ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA methylation involved in gamete generation (GO:0043046)	8.11600608
2	male meiosis I (GO:0007141)	7.02743051
3	male meiosis (GO:0007140)	6.69675290
4	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	6.34979220
5	sphingosine metabolic process (GO:0006670)	6.20083986
6	positive regulation of meiosis (GO:0045836)	6.17605256
7	regulation of meiosis I (GO:0060631)	5.97922572
8	cellular extravasation (GO:0045123)	5.95069317
9	meiosis I (GO:0007127)	5.89950814
10	positive regulation of meiotic cell cycle (GO:0051446)	5.74908644
11	neutrophil mediated immunity (GO:0002446)	5.74810226
12	diol metabolic process (GO:0034311)	5.58780469
13	auditory receptor cell differentiation (GO:0042491)	5.49886949
14	regulation of chemokine biosynthetic process (GO:0045073)	5.32144046
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.07097455
16	regulation of interleukin-8 biosynthetic process (GO:0045414)	4.89547587
17	endothelium development (GO:0003158)	4.88733287
18	sphingoid metabolic process (GO:0046519)	4.84955330
19	synaptonemal complex assembly (GO:0007130)	4.80390021
20	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	4.71315094
21	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	4.71315094
22	chromosome organization involved in meiosis (GO:0070192)	4.67908978
23	gene silencing by RNA (GO:0031047)	4.67591874
24	synapsis (GO:0007129)	4.66744823
25	DNA synthesis involved in DNA repair (GO:0000731)	4.64934223
26	meiotic nuclear division (GO:0007126)	4.46711899
27	negative regulation of interleukin-8 production (GO:0032717)	4.30486925
28	negative regulation of growth of symbiont in host (GO:0044130)	4.27830401
29	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	4.27830401
30	modulation of growth of symbiont involved in interaction with host (GO:0044144)	4.27830401
31	regulation of growth of symbiont in host (GO:0044126)	4.27830401
32	synaptonemal complex organization (GO:0070193)	4.16868793
33	aggressive behavior (GO:0002118)	4.16115796
34	negative regulation of chemokine production (GO:0032682)	4.09521453
35	myeloid leukocyte mediated immunity (GO:0002444)	4.09157281
36	positive regulation of B cell differentiation (GO:0045579)	4.00878792
37	regulation of MHC class II biosynthetic process (GO:0045346)	3.81724213
38	reciprocal meiotic recombination (GO:0007131)	3.78159639
39	reciprocal DNA recombination (GO:0035825)	3.78159639
40	sphingomyelin metabolic process (GO:0006684)	3.70991951
41	negative regulation of phagocytosis (GO:0050765)	3.70905665
42	hair cell differentiation (GO:0035315)	3.68375709
43	cellular response to exogenous dsRNA (GO:0071360)	3.66851258
44	protein complex biogenesis (GO:0070271)	3.59560538
45	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.59494519
46	seminiferous tubule development (GO:0072520)	3.59412748
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59386162
48	NADH dehydrogenase complex assembly (GO:0010257)	3.59386162
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59386162
50	mannosylation (GO:0097502)	3.53698718
51	organic cation transport (GO:0015695)	3.53162905
52	regulation of DNA endoreduplication (GO:0032875)	3.52349258
53	epithelial cilium movement (GO:0003351)	3.51654656
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.44951702
55	protein localization to peroxisome (GO:0072662)	3.44420568
56	protein targeting to peroxisome (GO:0006625)	3.44420568
57	establishment of protein localization to peroxisome (GO:0072663)	3.44420568
58	positive regulation of histone H3-K4 methylation (GO:0051571)	3.43860777
59	meiotic chromosome segregation (GO:0045132)	3.36759709
60	pyrimidine dimer repair (GO:0006290)	3.35571048
61	meiotic cell cycle process (GO:1903046)	3.35453003
62	mitochondrial respiratory chain complex assembly (GO:0033108)	3.35210574
63	gonadal mesoderm development (GO:0007506)	3.33150341
64	DNA alkylation (GO:0006305)	3.32250842
65	DNA methylation (GO:0006306)	3.32250842
66	glomerular filtration (GO:0003094)	3.24209614
67	tRNA modification (GO:0006400)	3.12009685
68	response to misfolded protein (GO:0051788)	3.09069760
69	fucose catabolic process (GO:0019317)	3.08589232
70	L-fucose metabolic process (GO:0042354)	3.08589232
71	L-fucose catabolic process (GO:0042355)	3.08589232
72	protein K6-linked ubiquitination (GO:0085020)	3.07078738
73	resolution of meiotic recombination intermediates (GO:0000712)	3.05210634
74	axoneme assembly (GO:0035082)	3.04099602
75	cilium or flagellum-dependent cell motility (GO:0001539)	3.03352601
76	mitochondrial DNA replication (GO:0006264)	3.02600404
77	peroxisomal transport (GO:0043574)	3.00694280
78	sister chromatid cohesion (GO:0007062)	2.98675726
79	protein targeting to Golgi (GO:0000042)	2.95955538
80	carnitine transmembrane transport (GO:1902603)	2.95054511
81	meiotic cell cycle (GO:0051321)	2.94044545
82	carnitine transport (GO:0015879)	2.92392188
83	amino-acid betaine transport (GO:0015838)	2.92392188
84	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	2.91245615
85	histone H3-K36 demethylation (GO:0070544)	2.88932961
86	establishment of protein localization to Golgi (GO:0072600)	2.86250929
87	regulation of MHC class I biosynthetic process (GO:0045343)	2.81664668
88	rRNA modification (GO:0000154)	2.81154948
89	DNA methylation or demethylation (GO:0044728)	2.80699049
90	ribosomal small subunit assembly (GO:0000028)	2.79746372
91	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.79615517
92	pyrimidine nucleotide catabolic process (GO:0006244)	2.78686175
93	microglial cell activation (GO:0001774)	2.78635604
94	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	2.77646678
95	mismatch repair (GO:0006298)	2.76645726
96	photoreceptor cell maintenance (GO:0045494)	2.75945820
97	renal filtration (GO:0097205)	2.75340378
98	lysosome localization (GO:0032418)	2.74861996
99	gene silencing (GO:0016458)	2.72712908
100	piRNA metabolic process (GO:0034587)	11.3041117

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.58862870
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.49025953
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92843378
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.77287554
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.05478210
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.94845004
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.79080463
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.41317526
9	FUS_26573619_Chip-Seq_HEK293_Human	2.35216934
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.32026069
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.17304942
12	VDR_22108803_ChIP-Seq_LS180_Human	2.16454708
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.08131562
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06126446
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.05005386
16	BCAT_22108803_ChIP-Seq_LS180_Human	1.97066530
17	CBP_20019798_ChIP-Seq_JUKART_Human	1.88884239
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.88884239
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.83603396
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.76087789
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.60720960
22	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.56105555
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52561480
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52540303
25	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.51530827
26	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.49584375
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.48339635
28	EWS_26573619_Chip-Seq_HEK293_Human	1.45347970
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44113404
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43713563
31	SCL_19346495_ChIP-Seq_HPC-7_Human	1.42371176
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38752823
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.37442574
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.36993532
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34572012
36	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.34169366
37	STAT3_23295773_ChIP-Seq_U87_Human	1.33330483
38	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32361509
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.32300345
40	TCF4_23295773_ChIP-Seq_U87_Human	1.32164637
41	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30845672
42	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.29905665
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27955167
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26444920
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25837864
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25837864
47	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25070937
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.24284884
49	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23422235
50	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22675384
51	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20393419
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19004941
53	NCOR_22424771_ChIP-Seq_293T_Human	1.16719314
54	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16385202
55	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.15625588
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14981385
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13917884
58	P300_19829295_ChIP-Seq_ESCs_Human	1.13669336
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12768921
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.12673345
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12358239
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11899745
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09400800
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09246483
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08744916
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08003213
67	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.07997754
68	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06656278
69	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06646313
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05821753
71	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.04515916
72	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03579889
73	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03458370
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03250837
75	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03049169
76	P300_18555785_Chip-Seq_ESCs_Mouse	1.02946665
77	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.02683976
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.02399871
79	BRD4_25478319_ChIP-Seq_HGPS_Human	1.02149908
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01939636
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.01648901
82	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98743374
83	AR_20517297_ChIP-Seq_VCAP_Human	0.98728266
84	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.98715238
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95948526
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94980932
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94980932
88	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94930616
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94462824
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94462824
91	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.94364631
92	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.94056599
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.93766880
94	AR_25329375_ChIP-Seq_VCAP_Human	0.93470883
95	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.93098462
96	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.92975192
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.92815052
98	SPI1_23547873_ChIP-Seq_NB4_Human	0.90422233
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90100840
100	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.90060937

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.98718726
2	MP0006054_spinal_hemorrhage	5.00620368
3	MP0005360_urolithiasis	4.09503124
4	MP0008058_abnormal_DNA_repair	3.11614009
5	MP0000383_abnormal_hair_follicle	2.98641642
6	MP0005174_abnormal_tail_pigmentation	2.97257383
7	MP0010368_abnormal_lymphatic_system	2.69728707
8	MP0001986_abnormal_taste_sensitivity	2.61324685
9	MP0000569_abnormal_digit_pigmentation	2.39407490
10	MP0005464_abnormal_platelet_physiology	2.27317901
11	MP0000372_irregular_coat_pigmentation	2.21908564
12	MP0005397_hematopoietic_system_phenotyp	2.21061109
13	MP0001545_abnormal_hematopoietic_system	2.21061109
14	MP0001929_abnormal_gametogenesis	2.19155594
15	MP0005075_abnormal_melanosome_morpholog	2.06520888
16	MP0000465_gastrointestinal_hemorrhage	1.89968926
17	MP0008057_abnormal_DNA_replication	1.86918151
18	MP0001145_abnormal_male_reproductive	1.82900689
19	MP0003950_abnormal_plasma_membrane	1.80057163
20	MP0002210_abnormal_sex_determination	1.74515986
21	MP0000653_abnormal_sex_gland	1.72261685
22	MP0003698_abnormal_male_reproductive	1.69811987
23	MP0010678_abnormal_skin_adnexa	1.68704678
24	MP0005670_abnormal_white_adipose	1.66717428
25	MP0005551_abnormal_eye_electrophysiolog	1.66620495
26	MP0006072_abnormal_retinal_apoptosis	1.63885638
27	MP0000013_abnormal_adipose_tissue	1.62101635
28	MP0003724_increased_susceptibility_to	1.59691506
29	MP0004185_abnormal_adipocyte_glucose	1.56039651
30	MP0008260_abnormal_autophagy	1.52438859
31	MP0003183_abnormal_peptide_metabolism	1.49831482
32	MP0005220_abnormal_exocrine_pancreas	1.47652674
33	MP0000015_abnormal_ear_pigmentation	1.46538038
34	MP0001835_abnormal_antigen_presentation	1.44837624
35	MP0004084_abnormal_cardiac_muscle	1.43272363
36	MP0005409_darkened_coat_color	1.41000625
37	MP0001485_abnormal_pinna_reflex	1.38548605
38	MP0003656_abnormal_erythrocyte_physiolo	1.37136277
39	MP0002837_dystrophic_cardiac_calcinosis	1.35240226
40	MP0002160_abnormal_reproductive_system	1.26993487
41	MP0006035_abnormal_mitochondrial_morpho	1.23542018
42	MP0001765_abnormal_ion_homeostasis	1.18392013
43	MP0005332_abnormal_amino_acid	1.17852786
44	MP0006036_abnormal_mitochondrial_physio	1.15711597
45	MP0004215_abnormal_myocardial_fiber	1.13946307
46	MP0002138_abnormal_hepatobiliary_system	1.13132295
47	MP0004808_abnormal_hematopoietic_stem	1.09476460
48	MP0005646_abnormal_pituitary_gland	1.09384122
49	MP0001984_abnormal_olfaction	1.07210083
50	MP0001119_abnormal_female_reproductive	1.06580546
51	MP0001486_abnormal_startle_reflex	1.05934120
52	MP0005666_abnormal_adipose_tissue	1.03805163
53	MP0003172_abnormal_lysosome_physiology	1.03419141
54	MP0005636_abnormal_mineral_homeostasis	1.01871140
55	MP0001764_abnormal_homeostasis	0.99922394
56	MP0005410_abnormal_fertilization	0.99684943
57	MP0003567_abnormal_fetal_cardiomyocyte	0.98842948
58	MP0008789_abnormal_olfactory_epithelium	0.96603297
59	MP0000003_abnormal_adipose_tissue	0.95571542
60	MP0001800_abnormal_humoral_immune	0.95081867
61	MP0005389_reproductive_system_phenotype	0.93527921
62	MP0002419_abnormal_innate_immunity	0.93079768
63	MP0002161_abnormal_fertility/fecundity	0.91932890
64	MP0008995_early_reproductive_senescence	0.91641660
65	MP0002095_abnormal_skin_pigmentation	0.89435586
66	MP0005025_abnormal_response_to	0.87856470
67	MP0008004_abnormal_stomach_pH	0.85820005
68	MP0006292_abnormal_olfactory_placode	0.85753944
69	MP0003252_abnormal_bile_duct	0.85431866
70	MP0010329_abnormal_lipoprotein_level	0.82921807
71	MP0003699_abnormal_female_reproductive	0.82158910
72	MP0000230_abnormal_systemic_arterial	0.81808700
73	MP0008873_increased_physiological_sensi	0.81073344
74	MP0002234_abnormal_pharynx_morphology	0.80754811
75	MP0005375_adipose_tissue_phenotype	0.80522604
76	MP0009278_abnormal_bone_marrow	0.78151970
77	MP0002139_abnormal_hepatobiliary_system	0.78106201
78	MP0000613_abnormal_salivary_gland	0.77817925
79	MP0001270_distended_abdomen	0.76776702
80	MP0005330_cardiomyopathy	0.74364338
81	MP0000371_diluted_coat_color	0.73312063
82	MP0000639_abnormal_adrenal_gland	0.71680142
83	MP0004142_abnormal_muscle_tone	0.70686331
84	MP0002136_abnormal_kidney_physiology	0.69176159
85	MP0009643_abnormal_urine_homeostasis	0.69072334
86	MP0002722_abnormal_immune_system	0.68866122
87	MP0004782_abnormal_surfactant_physiolog	0.68567652
88	MP0009763_increased_sensitivity_to	0.67714794
89	MP0010094_abnormal_chromosome_stability	0.67053670
90	MP0000689_abnormal_spleen_morphology	0.65066747
91	MP0004043_abnormal_pH_regulation	0.63148676
92	MP0005253_abnormal_eye_physiology	0.63083235
93	MP0002420_abnormal_adaptive_immunity	0.62706496
94	MP0004134_abnormal_chest_morphology	0.62131705
95	MP0001819_abnormal_immune_cell	0.61586451
96	MP0003718_maternal_effect	0.61171496
97	MP0006276_abnormal_autonomic_nervous	0.60721424
98	MP0002971_abnormal_brown_adipose	0.59654775
99	MP0005084_abnormal_gallbladder_morpholo	0.59040235
100	MP0003786_premature_aging	0.58724258

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sensory axonal neuropathy (HP:0003390)	7.70148563
2	Thrombocytosis (HP:0001894)	6.32413578
3	Tubulointerstitial nephritis (HP:0001970)	4.74123027
4	Tubular atrophy (HP:0000092)	4.28258932
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.89908967
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.80513777
7	Abnormality of the renal cortex (HP:0011035)	3.54407324
8	Chromsome breakage (HP:0040012)	3.52196306
9	Pancreatic cysts (HP:0001737)	3.51641340
10	Spontaneous abortion (HP:0005268)	3.43734990
11	Pigmentary retinal degeneration (HP:0001146)	3.41758727
12	Reticulocytopenia (HP:0001896)	3.38015085
13	Eosinophilia (HP:0001880)	3.33142879
14	Abnormality of DNA repair (HP:0003254)	3.32279868
15	Pancreatic fibrosis (HP:0100732)	3.29355593
16	Brushfield spots (HP:0001088)	3.20771879
17	B lymphocytopenia (HP:0010976)	3.14969376
18	Abnormality of B cell number (HP:0010975)	3.00673163
19	Renal Fanconi syndrome (HP:0001994)	2.96278797
20	Granulocytopenia (HP:0001913)	2.87278210
21	Hepatocellular necrosis (HP:0001404)	2.85742795
22	Abnormal number of erythroid precursors (HP:0012131)	2.84311266
23	Cerebral hypomyelination (HP:0006808)	2.77490320
24	Abnormal biliary tract physiology (HP:0012439)	2.72392734
25	Bile duct proliferation (HP:0001408)	2.72392734
26	Duplicated collecting system (HP:0000081)	2.70445296
27	Microvesicular hepatic steatosis (HP:0001414)	2.61649469
28	Abnormality of the prostate (HP:0008775)	2.60695177
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.60275751
30	Hepatic necrosis (HP:0002605)	2.59917902
31	Polydipsia (HP:0001959)	2.58070945
32	Abnormal drinking behavior (HP:0030082)	2.58070945
33	Lipid accumulation in hepatocytes (HP:0006561)	2.57223794
34	Abnormality of the right ventricle (HP:0001707)	2.53895739
35	Periodontitis (HP:0000704)	2.49748266
36	Abnormality of cells of the erythroid lineage (HP:0012130)	2.49694382
37	Abnormality of the renal collecting system (HP:0004742)	2.49387764
38	Chronic hepatic failure (HP:0100626)	2.48193942
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.46441853
40	Volvulus (HP:0002580)	2.36445371
41	Abnormality of eosinophils (HP:0001879)	2.36232458
42	Panhypogammaglobulinemia (HP:0003139)	2.32353085
43	Renal cortical cysts (HP:0000803)	2.32277034
44	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.30024254
45	Enlarged kidneys (HP:0000105)	2.26487241
46	Chronic diarrhea (HP:0002028)	2.23167872
47	Increased intramyocellular lipid droplets (HP:0012240)	2.22937640
48	Molar tooth sign on MRI (HP:0002419)	2.22870093
49	Abnormality of midbrain morphology (HP:0002418)	2.22870093
50	Increased muscle lipid content (HP:0009058)	2.20330718
51	Ectopic kidney (HP:0000086)	2.20143998
52	Tubulointerstitial abnormality (HP:0001969)	2.19832184
53	Conjugated hyperbilirubinemia (HP:0002908)	2.16916055
54	Nephronophthisis (HP:0000090)	2.16896800
55	Absent thumb (HP:0009777)	2.16284724
56	Increased hepatocellular lipid droplets (HP:0006565)	2.15693518
57	Duplication of thumb phalanx (HP:0009942)	2.07006119
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05574907
59	Abnormality of the renal medulla (HP:0100957)	2.05501755
60	Severe visual impairment (HP:0001141)	2.04531227
61	Abnormality of transition element cation homeostasis (HP:0011030)	2.04212215
62	Cystic liver disease (HP:0006706)	2.03095700
63	Erythroderma (HP:0001019)	2.02994151
64	Neurodegeneration (HP:0002180)	2.02392329
65	Abolished electroretinogram (ERG) (HP:0000550)	2.02220799
66	Portal hypertension (HP:0001409)	2.02030701
67	Elevated erythrocyte sedimentation rate (HP:0003565)	1.98897000
68	Chest pain (HP:0100749)	1.97983308
69	Mitochondrial inheritance (HP:0001427)	1.97908594
70	Abnormality of pyrimidine metabolism (HP:0004353)	1.97527418
71	True hermaphroditism (HP:0010459)	1.96716592
72	Thyroid-stimulating hormone excess (HP:0002925)	1.96217702
73	Agammaglobulinemia (HP:0004432)	1.95401787
74	Facial shape deformation (HP:0011334)	1.93767078
75	Potter facies (HP:0002009)	1.93767078
76	Hypoproteinemia (HP:0003075)	1.89617335
77	Unilateral renal agenesis (HP:0000122)	1.87419991
78	Colon cancer (HP:0003003)	1.87391138
79	Nephrogenic diabetes insipidus (HP:0009806)	1.86307538
80	Dry hair (HP:0011359)	1.85408040
81	Obstructive lung disease (HP:0006536)	1.84957698
82	Chronic obstructive pulmonary disease (HP:0006510)	1.84957698
83	Abnormality of the hepatic vasculature (HP:0006707)	1.83922406
84	Dyschromatopsia (HP:0007641)	1.82710507
85	Congenital hepatic fibrosis (HP:0002612)	1.82442531
86	Lower limb hyperreflexia (HP:0002395)	1.81292471
87	Abnormality of the ileum (HP:0001549)	1.80392114
88	Multicystic kidney dysplasia (HP:0000003)	1.78928440
89	Acute myeloid leukemia (HP:0004808)	1.78911283
90	Abnormality of fatty-acid metabolism (HP:0004359)	1.78067844
91	Abnormality of renal resorption (HP:0011038)	1.77090875
92	Petechiae (HP:0000967)	1.76095418
93	Abnormality of urine glucose concentration (HP:0011016)	1.74744279
94	Glycosuria (HP:0003076)	1.74744279
95	Hemiparesis (HP:0001269)	1.72548884
96	Meckel diverticulum (HP:0002245)	1.71625678
97	Hypergonadotropic hypogonadism (HP:0000815)	1.67461671
98	Generalized aminoaciduria (HP:0002909)	1.66705940
99	Abnormality of chromosome stability (HP:0003220)	1.66198589
100	Abnormal glycosylation (HP:0012345)	1.63866817

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	3.97187804
2	MAP4K2	3.37319484
3	BCKDK	3.26523020
4	PINK1	3.05740024
5	TAOK3	2.82208342
6	STK38L	2.60538247
7	MUSK	2.51327576
8	FRK	2.50345292
9	STK3	2.33888270
10	NME2	2.32396790
11	TRIM28	2.27432695
12	TAF1	2.14800165
13	STK39	2.01029352
14	VRK2	2.00065095
15	BMPR1B	1.88400345
16	OXSR1	1.77318195
17	NEK9	1.76736510
18	ACVR1B	1.76599592
19	RPS6KA4	1.69406750
20	PBK	1.65245175
21	NUAK1	1.60539920
22	VRK1	1.58113958
23	CSF1R	1.50932574
24	TEC	1.49897735
25	TNK2	1.46937603
26	STK4	1.39557178
27	STK24	1.36593616
28	BRD4	1.34270722
29	PAK3	1.29202698
30	KIT	1.22779186
31	ZAK	1.21888175
32	PDK2	1.20604855
33	PRKD2	1.17647898
34	CDK9	1.17373061
35	ATR	1.17046571
36	PLK2	1.16026346
37	SYK	1.14031761
38	CDK4	1.10103217
39	CDK12	1.09522059
40	NLK	1.08067508
41	MST4	1.05157353
42	TXK	1.02925894
43	MAP2K3	1.01242852
44	ADRBK2	0.95583599
45	PRKCE	0.91221257
46	WNK4	0.88025938
47	BTK	0.82152320
48	CHEK1	0.79168007
49	HCK	0.78729486
50	CDK6	0.77401971
51	MAP3K5	0.76373019
52	ATM	0.75515233
53	GRK1	0.74396517
54	FES	0.73416908
55	GSK3A	0.68990930
56	RPS6KA5	0.68486571
57	BMX	0.68029476
58	STK38	0.68020009
59	TAOK1	0.67939622
60	ITK	0.65069837
61	MARK3	0.62316409
62	DYRK1A	0.61914869
63	MAPK13	0.58651559
64	MAP2K1	0.58230047
65	TBK1	0.53622604
66	LCK	0.52628614
67	IKBKE	0.52624605
68	MAP2K6	0.52068754
69	TNIK	0.51954166
70	IKBKB	0.51016973
71	EPHA4	0.50709388
72	CDC7	0.50406743
73	OBSCN	0.50269784
74	IGF1R	0.49534052
75	CLK1	0.47149295
76	BMPR2	0.46601618
77	WNK3	0.46501168
78	PIK3CA	0.44727246
79	CAMK1	0.43706784
80	RPS6KB1	0.43514509
81	RET	0.43146607
82	SGK3	0.41602031
83	MAPK3	0.41257230
84	FGFR2	0.39909937
85	DDR2	0.39335249
86	CHEK2	0.38575817
87	CAMK2D	0.36853434
88	LYN	0.36753737
89	SGK1	0.36703526
90	ABL1	0.36287358
91	CSNK1G2	0.35053105
92	EIF2AK3	0.34960279
93	CSNK2A2	0.34728168
94	PRKCH	0.34257394
95	CSNK1A1	0.33866425
96	MAPK11	0.32601676
97	WNK1	0.31759516
98	ZAP70	0.31599675
99	CDK3	0.30534911
100	PRKCQ	0.29496718

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.55732539
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.35801777
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.28201443
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.94096877
5	Asthma_Homo sapiens_hsa05310	2.77773284
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.55772075
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.48217325
8	Sphingolipid metabolism_Homo sapiens_hsa00600	2.24824476
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10697936
10	Peroxisome_Homo sapiens_hsa04146	2.06274366
11	RNA polymerase_Homo sapiens_hsa03020	1.94704186
12	Basal transcription factors_Homo sapiens_hsa03022	1.94297422
13	Protein export_Homo sapiens_hsa03060	1.86069823
14	Base excision repair_Homo sapiens_hsa03410	1.83431447
15	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.83306272
16	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.79049179
17	Propanoate metabolism_Homo sapiens_hsa00640	1.75218841
18	Homologous recombination_Homo sapiens_hsa03440	1.71464252
19	Regulation of autophagy_Homo sapiens_hsa04140	1.65430623
20	Renin-angiotensin system_Homo sapiens_hsa04614	1.57952631
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53138458
22	Retinol metabolism_Homo sapiens_hsa00830	1.49662114
23	Phototransduction_Homo sapiens_hsa04744	1.49260573
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.43715583
25	Mismatch repair_Homo sapiens_hsa03430	1.38931264
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.31720604
27	Ribosome_Homo sapiens_hsa03010	1.30985053
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.28911889
29	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.24520977
30	Purine metabolism_Homo sapiens_hsa00230	1.23383239
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22999727
32	Sulfur metabolism_Homo sapiens_hsa00920	1.21518769
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.20752499
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20557075
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.17766105
36	Fatty acid degradation_Homo sapiens_hsa00071	1.12410473
37	DNA replication_Homo sapiens_hsa03030	1.10410744
38	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.07708098
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.06276545
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04576247
41	Caffeine metabolism_Homo sapiens_hsa00232	1.02289700
42	Renin secretion_Homo sapiens_hsa04924	1.00177859
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99908022
44	Primary immunodeficiency_Homo sapiens_hsa05340	0.99716396
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.96374457
46	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.94850521
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94843676
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.91904405
49	One carbon pool by folate_Homo sapiens_hsa00670	0.89480331
50	Butanoate metabolism_Homo sapiens_hsa00650	0.89078364
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87408508
52	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.83025921
53	Complement and coagulation cascades_Homo sapiens_hsa04610	0.82717950
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82239143
55	Platelet activation_Homo sapiens_hsa04611	0.80550336
56	Huntingtons disease_Homo sapiens_hsa05016	0.75652983
57	Salivary secretion_Homo sapiens_hsa04970	0.75259921
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73311304
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73153793
60	RNA transport_Homo sapiens_hsa03013	0.71675341
61	p53 signaling pathway_Homo sapiens_hsa04115	0.67881866
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.67129772
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66552001
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66152597
65	Fatty acid elongation_Homo sapiens_hsa00062	0.62248079
66	Notch signaling pathway_Homo sapiens_hsa04330	0.60376555
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59616006
68	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.58148472
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57689442
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57244355
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57100618
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56685006
73	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.56411904
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54942852
75	African trypanosomiasis_Homo sapiens_hsa05143	0.54673165
76	Antigen processing and presentation_Homo sapiens_hsa04612	0.54431895
77	Olfactory transduction_Homo sapiens_hsa04740	0.52927035
78	Oxidative phosphorylation_Homo sapiens_hsa00190	0.52545756
79	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.52501615
80	ABC transporters_Homo sapiens_hsa02010	0.51395382
81	Metabolic pathways_Homo sapiens_hsa01100	0.48044204
82	Oocyte meiosis_Homo sapiens_hsa04114	0.46830090
83	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.46803274
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.46265678
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.40843771
86	Parkinsons disease_Homo sapiens_hsa05012	0.39397049
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39326721
88	RNA degradation_Homo sapiens_hsa03018	0.38796773
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38113782
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37924123
91	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.36569551
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.34971669
93	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.34261240
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32622473
95	Insulin secretion_Homo sapiens_hsa04911	0.31438065
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.30574944
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.24735707
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.21961031
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.20886010
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.20644799

HMGN2P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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