ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.78746124
2	DNA deamination (GO:0045006)	8.57191031
3	cytidine deamination (GO:0009972)	8.38805488
4	cytidine metabolic process (GO:0046087)	8.38805488
5	cytidine catabolic process (GO:0006216)	8.38805488
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.28751945
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	6.10687385
8	actin nucleation (GO:0045010)	5.40030828
9	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.37183665
10	sequestering of actin monomers (GO:0042989)	5.17833874
11	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	5.03308136
12	regulation of B cell receptor signaling pathway (GO:0050855)	4.74727535
13	macrophage chemotaxis (GO:0048246)	4.68029967
14	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.54713312
15	cytolysis (GO:0019835)	4.46245455
16	negative regulation of T cell apoptotic process (GO:0070233)	4.45428412
17	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.44188728
18	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.30684925
19	deoxyribose phosphate biosynthetic process (GO:0046385)	4.30600859
20	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.30600859
21	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	4.29220344
22	negative regulation by host of viral transcription (GO:0043922)	4.15360294
23	deoxyribonucleotide biosynthetic process (GO:0009263)	4.14550982
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.07375280
25	eosinophil chemotaxis (GO:0048245)	3.95214451
26	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.91091051
27	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.77000755
28	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.76644288
29	regulation of cellular amino acid metabolic process (GO:0006521)	3.74097204
30	respiratory electron transport chain (GO:0022904)	3.72124041
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.70144303
32	ATP synthesis coupled proton transport (GO:0015986)	3.70144303
33	regulation of activation of Janus kinase activity (GO:0010533)	3.68611055
34	regulation of T cell receptor signaling pathway (GO:0050856)	3.68124639
35	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.66352585
36	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.66352585
37	electron transport chain (GO:0022900)	3.65230167
38	purine deoxyribonucleotide metabolic process (GO:0009151)	3.64865913
39	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.63274123
40	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.63274123
41	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.63274123
42	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.61761226
43	purine deoxyribonucleotide catabolic process (GO:0009155)	3.59077524
44	negative regulation of viral genome replication (GO:0045071)	3.58880417
45	eosinophil migration (GO:0072677)	3.57847509
46	positive regulation of T cell apoptotic process (GO:0070234)	3.56520296
47	regulation of natural killer cell mediated immunity (GO:0002715)	3.56308399
48	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.56308399
49	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.54328033
50	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.48925456
51	pyrimidine nucleoside catabolic process (GO:0046135)	3.47453838
52	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.44401128
53	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.44401128
54	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	3.44211722
55	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.43854396
56	negative regulation of oxidoreductase activity (GO:0051354)	3.43737150
57	positive regulation of lamellipodium assembly (GO:0010592)	3.43007146
58	positive regulation of translational initiation (GO:0045948)	3.41731161
59	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.40622227
60	positive T cell selection (GO:0043368)	3.40585435
61	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.36845830
62	negative regulation of ligase activity (GO:0051352)	3.36845830
63	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.34203401
64	negative regulation of execution phase of apoptosis (GO:1900118)	3.30367828
65	cellular response to interleukin-15 (GO:0071350)	3.29422360
66	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.28405768
67	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.26159147
68	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.25496759
69	positive regulation of calcium-mediated signaling (GO:0050850)	3.24285326
70	2-deoxyribonucleotide metabolic process (GO:0009394)	3.23136196
71	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.22448060
72	regulation of T cell apoptotic process (GO:0070232)	3.17799370
73	regulation of chronic inflammatory response (GO:0002676)	3.12511032
74	positive regulation of interleukin-8 secretion (GO:2000484)	3.09755427
75	T cell migration (GO:0072678)	3.09300373
76	deoxyribonucleotide catabolic process (GO:0009264)	3.09241900
77	deoxyribonucleotide metabolic process (GO:0009262)	3.08826692
78	deoxyribose phosphate metabolic process (GO:0019692)	3.08303780
79	positive regulation of cell cycle arrest (GO:0071158)	3.07466135
80	negative T cell selection (GO:0043383)	3.07307066
81	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.04941316
82	rRNA modification (GO:0000154)	3.03166688
83	deoxyribose phosphate catabolic process (GO:0046386)	2.98876966
84	cellular response to interferon-beta (GO:0035458)	2.95159602
85	signal peptide processing (GO:0006465)	2.93348846
86	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.93181297
87	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.93172998
88	purine nucleotide salvage (GO:0032261)	2.92040509
89	positive thymic T cell selection (GO:0045059)	2.91937125
90	response to interferon-beta (GO:0035456)	2.90099222
91	ubiquinone biosynthetic process (GO:0006744)	2.87596089
92	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.86314199
93	protein maturation by protein folding (GO:0022417)	2.84635327
94	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.82562142
95	rRNA methylation (GO:0031167)	2.81845328
96	positive regulation of cell killing (GO:0031343)	2.80359040
97	positive regulation of defense response to virus by host (GO:0002230)	2.80024015
98	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.79785288
99	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.77082450
100	positive regulation of ligase activity (GO:0051351)	2.75794929

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.75133680
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.01834637
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.81047792
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.09238702
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.69137562
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.59672961
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.47215437
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.34982510
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.85154548
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.79200089
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.71339261
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.60306722
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58802598
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.49914152
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.46754324
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.41993896
17	MYB_26560356_Chip-Seq_TH2_Human	2.31473173
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.19788457
19	VDR_22108803_ChIP-Seq_LS180_Human	2.17330480
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05627861
21	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.99832462
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96905373
23	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.94652450
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.91074176
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83013547
26	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.79438929
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79195224
28	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.73262381
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.72371995
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69611558
31	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.69129372
32	GATA3_27048872_Chip-Seq_THYMUS_Human	1.65653843
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.65268328
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.60209469
35	HTT_18923047_ChIP-ChIP_STHdh_Human	1.57777652
36	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.57654614
37	GATA3_26560356_Chip-Seq_TH2_Human	1.55125467
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54425816
39	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.46363907
40	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.44623155
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42269994
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.41795059
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.41711677
44	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.39636531
45	ERG_20517297_ChIP-Seq_VCAP_Human	1.37879357
46	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37580142
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32403917
48	MYB_26560356_Chip-Seq_TH1_Human	1.31499749
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.31000602
50	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.30516658
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28927583
52	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28295030
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.28212224
54	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.24742249
55	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19628127
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.19547741
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.17925983
58	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.17656737
59	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.16530055
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.16139730
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15620774
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.15153238
63	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.14659450
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.14021533
65	RUNX_20019798_ChIP-Seq_JUKART_Human	1.12580916
66	ZNF274_21170338_ChIP-Seq_K562_Hela	1.11403240
67	UTX_26944678_Chip-Seq_JUKART_Human	1.10936169
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.09185689
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07218155
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07148363
71	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.05484197
72	AR_20517297_ChIP-Seq_VCAP_Human	1.00572517
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00072786
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97539848
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97539848
76	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97204171
77	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.95517309
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95176966
79	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94865835
80	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.93408191
81	P300_27268052_Chip-Seq_Bcells_Human	0.93216353
82	NCOR_22424771_ChIP-Seq_293T_Human	0.93168643
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.93114599
84	GABP_19822575_ChIP-Seq_HepG2_Human	0.92819543
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91177661
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91177661
87	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.90920003
88	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.90282139
89	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.89435183
90	MAF_26560356_Chip-Seq_TH2_Human	0.89091422
91	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88945576
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88938236
93	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.87302311
94	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86989375
95	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.86633116
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.86577536
97	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.86500248
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86484235
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85100539
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.84810978

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.57589804
2	MP0009785_altered_susceptibility_to	3.58455649
3	MP0009333_abnormal_splenocyte_physiolog	3.29723572
4	MP0003763_abnormal_thymus_physiology	3.13868968
5	MP0002166_altered_tumor_susceptibility	2.76761767
6	MP0003806_abnormal_nucleotide_metabolis	2.71994106
7	MP0006082_CNS_inflammation	2.69547179
8	MP0005451_abnormal_body_composition	2.68538134
9	MP0001835_abnormal_antigen_presentation	2.56391917
10	MP0005000_abnormal_immune_tolerance	2.42836787
11	MP0002653_abnormal_ependyma_morphology	2.39049068
12	MP0002006_tumorigenesis	2.38221938
13	MP0005379_endocrine/exocrine_gland_phen	2.18351590
14	MP0005387_immune_system_phenotype	2.16776880
15	MP0001790_abnormal_immune_system	2.16776880
16	MP0001800_abnormal_humoral_immune	2.13957924
17	MP0005025_abnormal_response_to	2.07674362
18	MP0002420_abnormal_adaptive_immunity	2.03684292
19	MP0001819_abnormal_immune_cell	1.95912415
20	MP0002723_abnormal_immune_serum	1.92330763
21	MP0001873_stomach_inflammation	1.89111707
22	MP0002163_abnormal_gland_morphology	1.85202493
23	MP0002148_abnormal_hypersensitivity_rea	1.81834478
24	MP0003252_abnormal_bile_duct	1.81182030
25	MP0003283_abnormal_digestive_organ	1.78920175
26	MP0009697_abnormal_copulation	1.77401990
27	MP0000685_abnormal_immune_system	1.75124376
28	MP0004147_increased_porphyrin_level	1.74975874
29	MP0010386_abnormal_urinary_bladder	1.74437039
30	MP0003786_premature_aging	1.70792049
31	MP0003448_altered_tumor_morphology	1.69644527
32	MP0002452_abnormal_antigen_presenting	1.68005820
33	MP0003866_abnormal_defecation	1.66803690
34	MP0002405_respiratory_system_inflammati	1.64638387
35	MP0001485_abnormal_pinna_reflex	1.62044346
36	MP0002933_joint_inflammation	1.54524963
37	MP0002876_abnormal_thyroid_physiology	1.54412113
38	MP0005084_abnormal_gallbladder_morpholo	1.51815723
39	MP0006036_abnormal_mitochondrial_physio	1.45875725
40	MP0000716_abnormal_immune_system	1.45523509
41	MP0001845_abnormal_inflammatory_respons	1.44145738
42	MP0002398_abnormal_bone_marrow	1.43993727
43	MP0005645_abnormal_hypothalamus_physiol	1.43791852
44	MP0002160_abnormal_reproductive_system	1.39933062
45	MP0002234_abnormal_pharynx_morphology	1.39541469
46	MP0005551_abnormal_eye_electrophysiolog	1.38417940
47	MP0004145_abnormal_muscle_electrophysio	1.36384745
48	MP0000689_abnormal_spleen_morphology	1.34666570
49	MP0002736_abnormal_nociception_after	1.34404704
50	MP0006072_abnormal_retinal_apoptosis	1.33091003
51	MP0000703_abnormal_thymus_morphology	1.30903215
52	MP0002722_abnormal_immune_system	1.30195644
53	MP0001968_abnormal_touch/_nociception	1.27503935
54	MP0005389_reproductive_system_phenotype	1.21244823
55	MP0010094_abnormal_chromosome_stability	1.17746820
56	MP0002429_abnormal_blood_cell	1.17018963
57	MP0006035_abnormal_mitochondrial_morpho	1.15801719
58	MP0002419_abnormal_innate_immunity	1.14122581
59	MP0001919_abnormal_reproductive_system	1.13627196
60	MP0001905_abnormal_dopamine_level	1.09539226
61	MP0002837_dystrophic_cardiac_calcinosis	1.09411836
62	MP0008875_abnormal_xenobiotic_pharmacok	1.08585480
63	MP0001661_extended_life_span	1.08540559
64	MP0004957_abnormal_blastocyst_morpholog	1.08353973
65	MP0000372_irregular_coat_pigmentation	1.05268684
66	MP0002693_abnormal_pancreas_physiology	1.01892268
67	MP0005075_abnormal_melanosome_morpholog	1.00710569
68	MP0001501_abnormal_sleep_pattern	0.99604291
69	MP0003567_abnormal_fetal_cardiomyocyte	0.92970240
70	MP0003045_fibrosis	0.91493032
71	MP0003436_decreased_susceptibility_to	0.91264213
72	MP0010155_abnormal_intestine_physiology	0.90168530
73	MP0005083_abnormal_biliary_tract	0.89986634
74	MP0003137_abnormal_impulse_conducting	0.89378916
75	MP0008469_abnormal_protein_level	0.88513708
76	MP0005377_hearing/vestibular/ear_phenot	0.87317775
77	MP0003878_abnormal_ear_physiology	0.87317775
78	MP0008260_abnormal_autophagy	0.86388524
79	MP0001666_abnormal_nutrient_absorption	0.82205408
80	MP0001188_hyperpigmentation	0.80791478
81	MP0006292_abnormal_olfactory_placode	0.79581843
82	MP0005360_urolithiasis	0.76776177
83	MP0008872_abnormal_physiological_respon	0.76187670
84	MP0005464_abnormal_platelet_physiology	0.75022814
85	MP0009763_increased_sensitivity_to	0.74888352
86	MP0002019_abnormal_tumor_incidence	0.74126954
87	MP0001986_abnormal_taste_sensitivity	0.72795212
88	MP0002909_abnormal_adrenal_gland	0.72668170
89	MP0005636_abnormal_mineral_homeostasis	0.71567925
90	MP0003646_muscle_fatigue	0.70188191
91	MP0000639_abnormal_adrenal_gland	0.69050898
92	MP0008058_abnormal_DNA_repair	0.68593511
93	MP0004947_skin_inflammation	0.67016174
94	MP0004742_abnormal_vestibular_system	0.66095493
95	MP0002102_abnormal_ear_morphology	0.65588813
96	MP0000678_abnormal_parathyroid_gland	0.62884002
97	MP0009643_abnormal_urine_homeostasis	0.61706030
98	MP0008932_abnormal_embryonic_tissue	0.60645049
99	MP0001853_heart_inflammation	0.58674199
100	MP0002136_abnormal_kidney_physiology	0.58192290

Predicted human phenotypes

Rank	Gene Set	Z-score
1	B lymphocytopenia (HP:0010976)	5.80824794
