ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	kinetochore assembly (GO:0051382)	5.11671238
2	kinetochore organization (GO:0051383)	4.90703873
3	protein prenylation (GO:0018342)	4.69307285
4	prenylation (GO:0097354)	4.69307285
5	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.40606024
6	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.32500262
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.08293314
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.08293314
9	NADH dehydrogenase complex assembly (GO:0010257)	4.08293314
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.00808476
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.97415894
12	ATP synthesis coupled proton transport (GO:0015986)	3.97415894
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.91958166
14	iron-sulfur cluster assembly (GO:0016226)	3.79705399
15	metallo-sulfur cluster assembly (GO:0031163)	3.79705399
16	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.78933246
17	DNA deamination (GO:0045006)	3.75674701
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.75131120
19	protein complex biogenesis (GO:0070271)	3.71829294
20	pyrimidine nucleotide catabolic process (GO:0006244)	3.71180565
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66093287
22	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.53835131
23	chaperone-mediated protein transport (GO:0072321)	3.49084773
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.46991477
25	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.46991477
26	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.46660677
27	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.39754223
28	purine nucleobase biosynthetic process (GO:0009113)	3.36342417
29	ribosomal small subunit assembly (GO:0000028)	3.29641526
30	positive regulation of prostaglandin secretion (GO:0032308)	3.28407036
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.28301387
32	deoxyribose phosphate biosynthetic process (GO:0046385)	3.28189442
33	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.28189442
34	regulation of mitochondrial translation (GO:0070129)	3.26083686
35	chromatin remodeling at centromere (GO:0031055)	3.22531471
36	base-excision repair, AP site formation (GO:0006285)	3.21629452
37	ketone body metabolic process (GO:1902224)	3.17258174
38	L-methionine salvage (GO:0071267)	3.15141506
39	L-methionine biosynthetic process (GO:0071265)	3.15141506
40	amino acid salvage (GO:0043102)	3.15141506
41	protein K6-linked ubiquitination (GO:0085020)	3.13438612
42	cellular ketone body metabolic process (GO:0046950)	3.13087633
43	GMP metabolic process (GO:0046037)	3.11768205
44	negative regulation of telomere maintenance (GO:0032205)	3.09048899
45	serotonin metabolic process (GO:0042428)	3.08499603
46	DNA ligation (GO:0006266)	3.07963493
47	neurotransmitter catabolic process (GO:0042135)	3.07243383
48	GTP biosynthetic process (GO:0006183)	3.05466737
49	rRNA modification (GO:0000154)	3.05228048
50	nucleobase biosynthetic process (GO:0046112)	3.05103940
51	deoxyribonucleotide catabolic process (GO:0009264)	3.04739256
52	platelet dense granule organization (GO:0060155)	3.03762925
53	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.00162943
54	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.98741124
55	CENP-A containing nucleosome assembly (GO:0034080)	2.98625297
56	2-deoxyribonucleotide metabolic process (GO:0009394)	2.98269058
57	behavioral response to nicotine (GO:0035095)	2.97380493
58	protein-cofactor linkage (GO:0018065)	2.95556247
59	DNA double-strand break processing (GO:0000729)	2.95411961
60	nonmotile primary cilium assembly (GO:0035058)	2.92684246
61	electron transport chain (GO:0022900)	2.87592288
62	respiratory electron transport chain (GO:0022904)	2.86126692
63	rRNA catabolic process (GO:0016075)	2.85082256
64	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.81090786
65	mismatch repair (GO:0006298)	2.79246052
66	lactate metabolic process (GO:0006089)	2.78587456
67	guanosine-containing compound biosynthetic process (GO:1901070)	2.77438664
68	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.76991624
69	isoprenoid biosynthetic process (GO:0008299)	2.76528277
70	water-soluble vitamin biosynthetic process (GO:0042364)	2.75202381
71	UTP metabolic process (GO:0046051)	2.74482390
72	pyrimidine dimer repair (GO:0006290)	2.74327890
73	protein localization to kinetochore (GO:0034501)	2.73848565
74	deoxyribose phosphate metabolic process (GO:0019692)	2.73804358
75	primary amino compound metabolic process (GO:1901160)	2.72569627
76	deoxyribonucleotide metabolic process (GO:0009262)	2.72016561
77	resolution of meiotic recombination intermediates (GO:0000712)	2.71534227
78	DNA strand renaturation (GO:0000733)	2.70704046
79	organelle disassembly (GO:1903008)	2.70020285
80	microtubule depolymerization (GO:0007019)	2.69849314
81	pseudouridine synthesis (GO:0001522)	2.68582478
82	deoxyribose phosphate catabolic process (GO:0046386)	2.68516203
83	cholesterol biosynthetic process (GO:0006695)	2.68093067
84	termination of RNA polymerase III transcription (GO:0006386)	2.67641949
85	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.67641949
86	DNA integration (GO:0015074)	2.66088686
87	DNA demethylation (GO:0080111)	2.65079226
88	telomere maintenance via semi-conservative replication (GO:0032201)	2.64734058
89	transcription-coupled nucleotide-excision repair (GO:0006283)	2.63951761
90	negative regulation of B cell apoptotic process (GO:0002903)	2.63100005
91	UTP biosynthetic process (GO:0006228)	2.62518067
92	oxidative phosphorylation (GO:0006119)	2.59520949
93	reciprocal meiotic recombination (GO:0007131)	2.58650117
94	reciprocal DNA recombination (GO:0035825)	2.58650117
95	mitotic sister chromatid segregation (GO:0000070)	2.57555283
96	DNA dealkylation (GO:0035510)	2.57056149
97	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.54480338
98	spinal cord association neuron differentiation (GO:0021527)	2.52460876
99	deoxyribonucleotide biosynthetic process (GO:0009263)	2.52410995
100	protein polyglutamylation (GO:0018095)	2.52160159

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.72484559
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.71236885
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.80221094
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.49981735
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.44278137
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.19815502
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.11070294
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.95681300
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.88908263
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.87160812
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82875886
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.82194054
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77776952
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.65286226
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60371274
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.47083684
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.45136335
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.44598548
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.41921550
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41136061
21	VDR_23849224_ChIP-Seq_CD4+_Human	2.32973264
22	E2F7_22180533_ChIP-Seq_HELA_Human	2.21934323
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.17975083
24	MYC_18940864_ChIP-ChIP_HL60_Human	2.15055274
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13538523
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.10637316
27	IRF1_19129219_ChIP-ChIP_H3396_Human	2.03452814
28	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.00344801
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99190669
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.93824329
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92334972
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.90529633
33	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.87945684
34	VDR_22108803_ChIP-Seq_LS180_Human	1.78461455
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.77310299
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.68718865
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.68694188
38	XRN2_22483619_ChIP-Seq_HELA_Human	1.68432404
39	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.68334897
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68217274
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.68043768
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.64599750
