ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.36205975
2	regulation of DNA endoreduplication (GO:0032875)	5.15683930
3	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	5.11652190
4	pseudouridine synthesis (GO:0001522)	4.69100273
5	proteasome assembly (GO:0043248)	4.65016535
6	negative regulation of DNA-templated transcription, elongation (GO:0032785)	4.21368671
7	protein complex biogenesis (GO:0070271)	4.18410938
8	response to interferon-beta (GO:0035456)	4.10518763
9	maturation of 5.8S rRNA (GO:0000460)	4.00065874
10	protein maturation by protein folding (GO:0022417)	3.82640985
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77799480
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77799480
13	NADH dehydrogenase complex assembly (GO:0010257)	3.77799480
14	positive regulation of defense response to virus by host (GO:0002230)	3.74105136
15	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.73998058
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.69659275
17	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.69163728
18	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.63135541
19	tryptophan metabolic process (GO:0006568)	3.58787286
20	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.57167042
21	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.55596848
22	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	3.50229028
23	protein polyglutamylation (GO:0018095)	3.44245852
24	positive regulation of B cell differentiation (GO:0045579)	3.37954125
25	cellular response to interferon-beta (GO:0035458)	3.37422284
26	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.37402137
27	protein deneddylation (GO:0000338)	3.36584760
28	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.33487858
29	kynurenine metabolic process (GO:0070189)	3.29670640
30	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.26705107
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.23700897
32	indole-containing compound catabolic process (GO:0042436)	3.22591269
33	indolalkylamine catabolic process (GO:0046218)	3.22591269
34	tryptophan catabolic process (GO:0006569)	3.22591269
35	aldehyde catabolic process (GO:0046185)	3.21966049
36	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.18261024
37	regulation of cellular amino acid metabolic process (GO:0006521)	3.17162386
38	cullin deneddylation (GO:0010388)	3.15178821
39	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.14713301
40	negative regulation of ligase activity (GO:0051352)	3.14713301
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.12792282
42	cytochrome complex assembly (GO:0017004)	3.12719797
43	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.10080377
44	phenylpropanoid metabolic process (GO:0009698)	3.09383122
45	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.09151987
46	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.08533142
47	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.08533142
48	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.08533142
49	copper ion homeostasis (GO:0055070)	3.08019244
50	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.06373300
51	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.06373300
52	negative regulation of T cell differentiation in thymus (GO:0033085)	3.04160426
53	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.03589161
54	regulation of skeletal muscle contraction (GO:0014819)	3.01728703
55	establishment of viral latency (GO:0019043)	3.00840875
56	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.99637290
57	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.99637290
58	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.98218145
59	positive regulation of ligase activity (GO:0051351)	2.97038494
60	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.96602000
61	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.95661345
62	AMP metabolic process (GO:0046033)	2.94630535
63	chaperone-mediated protein transport (GO:0072321)	2.92861222
64	piRNA metabolic process (GO:0034587)	2.92570114
65	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.88089575
66	cytidine metabolic process (GO:0046087)	2.87422944
67	cytidine catabolic process (GO:0006216)	2.87422944
68	cytidine deamination (GO:0009972)	2.87422944
69	DNA catabolic process, exonucleolytic (GO:0000738)	2.83713093
70	electron transport chain (GO:0022900)	2.82974940
71	regulation of thymocyte apoptotic process (GO:0070243)	2.82574425
72	negative regulation of B cell apoptotic process (GO:0002903)	2.81859800
73	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.80465459
74	CENP-A containing nucleosome assembly (GO:0034080)	2.79857163
75	positive regulation of protein ubiquitination (GO:0031398)	2.78820471
76	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.78078635
77	respiratory electron transport chain (GO:0022904)	2.77860195
78	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.76050165
79	deoxyribonucleotide catabolic process (GO:0009264)	2.76014981
80	protein neddylation (GO:0045116)	2.75819843
81	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.75375628
82	indolalkylamine metabolic process (GO:0006586)	2.75315756
83	sister chromatid cohesion (GO:0007062)	2.75199431
84	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.74978214
85	ATP synthesis coupled proton transport (GO:0015986)	2.71412706
86	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.71412706
87	transcription from mitochondrial promoter (GO:0006390)	2.69779290
88	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.68035967
89	regulation of ligase activity (GO:0051340)	2.65905650
90	positive regulation of prostaglandin secretion (GO:0032308)	2.65375465
91	synapsis (GO:0007129)	2.65310103
92	deoxyribose phosphate catabolic process (GO:0046386)	2.63918677
93	oxidative phosphorylation (GO:0006119)	2.62887550
94	regulation of oxidative stress-induced neuron death (GO:1903203)	2.62088233
95	pyrimidine nucleotide catabolic process (GO:0006244)	2.61821083
96	regulation of germinal center formation (GO:0002634)	2.59511436
97	negative regulation of JAK-STAT cascade (GO:0046426)	2.58141604
98	positive regulation of T cell apoptotic process (GO:0070234)	2.57505523
99	cellular response to dsRNA (GO:0071359)	2.56693722
100	establishment of integrated proviral latency (GO:0075713)	2.56511181

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.48943774
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.46153578
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.13833071
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.11657458
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.84424880
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.72119711
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67123424
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.50810454
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.22501280
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.19344604
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.04157158
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.61810209
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.49177313
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.46260924
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44789853
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.35513572
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.34952213
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.30435448
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29298965
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.29006949
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.26551444
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.06938769
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.06842326
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.04524562
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.91655889
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86357721
27	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.83935312
28	EWS_26573619_Chip-Seq_HEK293_Human	1.81903056
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.67829135
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64349334
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.62022915
32	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.61537180
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.61132576
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.56923587
35	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.55527022
36	CIITA_25753668_ChIP-Seq_RAJI_Human	1.50432357
37	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.49087653
38	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.48625514
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.48029458
40	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.44732959
