ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	Arp2/3 complex-mediated actin nucleation (GO:0034314)	6.73457797
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.63918630
3	actin nucleation (GO:0045010)	5.87411166
4	cytidine metabolic process (GO:0046087)	5.44885584
5	cytidine catabolic process (GO:0006216)	5.44885584
6	cytidine deamination (GO:0009972)	5.44885584
7	DNA deamination (GO:0045006)	5.40817534
8	sequestering of actin monomers (GO:0042989)	5.14915994
9	regulation of B cell receptor signaling pathway (GO:0050855)	4.96980808
10	gonadal mesoderm development (GO:0007506)	4.76900381
11	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.74117996
12	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	4.65210667
13	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.64126078
14	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.42781196
15	cytolysis (GO:0019835)	4.27913766
16	deoxyribose phosphate biosynthetic process (GO:0046385)	4.27574630
17	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.27574630
18	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.26685923
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.25914641
20	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.22663102
21	negative regulation by host of viral transcription (GO:0043922)	4.17918153
22	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.99631114
23	negative regulation of stress fiber assembly (GO:0051497)	3.93840573
24	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.92966404
25	regulation of cellular amino acid metabolic process (GO:0006521)	3.92724330
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.88601633
27	ATP synthesis coupled proton transport (GO:0015986)	3.88601633
28	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.88505990
29	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.87431030
30	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.87431030
31	negative regulation of ligase activity (GO:0051352)	3.87328235
32	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.87328235
33	protein maturation by protein folding (GO:0022417)	3.85140865
34	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.84718429
35	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.84718429
36	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.84718429
37	respiratory electron transport chain (GO:0022904)	3.81350137
38	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.75034096
39	electron transport chain (GO:0022900)	3.73618392
40	regulation of natural killer cell mediated immunity (GO:0002715)	3.69849646
41	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.69849646
42	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.68399853
43	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.68399853
44	positive regulation of lamellipodium assembly (GO:0010592)	3.67803771
45	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.67264838
46	macrophage chemotaxis (GO:0048246)	3.67203707
47	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.67180819
48	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.62854424
49	deoxyribonucleotide biosynthetic process (GO:0009263)	3.60284016
50	piRNA metabolic process (GO:0034587)	3.58195797
51	negative regulation of T cell differentiation in thymus (GO:0033085)	3.53232558
52	histone H2A acetylation (GO:0043968)	3.52263816
53	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.42702675
54	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.38429171
55	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.38197554
56	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	3.36852996
57	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.28915209
58	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.23277105
59	ubiquinone biosynthetic process (GO:0006744)	3.23057363
60	positive thymic T cell selection (GO:0045059)	3.22346117
61	positive regulation of T cell apoptotic process (GO:0070234)	3.19272471
62	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.16616832
63	DNA ligation (GO:0006266)	3.14855603
64	negative regulation of oxidoreductase activity (GO:0051354)	3.14673486
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.14451987
66	positive regulation of ligase activity (GO:0051351)	3.13639926
67	positive regulation of cell cycle arrest (GO:0071158)	3.12132803
68	2-deoxyribonucleotide metabolic process (GO:0009394)	3.07543236
