Rank | Gene Set | Z-score |
---|---|---|
1 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 6.05156018 |
2 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 6.05156018 |
3 | establishment of integrated proviral latency (GO:0075713) | 5.55405055 |
4 | sequestering of actin monomers (GO:0042989) | 5.39392088 |
5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.18998461 |
6 | regulation of mitochondrial translation (GO:0070129) | 4.87392802 |
7 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.77712998 |
8 | maturation of SSU-rRNA (GO:0030490) | 4.68852734 |
9 | proteasome assembly (GO:0043248) | 4.33187573 |
10 | establishment of viral latency (GO:0019043) | 4.31829234 |
11 | ribosomal large subunit biogenesis (GO:0042273) | 4.28652052 |
12 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.25225143 |
13 | NADH dehydrogenase complex assembly (GO:0010257) | 4.25225143 |
14 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.25225143 |
15 | galactose catabolic process (GO:0019388) | 4.20374644 |
16 | ATP synthesis coupled proton transport (GO:0015986) | 4.14755886 |
17 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.14755886 |
18 | ribosomal small subunit assembly (GO:0000028) | 4.10657336 |
19 | rRNA modification (GO:0000154) | 4.03388680 |
20 | protein complex biogenesis (GO:0070271) | 3.97943061 |
21 | chaperone-mediated protein transport (GO:0072321) | 3.96977505 |
22 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.94236552 |
23 | DNA ligation (GO:0006266) | 3.92223635 |
24 | ribosome biogenesis (GO:0042254) | 3.92146448 |
25 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.83325264 |
26 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.80162754 |
27 | DNA strand elongation (GO:0022616) | 3.79077803 |
28 | mitochondrial RNA metabolic process (GO:0000959) | 3.78248414 |
29 | inner mitochondrial membrane organization (GO:0007007) | 3.78221257 |
30 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.75226326 |
31 | mitotic sister chromatid segregation (GO:0000070) | 3.70626754 |
32 | peptidyl-histidine modification (GO:0018202) | 3.68530208 |
33 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.64683142 |
34 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.62368334 |
35 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.62253096 |
36 | cellular component biogenesis (GO:0044085) | 3.60718953 |
37 | neurofilament cytoskeleton organization (GO:0060052) | 3.59689765 |
38 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.59084524 |
39 | CENP-A containing nucleosome assembly (GO:0034080) | 3.57220644 |
40 | purine nucleotide salvage (GO:0032261) | 3.54475111 |
41 | rRNA methylation (GO:0031167) | 3.53406784 |
42 | regulation of plasminogen activation (GO:0010755) | 3.51626457 |
43 | homocysteine metabolic process (GO:0050667) | 3.51353140 |
44 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.46875931 |
45 | termination of RNA polymerase III transcription (GO:0006386) | 3.46875931 |
46 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.41412355 |
47 | neurotransmitter catabolic process (GO:0042135) | 3.41042827 |
48 | respiratory electron transport chain (GO:0022904) | 3.40786834 |
49 | chromatin remodeling at centromere (GO:0031055) | 3.40203236 |
50 | pseudouridine synthesis (GO:0001522) | 3.40145376 |
51 | galactose metabolic process (GO:0006012) | 3.39903572 |
52 | electron transport chain (GO:0022900) | 3.37356981 |
53 | histone arginine methylation (GO:0034969) | 3.35899419 |
54 | DNA strand renaturation (GO:0000733) | 3.35077987 |
55 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.34851617 |
56 | viral transcription (GO:0019083) | 3.32842105 |
57 | DNA unwinding involved in DNA replication (GO:0006268) | 3.31892949 |
58 | transcription from mitochondrial promoter (GO:0006390) | 3.30775973 |
59 | positive regulation of endothelial cell differentiation (GO:0045603) | 3.30154958 |
60 | microtubule depolymerization (GO:0007019) | 3.25231402 |
61 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.23717536 |
62 | tRNA modification (GO:0006400) | 3.22363065 |
63 | sister chromatid segregation (GO:0000819) | 3.21393910 |
64 | adenosine metabolic process (GO:0046085) | 3.20048507 |
