HMGN2P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of sodium ion transmembrane transporter activity (GO:2000651)7.79729631
2growth hormone secretion (GO:0030252)7.51281283
3regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)7.27435535
4negative regulation of interleukin-1 beta production (GO:0032691)7.19323007
5adult feeding behavior (GO:0008343)6.82328334
6positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)6.30470713
7water-soluble vitamin biosynthetic process (GO:0042364)6.01619398
8negative regulation of interleukin-1 production (GO:0032692)5.92890194
9DNA deamination (GO:0045006)5.82194663
10positive regulation of sodium ion transmembrane transport (GO:1902307)5.44154662
11regulation of response to food (GO:0032095)5.41411231
12adaptation of signaling pathway (GO:0023058)5.20414781
13cytidine deamination (GO:0009972)5.19649277
14cytidine metabolic process (GO:0046087)5.19649277
15cytidine catabolic process (GO:0006216)5.19649277
16regulation of tumor necrosis factor biosynthetic process (GO:0042534)5.16301335
17regulation of appetite (GO:0032098)4.85791857
18positive thymic T cell selection (GO:0045059)4.74312678
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69144884
20hindbrain development (GO:0030902)4.58807262
21regulation of interleukin-6 biosynthetic process (GO:0045408)4.41318863
22response to food (GO:0032094)4.37399631
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.34467501
24multicellular organism reproduction (GO:0032504)4.32064876
25negative regulation of T cell differentiation in thymus (GO:0033085)3.88554473
26cytolysis (GO:0019835)3.84360573
27positive regulation of gluconeogenesis (GO:0045722)3.82943706
28one-carbon compound transport (GO:0019755)3.74371178
29negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.73740926
30regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.72563126
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.65023812
32piRNA metabolic process (GO:0034587)3.63868434
33protein K6-linked ubiquitination (GO:0085020)3.48211160
34positive regulation of defense response to virus by host (GO:0002230)3.46470772
35regulation of mitochondrial membrane permeability (GO:0046902)3.43193786
36ubiquinone biosynthetic process (GO:0006744)3.39113449
37proteasome assembly (GO:0043248)3.39013185
38regulation of membrane permeability (GO:0090559)3.27805115
39sperm capacitation (GO:0048240)3.25562478
40negative regulation of mast cell activation (GO:0033004)3.24136631
41T cell migration (GO:0072678)3.23055044
42microtubule depolymerization (GO:0007019)3.21888571
43positive T cell selection (GO:0043368)3.19432092
44protein kinase B signaling (GO:0043491)3.18988632
45GMP metabolic process (GO:0046037)3.18128920
46electron transport chain (GO:0022900)3.10449793
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10317709
48chaperone-mediated protein transport (GO:0072321)3.07961624
49auditory receptor cell stereocilium organization (GO:0060088)3.06689092
50regulation of cellular amino acid metabolic process (GO:0006521)3.06467054
51DNA demethylation (GO:0080111)3.04243630
52thymic T cell selection (GO:0045061)3.01174041
53ATP synthesis coupled proton transport (GO:0015986)3.00240121
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00240121
55respiratory electron transport chain (GO:0022904)3.00066758
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99443966
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99242763
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98097442
59aldehyde catabolic process (GO:0046185)2.97165587
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95953676
61pseudouridine synthesis (GO:0001522)2.95470860
62respiratory chain complex IV assembly (GO:0008535)2.94451155
63regulation of somitogenesis (GO:0014807)2.92303649
64negative regulation of meiosis (GO:0045835)2.91832862
65nucleotide transmembrane transport (GO:1901679)2.90276470
66vitamin biosynthetic process (GO:0009110)2.90244424
67urate metabolic process (GO:0046415)2.90040940
68cytochrome complex assembly (GO:0017004)2.88603902
69positive regulation of muscle cell apoptotic process (GO:0010661)2.87706553
70behavioral response to nicotine (GO:0035095)2.87268082
71protein import into peroxisome matrix (GO:0016558)2.86118285
72sequestering of actin monomers (GO:0042989)2.84969185
73ubiquinone metabolic process (GO:0006743)2.84565460
74negative regulation of ERK1 and ERK2 cascade (GO:0070373)2.81801906
75DNA ligation (GO:0006266)2.80300955
76reproduction (GO:0000003)2.80247877
77intracellular protein transmembrane import (GO:0044743)2.79638750
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.77142981
79termination of RNA polymerase III transcription (GO:0006386)2.77142981
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76977137
81regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.73132158
82cellular response to interferon-beta (GO:0035458)2.71176099
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71011674
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68824394
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68824394
86positive regulation of interleukin-8 secretion (GO:2000484)2.68187082
87negative regulation of ligase activity (GO:0051352)2.67928304
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67928304
89regulation of sodium ion transmembrane transporter activity (GO:2000649)2.67411746
90regulation of interleukin-1 beta production (GO:0032651)2.67268480
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64877550
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64877550
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64877550
94quinone biosynthetic process (GO:1901663)2.64861439
95DNA replication initiation (GO:0006270)2.64039538
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63795444
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63394133
98ATP hydrolysis coupled proton transport (GO:0015991)2.63000850
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.63000850
100decidualization (GO:0046697)2.62994890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human6.18978610
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.85601311
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91660913
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83100844
5ZNF274_21170338_ChIP-Seq_K562_Hela3.60248171
6EZH2_22144423_ChIP-Seq_EOC_Human3.59613673
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.03135749
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92790200
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55826453
10VDR_22108803_ChIP-Seq_LS180_Human2.52454314
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.49312292
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29221616
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19249945
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.18904476
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13643076
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13559793
17GBX2_23144817_ChIP-Seq_PC3_Human2.07129150
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05432825
19VDR_23849224_ChIP-Seq_CD4+_Human2.04476464
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03593150
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.99536625
22IRF1_19129219_ChIP-ChIP_H3396_Human1.94968672
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.91125335
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89968528
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82524953
26AR_21572438_ChIP-Seq_LNCaP_Human1.79498620
27E2F7_22180533_ChIP-Seq_HELA_Human1.78973297
28IGF1R_20145208_ChIP-Seq_DFB_Human1.71163487
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70464602
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62433742
31FOXP3_21729870_ChIP-Seq_TREG_Human1.60298766
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59090414
33HTT_18923047_ChIP-ChIP_STHdh_Human1.58396155
34GATA3_26560356_Chip-Seq_TH2_Human1.56212962
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54564769
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50541899
37TP53_22573176_ChIP-Seq_HFKS_Human1.45171986
38CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.44764108
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44335281
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43352032
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40107237
42TAF2_19829295_ChIP-Seq_ESCs_Human1.39840631
43MYC_18940864_ChIP-ChIP_HL60_Human1.37564648
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36883198
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30700584
46P300_19829295_ChIP-Seq_ESCs_Human1.28998371
47EWS_26573619_Chip-Seq_HEK293_Human1.28746591
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.28398400
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27989167
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24774921
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22863043
52ER_23166858_ChIP-Seq_MCF-7_Human1.22066393
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20326741
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19587805
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19123182
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14846981
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14094791
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09303174
59GABP_19822575_ChIP-Seq_HepG2_Human1.09173668
60MYC_19829295_ChIP-Seq_ESCs_Human1.08890779
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08237251
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07933992
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07866182
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07591624
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.06121873
66NCOR_22424771_ChIP-Seq_293T_Human1.06079838
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.01267105
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01171340
69P53_21459846_ChIP-Seq_SAOS-2_Human0.99212062
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98041838
71FLI1_27457419_Chip-Seq_LIVER_Mouse0.97086184
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.96460522
73IRF8_21731497_ChIP-ChIP_J774_Mouse0.94623464
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94424189
75TTF2_22483619_ChIP-Seq_HELA_Human0.94372660
76ELK1_19687146_ChIP-ChIP_HELA_Human0.93928228
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92797619
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92295736
79ERA_21632823_ChIP-Seq_H3396_Human0.92206860
80DCP1A_22483619_ChIP-Seq_HELA_Human0.91658671
81HOXB7_26014856_ChIP-Seq_BT474_Human0.91448966
82CTCF_20526341_ChIP-Seq_ESCs_Human0.90004507
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85414406
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.85286948
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85286948
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84329826
87FUS_26573619_Chip-Seq_HEK293_Human0.84101284
88RAC3_21632823_ChIP-Seq_H3396_Human0.83259530
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80635489
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80127712
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79963764
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.79140589
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.78610085
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.76105333
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76069496
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75950431
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75071786
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.74016406
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73746667
100NANOG_19829295_ChIP-Seq_ESCs_Human0.73344193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.43756177
2MP0002736_abnormal_nociception_after3.15613246
3MP0002653_abnormal_ependyma_morphology3.05713015
4MP0003868_abnormal_feces_composition3.04097134
5MP0008872_abnormal_physiological_respon2.98596624
6MP0005220_abnormal_exocrine_pancreas2.91035063
7MP0003866_abnormal_defecation2.83308159
8MP0005084_abnormal_gallbladder_morpholo2.66367034
9MP0005499_abnormal_olfactory_system2.40646636
10MP0005394_taste/olfaction_phenotype2.40646636
11MP0001919_abnormal_reproductive_system2.40268312
12MP0008877_abnormal_DNA_methylation2.39638390
13MP0003646_muscle_fatigue2.35843059
14MP0003303_peritoneal_inflammation2.33078844
15MP0001984_abnormal_olfaction2.32368832
16MP0001666_abnormal_nutrient_absorption2.31892630
17MP0001968_abnormal_touch/_nociception2.25596826
18MP0005167_abnormal_blood-brain_barrier2.21157271
19MP0003693_abnormal_embryo_hatching2.16755488
20MP0001905_abnormal_dopamine_level2.07587832
21MP0004924_abnormal_behavior2.02175981
22MP0005386_behavior/neurological_phenoty2.02175981
23MP0009278_abnormal_bone_marrow2.00347515
24MP0005671_abnormal_response_to1.96239404
25MP0002928_abnormal_bile_duct1.84684840
26MP0005389_reproductive_system_phenotype1.74476251
27MP0002160_abnormal_reproductive_system1.74212896
28MP0001486_abnormal_startle_reflex1.72070435
29MP0004145_abnormal_muscle_electrophysio1.71214973
30MP0003195_calcinosis1.65565699
31MP0003119_abnormal_digestive_system1.62570156
32MP0002837_dystrophic_cardiac_calcinosis1.52200424
33MP0003959_abnormal_lean_body1.51980581
34MP0001664_abnormal_digestion1.49665978
35MP0003172_abnormal_lysosome_physiology1.43302627
36MP0009046_muscle_twitch1.42389409
37MP0001663_abnormal_digestive_system1.40048837
38MP0006036_abnormal_mitochondrial_physio1.38260278
39MP0002876_abnormal_thyroid_physiology1.37387143
40MP0003045_fibrosis1.34823197
41MP0003786_premature_aging1.27831355
42MP0003111_abnormal_nucleus_morphology1.27334899
43MP0001501_abnormal_sleep_pattern1.26388182
44MP0010329_abnormal_lipoprotein_level1.23773536
45MP0006082_CNS_inflammation1.19975858
46MP0002272_abnormal_nervous_system1.19790780
47MP0002067_abnormal_sensory_capabilities1.14835808
48MP0002234_abnormal_pharynx_morphology1.12347921
49MP0005083_abnormal_biliary_tract1.11939686
50MP0008875_abnormal_xenobiotic_pharmacok1.10687954
51MP0003567_abnormal_fetal_cardiomyocyte1.10262978
52MP0009745_abnormal_behavioral_response1.05590957
53MP0002102_abnormal_ear_morphology1.04998894
54MP0009785_altered_susceptibility_to1.03686707
55MP0002693_abnormal_pancreas_physiology1.03561568
56MP0010094_abnormal_chromosome_stability1.02053999
57MP0003448_altered_tumor_morphology1.01796044
58MP0008007_abnormal_cellular_replicative1.00973503
59MP0003638_abnormal_response/metabolism_0.99606991
60MP0004147_increased_porphyrin_level0.98058391
61MP0002063_abnormal_learning/memory/cond0.96508172
62MP0001502_abnormal_circadian_rhythm0.95312345
63MP0001270_distended_abdomen0.93144527
64MP0000538_abnormal_urinary_bladder0.91129411
65MP0006035_abnormal_mitochondrial_morpho0.90341605
66MP0009840_abnormal_foam_cell0.89684676
67MP0003880_abnormal_central_pattern0.87757173
68MP0009697_abnormal_copulation0.86978508
69MP0005448_abnormal_energy_balance0.86880156
70MP0002557_abnormal_social/conspecific_i0.86726990
71MP0000470_abnormal_stomach_morphology0.84301073
72MP0010030_abnormal_orbit_morphology0.83553719
73MP0002095_abnormal_skin_pigmentation0.82949393
74MP0001986_abnormal_taste_sensitivity0.81260109
75MP0000631_abnormal_neuroendocrine_gland0.80529521
76MP0002210_abnormal_sex_determination0.80339196
77MP0000343_altered_response_to0.79708107
78MP0006292_abnormal_olfactory_placode0.79491763
79MP0009672_abnormal_birth_weight0.78869051
80MP0003077_abnormal_cell_cycle0.78531177
81MP0005381_digestive/alimentary_phenotyp0.77997804
82MP0001929_abnormal_gametogenesis0.77320514
83MP0004133_heterotaxia0.76444193
84MP0010155_abnormal_intestine_physiology0.76029189
85MP0004130_abnormal_muscle_cell0.74737413
86MP0002572_abnormal_emotion/affect_behav0.73751156
87MP0002006_tumorigenesis0.72195328
88MP0003137_abnormal_impulse_conducting0.71826505
89MP0009643_abnormal_urine_homeostasis0.71749298
90MP0003698_abnormal_male_reproductive0.70337258
91MP0002734_abnormal_mechanical_nocicepti0.70254941
92MP0005623_abnormal_meninges_morphology0.70020133
93MP0005397_hematopoietic_system_phenotyp0.68800951
94MP0001545_abnormal_hematopoietic_system0.68800951
95MP0005647_abnormal_sex_gland0.68598338
96MP0002733_abnormal_thermal_nociception0.67935532
97MP0001119_abnormal_female_reproductive0.67242089
98MP0005551_abnormal_eye_electrophysiolog0.66893698
99MP0001835_abnormal_antigen_presentation0.66397359
100MP0003283_abnormal_digestive_organ0.64800410

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.17389993
2Type II lissencephaly (HP:0007260)5.47095180
3Global brain atrophy (HP:0002283)4.58414279
4Abnormality of alanine metabolism (HP:0010916)4.40858043
5Hyperalaninemia (HP:0003348)4.40858043
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.40858043
7Breast hypoplasia (HP:0003187)4.22710272
8Metaphyseal dysplasia (HP:0100255)4.07654877
9Cerebellar dysplasia (HP:0007033)4.02253608
10Hypoplastic labia majora (HP:0000059)3.65010320
11Generalized aminoaciduria (HP:0002909)3.43794636
12Abnormality of the labia majora (HP:0012881)3.30369346
13Retinal dysplasia (HP:0007973)3.27487714
14Gastrointestinal infarctions (HP:0005244)3.22743524
15Rectal prolapse (HP:0002035)3.11041824
16Nasal polyposis (HP:0100582)2.95511067
17Methylmalonic acidemia (HP:0002912)2.91463696
18Pancreatic fibrosis (HP:0100732)2.91037765
19Hepatic necrosis (HP:0002605)2.90437784
20Abnormality of the fingertips (HP:0001211)2.85016458
21Neoplasm of head and neck (HP:0012288)2.73168786
22Esophageal neoplasm (HP:0100751)2.73168786
23Abnormality of the nasal mucosa (HP:0000433)2.72700548
24Hyperglycinemia (HP:0002154)2.72493192
25Chorioretinal atrophy (HP:0000533)2.71011680
26Hypoplastic female external genitalia (HP:0012815)2.68038295
27Absent speech (HP:0001344)2.67606919
28Progressive inability to walk (HP:0002505)2.61636943
29Prominent supraorbital ridges (HP:0000336)2.56344252
30Hepatocellular necrosis (HP:0001404)2.50699280
31Hypoproteinemia (HP:0003075)2.49131507
32Ulnar claw (HP:0001178)2.43890133
33Labial hypoplasia (HP:0000066)2.43677614
34Patellar aplasia (HP:0006443)2.43164848
35Acute necrotizing encephalopathy (HP:0006965)2.41335045
36Aplasia/Hypoplasia of the patella (HP:0006498)2.38433064
37Female pseudohermaphroditism (HP:0010458)2.38102153
38Disproportionate short-trunk short stature (HP:0003521)2.37456512
39Clumsiness (HP:0002312)2.36748174
40Pancreatic cysts (HP:0001737)2.36516855
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31990715
42Pancytopenia (HP:0001876)2.31108893
43Mitochondrial inheritance (HP:0001427)2.29670783
44Inability to walk (HP:0002540)2.28213295
45Partial agenesis of the corpus callosum (HP:0001338)2.25337672
46Pendular nystagmus (HP:0012043)2.24812555
47Bile duct proliferation (HP:0001408)2.24395628
48Abnormal biliary tract physiology (HP:0012439)2.24395628
49Encephalitis (HP:0002383)2.24082564
50CNS demyelination (HP:0007305)2.23207123
51Gonadal dysgenesis (HP:0000133)2.22921795
52Broad-based gait (HP:0002136)2.22389672
53Lissencephaly (HP:0001339)2.21194868
54Optic nerve hypoplasia (HP:0000609)2.20635976
55Congenital stationary night blindness (HP:0007642)2.19420949
56Acute encephalopathy (HP:0006846)2.19324709
57Severe combined immunodeficiency (HP:0004430)2.16302799
58Nephronophthisis (HP:0000090)2.14655997
59Ketosis (HP:0001946)2.12934860
60Neonatal onset (HP:0003623)2.11785033
613-Methylglutaconic aciduria (HP:0003535)2.11388469
62Abolished electroretinogram (ERG) (HP:0000550)2.11163636
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.08004675
64Absent/shortened dynein arms (HP:0200106)2.08004675
65Abnormal ciliary motility (HP:0012262)2.07863268
66Progressive microcephaly (HP:0000253)2.07672978
67Methylmalonic aciduria (HP:0012120)2.07028457
68Abnormality of serum amino acid levels (HP:0003112)2.06370870
69Pachygyria (HP:0001302)2.03494658
70Optic disc pallor (HP:0000543)2.03166816
71Abnormality of urine glucose concentration (HP:0011016)2.02989055
72Glycosuria (HP:0003076)2.02989055
73T lymphocytopenia (HP:0005403)2.02734761
74Abnormal respiratory epithelium morphology (HP:0012253)2.02668890
75Abnormal respiratory motile cilium morphology (HP:0005938)2.02668890
76Abnormality of the renal cortex (HP:0011035)2.01107315
77Abnormal mitochondria in muscle tissue (HP:0008316)2.00306066
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00251027
79Increased hepatocellular lipid droplets (HP:0006565)1.99245845
80Renal cortical cysts (HP:0000803)1.99169791
81Microretrognathia (HP:0000308)1.96752090
82Short tibia (HP:0005736)1.96409066
83Hyperventilation (HP:0002883)1.95884160
84Progressive macrocephaly (HP:0004481)1.95756193
85Abnormality of the labia minora (HP:0012880)1.94621939
86True hermaphroditism (HP:0010459)1.94614417
87Increased CSF lactate (HP:0002490)1.92637526
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92452929
89Abnormality of lateral ventricle (HP:0030047)1.91816903
90Duplicated collecting system (HP:0000081)1.90554698
91Brushfield spots (HP:0001088)1.89475558
92Tubular atrophy (HP:0000092)1.89397533
93Abnormality of nail color (HP:0100643)1.88512532
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88363538
95Dicarboxylic aciduria (HP:0003215)1.88363538
96Biliary tract neoplasm (HP:0100574)1.86620873
97Abnormal respiratory motile cilium physiology (HP:0012261)1.86284437
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.84227580
99Mesangial abnormality (HP:0001966)1.83112667
100Renal Fanconi syndrome (HP:0001994)1.82297486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.45087554
2BCKDK4.10658549
3GRK13.62288418
4KDR3.49755920
5VRK23.48345230
6TIE13.14848759
7ADRBK22.56588242
8TESK22.48449248
9LIMK12.30094377
10MAP2K72.22054833
11MAP3K112.20561562
12BRSK22.11357916
13WEE11.86598496
14CDK81.82530710
15BUB11.81184018
16ITK1.77353768
17TLK11.76842532
18VRK11.60822162
19TESK11.56389302
20CAMKK21.42738960
21RPS6KA51.36662267
22TAOK31.33016290
23WNK31.28860468
24MAPKAPK31.28472086
25FRK1.26485295
26CDC71.21854755
27MAP3K41.21786688
28WNK41.08492722
29FER1.07375170
30NUAK11.06649380
31DYRK21.01138017
32MARK11.00077105
33TXK0.95113288
34ABL20.93436928
35PKN10.91284828
36CDK190.90702644
37TEC0.87765900
38CASK0.86782826
39BRSK10.86467615
40OXSR10.80998254
41BMPR1B0.76901460
42STK160.76494912
43GRK50.75839992
44PDK20.69842448
45TAF10.69486631
46TGFBR10.67171673
47PRKCQ0.66891582
48MAPK130.64838792
49RPS6KA20.61743702
50MUSK0.61261065
51MAP4K10.60365875
52MAPKAPK50.59769050
53STK390.59618635
54PLK10.58628294
55DAPK10.58205270
56PLK30.57331570
57STK110.56047458
58ZAK0.55215589
59PINK10.54936551
60RPS6KA60.54829549
61MAP4K20.53671966
62AURKB0.53646098
63CDK90.52581644
64AURKA0.49934731
65CCNB10.49330917
66PLK40.48033214
67NEK10.47297772
68ATR0.45234138
69LCK0.44766215
70SYK0.44091720
71ACVR1B0.41556157
72CSNK2A10.38849179
73CSNK1G30.38611086
74CAMK2D0.38284331
75CAMK2A0.36544718
76EIF2AK20.36173898
77ADRBK10.35612196
78TNK20.33999289
79PRKCE0.33975707
80GRK70.33724876
81RPS6KB10.33419834
82IRAK10.33026716
83PRKCA0.32501601
84PRKCZ0.31889756
85FES0.31445656
86ATM0.31376405
87IKBKB0.30809035
88CSNK1A1L0.30381024
89PRKACA0.30342181
90CAMK2G0.28130289
91CHEK20.26616155
92LYN0.26613437
93CAMK1D0.26563939
94IRAK40.26474567
95CDK70.25658709
96NME10.23859139
97OBSCN0.23474266
98RPS6KC10.22725419
99RPS6KL10.22725419
100DAPK30.22279421

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.44463950
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.67466633
3Oxidative phosphorylation_Homo sapiens_hsa001903.65882150
4Protein export_Homo sapiens_hsa030603.50777109
5Parkinsons disease_Homo sapiens_hsa050123.12977428
6Butanoate metabolism_Homo sapiens_hsa006503.10252833
7Fanconi anemia pathway_Homo sapiens_hsa034602.65124788
8Homologous recombination_Homo sapiens_hsa034402.59055461
9Primary immunodeficiency_Homo sapiens_hsa053402.29646961
10Basal transcription factors_Homo sapiens_hsa030222.20678881
11RNA polymerase_Homo sapiens_hsa030202.15344378
12Huntingtons disease_Homo sapiens_hsa050162.11400209
13Selenocompound metabolism_Homo sapiens_hsa004501.91314431
14DNA replication_Homo sapiens_hsa030301.86104877
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81904340
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81174173
17Mismatch repair_Homo sapiens_hsa034301.73236640
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70393035
19Phototransduction_Homo sapiens_hsa047441.67445240
20Nucleotide excision repair_Homo sapiens_hsa034201.66932006
21Nitrogen metabolism_Homo sapiens_hsa009101.65888990
22Graft-versus-host disease_Homo sapiens_hsa053321.64403473
23Alzheimers disease_Homo sapiens_hsa050101.58923140
24Linoleic acid metabolism_Homo sapiens_hsa005911.57270337
25Autoimmune thyroid disease_Homo sapiens_hsa053201.54972607
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52614385
27Sulfur metabolism_Homo sapiens_hsa009201.52304930
28Ribosome_Homo sapiens_hsa030101.49976133
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48158835