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.48742492
44	EZH2_22144423_ChIP-Seq_EOC_Human	1.45878418
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.44827457
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.44793648
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.43181665
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.42439132
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.42237443
50	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.39695843
51	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.31658636
52	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.28494905
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27507781
54	FUS_26573619_Chip-Seq_HEK293_Human	1.26151684
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21504611
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19540159
57	EWS_26573619_Chip-Seq_HEK293_Human	1.19181965
58	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.16582034
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.13382359
60	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.10912581
61	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.08484414
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.05727814
63	ERA_21632823_ChIP-Seq_H3396_Human	1.05432736
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05072205
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04063582
66	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.03681039
67	AR_20517297_ChIP-Seq_VCAP_Human	1.03387267
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.03375249
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03370614
70	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01342130
71	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00398735
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00269314
73	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99405478
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99179792
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99179792
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97175691
77	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96050869
78	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.94288135
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.93758796
80	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93364161
81	GBX2_23144817_ChIP-Seq_PC3_Human	0.93145402
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92964978
83	NCOR_22424771_ChIP-Seq_293T_Human	0.91661157
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91507435
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91507435
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.91379624
87	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.91148595
88	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.91099420
89	CIITA_25753668_ChIP-Seq_RAJI_Human	0.90891339
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.90137165
91	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.88724796
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.88718726
93	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.88164349
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.84772585
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84412015
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.81430160
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.80479481
98	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.78951385
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.78395412
100	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.77750878

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.56122754
2	MP0000372_irregular_coat_pigmentation	3.30884287
3	MP0002102_abnormal_ear_morphology	3.07097727
4	MP0010094_abnormal_chromosome_stability	3.03742455
5	MP0005646_abnormal_pituitary_gland	2.95048558
6	MP0003787_abnormal_imprinting	2.91845210
7	MP0008058_abnormal_DNA_repair	2.88321593
8	MP0003693_abnormal_embryo_hatching	2.67763966
9	MP0003111_abnormal_nucleus_morphology	2.61040075
10	MP0003011_delayed_dark_adaptation	2.58425750
11	MP0005171_absent_coat_pigmentation	2.42299933
12	MP0002095_abnormal_skin_pigmentation	2.13571490
13	MP0004147_increased_porphyrin_level	2.01062674
14	MP0005645_abnormal_hypothalamus_physiol	1.91934094
15	MP0005253_abnormal_eye_physiology	1.90655395
16	MP0003786_premature_aging	1.85063212
17	MP0006036_abnormal_mitochondrial_physio	1.82829357
18	MP0002822_catalepsy	1.82392461
19	MP0008007_abnormal_cellular_replicative	1.71350379
20	MP0005408_hypopigmentation	1.70956797
21	MP0009697_abnormal_copulation	1.68675526
22	MP0003077_abnormal_cell_cycle	1.68574071
23	MP0006292_abnormal_olfactory_placode	1.67962759
24	MP0008789_abnormal_olfactory_epithelium	1.63488757
25	MP0000566_synostosis	1.59816166
26	MP0001986_abnormal_taste_sensitivity	1.56628976
27	MP0006276_abnormal_autonomic_nervous	1.56550929
28	MP0004043_abnormal_pH_regulation	1.55968079
29	MP0001764_abnormal_homeostasis	1.55591655
30	MP0006035_abnormal_mitochondrial_morpho	1.51679288
31	MP0002638_abnormal_pupillary_reflex	1.51375933
32	MP0002736_abnormal_nociception_after	1.50538044
33	MP0004145_abnormal_muscle_electrophysio	1.47951711
34	MP0001529_abnormal_vocalization	1.46535342
35	MP0005499_abnormal_olfactory_system	1.45603327
36	MP0005394_taste/olfaction_phenotype	1.45603327
37	MP0005551_abnormal_eye_electrophysiolog	1.45322485
38	MP0002160_abnormal_reproductive_system	1.43895157
39	MP0006072_abnormal_retinal_apoptosis	1.43274563
40	MP0005075_abnormal_melanosome_morpholog	1.43142531
41	MP0005367_renal/urinary_system_phenotyp	1.42214480
42	MP0000516_abnormal_urinary_system	1.42214480
43	MP0000631_abnormal_neuroendocrine_gland	1.41992108
44	MP0005389_reproductive_system_phenotype	1.41353967
45	MP0003186_abnormal_redox_activity	1.38177295
46	MP0003718_maternal_effect	1.36343884
47	MP0002234_abnormal_pharynx_morphology	1.35895762
48	MP0002090_abnormal_vision	1.33936142
49	MP0002837_dystrophic_cardiac_calcinosis	1.31851695
50	MP0008872_abnormal_physiological_respon	1.26663261
51	MP0005379_endocrine/exocrine_gland_phen	1.25441874
52	MP0001485_abnormal_pinna_reflex	1.23848900
53	MP0003121_genomic_imprinting	1.22709807
54	MP0002938_white_spotting	1.21830901
55	MP0004142_abnormal_muscle_tone	1.21693137
56	MP0003878_abnormal_ear_physiology	1.18232915
57	MP0005377_hearing/vestibular/ear_phenot	1.18232915
58	MP0008995_early_reproductive_senescence	1.16781559
59	MP0005248_abnormal_Harderian_gland	1.14920480
60	MP0000049_abnormal_middle_ear	1.13713017
61	MP0003646_muscle_fatigue	1.13331193
62	MP0003283_abnormal_digestive_organ	1.12941293
63	MP0002653_abnormal_ependyma_morphology	1.11764246
64	MP0001919_abnormal_reproductive_system	1.08578060
65	MP0001929_abnormal_gametogenesis	1.04991164
66	MP0001324_abnormal_eye_pigmentation	1.03896168
67	MP0003136_yellow_coat_color	1.02315394
68	MP0001293_anophthalmia	1.01594179
69	MP0005195_abnormal_posterior_eye	1.01053132
70	MP0003567_abnormal_fetal_cardiomyocyte	1.00567035
71	MP0001968_abnormal_touch/_nociception	1.00482735
72	MP0008932_abnormal_embryonic_tissue	1.00283540
73	MP0009379_abnormal_foot_pigmentation	0.97750997
74	MP0005410_abnormal_fertilization	0.96785166
75	MP0000358_abnormal_cell_content/	0.96117730
76	MP0003698_abnormal_male_reproductive	0.95008073
77	MP0005391_vision/eye_phenotype	0.93306529
78	MP0002909_abnormal_adrenal_gland	0.93187914
79	MP0000647_abnormal_sebaceous_gland	0.92383197
80	MP0002210_abnormal_sex_determination	0.90705075
81	MP0001963_abnormal_hearing_physiology	0.87471995
82	MP0002572_abnormal_emotion/affect_behav	0.86185866
83	MP0003122_maternal_imprinting	0.85789394
84	MP0009745_abnormal_behavioral_response	0.85719469
85	MP0008569_lethality_at_weaning	0.85110557
86	MP0004957_abnormal_blastocyst_morpholog	0.85083948
87	MP0002557_abnormal_social/conspecific_i	0.84892101
88	MP0005084_abnormal_gallbladder_morpholo	0.84398462
89	MP0000653_abnormal_sex_gland	0.83849914
90	MP0005636_abnormal_mineral_homeostasis	0.82909970
91	MP0001145_abnormal_male_reproductive	0.82801233
92	MP0002163_abnormal_gland_morphology	0.81453095
93	MP0000026_abnormal_inner_ear	0.79846005
94	MP0002272_abnormal_nervous_system	0.79291015
95	MP0001270_distended_abdomen	0.78657779
96	MP0002138_abnormal_hepatobiliary_system	0.78088456
97	MP0000015_abnormal_ear_pigmentation	0.77622206
98	MP0003880_abnormal_central_pattern	0.76993775
99	MP0002752_abnormal_somatic_nervous	0.76753092
100	MP0003137_abnormal_impulse_conducting	0.75328124

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.12006055
2	Type II lissencephaly (HP:0007260)	3.95458500
3	Congenital stationary night blindness (HP:0007642)	3.77484478
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.69330516
5	Progressive macrocephaly (HP:0004481)	3.65500669
6	Pancreatic fibrosis (HP:0100732)	3.49509482
7	3-Methylglutaconic aciduria (HP:0003535)	3.48800271
8	Acute encephalopathy (HP:0006846)	3.40407733
9	Abnormality of the labia minora (HP:0012880)	3.30574101
10	Hepatocellular necrosis (HP:0001404)	3.29272653
11	Pendular nystagmus (HP:0012043)	3.27253718
12	Mitochondrial inheritance (HP:0001427)	3.23945109
13	Pancreatic cysts (HP:0001737)	3.22330138
14	Type 2 muscle fiber atrophy (HP:0003554)	3.10992935
15	Increased CSF lactate (HP:0002490)	3.07870979
16	Hepatic necrosis (HP:0002605)	2.93088589
17	Decreased central vision (HP:0007663)	2.89650478
18	Abnormal protein glycosylation (HP:0012346)	2.85801013
19	Abnormal glycosylation (HP:0012345)	2.85801013
20	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.85801013
21	Abnormal protein N-linked glycosylation (HP:0012347)	2.85801013
22	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.85663638
23	Abnormality of midbrain morphology (HP:0002418)	2.79376537
24	Molar tooth sign on MRI (HP:0002419)	2.79376537
25	Muscle fiber atrophy (HP:0100295)	2.76423265
26	True hermaphroditism (HP:0010459)	2.71707898
27	Increased corneal curvature (HP:0100692)	2.71269834
28	Keratoconus (HP:0000563)	2.71269834
29	Oligodactyly (hands) (HP:0001180)	2.68278227
30	Hepatoblastoma (HP:0002884)	2.62053791
31	Methylmalonic acidemia (HP:0002912)	2.54637705
32	Cerebellar dysplasia (HP:0007033)	2.54322674
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.45529643
34	Type I transferrin isoform profile (HP:0003642)	2.42358072
35	Abnormality of the metopic suture (HP:0005556)	2.41292103
36	Retinal dysplasia (HP:0007973)	2.39870498
37	Constricted visual fields (HP:0001133)	2.37771075
38	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.36404090
39	Cerebral edema (HP:0002181)	2.36336683
40	Optic disc pallor (HP:0000543)	2.33753506
41	Lactic acidosis (HP:0003128)	2.31651897
42	Medial flaring of the eyebrow (HP:0010747)	2.28727027
43	Partial agenesis of the corpus callosum (HP:0001338)	2.26117030
44	Colon cancer (HP:0003003)	2.25826438
45	Postaxial foot polydactyly (HP:0001830)	2.25742481
46	Nephronophthisis (HP:0000090)	2.24812664
47	Gait imbalance (HP:0002141)	2.24558256
48	Hyperglycinemia (HP:0002154)	2.23707552
49	Abolished electroretinogram (ERG) (HP:0000550)	2.22320754
50	Increased serum lactate (HP:0002151)	2.22038345
51	Congenital primary aphakia (HP:0007707)	2.22033573
52	Oligodactyly (HP:0012165)	2.19775956
53	Supernumerary spleens (HP:0009799)	2.17698172
54	Abnormality of the ileum (HP:0001549)	2.15250158
55	Neoplasm of the adrenal cortex (HP:0100641)	2.14224576
56	Reduced antithrombin III activity (HP:0001976)	2.13635895
57	Meckel diverticulum (HP:0002245)	2.11492337
58	Abnormal number of incisors (HP:0011064)	2.11208106
59	Microretrognathia (HP:0000308)	2.10339532
60	Prominent metopic ridge (HP:0005487)	2.09790087
61	Lissencephaly (HP:0001339)	2.07849708
62	Absent epiphyses (HP:0010577)	2.07392131
63	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.07392131
64	Chromsome breakage (HP:0040012)	2.06664301
65	Anencephaly (HP:0002323)	2.05237935
66	Opisthotonus (HP:0002179)	2.04810151
67	Chronic hepatic failure (HP:0100626)	2.04746467
68	Flat capital femoral epiphysis (HP:0003370)	2.03458787
69	Abnormality of the carotid arteries (HP:0005344)	2.01214399
70	Abnormality of B cell number (HP:0010975)	1.96421865
71	Nephrogenic diabetes insipidus (HP:0009806)	1.95359031
72	Neoplasm of the adrenal gland (HP:0100631)	1.94582798
73	Postaxial hand polydactyly (HP:0001162)	1.94252439
74	Hypoplastic pelvis (HP:0008839)	1.90669110
75	Optic nerve hypoplasia (HP:0000609)	1.88400569
76	Dicarboxylic aciduria (HP:0003215)	1.87269732
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87269732
78	Gout (HP:0001997)	1.85280475
79	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.85063485
80	Methylmalonic aciduria (HP:0012120)	1.80821102
81	Severe combined immunodeficiency (HP:0004430)	1.79373333
82	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79193348
83	Broad distal phalanx of finger (HP:0009836)	1.78054699
84	Abnormal biliary tract physiology (HP:0012439)	1.77696348
85	Bile duct proliferation (HP:0001408)	1.77696348
86	Abnormality of the renal medulla (HP:0100957)	1.77315462
