
65	Regulation of autophagy_Homo sapiens_hsa04140	0.70239641
66	Fatty acid elongation_Homo sapiens_hsa00062	0.66041995
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.64920264
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.64534208
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.63638297
70	Sulfur relay system_Homo sapiens_hsa04122	0.60733159
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60549357
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59932398
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59617374
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58162078
75	Nicotine addiction_Homo sapiens_hsa05033	0.57178013
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.56209368
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54287011
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54141285
79	Olfactory transduction_Homo sapiens_hsa04740	0.53171538
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52899566
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.50730952
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49826397
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48949413
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46771379
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.46176267
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44925378
87	Retinol metabolism_Homo sapiens_hsa00830	0.42482028
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39658816
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39609428
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39244597
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.39180789
92	Fatty acid degradation_Homo sapiens_hsa00071	0.38859882
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.37724463
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37181169
95	Morphine addiction_Homo sapiens_hsa05032	0.36657561
96	Taste transduction_Homo sapiens_hsa04742	0.36072989
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35598711
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35068185
99	Glutathione metabolism_Homo sapiens_hsa00480	0.33995910
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.28848300

HMGN2P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »