HMGN2P39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)6.73457797
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.63918630
3actin nucleation (GO:0045010)5.87411166
4cytidine metabolic process (GO:0046087)5.44885584
5cytidine catabolic process (GO:0006216)5.44885584
6cytidine deamination (GO:0009972)5.44885584
7DNA deamination (GO:0045006)5.40817534
8sequestering of actin monomers (GO:0042989)5.14915994
9regulation of B cell receptor signaling pathway (GO:0050855)4.96980808
10gonadal mesoderm development (GO:0007506)4.76900381
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.74117996
12deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.65210667
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.64126078
14positive regulation of natural killer cell mediated immunity (GO:0002717)4.42781196
15cytolysis (GO:0019835)4.27913766
16deoxyribose phosphate biosynthetic process (GO:0046385)4.27574630
172-deoxyribonucleotide biosynthetic process (GO:0009265)4.27574630
18activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.26685923
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25914641
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.22663102
21negative regulation by host of viral transcription (GO:0043922)4.17918153
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.99631114
23negative regulation of stress fiber assembly (GO:0051497)3.93840573
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.92966404
25regulation of cellular amino acid metabolic process (GO:0006521)3.92724330
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88601633
27ATP synthesis coupled proton transport (GO:0015986)3.88601633
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88505990
29intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.87431030
30signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.87431030
31negative regulation of ligase activity (GO:0051352)3.87328235
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.87328235
33protein maturation by protein folding (GO:0022417)3.85140865
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.84718429
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.84718429
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.84718429
37respiratory electron transport chain (GO:0022904)3.81350137
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75034096
39electron transport chain (GO:0022900)3.73618392
40regulation of natural killer cell mediated immunity (GO:0002715)3.69849646
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.69849646
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.68399853
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.68399853
44positive regulation of lamellipodium assembly (GO:0010592)3.67803771
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67264838
46macrophage chemotaxis (GO:0048246)3.67203707
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67180819
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.62854424
49deoxyribonucleotide biosynthetic process (GO:0009263)3.60284016
50piRNA metabolic process (GO:0034587)3.58195797
51negative regulation of T cell differentiation in thymus (GO:0033085)3.53232558
52histone H2A acetylation (GO:0043968)3.52263816
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42702675
54purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.38429171
55pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.38197554
56deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.36852996
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28915209
58negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.23277105
59ubiquinone biosynthetic process (GO:0006744)3.23057363
60positive thymic T cell selection (GO:0045059)3.22346117
61positive regulation of T cell apoptotic process (GO:0070234)3.19272471
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.16616832
63DNA ligation (GO:0006266)3.14855603
64negative regulation of oxidoreductase activity (GO:0051354)3.14673486
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14451987
66positive regulation of ligase activity (GO:0051351)3.13639926
67positive regulation of cell cycle arrest (GO:0071158)3.12132803
682-deoxyribonucleotide metabolic process (GO:0009394)3.07543236
69CENP-A containing nucleosome assembly (GO:0034080)3.06882210
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.04979766
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04960262
72negative regulation of cell fate specification (GO:0009996)3.02839466
73ubiquinone metabolic process (GO:0006743)3.02548681
74DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.00492541
75iron-sulfur cluster assembly (GO:0016226)2.99327845
76metallo-sulfur cluster assembly (GO:0031163)2.99327845
77positive regulation of lamellipodium organization (GO:1902745)2.97522795
78regulation of cellular amine metabolic process (GO:0033238)2.97298097
79execution phase of apoptosis (GO:0097194)2.97017411
80purine deoxyribonucleotide catabolic process (GO:0009155)2.96758800
81negative regulation of actin filament bundle assembly (GO:0032232)2.95875029
82mechanosensory behavior (GO:0007638)2.95424157
83mismatch repair (GO:0006298)2.95193834
84chromatin remodeling at centromere (GO:0031055)2.94793015
85auditory receptor cell differentiation (GO:0042491)2.94596615
86deoxyribose phosphate metabolic process (GO:0019692)2.94069173
87viral mRNA export from host cell nucleus (GO:0046784)2.92770858
88protein deneddylation (GO:0000338)2.90042341
89positive regulation of translational initiation (GO:0045948)2.86209531
90deoxyribonucleotide catabolic process (GO:0009264)2.85665924
91protein localization to kinetochore (GO:0034501)2.84996345
92purine deoxyribonucleotide metabolic process (GO:0009151)2.82636603
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.82568049
94platelet dense granule organization (GO:0060155)2.82021505
95negative regulation of monooxygenase activity (GO:0032769)2.81898293
96deoxyribose phosphate catabolic process (GO:0046386)2.79363254
97positive regulation of protein homodimerization activity (GO:0090073)2.79307094
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79082439
99telomere maintenance via semi-conservative replication (GO:0032201)2.78732194
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78048322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.01133211
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.94272158
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.29258579
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15747345
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.54587978
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40824837
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.38945942
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10063921
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94197231
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89305073
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.57647706
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55975986
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51922510
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.45971295
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39379918
16IGF1R_20145208_ChIP-Seq_DFB_Human2.38152845
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37459710
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34774062
19VDR_22108803_ChIP-Seq_LS180_Human2.22450705
20VDR_23849224_ChIP-Seq_CD4+_Human2.17433329
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.12762607
22MYB_26560356_Chip-Seq_TH2_Human2.11694177
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.10780751
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10757643
25FOXP3_21729870_ChIP-Seq_TREG_Human2.10445145
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09425325
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95882235
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92320688
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91421899
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.89963114
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86856269
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78533195
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.75202694
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.74584048
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67756258
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67208894
37EZH2_22144423_ChIP-Seq_EOC_Human1.61053725
38ELK1_19687146_ChIP-ChIP_HELA_Human1.57781182
39GATA3_26560356_Chip-Seq_TH2_Human1.52233577
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45330140
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43690618
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43396190
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42766231
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41908847
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41017536
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36439614
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31622394
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.28545748
49GATA3_27048872_Chip-Seq_THYMUS_Human1.27075939
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26308675
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26111759
52HTT_18923047_ChIP-ChIP_STHdh_Human1.25645984
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21110362
54CIITA_25753668_ChIP-Seq_RAJI_Human1.18328852
55ZNF274_21170338_ChIP-Seq_K562_Hela1.17578017
56ER_23166858_ChIP-Seq_MCF-7_Human1.16196450
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13904598
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13286569
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12460312
60GABP_19822575_ChIP-Seq_HepG2_Human1.12176020
61MYC_18940864_ChIP-ChIP_HL60_Human1.08968691
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07524798
63CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07073683
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06862130
65DCP1A_22483619_ChIP-Seq_HELA_Human1.05781564
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05298612
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04939153
68AR_20517297_ChIP-Seq_VCAP_Human1.04067590
69TAF2_19829295_ChIP-Seq_ESCs_Human1.03955629
70ERG_20517297_ChIP-Seq_VCAP_Human1.02438883
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01095388
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.00581116
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98782091
74NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97536674
75ELK1_22589737_ChIP-Seq_MCF10A_Human0.96899093
76TP53_22573176_ChIP-Seq_HFKS_Human0.96112754
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.95500202
78P300_27268052_Chip-Seq_Bcells_Human0.94294227
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94065009
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93823785
81P53_21459846_ChIP-Seq_SAOS-2_Human0.93817598
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92498524
83BCL6_27268052_Chip-Seq_Bcells_Human0.91683415
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.91626560
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90683694
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.90282282
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90282282
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89381561
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89221041
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88213534
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.87996700
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87971012
93IRF1_19129219_ChIP-ChIP_H3396_Human0.87960838
94NCOR_22424771_ChIP-Seq_293T_Human0.86289883
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86010376
96SOX2_19829295_ChIP-Seq_ESCs_Human0.85481833
97NANOG_19829295_ChIP-Seq_ESCs_Human0.85481833
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85103370
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85017476
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84623316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.49686172
2MP0005671_abnormal_response_to4.84310622
3MP0004147_increased_porphyrin_level4.33900564
4MP0003763_abnormal_thymus_physiology3.47932686
5MP0001485_abnormal_pinna_reflex2.48602454
6MP0002166_altered_tumor_susceptibility2.45940731
7MP0009333_abnormal_splenocyte_physiolog2.35082381
8MP0005645_abnormal_hypothalamus_physiol2.21151706
9MP0001873_stomach_inflammation2.18790579
10MP0001835_abnormal_antigen_presentation2.05711665
11MP0009785_altered_susceptibility_to2.04611263
12MP0003693_abnormal_embryo_hatching2.00264626
13MP0001905_abnormal_dopamine_level1.93656616
14MP0003806_abnormal_nucleotide_metabolis1.87574778
15MP0003183_abnormal_peptide_metabolism1.86115744
16MP0002933_joint_inflammation1.82621308
17MP0002006_tumorigenesis1.81804639
18MP0001800_abnormal_humoral_immune1.76946501
19MP0003283_abnormal_digestive_organ1.76467131
20MP0005084_abnormal_gallbladder_morpholo1.67220816
21MP0008877_abnormal_DNA_methylation1.65923975
22MP0003878_abnormal_ear_physiology1.65429452
23MP0005377_hearing/vestibular/ear_phenot1.65429452
24MP0010094_abnormal_chromosome_stability1.62256111
25MP0005551_abnormal_eye_electrophysiolog1.59735050
26MP0010386_abnormal_urinary_bladder1.56098087
27MP0005000_abnormal_immune_tolerance1.53557711
28MP0004145_abnormal_muscle_electrophysio1.49576807
29MP0002420_abnormal_adaptive_immunity1.49044842
30MP0006292_abnormal_olfactory_placode1.44248795
31MP0001790_abnormal_immune_system1.43811493
32MP0005387_immune_system_phenotype1.43811493
33MP0002723_abnormal_immune_serum1.41166730
34MP0002138_abnormal_hepatobiliary_system1.40375609
35MP0001819_abnormal_immune_cell1.39531838
36MP0005025_abnormal_response_to1.37852650
37MP0002102_abnormal_ear_morphology1.37275756
38MP0008789_abnormal_olfactory_epithelium1.36492780
39MP0003786_premature_aging1.35972805
40MP0002837_dystrophic_cardiac_calcinosis1.35528300
41MP0003195_calcinosis1.35297620
42MP0006082_CNS_inflammation1.34727520
43MP0002160_abnormal_reproductive_system1.31495902
44MP0005389_reproductive_system_phenotype1.30291334
45MP0005646_abnormal_pituitary_gland1.28007801
46MP0003011_delayed_dark_adaptation1.27635475
47MP0003866_abnormal_defecation1.26943140
48MP0002452_abnormal_antigen_presenting1.26715840
49MP0006072_abnormal_retinal_apoptosis1.26578522
50MP0006036_abnormal_mitochondrial_physio1.25365518
51MP0002876_abnormal_thyroid_physiology1.23946082
52MP0002234_abnormal_pharynx_morphology1.23448089
53MP0003718_maternal_effect1.22986967
54MP0008875_abnormal_xenobiotic_pharmacok1.22939299
55MP0001542_abnormal_bone_strength1.22775207
56MP0001968_abnormal_touch/_nociception1.22257852
57MP0008872_abnormal_physiological_respon1.21899201
58MP0004957_abnormal_blastocyst_morpholog1.18663342
59MP0001845_abnormal_inflammatory_respons1.16705401
60MP0002398_abnormal_bone_marrow1.16197625
61MP0002638_abnormal_pupillary_reflex1.13954793
62MP0000685_abnormal_immune_system1.13851965
63MP0002148_abnormal_hypersensitivity_rea1.12677408
64MP0000716_abnormal_immune_system1.09735451
65MP0000703_abnormal_thymus_morphology1.08076432
66MP0000689_abnormal_spleen_morphology1.04428730
67MP0008932_abnormal_embryonic_tissue1.03203371
68MP0001764_abnormal_homeostasis1.01162861
69MP0003111_abnormal_nucleus_morphology1.00703276
70MP0002822_catalepsy1.00084405
71MP0004742_abnormal_vestibular_system0.99676329
72MP0005647_abnormal_sex_gland0.97753739
73MP0001919_abnormal_reproductive_system0.97112988
74MP0003252_abnormal_bile_duct0.95148434
75MP0004142_abnormal_muscle_tone0.94425625
76MP0001986_abnormal_taste_sensitivity0.92315927
77MP0002736_abnormal_nociception_after0.90874378
78MP0005394_taste/olfaction_phenotype0.89613052
79MP0005499_abnormal_olfactory_system0.89613052
80MP0002722_abnormal_immune_system0.89134596
81MP0001666_abnormal_nutrient_absorption0.87287078
82MP0000681_abnormal_thyroid_gland0.85796116
83MP0002405_respiratory_system_inflammati0.85122945
84MP0002429_abnormal_blood_cell0.83679317
85MP0008007_abnormal_cellular_replicative0.78941079
86MP0000372_irregular_coat_pigmentation0.77032124
87MP0003448_altered_tumor_morphology0.76125269
88MP0001486_abnormal_startle_reflex0.74708886
89MP0005636_abnormal_mineral_homeostasis0.74562903
90MP0001188_hyperpigmentation0.74279407
91MP0002019_abnormal_tumor_incidence0.73801766
92MP0005395_other_phenotype0.73654039
93MP0002653_abnormal_ependyma_morphology0.72538742
94MP0001929_abnormal_gametogenesis0.71112843
95MP0010155_abnormal_intestine_physiology0.70902157
96MP0002693_abnormal_pancreas_physiology0.70758766
97MP0001119_abnormal_female_reproductive0.70727417
98MP0000639_abnormal_adrenal_gland0.69705477
99MP0008260_abnormal_autophagy0.69578631
100MP0005253_abnormal_eye_physiology0.67983945

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)6.29138370
2B lymphocytopenia (HP:0010976)6.23216763
3Increased IgM level (HP:0003496)5.47934619
4Aplastic anemia (HP:0001915)4.93637621
5IgG deficiency (HP:0004315)4.48135580
6T lymphocytopenia (HP:0005403)4.44406019
7Abnormality of T cell number (HP:0011839)4.22241162
8Severe combined immunodeficiency (HP:0004430)3.99462099
9Combined immunodeficiency (HP:0005387)3.65487206
10Abnormality of the prostate (HP:0008775)3.61823273
11Hypoproteinemia (HP:0003075)3.54460025
12Pancytopenia (HP:0001876)3.48555519
13Abolished electroretinogram (ERG) (HP:0000550)3.43714117
14Autoimmune hemolytic anemia (HP:0001890)3.41552905
15Decreased central vision (HP:0007663)3.39683070
16Attenuation of retinal blood vessels (HP:0007843)3.34138909
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05201219
18Elevated erythrocyte sedimentation rate (HP:0003565)3.00246769
19Mitochondrial inheritance (HP:0001427)2.94276173
20Chromsome breakage (HP:0040012)2.93291773
21Pendular nystagmus (HP:0012043)2.88452776
22Thyroiditis (HP:0100646)2.85062287
23Abnormality of T cells (HP:0002843)2.74856032
24Increased hepatocellular lipid droplets (HP:0006565)2.73840264
25Gastrointestinal infarctions (HP:0005244)2.70834971
26Encephalitis (HP:0002383)2.69250366
27Lymphopenia (HP:0001888)2.68433250
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63971925
29Increased corneal curvature (HP:0100692)2.63694692
30Keratoconus (HP:0000563)2.63694692
31Acute necrotizing encephalopathy (HP:0006965)2.63045864
32Cerebral palsy (HP:0100021)2.62646925
33Abnormal mitochondria in muscle tissue (HP:0008316)2.60498201
34Hypoplasia of the thymus (HP:0000778)2.59050709
35IgM deficiency (HP:0002850)2.56230280
36Increased intramyocellular lipid droplets (HP:0012240)2.55435181
37Recurrent bronchitis (HP:0002837)2.53667276
38Abnormality of binocular vision (HP:0011514)2.52210710
39Diplopia (HP:0000651)2.52210710
40Renal Fanconi syndrome (HP:0001994)2.50101969
41Chronic diarrhea (HP:0002028)2.47962570
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.45370849
43Ureteral stenosis (HP:0000071)2.41176937
44Cellular immunodeficiency (HP:0005374)2.38356040
45Chronic obstructive pulmonary disease (HP:0006510)2.37729477
46Obstructive lung disease (HP:0006536)2.37729477
473-Methylglutaconic aciduria (HP:0003535)2.34579762
48Increased CSF lactate (HP:0002490)2.33918531
49Colon cancer (HP:0003003)2.32595532
50Autoimmune thrombocytopenia (HP:0001973)2.32428904
51Amyotrophic lateral sclerosis (HP:0007354)2.31323815
52Generalized aminoaciduria (HP:0002909)2.29671737
53Hepatic necrosis (HP:0002605)2.29192881
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25696033
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25696033
56Abnormality of the renal collecting system (HP:0004742)2.25125773
57Lipid accumulation in hepatocytes (HP:0006561)2.23131024
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21004947
59Pancreatic fibrosis (HP:0100732)2.19130600
60Reticulocytopenia (HP:0001896)2.16046935
61Oral leukoplakia (HP:0002745)2.15610484
62Hepatocellular necrosis (HP:0001404)2.15443249
63Amaurosis fugax (HP:0100576)2.11415250
64Ureteral obstruction (HP:0006000)2.10732916
65Lymphoma (HP:0002665)2.09436397
66Duplicated collecting system (HP:0000081)2.07021805
67Meningitis (HP:0001287)2.05420004
68Mediastinal lymphadenopathy (HP:0100721)2.05288449
69Progressive macrocephaly (HP:0004481)2.04402881
70Optic disc pallor (HP:0000543)2.03102451
71Acute hepatic failure (HP:0006554)2.01637529
72Joint swelling (HP:0001386)2.01540133
73Macular degeneration (HP:0000608)2.01523937
74Abnormality of eosinophils (HP:0001879)1.99444495
75Abnormality of male internal genitalia (HP:0000022)1.98922673
76Dicarboxylic aciduria (HP:0003215)1.97316309
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97316309
78Increased muscle lipid content (HP:0009058)1.96862078
79Abnormal rod and cone electroretinograms (HP:0008323)1.96133109
80Acute encephalopathy (HP:0006846)1.96092669
81Hypergammaglobulinemia (HP:0010702)1.92149175
82Gonadotropin excess (HP:0000837)1.87951212
83Exertional dyspnea (HP:0002875)1.87764936
84Vertebral compression fractures (HP:0002953)1.86192015
85Chest pain (HP:0100749)1.86124441
86Recurrent sinusitis (HP:0011108)1.85779980
87Neoplasm of the adrenal gland (HP:0100631)1.80978087
88Horseshoe kidney (HP:0000085)1.80567073
89Periorbital edema (HP:0100539)1.79591370
90Absent thumb (HP:0009777)1.79537301
91Gout (HP:0001997)1.75955961
92Premature graying of hair (HP:0002216)1.74062743
93Increased serum lactate (HP:0002151)1.73462184
94Bronchitis (HP:0012387)1.73170260
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72911636
96Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72775700
97Neutropenia (HP:0001875)1.72219306
98Abnormality of midbrain morphology (HP:0002418)1.71753767
99Molar tooth sign on MRI (HP:0002419)1.71753767
100Pigmentary retinal degeneration (HP:0001146)1.71500050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.69685896
2KDR5.99072317
3VRK23.56039601
4TESK13.32148004
5LIMK13.08452733
6MAP3K122.88139832
7TXK2.79990217
8BUB12.73996371
9MAP4K12.32314503
10PLK42.29927396
11NUAK12.13962402
12MAP3K111.93717409
13VRK11.93298352
14BRSK21.88498388
15ADRBK21.68991870
16MAP4K21.68501744
17TAOK31.59026408
18ITK1.57655743
19NEK11.27847380
20TAF11.27341306
21BCKDK1.23112870
22BRSK11.22875017
23GRK51.22135115
24GRK11.19547365
25BLK1.16242759
26MST41.07616826
27CDC71.04511533
28TEC1.00946297
29GRK70.98902447
30CDK80.95550754
31WNK40.94730469
32NME10.94518251
33DAPK10.90324382
34ZAK0.89686718
35PLK30.86911420
36ZAP700.85658426
37CSNK1G30.84815516
38SYK0.84651771
39DYRK20.83917013
40CAMKK20.83563300
41CSF1R0.82452801
42MYLK0.80095456
43MELK0.77451136
44BMPR1B0.75101138
45EIF2AK10.73234082
46FRK0.72651030
47AURKA0.71424566
48DYRK1B0.71171927
49CDK90.69803328
50LATS10.69669366
51CSK0.68759740
52PLK10.65799499
53CSNK1G10.64860715
54BTK0.63855228
55WEE10.63215926
56AURKB0.61177321
57LRRK20.61160654
58PRKD30.60173086
59FES0.59942956
60STK160.58268535
61CSNK1A1L0.57121520
62LYN0.55421839
63INSRR0.55053052
64CDK70.54470456
65LCK0.53977723
66ATR0.52607742
67PRKCQ0.52510975
68CDK11A0.51737770
69MAP3K50.49755271
70CDK140.47622561
71RPS6KA50.47303915
72CDK180.46655292
73CDK150.46502513
74BCR0.46235004
75CSNK1G20.44798651
76WNK30.44203462
77RPS6KA40.42797132
78CSNK2A10.42021106
79TNK20.41900924
80TYRO30.41253121
81EIF2AK30.41240994
82ROCK10.40820135
83PAK10.39367408
84TIE10.39258542
85MAPKAPK20.38003359
86EIF2AK20.37613043
87CLK10.37024558
88PLK20.36019089
89TBK10.35453219
90DAPK30.32098930
91SRPK10.32057996
92PIM20.31815455
93PKN10.31687478
94ERBB30.29669937
95MAPK130.29590175
96DYRK1A0.29282166
97TLK10.28823635
98PRKCA0.27389428
99NTRK20.27220102
100WNK10.27139082

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.40760621
2Primary immunodeficiency_Homo sapiens_hsa053404.53549780
3Oxidative phosphorylation_Homo sapiens_hsa001903.52411343
4Parkinsons disease_Homo sapiens_hsa050123.39960383
5DNA replication_Homo sapiens_hsa030302.75437963
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48221093
7Mismatch repair_Homo sapiens_hsa034302.38696509
8Protein export_Homo sapiens_hsa030602.29400616
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27958141
10RNA polymerase_Homo sapiens_hsa030202.26983294
11Alzheimers disease_Homo sapiens_hsa050102.24750008
12Huntingtons disease_Homo sapiens_hsa050162.14137342
13Homologous recombination_Homo sapiens_hsa034402.07504485
14Ribosome_Homo sapiens_hsa030102.01026681
15Antigen processing and presentation_Homo sapiens_hsa046121.86476445
16Autoimmune thyroid disease_Homo sapiens_hsa053201.80091120
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74896804
18Graft-versus-host disease_Homo sapiens_hsa053321.72717814
19Hematopoietic cell lineage_Homo sapiens_hsa046401.65571928
20One carbon pool by folate_Homo sapiens_hsa006701.65128977
21Butanoate metabolism_Homo sapiens_hsa006501.62092288
22Cardiac muscle contraction_Homo sapiens_hsa042601.48730966
23Allograft rejection_Homo sapiens_hsa053301.48596771
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47327991
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45367962
26Base excision repair_Homo sapiens_hsa034101.43579041
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38368280
28Nucleotide excision repair_Homo sapiens_hsa034201.33183723
29T cell receptor signaling pathway_Homo sapiens_hsa046601.32131177
30Pyrimidine metabolism_Homo sapiens_hsa002401.31906518
31Shigellosis_Homo sapiens_hsa051311.28213829
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28076646
33RNA degradation_Homo sapiens_hsa030181.27629943
34Fanconi anemia pathway_Homo sapiens_hsa034601.25387991
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24998185
36Phototransduction_Homo sapiens_hsa047441.23688046
37Purine metabolism_Homo sapiens_hsa002301.23212013
38Type I diabetes mellitus_Homo sapiens_hsa049401.15875070
39Asthma_Homo sapiens_hsa053101.13620366
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02258489
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98806079
42Viral myocarditis_Homo sapiens_hsa054160.96643906
43Linoleic acid metabolism_Homo sapiens_hsa005910.96481991
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93662912
45Salmonella infection_Homo sapiens_hsa051320.91830902
46Ether lipid metabolism_Homo sapiens_hsa005650.88419157
47Folate biosynthesis_Homo sapiens_hsa007900.87286788
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86857798
49RNA transport_Homo sapiens_hsa030130.82889700
50Spliceosome_Homo sapiens_hsa030400.82687300
51Rheumatoid arthritis_Homo sapiens_hsa053230.74559084
52Measles_Homo sapiens_hsa051620.74540433
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74122196
54Basal transcription factors_Homo sapiens_hsa030220.69113924
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.64623545
56Cell cycle_Homo sapiens_hsa041100.64262796
57Peroxisome_Homo sapiens_hsa041460.63816600
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63812038
59Olfactory transduction_Homo sapiens_hsa047400.60540344
60Taste transduction_Homo sapiens_hsa047420.58045176
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57049528
62Non-homologous end-joining_Homo sapiens_hsa034500.57045358
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.55584707
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53159713
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.52558544
66Arachidonic acid metabolism_Homo sapiens_hsa005900.51903212
67Oocyte meiosis_Homo sapiens_hsa041140.51899602
68Pyruvate metabolism_Homo sapiens_hsa006200.50682230
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50514812
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48822008
71Metabolic pathways_Homo sapiens_hsa011000.48110519
72Epstein-Barr virus infection_Homo sapiens_hsa051690.45847618
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45746150
74Systemic lupus erythematosus_Homo sapiens_hsa053220.45296090
75Fatty acid degradation_Homo sapiens_hsa000710.42972302
76Steroid biosynthesis_Homo sapiens_hsa001000.38763366
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38284454
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.36965936
79Fat digestion and absorption_Homo sapiens_hsa049750.36778965
80Collecting duct acid secretion_Homo sapiens_hsa049660.36599707
81Prion diseases_Homo sapiens_hsa050200.36593768
82Retinol metabolism_Homo sapiens_hsa008300.35272422
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32193269
84p53 signaling pathway_Homo sapiens_hsa041150.29997892
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29798354
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.29513064
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29205619
88Propanoate metabolism_Homo sapiens_hsa006400.28033033
89mRNA surveillance pathway_Homo sapiens_hsa030150.27890707
90Staphylococcus aureus infection_Homo sapiens_hsa051500.26890560
91Legionellosis_Homo sapiens_hsa051340.26613416
92Biosynthesis of amino acids_Homo sapiens_hsa012300.26159057
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.24287140
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23484545
95Chemical carcinogenesis_Homo sapiens_hsa052040.22392550
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21801836
97Vitamin digestion and absorption_Homo sapiens_hsa049770.21179002
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21008053
99Glutathione metabolism_Homo sapiens_hsa004800.20808358
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19749177

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