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.44047383
42	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.43089208
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42583344
44	MYB_26560356_Chip-Seq_TH2_Human	1.39353279
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.32494202
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31616454
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28985334
48	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.27777801
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27238619
50	GATA3_26560356_Chip-Seq_TH2_Human	1.26505817
51	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25910723
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.23711494
53	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.22622977
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20538297
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.20217074
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17916760
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.17776271
58	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.17274858
59	VDR_22108803_ChIP-Seq_LS180_Human	1.17174709
60	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.14818820
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13819862
62	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.13694638
63	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.12960114
64	GATA3_26560356_Chip-Seq_TH1_Human	1.10822217
65	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.09533255
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09255861
67	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.08792381
68	SPI1_23547873_ChIP-Seq_NB4_Human	1.06682709
69	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.06619379
70	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.06343468
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.05086085
72	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03426421
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02709671
74	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.01707441
75	FUS_26573619_Chip-Seq_HEK293_Human	1.01297976
76	AR_20517297_ChIP-Seq_VCAP_Human	1.00277029
77	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99730668
78	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.98942546
79	KDM5A_27292631_Chip-Seq_BREAST_Human	0.98635770
80	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.95623088
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95191732
82	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.94952769
83	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.94726855
84	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.94303783
85	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.93174485
86	P300_27268052_Chip-Seq_Bcells_Human	0.92566247
87	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.91514006
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.91162840
89	TP53_22573176_ChIP-Seq_HFKS_Human	0.90975785
90	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.90189010
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88866013
92	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.88097234
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.88076216
94	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.87756915
95	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87341851
96	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.86528960
97	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.86465522
98	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.86259874
99	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.86130825
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85019014

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	6.12325013
2	MP0008875_abnormal_xenobiotic_pharmacok	3.23329818
3	MP0003806_abnormal_nucleotide_metabolis	2.93763213
4	MP0003693_abnormal_embryo_hatching	2.65227174
5	MP0006072_abnormal_retinal_apoptosis	2.63089503
6	MP0010368_abnormal_lymphatic_system	2.59432024
7	MP0008058_abnormal_DNA_repair	2.57506101
8	MP0005671_abnormal_response_to	2.11631882
9	MP0008057_abnormal_DNA_replication	2.04029188
10	MP0002160_abnormal_reproductive_system	2.00892777
11	MP0001905_abnormal_dopamine_level	2.00367230
12	MP0001835_abnormal_antigen_presentation	1.93695742
13	MP0000569_abnormal_digit_pigmentation	1.91725788
14	MP0010094_abnormal_chromosome_stability	1.90423362
15	MP0006036_abnormal_mitochondrial_physio	1.88999530
16	MP0003646_muscle_fatigue	1.86143432
17	MP0001545_abnormal_hematopoietic_system	1.83347883
18	MP0005397_hematopoietic_system_phenotyp	1.83347883
19	MP0009780_abnormal_chondrocyte_physiolo	1.80498713
20	MP0003567_abnormal_fetal_cardiomyocyte	1.74033605
21	MP0005389_reproductive_system_phenotype	1.72851017
22	MP0009333_abnormal_splenocyte_physiolog	1.61384287
23	MP0000685_abnormal_immune_system	1.59258037
24	MP0001853_heart_inflammation	1.59186738
25	MP0003724_increased_susceptibility_to	1.52821824
26	MP0002166_altered_tumor_susceptibility	1.50097971
27	MP0003866_abnormal_defecation	1.49131449
28	MP0000689_abnormal_spleen_morphology	1.48936148
29	MP0000372_irregular_coat_pigmentation	1.48172776
30	MP0003718_maternal_effect	1.46439601
31	MP0002148_abnormal_hypersensitivity_rea	1.45086423
32	MP0008007_abnormal_cellular_replicative	1.42279114
33	MP0005464_abnormal_platelet_physiology	1.39740459
34	MP0004808_abnormal_hematopoietic_stem	1.37162993
35	MP0001800_abnormal_humoral_immune	1.34796464
36	MP0004957_abnormal_blastocyst_morpholog	1.34160351
37	MP0002006_tumorigenesis	1.33227014
38	MP0003045_fibrosis	1.32164191
39	MP0002722_abnormal_immune_system	1.30777546
40	MP0001790_abnormal_immune_system	1.30164188
41	MP0005387_immune_system_phenotype	1.30164188
42	MP0009046_muscle_twitch	1.29241099
43	MP0005174_abnormal_tail_pigmentation	1.28930876
44	MP0002398_abnormal_bone_marrow	1.27037798
45	MP0002420_abnormal_adaptive_immunity	1.25025133
46	MP0005000_abnormal_immune_tolerance	1.24789409
47	MP0008775_abnormal_heart_ventricle	1.24294139
48	MP0008789_abnormal_olfactory_epithelium	1.23690734
49	MP0001529_abnormal_vocalization	1.23310721
50	MP0001819_abnormal_immune_cell	1.21734096
51	MP0009697_abnormal_copulation	1.20356305
52	MP0000716_abnormal_immune_system	1.18953809
53	MP0004134_abnormal_chest_morphology	1.18622225
54	MP0003195_calcinosis	1.18234374
55	MP0005084_abnormal_gallbladder_morpholo	1.15700598
56	MP0002452_abnormal_antigen_presenting	1.15636543
57	MP0008877_abnormal_DNA_methylation	1.15020960
58	MP0002723_abnormal_immune_serum	1.12818804
59	MP0001873_stomach_inflammation	1.11538620
60	MP0000613_abnormal_salivary_gland	1.10145056
61	MP0001929_abnormal_gametogenesis	1.09518163
62	MP0005646_abnormal_pituitary_gland	1.09444520
63	MP0002210_abnormal_sex_determination	1.09068777
64	MP0001919_abnormal_reproductive_system	1.08851760
65	MP0000703_abnormal_thymus_morphology	1.08180655
66	MP0002429_abnormal_blood_cell	1.07323994
67	MP0009764_decreased_sensitivity_to	1.06981225
68	MP0001485_abnormal_pinna_reflex	1.04863953
69	MP0003252_abnormal_bile_duct	1.02249447
70	MP0000653_abnormal_sex_gland	1.02015387
71	MP0002733_abnormal_thermal_nociception	1.01439999
72	MP0003786_premature_aging	0.98534707
73	MP0003315_abnormal_perineum_morphology	0.96814594
74	MP0001145_abnormal_male_reproductive	0.96330646
75	MP0002277_abnormal_respiratory_mucosa	0.94246845
76	MP0008872_abnormal_physiological_respon	0.93402720
77	MP0005167_abnormal_blood-brain_barrier	0.92095342
78	MP0002102_abnormal_ear_morphology	0.86536940
79	MP0003077_abnormal_cell_cycle	0.83812859
80	MP0000358_abnormal_cell_content/	0.83184907
81	MP0005395_other_phenotype	0.82109234
82	MP0003763_abnormal_thymus_physiology	0.82069583
83	MP0001764_abnormal_homeostasis	0.81799774
84	MP0003186_abnormal_redox_activity	0.81639862
85	MP0005253_abnormal_eye_physiology	0.81445261
86	MP0005075_abnormal_melanosome_morpholog	0.80808386
87	MP0000383_abnormal_hair_follicle	0.79133277
88	MP0001243_abnormal_dermal_layer	0.78007742
89	MP0005636_abnormal_mineral_homeostasis	0.77372473
90	MP0005551_abnormal_eye_electrophysiolog	0.76576379
91	MP0004742_abnormal_vestibular_system	0.74492146
92	MP0003638_abnormal_response/metabolism_	0.74008309
93	MP0002837_dystrophic_cardiac_calcinosis	0.73624204
94	MP0000490_abnormal_crypts_of	0.73581444
95	MP0005025_abnormal_response_to	0.71884336
96	MP0002106_abnormal_muscle_physiology	0.71878000
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.71286682
98	MP0002282_abnormal_trachea_morphology	0.70792730
99	MP0008469_abnormal_protein_level	0.70602744
100	MP0000516_abnormal_urinary_system	0.70371958

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Conjunctival hamartoma (HP:0100780)	3.86758136
2	Type I transferrin isoform profile (HP:0003642)	3.77257359
3	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.69211794
4	Hepatocellular necrosis (HP:0001404)	3.57064233
5	Mitochondrial inheritance (HP:0001427)	3.50632010
6	Hepatic necrosis (HP:0002605)	3.46400447
7	Reticulocytopenia (HP:0001896)	3.41356065
8	Panhypogammaglobulinemia (HP:0003139)	3.38957600
9	Abnormal protein glycosylation (HP:0012346)	3.36410595
10	Abnormal glycosylation (HP:0012345)	3.36410595
11	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.36410595
12	Abnormal protein N-linked glycosylation (HP:0012347)	3.36410595
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.35350930
14	Increased CSF lactate (HP:0002490)	3.28969665
15	Molar tooth sign on MRI (HP:0002419)	3.17789025
16	Abnormality of midbrain morphology (HP:0002418)	3.17789025
17	Pancreatic cysts (HP:0001737)	3.14392543
18	Meningioma (HP:0002858)	3.13031636
19	Acute necrotizing encephalopathy (HP:0006965)	3.12335103
20	Abnormality of T cell physiology (HP:0011840)	3.09203145
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.98833001
22	Congenital stationary night blindness (HP:0007642)	2.92441324
23	Hypochromic microcytic anemia (HP:0004840)	2.89745645
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89730208
25	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.87692281
26	Fibular aplasia (HP:0002990)	2.84308923
27	Chromsome breakage (HP:0040012)	2.83942798
28	Abnormality of the renal collecting system (HP:0004742)	2.78750812
29	Abnormal number of erythroid precursors (HP:0012131)	2.75158965
30	Progressive macrocephaly (HP:0004481)	2.74028392
31	Furrowed tongue (HP:0000221)	2.71010249
32	Duplicated collecting system (HP:0000081)	2.67115641
33	Nephronophthisis (HP:0000090)	2.67063701
34	Abnormality of DNA repair (HP:0003254)	2.65457250
35	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.62577004
36	Acute encephalopathy (HP:0006846)	2.61884502
37	Congenital, generalized hypertrichosis (HP:0004540)	2.61630464
38	IgM deficiency (HP:0002850)	2.59656533
39	Clubbing of toes (HP:0100760)	2.50951309
40	Vacuolated lymphocytes (HP:0001922)	2.48726221
41	True hermaphroditism (HP:0010459)	2.46564184
42	Abnormality of cells of the erythroid lineage (HP:0012130)	2.44496305
43	Cerebral edema (HP:0002181)	2.41628835
44	Abnormality of the renal medulla (HP:0100957)	2.34654775
45	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.33485496
46	Hypoplasia of the uterus (HP:0000013)	2.33157195
47	Bile duct proliferation (HP:0001408)	2.31457437
48	Abnormal biliary tract physiology (HP:0012439)	2.31457437
49	Hypergonadotropic hypogonadism (HP:0000815)	2.29881624
50	Hamartoma of the eye (HP:0010568)	2.28282809
51	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.25846467
52	Pancreatic fibrosis (HP:0100732)	2.25286509
53	Pustule (HP:0200039)	2.24532060
54	Opisthotonus (HP:0002179)	2.24311759
55	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22740662
56	Testicular atrophy (HP:0000029)	2.22039912
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21921294
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.19002964
59	Delusions (HP:0000746)	2.16859380
60	Reduced antithrombin III activity (HP:0001976)	2.16002142
61	Gonadotropin excess (HP:0000837)	2.15815017
62	Lipid accumulation in hepatocytes (HP:0006561)	2.14174821
63	Optic disc pallor (HP:0000543)	2.10426225
64	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07800676
65	Emotional lability (HP:0000712)	2.07221386
66	Abolished electroretinogram (ERG) (HP:0000550)	2.06952724
67	Abnormality of T cells (HP:0002843)	2.06267371
68	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05195578
69	Meckel diverticulum (HP:0002245)	2.00511422
70	Attenuation of retinal blood vessels (HP:0007843)	2.00403245
71	Abnormality of B cell number (HP:0010975)	2.00318468
72	Respiratory failure (HP:0002878)	2.00139782
73	Cystic liver disease (HP:0006706)	1.98550879
74	Increased serum lactate (HP:0002151)	1.98482037
75	Dry hair (HP:0011359)	1.98193219
76	Increased hepatocellular lipid droplets (HP:0006565)	1.98112620
77	Autoimmune hemolytic anemia (HP:0001890)	1.97910523
78	Abnormality of pyrimidine metabolism (HP:0004353)	1.97112608
79	CNS demyelination (HP:0007305)	1.96411152
80	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.94967253
81	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.94841172
82	Dicarboxylic aciduria (HP:0003215)	1.94841172
83	Optic nerve coloboma (HP:0000588)	1.94777744
84	Bone cyst (HP:0012062)	1.94200985
85	Lactic acidosis (HP:0003128)	1.93619361
86	Abnormality of the ileum (HP:0001549)	1.91754689
87	Confusion (HP:0001289)	1.91111723
88	Tubulointerstitial fibrosis (HP:0005576)	1.90471691
89	Hepatosplenomegaly (HP:0001433)	1.87071115
90	Absent thumb (HP:0009777)	1.86958728
91	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.85227515
92	Paralysis (HP:0003470)	1.84082230
93	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.83597361
94	Dysautonomia (HP:0002459)	1.83405331
95	Pulmonary fibrosis (HP:0002206)	1.82326421
96	Short femoral neck (HP:0100864)	1.80516603
97	Agammaglobulinemia (HP:0004432)	1.80137974
98	Exercise intolerance (HP:0003546)	1.80014081
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.79593512
100	Short tibia (HP:0005736)	1.79374343

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.37768868
2	NME2	5.03391546
3	TESK2	3.54902730
4	BMPR1B	3.53933152
5	NUAK1	3.46620532
6	GRK1	3.39437129
7	BCKDK	3.17589900
8	CDK8	2.91204141
9	KDR	2.27280926
10	SCYL2	2.19119368
11	TIE1	2.15822554
12	TAF1	2.10412259
13	TXK	2.03930232
14	VRK1	1.99749838
15	CCNB1	1.96412840
16	BUB1	1.85147068
17	PIM2	1.78446924
18	ADRBK2	1.73539603
19	STK16	1.71823497
20	EIF2AK3	1.61349082
21	ARAF	1.57467928
22	FRK	1.56990840
23	MST4	1.49163652
24	NEK1	1.46521614
25	SRPK1	1.46250158
26	DAPK1	1.45718405
27	CSNK1G3	1.39267022
28	TESK1	1.35276919
29	CSNK1A1L	1.32803717
30	PLK2	1.26628736
31	GRK5	1.25055577
32	ZAK	1.22043605
33	TGFBR1	1.19217493
34	RAF1	1.19208042
35	MAPKAPK3	1.19164176
36	CDK19	1.13331323
37	MET	1.11081826
38	LIMK1	1.08421515
39	CSNK1G2	1.07749485
40	SMG1	1.00970934
41	PLK3	0.99011759
42	CSNK1G1	0.95339054
43	KIT	0.94841958
44	CDK9	0.94753970
45	MAPKAPK5	0.93120866
46	TLK1	0.91968545
47	PHKG1	0.89834242
48	PHKG2	0.89834242
49	SYK	0.86991069
50	PTK2B	0.86429812
51	TBK1	0.85305587
52	DYRK2	0.77949273
53	CSF1R	0.75205098
54	EIF2AK2	0.74422725
55	CDK7	0.66459735
56	ATR	0.59166870
57	PLK4	0.58508930
58	MAP4K2	0.57555622
59	EIF2AK1	0.56408316
60	ABL2	0.56197778
61	AURKA	0.47577336
62	ADRBK1	0.45821187
63	RPS6KA5	0.43839373
64	PLK1	0.43711443
65	JAK3	0.41044158
66	BMPR2	0.36387074
67	LCK	0.35019111
68	PNCK	0.34425150
69	TEC	0.33436207
70	INSRR	0.31716285
71	PINK1	0.31521681
72	IKBKB	0.30973577
73	AURKB	0.30416784
74	PRKCI	0.29367960
75	CSNK1A1	0.28153202
76	ATM	0.27537649
77	GRK6	0.27261225
78	EGFR	0.26697699
79	OBSCN	0.26508921
80	OXSR1	0.26327027
81	FGFR3	0.26224900
82	MAP3K12	0.26156729
83	MAP4K1	0.25665281
84	FLT3	0.25636210
85	CHEK2	0.24428940
86	CSNK2A1	0.23807637
87	CSNK2A2	0.23677710
88	RPS6KA4	0.23521954
89	IKBKE	0.22821592
90	PIM1	0.22409630
91	LYN	0.20302761
92	HIPK2	0.20017124
93	PAK1	0.19294119
94	IGF1R	0.19103967
95	DAPK3	0.18416342
96	MAP2K7	0.18151932
97	PRKCE	0.17550682
98	MAPK7	0.17482914
99	DYRK1A	0.16321979
100	LMTK2	0.15567708

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.95794141
2	Proteasome_Homo sapiens_hsa03050	4.38069318
3	DNA replication_Homo sapiens_hsa03030	3.20089233
4	Asthma_Homo sapiens_hsa05310	2.93806066
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77664258
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.61752932
7	Parkinsons disease_Homo sapiens_hsa05012	2.52273523
8	Base excision repair_Homo sapiens_hsa03410	2.43395902
9	Ribosome_Homo sapiens_hsa03010	2.41054136
10	Protein export_Homo sapiens_hsa03060	2.03860860
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.03788714
12	RNA degradation_Homo sapiens_hsa03018	2.02416545
13	Mismatch repair_Homo sapiens_hsa03430	2.00905333
14	Allograft rejection_Homo sapiens_hsa05330	1.85390440
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.82624629
16	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.74772696
17	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.74572870
18	RNA polymerase_Homo sapiens_hsa03020	1.72487608
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.71540336
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.68717957
21	Phototransduction_Homo sapiens_hsa04744	1.67468701
22	Spliceosome_Homo sapiens_hsa03040	1.66136024
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.65618604
24	Huntingtons disease_Homo sapiens_hsa05016	1.64237279
25	Alzheimers disease_Homo sapiens_hsa05010	1.59752948
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.48191748
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46823667
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46632422
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.44232044
30	Sulfur relay system_Homo sapiens_hsa04122	1.41900838
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.36506164
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.35719608
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29747075
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26850031
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.22840460
36	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.22466137
37	One carbon pool by folate_Homo sapiens_hsa00670	1.12834681
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.10783035
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09927266
40	Homologous recombination_Homo sapiens_hsa03440	1.06541835
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03020971
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00304726
43	Oocyte meiosis_Homo sapiens_hsa04114	0.91641148
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.89928650
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88247541
46	Viral myocarditis_Homo sapiens_hsa05416	0.88226057
47	RNA transport_Homo sapiens_hsa03013	0.87394345
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86495106
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.84823394
50	Purine metabolism_Homo sapiens_hsa00230	0.82054620
51	Folate biosynthesis_Homo sapiens_hsa00790	0.81376346
52	Herpes simplex infection_Homo sapiens_hsa05168	0.80040220
53	Basal transcription factors_Homo sapiens_hsa03022	0.79378016
54	Fatty acid elongation_Homo sapiens_hsa00062	0.79058110
55	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.79024237
56	Shigellosis_Homo sapiens_hsa05131	0.72993501
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72782627
58	Glutathione metabolism_Homo sapiens_hsa00480	0.71122566
59	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.68397086
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67772722
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65212062
62	Peroxisome_Homo sapiens_hsa04146	0.63739122
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63577545
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63070747
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61220160
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57126809
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55733000
68	Cell cycle_Homo sapiens_hsa04110	0.55581030
69	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.53069103
70	Olfactory transduction_Homo sapiens_hsa04740	0.52671339
71	Metabolic pathways_Homo sapiens_hsa01100	0.51905957
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48135029
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45504628
74	Salivary secretion_Homo sapiens_hsa04970	0.45305124
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44696656
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42816307
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42775883
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40679866
79	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40178725
80	Retinol metabolism_Homo sapiens_hsa00830	0.40065389
81	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.39844268
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.37617018
83	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.37487345
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32628570
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.31728827
86	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.30988107
87	Linoleic acid metabolism_Homo sapiens_hsa00591	0.29646175
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29588024
89	Propanoate metabolism_Homo sapiens_hsa00640	0.28218771
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.25835314
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.25349558
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.25056516
93	Leishmaniasis_Homo sapiens_hsa05140	0.23832319
94	Tuberculosis_Homo sapiens_hsa05152	0.23688901
95	Other glycan degradation_Homo sapiens_hsa00511	0.23368389
96	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.23156623
97	Regulation of autophagy_Homo sapiens_hsa04140	0.22587940
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.20652645
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.18448634
100	Pentose phosphate pathway_Homo sapiens_hsa00030	0.17147647

HMGN2P40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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