HMGN2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.05156018
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.05156018
3establishment of integrated proviral latency (GO:0075713)5.55405055
4sequestering of actin monomers (GO:0042989)5.39392088
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.18998461
6regulation of mitochondrial translation (GO:0070129)4.87392802
7folic acid-containing compound biosynthetic process (GO:0009396)4.77712998
8maturation of SSU-rRNA (GO:0030490)4.68852734
9proteasome assembly (GO:0043248)4.33187573
10establishment of viral latency (GO:0019043)4.31829234
11ribosomal large subunit biogenesis (GO:0042273)4.28652052
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.25225143
13NADH dehydrogenase complex assembly (GO:0010257)4.25225143
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25225143
15galactose catabolic process (GO:0019388)4.20374644
16ATP synthesis coupled proton transport (GO:0015986)4.14755886
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14755886
18ribosomal small subunit assembly (GO:0000028)4.10657336
19rRNA modification (GO:0000154)4.03388680
20protein complex biogenesis (GO:0070271)3.97943061
21chaperone-mediated protein transport (GO:0072321)3.96977505
22DNA strand elongation involved in DNA replication (GO:0006271)3.94236552
23DNA ligation (GO:0006266)3.92223635
24ribosome biogenesis (GO:0042254)3.92146448
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.83325264
26mitochondrial respiratory chain complex assembly (GO:0033108)3.80162754
27DNA strand elongation (GO:0022616)3.79077803
28mitochondrial RNA metabolic process (GO:0000959)3.78248414
29inner mitochondrial membrane organization (GO:0007007)3.78221257
30ribonucleoprotein complex biogenesis (GO:0022613)3.75226326
31mitotic sister chromatid segregation (GO:0000070)3.70626754
32peptidyl-histidine modification (GO:0018202)3.68530208
33telomere maintenance via semi-conservative replication (GO:0032201)3.64683142
34negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.62368334
35peptidyl-arginine omega-N-methylation (GO:0035247)3.62253096
36cellular component biogenesis (GO:0044085)3.60718953
37neurofilament cytoskeleton organization (GO:0060052)3.59689765
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.59084524
39CENP-A containing nucleosome assembly (GO:0034080)3.57220644
40purine nucleotide salvage (GO:0032261)3.54475111
41rRNA methylation (GO:0031167)3.53406784
42regulation of plasminogen activation (GO:0010755)3.51626457
43homocysteine metabolic process (GO:0050667)3.51353140
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.46875931
45termination of RNA polymerase III transcription (GO:0006386)3.46875931
46pteridine-containing compound biosynthetic process (GO:0042559)3.41412355
47neurotransmitter catabolic process (GO:0042135)3.41042827
48respiratory electron transport chain (GO:0022904)3.40786834
49chromatin remodeling at centromere (GO:0031055)3.40203236
50pseudouridine synthesis (GO:0001522)3.40145376
51galactose metabolic process (GO:0006012)3.39903572
52electron transport chain (GO:0022900)3.37356981
53histone arginine methylation (GO:0034969)3.35899419
54DNA strand renaturation (GO:0000733)3.35077987
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34851617
56viral transcription (GO:0019083)3.32842105
57DNA unwinding involved in DNA replication (GO:0006268)3.31892949
58transcription from mitochondrial promoter (GO:0006390)3.30775973
59positive regulation of endothelial cell differentiation (GO:0045603)3.30154958
60microtubule depolymerization (GO:0007019)3.25231402
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23717536
62tRNA modification (GO:0006400)3.22363065
63sister chromatid segregation (GO:0000819)3.21393910
64adenosine metabolic process (GO:0046085)3.20048507
65translational termination (GO:0006415)3.13203094
66IMP biosynthetic process (GO:0006188)3.11857800
67transcription-coupled nucleotide-excision repair (GO:0006283)3.09000074
68GMP metabolic process (GO:0046037)3.08714619
69spliceosomal snRNP assembly (GO:0000387)3.06960883
70regulation of spindle organization (GO:0090224)3.04719613
71L-serine metabolic process (GO:0006563)3.02022908