65 | translational termination (GO:0006415) | 3.13203094 |
66 | IMP biosynthetic process (GO:0006188) | 3.11857800 |
67 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.09000074 |
68 | GMP metabolic process (GO:0046037) | 3.08714619 |
69 | spliceosomal snRNP assembly (GO:0000387) | 3.06960883 |
70 | regulation of spindle organization (GO:0090224) | 3.04719613 |
71 | L-serine metabolic process (GO:0006563) | 3.02022908 |
72 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.00909274 |
73 | ribosomal small subunit biogenesis (GO:0042274) | 3.00874912 |
74 | DNA replication-independent nucleosome organization (GO:0034724) | 3.00317112 |
75 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.00317112 |
76 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.99790904 |
77 | positive regulation of amino acid transport (GO:0051957) | 2.99383861 |
78 | translational elongation (GO:0006414) | 2.98745621 |
79 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.97306689 |
80 | sulfur amino acid catabolic process (GO:0000098) | 2.94505100 |
81 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.92267704 |
82 | histone exchange (GO:0043486) | 2.91752173 |
83 | cotranslational protein targeting to membrane (GO:0006613) | 2.90970853 |
84 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 2.90861024 |
85 | tRNA processing (GO:0008033) | 2.89610778 |
86 | mitotic recombination (GO:0006312) | 2.89280150 |
87 | protein targeting to ER (GO:0045047) | 2.86792694 |
88 | peptidyl-arginine N-methylation (GO:0035246) | 2.86181854 |
89 | peptidyl-arginine methylation (GO:0018216) | 2.86181854 |
90 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.84283608 |
91 | microtubule nucleation (GO:0007020) | 2.82584760 |
92 | intermediate filament organization (GO:0045109) | 2.81008834 |
93 | rRNA processing (GO:0006364) | 2.80839582 |
94 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.79893154 |
95 | maturation of 5.8S rRNA (GO:0000460) | 2.79737704 |
96 | mitotic metaphase plate congression (GO:0007080) | 2.79737121 |
97 | histone-serine phosphorylation (GO:0035404) | 2.78722394 |
98 | replication fork processing (GO:0031297) | 2.78544078 |
99 | V(D)J recombination (GO:0033151) | 2.76417159 |
100 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.75518120 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.20466585 |
2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.69933392 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.96481704 |
4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.95823761 |
5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.89305715 |
6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.86375861 |
7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.81786581 |
8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.78163484 |
9 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.68960046 |
10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.67856175 |
11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.48710988 |
12 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.43958908 |
13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.09189799 |
14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.06053998 |
15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.02425107 |
16 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.89131947 |
17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.78457665 |
18 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.71253016 |
19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.67080783 |
20 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.50568314 |
21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.50357241 |
22 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.45702702 |
23 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.44775419 |
24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.37319000 |
25 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.32723285 |
26 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.32493407 |
27 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.12019172 |
28 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.11516758 |
29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.10424468 |
30 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.02345010 |
31 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.02100689 |
32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.01588057 |
33 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.01064586 |
34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.97801216 |
35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.95440509 |
36 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.90579915 |
37 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.87620987 |
38 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.84191983 |
39 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.77755470 |
40 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.75994988 |
41 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.74534785 |
42 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.71928222 |
43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.67197613 |
44 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.63480753 |
45 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.56229443 |
46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48624052 |
47 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.47207088 |
48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.44350538 |
49 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.43625369 |
50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.41282998 |
51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.41072984 |
52 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.39248021 |
53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.38369829 |
54 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.35367049 |
55 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.32901473 |
56 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.27190417 |
57 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.26818797 |
58 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.25650605 |
59 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.25357142 |
60 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23242337 |
61 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.21069478 |
62 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.16690720 |
63 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.13041818 |
64 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.09658252 |
65 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.08748195 |
66 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.08726228 |
67 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.08602149 |
68 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.05096399 |
69 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.04304300 |
70 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03554675 |
71 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.02000588 |
72 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.00544610 |
73 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.99740047 |
74 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.97758971 |
75 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.97413353 |
76 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.92963082 |
77 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.92763749 |
78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.92055290 |
79 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.91964783 |
80 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.91407598 |
81 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.89693017 |
82 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.89587515 |
83 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.88598213 |
84 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.87332992 |
85 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84254555 |
86 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.82500251 |
87 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.82122087 |
88 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.80830397 |
89 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.79261444 |
90 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.78467884 |
91 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.76117020 |
92 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.74563741 |
93 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.74265053 |
94 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.73736145 |
95 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.72580579 |
96 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.70118923 |
97 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.69563849 |
98 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.69288694 |
99 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.69287897 |
100 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.68342773 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0000537_abnormal_urethra_morphology | 3.60210726 |
2 | MP0005360_urolithiasis | 3.58457713 |
3 | MP0010094_abnormal_chromosome_stability | 3.42313265 |
4 | MP0002735_abnormal_chemical_nociception | 3.10511945 |
5 | MP0010030_abnormal_orbit_morphology | 2.97447856 |
6 | MP0008058_abnormal_DNA_repair | 2.94855211 |
7 | MP0002234_abnormal_pharynx_morphology | 2.84352003 |
8 | MP0009379_abnormal_foot_pigmentation | 2.51724220 |
9 | MP0003693_abnormal_embryo_hatching | 2.46534163 |
10 | MP0003111_abnormal_nucleus_morphology | 2.45955243 |
11 | MP0003806_abnormal_nucleotide_metabolis | 2.31734763 |
12 | MP0006292_abnormal_olfactory_placode | 2.15869886 |
13 | MP0002938_white_spotting | 2.15813232 |
14 | MP0004185_abnormal_adipocyte_glucose | 2.15397615 |
15 | MP0001346_abnormal_lacrimal_gland | 2.11162475 |
16 | MP0005075_abnormal_melanosome_morpholog | 2.10874745 |
17 | MP0003786_premature_aging | 2.08866967 |
18 | MP0000516_abnormal_urinary_system | 2.04551086 |
19 | MP0005367_renal/urinary_system_phenotyp | 2.04551086 |
20 | MP0008932_abnormal_embryonic_tissue | 2.04443324 |
21 | MP0009053_abnormal_anal_canal | 2.04006031 |
22 | MP0004957_abnormal_blastocyst_morpholog | 1.99433601 |
23 | MP0004381_abnormal_hair_follicle | 1.93475589 |
24 | MP0003077_abnormal_cell_cycle | 1.91979997 |
25 | MP0000647_abnormal_sebaceous_gland | 1.88063326 |
26 | MP0003705_abnormal_hypodermis_morpholog | 1.87954312 |
27 | MP0008995_early_reproductive_senescence | 1.86983802 |
28 | MP0002736_abnormal_nociception_after | 1.85612381 |
29 | MP0000013_abnormal_adipose_tissue | 1.70247819 |
30 | MP0008057_abnormal_DNA_replication | 1.67556588 |
31 | MP0003315_abnormal_perineum_morphology | 1.66158609 |
32 | MP0005670_abnormal_white_adipose | 1.65327923 |
33 | MP0000566_synostosis | 1.65256729 |
34 | MP0000534_abnormal_ureter_morphology | 1.63560188 |
35 | MP0002163_abnormal_gland_morphology | 1.62997456 |
36 | MP0002095_abnormal_skin_pigmentation | 1.56560438 |
37 | MP0005197_abnormal_uvea_morphology | 1.54648189 |
38 | MP0005646_abnormal_pituitary_gland | 1.54341310 |
39 | MP0001529_abnormal_vocalization | 1.50864893 |
40 | MP0002653_abnormal_ependyma_morphology | 1.50078298 |
41 | MP0001542_abnormal_bone_strength | 1.48677867 |
42 | MP0004885_abnormal_endolymph | 1.41548443 |
43 | MP0003119_abnormal_digestive_system | 1.32807995 |
44 | MP0003183_abnormal_peptide_metabolism | 1.31971111 |
45 | MP0005257_abnormal_intraocular_pressure | 1.23787527 |
46 | MP0008789_abnormal_olfactory_epithelium | 1.17247383 |
47 | MP0010386_abnormal_urinary_bladder | 1.15663974 |
48 | MP0003718_maternal_effect | 1.10128208 |
49 | MP0008007_abnormal_cellular_replicative | 1.10053037 |
50 | MP0000750_abnormal_muscle_regeneration | 1.08905652 |
51 | MP0001661_extended_life_span | 1.06431440 |
52 | MP0002282_abnormal_trachea_morphology | 1.03775100 |
53 | MP0000372_irregular_coat_pigmentation | 1.01120800 |
54 | MP0003890_abnormal_embryonic-extraembry | 1.00293728 |
55 | MP0000631_abnormal_neuroendocrine_gland | 0.99764574 |
56 | MP0006072_abnormal_retinal_apoptosis | 0.96505131 |
57 | MP0002396_abnormal_hematopoietic_system | 0.96378241 |
58 | MP0001853_heart_inflammation | 0.96111597 |
59 | MP0003186_abnormal_redox_activity | 0.95421506 |
60 | MP0003950_abnormal_plasma_membrane | 0.94209116 |
61 | MP0001243_abnormal_dermal_layer | 0.92333193 |
62 | MP0003942_abnormal_urinary_system | 0.89533877 |
63 | MP0006035_abnormal_mitochondrial_morpho | 0.88694455 |
64 | MP0001730_embryonic_growth_arrest | 0.88401420 |
65 | MP0009250_abnormal_appendicular_skeleto | 0.87259250 |
66 | MP0003191_abnormal_cellular_cholesterol | 0.86883379 |
67 | MP0001756_abnormal_urination | 0.85787662 |
68 | MP0001293_anophthalmia | 0.84962882 |
69 | MP0000490_abnormal_crypts_of | 0.84733886 |
70 | MP0002638_abnormal_pupillary_reflex | 0.84069318 |
71 | MP0003938_abnormal_ear_development | 0.81581319 |
72 | MP0000538_abnormal_urinary_bladder | 0.81338625 |
73 | MP0000733_abnormal_muscle_development | 0.80010999 |
74 | MP0004133_heterotaxia | 0.78419846 |
75 | MP0003943_abnormal_hepatobiliary_system | 0.76648328 |
76 | MP0004147_increased_porphyrin_level | 0.73335164 |
77 | MP0001286_abnormal_eye_development | 0.73048914 |
78 | MP0008775_abnormal_heart_ventricle | 0.71917928 |
79 | MP0005623_abnormal_meninges_morphology | 0.71758420 |
80 | MP0002075_abnormal_coat/hair_pigmentati | 0.71505961 |
81 | MP0009697_abnormal_copulation | 0.70695757 |
82 | MP0008873_increased_physiological_sensi | 0.69924973 |
83 | MP0002932_abnormal_joint_morphology | 0.69725943 |
84 | MP0002210_abnormal_sex_determination | 0.69283976 |
85 | MP0001666_abnormal_nutrient_absorption | 0.69282787 |
86 | MP0003136_yellow_coat_color | 0.69098849 |
87 | MP0000358_abnormal_cell_content/ | 0.68539923 |
88 | MP0005551_abnormal_eye_electrophysiolog | 0.68019605 |
89 | MP0005408_hypopigmentation | 0.67688377 |
90 | MP0002085_abnormal_embryonic_tissue | 0.66982697 |
91 | MP0000026_abnormal_inner_ear | 0.64696706 |
92 | MP0001697_abnormal_embryo_size | 0.64685791 |
93 | MP0009333_abnormal_splenocyte_physiolog | 0.64557897 |
94 | MP0001727_abnormal_embryo_implantation | 0.63802654 |
95 | MP0005076_abnormal_cell_differentiation | 0.63480486 |
96 | MP0009780_abnormal_chondrocyte_physiolo | 0.62508741 |
97 | MP0001919_abnormal_reproductive_system | 0.62152935 |
98 | MP0001944_abnormal_pancreas_morphology | 0.61869466 |
99 | MP0005195_abnormal_posterior_eye | 0.61525262 |
100 | MP0002160_abnormal_reproductive_system | 0.61493364 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Hyperalaninemia (HP:0003348) | 6.51458780 |
2 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 6.51458780 |
3 | Abnormality of alanine metabolism (HP:0010916) | 6.51458780 |
4 | Ulnar claw (HP:0001178) | 4.65853167 |
5 | Birth length less than 3rd percentile (HP:0003561) | 4.60445691 |
6 | Abnormal number of erythroid precursors (HP:0012131) | 4.48540437 |
7 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.34557765 |
8 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.51149551 |
9 | Reduced subcutaneous adipose tissue (HP:0003758) | 3.32053124 |
10 | Reticulocytopenia (HP:0001896) | 3.28501225 |
11 | Increased serum lactate (HP:0002151) | 3.26662818 |
12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.16871530 |
13 | Segmental peripheral demyelination/remyelination (HP:0003481) | 2.99919532 |
14 | Hepatocellular necrosis (HP:0001404) | 2.94651336 |
15 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.93969755 |
16 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.93969755 |
17 | Single umbilical artery (HP:0001195) | 2.93969755 |
18 | Mitochondrial inheritance (HP:0001427) | 2.85677654 |
19 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.84044519 |
20 | Lipid accumulation in hepatocytes (HP:0006561) | 2.75156498 |
21 | Concave nail (HP:0001598) | 2.74680725 |
22 | Acute necrotizing encephalopathy (HP:0006965) | 2.72128216 |
23 | Hepatic necrosis (HP:0002605) | 2.71989557 |
24 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.70570611 |
25 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.68083300 |
26 | Increased serum pyruvate (HP:0003542) | 2.66217503 |
27 | Increased hepatocellular lipid droplets (HP:0006565) | 2.65247316 |
28 | Increased CSF lactate (HP:0002490) | 2.65137809 |
29 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.59127728 |
30 | Microglossia (HP:0000171) | 2.55537721 |
31 | Abnormality of glycolysis (HP:0004366) | 2.52660155 |
32 | Abnormality of chromosome stability (HP:0003220) | 2.52108841 |
33 | Chromsome breakage (HP:0040012) | 2.50532061 |
34 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.50317995 |
35 | Acute encephalopathy (HP:0006846) | 2.49647716 |
36 | Meckel diverticulum (HP:0002245) | 2.46612652 |
37 | Generalized aminoaciduria (HP:0002909) | 2.45831613 |
38 | Lactic acidosis (HP:0003128) | 2.44262968 |
39 | Distal lower limb amyotrophy (HP:0008944) | 2.43753961 |
