Rank | Gene Set | Z-score |
---|---|---|
1 | positive regulation of sodium ion transmembrane transporter activity (GO:2000651) | 7.79729631 |
2 | growth hormone secretion (GO:0030252) | 7.51281283 |
3 | regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108) | 7.27435535 |
4 | negative regulation of interleukin-1 beta production (GO:0032691) | 7.19323007 |
5 | adult feeding behavior (GO:0008343) | 6.82328334 |
6 | positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568) | 6.30470713 |
7 | water-soluble vitamin biosynthetic process (GO:0042364) | 6.01619398 |
8 | negative regulation of interleukin-1 production (GO:0032692) | 5.92890194 |
9 | DNA deamination (GO:0045006) | 5.82194663 |
10 | positive regulation of sodium ion transmembrane transport (GO:1902307) | 5.44154662 |
11 | regulation of response to food (GO:0032095) | 5.41411231 |
12 | adaptation of signaling pathway (GO:0023058) | 5.20414781 |
13 | cytidine deamination (GO:0009972) | 5.19649277 |
14 | cytidine metabolic process (GO:0046087) | 5.19649277 |
15 | cytidine catabolic process (GO:0006216) | 5.19649277 |
16 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 5.16301335 |
17 | regulation of appetite (GO:0032098) | 4.85791857 |
18 | positive thymic T cell selection (GO:0045059) | 4.74312678 |
19 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.69144884 |
20 | hindbrain development (GO:0030902) | 4.58807262 |
21 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 4.41318863 |
22 | response to food (GO:0032094) | 4.37399631 |
23 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.34467501 |
24 | multicellular organism reproduction (GO:0032504) | 4.32064876 |
25 | negative regulation of T cell differentiation in thymus (GO:0033085) | 3.88554473 |
26 | cytolysis (GO:0019835) | 3.84360573 |
27 | positive regulation of gluconeogenesis (GO:0045722) | 3.82943706 |
28 | one-carbon compound transport (GO:0019755) | 3.74371178 |
29 | negative regulation of peptidyl-serine phosphorylation (GO:0033137) | 3.73740926 |
30 | regulation of insulin-like growth factor receptor signaling pathway (GO:0043567) | 3.72563126 |
31 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.65023812 |
32 | piRNA metabolic process (GO:0034587) | 3.63868434 |
33 | protein K6-linked ubiquitination (GO:0085020) | 3.48211160 |
34 | positive regulation of defense response to virus by host (GO:0002230) | 3.46470772 |
35 | regulation of mitochondrial membrane permeability (GO:0046902) | 3.43193786 |
36 | ubiquinone biosynthetic process (GO:0006744) | 3.39113449 |
37 | proteasome assembly (GO:0043248) | 3.39013185 |
38 | regulation of membrane permeability (GO:0090559) | 3.27805115 |
39 | sperm capacitation (GO:0048240) | 3.25562478 |
40 | negative regulation of mast cell activation (GO:0033004) | 3.24136631 |
41 | T cell migration (GO:0072678) | 3.23055044 |
42 | microtubule depolymerization (GO:0007019) | 3.21888571 |
43 | positive T cell selection (GO:0043368) | 3.19432092 |
44 | protein kinase B signaling (GO:0043491) | 3.18988632 |
45 | GMP metabolic process (GO:0046037) | 3.18128920 |
46 | electron transport chain (GO:0022900) | 3.10449793 |
47 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.10317709 |
48 | chaperone-mediated protein transport (GO:0072321) | 3.07961624 |
49 | auditory receptor cell stereocilium organization (GO:0060088) | 3.06689092 |
50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.06467054 |
51 | DNA demethylation (GO:0080111) | 3.04243630 |
52 | thymic T cell selection (GO:0045061) | 3.01174041 |
53 | ATP synthesis coupled proton transport (GO:0015986) | 3.00240121 |
54 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.00240121 |
55 | respiratory electron transport chain (GO:0022904) | 3.00066758 |
56 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.99443966 |
57 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.99242763 |
58 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.98097442 |
59 | aldehyde catabolic process (GO:0046185) | 2.97165587 |
60 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.95953676 |
61 | pseudouridine synthesis (GO:0001522) | 2.95470860 |
62 | respiratory chain complex IV assembly (GO:0008535) | 2.94451155 |
63 | regulation of somitogenesis (GO:0014807) | 2.92303649 |