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00909274
73ribosomal small subunit biogenesis (GO:0042274)3.00874912
74DNA replication-independent nucleosome organization (GO:0034724)3.00317112
75DNA replication-independent nucleosome assembly (GO:0006336)3.00317112
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99790904
77positive regulation of amino acid transport (GO:0051957)2.99383861
78translational elongation (GO:0006414)2.98745621
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97306689
80sulfur amino acid catabolic process (GO:0000098)2.94505100
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92267704
82histone exchange (GO:0043486)2.91752173
83cotranslational protein targeting to membrane (GO:0006613)2.90970853
84epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.90861024
85tRNA processing (GO:0008033)2.89610778
86mitotic recombination (GO:0006312)2.89280150
87protein targeting to ER (GO:0045047)2.86792694
88peptidyl-arginine N-methylation (GO:0035246)2.86181854
89peptidyl-arginine methylation (GO:0018216)2.86181854
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84283608
91microtubule nucleation (GO:0007020)2.82584760
92intermediate filament organization (GO:0045109)2.81008834
93rRNA processing (GO:0006364)2.80839582
94alternative mRNA splicing, via spliceosome (GO:0000380)2.79893154
95maturation of 5.8S rRNA (GO:0000460)2.79737704
96mitotic metaphase plate congression (GO:0007080)2.79737121
97histone-serine phosphorylation (GO:0035404)2.78722394
98replication fork processing (GO:0031297)2.78544078
99V(D)J recombination (GO:0033151)2.76417159
100guanosine-containing compound biosynthetic process (GO:1901070)2.75518120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20466585
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.69933392
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.96481704
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95823761
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.89305715
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.86375861
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81786581
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.78163484
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.68960046
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.67856175
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.48710988
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43958908
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09189799
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.06053998
15ETS1_20019798_ChIP-Seq_JURKAT_Human3.02425107
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89131947
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78457665
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71253016
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67080783
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50568314
21XRN2_22483619_ChIP-Seq_HELA_Human2.50357241
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45702702
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44775419
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.37319000
25VDR_23849224_ChIP-Seq_CD4+_Human2.32723285
26ELK1_19687146_ChIP-ChIP_HELA_Human2.32493407
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12019172
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11516758
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10424468
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.02345010
31GABP_19822575_ChIP-Seq_HepG2_Human2.02100689
32FOXP3_21729870_ChIP-Seq_TREG_Human2.01588057
33TTF2_22483619_ChIP-Seq_HELA_Human2.01064586
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.97801216
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.95440509
36DCP1A_22483619_ChIP-Seq_HELA_Human1.90579915
37IRF1_19129219_ChIP-ChIP_H3396_Human1.87620987
38AR_21909140_ChIP-Seq_LNCAP_Human1.84191983
39MYC_18940864_ChIP-ChIP_HL60_Human1.77755470
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75994988
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74534785
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71928222
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67197613
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63480753
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56229443
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48624052
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47207088
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.44350538
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43625369
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.41282998
51KDM5A_27292631_Chip-Seq_BREAST_Human1.41072984
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39248021
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38369829
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35367049
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32901473
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27190417
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26818797
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25650605
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25357142
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.23242337
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21069478
62ZNF263_19887448_ChIP-Seq_K562_Human1.16690720
63SOX17_20123909_ChIP-Seq_XEN_Mouse1.13041818
64CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09658252
65ZNF274_21170338_ChIP-Seq_K562_Hela1.08748195
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08726228
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08602149
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.05096399
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04304300
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03554675
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02000588
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00544610
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99740047
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97758971
75CIITA_25753668_ChIP-Seq_RAJI_Human0.97413353
76POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92963082
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92763749
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92055290
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91964783
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91407598
81KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89693017
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89587515
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88598213
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.87332992
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84254555
86FOXP1_21924763_ChIP-Seq_HESCs_Human0.82500251
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82122087
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80830397
89CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79261444
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.78467884
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76117020
92ERG_20517297_ChIP-Seq_VCAP_Human0.74563741
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74265053
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73736145
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72580579
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70118923
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69563849
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.69288694
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69287897
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68342773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.60210726
2MP0005360_urolithiasis3.58457713
3MP0010094_abnormal_chromosome_stability3.42313265
4MP0002735_abnormal_chemical_nociception3.10511945
5MP0010030_abnormal_orbit_morphology2.97447856
6MP0008058_abnormal_DNA_repair2.94855211
7MP0002234_abnormal_pharynx_morphology2.84352003
8MP0009379_abnormal_foot_pigmentation2.51724220
9MP0003693_abnormal_embryo_hatching2.46534163
10MP0003111_abnormal_nucleus_morphology2.45955243
11MP0003806_abnormal_nucleotide_metabolis2.31734763
12MP0006292_abnormal_olfactory_placode2.15869886
13MP0002938_white_spotting2.15813232
14MP0004185_abnormal_adipocyte_glucose2.15397615
15MP0001346_abnormal_lacrimal_gland2.11162475
16MP0005075_abnormal_melanosome_morpholog2.10874745
17MP0003786_premature_aging2.08866967
18MP0000516_abnormal_urinary_system2.04551086
19MP0005367_renal/urinary_system_phenotyp2.04551086
20MP0008932_abnormal_embryonic_tissue2.04443324
21MP0009053_abnormal_anal_canal2.04006031
22MP0004957_abnormal_blastocyst_morpholog1.99433601
23MP0004381_abnormal_hair_follicle1.93475589
24MP0003077_abnormal_cell_cycle1.91979997
25MP0000647_abnormal_sebaceous_gland1.88063326
26MP0003705_abnormal_hypodermis_morpholog1.87954312
27MP0008995_early_reproductive_senescence1.86983802
28MP0002736_abnormal_nociception_after1.85612381
29MP0000013_abnormal_adipose_tissue1.70247819
30MP0008057_abnormal_DNA_replication1.67556588
31MP0003315_abnormal_perineum_morphology1.66158609
32MP0005670_abnormal_white_adipose1.65327923
33MP0000566_synostosis1.65256729
34MP0000534_abnormal_ureter_morphology1.63560188
35MP0002163_abnormal_gland_morphology1.62997456
36MP0002095_abnormal_skin_pigmentation1.56560438
37MP0005197_abnormal_uvea_morphology1.54648189
38MP0005646_abnormal_pituitary_gland1.54341310
39MP0001529_abnormal_vocalization1.50864893
40MP0002653_abnormal_ependyma_morphology1.50078298
41MP0001542_abnormal_bone_strength1.48677867
42MP0004885_abnormal_endolymph1.41548443
43MP0003119_abnormal_digestive_system1.32807995
44MP0003183_abnormal_peptide_metabolism1.31971111
45MP0005257_abnormal_intraocular_pressure1.23787527
46MP0008789_abnormal_olfactory_epithelium1.17247383
47MP0010386_abnormal_urinary_bladder1.15663974
48MP0003718_maternal_effect1.10128208
49MP0008007_abnormal_cellular_replicative1.10053037
50MP0000750_abnormal_muscle_regeneration1.08905652
51MP0001661_extended_life_span1.06431440
52MP0002282_abnormal_trachea_morphology1.03775100
53MP0000372_irregular_coat_pigmentation1.01120800
54MP0003890_abnormal_embryonic-extraembry1.00293728
55MP0000631_abnormal_neuroendocrine_gland0.99764574
56MP0006072_abnormal_retinal_apoptosis0.96505131
57MP0002396_abnormal_hematopoietic_system0.96378241
58MP0001853_heart_inflammation0.96111597
59MP0003186_abnormal_redox_activity0.95421506
60MP0003950_abnormal_plasma_membrane0.94209116
61MP0001243_abnormal_dermal_layer0.92333193
62MP0003942_abnormal_urinary_system0.89533877
63MP0006035_abnormal_mitochondrial_morpho0.88694455
64MP0001730_embryonic_growth_arrest0.88401420
65MP0009250_abnormal_appendicular_skeleto0.87259250
66MP0003191_abnormal_cellular_cholesterol0.86883379
67MP0001756_abnormal_urination0.85787662
68MP0001293_anophthalmia0.84962882
69MP0000490_abnormal_crypts_of0.84733886
70MP0002638_abnormal_pupillary_reflex0.84069318
71MP0003938_abnormal_ear_development0.81581319
72MP0000538_abnormal_urinary_bladder0.81338625
73MP0000733_abnormal_muscle_development0.80010999
74MP0004133_heterotaxia0.78419846
75MP0003943_abnormal_hepatobiliary_system0.76648328
76MP0004147_increased_porphyrin_level0.73335164
77MP0001286_abnormal_eye_development0.73048914
78MP0008775_abnormal_heart_ventricle0.71917928
79MP0005623_abnormal_meninges_morphology0.71758420
80MP0002075_abnormal_coat/hair_pigmentati0.71505961
81MP0009697_abnormal_copulation0.70695757
82MP0008873_increased_physiological_sensi0.69924973
83MP0002932_abnormal_joint_morphology0.69725943
84MP0002210_abnormal_sex_determination0.69283976
85MP0001666_abnormal_nutrient_absorption0.69282787
86MP0003136_yellow_coat_color0.69098849
87MP0000358_abnormal_cell_content/0.68539923
88MP0005551_abnormal_eye_electrophysiolog0.68019605
89MP0005408_hypopigmentation0.67688377
90MP0002085_abnormal_embryonic_tissue0.66982697
91MP0000026_abnormal_inner_ear0.64696706
92MP0001697_abnormal_embryo_size0.64685791
93MP0009333_abnormal_splenocyte_physiolog0.64557897
94MP0001727_abnormal_embryo_implantation0.63802654
95MP0005076_abnormal_cell_differentiation0.63480486
96MP0009780_abnormal_chondrocyte_physiolo0.62508741
97MP0001919_abnormal_reproductive_system0.62152935
98MP0001944_abnormal_pancreas_morphology0.61869466
99MP0005195_abnormal_posterior_eye0.61525262
100MP0002160_abnormal_reproductive_system0.61493364

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)6.51458780
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.51458780
3Abnormality of alanine metabolism (HP:0010916)6.51458780
4Ulnar claw (HP:0001178)4.65853167
5Birth length less than 3rd percentile (HP:0003561)4.60445691
6Abnormal number of erythroid precursors (HP:0012131)4.48540437
7Abnormality of cells of the erythroid lineage (HP:0012130)4.34557765
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.51149551
9Reduced subcutaneous adipose tissue (HP:0003758)3.32053124
10Reticulocytopenia (HP:0001896)3.28501225
11Increased serum lactate (HP:0002151)3.26662818
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16871530
13Segmental peripheral demyelination/remyelination (HP:0003481)2.99919532
14Hepatocellular necrosis (HP:0001404)2.94651336
15Abnormality of the fetal cardiovascular system (HP:0010948)2.93969755
16Abnormal umbilical cord blood vessels (HP:0011403)2.93969755
17Single umbilical artery (HP:0001195)2.93969755
18Mitochondrial inheritance (HP:0001427)2.85677654
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84044519
20Lipid accumulation in hepatocytes (HP:0006561)2.75156498
21Concave nail (HP:0001598)2.74680725
22Acute necrotizing encephalopathy (HP:0006965)2.72128216
23Hepatic necrosis (HP:0002605)2.71989557
24Elevated erythrocyte sedimentation rate (HP:0003565)2.70570611
25Abnormal mitochondria in muscle tissue (HP:0008316)2.68083300
26Increased serum pyruvate (HP:0003542)2.66217503
27Increased hepatocellular lipid droplets (HP:0006565)2.65247316
28Increased CSF lactate (HP:0002490)2.65137809
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.59127728
30Microglossia (HP:0000171)2.55537721
31Abnormality of glycolysis (HP:0004366)2.52660155
32Abnormality of chromosome stability (HP:0003220)2.52108841
33Chromsome breakage (HP:0040012)2.50532061
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50317995
35Acute encephalopathy (HP:0006846)2.49647716
36Meckel diverticulum (HP:0002245)2.46612652
37Generalized aminoaciduria (HP:0002909)2.45831613
38Lactic acidosis (HP:0003128)2.44262968
39Distal lower limb amyotrophy (HP:0008944)2.43753961
40Lower limb amyotrophy (HP:0007210)2.42474477
41Decreased subcutaneous fat (HP:0001002)2.40611371
42Pigmentary retinal degeneration (HP:0001146)2.40291917
43Renal cortical cysts (HP:0000803)2.38460731
44Abnormality of the preputium (HP:0100587)2.33299843
45Maternal diabetes (HP:0009800)2.32350569
46Constricted visual fields (HP:0001133)2.31660897
47Exercise intolerance (HP:0003546)2.29946242
48Anencephaly (HP:0002323)2.28396318
49Reduced antithrombin III activity (HP:0001976)2.26749880
50Progressive muscle weakness (HP:0003323)2.26450181
51Abnormality of the carotid arteries (HP:0005344)2.23746465
52Methylmalonic acidemia (HP:0002912)2.22617497
53Abnormality of serum amino acid levels (HP:0003112)2.21781106
54Abnormality of the ileum (HP:0001549)2.20997396
55Abnormality of the umbilical cord (HP:0010881)2.20193559
56Increased intramyocellular lipid droplets (HP:0012240)2.17777950
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16500733
58Congenital sensorineural hearing impairment (HP:0008527)2.16482966
59Sclerocornea (HP:0000647)2.15621051
60Poor speech (HP:0002465)2.14300270
61Breast hypoplasia (HP:0003187)2.11201534
62Macrocytic anemia (HP:0001972)2.09768969
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.09601093
64Upper limb muscle weakness (HP:0003484)2.08829459
65Abnormality of the labia minora (HP:0012880)2.05290362
66Congenital, generalized hypertrichosis (HP:0004540)2.03040270
67Renal Fanconi syndrome (HP:0001994)2.01232802
68Small intestinal stenosis (HP:0012848)2.00044336
69Duodenal stenosis (HP:0100867)2.00044336
70Increased muscle lipid content (HP:0009058)1.99942163
71High anterior hairline (HP:0009890)1.95784794
72Aplastic anemia (HP:0001915)1.95218019
73Cerebral edema (HP:0002181)1.95205522
74Bone marrow hypocellularity (HP:0005528)1.88596638
75Progressive macrocephaly (HP:0004481)1.87121834
76Triphalangeal thumb (HP:0001199)1.86377454
77Brittle hair (HP:0002299)1.83865458
78Glucose intolerance (HP:0000833)1.83451060
79Abnormalities of placenta or umbilical cord (HP:0001194)1.83408177
80Abnormality of pyrimidine metabolism (HP:0004353)1.83033207
81Aplasia/Hypoplasia of the patella (HP:0006498)1.82764378
82Pendular nystagmus (HP:0012043)1.82002607
83Severe combined immunodeficiency (HP:0004430)1.78258156
84Absent thumb (HP:0009777)1.75753530
85Duplicated collecting system (HP:0000081)1.74592905
86Severe muscular hypotonia (HP:0006829)1.74062733
87Opisthotonus (HP:0002179)1.74022350
88Methylmalonic aciduria (HP:0012120)1.73910009
89Difficulty climbing stairs (HP:0003551)1.73803361
90Exertional dyspnea (HP:0002875)1.72080573
91Prolonged neonatal jaundice (HP:0006579)1.71424828
92Patellar aplasia (HP:0006443)1.71298676
93Carpal bone hypoplasia (HP:0001498)1.71256849
94True hermaphroditism (HP:0010459)1.70829262
95Delayed CNS myelination (HP:0002188)1.68792927
96Nasolacrimal duct obstruction (HP:0000579)1.66841618
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.66525436
98Proximal placement of thumb (HP:0009623)1.66189857
99Abnormality of placental membranes (HP:0011409)1.64864288
100Amniotic constriction ring (HP:0009775)1.64864288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.85461311
2BUB14.79189463
3TESK23.21827271
4VRK13.06522508
5MAP4K23.02338241
6ACVR1B2.99286553
7CCNB12.71951942
8TLK12.69585891
9NEK12.61021476
10NME22.44485789
11NEK22.18252832
12MST42.10074540
13TESK12.09724465
14AURKA1.98334776
15TAF11.93292705
16TRIB31.75761553
17STK101.74220912
18LIMK11.58484082
19MST1R1.57238388
20KDR1.55915245
21PAK41.55198434
22AURKB1.51346743
23CDC71.39195212
24BCKDK1.29945568
25BMPR1B1.29479992
26EPHB21.28871764
27MAP2K31.26418886
28STK161.24882825
29EIF2AK11.24658159
30RPS6KB21.10554106
31SIK21.09208910
32CDK71.08441736
33SMG11.04757240
34CHEK21.03522380
35ILK1.01987417
36SIK11.01810454
37ADRBK11.00632819
38BRSK10.99729366
39PLK30.97357015
40ATR0.97100438
41NUAK10.95170127
42ZAK0.94390842
43PLK10.93854695
44TGFBR10.90764522
45PIM20.84646248
46EIF2AK20.84006427
47DAPK10.83400548
48DYRK20.80059293
49PDK20.79865667
50PLK40.79025328
51EPHA20.78479528
52WEE10.76226930
53CDK90.74596155
54MAP3K120.74523668
55PASK0.72554151
56DAPK30.71474748
57MAP3K110.70812490
58MAP2K10.69765191
59BRSK20.68303000
60TTK0.64028312
61FGR0.62549496
62MAP3K30.61668864
63ADRBK20.61557231
64WNK30.60170148
65RPS6KA50.58344516
66ABL20.57863261
67ERBB40.57043726
68SCYL20.56607564
69TXK0.49275785
70PRKCI0.48788233
71MOS0.47626307
72MAPKAPK30.43175641
73ARAF0.43007128
74CSNK2A20.42597698
75STK40.42381419
76LMTK20.41680276
77CDK80.41055012
78PIK3CA0.40425407
79MINK10.40304230
80CSNK2A10.40144053
81CHEK10.40111416
82DYRK1B0.37723166
83NEK60.35975839
84EPHA30.35806020
85PAK10.34257480
86UHMK10.33450781
87CSNK1G30.33407670
88CSF1R0.32349415
89PBK0.30570235
90CSNK1A10.30322688
91DYRK30.29850430
92IRAK30.29546704
93PRKACB0.29093506
94SRPK10.28579881
95TAOK30.28484614
96AKT20.27961833
97NEK90.27312007
98JAK30.26856631
99IKBKB0.26588957
100CDK10.25288005

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98587899
2DNA replication_Homo sapiens_hsa030303.95813392
3Oxidative phosphorylation_Homo sapiens_hsa001903.64293364
4Ribosome_Homo sapiens_hsa030103.63911136
5RNA polymerase_Homo sapiens_hsa030202.99876953
6Parkinsons disease_Homo sapiens_hsa050122.92717265
7One carbon pool by folate_Homo sapiens_hsa006702.86479642
8Mismatch repair_Homo sapiens_hsa034302.75137925
9Non-homologous end-joining_Homo sapiens_hsa034502.67648015
10Homologous recombination_Homo sapiens_hsa034402.53429553
11Nucleotide excision repair_Homo sapiens_hsa034202.50798072
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48935523
13Spliceosome_Homo sapiens_hsa030402.45068285
14Huntingtons disease_Homo sapiens_hsa050162.38269774
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33220613
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10296684
17Alzheimers disease_Homo sapiens_hsa050102.10126197
18Pyrimidine metabolism_Homo sapiens_hsa002401.95323101
19Fanconi anemia pathway_Homo sapiens_hsa034601.94120441
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92628818
21Base excision repair_Homo sapiens_hsa034101.88642375
22Sulfur relay system_Homo sapiens_hsa041221.83018209
23Systemic lupus erythematosus_Homo sapiens_hsa053221.78711319
24RNA transport_Homo sapiens_hsa030131.69106098
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66158833
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51685716
27Protein export_Homo sapiens_hsa030601.50810498
28Cell cycle_Homo sapiens_hsa041101.48907299
29Alcoholism_Homo sapiens_hsa050341.41323209
30Biosynthesis of amino acids_Homo sapiens_hsa012301.34015415
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32729702
32RNA degradation_Homo sapiens_hsa030181.30657147
33Purine metabolism_Homo sapiens_hsa002301.22647971
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22264562
35Pyruvate metabolism_Homo sapiens_hsa006201.14640061
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.14203689
37Basal transcription factors_Homo sapiens_hsa030221.12847377
38Cardiac muscle contraction_Homo sapiens_hsa042601.08122934
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.04041734
40Carbon metabolism_Homo sapiens_hsa012001.02765092
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94202811
42Folate biosynthesis_Homo sapiens_hsa007900.92959931
43Propanoate metabolism_Homo sapiens_hsa006400.88241808
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.85367124
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84558219
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80149157
47Galactose metabolism_Homo sapiens_hsa000520.72280326
48Sulfur metabolism_Homo sapiens_hsa009200.71809247
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70731297
50Metabolic pathways_Homo sapiens_hsa011000.68344595
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.66373515
52Arginine biosynthesis_Homo sapiens_hsa002200.65682336
53mRNA surveillance pathway_Homo sapiens_hsa030150.61572235
54Fatty acid elongation_Homo sapiens_hsa000620.59793907
55Steroid biosynthesis_Homo sapiens_hsa001000.53082116
56Basal cell carcinoma_Homo sapiens_hsa052170.52045477
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51910287
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50314976
59Pentose phosphate pathway_Homo sapiens_hsa000300.50178122
60Nitrogen metabolism_Homo sapiens_hsa009100.49836806
61Epstein-Barr virus infection_Homo sapiens_hsa051690.49446648
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47467742
63Viral carcinogenesis_Homo sapiens_hsa052030.45841890
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45278279
65Vitamin digestion and absorption_Homo sapiens_hsa049770.44260905
66Collecting duct acid secretion_Homo sapiens_hsa049660.43634300
67Vibrio cholerae infection_Homo sapiens_hsa051100.41331470
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39769994
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38393756
70TGF-beta signaling pathway_Homo sapiens_hsa043500.37825899
71Selenocompound metabolism_Homo sapiens_hsa004500.37061162
72Taste transduction_Homo sapiens_hsa047420.34880183
73Butanoate metabolism_Homo sapiens_hsa006500.34467115
74Glutathione metabolism_Homo sapiens_hsa004800.34385849
75Phototransduction_Homo sapiens_hsa047440.33779762
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29285495
77p53 signaling pathway_Homo sapiens_hsa041150.27712009
78Peroxisome_Homo sapiens_hsa041460.26588612
79Oocyte meiosis_Homo sapiens_hsa041140.25635169
80Thyroid cancer_Homo sapiens_hsa052160.25109366
81Hippo signaling pathway_Homo sapiens_hsa043900.24184150
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21822668
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21735795
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20345721
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18907433
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18167258
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.16609154
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15544749
89Arginine and proline metabolism_Homo sapiens_hsa003300.13955104
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13603256
91Renin-angiotensin system_Homo sapiens_hsa046140.13094192
92Regulation of autophagy_Homo sapiens_hsa041400.12877422
93GABAergic synapse_Homo sapiens_hsa047270.12354636
94HTLV-I infection_Homo sapiens_hsa051660.12104608
95N-Glycan biosynthesis_Homo sapiens_hsa005100.10406124
96Salivary secretion_Homo sapiens_hsa049700.09555820
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08709728
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07716489
99Morphine addiction_Homo sapiens_hsa050320.07585973
100Nicotine addiction_Homo sapiens_hsa050330.06239327

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