69	CENP-A containing nucleosome assembly (GO:0034080)	3.06882210
70	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.04979766
71	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.04960262
72	negative regulation of cell fate specification (GO:0009996)	3.02839466
73	ubiquinone metabolic process (GO:0006743)	3.02548681
74	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.00492541
75	iron-sulfur cluster assembly (GO:0016226)	2.99327845
76	metallo-sulfur cluster assembly (GO:0031163)	2.99327845
77	positive regulation of lamellipodium organization (GO:1902745)	2.97522795
78	regulation of cellular amine metabolic process (GO:0033238)	2.97298097
79	execution phase of apoptosis (GO:0097194)	2.97017411
80	purine deoxyribonucleotide catabolic process (GO:0009155)	2.96758800
81	negative regulation of actin filament bundle assembly (GO:0032232)	2.95875029
82	mechanosensory behavior (GO:0007638)	2.95424157
83	mismatch repair (GO:0006298)	2.95193834
84	chromatin remodeling at centromere (GO:0031055)	2.94793015
85	auditory receptor cell differentiation (GO:0042491)	2.94596615
86	deoxyribose phosphate metabolic process (GO:0019692)	2.94069173
87	viral mRNA export from host cell nucleus (GO:0046784)	2.92770858
88	protein deneddylation (GO:0000338)	2.90042341
89	positive regulation of translational initiation (GO:0045948)	2.86209531
90	deoxyribonucleotide catabolic process (GO:0009264)	2.85665924
91	protein localization to kinetochore (GO:0034501)	2.84996345
92	purine deoxyribonucleotide metabolic process (GO:0009151)	2.82636603
93	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.82568049
94	platelet dense granule organization (GO:0060155)	2.82021505
95	negative regulation of monooxygenase activity (GO:0032769)	2.81898293
96	deoxyribose phosphate catabolic process (GO:0046386)	2.79363254
97	positive regulation of protein homodimerization activity (GO:0090073)	2.79307094
98	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.79082439
99	telomere maintenance via semi-conservative replication (GO:0032201)	2.78732194
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.78048322

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.01133211
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.94272158
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.29258579
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.15747345
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54587978
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.40824837
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.38945942
8	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.10063921
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.94197231
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.89305073
11	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.57647706
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55975986
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.51922510
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.45971295
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.39379918
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38152845
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.37459710
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34774062
19	VDR_22108803_ChIP-Seq_LS180_Human	2.22450705
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.17433329
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12762607
22	MYB_26560356_Chip-Seq_TH2_Human	2.11694177
23	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.10780751
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.10757643
25	FOXP3_21729870_ChIP-Seq_TREG_Human	2.10445145
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.09425325
27	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.95882235
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.92320688
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91421899
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.89963114
31	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.86856269
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.78533195
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75202694
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.74584048
35	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.67756258
36	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.67208894
37	EZH2_22144423_ChIP-Seq_EOC_Human	1.61053725
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.57781182
39	GATA3_26560356_Chip-Seq_TH2_Human	1.52233577
40	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.45330140
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43690618
42	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.43396190
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42766231
44	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.41908847
45	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.41017536
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36439614
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.31622394
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.28545748
49	GATA3_27048872_Chip-Seq_THYMUS_Human	1.27075939
50	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.26308675
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.26111759
52	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25645984
53	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.21110362
54	CIITA_25753668_ChIP-Seq_RAJI_Human	1.18328852
55	ZNF274_21170338_ChIP-Seq_K562_Hela	1.17578017
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.16196450
57	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.13904598
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13286569
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12460312
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.12176020
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.08968691
62	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07524798
63	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.07073683
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06862130
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05781564
66	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05298612
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04939153
68	AR_20517297_ChIP-Seq_VCAP_Human	1.04067590
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03955629
70	ERG_20517297_ChIP-Seq_VCAP_Human	1.02438883
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01095388
72	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.00581116
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98782091
74	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.97536674
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96899093
76	TP53_22573176_ChIP-Seq_HFKS_Human	0.96112754
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95500202
78	P300_27268052_Chip-Seq_Bcells_Human	0.94294227
79	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.94065009
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93823785
81	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93817598
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92498524
83	BCL6_27268052_Chip-Seq_Bcells_Human	0.91683415
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91626560
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90683694
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.90282282
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.90282282
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89381561
89	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89221041
90	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88213534
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87996700
92	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.87971012
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.87960838
94	NCOR_22424771_ChIP-Seq_293T_Human	0.86289883
95	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.86010376
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.85481833
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.85481833
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85103370
99	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.85017476
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.84623316

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	5.49686172
2	MP0005671_abnormal_response_to	4.84310622
3	MP0004147_increased_porphyrin_level	4.33900564
4	MP0003763_abnormal_thymus_physiology	3.47932686
5	MP0001485_abnormal_pinna_reflex	2.48602454
6	MP0002166_altered_tumor_susceptibility	2.45940731
7	MP0009333_abnormal_splenocyte_physiolog	2.35082381
8	MP0005645_abnormal_hypothalamus_physiol	2.21151706
9	MP0001873_stomach_inflammation	2.18790579
10	MP0001835_abnormal_antigen_presentation	2.05711665
11	MP0009785_altered_susceptibility_to	2.04611263
12	MP0003693_abnormal_embryo_hatching	2.00264626
13	MP0001905_abnormal_dopamine_level	1.93656616
14	MP0003806_abnormal_nucleotide_metabolis	1.87574778
15	MP0003183_abnormal_peptide_metabolism	1.86115744
16	MP0002933_joint_inflammation	1.82621308
17	MP0002006_tumorigenesis	1.81804639
18	MP0001800_abnormal_humoral_immune	1.76946501
19	MP0003283_abnormal_digestive_organ	1.76467131
20	MP0005084_abnormal_gallbladder_morpholo	1.67220816
21	MP0008877_abnormal_DNA_methylation	1.65923975
22	MP0003878_abnormal_ear_physiology	1.65429452
23	MP0005377_hearing/vestibular/ear_phenot	1.65429452
24	MP0010094_abnormal_chromosome_stability	1.62256111
25	MP0005551_abnormal_eye_electrophysiolog	1.59735050
26	MP0010386_abnormal_urinary_bladder	1.56098087
27	MP0005000_abnormal_immune_tolerance	1.53557711
28	MP0004145_abnormal_muscle_electrophysio	1.49576807
29	MP0002420_abnormal_adaptive_immunity	1.49044842
30	MP0006292_abnormal_olfactory_placode	1.44248795
31	MP0001790_abnormal_immune_system	1.43811493
32	MP0005387_immune_system_phenotype	1.43811493
33	MP0002723_abnormal_immune_serum	1.41166730
34	MP0002138_abnormal_hepatobiliary_system	1.40375609
35	MP0001819_abnormal_immune_cell	1.39531838
36	MP0005025_abnormal_response_to	1.37852650
37	MP0002102_abnormal_ear_morphology	1.37275756
38	MP0008789_abnormal_olfactory_epithelium	1.36492780
39	MP0003786_premature_aging	1.35972805
40	MP0002837_dystrophic_cardiac_calcinosis	1.35528300
41	MP0003195_calcinosis	1.35297620
42	MP0006082_CNS_inflammation	1.34727520
43	MP0002160_abnormal_reproductive_system	1.31495902
44	MP0005389_reproductive_system_phenotype	1.30291334
45	MP0005646_abnormal_pituitary_gland	1.28007801
46	MP0003011_delayed_dark_adaptation	1.27635475
47	MP0003866_abnormal_defecation	1.26943140
48	MP0002452_abnormal_antigen_presenting	1.26715840
49	MP0006072_abnormal_retinal_apoptosis	1.26578522
50	MP0006036_abnormal_mitochondrial_physio	1.25365518
51	MP0002876_abnormal_thyroid_physiology	1.23946082
52	MP0002234_abnormal_pharynx_morphology	1.23448089
53	MP0003718_maternal_effect	1.22986967
54	MP0008875_abnormal_xenobiotic_pharmacok	1.22939299
55	MP0001542_abnormal_bone_strength	1.22775207
56	MP0001968_abnormal_touch/_nociception	1.22257852
57	MP0008872_abnormal_physiological_respon	1.21899201
58	MP0004957_abnormal_blastocyst_morpholog	1.18663342
59	MP0001845_abnormal_inflammatory_respons	1.16705401
60	MP0002398_abnormal_bone_marrow	1.16197625
61	MP0002638_abnormal_pupillary_reflex	1.13954793
62	MP0000685_abnormal_immune_system	1.13851965
63	MP0002148_abnormal_hypersensitivity_rea	1.12677408
64	MP0000716_abnormal_immune_system	1.09735451
65	MP0000703_abnormal_thymus_morphology	1.08076432
66	MP0000689_abnormal_spleen_morphology	1.04428730
67	MP0008932_abnormal_embryonic_tissue	1.03203371
68	MP0001764_abnormal_homeostasis	1.01162861
69	MP0003111_abnormal_nucleus_morphology	1.00703276
70	MP0002822_catalepsy	1.00084405
71	MP0004742_abnormal_vestibular_system	0.99676329
72	MP0005647_abnormal_sex_gland	0.97753739
73	MP0001919_abnormal_reproductive_system	0.97112988
74	MP0003252_abnormal_bile_duct	0.95148434
75	MP0004142_abnormal_muscle_tone	0.94425625
76	MP0001986_abnormal_taste_sensitivity	0.92315927
77	MP0002736_abnormal_nociception_after	0.90874378
78	MP0005394_taste/olfaction_phenotype	0.89613052
79	MP0005499_abnormal_olfactory_system	0.89613052
80	MP0002722_abnormal_immune_system	0.89134596
81	MP0001666_abnormal_nutrient_absorption	0.87287078
82	MP0000681_abnormal_thyroid_gland	0.85796116
83	MP0002405_respiratory_system_inflammati	0.85122945
84	MP0002429_abnormal_blood_cell	0.83679317
85	MP0008007_abnormal_cellular_replicative	0.78941079
86	MP0000372_irregular_coat_pigmentation	0.77032124
87	MP0003448_altered_tumor_morphology	0.76125269
88	MP0001486_abnormal_startle_reflex	0.74708886
89	MP0005636_abnormal_mineral_homeostasis	0.74562903
90	MP0001188_hyperpigmentation	0.74279407
91	MP0002019_abnormal_tumor_incidence	0.73801766
92	MP0005395_other_phenotype	0.73654039
93	MP0002653_abnormal_ependyma_morphology	0.72538742
94	MP0001929_abnormal_gametogenesis	0.71112843
95	MP0010155_abnormal_intestine_physiology	0.70902157
96	MP0002693_abnormal_pancreas_physiology	0.70758766
97	MP0001119_abnormal_female_reproductive	0.70727417
98	MP0000639_abnormal_adrenal_gland	0.69705477
99	MP0008260_abnormal_autophagy	0.69578631
100	MP0005253_abnormal_eye_physiology	0.67983945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of B cell number (HP:0010975)	6.29138370
2	B lymphocytopenia (HP:0010976)	6.23216763
3	Increased IgM level (HP:0003496)	5.47934619
4	Aplastic anemia (HP:0001915)	4.93637621
5	IgG deficiency (HP:0004315)	4.48135580
6	T lymphocytopenia (HP:0005403)	4.44406019
7	Abnormality of T cell number (HP:0011839)	4.22241162
8	Severe combined immunodeficiency (HP:0004430)	3.99462099
9	Combined immunodeficiency (HP:0005387)	3.65487206
10	Abnormality of the prostate (HP:0008775)	3.61823273
11	Hypoproteinemia (HP:0003075)	3.54460025
12	Pancytopenia (HP:0001876)	3.48555519
13	Abolished electroretinogram (ERG) (HP:0000550)	3.43714117
14	Autoimmune hemolytic anemia (HP:0001890)	3.41552905
15	Decreased central vision (HP:0007663)	3.39683070
16	Attenuation of retinal blood vessels (HP:0007843)	3.34138909
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.05201219
18	Elevated erythrocyte sedimentation rate (HP:0003565)	3.00246769
19	Mitochondrial inheritance (HP:0001427)	2.94276173
20	Chromsome breakage (HP:0040012)	2.93291773
21	Pendular nystagmus (HP:0012043)	2.88452776
22	Thyroiditis (HP:0100646)	2.85062287
23	Abnormality of T cells (HP:0002843)	2.74856032
24	Increased hepatocellular lipid droplets (HP:0006565)	2.73840264
25	Gastrointestinal infarctions (HP:0005244)	2.70834971
26	Encephalitis (HP:0002383)	2.69250366
27	Lymphopenia (HP:0001888)	2.68433250
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.63971925
29	Increased corneal curvature (HP:0100692)	2.63694692
30	Keratoconus (HP:0000563)	2.63694692
31	Acute necrotizing encephalopathy (HP:0006965)	2.63045864
32	Cerebral palsy (HP:0100021)	2.62646925
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.60498201
34	Hypoplasia of the thymus (HP:0000778)	2.59050709
35	IgM deficiency (HP:0002850)	2.56230280
36	Increased intramyocellular lipid droplets (HP:0012240)	2.55435181
37	Recurrent bronchitis (HP:0002837)	2.53667276
38	Abnormality of binocular vision (HP:0011514)	2.52210710
39	Diplopia (HP:0000651)	2.52210710
40	Renal Fanconi syndrome (HP:0001994)	2.50101969
41	Chronic diarrhea (HP:0002028)	2.47962570
42	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.45370849
43	Ureteral stenosis (HP:0000071)	2.41176937
44	Cellular immunodeficiency (HP:0005374)	2.38356040
45	Chronic obstructive pulmonary disease (HP:0006510)	2.37729477
46	Obstructive lung disease (HP:0006536)	2.37729477
47	3-Methylglutaconic aciduria (HP:0003535)	2.34579762
48	Increased CSF lactate (HP:0002490)	2.33918531
49	Colon cancer (HP:0003003)	2.32595532
50	Autoimmune thrombocytopenia (HP:0001973)	2.32428904
51	Amyotrophic lateral sclerosis (HP:0007354)	2.31323815
52	Generalized aminoaciduria (HP:0002909)	2.29671737
53	Hepatic necrosis (HP:0002605)	2.29192881
54	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.25696033
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.25696033
56	Abnormality of the renal collecting system (HP:0004742)	2.25125773
57	Lipid accumulation in hepatocytes (HP:0006561)	2.23131024
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21004947
59	Pancreatic fibrosis (HP:0100732)	2.19130600
60	Reticulocytopenia (HP:0001896)	2.16046935
61	Oral leukoplakia (HP:0002745)	2.15610484
62	Hepatocellular necrosis (HP:0001404)	2.15443249
63	Amaurosis fugax (HP:0100576)	2.11415250
64	Ureteral obstruction (HP:0006000)	2.10732916
65	Lymphoma (HP:0002665)	2.09436397
66	Duplicated collecting system (HP:0000081)	2.07021805
67	Meningitis (HP:0001287)	2.05420004
68	Mediastinal lymphadenopathy (HP:0100721)	2.05288449
69	Progressive macrocephaly (HP:0004481)	2.04402881
70	Optic disc pallor (HP:0000543)	2.03102451
71	Acute hepatic failure (HP:0006554)	2.01637529
72	Joint swelling (HP:0001386)	2.01540133
73	Macular degeneration (HP:0000608)	2.01523937
74	Abnormality of eosinophils (HP:0001879)	1.99444495
75	Abnormality of male internal genitalia (HP:0000022)	1.98922673
76	Dicarboxylic aciduria (HP:0003215)	1.97316309
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.97316309
78	Increased muscle lipid content (HP:0009058)	1.96862078
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.96133109
80	Acute encephalopathy (HP:0006846)	1.96092669
81	Hypergammaglobulinemia (HP:0010702)	1.92149175
82	Gonadotropin excess (HP:0000837)	1.87951212
83	Exertional dyspnea (HP:0002875)	1.87764936
84	Vertebral compression fractures (HP:0002953)	1.86192015
85	Chest pain (HP:0100749)	1.86124441
86	Recurrent sinusitis (HP:0011108)	1.85779980
87	Neoplasm of the adrenal gland (HP:0100631)	1.80978087
88	Horseshoe kidney (HP:0000085)	1.80567073
89	Periorbital edema (HP:0100539)	1.79591370
90	Absent thumb (HP:0009777)	1.79537301
91	Gout (HP:0001997)	1.75955961
92	Premature graying of hair (HP:0002216)	1.74062743
93	Increased serum lactate (HP:0002151)	1.73462184
94	Bronchitis (HP:0012387)	1.73170260
95	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.72911636
96	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.72775700
97	Neutropenia (HP:0001875)	1.72219306
98	Abnormality of midbrain morphology (HP:0002418)	1.71753767
99	Molar tooth sign on MRI (HP:0002419)	1.71753767
100	Pigmentary retinal degeneration (HP:0001146)	1.71500050

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	6.69685896
2	KDR	5.99072317
3	VRK2	3.56039601
4	TESK1	3.32148004
5	LIMK1	3.08452733
6	MAP3K12	2.88139832
7	TXK	2.79990217
8	BUB1	2.73996371
9	MAP4K1	2.32314503
10	PLK4	2.29927396
11	NUAK1	2.13962402
12	MAP3K11	1.93717409
13	VRK1	1.93298352
14	BRSK2	1.88498388
15	ADRBK2	1.68991870
16	MAP4K2	1.68501744
17	TAOK3	1.59026408
18	ITK	1.57655743
19	NEK1	1.27847380
20	TAF1	1.27341306
21	BCKDK	1.23112870
22	BRSK1	1.22875017
23	GRK5	1.22135115
24	GRK1	1.19547365
25	BLK	1.16242759
26	MST4	1.07616826
27	CDC7	1.04511533
28	TEC	1.00946297
29	GRK7	0.98902447
30	CDK8	0.95550754
31	WNK4	0.94730469
32	NME1	0.94518251
33	DAPK1	0.90324382
34	ZAK	0.89686718
35	PLK3	0.86911420
36	ZAP70	0.85658426
37	CSNK1G3	0.84815516
38	SYK	0.84651771
39	DYRK2	0.83917013
40	CAMKK2	0.83563300
41	CSF1R	0.82452801
42	MYLK	0.80095456
43	MELK	0.77451136
44	BMPR1B	0.75101138
45	EIF2AK1	0.73234082
46	FRK	0.72651030
47	AURKA	0.71424566
48	DYRK1B	0.71171927
49	CDK9	0.69803328
50	LATS1	0.69669366
51	CSK	0.68759740
52	PLK1	0.65799499
53	CSNK1G1	0.64860715
54	BTK	0.63855228
55	WEE1	0.63215926
56	AURKB	0.61177321
57	LRRK2	0.61160654
58	PRKD3	0.60173086
59	FES	0.59942956
60	STK16	0.58268535
61	CSNK1A1L	0.57121520
62	LYN	0.55421839
63	INSRR	0.55053052
64	CDK7	0.54470456
65	LCK	0.53977723
66	ATR	0.52607742
67	PRKCQ	0.52510975
68	CDK11A	0.51737770
69	MAP3K5	0.49755271
70	CDK14	0.47622561
71	RPS6KA5	0.47303915
72	CDK18	0.46655292
73	CDK15	0.46502513
74	BCR	0.46235004
75	CSNK1G2	0.44798651
76	WNK3	0.44203462
77	RPS6KA4	0.42797132
78	CSNK2A1	0.42021106
79	TNK2	0.41900924
80	TYRO3	0.41253121
81	EIF2AK3	0.41240994
82	ROCK1	0.40820135
83	PAK1	0.39367408
84	TIE1	0.39258542
85	MAPKAPK2	0.38003359
86	EIF2AK2	0.37613043
87	CLK1	0.37024558
88	PLK2	0.36019089
89	TBK1	0.35453219
90	DAPK3	0.32098930
91	SRPK1	0.32057996
92	PIM2	0.31815455
93	PKN1	0.31687478
94	ERBB3	0.29669937
95	MAPK13	0.29590175
96	DYRK1A	0.29282166
97	TLK1	0.28823635
98	PRKCA	0.27389428
99	NTRK2	0.27220102
100	WNK1	0.27139082

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.40760621
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.53549780
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.52411343
4	Parkinsons disease_Homo sapiens_hsa05012	3.39960383
5	DNA replication_Homo sapiens_hsa03030	2.75437963
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.48221093
7	Mismatch repair_Homo sapiens_hsa03430	2.38696509
8	Protein export_Homo sapiens_hsa03060	2.29400616
9	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.27958141
10	RNA polymerase_Homo sapiens_hsa03020	2.26983294
11	Alzheimers disease_Homo sapiens_hsa05010	2.24750008
12	Huntingtons disease_Homo sapiens_hsa05016	2.14137342
13	Homologous recombination_Homo sapiens_hsa03440	2.07504485
14	Ribosome_Homo sapiens_hsa03010	2.01026681
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.86476445
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.80091120
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.74896804
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.72717814
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.65571928
20	One carbon pool by folate_Homo sapiens_hsa00670	1.65128977
21	Butanoate metabolism_Homo sapiens_hsa00650	1.62092288
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48730966
23	Allograft rejection_Homo sapiens_hsa05330	1.48596771
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.47327991
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45367962
26	Base excision repair_Homo sapiens_hsa03410	1.43579041
27	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.38368280
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.33183723
29	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.32131177
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31906518
31	Shigellosis_Homo sapiens_hsa05131	1.28213829
32	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.28076646
33	RNA degradation_Homo sapiens_hsa03018	1.27629943
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25387991
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.24998185
36	Phototransduction_Homo sapiens_hsa04744	1.23688046
37	Purine metabolism_Homo sapiens_hsa00230	1.23212013
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.15875070
39	Asthma_Homo sapiens_hsa05310	1.13620366
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02258489
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98806079
42	Viral myocarditis_Homo sapiens_hsa05416	0.96643906
43	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96481991
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93662912
45	Salmonella infection_Homo sapiens_hsa05132	0.91830902
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.88419157
47	Folate biosynthesis_Homo sapiens_hsa00790	0.87286788
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.86857798
49	RNA transport_Homo sapiens_hsa03013	0.82889700
50	Spliceosome_Homo sapiens_hsa03040	0.82687300
51	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74559084
52	Measles_Homo sapiens_hsa05162	0.74540433
53	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.74122196
54	Basal transcription factors_Homo sapiens_hsa03022	0.69113924
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64623545
56	Cell cycle_Homo sapiens_hsa04110	0.64262796
57	Peroxisome_Homo sapiens_hsa04146	0.63816600
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63812038
59	Olfactory transduction_Homo sapiens_hsa04740	0.60540344
60	Taste transduction_Homo sapiens_hsa04742	0.58045176
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57049528
62	Non-homologous end-joining_Homo sapiens_hsa03450	0.57045358
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.55584707
64	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53159713
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52558544
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51903212
67	Oocyte meiosis_Homo sapiens_hsa04114	0.51899602
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.50682230
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.50514812
70	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.48822008
71	Metabolic pathways_Homo sapiens_hsa01100	0.48110519
72	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.45847618
73	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.45746150
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45296090
75	Fatty acid degradation_Homo sapiens_hsa00071	0.42972302
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.38763366
77	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.38284454
78	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36965936
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.36778965
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36599707
81	Prion diseases_Homo sapiens_hsa05020	0.36593768
82	Retinol metabolism_Homo sapiens_hsa00830	0.35272422
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32193269
84	p53 signaling pathway_Homo sapiens_hsa04115	0.29997892
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29798354
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.29513064
87	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.29205619
88	Propanoate metabolism_Homo sapiens_hsa00640	0.28033033
89	mRNA surveillance pathway_Homo sapiens_hsa03015	0.27890707
90	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.26890560
91	Legionellosis_Homo sapiens_hsa05134	0.26613416
92	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.26159057
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24287140
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.23484545
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.22392550
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.21801836
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21179002
98	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.21008053
99	Glutathione metabolism_Homo sapiens_hsa00480	0.20808358
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.19749177

HMGN2P39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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