2	Increased IgM level (HP:0003496)	5.39841579
3	Abnormality of B cell number (HP:0010975)	5.27603989
4	T lymphocytopenia (HP:0005403)	5.20947788
5	Aplastic anemia (HP:0001915)	5.02134049
6	Severe combined immunodeficiency (HP:0004430)	5.02052007
7	Abnormality of T cell number (HP:0011839)	4.80108028
8	Elevated erythrocyte sedimentation rate (HP:0003565)	4.51519890
9	Combined immunodeficiency (HP:0005387)	4.28134622
10	IgG deficiency (HP:0004315)	4.22391402
11	Autoimmune hemolytic anemia (HP:0001890)	3.98734757
12	Thyroiditis (HP:0100646)	3.89318681
13	Hepatocellular necrosis (HP:0001404)	3.84521245
14	Mitochondrial inheritance (HP:0001427)	3.81204159
15	Hepatic necrosis (HP:0002605)	3.77130820
16	Autoimmune thrombocytopenia (HP:0001973)	3.63319809
17	Acute hepatic failure (HP:0006554)	3.60916333
18	Pancytopenia (HP:0001876)	3.56409204
19	Acute necrotizing encephalopathy (HP:0006965)	3.41098580
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.40163091
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.40163091
22	Abnormal mitochondria in muscle tissue (HP:0008316)	3.33784838
23	Chronic diarrhea (HP:0002028)	3.25317026
24	Increased hepatocellular lipid droplets (HP:0006565)	3.24133256
25	Abnormality of T cells (HP:0002843)	3.16398048
26	Generalized aminoaciduria (HP:0002909)	3.11313184
27	Lipid accumulation in hepatocytes (HP:0006561)	3.11028559
28	Increased CSF lactate (HP:0002490)	3.10225886
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.03961439
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.02406310
31	Increased intramyocellular lipid droplets (HP:0012240)	3.01520072
32	Abolished electroretinogram (ERG) (HP:0000550)	2.95206720
33	3-Methylglutaconic aciduria (HP:0003535)	2.89518034
34	Encephalitis (HP:0002383)	2.77195662
35	Attenuation of retinal blood vessels (HP:0007843)	2.76740975
36	Lymphopenia (HP:0001888)	2.72905389
37	Acute encephalopathy (HP:0006846)	2.72159687
38	Hypergammaglobulinemia (HP:0010702)	2.71913615
39	Hypoproteinemia (HP:0003075)	2.71609061
40	Progressive macrocephaly (HP:0004481)	2.70091638
41	Increased muscle lipid content (HP:0009058)	2.64734595
42	Abnormality of eosinophils (HP:0001879)	2.63947004
43	Amyotrophic lateral sclerosis (HP:0007354)	2.55474613
44	Renal Fanconi syndrome (HP:0001994)	2.52750677
45	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.48934574
46	Stomatitis (HP:0010280)	2.46378754
47	Increased serum lactate (HP:0002151)	2.44761070
48	Clubbing of toes (HP:0100760)	2.41624491
49	Abnormality of the renal collecting system (HP:0004742)	2.41255032
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.38191696
51	Abnormality of the prostate (HP:0008775)	2.37794588
52	IgM deficiency (HP:0002850)	2.37783962
53	Optic disc pallor (HP:0000543)	2.36175642
54	Decreased central vision (HP:0007663)	2.34545569
55	Eosinophilia (HP:0001880)	2.27602494
56	Recurrent bronchitis (HP:0002837)	2.25329751
57	Lactic acidosis (HP:0003128)	2.23392784
58	Duplicated collecting system (HP:0000081)	2.23171820
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.22646713
60	Cerebral edema (HP:0002181)	2.22060395
61	Recurrent viral infections (HP:0004429)	2.19339277
62	Respiratory failure (HP:0002878)	2.19012631
63	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.14719346
64	Abnormality of the ileum (HP:0001549)	2.14455189
65	Joint swelling (HP:0001386)	2.13841376
66	Lymphoma (HP:0002665)	2.13739743
67	Meckel diverticulum (HP:0002245)	2.12179297
68	Exertional dyspnea (HP:0002875)	2.11688274
69	Hypoplasia of the thymus (HP:0000778)	2.08875343
70	Colon cancer (HP:0003003)	2.08039807
71	Retinal dysplasia (HP:0007973)	2.07948526
72	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04583592
73	Keratoconus (HP:0000563)	1.99828124
74	Increased corneal curvature (HP:0100692)	1.99828124
75	Abnormality of macrophages (HP:0004311)	1.98240525
76	Glycosuria (HP:0003076)	1.97850831
77	Abnormality of urine glucose concentration (HP:0011016)	1.97850831
78	Granulocytopenia (HP:0001913)	1.97386348
79	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.96703894
80	Absent thumb (HP:0009777)	1.95251397
81	Cerebral palsy (HP:0100021)	1.92498934
82	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.92381431
83	Dicarboxylic aciduria (HP:0003215)	1.92381431
84	Methylmalonic acidemia (HP:0002912)	1.88224855
85	Leukocytosis (HP:0001974)	1.87006610
86	Meningitis (HP:0001287)	1.86397532
87	Gastrointestinal infarctions (HP:0005244)	1.84355233
88	CNS demyelination (HP:0007305)	1.84226813
89	Pendular nystagmus (HP:0012043)	1.80921466
90	Recurrent fungal infections (HP:0002841)	1.80560193
91	Chromsome breakage (HP:0040012)	1.79422647
92	Cellular immunodeficiency (HP:0005374)	1.78825484
93	Chronic mucocutaneous candidiasis (HP:0002728)	1.78667344
94	Recurrent cutaneous fungal infections (HP:0011370)	1.78667344
95	Abnormality of the preputium (HP:0100587)	1.77668378
96	Episodic fever (HP:0001954)	1.76594873
97	Congenital stationary night blindness (HP:0007642)	1.76482907
98	Erythema (HP:0010783)	1.74211734
99	Bronchitis (HP:0012387)	1.71413158
100	Renal cortical cysts (HP:0000803)	1.70824141

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	6.45368911
2	TESK2	5.63282404
3	MAP3K12	3.33301419
4	VRK2	2.78784178
5	TESK1	2.78455909
6	LIMK1	2.49200186
7	BCKDK	2.48789775
8	BUB1	2.46046491
9	TXK	2.30499510
10	TAOK3	2.24404504
11	ITK	2.22168709
12	STK16	2.16314951
13	WNK4	2.11224727
14	MAP3K11	2.04711819
15	ZAK	1.86775488
16	MAP4K1	1.85698987
17	EIF2AK3	1.76561485
18	NUAK1	1.67612950
19	MAP4K2	1.62072140
20	DAPK1	1.55457077
21	ADRBK2	1.55131621
22	MST4	1.50383667
23	PINK1	1.48952577
24	VRK1	1.47980742
25	TLK1	1.45411482
26	TAF1	1.44079151
27	TEC	1.39410490
28	IKBKE	1.38155276
29	PRKCQ	1.31372778
30	STK39	1.20432414
31	BLK	1.12687644
32	EIF2AK1	1.11977366
33	NEK1	1.07640201
34	SYK	1.04223325
35	GRK1	1.04188784
36	RPS6KA4	1.02768778
37	BCR	1.02029189
38	ZAP70	1.01139655
39	MAPKAPK3	0.90562984
40	GRK7	0.84414336
41	MYLK	0.82693182
42	CDK8	0.82171538
43	WEE1	0.76505120
44	TBK1	0.76217074
45	GRK5	0.75528041
46	LCK	0.73872314
47	FES	0.72096909
48	CSF1R	0.70839554
49	PIK3CA	0.70312245
50	CAMKK2	0.66721441
51	CSK	0.66714991
52	RPS6KA5	0.66287127
53	FRK	0.65131670
54	OXSR1	0.62762093
55	BTK	0.61258246
56	ERBB3	0.61232974
57	DYRK2	0.61212745
58	BMPR1B	0.59088329
59	AURKA	0.57391290
60	CSNK1G3	0.54730026
61	LYN	0.54289332
62	WNK3	0.53300332
63	TRPM7	0.52942895
64	KIT	0.49671703
65	TNK2	0.49603149
66	PLK4	0.47246673
67	INSRR	0.44745052
68	CDC7	0.43850592
69	DAPK2	0.43343853
70	NME1	0.43048618
71	PRKD3	0.42954182
72	EIF2AK2	0.40596681
73	CLK1	0.39890521
74	CSNK1A1L	0.39870746
75	ROCK1	0.39157590
76	CSNK1A1	0.39059084
77	AURKB	0.38037110
78	PAK1	0.36109928
79	TRIM28	0.35607110
80	CSNK2A1	0.35062107
81	ATR	0.34683467
82	PIK3CG	0.34607657
83	MAPKAPK2	0.32602605
84	AKT3	0.32326352
85	CDK7	0.32319105
86	PLK1	0.32068577
87	MUSK	0.31886932
88	CDK18	0.29818379
89	CSNK1G1	0.29381231
90	SMG1	0.29096713
91	PRKCA	0.28799094
92	DAPK3	0.27840121
93	CDK15	0.27478824
94	PASK	0.27260586
95	IKBKB	0.26457422
96	FLT3	0.26298740
97	TIE1	0.25143583
98	CDK14	0.24696896
99	OBSCN	0.24669103
100	STK10	0.24227920

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.29421288
2	Primary immunodeficiency_Homo sapiens_hsa05340	5.15853974
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.60991761
4	Parkinsons disease_Homo sapiens_hsa05012	3.25642345
5	Protein export_Homo sapiens_hsa03060	2.96888370
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.78044681
7	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.59244166
8	DNA replication_Homo sapiens_hsa03030	2.50731912
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.48499494
10	Mismatch repair_Homo sapiens_hsa03430	2.10469734
11	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.10315157
12	Alzheimers disease_Homo sapiens_hsa05010	2.09368277
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.06806227
14	Allograft rejection_Homo sapiens_hsa05330	2.02483808
15	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.96111466
16	RNA polymerase_Homo sapiens_hsa03020	1.88234294
17	Huntingtons disease_Homo sapiens_hsa05016	1.88064449
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.80578124
19	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.74427176
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.69111381
21	Homologous recombination_Homo sapiens_hsa03440	1.58098782
22	Phototransduction_Homo sapiens_hsa04744	1.50446172
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46875215
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42018615
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.40300190
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30211895
27	One carbon pool by folate_Homo sapiens_hsa00670	1.30170243
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.25572888
29	Measles_Homo sapiens_hsa05162	1.24416283
30	Shigellosis_Homo sapiens_hsa05131	1.21259954
31	Ribosome_Homo sapiens_hsa03010	1.20290691
32	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.18951977
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18613346
34	Folate biosynthesis_Homo sapiens_hsa00790	1.15688135
35	Purine metabolism_Homo sapiens_hsa00230	1.05295290
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04521981
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01358355
38	Rheumatoid arthritis_Homo sapiens_hsa05323	0.93980744
39	Nucleotide excision repair_Homo sapiens_hsa03420	0.91264391
40	Non-homologous end-joining_Homo sapiens_hsa03450	0.90306604
41	Propanoate metabolism_Homo sapiens_hsa00640	0.86166386
42	Base excision repair_Homo sapiens_hsa03410	0.85603434
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.82764924
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.78415160
45	RNA degradation_Homo sapiens_hsa03018	0.77414946
46	Salmonella infection_Homo sapiens_hsa05132	0.77144479
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76503450
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76115862
49	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70145125
50	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.65606979
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65431478
52	Peroxisome_Homo sapiens_hsa04146	0.64520052
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.64114378
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63432483
55	Fatty acid elongation_Homo sapiens_hsa00062	0.62296461
56	Butanoate metabolism_Homo sapiens_hsa00650	0.61134489
57	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.60628255
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58551592
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58478734
60	Spliceosome_Homo sapiens_hsa03040	0.57916645
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56630479
62	Viral myocarditis_Homo sapiens_hsa05416	0.54354942
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.52891872
64	Glutathione metabolism_Homo sapiens_hsa00480	0.51715755
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.51681943
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50742944
67	Fatty acid degradation_Homo sapiens_hsa00071	0.49063875
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47465799
69	Herpes simplex infection_Homo sapiens_hsa05168	0.47394095
70	Metabolic pathways_Homo sapiens_hsa01100	0.46384944
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.46092944
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43856499
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43520084
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43354580
75	Asthma_Homo sapiens_hsa05310	0.37264270
76	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.35983051
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35460343
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35030850
79	Legionellosis_Homo sapiens_hsa05134	0.34510487
80	Mineral absorption_Homo sapiens_hsa04978	0.33912987
81	Sulfur metabolism_Homo sapiens_hsa00920	0.32945706
82	Regulation of autophagy_Homo sapiens_hsa04140	0.31363325
83	Olfactory transduction_Homo sapiens_hsa04740	0.30911007
84	Malaria_Homo sapiens_hsa05144	0.30351449
85	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.28854389
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.28849819
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.26937398
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26594053
89	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.26100379
90	RNA transport_Homo sapiens_hsa03013	0.25774640
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.24801194
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.24417472
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.23036647
94	Basal transcription factors_Homo sapiens_hsa03022	0.23005336
95	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.21532380
96	Apoptosis_Homo sapiens_hsa04210	0.19946714
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.19116158
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.16517340
99	Nitrogen metabolism_Homo sapiens_hsa00910	0.16362853
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.16359953

HMGN2P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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