40 | Lower limb amyotrophy (HP:0007210) | 2.42474477 |
41 | Decreased subcutaneous fat (HP:0001002) | 2.40611371 |
42 | Pigmentary retinal degeneration (HP:0001146) | 2.40291917 |
43 | Renal cortical cysts (HP:0000803) | 2.38460731 |
44 | Abnormality of the preputium (HP:0100587) | 2.33299843 |
45 | Maternal diabetes (HP:0009800) | 2.32350569 |
46 | Constricted visual fields (HP:0001133) | 2.31660897 |
47 | Exercise intolerance (HP:0003546) | 2.29946242 |
48 | Anencephaly (HP:0002323) | 2.28396318 |
49 | Reduced antithrombin III activity (HP:0001976) | 2.26749880 |
50 | Progressive muscle weakness (HP:0003323) | 2.26450181 |
51 | Abnormality of the carotid arteries (HP:0005344) | 2.23746465 |
52 | Methylmalonic acidemia (HP:0002912) | 2.22617497 |
53 | Abnormality of serum amino acid levels (HP:0003112) | 2.21781106 |
54 | Abnormality of the ileum (HP:0001549) | 2.20997396 |
55 | Abnormality of the umbilical cord (HP:0010881) | 2.20193559 |
56 | Increased intramyocellular lipid droplets (HP:0012240) | 2.17777950 |
57 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.16500733 |
58 | Congenital sensorineural hearing impairment (HP:0008527) | 2.16482966 |
59 | Sclerocornea (HP:0000647) | 2.15621051 |
60 | Poor speech (HP:0002465) | 2.14300270 |
61 | Breast hypoplasia (HP:0003187) | 2.11201534 |
62 | Macrocytic anemia (HP:0001972) | 2.09768969 |
63 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.09601093 |
64 | Upper limb muscle weakness (HP:0003484) | 2.08829459 |
65 | Abnormality of the labia minora (HP:0012880) | 2.05290362 |
66 | Congenital, generalized hypertrichosis (HP:0004540) | 2.03040270 |
67 | Renal Fanconi syndrome (HP:0001994) | 2.01232802 |
68 | Small intestinal stenosis (HP:0012848) | 2.00044336 |
69 | Duodenal stenosis (HP:0100867) | 2.00044336 |
70 | Increased muscle lipid content (HP:0009058) | 1.99942163 |
71 | High anterior hairline (HP:0009890) | 1.95784794 |
72 | Aplastic anemia (HP:0001915) | 1.95218019 |
73 | Cerebral edema (HP:0002181) | 1.95205522 |
74 | Bone marrow hypocellularity (HP:0005528) | 1.88596638 |
75 | Progressive macrocephaly (HP:0004481) | 1.87121834 |
76 | Triphalangeal thumb (HP:0001199) | 1.86377454 |
77 | Brittle hair (HP:0002299) | 1.83865458 |
78 | Glucose intolerance (HP:0000833) | 1.83451060 |
79 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.83408177 |
80 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.83033207 |
81 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.82764378 |
82 | Pendular nystagmus (HP:0012043) | 1.82002607 |
83 | Severe combined immunodeficiency (HP:0004430) | 1.78258156 |
84 | Absent thumb (HP:0009777) | 1.75753530 |
85 | Duplicated collecting system (HP:0000081) | 1.74592905 |
86 | Severe muscular hypotonia (HP:0006829) | 1.74062733 |
87 | Opisthotonus (HP:0002179) | 1.74022350 |
88 | Methylmalonic aciduria (HP:0012120) | 1.73910009 |
89 | Difficulty climbing stairs (HP:0003551) | 1.73803361 |
90 | Exertional dyspnea (HP:0002875) | 1.72080573 |
91 | Prolonged neonatal jaundice (HP:0006579) | 1.71424828 |
92 | Patellar aplasia (HP:0006443) | 1.71298676 |
93 | Carpal bone hypoplasia (HP:0001498) | 1.71256849 |
94 | True hermaphroditism (HP:0010459) | 1.70829262 |
95 | Delayed CNS myelination (HP:0002188) | 1.68792927 |
96 | Nasolacrimal duct obstruction (HP:0000579) | 1.66841618 |
97 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.66525436 |
98 | Proximal placement of thumb (HP:0009623) | 1.66189857 |
99 | Abnormality of placental membranes (HP:0011409) | 1.64864288 |
100 | Amniotic constriction ring (HP:0009775) | 1.64864288 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 5.85461311 |
2 | BUB1 | 4.79189463 |
3 | TESK2 | 3.21827271 |
4 | VRK1 | 3.06522508 |
5 | MAP4K2 | 3.02338241 |
6 | ACVR1B | 2.99286553 |
7 | CCNB1 | 2.71951942 |
8 | TLK1 | 2.69585891 |
9 | NEK1 | 2.61021476 |
10 | NME2 | 2.44485789 |
11 | NEK2 | 2.18252832 |
12 | MST4 | 2.10074540 |
13 | TESK1 | 2.09724465 |
14 | AURKA | 1.98334776 |
15 | TAF1 | 1.93292705 |
16 | TRIB3 | 1.75761553 |
17 | STK10 | 1.74220912 |
18 | LIMK1 | 1.58484082 |
19 | MST1R | 1.57238388 |
20 | KDR | 1.55915245 |
21 | PAK4 | 1.55198434 |
22 | AURKB | 1.51346743 |
23 | CDC7 | 1.39195212 |
24 | BCKDK | 1.29945568 |