87	Sclerocornea (HP:0000647)	1.77222971
88	Horseshoe kidney (HP:0000085)	1.75744882
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74221531
90	Genital tract atresia (HP:0001827)	1.73222222
91	Patellar aplasia (HP:0006443)	1.72143625
92	Respiratory failure (HP:0002878)	1.71711996
93	Large for gestational age (HP:0001520)	1.70862298
94	Abnormality of the renal cortex (HP:0011035)	1.69488159
95	Cerebral palsy (HP:0100021)	1.69332195
96	Ketosis (HP:0001946)	1.68228198
97	Leukodystrophy (HP:0002415)	1.68179736
98	Holoprosencephaly (HP:0001360)	1.66352810
99	Lethargy (HP:0001254)	1.66343524
100	B lymphocytopenia (HP:0010976)	1.65754246

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.98931857
2	SRPK1	3.28050924
3	MAP4K2	3.27695262
4	TAOK3	3.20135793
5	CSNK1G3	2.54804350
6	DYRK2	2.42416637
7	CSNK1A1L	2.41924729
8	PIM2	2.28674032
9	WEE1	2.25896943
10	CSNK1G2	2.21039073
11	BUB1	2.16020307
12	VRK1	2.09441175
13	CSNK1G1	2.06707515
14	CCNB1	1.93252195
15	BCKDK	1.90940220
16	ZAK	1.83299853
17	PASK	1.79305805
18	MAP3K4	1.64528605
19	STK39	1.61940730
20	LIMK1	1.61051523
21	EIF2AK2	1.55749171
22	PLK3	1.49857821
23	DYRK1B	1.48544955
24	PLK2	1.44938806
25	ERBB3	1.42593092
26	WNK3	1.42288287
27	WNK4	1.41877340
28	FRK	1.41032065
29	BMPR2	1.34782261
30	NUAK1	1.29530002
31	AURKB	1.29219782
32	TLK1	1.23661125
33	BRSK2	1.21809832
34	PHKG1	1.20340419
35	PHKG2	1.20340419
36	NEK1	1.20128444
37	CAMKK2	1.18937814
38	NME1	1.18844519
39	TAF1	1.18288599
40	DYRK3	1.17799696
41	GRK1	1.17031922
42	EPHA4	1.14625441
43	MAP2K7	1.13843915
44	EIF2AK1	1.12369412
45	CDC7	1.09578245
46	ADRBK2	1.09147225
47	TXK	1.06342771
48	TTK	1.01715848
49	TIE1	1.01488131
50	CDK6	0.99264647
51	INSRR	0.98501420
52	PLK4	0.92509727
53	PLK1	0.91491839
54	PIK3CA	0.89165213
55	EIF2AK3	0.89005003
56	BCR	0.80835569
57	TSSK6	0.74881389
58	ATR	0.72885194
59	CDK7	0.72678324
60	OXSR1	0.68443067
61	MAPK13	0.67826056
62	DAPK3	0.65538660
63	STK16	0.65255406
64	PRKCI	0.65200205
65	STK10	0.64836784
66	BRSK1	0.64776218
67	CHEK2	0.63916332
68	BMPR1B	0.61711241
69	MARK1	0.58842678
70	AURKA	0.57679420
71	RPS6KA4	0.56019847
72	LRRK2	0.53679496
73	CSNK2A1	0.52745350
74	ERBB2	0.50726680
75	PAK3	0.50107374
76	CHEK1	0.49022944
77	CDK9	0.48953330
78	PRKCG	0.48751876
79	CAMK1D	0.46274826
80	MST4	0.45447328
81	CDK14	0.45328847
82	CSNK2A2	0.42286352
83	NEK9	0.42209800
84	UHMK1	0.41692370
85	ATM	0.40855900
86	MARK3	0.40377526
87	PDK2	0.40084669
88	CDK19	0.39607855
89	STK4	0.38323462
90	CSNK1A1	0.36579045
91	CSNK1D	0.36175952
92	TNIK	0.33505042
93	PRKCE	0.32820047
94	NTRK2	0.32498570
95	HIPK2	0.31835777
96	CDK8	0.31618284
97	EPHB2	0.29242966
98	MKNK1	0.28611902
99	PKN1	0.28322149
100	WNK1	0.27807546

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.46630565
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01577389
3	Homologous recombination_Homo sapiens_hsa03440	2.99202018
4	RNA polymerase_Homo sapiens_hsa03020	2.69400516
5	Parkinsons disease_Homo sapiens_hsa05012	2.62950390
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.61470565
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.55588315
8	Mismatch repair_Homo sapiens_hsa03430	2.55211365
9	Steroid biosynthesis_Homo sapiens_hsa00100	2.45133652
10	Butanoate metabolism_Homo sapiens_hsa00650	2.43644471
11	Base excision repair_Homo sapiens_hsa03410	2.40472655
12	DNA replication_Homo sapiens_hsa03030	2.33304438
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31004381
14	Ribosome_Homo sapiens_hsa03010	2.25145212
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.11739384
16	Protein export_Homo sapiens_hsa03060	2.02775788
17	Proteasome_Homo sapiens_hsa03050	1.97711279
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.91161294
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.89987285
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.85192244
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.82160101
22	Huntingtons disease_Homo sapiens_hsa05016	1.75834583
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.74674564
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.70452132
25	Spliceosome_Homo sapiens_hsa03040	1.58765750
26	Alzheimers disease_Homo sapiens_hsa05010	1.53945078
27	One carbon pool by folate_Homo sapiens_hsa00670	1.48735968
28	Basal transcription factors_Homo sapiens_hsa03022	1.47190969
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46113201
