ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	9.41035526
2	DNA deamination (GO:0045006)	8.92684950
3	cytidine deamination (GO:0009972)	8.53685248
4	cytidine metabolic process (GO:0046087)	8.53685248
5	cytidine catabolic process (GO:0006216)	8.53685248
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.51111031
7	sequestering of actin monomers (GO:0042989)	6.45068643
8	Arp2/3 complex-mediated actin nucleation (GO:0034314)	6.09229932
9	actin nucleation (GO:0045010)	5.39824570
10	negative regulation of T cell apoptotic process (GO:0070233)	4.95942625
11	negative regulation of stress fiber assembly (GO:0051497)	4.52714465
12	regulation of cellular amino acid metabolic process (GO:0006521)	4.29228062
13	cytolysis (GO:0019835)	4.20395904
14	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.17312964
15	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.09302026
16	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	4.06754102
17	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.04778483
18	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	4.04429184
19	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	4.04429184
20	regulation of B cell receptor signaling pathway (GO:0050855)	4.03615428
21	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.03432505
22	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.00132105
23	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.00132105
24	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.00132105
25	T cell migration (GO:0072678)	3.90622710
26	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.89713252
27	pyrimidine nucleoside catabolic process (GO:0046135)	3.85841049
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.85074742
29	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.84324224
30	deoxyribose phosphate biosynthetic process (GO:0046385)	3.84324224
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.79754105
32	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.78052119
33	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.78052119
34	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.76456067
35	negative regulation by host of viral transcription (GO:0043922)	3.76158717
36	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.69513898
37	negative regulation of oxidoreductase activity (GO:0051354)	3.65589973
38	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.62509899
39	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.62342894
40	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.62288541
41	negative regulation of ligase activity (GO:0051352)	3.62288541
42	positive T cell selection (GO:0043368)	3.61063288
43	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.58226103
44	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.52462963
45	regulation of natural killer cell mediated immunity (GO:0002715)	3.52462963
46	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.50303970
47	negative regulation of actin filament bundle assembly (GO:0032232)	3.46620002
48	respiratory electron transport chain (GO:0022904)	3.43523065
49	regulation of T cell apoptotic process (GO:0070232)	3.40159381
50	positive regulation of B cell differentiation (GO:0045579)	3.37547453
51	negative regulation of viral genome replication (GO:0045071)	3.37084832
52	negative T cell selection (GO:0043383)	3.37061344
53	iron-sulfur cluster assembly (GO:0016226)	3.36535760
54	metallo-sulfur cluster assembly (GO:0031163)	3.36535760
55	electron transport chain (GO:0022900)	3.36353930
56	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.34986524
57	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.31798806
58	proteasome assembly (GO:0043248)	3.30611065
59	positive thymic T cell selection (GO:0045059)	3.29254870
60	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.28915740
61	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.26707375
62	ATP synthesis coupled proton transport (GO:0015986)	3.26707375
63	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.26439256
64	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.24956224
65	positive regulation of cell cycle arrest (GO:0071158)	3.22770021
66	purine deoxyribonucleotide catabolic process (GO:0009155)	3.20821799
67	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.19002819
68	positive regulation of interleukin-8 secretion (GO:2000484)	3.18948428
69	macrophage chemotaxis (GO:0048246)	3.18191411
70	positive regulation of cell killing (GO:0031343)	3.15773677
71	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.11996897
72	negative regulation of monooxygenase activity (GO:0032769)	3.10883689
73	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.09117575
74	regulation of cellular amine metabolic process (GO:0033238)	3.08788425
75	deoxyribonucleotide biosynthetic process (GO:0009263)	3.05485418
76	positive regulation of calcium-mediated signaling (GO:0050850)	3.04079593
77	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.04061048
78	mannosylation (GO:0097502)	3.02131263
79	positive regulation of ligase activity (GO:0051351)	3.01435112
80	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.99883506
81	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.97495373
82	positive regulation of T cell chemotaxis (GO:0010820)	2.97099059
83	regulation of T cell chemotaxis (GO:0010819)	2.97099059
84	protein neddylation (GO:0045116)	2.94845575
85	positive regulation of monocyte chemotaxis (GO:0090026)	2.93681452
86	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.91574786
87	pyrimidine-containing compound catabolic process (GO:0072529)	2.85454160
88	regulation of cell killing (GO:0031341)	2.85137650
89	deoxyribonucleotide catabolic process (GO:0009264)	2.83949336
90	positive regulation of translational initiation (GO:0045948)	2.83943786
91	2-deoxyribonucleotide metabolic process (GO:0009394)	2.83185362
92	regulation of B cell differentiation (GO:0045577)	2.81090120
93	GDP-mannose metabolic process (GO:0019673)	2.80059169
94	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.79587098
95	platelet dense granule organization (GO:0060155)	2.75323940
96	positive regulation of interleukin-4 production (GO:0032753)	2.75256833
97	regulation of T cell mediated cytotoxicity (GO:0001914)	2.74235730
98	GPI anchor biosynthetic process (GO:0006506)	2.74195218
99	response to interferon-beta (GO:0035456)	2.71939728
100	regulation of cell cycle arrest (GO:0071156)	2.71656762

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	5.41157953
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.85826382
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.61039277
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.60033135
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45412308
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.29127086
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.22393773
8	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.96334122
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89054397
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75752306
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.73389754
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.65561042
13	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.57151908
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.53308002
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47289178
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37016898
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.35259564
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.21332410
19	MYB_26560356_Chip-Seq_TH2_Human	2.16946335
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13869109
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.13433301
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.11926336
23	VDR_22108803_ChIP-Seq_LS180_Human	1.87848058
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.87385063
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84225522
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.83065634
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.81248534
28	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.81180610
29	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.77588204
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.76204855
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.67264183
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64208920
33	HTT_18923047_ChIP-ChIP_STHdh_Human	1.62650753
34	GATA3_27048872_Chip-Seq_THYMUS_Human	1.61146961
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59995086
36	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.56341810
37	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.55491578
38	GATA3_26560356_Chip-Seq_TH2_Human	1.54075981