25 | BMPR1B | 1.29479992 |
26 | EPHB2 | 1.28871764 |
27 | MAP2K3 | 1.26418886 |
28 | STK16 | 1.24882825 |
29 | EIF2AK1 | 1.24658159 |
30 | RPS6KB2 | 1.10554106 |
31 | SIK2 | 1.09208910 |
32 | CDK7 | 1.08441736 |
33 | SMG1 | 1.04757240 |
34 | CHEK2 | 1.03522380 |
35 | ILK | 1.01987417 |
36 | SIK1 | 1.01810454 |
37 | ADRBK1 | 1.00632819 |
38 | BRSK1 | 0.99729366 |
39 | PLK3 | 0.97357015 |
40 | ATR | 0.97100438 |
41 | NUAK1 | 0.95170127 |
42 | ZAK | 0.94390842 |
43 | PLK1 | 0.93854695 |
44 | TGFBR1 | 0.90764522 |
45 | PIM2 | 0.84646248 |
46 | EIF2AK2 | 0.84006427 |
47 | DAPK1 | 0.83400548 |
48 | DYRK2 | 0.80059293 |
49 | PDK2 | 0.79865667 |
50 | PLK4 | 0.79025328 |
51 | EPHA2 | 0.78479528 |
52 | WEE1 | 0.76226930 |
53 | CDK9 | 0.74596155 |
54 | MAP3K12 | 0.74523668 |
55 | PASK | 0.72554151 |
56 | DAPK3 | 0.71474748 |
57 | MAP3K11 | 0.70812490 |
58 | MAP2K1 | 0.69765191 |
59 | BRSK2 | 0.68303000 |
60 | TTK | 0.64028312 |
61 | FGR | 0.62549496 |
62 | MAP3K3 | 0.61668864 |
63 | ADRBK2 | 0.61557231 |
64 | WNK3 | 0.60170148 |
65 | RPS6KA5 | 0.58344516 |
66 | ABL2 | 0.57863261 |
67 | ERBB4 | 0.57043726 |
68 | SCYL2 | 0.56607564 |
69 | TXK | 0.49275785 |
70 | PRKCI | 0.48788233 |
71 | MOS | 0.47626307 |
72 | MAPKAPK3 | 0.43175641 |
73 | ARAF | 0.43007128 |
74 | CSNK2A2 | 0.42597698 |
75 | STK4 | 0.42381419 |
76 | LMTK2 | 0.41680276 |
77 | CDK8 | 0.41055012 |
78 | PIK3CA | 0.40425407 |
79 | MINK1 | 0.40304230 |
80 | CSNK2A1 | 0.40144053 |
81 | CHEK1 | 0.40111416 |
82 | DYRK1B | 0.37723166 |
83 | NEK6 | 0.35975839 |
84 | EPHA3 | 0.35806020 |
85 | PAK1 | 0.34257480 |
86 | UHMK1 | 0.33450781 |
87 | CSNK1G3 | 0.33407670 |
88 | CSF1R | 0.32349415 |
89 | PBK | 0.30570235 |
90 | CSNK1A1 | 0.30322688 |
91 | DYRK3 | 0.29850430 |
92 | IRAK3 | 0.29546704 |
93 | PRKACB | 0.29093506 |
94 | SRPK1 | 0.28579881 |
95 | TAOK3 | 0.28484614 |
96 | AKT2 | 0.27961833 |
97 | NEK9 | 0.27312007 |
98 | JAK3 | 0.26856631 |
99 | IKBKB | 0.26588957 |
100 | CDK1 | 0.25288005 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 3.98587899 |
2 | DNA replication_Homo sapiens_hsa03030 | 3.95813392 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.64293364 |
4 | Ribosome_Homo sapiens_hsa03010 | 3.63911136 |
5 | RNA polymerase_Homo sapiens_hsa03020 | 2.99876953 |
6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.92717265 |
7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.86479642 |
8 | Mismatch repair_Homo sapiens_hsa03430 | 2.75137925 |
9 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.67648015 |
10 | Homologous recombination_Homo sapiens_hsa03440 | 2.53429553 |
11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.50798072 |
12 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.48935523 |
13 | Spliceosome_Homo sapiens_hsa03040 | 2.45068285 |
14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.38269774 |
15 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.33220613 |
16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.10296684 |
17 | Alzheimers disease_Homo sapiens_hsa05010 | 2.10126197 |
18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.95323101 |
19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.94120441 |
20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.92628818 |
21 | Base excision repair_Homo sapiens_hsa03410 | 1.88642375 |
22 | Sulfur relay system_Homo sapiens_hsa04122 | 1.83018209 |
23 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.78711319 |
24 | RNA transport_Homo sapiens_hsa03013 | 1.69106098 |
25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.66158833 |
26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.51685716 |
27 | Protein export_Homo sapiens_hsa03060 | 1.50810498 |
28 | Cell cycle_Homo sapiens_hsa04110 | 1.48907299 |
29 | Alcoholism_Homo sapiens_hsa05034 | 1.41323209 |
30 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.34015415 |
31 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.32729702 |
32 | RNA degradation_Homo sapiens_hsa03018 | 1.30657147 |
33 | Purine metabolism_Homo sapiens_hsa00230 | 1.22647971 |
34 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.22264562 |
35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.14640061 |
36 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.14203689 |
37 | Basal transcription factors_Homo sapiens_hsa03022 | 1.12847377 |
38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.08122934 |
39 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.04041734 |
40 | Carbon metabolism_Homo sapiens_hsa01200 | 1.02765092 |
41 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.94202811 |
42 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.92959931 |
43 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.88241808 |
44 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.85367124 |
45 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.84558219 |
46 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.80149157 |
47 | Galactose metabolism_Homo sapiens_hsa00052 | 0.72280326 |
48 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.71809247 |
49 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.70731297 |
50 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68344595 |
51 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.66373515 |
52 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.65682336 |
53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.61572235 |
54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.59793907 |
55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.53082116 |
56 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.52045477 |
57 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.51910287 |
58 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.50314976 |
59 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.50178122 |
60 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.49836806 |
61 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.49446648 |
62 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.47467742 |
63 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.45841890 |
64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.45278279 |
65 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.44260905 |
66 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.43634300 |
67 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.41331470 |
68 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39769994 |
69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.38393756 |
70 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.37825899 |
71 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.37061162 |
72 | Taste transduction_Homo sapiens_hsa04742 | 0.34880183 |
73 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.34467115 |
74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.34385849 |
75 | Phototransduction_Homo sapiens_hsa04744 | 0.33779762 |
76 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.29285495 |
77 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.27712009 |
78 | Peroxisome_Homo sapiens_hsa04146 | 0.26588612 |
79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.25635169 |
80 | Thyroid cancer_Homo sapiens_hsa05216 | 0.25109366 |
81 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.24184150 |
82 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.21822668 |
83 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.21735795 |
84 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.20345721 |
85 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.18907433 |
86 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.18167258 |
87 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.16609154 |
88 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.15544749 |
89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.13955104 |
90 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.13603256 |
91 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.13094192 |
92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.12877422 |
93 | GABAergic synapse_Homo sapiens_hsa04727 | 0.12354636 |
94 | HTLV-I infection_Homo sapiens_hsa05166 | 0.12104608 |
95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.10406124 |
96 | Salivary secretion_Homo sapiens_hsa04970 | 0.09555820 |
97 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.08709728 |
98 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.07716489 |
99 | Morphine addiction_Homo sapiens_hsa05032 | 0.07585973 |
100 | Nicotine addiction_Homo sapiens_hsa05033 | 0.06239327 |