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42852492
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42030798
32Sulfur relay system_Homo sapiens_hsa041221.40792558
33Ether lipid metabolism_Homo sapiens_hsa005651.33743814
34Allograft rejection_Homo sapiens_hsa053301.33659054
35Nicotine addiction_Homo sapiens_hsa050331.26303034
36Pyrimidine metabolism_Homo sapiens_hsa002401.25599547
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22428950
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20577281
39Cardiac muscle contraction_Homo sapiens_hsa042601.16192677
40Taste transduction_Homo sapiens_hsa047421.14855276
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12022657
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.07979204
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01775767
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.92946327
45Type I diabetes mellitus_Homo sapiens_hsa049400.92603341
46Purine metabolism_Homo sapiens_hsa002300.91110096
47Antigen processing and presentation_Homo sapiens_hsa046120.86962063
48Collecting duct acid secretion_Homo sapiens_hsa049660.83795078
49Caffeine metabolism_Homo sapiens_hsa002320.75725658
50Spliceosome_Homo sapiens_hsa030400.74106276
51Hematopoietic cell lineage_Homo sapiens_hsa046400.74077077
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74011802
53Peroxisome_Homo sapiens_hsa041460.71427452
54Tryptophan metabolism_Homo sapiens_hsa003800.70281503
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67561312
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66938205
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65697007
58Cell cycle_Homo sapiens_hsa041100.65549592
59RNA degradation_Homo sapiens_hsa030180.65414221
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65180913
61Base excision repair_Homo sapiens_hsa034100.64704670
62Fatty acid biosynthesis_Homo sapiens_hsa000610.63265560
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63256799
64Metabolic pathways_Homo sapiens_hsa011000.60270089
65Chemical carcinogenesis_Homo sapiens_hsa052040.58126210
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57902528
67One carbon pool by folate_Homo sapiens_hsa006700.55860953
68Shigellosis_Homo sapiens_hsa051310.55530404
69Lysosome_Homo sapiens_hsa041420.47987395
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.45928459
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43924817
72Rheumatoid arthritis_Homo sapiens_hsa053230.43551806
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42944281
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41597642
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38264110
76Olfactory transduction_Homo sapiens_hsa047400.36687857
77Propanoate metabolism_Homo sapiens_hsa006400.35786649
78Asthma_Homo sapiens_hsa053100.33423051
79Arachidonic acid metabolism_Homo sapiens_hsa005900.32710298
80Retinol metabolism_Homo sapiens_hsa008300.32270489
81Steroid biosynthesis_Homo sapiens_hsa001000.31852822
82Viral myocarditis_Homo sapiens_hsa054160.30845287
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29038264
84Fat digestion and absorption_Homo sapiens_hsa049750.27875112
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25617480
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24890764
87RNA transport_Homo sapiens_hsa030130.24428164
88Glutathione metabolism_Homo sapiens_hsa004800.23521090
89Morphine addiction_Homo sapiens_hsa050320.21592271
90T cell receptor signaling pathway_Homo sapiens_hsa046600.21011390
91Epstein-Barr virus infection_Homo sapiens_hsa051690.20476295
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20439452
93Oocyte meiosis_Homo sapiens_hsa041140.19073530
94Measles_Homo sapiens_hsa051620.17616893
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16792948
96Regulation of autophagy_Homo sapiens_hsa041400.16311584
97p53 signaling pathway_Homo sapiens_hsa041150.14831285
98Ovarian steroidogenesis_Homo sapiens_hsa049130.12575816
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12517524
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12224317

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