39	CIITA_25753668_ChIP-Seq_RAJI_Human	1.53686864
40	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.51854159
41	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.49210124
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.48782719
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47099833
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46665350
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42537727
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.41910968
47	E2F7_22180533_ChIP-Seq_HELA_Human	1.41267671
48	ERG_20517297_ChIP-Seq_VCAP_Human	1.40347396
49	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38041809
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.37377253
51	EZH2_22144423_ChIP-Seq_EOC_Human	1.37233773
52	RUNX_20019798_ChIP-Seq_JUKART_Human	1.26732561
53	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.25974778
54	AR_20517297_ChIP-Seq_VCAP_Human	1.24353798
55	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.21955998
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.20829092
57	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.20144032
58	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20038161
59	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.19910656
60	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.19592441
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19354212
62	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.17007950
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14316339
64	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.13786574
65	UTX_26944678_Chip-Seq_JUKART_Human	1.13226571
66	GABP_19822575_ChIP-Seq_HepG2_Human	1.12987461
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12476225
68	BCL6_27268052_Chip-Seq_Bcells_Human	1.12183586
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09635657
70	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.09183086
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09046008
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08505016
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07117634
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07117634
75	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.06677176
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05016831
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04607968
78	MYB_26560356_Chip-Seq_TH1_Human	1.03952091
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03755534
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01493432
81	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01485654
82	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00619550
83	NCOR_22424771_ChIP-Seq_293T_Human	1.00246603
84	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99436337
85	ER_23166858_ChIP-Seq_MCF-7_Human	0.97732230
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97018830
87	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.96840722
88	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95367513
89	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.93708490
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.93151865
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93151865
92	P300_27268052_Chip-Seq_Bcells_Human	0.92851289
93	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.90721832
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90659775
95	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.90002575
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89940279
97	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89940279
98	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89543847
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88657160
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.87847573

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.56986221
2	MP0003763_abnormal_thymus_physiology	3.23809842
3	MP0009333_abnormal_splenocyte_physiolog	3.06091898
4	MP0001835_abnormal_antigen_presentation	2.84032455
5	MP0009785_altered_susceptibility_to	2.70534842
6	MP0002166_altered_tumor_susceptibility	2.58729285
7	MP0006082_CNS_inflammation	2.40505144
8	MP0005000_abnormal_immune_tolerance	2.01732570
9	MP0002006_tumorigenesis	1.99308418
10	MP0002420_abnormal_adaptive_immunity	1.96341826
11	MP0004147_increased_porphyrin_level	1.93110522
12	MP0001819_abnormal_immune_cell	1.89349693
13	MP0001905_abnormal_dopamine_level	1.87323275
14	MP0000685_abnormal_immune_system	1.85037401
15	MP0005025_abnormal_response_to	1.83757688
16	MP0005377_hearing/vestibular/ear_phenot	1.81481694
17	MP0003878_abnormal_ear_physiology	1.81481694
18	MP0001800_abnormal_humoral_immune	1.80999549
19	MP0005387_immune_system_phenotype	1.78727435
20	MP0001790_abnormal_immune_system	1.78727435
21	MP0002102_abnormal_ear_morphology	1.73846669
22	MP0002723_abnormal_immune_serum	1.72648617
23	MP0003866_abnormal_defecation	1.70541628
24	MP0005645_abnormal_hypothalamus_physiol	1.70394780
25	MP0006072_abnormal_retinal_apoptosis	1.68431430
26	MP0005551_abnormal_eye_electrophysiolog	1.66136588
27	MP0001919_abnormal_reproductive_system	1.63699329
28	MP0001485_abnormal_pinna_reflex	1.59113243
29	MP0000372_irregular_coat_pigmentation	1.55482029
30	MP0005646_abnormal_pituitary_gland	1.54474356
31	MP0003646_muscle_fatigue	1.53751253
32	MP0005451_abnormal_body_composition	1.53299175
33	MP0002148_abnormal_hypersensitivity_rea	1.50122703
34	MP0003252_abnormal_bile_duct	1.47568336
35	MP0008872_abnormal_physiological_respon	1.46833586
36	MP0005253_abnormal_eye_physiology	1.46579659
37	MP0000716_abnormal_immune_system	1.45532956
38	MP0005389_reproductive_system_phenotype	1.44546412
39	MP0001968_abnormal_touch/_nociception	1.41925164
40	MP0001873_stomach_inflammation	1.41628633
41	MP0001764_abnormal_homeostasis	1.41304494
42	MP0002452_abnormal_antigen_presenting	1.41246031
43	MP0002398_abnormal_bone_marrow	1.40618688
44	MP0005075_abnormal_melanosome_morpholog	1.40471955
45	MP0002405_respiratory_system_inflammati	1.36423630
46	MP0002736_abnormal_nociception_after	1.35111496
47	MP0000703_abnormal_thymus_morphology	1.34439773
48	MP0006036_abnormal_mitochondrial_physio	1.33177304
49	MP0005083_abnormal_biliary_tract	1.32096336
50	MP0003011_delayed_dark_adaptation	1.30951956
51	MP0003137_abnormal_impulse_conducting	1.29646214
52	MP0008875_abnormal_xenobiotic_pharmacok	1.28617586
53	MP0002138_abnormal_hepatobiliary_system	1.27027886
54	MP0000689_abnormal_spleen_morphology	1.27019500
55	MP0010386_abnormal_urinary_bladder	1.24233068
56	MP0003567_abnormal_fetal_cardiomyocyte	1.22231864
57	MP0002876_abnormal_thyroid_physiology	1.22212896
58	MP0002722_abnormal_immune_system	1.21434388
59	MP0003786_premature_aging	1.19655319
60	MP0006035_abnormal_mitochondrial_morpho	1.18512238
61	MP0002837_dystrophic_cardiac_calcinosis	1.18146195
62	MP0005084_abnormal_gallbladder_morpholo	1.17653964
63	MP0010155_abnormal_intestine_physiology	1.15016519
64	MP0001845_abnormal_inflammatory_respons	1.14295157
65	MP0006276_abnormal_autonomic_nervous	1.13286991
66	MP0006292_abnormal_olfactory_placode	1.12701540
67	MP0003806_abnormal_nucleotide_metabolis	1.10736717
68	MP0004145_abnormal_muscle_electrophysio	1.10245723
69	MP0001986_abnormal_taste_sensitivity	1.08374931
70	MP0002429_abnormal_blood_cell	1.07633028
71	MP0003693_abnormal_embryo_hatching	1.05832071
72	MP0009764_decreased_sensitivity_to	1.05026612
73	MP0006054_spinal_hemorrhage	1.04921249
74	MP0005410_abnormal_fertilization	1.00026727
75	MP0002160_abnormal_reproductive_system	0.99917253
76	MP0003195_calcinosis	0.98663891
77	MP0003880_abnormal_central_pattern	0.96309188
78	MP0002234_abnormal_pharynx_morphology	0.96108029
79	MP0008877_abnormal_DNA_methylation	0.94578841
80	MP0002933_joint_inflammation	0.94168376
81	MP0002419_abnormal_innate_immunity	0.94067190
82	MP0001529_abnormal_vocalization	0.93732982
83	MP0003448_altered_tumor_morphology	0.93079612
84	MP0009763_increased_sensitivity_to	0.87345578
85	MP0001661_extended_life_span	0.84467727
86	MP0002019_abnormal_tumor_incidence	0.83861573
87	MP0005636_abnormal_mineral_homeostasis	0.82268776
88	MP0008058_abnormal_DNA_repair	0.81011751
89	MP0008469_abnormal_protein_level	0.81007051
90	MP0001984_abnormal_olfaction	0.79531806
91	MP0001765_abnormal_ion_homeostasis	0.79174807
92	MP0005464_abnormal_platelet_physiology	0.77112353
93	MP0000639_abnormal_adrenal_gland	0.77109012
94	MP0002163_abnormal_gland_morphology	0.76359431
95	MP0005085_abnormal_gallbladder_physiolo	0.75927343
96	MP0010094_abnormal_chromosome_stability	0.73503667
97	MP0001501_abnormal_sleep_pattern	0.72878310
98	MP0002277_abnormal_respiratory_mucosa	0.71311915
99	MP0008873_increased_physiological_sensi	0.70475229
100	MP0005166_decreased_susceptibility_to	0.70409138

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.37131232
2	B lymphocytopenia (HP:0010976)	5.17752421
3	Abnormality of B cell number (HP:0010975)	4.79707845
4	T lymphocytopenia (HP:0005403)	4.79483649
5	Severe combined immunodeficiency (HP:0004430)	4.74267256
6	IgG deficiency (HP:0004315)	4.39795618
7	Abnormality of T cell number (HP:0011839)	4.35603517
8	Hypoproteinemia (HP:0003075)	4.19151160
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.06452315
10	Combined immunodeficiency (HP:0005387)	3.96465470
11	Increased IgM level (HP:0003496)	3.94087793
12	Thyroiditis (HP:0100646)	3.87632372
13	Autoimmune hemolytic anemia (HP:0001890)	3.73147644
14	Elevated erythrocyte sedimentation rate (HP:0003565)	3.52926065
15	Mitochondrial inheritance (HP:0001427)	3.51856405
16	Acute necrotizing encephalopathy (HP:0006965)	3.31032264
17	Abnormality of T cells (HP:0002843)	3.28154510
18	Attenuation of retinal blood vessels (HP:0007843)	3.24291330
19	Abnormality of eosinophils (HP:0001879)	3.21451682
20	Decreased central vision (HP:0007663)	3.11699529
21	Hepatocellular necrosis (HP:0001404)	3.06932591
22	Abolished electroretinogram (ERG) (HP:0000550)	3.02906485
23	3-Methylglutaconic aciduria (HP:0003535)	3.02793136
24	Abnormal mitochondria in muscle tissue (HP:0008316)	3.01284542
25	Encephalitis (HP:0002383)	2.96060656
26	Pancytopenia (HP:0001876)	2.93907824
27	Cerebral palsy (HP:0100021)	2.88387382
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.87717432
29	Hepatic necrosis (HP:0002605)	2.86271911
30	Increased CSF lactate (HP:0002490)	2.85387244
31	Type I transferrin isoform profile (HP:0003642)	2.79542754
32	Acute encephalopathy (HP:0006846)	2.78608145
33	Eosinophilia (HP:0001880)	2.76558733
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.71161344
35	Amyotrophic lateral sclerosis (HP:0007354)	2.69735822
36	Autoimmune thrombocytopenia (HP:0001973)	2.69597681
37	Progressive macrocephaly (HP:0004481)	2.67967317
38	Congenital stationary night blindness (HP:0007642)	2.58317783
39	Cerebral edema (HP:0002181)	2.56414060
40	Pendular nystagmus (HP:0012043)	2.52954431
41	Methylmalonic acidemia (HP:0002912)	2.49843225
42	Acute hepatic failure (HP:0006554)	2.48479434
43	Pancreatic cysts (HP:0001737)	2.47841042
44	Hypoplasia of the thymus (HP:0000778)	2.45840676
45	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.45551162
46	Abnormal protein N-linked glycosylation (HP:0012347)	2.45551162
47	Abnormal protein glycosylation (HP:0012346)	2.45551162
48	Abnormal glycosylation (HP:0012345)	2.45551162
49	Chronic diarrhea (HP:0002028)	2.42092973
50	Abnormality of the prostate (HP:0008775)	2.41685313
51	True hermaphroditism (HP:0010459)	2.34049380
52	Lymphopenia (HP:0001888)	2.33267680
53	Increased hepatocellular lipid droplets (HP:0006565)	2.31470807
54	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.30857338
55	Dicarboxylic aciduria (HP:0003215)	2.30857338
56	Optic disc pallor (HP:0000543)	2.29449447
57	Abnormality of midbrain morphology (HP:0002418)	2.29366429
58	Molar tooth sign on MRI (HP:0002419)	2.29366429
59	Pigmentary retinal degeneration (HP:0001146)	2.26992739
60	Leukocytosis (HP:0001974)	2.22355947
61	Hypoalbuminemia (HP:0003073)	2.20521829
62	Abnormal albumin level (HP:0012116)	2.20521829
63	Increased corneal curvature (HP:0100692)	2.18386355
64	Keratoconus (HP:0000563)	2.18386355
65	Hemiplegia (HP:0002301)	2.16260894
66	Chronic mucocutaneous candidiasis (HP:0002728)	2.13708819
67	Recurrent cutaneous fungal infections (HP:0011370)	2.13708819
68	Lipid accumulation in hepatocytes (HP:0006561)	2.11058114
69	Lactic acidosis (HP:0003128)	2.10016975
70	Gastrointestinal infarctions (HP:0005244)	2.08769697
71	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.05810393
72	Methylmalonic aciduria (HP:0012120)	2.05453532
73	Retinal dysplasia (HP:0007973)	2.04783123
74	Pancreatic fibrosis (HP:0100732)	2.04434872
75	Granulocytopenia (HP:0001913)	2.03488137
76	Recurrent bronchitis (HP:0002837)	2.01635894
77	Hypergammaglobulinemia (HP:0010702)	2.01536865
78	Lymphoma (HP:0002665)	2.00308969
79	Tetany (HP:0001281)	1.97154114
80	Increased serum lactate (HP:0002151)	1.97026383
81	IgM deficiency (HP:0002850)	1.96917271
82	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96667396
83	Agammaglobulinemia (HP:0004432)	1.95560111
84	Reduced antithrombin III activity (HP:0001976)	1.95317336
85	Meningitis (HP:0001287)	1.94105857
86	Constricted visual fields (HP:0001133)	1.91431199
87	Cellular immunodeficiency (HP:0005374)	1.89322744
88	Renal Fanconi syndrome (HP:0001994)	1.88106084
89	Respiratory failure (HP:0002878)	1.87632488
90	Abnormality of macrophages (HP:0004311)	1.84718457
91	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84633673
92	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84633673
93	Type 2 muscle fiber atrophy (HP:0003554)	1.84295941
94	Abnormality of T cell physiology (HP:0011840)	1.82460432
95	Lethargy (HP:0001254)	1.82137092
96	Increased intramyocellular lipid droplets (HP:0012240)	1.81101186
97	Ketosis (HP:0001946)	1.78786337
98	Hyperglycinemia (HP:0002154)	1.77366212
99	Generalized aminoaciduria (HP:0002909)	1.75667126
100	Colon cancer (HP:0003003)	1.74524502

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.77221647
2	KDR	5.73763613
3	BCKDK	4.11733795
4	TESK1	3.21427895
5	LIMK1	3.09524422
6	TXK	2.87151027
7	MAP4K2	2.78299356
8	VRK2	2.45705599
9	BUB1	2.43030155
10	MAP4K1	2.29683130
11	MAP3K11	1.98853282
12	MAP3K12	1.97575440
13	MAP2K7	1.70129493
14	TNK2	1.65735861
15	ITK	1.65578754
16	TAOK3	1.56504082
17	VRK1	1.54808506
18	RPS6KA4	1.48659651
19	MAPKAPK3	1.39922798
20	CSNK1G3	1.39830541
21	BCR	1.39746568
22	ZAK	1.35492309
23	GRK1	1.31887581
24	DAPK1	1.31398729
25	ADRBK2	1.26010080
26	CSNK1A1L	1.20507292
27	GRK6	1.19160195
28	FES	1.17511230
29	NUAK1	1.13911491
30	SYK	1.13022457
31	SCYL2	1.12886819
32	ERBB3	1.11187715
33	TEC	1.08900094
34	WNK4	1.07655026
35	CSNK1G2	1.06582844
36	PRKCQ	1.02422297
37	EIF2AK3	1.01016501
38	CSNK1G1	1.00756473
39	TLK1	0.94085618
40	CSF1R	0.90507798
41	SRPK1	0.88740972
42	BTK	0.86684081
43	LCK	0.82411959
44	TRIM28	0.76261961
45	WNK3	0.76085451
46	DYRK2	0.75345153
47	RPS6KA5	0.75095519
48	LYN	0.74800490
49	MAP3K5	0.74657452
50	FRK	0.72916239
51	PIM2	0.70711200
52	AURKA	0.68500124
53	INSRR	0.63369790
54	MYLK	0.63174419
55	CDK19	0.62685907
56	EPHA4	0.60155218
57	TIE1	0.60128967
58	GRK7	0.59904322
59	MAPK13	0.59620198
60	ZAP70	0.59577936
61	CCNB1	0.59520829
62	PINK1	0.58908523
63	MUSK	0.58172199
64	CSK	0.56135613
65	OBSCN	0.55625195
66	ATR	0.53511232
67	PLK2	0.52963097
68	MST4	0.50241433
69	CLK1	0.50214590
70	OXSR1	0.48515608
71	IKBKE	0.47926189
72	TAF1	0.46392645
73	AURKB	0.45533184
74	STK39	0.45135183
75	MAP3K4	0.43705160
76	PASK	0.43532701
77	CDK8	0.43472716
78	NEK1	0.42440805
79	BLK	0.42278421
80	PIK3CG	0.38327137
81	BMPR1B	0.37024821
82	CSNK1A1	0.36722818
83	GRK5	0.34962456
84	FYN	0.34672119
85	IGF1R	0.34133235
86	CSNK2A1	0.34057894
87	ROCK1	0.33192898
88	KIT	0.33104630
89	PLK4	0.32436446
90	CAMKK2	0.30635904
91	PAK1	0.29432654
92	PRKACA	0.29364753
93	PRKCA	0.27946929
94	TBK1	0.26908591
95	DYRK1B	0.26743372
96	PLK1	0.26565708
97	CDK14	0.24029190
98	ADRBK1	0.22751492
99	DAPK3	0.22561193
100	CDK18	0.21222692

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.96179098
2	Primary immunodeficiency_Homo sapiens_hsa05340	5.16301505
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.52727214
4	Parkinsons disease_Homo sapiens_hsa05012	3.09524069
5	Antigen processing and presentation_Homo sapiens_hsa04612	2.75884126
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.42015716
7	RNA polymerase_Homo sapiens_hsa03020	2.32171915
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23279816
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.20630323
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.12598200
11	Alzheimers disease_Homo sapiens_hsa05010	2.10891353
12	Huntingtons disease_Homo sapiens_hsa05016	1.96634423
13	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.93018660
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.81445943
15	Homologous recombination_Homo sapiens_hsa03440	1.76825807
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.76693310
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.76501850
18	Allograft rejection_Homo sapiens_hsa05330	1.74469248
19	Protein export_Homo sapiens_hsa03060	1.73200240
20	DNA replication_Homo sapiens_hsa03030	1.64927764
21	Phototransduction_Homo sapiens_hsa04744	1.58228793
22	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.56128380
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.46857191
24	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.41859904
25	Shigellosis_Homo sapiens_hsa05131	1.31447860
26	Mismatch repair_Homo sapiens_hsa03430	1.30048299
27	Butanoate metabolism_Homo sapiens_hsa00650	1.29945609
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28746917
29	Ribosome_Homo sapiens_hsa03010	1.27729615
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24108163
31	Spliceosome_Homo sapiens_hsa03040	1.19711257
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14401048
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05630967
34	Propanoate metabolism_Homo sapiens_hsa00640	1.00602825
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98571457
36	Peroxisome_Homo sapiens_hsa04146	0.97101294
37	Purine metabolism_Homo sapiens_hsa00230	0.95772800
38	Base excision repair_Homo sapiens_hsa03410	0.95720870
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94336349
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89741118
41	Nitrogen metabolism_Homo sapiens_hsa00910	0.88828100
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86911324
43	Measles_Homo sapiens_hsa05162	0.83243173
44	Viral myocarditis_Homo sapiens_hsa05416	0.81407941
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.79148164
46	Olfactory transduction_Homo sapiens_hsa04740	0.78793251
47	Salmonella infection_Homo sapiens_hsa05132	0.77709106
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77497177
49	Caffeine metabolism_Homo sapiens_hsa00232	0.76243289
50	RNA degradation_Homo sapiens_hsa03018	0.74691996
51	Fatty acid elongation_Homo sapiens_hsa00062	0.72136375
52	Rheumatoid arthritis_Homo sapiens_hsa05323	0.71845474
53	Regulation of autophagy_Homo sapiens_hsa04140	0.71222953
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70694377
55	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70519333
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67582662
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66970110
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65898876
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64856011
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.61907006
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61724383
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.61282464
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59605336
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.59118924
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57251780
66	Retinol metabolism_Homo sapiens_hsa00830	0.56117846
67	One carbon pool by folate_Homo sapiens_hsa00670	0.56002244
68	Taste transduction_Homo sapiens_hsa04742	0.55854764
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.55233895
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52097623
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51062314
72	Metabolic pathways_Homo sapiens_hsa01100	0.50621985
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50478068
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49816460
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.49104329
76	Nicotine addiction_Homo sapiens_hsa05033	0.46255665
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46169779
78	Malaria_Homo sapiens_hsa05144	0.41928477
79	Asthma_Homo sapiens_hsa05310	0.41449043
80	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.41174051
81	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40383512
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39603348
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38372913
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.37035174
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34521079
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34504962
87	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.32221737
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32040409
89	Herpes simplex infection_Homo sapiens_hsa05168	0.31711749
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.31701582
91	RNA transport_Homo sapiens_hsa03013	0.27934790
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26607716
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26590879
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.24998548
95	Folate biosynthesis_Homo sapiens_hsa00790	0.23645044
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.21980406
97	Alcoholism_Homo sapiens_hsa05034	0.19554766
98	GABAergic synapse_Homo sapiens_hsa04727	0.18646324
99	Basal transcription factors_Homo sapiens_hsa03022	0.18602737
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.17776213

HMGN2P27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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