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43234985
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42483077
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41059333
33	Peroxisome_Homo sapiens_hsa04146	1.35149527
34	Purine metabolism_Homo sapiens_hsa00230	1.34214442
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.33050265
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29715263
37	RNA degradation_Homo sapiens_hsa03018	1.29125987
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28239972
39	Fatty acid elongation_Homo sapiens_hsa00062	1.21566250
40	RNA transport_Homo sapiens_hsa03013	1.19102566
41	Propanoate metabolism_Homo sapiens_hsa00640	1.18246359
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16991932
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15243645
44	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.13594137
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10002370
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02639335
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.00944760
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93232601
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.90129980
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87292399
51	Carbon metabolism_Homo sapiens_hsa01200	0.85013188
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.83862418
53	Fatty acid degradation_Homo sapiens_hsa00071	0.83345497
54	Metabolic pathways_Homo sapiens_hsa01100	0.83336708
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82559763
56	Sulfur relay system_Homo sapiens_hsa04122	0.79550392
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78577492
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76439973
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.73954864
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.73135356
61	Taste transduction_Homo sapiens_hsa04742	0.67839382
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.67020058
63	Folate biosynthesis_Homo sapiens_hsa00790	0.65448218
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.63943424
65	Nicotine addiction_Homo sapiens_hsa05033	0.61708754
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60923875
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57672140
68	Cell cycle_Homo sapiens_hsa04110	0.56893384
69	Caffeine metabolism_Homo sapiens_hsa00232	0.55425335
70	Olfactory transduction_Homo sapiens_hsa04740	0.51566584
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50955830
72	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.48997757
73	Phototransduction_Homo sapiens_hsa04744	0.47968486
74	Pentose phosphate pathway_Homo sapiens_hsa00030	0.46356828
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.46183367
76	Oocyte meiosis_Homo sapiens_hsa04114	0.45148607
77	Glutathione metabolism_Homo sapiens_hsa00480	0.43531742
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42345027
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42280897
80	p53 signaling pathway_Homo sapiens_hsa04115	0.38360495
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38227118
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37735173
83	Lysine degradation_Homo sapiens_hsa00310	0.37567503
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37517873
85	Asthma_Homo sapiens_hsa05310	0.36726284
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36547833
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.35338524
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33658553
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31945851
90	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31576991
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31136425
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.30734427
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.30614754
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.28240693
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24989005
96	Morphine addiction_Homo sapiens_hsa05032	0.22169138
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.19644807
98	Nitrogen metabolism_Homo sapiens_hsa00910	0.19581566
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.17861316
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.17628873

HMGN2P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »