HMGN2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.12017504
2sequestering of actin monomers (GO:0042989)7.48954026
3ATP synthesis coupled proton transport (GO:0015986)7.26182807
4energy coupled proton transport, down electrochemical gradient (GO:0015985)7.26182807
5viral transcription (GO:0019083)6.46349243
6translational termination (GO:0006415)6.22032808
7ribosomal small subunit assembly (GO:0000028)5.94878688
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.57918990
9cotranslational protein targeting to membrane (GO:0006613)5.57029958
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.55984677
11protein targeting to ER (GO:0045047)5.44769174
12establishment of protein localization to mitochondrial membrane (GO:0090151)5.39765673
13respiratory electron transport chain (GO:0022904)5.33818149
14electron transport chain (GO:0022900)5.27203403
15translational elongation (GO:0006414)5.22853130
16establishment of protein localization to endoplasmic reticulum (GO:0072599)5.19751239
17protein localization to endoplasmic reticulum (GO:0070972)5.07953497
18cellular protein complex disassembly (GO:0043624)4.83670807
19inner mitochondrial membrane organization (GO:0007007)4.65320584
20viral life cycle (GO:0019058)4.65008244
21protein complex biogenesis (GO:0070271)4.64703616
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.58327390
23maturation of SSU-rRNA (GO:0030490)4.55308315
24chaperone-mediated protein transport (GO:0072321)4.37813881
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.34321305
26NADH dehydrogenase complex assembly (GO:0010257)4.34321305
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34321305
28mitochondrial respiratory chain complex assembly (GO:0033108)4.31420569
29translational initiation (GO:0006413)4.24176654
30protein complex disassembly (GO:0043241)4.07619802
31ATP biosynthetic process (GO:0006754)3.88545303
32protein neddylation (GO:0045116)3.87596567
33macromolecular complex disassembly (GO:0032984)3.85894389
34hydrogen ion transmembrane transport (GO:1902600)3.67301306
35protein-cofactor linkage (GO:0018065)3.66069794
36ribosomal small subunit biogenesis (GO:0042274)3.56737385
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.55662569
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.55485187
39protein targeting to membrane (GO:0006612)3.52788411
40ribosomal large subunit biogenesis (GO:0042273)3.51270485
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50770720
42CENP-A containing nucleosome assembly (GO:0034080)3.48548828
43neuron fate determination (GO:0048664)3.48354178
44chromatin remodeling at centromere (GO:0031055)3.46233623
45translation (GO:0006412)3.44152535
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.43248402
47midbrain development (GO:0030901)3.41505479
48behavioral response to nicotine (GO:0035095)3.40362294
49proton transport (GO:0015992)3.38374562
50hydrogen transport (GO:0006818)3.32112632
51mRNA catabolic process (GO:0006402)3.25146925
52proteasome assembly (GO:0043248)3.24858889
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24304031
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23610224
55epithelial cilium movement (GO:0003351)3.23373063
56DNA ligation (GO:0006266)3.18327741
57positive regulation of gastrulation (GO:2000543)3.13925769
58platelet dense granule organization (GO:0060155)3.08875703
59lateral sprouting from an epithelium (GO:0060601)3.05331354
60spliceosomal snRNP assembly (GO:0000387)3.04125699
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.02997436
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01400054
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01400054
64spliceosomal complex assembly (GO:0000245)2.99161220
65centriole replication (GO:0007099)2.97815948
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97322287
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95166377
68DNA deamination (GO:0045006)2.93206625
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90294157
70RNA catabolic process (GO:0006401)2.89404847
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89355793
72oxidative phosphorylation (GO:0006119)2.88701916
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87937484
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87937484
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87937484
76DNA damage response, detection of DNA damage (GO:0042769)2.87510252
77termination of RNA polymerase III transcription (GO:0006386)2.85688952
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.85688952
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84553844
80negative regulation of ligase activity (GO:0051352)2.84553844
81histone exchange (GO:0043486)2.81268045
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81077885
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80240424
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80240424
85somite development (GO:0061053)2.79553095
86intracellular protein transmembrane import (GO:0044743)2.79495198
87microtubule depolymerization (GO:0007019)2.77140342
88thalamus development (GO:0021794)2.77090708
89nucleoside triphosphate biosynthetic process (GO:0009142)2.76934051
90regulation of mitochondrial translation (GO:0070129)2.74768263
91otic vesicle formation (GO:0030916)2.74409423
92regulation of cellular amino acid metabolic process (GO:0006521)2.73160835
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70064099
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.70064099
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.69211901
96cullin deneddylation (GO:0010388)2.65588137
97mismatch repair (GO:0006298)2.64300402
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63885921
99protein deneddylation (GO:0000338)2.63664684
100limb bud formation (GO:0060174)2.60910675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28025169
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.22265587
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.09250418
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.08079410
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.79123930
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.50702271
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17927843
8VDR_22108803_ChIP-Seq_LS180_Human2.72254535
9ZNF274_21170338_ChIP-Seq_K562_Hela2.59455583
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59037026
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54929901
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51162748
13ELK1_19687146_ChIP-ChIP_HELA_Human2.44098636
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40233397
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.35563246
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35069081
17EZH2_22144423_ChIP-Seq_EOC_Human2.30238854
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28129601
19VDR_23849224_ChIP-Seq_CD4+_Human2.11309769
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.09264300
21EWS_26573619_Chip-Seq_HEK293_Human2.05309926
22FUS_26573619_Chip-Seq_HEK293_Human1.96389404
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83853057
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.81702593
25MYC_18940864_ChIP-ChIP_HL60_Human1.81072341
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76488391
27TAF15_26573619_Chip-Seq_HEK293_Human1.75748056
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74288403
29FOXP3_21729870_ChIP-Seq_TREG_Human1.69071225
30TTF2_22483619_ChIP-Seq_HELA_Human1.65221668
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64325903
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.61608416
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58696174
34IGF1R_20145208_ChIP-Seq_DFB_Human1.55928705
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55481922
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.55266210
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52035895
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.52026737
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49965194
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49294474
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48489940
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45578634
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43176541
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42107655
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.41169009
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38081583
47XRN2_22483619_ChIP-Seq_HELA_Human1.37866171
48P300_19829295_ChIP-Seq_ESCs_Human1.35065510
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.34569388
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31000729
51RNF2_27304074_Chip-Seq_NSC_Mouse1.29456419
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.29273435
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28999777
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28041259
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25480252
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22515559
57TP53_22573176_ChIP-Seq_HFKS_Human1.20251827
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19725419
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18033045
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.16885047
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15609005
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14639291
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.13874827
64GBX2_23144817_ChIP-Seq_PC3_Human1.11450719
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11277475
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09733130
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06651392
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05916302
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05765988
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04280936
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.04280936
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.04188228
73DCP1A_22483619_ChIP-Seq_HELA_Human1.03046315
74ER_23166858_ChIP-Seq_MCF-7_Human1.02277532
75ERG_20517297_ChIP-Seq_VCAP_Human1.01134521
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00123044
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00019797
78SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99572153
79AR_20517297_ChIP-Seq_VCAP_Human0.98483174
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98472289
81NANOG_19829295_ChIP-Seq_ESCs_Human0.98244051
82SOX2_19829295_ChIP-Seq_ESCs_Human0.98244051
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96953639
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96173657
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96173657
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92344815
87CBP_20019798_ChIP-Seq_JUKART_Human0.92344815
88IRF1_19129219_ChIP-ChIP_H3396_Human0.92084249
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90661933
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90116724
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90096957
92EED_16625203_ChIP-ChIP_MESCs_Mouse0.89738022
93HTT_18923047_ChIP-ChIP_STHdh_Human0.89013936
94NCOR_22424771_ChIP-Seq_293T_Human0.87585503
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86720240
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.85505361
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84376645
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83299073
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83051202
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81441955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.74868405
2MP0003136_yellow_coat_color3.85380602
3MP0000566_synostosis3.17987483
4MP0006292_abnormal_olfactory_placode3.06417592
5MP0010030_abnormal_orbit_morphology2.62453095
6MP0001529_abnormal_vocalization2.56177252
7MP0006072_abnormal_retinal_apoptosis2.46421700
8MP0002938_white_spotting2.35007407
9MP0003880_abnormal_central_pattern2.30405792
10MP0003283_abnormal_digestive_organ2.14814479
11MP0005084_abnormal_gallbladder_morpholo2.09776713
12MP0002102_abnormal_ear_morphology2.09715265
13MP0002653_abnormal_ependyma_morphology2.08047761
14MP0004142_abnormal_muscle_tone2.06278827
15MP0002736_abnormal_nociception_after2.03348141
16MP0002234_abnormal_pharynx_morphology2.02676250
17MP0003011_delayed_dark_adaptation2.00031826
18MP0000372_irregular_coat_pigmentation1.99941921
19MP0008995_early_reproductive_senescence1.94262645
20MP0002638_abnormal_pupillary_reflex1.93728940
21MP0001293_anophthalmia1.92506684
22MP0008058_abnormal_DNA_repair1.89710241
23MP0008789_abnormal_olfactory_epithelium1.80074402
24MP0000631_abnormal_neuroendocrine_gland1.78801176
25MP0002277_abnormal_respiratory_mucosa1.78065905
26MP0002282_abnormal_trachea_morphology1.74210867
27MP0005646_abnormal_pituitary_gland1.68743623
28MP0005551_abnormal_eye_electrophysiolog1.59147637
29MP0001968_abnormal_touch/_nociception1.56790216
30MP0005253_abnormal_eye_physiology1.56350036
31MP0001346_abnormal_lacrimal_gland1.56087542
32MP0002822_catalepsy1.53647565
33MP0001984_abnormal_olfaction1.49975249
34MP0006276_abnormal_autonomic_nervous1.48129070
35MP0004133_heterotaxia1.47823359
36MP0003938_abnormal_ear_development1.46912946
37MP0008875_abnormal_xenobiotic_pharmacok1.39483084
38MP0005394_taste/olfaction_phenotype1.39280065
39MP0005499_abnormal_olfactory_system1.39280065
40MP0001485_abnormal_pinna_reflex1.38436402
41MP0004885_abnormal_endolymph1.36522705
42MP0000026_abnormal_inner_ear1.29759206
43MP0001905_abnormal_dopamine_level1.28764281
44MP0004147_increased_porphyrin_level1.26802630
45MP0002837_dystrophic_cardiac_calcinosis1.25797024
46MP0000049_abnormal_middle_ear1.25027552
47MP0008877_abnormal_DNA_methylation1.21196176
48MP0002751_abnormal_autonomic_nervous1.20448723
49MP0001286_abnormal_eye_development1.17601669
50MP0009745_abnormal_behavioral_response1.16305764
51MP0002928_abnormal_bile_duct1.16300314
52MP0000778_abnormal_nervous_system1.11964699
53MP0003122_maternal_imprinting1.11841179
54MP0001486_abnormal_startle_reflex1.09767026
55MP0005423_abnormal_somatic_nervous1.07686863
56MP0002272_abnormal_nervous_system1.07634369
57MP0005391_vision/eye_phenotype1.06635515
58MP0000537_abnormal_urethra_morphology1.04446066
59MP0005171_absent_coat_pigmentation1.04151673
60MP0003718_maternal_effect1.04080989
61MP0002095_abnormal_skin_pigmentation1.03622977
62MP0003937_abnormal_limbs/digits/tail_de0.99941417
63MP0005195_abnormal_posterior_eye0.97440014
64MP0002697_abnormal_eye_size0.94171923
65MP0003119_abnormal_digestive_system0.92651295
66MP0004742_abnormal_vestibular_system0.92317827
67MP0010094_abnormal_chromosome_stability0.91899434
68MP0004145_abnormal_muscle_electrophysio0.91588516
69MP0005645_abnormal_hypothalamus_physiol0.90271848
70MP0009046_muscle_twitch0.89288826
71MP0001986_abnormal_taste_sensitivity0.88334834
72MP0002735_abnormal_chemical_nociception0.88321697
73MP0003878_abnormal_ear_physiology0.88022364
74MP0005377_hearing/vestibular/ear_phenot0.88022364
75MP0002752_abnormal_somatic_nervous0.87575385
76MP0003186_abnormal_redox_activity0.87462068
77MP0008872_abnormal_physiological_respon0.86381919
78MP0001324_abnormal_eye_pigmentation0.86205491
79MP0002572_abnormal_emotion/affect_behav0.86021797
80MP0008961_abnormal_basal_metabolism0.85733235
81MP0003890_abnormal_embryonic-extraembry0.83912530
82MP0006035_abnormal_mitochondrial_morpho0.83609138
83MP0000579_abnormal_nail_morphology0.83017105
84MP0002233_abnormal_nose_morphology0.82511864
85MP0001963_abnormal_hearing_physiology0.81426088
86MP0003786_premature_aging0.81116626
87MP0002064_seizures0.80901725
88MP0003806_abnormal_nucleotide_metabolis0.79610376
89MP0002210_abnormal_sex_determination0.77109674
90MP0003121_genomic_imprinting0.76049937
91MP0002557_abnormal_social/conspecific_i0.75911772
92MP0000647_abnormal_sebaceous_gland0.75637156
93MP0003195_calcinosis0.75403849
94MP0002734_abnormal_mechanical_nocicepti0.72393936
95MP0009250_abnormal_appendicular_skeleto0.71927002
96MP0002067_abnormal_sensory_capabilities0.71802534
97MP0001970_abnormal_pain_threshold0.70889974
98MP0001929_abnormal_gametogenesis0.68603901
99MP0000653_abnormal_sex_gland0.68479244
100MP0001764_abnormal_homeostasis0.66957241

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.62996377
2Mitochondrial inheritance (HP:0001427)4.46014523
3Increased hepatocellular lipid droplets (HP:0006565)4.45127555
4Abnormal number of erythroid precursors (HP:0012131)4.22102498
5Abnormal mitochondria in muscle tissue (HP:0008316)4.12076566
6Congenital, generalized hypertrichosis (HP:0004540)4.06786682
7Lipid accumulation in hepatocytes (HP:0006561)4.00061388
8Abnormality of cells of the erythroid lineage (HP:0012130)3.91168491
9Progressive macrocephaly (HP:0004481)3.82680348
10Acute encephalopathy (HP:0006846)3.81185990
11Reticulocytopenia (HP:0001896)3.78408688
12Increased CSF lactate (HP:0002490)3.73964490
13Hepatocellular necrosis (HP:0001404)3.62894963
14Renal Fanconi syndrome (HP:0001994)3.47124553
15Pancreatic cysts (HP:0001737)3.45671817
16True hermaphroditism (HP:0010459)3.40663693
17Hepatic necrosis (HP:0002605)3.36190517
183-Methylglutaconic aciduria (HP:0003535)3.29593432
19Septo-optic dysplasia (HP:0100842)3.28688693
20Macrocytic anemia (HP:0001972)3.20457852
21Pancreatic fibrosis (HP:0100732)3.17953073
22Cerebral edema (HP:0002181)2.96662470
23Abnormality of midbrain morphology (HP:0002418)2.90655306
24Molar tooth sign on MRI (HP:0002419)2.90655306
25Exertional dyspnea (HP:0002875)2.87800886
26Concave nail (HP:0001598)2.84188561
27Nephronophthisis (HP:0000090)2.83101147
28Medial flaring of the eyebrow (HP:0010747)2.73359134
29Increased intramyocellular lipid droplets (HP:0012240)2.73028643
30Optic disc pallor (HP:0000543)2.70573179
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64784438
32Colon cancer (HP:0003003)2.53096108
33Absent septum pellucidum (HP:0001331)2.49927022
34Abnormal ciliary motility (HP:0012262)2.45063087
35Type II lissencephaly (HP:0007260)2.37305435
36Abnormality of the labia minora (HP:0012880)2.37205640
37Abnormal respiratory motile cilium morphology (HP:0005938)2.35858530
38Abnormal respiratory epithelium morphology (HP:0012253)2.35858530
39Lactic acidosis (HP:0003128)2.32333187
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31870059
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31870059
42Optic nerve hypoplasia (HP:0000609)2.31613660
43Sclerocornea (HP:0000647)2.31164818
44Pendular nystagmus (HP:0012043)2.30627544
45Abnormal respiratory motile cilium physiology (HP:0012261)2.28650945
46Pallor (HP:0000980)2.25245528
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24363994
48Abnormality of the renal medulla (HP:0100957)2.22779811
49Gait imbalance (HP:0002141)2.22550692
50Maternal diabetes (HP:0009800)2.21511395
51Congenital primary aphakia (HP:0007707)2.21479325
52Congenital stationary night blindness (HP:0007642)2.20655203
53Increased serum lactate (HP:0002151)2.19924947
54Generalized aminoaciduria (HP:0002909)2.18259794
55Abnormality of renal resorption (HP:0011038)2.18244855
56Respiratory difficulties (HP:0002880)2.15216481
57Glycosuria (HP:0003076)2.14768921
58Abnormality of urine glucose concentration (HP:0011016)2.14768921
59Increased muscle lipid content (HP:0009058)2.14611576
60Partial duplication of thumb phalanx (HP:0009944)2.13772319
61Esophageal atresia (HP:0002032)2.12526670
62Leukodystrophy (HP:0002415)2.11840286
63Respiratory failure (HP:0002878)2.10813437
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09465201
65Nephrogenic diabetes insipidus (HP:0009806)2.07411037
66Cystic liver disease (HP:0006706)2.05073365
67Methylmalonic acidemia (HP:0002912)2.04198478
68Split foot (HP:0001839)2.04134269
69Partial duplication of the phalanx of hand (HP:0009999)2.02375352
70Abnormality of the septum pellucidum (HP:0007375)2.01907009
71Exercise intolerance (HP:0003546)2.00834425
72Bilateral microphthalmos (HP:0007633)1.97927394
73Anencephaly (HP:0002323)1.97306248
74Vaginal atresia (HP:0000148)1.97200625
75Genital tract atresia (HP:0001827)1.94457408
76Triphalangeal thumb (HP:0001199)1.94283156
77Hyperphosphaturia (HP:0003109)1.93017309
78Stomach cancer (HP:0012126)1.92519072
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.89628635
80Gastrointestinal atresia (HP:0002589)1.85676372
81Retinal dysplasia (HP:0007973)1.84599261
82Anophthalmia (HP:0000528)1.83323907
83Hyperglycinemia (HP:0002154)1.83169368
84Aplasia/hypoplasia of the uterus (HP:0008684)1.83014922
85Abnormality of the renal cortex (HP:0011035)1.82968653
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82687108
87Abolished electroretinogram (ERG) (HP:0000550)1.81354134
88Absent/shortened dynein arms (HP:0200106)1.79363735
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.79363735
90Abnormality of the pons (HP:0007361)1.77978473
91Type I transferrin isoform profile (HP:0003642)1.77036778
92Rib fusion (HP:0000902)1.76135497
93Hypoplasia of the pons (HP:0012110)1.75553956
94Lethargy (HP:0001254)1.75117024
95Decreased central vision (HP:0007663)1.75064620
96Humeroradial synostosis (HP:0003041)1.75047177
97Synostosis involving the elbow (HP:0003938)1.75047177
98Myokymia (HP:0002411)1.74597578
99Male pseudohermaphroditism (HP:0000037)1.72955964
100Aplastic anemia (HP:0001915)1.72576807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.09341883
2ZAK3.60639823
3VRK13.17686830
4BUB12.67527213
5TLK12.67331401
6BCKDK2.26654566
7WNK32.23256417
8NUAK12.20392519
9MAP4K22.07560079
10TAOK31.98456021
11MAPK151.91449825
12SRPK11.90181747
13PASK1.85146508
14DYRK21.81725445
15NME11.75952149
16EPHB21.69592439
17PLK41.67961230
18ADRBK21.64375809
19TNIK1.63955012
20PLK31.63471128
21WEE11.59271595
22STK161.59266201
23FGFR21.56835045
24BMPR1B1.54302157
25CDC71.47307940
26MKNK11.37390653
27CCNB11.35148615
28TAF11.31667798
29MAP3K41.22870449
30GRK11.22333671
31PINK11.21179172
32CDK81.20422433
33INSRR1.20281671
34NEK21.15312365
35TXK1.13923679
36TGFBR11.13664401
37DYRK31.11209282
38PNCK1.10785648
39BRSK21.07895483
40MAPK131.07478962
41CDK190.95590968
42WNK40.95267316
43MAP2K70.90034152
44UHMK10.89442813
45OXSR10.88003962
46RPS6KA50.85438301
47TRIM280.83821620
48NEK10.83575567
49TSSK60.81401144
50AURKB0.81248547
51TTK0.80736959
52KDR0.79692406
53PRKCG0.78624137
54KIT0.76237084
55EIF2AK30.76159640
56ADRBK10.73467753
57EPHA40.71299002
58MAP3K120.69737465
59CSNK1G30.69646283
60CASK0.68446926
61GRK70.68141928
62PLK20.66286876
63MARK10.65637170
64FRK0.64146666
65TIE10.64035651
66NTRK20.61645174
67PLK10.61020541
68CSNK1G20.60028398
69MAPKAPK50.59467513
70CHEK20.58648983
71ATR0.58088701
72RPS6KA40.57260098
73CSNK1G10.56540457
74CDK30.56272554
75CSNK2A10.55113910
76BCR0.54427231
77MUSK0.51960075
78EIF2AK20.51879609
79OBSCN0.51505637
80AURKA0.50550554
81TESK20.49673684
82MKNK20.49512438
83CSNK2A20.47021915
84MAP2K40.46461183
85EPHA30.46376086
86MINK10.45886393
87PRKCE0.40806734
88PRKACA0.40655681
89PHKG10.38836423
90PHKG20.38836423
91CSNK1A10.38211469
92STK38L0.37910461
93CSNK1A1L0.37747324
94PAK30.36883465
95ERBB30.36286188
96GRK60.36138117
97DYRK1A0.35295386
98GRK50.31837884
99CHUK0.31589195
100PKN10.30320746

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.12209281
2Oxidative phosphorylation_Homo sapiens_hsa001905.04001632
3Parkinsons disease_Homo sapiens_hsa050124.31128427
4Proteasome_Homo sapiens_hsa030503.73588626
5Huntingtons disease_Homo sapiens_hsa050163.02553651
6Alzheimers disease_Homo sapiens_hsa050102.88120330
7Protein export_Homo sapiens_hsa030602.74409573
8RNA polymerase_Homo sapiens_hsa030202.63619743
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.51083231
10Cardiac muscle contraction_Homo sapiens_hsa042602.36730367
11Mismatch repair_Homo sapiens_hsa034302.19675362
12Homologous recombination_Homo sapiens_hsa034402.06665604
13DNA replication_Homo sapiens_hsa030301.90295577
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85967050
15Spliceosome_Homo sapiens_hsa030401.84370204
16Fanconi anemia pathway_Homo sapiens_hsa034601.60992641
17Caffeine metabolism_Homo sapiens_hsa002321.49955456
18Phototransduction_Homo sapiens_hsa047441.47627692
19RNA degradation_Homo sapiens_hsa030181.41649371
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32860078
21Nucleotide excision repair_Homo sapiens_hsa034201.31059912
22Base excision repair_Homo sapiens_hsa034101.30982497
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20484677
24Basal transcription factors_Homo sapiens_hsa030221.13576617
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.12937915
26Nicotine addiction_Homo sapiens_hsa050331.10689227
27Asthma_Homo sapiens_hsa053101.09460624
28Linoleic acid metabolism_Homo sapiens_hsa005911.09286327
29Pyrimidine metabolism_Homo sapiens_hsa002401.09252144
30Purine metabolism_Homo sapiens_hsa002301.08823422
31Nitrogen metabolism_Homo sapiens_hsa009101.07194573
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06641397
33Basal cell carcinoma_Homo sapiens_hsa052171.05813682
34Butanoate metabolism_Homo sapiens_hsa006501.04900637
35One carbon pool by folate_Homo sapiens_hsa006701.02919560
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00473967
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97886202
38Tryptophan metabolism_Homo sapiens_hsa003800.97784222
39RNA transport_Homo sapiens_hsa030130.88006075
40Propanoate metabolism_Homo sapiens_hsa006400.86224323
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84103645
42Systemic lupus erythematosus_Homo sapiens_hsa053220.83124005
43Non-homologous end-joining_Homo sapiens_hsa034500.81136823
44Hedgehog signaling pathway_Homo sapiens_hsa043400.80842350
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79843306
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.78368081
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78037344
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77673176
49Chemical carcinogenesis_Homo sapiens_hsa052040.76671534
50Folate biosynthesis_Homo sapiens_hsa007900.76596083
51Peroxisome_Homo sapiens_hsa041460.74067718
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72084189
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.68809576
54Taste transduction_Homo sapiens_hsa047420.68050380
55Collecting duct acid secretion_Homo sapiens_hsa049660.66282357
56Metabolic pathways_Homo sapiens_hsa011000.65738829
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65596251
58Autoimmune thyroid disease_Homo sapiens_hsa053200.65141396
59Selenocompound metabolism_Homo sapiens_hsa004500.63826760
60Graft-versus-host disease_Homo sapiens_hsa053320.63596426
61Primary immunodeficiency_Homo sapiens_hsa053400.63436542
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63266065
63Olfactory transduction_Homo sapiens_hsa047400.61437222
64Allograft rejection_Homo sapiens_hsa053300.61136304
65Antigen processing and presentation_Homo sapiens_hsa046120.58903983
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57967063
67Arachidonic acid metabolism_Homo sapiens_hsa005900.55489991
68Type I diabetes mellitus_Homo sapiens_hsa049400.54325591
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52951172
70GABAergic synapse_Homo sapiens_hsa047270.52435339
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.50405297
72Pyruvate metabolism_Homo sapiens_hsa006200.50384026
73Rheumatoid arthritis_Homo sapiens_hsa053230.47484232
74Glutathione metabolism_Homo sapiens_hsa004800.47391754
75Retinol metabolism_Homo sapiens_hsa008300.45089749
76Regulation of autophagy_Homo sapiens_hsa041400.44740852
77Vitamin digestion and absorption_Homo sapiens_hsa049770.43593053
78Morphine addiction_Homo sapiens_hsa050320.42877600
79Fatty acid elongation_Homo sapiens_hsa000620.42650197
80Cell cycle_Homo sapiens_hsa041100.42154583
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.41217688
82Alcoholism_Homo sapiens_hsa050340.39337382
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38697385
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38640972
85Serotonergic synapse_Homo sapiens_hsa047260.37312770
86Ether lipid metabolism_Homo sapiens_hsa005650.36851827
87Sulfur metabolism_Homo sapiens_hsa009200.33062424
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28665057
89Fat digestion and absorption_Homo sapiens_hsa049750.28371129
90Oocyte meiosis_Homo sapiens_hsa041140.27966661
91Tyrosine metabolism_Homo sapiens_hsa003500.26928151
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24459477
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24169596
94Circadian entrainment_Homo sapiens_hsa047130.23699334
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.22478553
96Sulfur relay system_Homo sapiens_hsa041220.22389436
97Epstein-Barr virus infection_Homo sapiens_hsa051690.21547426
98Steroid biosynthesis_Homo sapiens_hsa001000.20010862
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18527578
100beta-Alanine metabolism_Homo sapiens_hsa004100.18120611

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