64 | negative regulation of meiosis (GO:0045835) | 2.91832862 |
65 | nucleotide transmembrane transport (GO:1901679) | 2.90276470 |
66 | vitamin biosynthetic process (GO:0009110) | 2.90244424 |
67 | urate metabolic process (GO:0046415) | 2.90040940 |
68 | cytochrome complex assembly (GO:0017004) | 2.88603902 |
69 | positive regulation of muscle cell apoptotic process (GO:0010661) | 2.87706553 |
70 | behavioral response to nicotine (GO:0035095) | 2.87268082 |
71 | protein import into peroxisome matrix (GO:0016558) | 2.86118285 |
72 | sequestering of actin monomers (GO:0042989) | 2.84969185 |
73 | ubiquinone metabolic process (GO:0006743) | 2.84565460 |
74 | negative regulation of ERK1 and ERK2 cascade (GO:0070373) | 2.81801906 |
75 | DNA ligation (GO:0006266) | 2.80300955 |
76 | reproduction (GO:0000003) | 2.80247877 |
77 | intracellular protein transmembrane import (GO:0044743) | 2.79638750 |
78 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.77142981 |
79 | termination of RNA polymerase III transcription (GO:0006386) | 2.77142981 |
80 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.76977137 |
81 | regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768) | 2.73132158 |
82 | cellular response to interferon-beta (GO:0035458) | 2.71176099 |
83 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.71011674 |
84 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.68824394 |
85 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.68824394 |
86 | positive regulation of interleukin-8 secretion (GO:2000484) | 2.68187082 |
87 | negative regulation of ligase activity (GO:0051352) | 2.67928304 |
88 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.67928304 |
89 | regulation of sodium ion transmembrane transporter activity (GO:2000649) | 2.67411746 |
90 | regulation of interleukin-1 beta production (GO:0032651) | 2.67268480 |
91 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.64877550 |
92 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.64877550 |
93 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.64877550 |
94 | quinone biosynthetic process (GO:1901663) | 2.64861439 |
95 | DNA replication initiation (GO:0006270) | 2.64039538 |
96 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.63795444 |
97 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.63394133 |
98 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.63000850 |
99 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.63000850 |
100 | decidualization (GO:0046697) | 2.62994890 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 6.18978610 |
2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.85601311 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.91660913 |
4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.83100844 |
5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.60248171 |
6 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.59613673 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.03135749 |
8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.92790200 |
9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.55826453 |
10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.52454314 |
11 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.49312292 |
12 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.29221616 |
13 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.19249945 |
14 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.18904476 |
15 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.13643076 |
16 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.13559793 |
17 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.07129150 |
18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.05432825 |
19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.04476464 |
20 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.03593150 |
21 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.99536625 |
22 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.94968672 |
23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91125335 |
24 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.89968528 |
25 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.82524953 |
26 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.79498620 |
27 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.78973297 |
28 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.71163487 |
29 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.70464602 |
30 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.62433742 |
31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.60298766 |
32 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.59090414 |
33 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.58396155 |
34 | GATA3_26560356_Chip-Seq_TH2_Human | 1.56212962 |
35 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.54564769 |
36 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.50541899 |
37 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.45171986 |
38 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.44764108 |
39 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.44335281 |
40 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.43352032 |
41 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.40107237 |
42 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.39840631 |
43 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.37564648 |
44 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.36883198 |
45 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.30700584 |
46 | P300_19829295_ChIP-Seq_ESCs_Human | 1.28998371 |
47 | EWS_26573619_Chip-Seq_HEK293_Human | 1.28746591 |
48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.28398400 |
49 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.27989167 |
50 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24774921 |
51 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.22863043 |
52 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.22066393 |
53 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.20326741 |
54 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.19587805 |
55 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.19123182 |
56 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.14846981 |
57 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.14094791 |
58 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.09303174 |
59 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.09173668 |
60 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.08890779 |
61 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.08237251 |
62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07933992 |
63 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.07866182 |
64 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.07591624 |
65 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.06121873 |
66 | NCOR_22424771_ChIP-Seq_293T_Human | 1.06079838 |
67 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.01267105 |
68 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.01171340 |
69 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.99212062 |
70 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.98041838 |
71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.97086184 |
72 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96460522 |
73 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.94623464 |
74 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.94424189 |
75 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.94372660 |
76 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.93928228 |
77 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.92797619 |
78 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92295736 |
79 | ERA_21632823_ChIP-Seq_H3396_Human | 0.92206860 |
80 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.91658671 |
81 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.91448966 |
82 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.90004507 |
83 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.85414406 |
84 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.85286948 |
85 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.85286948 |
86 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.84329826 |
87 | FUS_26573619_Chip-Seq_HEK293_Human | 0.84101284 |
88 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.83259530 |
89 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.80635489 |
90 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.80127712 |
91 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.79963764 |
92 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.79140589 |
93 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.78610085 |
94 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.76105333 |
95 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.76069496 |
96 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.75950431 |
97 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.75071786 |
98 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.74016406 |
99 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.73746667 |
100 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.73344193 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001529_abnormal_vocalization | 3.43756177 |
2 | MP0002736_abnormal_nociception_after | 3.15613246 |
3 | MP0002653_abnormal_ependyma_morphology | 3.05713015 |
4 | MP0003868_abnormal_feces_composition | 3.04097134 |
5 | MP0008872_abnormal_physiological_respon | 2.98596624 |
6 | MP0005220_abnormal_exocrine_pancreas | 2.91035063 |
7 | MP0003866_abnormal_defecation | 2.83308159 |
8 | MP0005084_abnormal_gallbladder_morpholo | 2.66367034 |
9 | MP0005499_abnormal_olfactory_system | 2.40646636 |
10 | MP0005394_taste/olfaction_phenotype | 2.40646636 |
11 | MP0001919_abnormal_reproductive_system | 2.40268312 |
12 | MP0008877_abnormal_DNA_methylation | 2.39638390 |
13 | MP0003646_muscle_fatigue | 2.35843059 |
14 | MP0003303_peritoneal_inflammation | 2.33078844 |
15 | MP0001984_abnormal_olfaction | 2.32368832 |
16 | MP0001666_abnormal_nutrient_absorption | 2.31892630 |
17 | MP0001968_abnormal_touch/_nociception | 2.25596826 |
18 | MP0005167_abnormal_blood-brain_barrier | 2.21157271 |
19 | MP0003693_abnormal_embryo_hatching | 2.16755488 |
20 | MP0001905_abnormal_dopamine_level | 2.07587832 |
21 | MP0004924_abnormal_behavior | 2.02175981 |
22 | MP0005386_behavior/neurological_phenoty | 2.02175981 |
23 | MP0009278_abnormal_bone_marrow | 2.00347515 |
24 | MP0005671_abnormal_response_to | 1.96239404 |
25 | MP0002928_abnormal_bile_duct | 1.84684840 |
26 | MP0005389_reproductive_system_phenotype | 1.74476251 |
27 | MP0002160_abnormal_reproductive_system | 1.74212896 |
28 | MP0001486_abnormal_startle_reflex | 1.72070435 |
29 | MP0004145_abnormal_muscle_electrophysio | 1.71214973 |
30 | MP0003195_calcinosis | 1.65565699 |
31 | MP0003119_abnormal_digestive_system | 1.62570156 |
32 | MP0002837_dystrophic_cardiac_calcinosis | 1.52200424 |
33 | MP0003959_abnormal_lean_body | 1.51980581 |
34 | MP0001664_abnormal_digestion | 1.49665978 |
35 | MP0003172_abnormal_lysosome_physiology | 1.43302627 |
36 | MP0009046_muscle_twitch | 1.42389409 |
37 | MP0001663_abnormal_digestive_system | 1.40048837 |
38 | MP0006036_abnormal_mitochondrial_physio | 1.38260278 |
39 | MP0002876_abnormal_thyroid_physiology | 1.37387143 |
40 | MP0003045_fibrosis | 1.34823197 |
41 | MP0003786_premature_aging | 1.27831355 |
42 | MP0003111_abnormal_nucleus_morphology | 1.27334899 |
43 | MP0001501_abnormal_sleep_pattern | 1.26388182 |
44 | MP0010329_abnormal_lipoprotein_level | 1.23773536 |
45 | MP0006082_CNS_inflammation | 1.19975858 |
46 | MP0002272_abnormal_nervous_system | 1.19790780 |
47 | MP0002067_abnormal_sensory_capabilities | 1.14835808 |
48 | MP0002234_abnormal_pharynx_morphology | 1.12347921 |
49 | MP0005083_abnormal_biliary_tract | 1.11939686 |
50 | MP0008875_abnormal_xenobiotic_pharmacok | 1.10687954 |
51 | MP0003567_abnormal_fetal_cardiomyocyte | 1.10262978 |
52 | MP0009745_abnormal_behavioral_response | 1.05590957 |
53 | MP0002102_abnormal_ear_morphology | 1.04998894 |
54 | MP0009785_altered_susceptibility_to | 1.03686707 |
55 | MP0002693_abnormal_pancreas_physiology | 1.03561568 |
56 | MP0010094_abnormal_chromosome_stability | 1.02053999 |
57 | MP0003448_altered_tumor_morphology | 1.01796044 |
58 | MP0008007_abnormal_cellular_replicative | 1.00973503 |
59 | MP0003638_abnormal_response/metabolism_ | 0.99606991 |
60 | MP0004147_increased_porphyrin_level | 0.98058391 |
61 | MP0002063_abnormal_learning/memory/cond | 0.96508172 |
62 | MP0001502_abnormal_circadian_rhythm | 0.95312345 |
63 | MP0001270_distended_abdomen | 0.93144527 |
64 | MP0000538_abnormal_urinary_bladder | 0.91129411 |
65 | MP0006035_abnormal_mitochondrial_morpho | 0.90341605 |
66 | MP0009840_abnormal_foam_cell | 0.89684676 |
67 | MP0003880_abnormal_central_pattern | 0.87757173 |
68 | MP0009697_abnormal_copulation | 0.86978508 |
69 | MP0005448_abnormal_energy_balance | 0.86880156 |
70 | MP0002557_abnormal_social/conspecific_i | 0.86726990 |
71 | MP0000470_abnormal_stomach_morphology | 0.84301073 |
72 | MP0010030_abnormal_orbit_morphology | 0.83553719 |
73 | MP0002095_abnormal_skin_pigmentation | 0.82949393 |
74 | MP0001986_abnormal_taste_sensitivity | 0.81260109 |
75 | MP0000631_abnormal_neuroendocrine_gland | 0.80529521 |
76 | MP0002210_abnormal_sex_determination | 0.80339196 |
77 | MP0000343_altered_response_to | 0.79708107 |
78 | MP0006292_abnormal_olfactory_placode | 0.79491763 |
79 | MP0009672_abnormal_birth_weight | 0.78869051 |
80 | MP0003077_abnormal_cell_cycle | 0.78531177 |
81 | MP0005381_digestive/alimentary_phenotyp | 0.77997804 |
82 | MP0001929_abnormal_gametogenesis | 0.77320514 |
83 | MP0004133_heterotaxia | 0.76444193 |
84 | MP0010155_abnormal_intestine_physiology | 0.76029189 |
85 | MP0004130_abnormal_muscle_cell | 0.74737413 |
86 | MP0002572_abnormal_emotion/affect_behav | 0.73751156 |
87 | MP0002006_tumorigenesis | 0.72195328 |
88 | MP0003137_abnormal_impulse_conducting | 0.71826505 |
89 | MP0009643_abnormal_urine_homeostasis | 0.71749298 |
90 | MP0003698_abnormal_male_reproductive | 0.70337258 |
91 | MP0002734_abnormal_mechanical_nocicepti | 0.70254941 |
92 | MP0005623_abnormal_meninges_morphology | 0.70020133 |
93 | MP0005397_hematopoietic_system_phenotyp | 0.68800951 |
94 | MP0001545_abnormal_hematopoietic_system | 0.68800951 |
95 | MP0005647_abnormal_sex_gland | 0.68598338 |
96 | MP0002733_abnormal_thermal_nociception | 0.67935532 |
97 | MP0001119_abnormal_female_reproductive | 0.67242089 |
98 | MP0005551_abnormal_eye_electrophysiolog | 0.66893698 |
99 | MP0001835_abnormal_antigen_presentation | 0.66397359 |
100 | MP0003283_abnormal_digestive_organ | 0.64800410 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Birth length less than 3rd percentile (HP:0003561) | 6.17389993 |
2 | Type II lissencephaly (HP:0007260) | 5.47095180 |
3 | Global brain atrophy (HP:0002283) | 4.58414279 |
4 | Abnormality of alanine metabolism (HP:0010916) | 4.40858043 |
5 | Hyperalaninemia (HP:0003348) | 4.40858043 |
6 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 4.40858043 |
7 | Breast hypoplasia (HP:0003187) | 4.22710272 |
8 | Metaphyseal dysplasia (HP:0100255) | 4.07654877 |
9 | Cerebellar dysplasia (HP:0007033) | 4.02253608 |
10 | Hypoplastic labia majora (HP:0000059) | 3.65010320 |
11 | Generalized aminoaciduria (HP:0002909) | 3.43794636 |
12 | Abnormality of the labia majora (HP:0012881) | 3.30369346 |
13 | Retinal dysplasia (HP:0007973) | 3.27487714 |
14 | Gastrointestinal infarctions (HP:0005244) | 3.22743524 |
15 | Rectal prolapse (HP:0002035) | 3.11041824 |
16 | Nasal polyposis (HP:0100582) | 2.95511067 |
17 | Methylmalonic acidemia (HP:0002912) | 2.91463696 |
18 | Pancreatic fibrosis (HP:0100732) | 2.91037765 |
19 | Hepatic necrosis (HP:0002605) | 2.90437784 |
20 | Abnormality of the fingertips (HP:0001211) | 2.85016458 |
21 | Neoplasm of head and neck (HP:0012288) | 2.73168786 |
22 | Esophageal neoplasm (HP:0100751) | 2.73168786 |
23 | Abnormality of the nasal mucosa (HP:0000433) | 2.72700548 |
24 | Hyperglycinemia (HP:0002154) | 2.72493192 |
25 | Chorioretinal atrophy (HP:0000533) | 2.71011680 |
26 | Hypoplastic female external genitalia (HP:0012815) | 2.68038295 |
27 | Absent speech (HP:0001344) | 2.67606919 |
28 | Progressive inability to walk (HP:0002505) | 2.61636943 |
29 | Prominent supraorbital ridges (HP:0000336) | 2.56344252 |
30 | Hepatocellular necrosis (HP:0001404) | 2.50699280 |
31 | Hypoproteinemia (HP:0003075) | 2.49131507 |
32 | Ulnar claw (HP:0001178) | 2.43890133 |
33 | Labial hypoplasia (HP:0000066) | 2.43677614 |
34 | Patellar aplasia (HP:0006443) | 2.43164848 |
35 | Acute necrotizing encephalopathy (HP:0006965) | 2.41335045 |
36 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.38433064 |
37 | Female pseudohermaphroditism (HP:0010458) | 2.38102153 |
38 | Disproportionate short-trunk short stature (HP:0003521) | 2.37456512 |
39 | Clumsiness (HP:0002312) | 2.36748174 |
40 | Pancreatic cysts (HP:0001737) | 2.36516855 |
41 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.31990715 |
42 | Pancytopenia (HP:0001876) | 2.31108893 |
43 | Mitochondrial inheritance (HP:0001427) | 2.29670783 |
44 | Inability to walk (HP:0002540) | 2.28213295 |
45 | Partial agenesis of the corpus callosum (HP:0001338) | 2.25337672 |
46 | Pendular nystagmus (HP:0012043) | 2.24812555 |
47 | Bile duct proliferation (HP:0001408) | 2.24395628 |
48 | Abnormal biliary tract physiology (HP:0012439) | 2.24395628 |
49 | Encephalitis (HP:0002383) | 2.24082564 |
50 | CNS demyelination (HP:0007305) | 2.23207123 |
51 | Gonadal dysgenesis (HP:0000133) | 2.22921795 |
52 | Broad-based gait (HP:0002136) | 2.22389672 |
53 | Lissencephaly (HP:0001339) | 2.21194868 |
54 | Optic nerve hypoplasia (HP:0000609) | 2.20635976 |
55 | Congenital stationary night blindness (HP:0007642) | 2.19420949 |
56 | Acute encephalopathy (HP:0006846) | 2.19324709 |
57 | Severe combined immunodeficiency (HP:0004430) | 2.16302799 |
58 | Nephronophthisis (HP:0000090) | 2.14655997 |
59 | Ketosis (HP:0001946) | 2.12934860 |
60 | Neonatal onset (HP:0003623) | 2.11785033 |
61 | 3-Methylglutaconic aciduria (HP:0003535) | 2.11388469 |
62 | Abolished electroretinogram (ERG) (HP:0000550) | 2.11163636 |
63 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.08004675 |
64 | Absent/shortened dynein arms (HP:0200106) | 2.08004675 |
65 | Abnormal ciliary motility (HP:0012262) | 2.07863268 |
66 | Progressive microcephaly (HP:0000253) | 2.07672978 |
67 | Methylmalonic aciduria (HP:0012120) | 2.07028457 |
68 | Abnormality of serum amino acid levels (HP:0003112) | 2.06370870 |
69 | Pachygyria (HP:0001302) | 2.03494658 |
70 | Optic disc pallor (HP:0000543) | 2.03166816 |
71 | Abnormality of urine glucose concentration (HP:0011016) | 2.02989055 |
72 | Glycosuria (HP:0003076) | 2.02989055 |
73 | T lymphocytopenia (HP:0005403) | 2.02734761 |
74 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.02668890 |
75 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.02668890 |
76 | Abnormality of the renal cortex (HP:0011035) | 2.01107315 |
77 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.00306066 |
78 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.00251027 |
79 | Increased hepatocellular lipid droplets (HP:0006565) | 1.99245845 |
80 | Renal cortical cysts (HP:0000803) | 1.99169791 |
81 | Microretrognathia (HP:0000308) | 1.96752090 |
82 | Short tibia (HP:0005736) | 1.96409066 |
83 | Hyperventilation (HP:0002883) | 1.95884160 |
84 | Progressive macrocephaly (HP:0004481) | 1.95756193 |
85 | Abnormality of the labia minora (HP:0012880) | 1.94621939 |
86 | True hermaphroditism (HP:0010459) | 1.94614417 |
87 | Increased CSF lactate (HP:0002490) | 1.92637526 |
88 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.92452929 |
89 | Abnormality of lateral ventricle (HP:0030047) | 1.91816903 |
90 | Duplicated collecting system (HP:0000081) | 1.90554698 |
91 | Brushfield spots (HP:0001088) | 1.89475558 |
92 | Tubular atrophy (HP:0000092) | 1.89397533 |
93 | Abnormality of nail color (HP:0100643) | 1.88512532 |
94 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.88363538 |
95 | Dicarboxylic aciduria (HP:0003215) | 1.88363538 |
96 | Biliary tract neoplasm (HP:0100574) | 1.86620873 |
97 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.86284437 |
98 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.84227580 |
99 | Mesangial abnormality (HP:0001966) | 1.83112667 |
100 | Renal Fanconi syndrome (HP:0001994) | 1.82297486 |
Rank | Gene Set | Z-score |
---|---|---|
1 | INSRR | 7.45087554 |
2 | BCKDK | 4.10658549 |
3 | GRK1 | 3.62288418 |
4 | KDR | 3.49755920 |
5 | VRK2 | 3.48345230 |
6 | TIE1 | 3.14848759 |
7 | ADRBK2 | 2.56588242 |
8 | TESK2 | 2.48449248 |
9 | LIMK1 | 2.30094377 |
10 | MAP2K7 | 2.22054833 |
11 | MAP3K11 | 2.20561562 |
12 | BRSK2 | 2.11357916 |
13 | WEE1 | 1.86598496 |
14 | CDK8 | 1.82530710 |
15 | BUB1 | 1.81184018 |
16 | ITK | 1.77353768 |
17 | TLK1 | 1.76842532 |
18 | VRK1 | 1.60822162 |
19 | TESK1 | 1.56389302 |
20 | CAMKK2 | 1.42738960 |
21 | RPS6KA5 | 1.36662267 |
22 | TAOK3 | 1.33016290 |
23 | WNK3 | 1.28860468 |
24 | MAPKAPK3 | 1.28472086 |
25 | FRK | 1.26485295 |
26 | CDC7 | 1.21854755 |
27 | MAP3K4 | 1.21786688 |
28 | WNK4 | 1.08492722 |
29 | FER | 1.07375170 |
30 | NUAK1 | 1.06649380 |
31 | DYRK2 | 1.01138017 |
32 | MARK1 | 1.00077105 |
33 | TXK | 0.95113288 |
34 | ABL2 | 0.93436928 |
35 | PKN1 | 0.91284828 |
36 | CDK19 | 0.90702644 |
37 | TEC | 0.87765900 |
38 | CASK | 0.86782826 |
39 | BRSK1 | 0.86467615 |
40 | OXSR1 | 0.80998254 |
41 | BMPR1B | 0.76901460 |
42 | STK16 | 0.76494912 |
43 | GRK5 | 0.75839992 |
44 | PDK2 | 0.69842448 |
45 | TAF1 | 0.69486631 |
46 | TGFBR1 | 0.67171673 |
47 | PRKCQ | 0.66891582 |
48 | MAPK13 | 0.64838792 |
49 | RPS6KA2 | 0.61743702 |
50 | MUSK | 0.61261065 |
51 | MAP4K1 | 0.60365875 |
52 | MAPKAPK5 | 0.59769050 |
53 | STK39 | 0.59618635 |
54 | PLK1 | 0.58628294 |
55 | DAPK1 | 0.58205270 |
56 | PLK3 | 0.57331570 |
57 | STK11 | 0.56047458 |
58 | ZAK | 0.55215589 |
59 | PINK1 | 0.54936551 |
60 | RPS6KA6 | 0.54829549 |
61 | MAP4K2 | 0.53671966 |
62 | AURKB | 0.53646098 |
63 | CDK9 | 0.52581644 |
64 | AURKA | 0.49934731 |
65 | CCNB1 | 0.49330917 |
66 | PLK4 | 0.48033214 |
67 | NEK1 | 0.47297772 |
68 | ATR | 0.45234138 |
69 | LCK | 0.44766215 |
70 | SYK | 0.44091720 |
71 | ACVR1B | 0.41556157 |
72 | CSNK2A1 | 0.38849179 |
73 | CSNK1G3 | 0.38611086 |
74 | CAMK2D | 0.38284331 |
75 | CAMK2A | 0.36544718 |
76 | EIF2AK2 | 0.36173898 |
77 | ADRBK1 | 0.35612196 |
78 | TNK2 | 0.33999289 |
79 | PRKCE | 0.33975707 |
80 | GRK7 | 0.33724876 |
81 | RPS6KB1 | 0.33419834 |
82 | IRAK1 | 0.33026716 |
83 | PRKCA | 0.32501601 |
84 | PRKCZ | 0.31889756 |
85 | FES | 0.31445656 |
86 | ATM | 0.31376405 |
87 | IKBKB | 0.30809035 |
88 | CSNK1A1L | 0.30381024 |
89 | PRKACA | 0.30342181 |
90 | CAMK2G | 0.28130289 |
91 | CHEK2 | 0.26616155 |
92 | LYN | 0.26613437 |
93 | CAMK1D | 0.26563939 |
94 | IRAK4 | 0.26474567 |
95 | CDK7 | 0.25658709 |
96 | NME1 | 0.23859139 |
97 | OBSCN | 0.23474266 |
98 | RPS6KC1 | 0.22725419 |
99 | RPS6KL1 | 0.22725419 |
100 | DAPK3 | 0.22279421 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.44463950 |
2 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 3.67466633 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.65882150 |
4 | Protein export_Homo sapiens_hsa03060 | 3.50777109 |
5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.12977428 |
6 | Butanoate metabolism_Homo sapiens_hsa00650 | 3.10252833 |
7 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.65124788 |
8 | Homologous recombination_Homo sapiens_hsa03440 | 2.59055461 |
9 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.29646961 |
10 | Basal transcription factors_Homo sapiens_hsa03022 | 2.20678881 |
11 | RNA polymerase_Homo sapiens_hsa03020 | 2.15344378 |
12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.11400209 |
13 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.91314431 |
14 | DNA replication_Homo sapiens_hsa03030 | 1.86104877 |
15 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.81904340 |
16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.81174173 |
17 | Mismatch repair_Homo sapiens_hsa03430 | 1.73236640 |
18 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.70393035 |
19 | Phototransduction_Homo sapiens_hsa04744 | 1.67445240 |
20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.66932006 |
21 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.65888990 |
22 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.64403473 |
23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.58923140 |
24 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.57270337 |
25 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.54972607 |
26 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.52614385 |
27 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.52304930 |
28 | Ribosome_Homo sapiens_hsa03010 | 1.49976133 |
29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.48158835 |
30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.42852492 |
31 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.42030798 |
32 | Sulfur relay system_Homo sapiens_hsa04122 | 1.40792558 |
33 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.33743814 |
34 | Allograft rejection_Homo sapiens_hsa05330 | 1.33659054 |
35 | Nicotine addiction_Homo sapiens_hsa05033 | 1.26303034 |
36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.25599547 |
37 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.22428950 |
38 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.20577281 |
39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.16192677 |
40 | Taste transduction_Homo sapiens_hsa04742 | 1.14855276 |
41 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.12022657 |
42 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.07979204 |
43 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.01775767 |
44 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.92946327 |
45 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.92603341 |
46 | Purine metabolism_Homo sapiens_hsa00230 | 0.91110096 |
47 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.86962063 |
48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.83795078 |
49 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.75725658 |
50 | Spliceosome_Homo sapiens_hsa03040 | 0.74106276 |
51 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.74077077 |
52 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.74011802 |
53 | Peroxisome_Homo sapiens_hsa04146 | 0.71427452 |
54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.70281503 |
55 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.67561312 |
56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.66938205 |
57 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.65697007 |
58 | Cell cycle_Homo sapiens_hsa04110 | 0.65549592 |
59 | RNA degradation_Homo sapiens_hsa03018 | 0.65414221 |
60 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.65180913 |
61 | Base excision repair_Homo sapiens_hsa03410 | 0.64704670 |
62 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.63265560 |
63 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.63256799 |
64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60270089 |
65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.58126210 |
66 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.57902528 |
67 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.55860953 |
68 | Shigellosis_Homo sapiens_hsa05131 | 0.55530404 |
69 | Lysosome_Homo sapiens_hsa04142 | 0.47987395 |
70 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.45928459 |
71 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.43924817 |
72 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.43551806 |
73 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.42944281 |
74 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.41597642 |
75 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.38264110 |
76 | Olfactory transduction_Homo sapiens_hsa04740 | 0.36687857 |
77 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.35786649 |
78 | Asthma_Homo sapiens_hsa05310 | 0.33423051 |
79 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.32710298 |
80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32270489 |
81 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.31852822 |
82 | Viral myocarditis_Homo sapiens_hsa05416 | 0.30845287 |
83 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.29038264 |
84 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.27875112 |
85 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.25617480 |
86 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.24890764 |
87 | RNA transport_Homo sapiens_hsa03013 | 0.24428164 |
88 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.23521090 |
89 | Morphine addiction_Homo sapiens_hsa05032 | 0.21592271 |
90 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.21011390 |
91 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.20476295 |
92 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.20439452 |
93 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.19073530 |
94 | Measles_Homo sapiens_hsa05162 | 0.17616893 |
95 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.16792948 |
96 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.16311584 |
97 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.14831285 |
98 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.12575816 |
99 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.12517524 |
100 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.12224317 |